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https://www.readbyqxmd.com/read/29474463/the-development-and-validation-of-different-decision-making-tools-to-predict-urine-culture-growth-out-of-urine-flow-cytometry-parameter
#1
Martin Müller, Ruth Seidenberg, Sabine K Schuh, Aristomenis K Exadaktylos, Clyde B Schechter, Alexander B Leichtle, Wolf E Hautz
OBJECTIVE: Patients presenting with suspected urinary tract infection are common in every day emergency practice. Urine flow cytometry has replaced microscopic urine evaluation in many emergency departments, but interpretation of the results remains challenging. The aim of this study was to develop and validate tools that predict urine culture growth out of urine flow cytometry parameter. METHODS: This retrospective study included all adult patients that presented in a large emergency department between January and July 2017 with a suspected urinary tract infection and had a urine flow cytometry as well as a urine culture obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29474361/fermented-whey-based-product-improves-the-quality-of-life-of-males-with-moderate-lower-urinary-tract-symptoms-a-randomized-double-blind-study
#2
Kristo Ausmees, Kersti Ehrlich-Peets, Mirjam Vallas, Andre Veskioja, Kadi Rammul, Aune Rehema, Mihkel Zilmer, Epp Songisepp, Tiiu Kullisaar
PURPOSE: The purpose of this research was to evaluate the effect of a specific fermented whey product on lower urinary tract symptoms, main prostate related indices and oxidative stress/inflammatory markers in urine and seminal plasma in men with moderate dysuric symptoms. An additional purpose was to clarify associations between different parameters with special emphasis on pain. METHODS: This was a prospective randomized double-blind 4-weeks study on men with moderate lower urinary tract symptoms who underwent the evaluation for quality of life at the baseline and at the end of the study...
2018: PloS One
https://www.readbyqxmd.com/read/29474357/effects-of-flow-rate-on-the-migration-of-different-plasticizers-from-pvc-infusion-medical-devices
#3
Lise Bernard, Teuta Eljezi, Hélène Clauson, Céline Lambert, Yassine Bouattour, Philip Chennell, Bruno Pereira, Valérie Sautou
Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated...
2018: PloS One
https://www.readbyqxmd.com/read/29473675/contemporary-oxygenator-design-shear-stress-related-oxygen-and-carbon-dioxide-transfer
#4
Rik H J Hendrix, Yuri M Ganushchak, Patrick W Weerwind
Design of contemporary oxygenators requires better understanding of the influence of hydrodynamic patterns on gas exchange. A decrease in blood path width or an increase in intraoxygenator turbulence for instance, might increase gas transfer efficiency but it will increase shear stress as well. The aim of this clinical study was to examine the association between shear stress and oxygen and carbon dioxide transfer in different contemporary oxygenators during cardiopulmonary bypass (CPB). The effect of additional parameters related to gas transfer efficiency, that is, blood flow, gas flow, sweep gas oxygen fraction (FiO2 ), hemoglobin concentration, the amount of hemoglobin pumped through the oxygenator per minute-Qhb, and shunt fraction were contemplated as well...
February 23, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29473534/the-enriched-proanthocyanidin-extract-of-ligaria-cuneifolia-shows-a-marked-hypocholesterolemic-effect-in-rats-fed-with-cholesterol-enriched-diet
#5
Jose Enrique Gonzalvez, Gloria Garcia, Sebastian Galliano, Alicia Dominighini, Leda Urli, Juan Monti, Maria Teresa Ronco, Daniel Frances, Marcelo Wagner, Cristina Ester Carnovale, Alejandra Nora Luquita
BACKGROUND: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. OBJECTIVE: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma Cho levels, the hemorheological parameters, and biliary secretion. METHOD: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days...
February 22, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29473072/numerical-experimental-observation-of-shape-bistability-of-red-blood-cells-flowing-in-a-microchannel
#6
Achim Guckenberger, Alexander Kihm, Thomas John, Christian Wagner, Stephan Gekle
Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. Predicting the realized shapes is a complex field as they are determined by the intricate interplay between the flow conditions and the membrane mechanics. In this work we construct the shape phase diagram of a single red blood cell with a physiological viscosity ratio flowing in a microchannel. We use both experimental in vitro measurements as well as 3D numerical simulations to complement the respective other one...
February 23, 2018: Soft Matter
https://www.readbyqxmd.com/read/29472993/life-histories-predict-genetic-diversity-and-population-structure-within-three-species-of-octopus-targeted-by-small-scale-fisheries-in-northwest-mexico
#7
José F Domínguez-Contreras, Adrian Munguia-Vega, Bertha P Ceballos-Vázquez, Marcial Arellano-Martínez, Francisco J García-Rodríguez, Melanie Culver, Hector Reyes-Bonilla
The fishery for octopus in Northwest Mexico has increased to over 2,000 tons annually, but to date the specific composition of the catch has been ignored. With at least three main species targeted by artisanal fisheries in the region with distinct life histories, the lack of basic biological information about the distribution, metapopulation size and structure of each species could impede effective fisheries management to avoid overexploitation. We tested if different life histories of three species of octopus could help predict observed patterns of genetic diversity, population dynamics, structure and connectivity and how this information could be relevant to the sustainable management of the fishery...
2018: PeerJ
https://www.readbyqxmd.com/read/29472236/assessment-of-choroidal-blood-flow-using-laser-speckle-flowgraphy
#8
Giacomo Calzetti, Klemens Fondi, Ahmed M Bata, Nikolaus Luft, Piotr A Wozniak, Katarzyna J Witkowska, Matthias Bolz, Alina Popa-Cherecheanu, René M Werkmeister, Doreen Schmidl, Gerhard Garhöfer, Leopold Schmetterer
BACKGROUND/AIMS: There is considerable interest in novel techniques to quantify choroidal blood flow (CBF) in humans. In the present study, we investigated a novel technique to measure CBF based on laser speckle flowgraphy (LSFG) in healthy subjects. METHODS: This study included 31 eyes of 31 healthy, non-smoking subjects aged between 19 and 74 years. A commercial LSFG instrument was used to measure choroidal vessel diameter (CVD) and relative flow volume (RFV) in choroidal vessels that were identified on fundus photos, an approach that was used previously only for retinal vessels...
February 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29471670/utility-of-intravoxel-incoherent-motion-magnetic-resonance-imaging-and-arterial-spin-labeling-for-recurrent-glioma-after-bevacizumab-treatment
#9
Fuminori Miyoshi, Yuki Shinohara, Atsushi Kambe, Keita Kuya, Atsushi Murakami, Masamichi Kurosaki, Toshihide Ogawa
Background Detecting recurrence of glioma on magnetic resonance imaging (MRI) is getting more and more important, especially after administration of new anti-tumor agent. However, it is still hard to identify. Purpose To examine the utility of intravoxel incoherent motion (IVIM) MRI and arterial spin labeling-cerebral blood flow (ASL-CBF) for recurrent glioma after initiation of bevacizumab (BEV) treatment. Material and Methods Thirteen patients (7 men, 6 women; age range = 41-82 years) with glioma (high grade, n = 11; low grade, n = 2) were enrolled in the study...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29470755/water-planning-in-a-mixed-land-use-mediterranean-area-point-source-abstraction-and-pollution-scenarios-by-a-numerical-model-of-varying-stream-aquifer-regime
#10
Mingxuan Du, Olivier Fouché, Elodie Zavattero, Qiang Ma, Olivier Delestre, Philippe Gourbesville
Integrated hydrodynamic modelling is an efficient approach for making semi-quantitative scenarios reliable enough for groundwater management, provided that the numerical simulations are from a validated model. The model set-up, however, involves many inputs due to the complexity of both the hydrological system and the land use. The case study of a Mediterranean alluvial unconfined aquifer in the lower Var valley (Southern France) is useful to test a method to estimate lacking data on water abstraction by small farms in urban context...
February 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29470616/automated-spect-analysis-compared-with-expert-visual-scoring-for-the-detection-of-ffr-defined-coronary-artery-disease
#11
R S Driessen, P G Raijmakers, I Danad, W J Stuijfzand, S P Schumacher, J A Leipsic, J K Min, J Knuuti, A A Lammertsma, A C van Rossum, N van Royen, S R Underwood, P Knaapen
PURPOSE: Traditionally, interpretation of myocardial perfusion imaging (MPI) is based on visual assessment. Computer-based automated analysis might be a simple alternative obviating the need for extensive reading experience. Therefore, the aim of the present study was to compare the diagnostic performance of automated analysis with that of expert visual reading for the detection of obstructive coronary artery disease (CAD). METHODS: 206 Patients (64% men, age 58...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29470603/cardiac-gated-intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-for-the-investigation-of-intracranial-cerebrospinal-fluid-dynamics-in-the-lateral-ventricle-a-feasibility-study
#12
Eddie Surer, Cristina Rossi, Anton S Becker, Tim Finkenstaedt, Moritz C Wurnig, Antonios Valavanis, Sebastian Winklhofer
PURPOSE: Intravoxel incoherent motion (IVIM) in diffusion-weighted magnetic resonance imaging (DW-MRI) attributes the signal attenuation to the molecular diffusion and to a faster pseudo-diffusion. Purpose of the study was to demonstrate the feasibility of IVIM for the investigation of intracranial cerebrospinal fluid (CSF) dynamics. METHODS: Cardiac-gated DW-MRI images with fifteen b-values (0-1300s/mm2 ) along three orthogonal directions (mediolateral (ML), anteroposterior (AP), and craniocaudal (CC)) were acquired during maximum systole and diastole in 10 healthy volunteers (6 males, mean age 36 ± 15 years)...
February 22, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29469896/wavefront-reconstruction-of-a-non-coaxial-diffraction-model-in-a-lens-system
#13
Xin Jin, Xuemei Ding, Jiubin Tan, Cheng Shen, Shutian Liu, Zhengjun Liu
To reconstruct a wavefront in a non-coaxial lens system, we propose a diffraction model using the Fresnel integral. Inclination angle is the newly included parameter in the mathematical formula describing beam propagation. It is determined through two ways in this paper, which are correlation operation and optical flow method. Furthermore, the multi-image phase retrieval is incorporated to reconstruct the complex optical field of sample from an overdetermined dataset. The combination is much closer to the actual situation and thus more practical...
February 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469601/the-effects-of-netarsudil-ophthalmic-solution-on-aqueous-humor-dynamics-in-a-randomized-study-in-humans
#14
Arash Kazemi, Jay W McLaren, Casey C Kopczynski, Theresa G Heah, Gary D Novack, Arthur J Sit
PURPOSE: Netarsudil, an inhibitor of Rho kinase and a norepinephrine transporter, has been shown to lower elevated intraocular pressure (IOP) in controlled studies of patients with open-angle glaucoma and ocular hypertension, and in healthy volunteers. The mechanism of this ocular hypotensive effect in humans is unknown. METHODS: The objective of this study was to evaluate the effect of netarsudil 0.02% on aqueous humor dynamics (AHD) parameters. In this double-masked, vehicle-controlled, paired-eye comparison study, 11 healthy volunteers received topical netarsudil ophthalmic solution 0...
February 22, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29467758/predicting-early-viral-control-under-direct-acting-antiviral-therapy-for-chronic-hepatitis-c-virus-using-pretreatment-immunological-markers
#15
James A Hutchinson, Kilian Weigand, Akinbami Adenugba, Katharina Kronenberg, Jan Haarer, Florian Zeman, Paloma Riquelme, Matthias Hornung, Norbert Ahrens, Hans J Schlitt, Edward K Geissler, Jens M Werner
Recent introduction of all-oral direct-acting antiviral (DAA) treatment has revolutionized care of patients with chronic hepatitis C virus (HCV) infection. Regrettably, the high cost of DAA treatment is burdensome for healthcare systems and may be prohibitive for some patients who would otherwise benefit. Understanding how patient-related factors influence individual responses to DAA treatment may lead to more efficient prescribing. In this observational study, patients with chronic HCV infection were comprehensively monitored by flow cytometry to identify pretreatment immunological variables that predicted HCV RNA negativity within 4 weeks of commencing DAA treatment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467481/the-mechanistic-causes-of-peripheral-intravenous-catheter-failure-based-on-a-parametric-computational-study
#16
Russell Piper, Peter J Carr, Lachlan J Kelsey, Andrew C Bulmer, Samantha Keogh, Barry J Doyle
Peripheral intravenous catheters (PIVCs) are the most commonly used invasive medical device, yet up to 50% fail. Many pathways to failure are mechanistic and related to fluid mechanics, thus can be investigated using computational fluid dynamics (CFD). Here we used CFD to investigate typical PIVC parameters (infusion rate, catheter size, insertion angle and tip position) and report the hemodynamic environment (wall shear stress (WSS), blood damage, particle residence time and venous stasis volumes) within the vein and catheter, and show the effect of each PIVC parameter on each hemodynamic measure...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467184/low-catalase-expression-confers-redox-hypersensitivity-and-identifies-an-indolent-clinical-behavior-in-cll
#17
Chiara Cavallini, Roberto Chignola, Ilaria Dando, Omar Perbellini, Elda Mimiola, Ornella Lovato, Carlo Laudanna, Giovanni Pizzolo, Massimo Donadelli, Maria Teresa Scupoli
B-cell receptor (BCR) signaling is a key determinant of variable clinical behavior and a target for therapeutic interventions in chronic lymphocytic leukemia (CLL). Endogenously produced H2 O2 is thought to fine-tune the BCR signaling by reversibly inhibiting phosphatases. However, little is known about how CLL cells sense and respond to such redox cues and what impact they have on CLL. We characterized the response of BCR signaling proteins to exogenous H2 O2 in cells from CLL patients using phospho-specific flow cytometry...
February 21, 2018: Blood
https://www.readbyqxmd.com/read/29467132/rapid-diagnostic-test-for-antenatal-syphilis-screening-in-low-income-and-middle-income-countries-a-systematic-review-and-meta-analysis
#18
Carmen Phang Romero Casas, Marrissa Martyn-St James, Jean Hamilton, Daniel S Marinho, Rodolfo Castro, Sue Harnan
OBJECTIVES: To undertake a systematic review and meta-analysis to evaluate the test performance including sensitivity and specificity of rapid immunochromatographic syphilis (ICS) point-of-care (POC) tests at antenatal clinics compared with reference standard tests (non-treponemal (TP) and TP tests) for active syphilis in pregnant women. METHODS: Five electronic databases were searched (PubMed, EMBASE, CRD, Cochrane Library and LILACS) to March 2016 for diagnostic accuracy studies of ICS test and standard reference tests for syphilis in pregnant women...
February 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29467056/review-integrating-a-semen-quality-control-program-and-sire-fertility-at-a-large-artificial-insemination-organization
#19
B R Harstine, M D Utt, J M DeJarnette
The technology available to assess sperm population characteristics has advanced greatly in recent years. Large artificial insemination (AI) organizations that sell bovine semen utilize many of these technologies not only for novel research purposes, but also to make decisions regarding whether to sell or discard the product. Within an AI organization, the acquisition, interpretation and utilization of semen quality data is often performed by a quality control department. In general, quality control decisions regarding semen sales are often founded on the linkages established between semen quality and field fertility...
February 22, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29466988/blood-flow-characteristics-of-diabetic-patients-with-complications-detected-by-optical-measurement
#20
Yuri An, Yujung Kang, Jungsul Lee, Chulwoo Ahn, Kihwan Kwon, Chulhee Choi
BACKGROUND: Diabetes mellitus (DM) is one of the most common diseases worldwide. Uncontrolled and prolonged hyperglycemia can cause diabetic complications, which reduce the quality of life of patients. Diabetic complications are common in DM patients. Because it is impossible to completely recover from diabetic complications, it is important for early detection. In this study, we suggest a novel method of determining blood flow characteristics based on fluorescence image analysis with indocyanine green and report that diabetic complications have unique blood flow characteristics...
February 21, 2018: Biomedical Engineering Online
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