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https://www.readbyqxmd.com/read/27933513/effect-of-yiqi-tongyang-decoction-on-blood-t-cell-subsets-in-patients-with-chronic-immune-thrombocytopenia
#1
Xiu-Peng Yang, Rou Ma, Xiao-Hong Yang, Hui-Lan Zhu, Yong-Gang Xu
OBJECTIVE: To measure the proportions of blood T cell subsets, Th1, Th2, Th17, Th22, and Treg cells, and other parameters in patients with chronic immune thrombocytopenia (CITP) before and after treatment with Yiqi Tongyang Decoction (, YTD) to explore T cell status of patients with CITP, and to define the mechanism of action of YTD. METHODS: The changes in peripheral blood T lymphocyte subsets, and those of Th1, Th2, Th17, Th22, and Treg cells in 30 patients with CITP (22 females and 8 males) were analyzed using multiparametric flow cytometry before and after treatment with YTD for 6 months, and 26 healthy volunteers (14 males and 12 females) acted as a control...
December 9, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27932874/bronchodilator-response-of-advanced-lung-function-parameters-depending-on-copd-severity
#2
Linnea Jarenbäck, Göran Eriksson, Stefan Peterson, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson
BACKGROUND: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. PURPOSE: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. PATIENTS AND METHODS: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27932503/computational-modelling-of-epithelial-fluid-and-ion-transport-in-the-parotid-duct-after-transfection-of-human-aquaporin-1
#3
Shelley Fong, John A Chiorini, James Sneyd, Vinod Suresh
Previous studies have shown that localized delivery of the aquaporin-1 (AQP1) gene to the parotid duct can restore saliva flow in minipigs following irradiation-induced salivary hypofunction. The resulting flow rate and electrochemisty of secreted saliva contradicts current understanding of ductal fluid transport. We hypothesized that changes in expression of ion transport proteins have occurred following AQP1 transfection. We use a mathematical model of ion and fluid transport across the parotid duct epithelial cells to predict the expression profile of ion transporters that are consistent with the experimental measurements of saliva composition and secretion rates...
December 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27932251/a-meta-analysis-of-arterial-spin-labelling-perfusion-values-for-the-prediction-of-glioma-grade
#4
L Kong, H Chen, Y Yang, L Chen
AIM: To investigate the ability of arterial spin labelling (ASL) perfusion parameters to distinguish high-grade from low-grade gliomas. MATERIALS AND METHODS: The PubMed and EMBASE databases were systematically searched for relevant articles published up to September 2015. Studies that evaluated both high- and low-grade gliomas using ASL were included. The random effect model was used to calculate the standardised mean difference (SMD) of maximum mean absolute tumour blood flow values (aTBFmax, aTBFmean) and maximum mean relative tumour blood flow (rTBFmax, rTBFmean) between high- and low-grade gliomas...
December 5, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27931937/influence-of-capillary-barrier-effect-on-biogas-distribution-at-the-base-of-passive-methane-oxidation-biosystems-parametric-study
#5
Bahar Ahoughalandari, Alexandre R Cabral
The efficiency of methane oxidation in passive methane oxidation biosystems (PMOBs) is influenced by, among other things, the intensity and distribution of the CH4 loading at the base of the methane oxidation layer (MOL). Both the intensity and distribution are affected by the capillary barrier that results from the superposition of the two materials constituting the PMOB, namely the MOL and the gas distribution layer (GDL). The effect of capillary barriers on the unsaturated flow of water has been well documented in the literature...
December 5, 2016: Waste Management
https://www.readbyqxmd.com/read/27931807/measuring-reproducibility-of-dose-response-data-for-the-pig-a-assay-using-covariate-benchmark-dose-analysis
#6
George E Johnson, Mika Yamamoto, Yuta Suzuki, Hideki Adachi, Takahiro Kyoya, Hironao Takasawa, Katsuyoshi Horibata, Eri Tsutsumi, Kunio Wada, Ryuta Kikuzuki, Ikuma Yoshida, Takafumi Kimoto, Akihisa Maeda, Kazunori Narumi
The reproducibility of the in vivo Pig-a gene mutation test system was assessed across 13 different Japanese laboratories. In each laboratory rats were exposed to the same dosing regimen of N-nitroso-N-ethylurea (ENU), and red blood cells (RBCs) and reticulocytes (RETs) were collected for mutant phenotypic analysis using flow cytometry. Mutant frequency dose response data were analysed using the PROAST benchmark dose (BMD) statistical package. Laboratory was used as a covariate during the analysis to allow all dose responses to be analysed at the same time, with conserved shape parameters...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931565/ex%C3%A2-vivo-perfusion-characteristics-of-donation-after-cardiac-death-kidneys-predict-long-term-graft-survival
#7
M Sevinc, S Stamp, J Ling, N Carter, D Talbot, N Sheerin
BACKGROUND: Ex vivo perfusion is used in our unit for kidneys donated after cardiac death (DCD). Perfusion flow index (PFI), resistance, and perfusate glutathione S-transferase (GST) can be measured to assess graft viability. We assessed whether measurements taken during perfusion could predict long-term outcome after transplantation. METHODS: All DCD kidney transplants performed from 2002 to 2014 were included in this study. The exclusion criteria were: incomplete data, kidneys not machine perfused, kidneys perfused in continuous mode, and dual transplantation...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930555/establishment-of-the-intracranial-hemodynamic-model-based-on-contrast-medium-and-clinical-applications
#8
Yaoer Cheng, Wen He
Ischemic cerebrovascular diseases are one of the most common vascular diseases in aged people and CT perfusion (CTP) is a very popular tool to detect the ischemic changes in brain vascular. The present study aims to establish a novel intracranial hemodynamic model to simulate anterior cerebral artery blood flow, and compare the actual and simulated hemodynamic parameters of healthy people and patients with carotid stenosis or occlusion.A mathematical model of the intracranial hemodynamic was generated using MATLAB software, and data from patients with or without infarct disease (57 and 44 cases, respectively) were retrospectively collected to test the new model...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929662/insulinoma-detection-with-mdct-is-there-a-role-for-whole-pancreas-perfusion
#9
Liang Zhu, Huadan Xue, Hao Sun, Xuan Wang, Wenming Wu, Zhengyu Jin, Yupei Zhao
OBJECTIVE: The purpose of this study is to investigate the role of whole-pancreas perfusion in detecting insulinomas with the use of MDCT. MATERIALS AND METHODS: From January 2011 to December 2011, a total of 70 consecutive patients (33 men and 37 women; mean age, 46 years; range, 17-73 years) who underwent biphasic contrast-enhanced CT and whole-pancreas CT perfusion for suspected insulinomas were identified retrospectively. Patients were monitored for at least 3 years...
December 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27929172/kinetics-of-the-reversible-inclusion-of-flavopereirine-in-cucurbit-7-uril
#10
Zsombor Miskolczy, László Biczók, István Jablonkai
The temperature dependence of the kinetics of flavopereirine inclusion in cucurbit[7]uril (CB7) was studied by a stopped-flow method in water. The substantial blue-shift of the emission band and the ∼4-fold fluorescence quantum yield enhancement upon host-guest binding permitted the monitoring of the formation and dissociation of the flavopereirine-CB7 1 : 1 complex in real time. The competitive binding of the 1-adamantylammonium cation with extremely high affinity was exploited to selectively and very accurately determine the kinetic parameters of the exit of flavopereirine from the CB7 cavity...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27928970/effect-of-transfection-and-co-incubation-of-bovine-sperm-with-exogenous-dna-on-sperm-quality-and-functional-parameters-for-its-use-in-sperm-mediated-gene-transfer
#11
María Elena Arias, Esther Sánchez-Villalba, Andrea Delgado, Ricardo Felmer
Sperm-mediated gene transfer (SMGT) is based on the capacity of sperm to bind exogenous DNA and transfer it into the oocyte during fertilization. In bovines, the progress of this technology has been slow due to the poor reproducibility and efficiency of the production of transgenic embryos. The aim of the present study was to evaluate the effects of different sperm transfection systems on the quality and functional parameters of sperm. Additionally, the ability of sperm to bind and incorporate exogenous DNA was assessed...
December 8, 2016: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/27925647/left-ventricular-function-assessed-by-one-point-carotid-wave-intensity-in-newly-diagnosed-untreated-hypertensive-patients
#12
Olga Vriz, Serena Favretto, Joanna Jaroch, Rychard Wojciech, Eduardo Bossone, Caterina Driussi, Francesco Antonini-Canterin, Paolo Palatini, Krystyna Loboz-Grudzien
OBJECTIVES: To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1 ) and late systole (W2 ). METHODS: A total of 145 untreated hypertensive patients were compared with 145 age- and sex-matched normotensive subjects. They underwent comprehensive echocardiography and WI analysis...
November 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925417/effects-of-temperature-on-multiparametric-evaluation-of-hindlimb-ischemia-with-dynamic-fluorescence-imaging
#13
Wenjuan Cai, Huizhi Guang, Chuangjian Cai, Jianwen Luo
Quantitative evaluation of hindlimb ischemia is essential for early diagnosis and therapy of peripheral arterial disease (PAD). Dynamic imaging using near-infrared (NIR) fluorophore indocyanine green (ICG) is a noninvasive and effective tool to monitor multiple vascular parameters including perfusion rate (PR), perfusion vascular density (PVD) and hemodynamics. It has been previously demonstrated that temperature changes could lead to significant variations of blood flow rate and vascular perfusion. In this paper, multiparametric evaluation of hindlimb ischemia was performed at different temperatures...
December 7, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27925239/physiologically-based-pharmacokinetic-modeling-revealed-minimal-codeine-intestinal-metabolism-in-first-pass-removal-in-rats
#14
Keumhan Noh, Shu Chen, Qi J Yang, K Sandy Pang
The physiologically-based model with segregated flow to the intestine (SFM-PBPK; partial, lower flow to enterocyte region vs. greater flow to serosal region) was found to describe first-pass glucuronidation of morphine (M) to morphine-3β-glucuronide (MG) in rats after intraduodenal (ID) and intravenous (IV) administration better than the traditional model (TM), for which a single intestinal flow perfused the whole of the intestinal tissue. The SFM described a greater extent of intestinal M glucuronidation for ID vs...
December 7, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27925032/numerical-study-of-wake-characteristics-in-a-horizontal-axis-hydrokinetic-turbine
#15
Paulo A S F Silva, Taygoara F DE Oliveira, Antonio C P Brasil, Jerson R P Vaz
Over the years most studies on wake characteristics have been devoted to wind turbines, while few works are related to hydrokinetic turbines. Among studies applied to rivers, depth and width are important parameters for a suitable design. In this work, a numerical study of the wake in a horizontal-axis hydrokinetic turbine is performed, where the main objective is an investigation on the wake structure, which can be a constraining factor in rivers. The present paper uses the Reynolds Averaged Navier Stokes (RANS) flow simulation technique, in which the Shear-Stress Transport (SST) turbulent model is considered, in order to simulate a free hydrokinetic runner in a typical river flow...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27924972/protective-mechanisms-of-purified-polyphenols-from-pinecones-of-pinus-koraiensis-on-spleen-tissues-in-tumor-bearing-s180-mice-in-vivo
#16
Juanjuan Yi, Cuilin Cheng, Xiaoyu Li, Haitian Zhao, Hang Qu, Zhenyu Wang, Lu Wang
The previous study evaluated the antitumor activity and the underlying mechanism of the purified polyphenols from pinecones of Pinus koraiensis (PPP-40) using a tumor-bearing S180 mice model. This study was designed to evaluate the protective effects of PPP-40 on spleen tissues of S180 mice in vivo. Pretreatment with PPP-40 (150 mg per kg BW per D) could significantly inhibit tumor growth, enhance spleen index and prevent the decline of haematological parameters of S180 mice induced by the tumor microenvironment...
December 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27924174/feasibility-study-of-computational-fluid-dynamics-simulation-of-coronary-computed-tomography-angiography-based-on-dual-source-computed-tomography
#17
Jing Lu, Jie Yu, Heshui Shi
BACKGROUND: Adding functional features to morphological features offers a new method for non-invasive assessment of myocardial perfusion. This study aimed to explore technical routes of assessing the left coronary artery pressure gradient, wall shear stress distribution and blood flow velocity distribution, combining three-dimensional coronary model which was based on high resolution dual-source computed tomography (CT) with computational fluid dynamics (CFD) simulation. METHODS: Three cases of no obvious stenosis, mild stenosis and severe stenosis in left anterior descending (LAD) were enrolled...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27923974/acute-vascular-effects-of-carbonated-warm-water-lower-leg-immersion-in-healthy-young-adults
#18
Shigehiko Ogoh, Ryohei Nagaoka, Takamasa Mizuno, Shohei Kimura, Yasuhiro Shidahara, Tomomi Ishii, Michinari Kudoh, Erika Iwamoto
Endothelial dysfunction is associated with increased cardiovascular mortality and morbidity; however, this dysfunction may be ameliorated by several therapies. For example, it has been reported that heat-induced increases in blood flow and shear stress enhance endothelium-mediated vasodilator function. Under these backgrounds, we expect that carbon dioxide (CO2)-rich water-induced increase in skin blood flow improves endothelium-mediated vasodilation with less heat stress. To test our hypothesis, we measured flow-mediated dilation (FMD) before and after acute immersion of the lower legs and feet in mild warm (38°C) normal or CO2-rich tap water (1000 ppm) for 20 min in 12 subjects...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27923743/displacement-front-behavior-of-near-miscible-co2-flooding-in-decane-saturated-synthetic-sandstone-cores-revealed-by-magnetic-resonance-imaging
#19
Yu Liu, Ying Teng, Lanlan Jiang, Jiafei Zhao, Yi Zhang, Dayong Wang, Yongchen Song
It is of great importance to study the CO2-oil two-phase flow characteristic and displacement front behavior in porous media, for understanding the mechanisms of CO2 enhanced oil recovery. In this work, we carried out near miscible CO2 flooding experiments in decane saturated synthetic sandstone cores to investigate the displacement front characteristic by using magnetic resonance imaging technique. Experiments were done in three consolidated sandstone cores with the permeabilities ranging from 80 to 450mD...
December 5, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27923504/a-novel-combined-solar-pasteurizer-tio2-continuous-flow-reactor-for-decontamination-and-disinfection-of-drinking-water
#20
José María Monteagudo, Antonio Durán, Israel San Martín, Alba María Acevedo
A new combined solar plant including an annular continuous-flow compound parabolic collector (CPC) reactor and a pasteurization system was designed, built, and tested for simultaneous drinking water disinfection and chemical decontamination. The plant did not use pumps and had no electricity costs. First, water continuously flowed through the CPC reactor and then entered the pasteurizer. The temperature and water flow from the plant effluent were controlled by a thermostatic valve located at the pasteurizer outlet that opened at 80 °C...
December 3, 2016: Chemosphere
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