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https://www.readbyqxmd.com/read/29679805/poly-l-lysine-modified-cryogels-for-efficient-bilirubin-removal-from-human-plasma
#1
Mehmet Emin Çorman
In this study, poly-l-lysine (PLL) immobilized PHEMA cryogel was designed for the specific bilirubin removal from human plasma. The surface of PHEMA cryogels is surrounded by PLL chains to enhance specific binding of bilirubin molecules via specific complementary electrostatic interactions. The functionalization of the PHEMA cryogel was carried out by direct coupling of PLL to pre-activated OH-group of the HEMA alcohol units via carbodiimide activation. Prior to removal of bilirubin from human plasma, the optimization parameters including, initial bilirubin concentration, flow rate, temperature, ionic strength, and adsorption rates on adsorption of PLL-PHEMA cryogel were investigated from the aqueous medium...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29679321/low-temperature-deposition-modeling-of-%C3%AE-tcp-scaffolds-with-controlled-bimodal-porosity
#2
E Papastavrou, P Breedon, D Fairhurst
Low-temperature deposition modeling (LDM), otherwise termed freeze-form extrusion fabrication or rapid freeze prototyping, involves dispensing an aqueous-based ceramic paste or polymeric hydrogel along predefined paths in subzero ambient temperatures, followed by freeze-drying. The solidification of the material after the deposition of each layer enables large parts to be built without the need for organic binders, which can often have cytotoxic effects. Freeze-dried parts obtained from LDM typically exhibit pores with openings that range in average between 1 and 40 μm...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29678495/self-activation-of-biochar-from-furfural-residues-by-recycled-pyrolysis-gas
#3
Yulei Yin, Yuan Gao, Aimin Li
Biochar samples with controllable specific surface area and mesopore ratio were self-activated from furfural residues by recycled pyrolysis gas. The objective of this study was to develop a new cyclic utilization method for the gas produced by pyrolysis. The influences of preparation parameters on the resulting biochar were studied by varying the pyrolysis-gas flow rate, activation time and temperature. Structural characterization of the produced biochar was performed by analysis of nitrogen adsorption isotherms at 77 K and scanning electron microscope (SEM)...
April 17, 2018: Waste Management
https://www.readbyqxmd.com/read/29677679/a-four-parameter-optimization-and-troubleshooting-of-a-rplc-charged-aerosol-detection-stability-indicating-method-for-determination-of-s-lysophosphatidylcholines-in-a-phospholipid-formulation
#4
James Tam, Imad A Haidar Ahmad, Andrei Blasko
A four parameter optimization of a stability indicating method for non-chromophoric degradation products of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1-stearoyl-sn-glycero-3-phosphocholine and 2-stearoyl-sn-glycero-3-phosphocholine was achieved using a reverse phase liquid chromatography-charged aerosol detection (RPLC-CAD) technique. Using the hydrophobic subtraction model of selectivity, a core-shell, polar embedded RPLC column was selected followed by gradient-temperature optimization, resulting in ideal relative peak placements for a robust, stability indicating separation...
April 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29677567/methods-for-assessing-mitochondrial-quality-control-mechanisms-and-cellular-consequences-in-cell-culture
#5
Matthew Redmann, Gloria A Benavides, Willayat Yousuf Wani, Taylor F Berryhill, Xiaosen Ouyang, Michelle S Johnson, Saranya Ravi, Kasturi Mitra, Stephen Barnes, Victor M Darley-Usmar, Jianhua Zhang
Mitochondrial quality is under surveillance by autophagy, the cell recycling process which degrades and removes damaged mitochondria. Inadequate autophagy results in deterioration in mitochondrial quality, bioenergetic dysfunction, and metabolic stress. Here we describe in an integrated work-flow to assess parameters of mitochondrial morphology, function, mtDNA and protein damage, metabolism and autophagy regulation to provide the framework for a practical assessment of mitochondrial quality. This protocol has been tested with cell cultures, is highly reproducible, and is adaptable to studies when cell numbers are limited, and thus will be of interest to researchers studying diverse physiological and pathological phenomena in which decreased mitochondrial quality is a contributory factor...
April 10, 2018: Redox Biology
https://www.readbyqxmd.com/read/29677356/volume-rendered-projection-resolved-oct-angiography-3d-lesion-complexity-is-associated-with-therapy-response-in-wet-age-related-macular-degeneration
#6
Peter L Nesper, Brian T Soetikno, Alison D Treister, Amani A Fawzi
Purpose: To explore whether quantitative three-dimensional (3D) analysis of choroidal neovascularization (CNV) using projection-resolved optical coherence tomography angiography (PR-OCTA) is associated with treatment response in neovascular age-related macular degeneration (nAMD). Methods: Retrospective, cross-sectional study of 51 eyes of 49 patients undergoing individualized anti-VEGF therapy for nAMD. Patients were classified as "good" or "poor" responders, requiring injections at less or more frequently than 6-week intervals, respectively...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677351/retinal-oxygen-delivery-and-metabolism-in-healthy-and-sickle-cell-retinopathy-subjects
#7
Mahnaz Shahidi, Anthony E Felder, Ou Tan, Norman P Blair, David Huang
Purpose: Reduction in inner retinal oxygen delivery (DO2) can cause retinal hypoxia and impair inner retinal oxygen metabolism (MO2), leading to vision loss. The purpose of the current study was to establish measurements of DO2 and MO2 in healthy subjects and test the hypothesis that DO2 and MO2 are reduced in sickle cell retinopathy (SCR) subjects. Methods: Dual wavelength retinal oximetry and Doppler optical coherence tomography were performed in 12 healthy control and 12 SCR subjects...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677212/pulsatile-operation-of-a-continuous-flow-right-ventricular-assist-device-rvad-to-improve-vascular-pulsatility
#8
Boon C Ng, Matthias Kleinheyer, Peter A Smith, Daniel Timms, William E Cohn, Einly Lim
Despite the widespread acceptance of rotary blood pump (RBP) in clinical use over the past decades, the diminished flow pulsatility generated by a fixed speed RBP has been regarded as a potential factor that may lead to adverse events such as vasculature stiffening and hemorrhagic strokes. In this study, we investigate the feasibility of generating physiological pulse pressure in the pulmonary circulation by modulating the speed of a right ventricular assist device (RVAD) in a mock circulation loop. A rectangular pulse profile with predetermined pulse width has been implemented as the pump speed pattern with two different phase shifts (0% and 50%) with respect to the ventricular contraction...
2018: PloS One
https://www.readbyqxmd.com/read/29677152/optimization-of-the-critical-parameters-of-the-spherical-agglomeration-crystallization-method-by-the-application-of-the-quality-by-design-approach
#9
Orsolya Gyulai, Anita Kovács, Tamás Sovány, Ildikó Csóka, Zoltán Aigner
This research work presents the use of the Quality by Design (QbD) concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl). AMB HCl spherical crystals were formulated by the spherical agglomeration method, which was applied as an antisolvent technique. Spherical crystals have good flowing properties, which makes the direct compression tableting method applicable. This means that the amount of additives used can be reduced and smaller tablets can be formed...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29676693/intraoperative-evaluation-of-local-cerebral-hemodynamic-change-by-indocyanine-green-videoangiography-prediction-of-incidence-and-duration-of-postoperative-transient-neurological-events-in-patients-with-moyamoya-disease
#10
Kenji Uda, Yoshio Araki, Shinsuke Muraoka, Shinji Ota, Kentaro Wada, Kinya Yokoyama, Masahiro Nishihori, Takashi Izumi, Sho Okamoto, Toshihiko Wakabayashi
OBJECTIVE Transient neurological events (TNEs) occur frequently in the acute phase after direct bypass surgery for moyamoya disease (MMD), but there is currently no way to predict them. FlowInsight is a specialized software for analyzing indocyanine green (ICG) videoangiography taken with a surgical microscope. The purpose of this study was to investigate whether intraoperative evaluation of local hemodynamic changes around anastomotic sites using FlowInsight could predict the incidence and duration of TNEs...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676661/atomistic-mechanisms-of-the-double-proton-transfer-in-the-h-bonded-nucleobase-pairs-qm-qtaim-computational-lessons
#11
Ol'ha O Brovarets', Dmytro M Hovorun
In this Review we have summarized and generalized the results of the investigation of the microstructural mechanisms of the tautomerisation by the counter movement of the protons along the neighboring intermolecular H-bonds in 22 biologically important pairs of nucleotide bases in the framework of the original method, which allows to trace the evolution of the physico-chemical parameters, that characterize these processes along the intrinsic reaction coordinate (IRC). It was demonstrated the performance of the introduction of the conception of the key points (KPs) (from nine to five, depending on the symmetry and nature of system), which exhaustively characterize the flow of the tautomerisation processes...
April 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29676482/severe-heart-failure-nyha-class-iv-is-associated-with-increased-left-ventricular-mass-index-and-short-mitral-deceleration-time-in-severe-aortic-valve-stenosis
#12
Sayuki Kobayashi, Hiroto Utsunomiya, Takahiro Shiota
BACKGROUND: In aortic valve stenosis (AS), congestive heart failure (CHF) is a well-established symptom that indicates the need for surgical aortic valve replacement (SAVR). However, it is difficult to judge whether CHF symptoms such as dyspnea are caused by severe AS or other conditions, especially in elderly persons with restricted mobility or other organ complications. It is important to identify objective and noninvasive parameters associated with severe CHF symptoms in severe AS...
April 20, 2018: Echocardiography
https://www.readbyqxmd.com/read/29676290/increased-expression-of-pelp1-in-human-sperm-is-correlated-with-decreased-semen-quality
#13
Izabela Skibinska, Miroslaw Andrusiewicz, Michal Soin, Magdalena Jendraszak, Paulina Urbaniak, Piotr Jedrzejczak, Malgorzata Kotwicka
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters...
April 20, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29675404/neonatal-hemodynamics-from-developmental-physiology-to-comprehensive-monitoring
#14
REVIEW
Sabine L Vrancken, Arno F van Heijst, Willem P de Boode
Maintenance of neonatal circulatory homeostasis is a real challenge, due to the complex physiology during postnatal transition and the inherent immaturity of the cardiovascular system and other relevant organs. It is known that abnormal cardiovascular function during the neonatal period is associated with increased risk of severe morbidity and mortality. Understanding the functional and structural characteristics of the neonatal circulation is, therefore, essential, as therapeutic hemodynamic interventions should be based on the assumed underlying (patho)physiology...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29675287/towards-a-dual-lateral-flow-nanobiosensor-for-simultaneous-detection-of-virus-genotype-specific-pcr-products
#15
Dimitra K Toubanaki, Evdokia Karagouni
Nervous necrosis virus (nodavirus) has been responsible for mass mortalities in aquaculture industry worldwide, with great economic and environmental impact. A rapid low-cost test to identify nodavirus genotype could have important benefits for vaccine and diagnostic applications in small- and medium-scale laboratories in both academia and fish farming industry. A dual lateral flow biosensor for simultaneous detection of the most prevalent nodavirus genotypes (RGNNV and SJNNV) was developed and optimized. The dual biosensor consisted of two antibody-based test zones, indicative of each genotype, and a control zone...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29675268/stochastic-system-identification-without-an-a-priori-chosen-kinetic-model-exploring-feasible-cell-regulation-with-piecewise-linear-functions
#16
Martin Hoffmann, Jörg Galle
Kinetic models are at the heart of system identification. A priori chosen rate functions may, however, be unfitting or too restrictive for complex or previously unanticipated regulation. We applied general purpose piecewise linear functions for stochastic system identification in one dimension using published flow cytometry data on E.coli and report on identification results for equilibrium state and dynamic time series. In metabolic labelling experiments during yeast osmotic stress response, we find mRNA production and degradation to be strongly co-regulated...
2018: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/29674973/hepatic-hemangiomas-alter-morphometry-and-impair-hemodynamics-of-the-abdominal-aorta-and-primary-branches-from-computer-simulations
#17
Xiaoping Yin, Xu Huang, Qiao Li, Li Li, Pei Niu, Minglu Cao, Fei Guo, Xuechao Li, Wenchang Tan, Yunlong Huo
Background: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls. Methods: Based on morphometry reconstructed from CT images, geometrical models were meshed with prismatic elements for the near wall region and tetrahedral and hexahedral elements for the core region...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#18
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29674160/optimization-and-assessment-of-fe-electrocoagulation-for-the-removal-of-potentially-toxic-metals-from-real-smelting-wastewater
#19
Longqian Xu, Xiaojun Xu, Guangzhu Cao, Shuli Liu, Zhengyang Duan, Shumin Song, Mingyao Song, Mengjiao Zhang
This study evaluates the performance of a continuous electrocoagulation system (batch recirculation mode) on the simultaneous removal of Zn2+ , Cd2+ , and Mn2+ from real smelting wastewater by using Fe-Fe electrodes. Several parameters are evaluated to determine the optimal operating conditions. These conditions include the type of power supply (p), current density (j), aeration intensity (v), flow rate (u), and anions (SO4 2- and SO3 2- ). At current density = 10-20 mA/cm2 , the DC power supply performs better than the APC power supply in treating wastewater...
April 16, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29674122/4-fluorobenzaldehyde-limonene-based-thiosemicarbazone-induces-apoptosis-in-pc-3-human-prostate-cancer-cells
#20
Bruna Dos Santos Rodrigues, Renato Ivan de Ávila, Polyana Lopes Benfica, Ludmila Pires Bringel, Cecília Maria Alves de Oliveira, Fábio Vandresen, Cleuza Conceição da Silva, Marize Campos Valadares
AIMS: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. MAIN METHODS: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry...
April 16, 2018: Life Sciences
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