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https://www.readbyqxmd.com/read/29053591/real-time-monitoring-of-water-content-in-sandy-soil-using-shear-mode-piezoceramic-transducers-and-active-sensing-a-feasibility-study
#1
Qingzhao Kong, Hongli Chen, Yi-Lung Mo, Gangbing Song
A quantitative understanding of soil water content or soil water status is of great importance to many applications, such as landslide monitoring, rockfill dam health monitoring, precision agriculture, etc. In this paper, a feasibility study was conducted to monitor the soil water content in real time using permanent embedded piezoceramic-based transducers called smart aggregates (SAs). An active sensing approach using a customized swept acoustic wave with a frequency range between 100 Hz and 300 kHz was used to study the wave attenuation in the soil in correlation to soil moisture levels...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29044946/aquaporin-1-inhibition-reduces-metastatic-formation-in-a-mouse-model-of-melanoma
#2
Laura Simone, Concetta Domenica Gargano, Francesco Pisani, Antonio Cibelli, Maria Grazia Mola, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Aquaporin-1 (AQP1) is a proangiogenic water channel protein promoting endothelial cell migration. We previously reported that AQP1 silencing by RNA interference reduces angiogenesis-dependent primary tumour growth in a mouse model of melanoma. In this study, we tested the hypothesis that AQP1 inhibition also affects animal survival and lung nodule formation. Melanoma was induced by injecting B16F10 cells into the back of C57BL6J mice. Intratumoural injection of AQP1 siRNA and CTRL siRNA was performed 10 days after tumour cell implantation...
October 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29040264/comparison-of-pulmonary-vascular-permeability-index-pvpi-and-global-ejection-fraction-gef-derived-from-jugular-and-femoral-indicator-injection-using-the-picco-2-device-a-prospective-observational-study
#3
Wolfgang Huber, Andrea Gruber, Maximilian Eckmann, Felicia Elkmann, Ines Klein, Tobias Lahmer, Ulrich Mayr, Raphael Schellnegger, Jochen Schneider, Gonzalo Batres-Baires, Lisa Fekecs, Analena Beitz, Helena Berbara, Roland Schmid, Alexander Herner
BACKGROUND: Transpulmonary thermodilution (TPTD) is used to derive cardiac output CO, global end-diastolic volume GEDV and extravascular lung water EVLW. To facilitate interpretation of these data, several ratios have been developed, including pulmonary vascular permeability index (defined as EVLW/(0.25*GEDV)) and global ejection fraction ((4*stroke volume)/GEDV). PVPI and GEF have been associated to the aetiology of pulmonary oedema and systolic cardiac function, respectively. Several studies demonstrated that the use of femoral venous access results in a marked overestimation of GEDV...
2017: PloS One
https://www.readbyqxmd.com/read/29039541/modulation-of-mitogen%C3%A2-activated-protein-kinase-attenuates-sepsis%C3%A2-induced-acute-lung-injury-in-acute-respiratory-distress-syndrome-rats
#4
Wei Fang, Shi-Xia Cai, Chuan-Lei Wang, Xiao-Xia Sun, Kun Li, Xiao-Wen Yan, Yun-Bo Sun, Xiao-Zhe Sun, Chuan-Kai Gu, Ming-Ying Dai, Hui-Ming Wang, Zhen Zhou
Sepsis is the most important predisposing cause inducing acute respiratory distress syndrome (ARDS); however, the mechanism of sepsis leading to the development of ARDS remains to be elucidated. Suppression of the mitogen‑activated protein kinase (MAPK) signal by blocking the phosphorylation of Jun N‑terminal kinase (JNK) and p38 in lung tissues could alleviate acute lung injury induced by sepsis. MAPK signaling may have a crucial role in development of the sepsis‑induced acute lung injury. The specific inhibitors of JNK and p38 MAPK, SP600125 and SB203580, were administrated by intragastric injection 4 h before induction of ARDS after cecal ligation and puncture (CLP)...
October 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037999/protective-effect-of-silk-fibroin-in-burn-injury-in-rat-model
#5
Asli Aykac, Buse Karanlık, Ahmet Ozer Sehirli
Activation of pro-inflamatuar pathways play major role in formation of major complications as a result of burns. This study was planned to investigate the protective effect of Silk Fibroin in lung injury caused by burn in the experimental rat model. After rinsing the skin of rats under ether anesthesia, the exposed back region, covers 30% of the total body, was kept in the 90°C water bath for 10s. The control rats were kept in the 25°C water bath for 10s. Immediately after burning process, silk fibroin was administered orally at a dose of 600mg/kg...
October 13, 2017: Gene
https://www.readbyqxmd.com/read/29033472/histopathological-analysis-of-the-f344-rat-lung-upon-exposure-to-retenoic-acid-ovalbumin-mold-spores-and-citral
#6
Ibrahim O Farah, Carlene Holt-Gray, Joseph A Cameron, Michelle Tucci, Hamed Benghuzzi
The paradoxical role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of allergic and/or inflammatory complications in contrast to a therapeutic modality for lung pathology is not well understood or established in the literature. As well, the role of Citral (inhibitor of retinoid function; a non-toxic chemical that exists in two forms (diethyl; C1 or cis-trans dimethyl; C2), in the reversal of retinoic acid, ovalbumin and allergic mold spore pathophysiology is also not well ascertained under an in vivo setting...
March 2017: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/29032447/evaluation-and-calibration-of-high-throughput-predictions-of-chemical-distribution-to-tissues
#7
Robert G Pearce, R Woodrow Setzer, Jimena L Davis, John F Wambaugh
Toxicokinetics (TK) provides critical information for integrating chemical toxicity and exposure assessments in order to determine potential chemical risk (i.e., the margin between toxic doses and plausible exposures). For thousands of chemicals that are present in our environment, in vivo TK data are lacking. The publicly available R package "httk" (version 1.8, named for "high throughput TK") draws from a database of in vitro data and physico-chemical properties in order to run physiologically-based TK (PBTK) models for 553 compounds...
October 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29032042/a-reliable-and-stable-method-for-determination-of-brigatinib-in-rat-plasma-by-uplc-ms-ms-application-to-a-pharmacokinetic-study
#8
Jian Wen, Susu Bao, Yaoyao Cai, Bowen Zhang, Rongrong Wang, Chenchen Wang, Guoxin Hu
Brigatinib is the second-generation anaplastic lymphoma kinase - inhibitor in non-small cell lung cancer and it can overcome the crizotinib-resistance. Chromatographic separation was carried out on an Acquity Ultra Performance Liquid Chromatography (UPLC) unit with a BEH C18 column (2.1mm×50mm, 1.7μm). The mobile phase was composed of acetonitrile and 0.1% formic acid in water. No endogenous interfering compounds was discovered at retention time of brigatinib (0.56min) and imatinib (IS, 1.41min). MS/MS detection was performed in positive mode...
October 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#9
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29028683/lung-cancer-associated-with-arsenic-ingestion-cell-type-specificity-and-dose-response
#10
Yau-Chang Kuo, Yu-Shing Lo, How-Ran Guo
BACKGROUND: Arsenic is a well-documented human carcinogen, and studies on urinary and skin cancers have shown that the carcinogenicity of ingested arsenic has cell-type specificity. To evaluate whether this is also true for lung cancers, we conducted a study on 243 townships in Taiwan. METHODS: The arsenic levels were assessed using measurement reports from a previous survey, and the incidence of lung cancer was assessed using the data gathered by the National Cancer Registry Program...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29026006/potential-contribution-of-alveolar-epithelial-type-i-cells-to-pulmonary-fibrosis
#11
Michael Kasper, Kathrin Barth
Pulmonary fibrosis is characterized by inflammation and fibrosis of the interstitium and destruction of alveolar histoarchitecture ultimately leading to a fatal impairment of lung function. Different concepts describe either a dominant role of inflammatory pathways or a disturbed remodeling of resident cells of the lung parenchyma during fibrogenesis. Further, a combination of both mechanisms has been postulated. The present review emphasizes the particular involvement of alveolar epithelial type I cells in all of these processes, their contribution to innate immune/inflammatory functions and maintenance of proper alveolar barrier functions...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29025712/ion-channels-of-the-lung-and-their-role-in-disease-pathogenesis
#12
Rafal Bartoszewski, Sadis Matalon, James F Collawn
Maintenance of normal epithelial ion and water transport in the lungs includes providing a thin layer of surface liquid that coats the conducting airways. This airway surface liquid is critical for normal lung function in a number of ways, but perhaps most importantly, is required for normal mucociliary clearance and bacterial removal. Preservation of the appropriate level of hydration, pH and viscosity for the airway surface liquid requires the proper regulation and function of a battery of different types of ion channels and transporters...
October 12, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#13
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29020656/dna-binding-and-in-vitro-anticarcinogenic-activity-of-a-series-of-newfashioned-cu-ii-complexes-based-on-tricationic-metalloporphyrin-salicyloylhydrazone-ligands
#14
Xiaoxia Feng, Jiacheng Liu
Four novel water-soluble Cu(II) derivatives based on the meso-10, 15, 20-Tris (N-methyl-X-pyridyl)-5-(4'-salicyloylhydrazone) metalloporphyrin ligands (X=4, M=Zn(1) Co(2); X=2, M=Zn(3), Co(4)), have been prepared and isolated. Various physicochemical techniques indicate that complex 2 interacts with calf thymus DNA stronger than the others through partial intercalation, suggesting that Co(II) has no axial ligands at porphyrin core plays a crucial role, interestingly, 2 exhibits higher DNA binding affinity compared to 4, which could be ascribed to the influences of peripheral electronic effect of porphyrin ring...
September 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29018617/perch-perca-fluviatilis-show-a-directional-preference-for-but-do-not-increase-attacks-toward-prey-in-response-to-water-borne-cortisol
#15
Lindsay J Henderson, Mary R Ryan, Hannah M Rowland
In freshwater environments, chemosensory cues play an important role in predator-prey interactions. Prey use a variety of chemosensory cues to detect and avoid predators. However, whether predators use the chemical cues released by disturbed or stressed prey has received less attention. Here we tested the hypothesis that the disturbance cue cortisol, in conjunction with visual cues of prey, elevates predatory behavior. We presented predators (perch, Perca fluviatilis) with three chemosensory choice tests and recorded their location, orientation, and aggressive behavior...
2017: PeerJ
https://www.readbyqxmd.com/read/28989102/comparative-evaluation-of-electrospraying-and-lyophilization-techniques-on-solid-state-properties-of-erlotinib-nanocrystals-assessment-of-in-vitro-cytotoxicity
#16
Shreya Thakkar, Dilip Sharma, Manju Misra
INTRODUCTION: Erlotinib is a well known FDA approved drug from category of tyrosine kinase inhibitors; used for the treatment of lung cancer. However its use is limited because of its poor water solubility. OBJECTIVE: The aim of present work was to improve solubility by developing a stable nanocrystal based drug delivery system of ERL with the aid of sodium lauryl sulfate as potential stabilizer and to carry out comparative evaluation of electrospraying and lyophilization as solidification techniques on its solid state properties...
October 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28986987/monte-carlo-simulations-of-a-kilovoltage-external-beam-radiotherapy-system-on-phantoms-and-breast-patients
#17
Dylan Y Breitkreutz, Michael D Weil, Sergei Zavgorodni, Magdalena Bazalova-Carter
PURPOSE: To determine the most suitable lesion size and depth for radiotherapy treatments with a prototype kilovoltage x-ray arc therapy (KVAT) system through Monte Carlo simulations of the dose delivered to lesion, dose homogeneity and lesion-to-skin ratio. METHODS: Monte Carlo simulations were used to calculate dose distributions generated by a novel low-energy kilovoltage x-ray system to a variety of clinically relevant lesion sizes and depths in phantoms and for hypothetical partial breast irradiations of patients in supine and prone positions...
October 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28986814/effect-of-shen-fu-injection-on-hemodynamics-in-early-volume-resuscitation-treated-septic-shock-patients
#18
Kai-Liang Fan, Jun-Hui Wang, Li Kong, Fei-Hu Zhang, Hao Hao, Hao Zhao, Zheng-Yun Tian, Ming-Xin Yin, Hua Fang, Hui-Hui Yang, Yang Liu
OBJECTIVE: To investigate the hemodynamic effect of Shen-Fu Injection (, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output (PICCO). METHODS: All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1st, 2014 to December 31th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group (33 cases) and control group (32 cases)...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28985133/organ-doses-associated-with-partial-body-irradiation-with-2-5-bone-marrow-sparing-of-the-non-human-primate-a-retrospective-study
#19
C Prado, T J MacVittie, A W Bennett, A Kazi, A M Farese, K Prado
A partial-body irradiation model with approximately 2.5% bone marrow sparing (PBI/BM2.5) was established to determine the radiation dose-response relationships for the prolonged and delayed multi-organ effects of acute radiation exposure. Historically, doses reported to the entire body were assumed to be equal to the prescribed dose at some defined calculation point, and the dose-response relationship for multi-organ injury has been defined relative to the prescribed dose being delivered at this point, e.g...
October 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28984820/histopathology-of-cervical-cancer-and-arsenic-concentration-in-well-water-an-ecological-analysis
#20
Mohammad Golam Mostafa, Zarat Jahin Queen, Nicola Cherry
Arsenic in drinking water is causally linked with cancer of the skin, lung, and urinary bladder, but there is very little data on a possible role for arsenic in the etiology of cervical cancer, a disease in which human papilloma virus is held to be a necessary but not sufficient cause. All histopathology results from cervical specimens from the National Institute of Cancer Research and Hospital (NICRH), Dhaka (1997-2015), and the Anowara Medical Services (2003-2015), both serving the whole of Bangladesh, were classified by cell type...
October 6, 2017: International Journal of Environmental Research and Public Health
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