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https://www.readbyqxmd.com/read/28231402/ex-vivo-visualization-of-human-ciliated-epithelium-and-quantitative-analysis-of-induced-flow-dynamics-by-using-optical-coherence-tomography
#1
Yuye Ling, Xinwen Yao, Ute A Gamm, Emilio Arteaga-Solis, Charles W Emala, Michael A Choma, Christine P Hendon
BACKGROUND AND OBJECTIVE: Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. MATERIALS AND METHODS: Fourteen de-identified human tracheobronchial tissues are directly imaged by two OCT systems: one system centered at 1,300 nm with 6...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28230793/dynamic-fluid-in-a-porous-transducer-based-angular-accelerometer
#2
Siyuan Cheng, Mengyin Fu, Meiling Wang, Li Ming, Huijin Fu, Tonglei Wang
This paper presents a theoretical model of the dynamics of liquid flow in an angular accelerometer comprising a porous transducer in a circular tube of liquid. Wave speed and dynamic permeability of the transducer are considered to describe the relation between angular acceleration and the differential pressure on the transducer. The permeability and streaming potential coupling coefficient of the transducer are determined in the experiments, and special prototypes are utilized to validate the theoretical model in both the frequency and time domains...
February 21, 2017: Sensors
https://www.readbyqxmd.com/read/28229632/redox-regulation-of-mitochondrial-functional-activity-by-quinones
#3
N G Krylova, T A Kulahava, V T Cheschevik, I K Dremza, G N Semenkova, I B Zavodnik
Quinones are among the rare compounds successfully used as therapeutic agents to correct mitochondrial diseases and as specific regulators of mitochondrial function within cells. The aim of the present study was to elucidate the redox-dependent effects of quinones on mitochondrial function. The functional parameters [respiratory activity, membrane potential, and reactive oxygen species (ROS) generation] of isolated rat liver mitochondria and mitochondria in intact cells were measured in the presence of eight exogenously applied quinones that differ in lipophilicity and one-electron reduction potential...
December 2016: Physiol Int
https://www.readbyqxmd.com/read/28229626/the-role-of-hydrogen-sulfide-in-homocysteine-induced-cardiodynamic-effects-and-oxidative-stress-markers-in-the-isolated-rat-heart
#4
M Stojanovic, V Zivkovic, I Srejovic, V Jakovljevic, N Jeremic, D Djuric
This study aimed to assess the role of H2S in homocysteine-induced cardiodynamic effects in the isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique. The maximum and minimum rates of pressure in the left ventricle (dp/dt max, dp/dt min), systolic and diastolic left ventricular pressures (SLVP, DLVP), heart rate (HR), and coronary flow (CF) were measured. A spectrophotometrical method was used to measure the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), nitrite level (NO2(-)), superoxide anion radicals (O2(•-)), and hydrogen peroxide (H2O2) concentrations...
December 2016: Physiol Int
https://www.readbyqxmd.com/read/28229585/plasma-induced-decomposition-of-copper-complex-ink-for-the-formation-of-highly-conductive-copper-tracks-on-heat-sensitive-substrates
#5
Yousef Farraj, Ariel Smooha, Alexander Kamyshny, Shlomo Magdassi
The use of Cu-formate-AMP ink and low-pressure plasma for the formation of highly conductive patterns on heat sensitive plastic substrates, were studied. It was found that plasma results in decomposition of copper complex to form metallic copper without heating at high temperatures. Ink composition and plasma parameters (pre-drying conditions, plasma treatment duration, gas type and flow rate) were optimized to obtain uniform conductive metallic films. The morphology and electrical characteristics of these films were evaluated...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28228546/a-minimal-actomyosin-based-model-predicts-the-dynamics-of-filopodia-on-neuronal-dendrites
#6
Olena O Marchenko, Sulagna Das, Ji Yu, Igor L Novak, Vladimir I Rodionov, Nadia Efimova, Tatyana Svitkina, Charles W Wolgemuth, Leslie M Loew
Dendritic filopodia are actin-filled dynamic subcellular structures that sprout on neuronal dendrites during neurogenesis. The exploratory motion of the filopodia is crucial for synaptogenesis but the underlying mechanisms are poorly understood. To study the filopodial motility, we collected and analyzed image data on filopodia in cultured rat hippocampal neurons. We hypothesized that mechanical feedback among the actin retrograde flow, myosin activity and substrate adhesion gives rise to various filopodial behaviors...
February 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28228407/retrobulbar-ocular-blood-flow-changes-measured-by-colour-doppler-imaging-after-intra-arterial-chemotherapy-in-retinoblastoma
#7
Kang Xue, Ailin Liu, Ren Hui, Jing Zhang, Jiang Qian
PURPOSE: To evaluate the effects of intra-arterial chemotherapy on retrobulbar blood flow parameters in patients with retinoblastoma. METHODS: This was a case-control study. 20 eyes of 10 patients with unilateral retinoblastoma that were treated with intra-arterial chemotherapy were evaluated using colour Doppler imaging. The peak systolic and end-diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. The pulsatility and resistance indices were calculated automatically...
February 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28227682/development-of-ocular-viscosity-characterization-method
#8
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227638/simulation-of-fluid-environment-using-a-robotic-orthosis-on-human-lower-extremity-for-therapeutic-purposes
#9
Tayfun Efe Ertop, Tolga Yuksel, Erhan Ilhan Konukseven, Tayfun Efe Ertop, Tolga Yuksel, Erhan Ilhan Konukseven, Tolga Yuksel, Erhan Ilhan Konukseven, Tayfun Efe Ertop
Rehabilitation under water is a viable physical rehabilitation option, but it has some limitations in terms of adapting to needs of each patient. In addition, its facility requirements are relatively high. Simulating the fluid environment using a robotic system would enable therapists adjust various parameters so that the therapy is tailored to the patient's unique state. Also, using a robotic system instead might be less costly and easily reachable. In this study, human lower extremity movement in fluids is modeled...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227463/hemodynamic-effects-of-synchronizing-an-intra-aortic-vad-in-reverse-rotation-control-with-left-ventricle-a-mock-loop-study
#10
Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Richard A McMahon, Daniel L Timms, Po-Lin Hsu, Yaxin Wang, P Alex Smith
The IntraVAD is an intra-aortic left ventricular assist device (LVAD) to be located in the ascending aorta. In order to enhance unloading and promote coronary flow for the left ventricle (LV), an operating mechanism, reverse-rotation control (RRc) mode, has been developed for the IntraVAD and tested in vitro in a mock circulation loop (MCL). The RRc mode consists of forward rotation (FR) and reverse rotation (RR). The synchronization between the IntraVAD and the LV was studied to offload the ventricle more effectively and to improve myocardial perfusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227457/evaluation-of-periodic-breathing-in-respiratory-flow-signal-of-elderly-patients-using-svm-and-linear-discriminant-analysis
#11
Sara Argerich, Sergio Herrera, Salvador Benito, Beatriz F Giraldo, Sara Argerich, Sergio Herrera, Salvador Benito, Beatriz F Giraldo, Beatriz F Giraldo, Salvador Benito, Sara Argerich, Sergio Herrera
Aging population is a major concern that is reflected in the increase of chronic diseases. Heart Failure (HF) is one of the most common chronic diseases of elderly people that is punctuated with acute episodes, which result in hospitalization. The periodic modulation of the amplitude of the breathing pattern is proved to be one of the multiple symptoms of an acute episode, and thus, the features extracted from its characterization contribute in the improvement of the first diagnosis of the clinical practice...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227452/single-source-photoplethysmograph-transducer-for-local-pulse-wave-velocity-measurement
#12
P M Nabeel, Jayaraj Joseph, Vartika Awasthi, Mohanasankar Sivaprakasam, P M Nabeel, Jayaraj Joseph, Vartika Awasthi, Mohanasankar Sivaprakasam, P M Nabeel, Mohanasankar Sivaprakasam, Vartika Awasthi, Jayaraj Joseph
Cuffless evaluation of arterial blood pressure (BP) using pulse wave velocity (PWV) has received attraction over the years. Local PWV based techniques for cuffless BP measurement has more potential in accurate estimation of BP parameters. In this work, we present the design and experimental validation of a novel single-source Photoplethysmograph (PPG) transducer for arterial blood pulse detection and cycle-to-cycle local PWV measurement. The ability of the transducer to continuously measure local PWV was verified using arterial flow phantom as well as by conducting an in-vivo study on 17 volunteers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227291/development-of-a-head-phantom-and-measurement-setup-for-lightning-effects
#13
Rene Machts, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Rene Machts, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Rene Machts
Direct lightning strikes to human heads lead to various effects ranging from Lichtenberg figures, over loss of consciousness to death. The evolution of the induced current distribution in the head is of great interest to understand the effect mechanisms. This work describes a technique to model a simplified head-phantom to investigate effects during direct lightning strike. The head-phantom geometry, conductive and dielectric parameters were chosen similar to that of a human head. Three layers (brain, skull, and scalp) were created for the phantom using agarose hydrogel doped with sodium chloride and carbon...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227283/a-method-to-detect-tortuosity-of-vessel-using-non-imaging-ultrasound-approach-in-carotid-structure
#14
Ravindra B Patil, P Krishnamoorthy, Ravindra B Patil, P Krishnamoorthy, Ravindra B Patil, P Krishnamoorthy
Stroke is a leading cause of functional impairments. The typical screening mechanism is to measure localized Peak Systolic Velocity (PSV) and diagnose impending risk associated with stoke by characterizing the PSV values. However, an accurate measurement of PSV using Doppler ultrasound is affected due to the tortuous nature of carotid artery in elder population group as the angle at which acoustic beam strikes the vessel is over or under estimated resulting in improper measure the blood flow velocity. Hence, the proposed approach estimates the degree of tortuosity of the carotid vessel and includes this as calibration parameter to compute an accurate PSV...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227105/quantifying-connectivity-in-a-physiology-based-model-using-adaptive-dynamic-causal-modelling
#15
W Xiang, C Yang, A Karfoul, R Le Bouquin Jeannes, W Xiang, C Yang, A Karfoul, R Le Bouquin Jeannes, A Karfoul, W Xiang, C Yang
This paper proposes an Adaptive Dynamic Causal Modelling based approach to detect and quantify effective connectivity in human brain structures injured by epileptic activities. The identification of the parameters in the physiology based model subtended the Electroencephalographic observations is performed by improving the optimization step in the Expectation Maximization algorithm. Considering unidirectional flow propagation, we show the efficiency of our proposed approach compared to the conventional technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227068/the-impact-of-deformation-of-an-aneurysm-model-under-pulsatile-flow-on-hemodynamic-analysis
#16
T Kawakami, H Takao, C Ichikawa, K Kamiya, Y Murayama, M Motosuke, T Kawakami, H Takao, C Ichikawa, K Kamiya, Y Murayama, M Motosuke, C Ichikawa, H Takao, K Kamiya, M Motosuke, T Kawakami, Y Murayama
Hemodynamic analysis of cerebral aneurysms has been widely carried out to clarify the mechanisms of their growth and rupture. In several cases, patient-specific aneurysm models made of transparent polymers have been used. Even though periodic changes in aneurysms due to the pulsation of blood flow could be important, the deformation of the model geometry and its effect on hemodynamic evaluation has not been fully investigated. In addition, the fabrication accuracy of aneurysm models has not been evaluated even though it may affect the hemodynamic parameters to be analyzed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226987/blood-viscosity-monitoring-during-cardiopulmonary-bypass-based-on-pressure-flow-characteristics-of-a-newtonian-fluid
#17
Shigeyuki Okahara, Zu Soh, Shinya Takahashi, Taijiro Sueda, Toshio Tsuji, Shigeyuki Okahara, Zu Soh, Shinya Takahashi, Taijiro Sueda, Toshio Tsuji, Zu Soh, Toshio Tsuji, Shinya Takahashi, Taijiro Sueda, Shigeyuki Okahara
We proposed a blood viscosity estimation method based on pressure-flow characteristics of oxygenators used during cardiopulmonary bypass (CPB) in a previous study that showed the estimated viscosity to correlate well with the measured viscosity. However, the determination of the parameters included in the method required the use of blood, thereby leading to high cost of calibration. Therefore, in this study we propose a new method to monitor blood viscosity, which approximates the pressure-flow characteristics of blood considered as a non-Newtonian fluid with characteristics of a Newtonian fluid by using the parameters derived from glycerin solution to enable ease of acquisition...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226721/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#18
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Stuart Norris, Brett Cowan, Pau Medrano-Gracia, Kathleen Gilbert, Mark Webster, Alistair Young, Susann Beier, John Cater, John Ormiston
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226554/effects-of-a-non-thermal-plasma-needle-device-on-hpv-16-positive-cervical-cancer-cell-viability-in-vitro
#19
Hollie A Ryan, Johanna Neuber, Shutong Song, Stephen J Beebe, Chunqi Jiang, Hollie A Ryan, Johanna Neuber, Shutong Song, Stephen J Beebe, Chunqi Jiang, Shutong Song, Johanna Neuber, Chunqi Jiang, Stephen J Beebe, Hollie A Ryan
Non-thermal atmospheric pressure plasma has been demonstrated to inactivate a wide range of surface-dwelling pathogenic microorganisms including airborne viral particles, vegetative bacteria and bacterial spores. This shows the promise of plasma-based decontamination procedures for broad-spectrum sterilization and disinfection and promotes the in-depth and systematic study of how plasma treatment conditions relate to pathogen inactivation efficiency. A wide knowledge gap nonetheless exists regarding whether certain plasma parameters and exposure conditions can alter the resistance of virus-linked cancer cells to treatment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226320/impaired-pulmonary-function-in-patients-with-psoriasis
#20
Didem Didar Balci, Ebru Celik, Sebahat Genc, Muhammet Murat Çelik, Mehmet Ugur Inan
BACKGROUND: Psoriasis is associated with chronic obstructive pulmonary disease. There is no study on the spirometric pulmonary function testing in patients with psoriasis. OBJECTIVE: The aim of this study was to compare the spirometric parameters in patients with psoriasis and controls. METHODS: Ninety-six patients with psoriasis and 60 sex- and age-matched control subjects were included in this study. Spirometric pulmonary function testing, including percent forced vital capacity (FVC%), percent forced expiratory volume in the 1st second (FEV1%), forced expiratory flow at 25-75% of FVC (FEF25-75%), and FEV1/FVC ratio, was performed in all study subjects...
February 23, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
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