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https://www.readbyqxmd.com/read/29908703/rate-constant-determination-of-interconverting-enantiomers-by-chiral-chromatography-using-a-stochastic-model
#1
Annamária Sepsey, Dóra Rita Németh, Gábor Németh, Attila Felinger
It may happen under the conditions employed that enantiomers interconvert to each other. In this case, obviously, the kinetics of the process is to be examined. When enantiomers dynamically interconvert to each other during the separation process, a plateau is observed between the adjacent peaks (so-called Batman peak appears). The peak shape depends on the rate constant of this dynamic reaction. A novel stochastic model was derived which takes both the separation and the interconversion into account at the molecular level - thus the effects of the parameters affecting the separation can be investigated...
June 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#2
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908395/a-novel-compliance-pressure-loop-approach-to-quantify-arterial-compliance-in-systole-and-in-diastole
#3
Mehmet Kaya, Vignesh Balasubramanian, Amit Patel, Yueya Ge, John K-J Li
Arterial compliance has been recognized as a critical parameter in governing pulsatile flow dynamics. It has traditionally been assumed constant throughout the cardiac cycle and its computation has been based either on the classic Windkessel model (C) in diastole or the stroke volume over pulse pressure (Cv ) method in systole. Other methods using area (Cam ) or two-area (Ctam ) and exponential (C(P)exp1 ) methods were used for the cardiac cycle. We proposed a novel compliance-pressure loop (CPP loop) approach for the quantification of arterial compliance and compared it to existing linear and nonlinear methods...
June 5, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908332/enhanced-nanoparticle-uptake-into-virus-infected-cells-could-nanoparticles-be-useful-in-antiviral-therapy
#4
Yasmin Abo-Zeid, Richard A Urbanowicz, Brian J Thomson, William L Irving, Alexander W Tarr, Martin C Garnett
Virus infections cause diseases of different severity ranged from mild infection e.g. common cold into life threating diseases e.g. Human Immunodeficiency virus (HIV), Hepatitis B. Virus infections represent 44% of newly emerging infections. Although there are many efficient antiviral agents, they still have drawbacks due to accumulation at off target organs and developing of virus resistance due to virus mutation. Therefore, developing a delivery system that can selectively target drug into affected organs and avoid off target accumulation would be a highly advantageous strategy to improve antiviral therapy...
June 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29907276/device-management-and-flow-optimization-on-left-ventricular-assist-device-support
#5
REVIEW
Inna Tchoukina, Melissa C Smallfield, Keyur B Shah
The authors discuss principles of continuous flow left ventricular assist device (LVAD) operation, basic differences between the axial and centrifugal flow designs and hemodynamic performance, normal LVAD physiology, and device interaction with the heart. Systematic interpretation of LVAD parameters and recognition of abnormal patterns of flow and pulsatility on the device interrogation are necessary for clinical assessment of the patient. Optimization of pump flow using LVAD parameters and echocardiographic and hemodynamics guidance are reviewed...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29906980/discrete-unified-gas-kinetic-scheme-for-all-knudsen-number-flows-iii-binary-gas-mixtures-of-maxwell-molecules
#6
Yue Zhang, Lianhua Zhu, Ruijie Wang, Zhaoli Guo
Recently a discrete unified gas kinetic scheme (DUGKS) in a finite-volume formulation based on the Boltzmann model equation has been developed for gas flows in all flow regimes. The original DUGKS is designed for flows of single-species gases. In this work, we extend the DUGKS to flows of binary gas mixtures of Maxwell molecules based on the Andries-Aoki-Perthame kinetic model [P. Andries et al., J. Stat. Phys. 106, 993 (2002)JSTPBS0022-471510.1023/A:1014033703134. A particular feature of the method is that the flux at each cell interface is evaluated based on the characteristic solution of the kinetic equation itself; thus the numerical dissipation is low in comparison with that using direct reconstruction...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906949/scale-invariant-feature-extraction-of-neural-network-and-renormalization-group-flow
#7
Satoshi Iso, Shotaro Shiba, Sumito Yokoo
Theoretical understanding of how a deep neural network (DNN) extracts features from input images is still unclear, but it is widely believed that the extraction is performed hierarchically through a process of coarse graining. It reminds us of the basic renormalization group (RG) concept in statistical physics. In order to explore possible relations between DNN and RG, we use the restricted Boltzmann machine (RBM) applied to an Ising model and construct a flow of model parameters (in particular, temperature) generated by the RBM...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906943/perspectives-on-scaling-and-multiscaling-in-passive-scalar-turbulence
#8
Tirthankar Banerjee, Abhik Basu
We revisit the well-known problem of multiscaling in substances passively advected by homogeneous and isotropic turbulent flows or passive scalar turbulence. To that end we propose a two-parameter continuum hydrodynamic model for an advected substance concentration θ, parametrized jointly by y and y[over ¯], that characterize the spatial scaling behavior of the variances of the advecting stochastic velocity and the stochastic additive driving force, respectively. We analyze it within a one-loop dynamic renormalization group method to calculate the multiscaling exponents of the equal-time structure functions of θ...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906868/galilean-invariant-preconditioned-central-moment-lattice-boltzmann-method-without-cubic-velocity-errors-for-efficient-steady-flow-simulations
#9
Farzaneh Hajabdollahi, Kannan N Premnath
Lattice Boltzmann (LB) models used for the computation of fluid flows represented by the Navier-Stokes (NS) equations on standard lattices can lead to non-Galilean-invariant (GI) viscous stress involving cubic velocity errors. This arises from the dependence of their third-order diagonal moments on the first-order moments for standard lattices, and strategies have recently been introduced to restore Galilean invariance without such errors using a modified collision operator involving corrections to either the relaxation times or the moment equilibria...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906454/standardization-of-sampling-and-sample-preparation-for-analysis-of-human-monocyte-subsets-in-peripheral-blood
#10
Ida Marie Rundgren, Øystein Bruserud, Anita Ryningen, Elisabeth Ersvær
INTRODUCTION: Monocytes are important for innate immunity and include the classical (CD14bright CD16negative ), intermediate (CD14bright CD16dim ) and non-classical (CD14dim CD16bright ) monocyte subsets. The quantification of these functionally different subsets in peripheral blood may become useful for diagnosis and follow-up in human diseases. The aim of the present study was to investigate how different pre-analytical parameters influence analysis of monocyte subsets in peripheral blood samples...
June 12, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29906283/classification-of-red-blood-cell-shapes-in-flow-using-outlier-tolerant-machine-learning
#11
Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint
The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary Poiseuille flow, we overcome this drawback by introducing a convolutional neural regression network for an automatic, outlier tolerant shape classification. From our experiments we expect two stable geometries: the so-called 'slipper' and 'croissant' shapes depending on the prevailing flow conditions and the cell-intrinsic parameters...
June 15, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29904949/combination-with-mir-124a-improves-the-protective-action-of-bmscs-in-rescuing-injured-rat-podocytes-from-abnormal-apoptosis-and-autophagy
#12
Jiping Sun, Jing Lv, Wenjing Zhang, Lili Li, Jia Lv, Yingzhou Geng, Aiping Yin
This in vitro study was performed to identify the role of miR-124a in bone marrow stromal stem cells (BMSCs) therapy for H2 O2 -induced rat podocyte injury, and determine whether combination treatment with miR-124a could improve the protective effect of BMSCs. Cell viability of podocytes was detected by CCK-8 assay. Detection of ROS level, apoptotic rate, and autophagy rate was carried out using flow cytometry assays. Oxidative stress parameters were analyzed using the ELISA assays. MiR-124a and mRNA levels were determined using real-time PCR...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904680/hydro-geometrical-data-analyses-of-river-atuwara-at-ado-odo-otta-ogun-state
#13
Adebanji S Ogbiye, Olumuyiwa O Onakunle, David O Omole
The dataset analyzed in this article contains spatial and temporal values of the hydro-geometric parameters of River Atuwara. The hydro-geometrical data analyses of various sampling point on River Atuwara was examined and their geometric properties were taken with the use of a paddled boat, depth meter and global positioning system (GPS). The co-ordinates, width, depth, slopes, area, velocity, flow were gotten in-situ while the area and wetted perimeter were computed ex-situ. The statistical relationships between separate variables were considered using scatter plots and regression line equations...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904356/coronary-blood-flow-is-increased-in-rv-hypertrophy-but-the-shape-of-normalized-waves-is-preserved-throughout-the-arterial-tree
#14
Yunlong Huo, Ghassan S Kassab
A pulsatile hemodynamic analysis was carried out in the right coronary arterial (RCA) tree of control and RV hypertrophy (RVH) hearts. The shape of flow and wall shear stress (WSS) waves was hypothesized to be maintained throughout the RCA tree in RVH (i.e., similar patterns of normalized flow and WSS waves in vessels of various sizes). Consequently, we reconstructed the entire RCA tree down to the first capillary bifurcation of control and RVH hearts based on measured morphometric data. A Womersley-type model was used to compute the flow and WSS waves in the tree...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29904131/quantitative-study-of-abdominal-blood-flow-patterns-in-patients-with-aortic-dissection-by-4-dimensional-flow-mri
#15
Dongting Liu, Zhanming Fan, Yu Li, Nan Zhang, Zhonghua Sun, Jing An, Aurélien F Stalder, Andreas Greiser, Jiayi Liu
The purpose of this study is to evaluate the hemodynamic characteristics of the true lumen (TL) and the false lumen (FL) in 16 patients with aortic dissection (AD) using 4D flow magnetic resonance imaging (MRI) and thoracic and abdominal computed tomography (CT) angiography. The quantitative parameters that were measured in the TL and FL included velocity and flow. The mean area and regurgitant fraction of the TL were significantly lesser at all four levels (p < 0.05); the average through-plane velocity, peak velocity magnitude, average net flow, peak flow, and net forward volume in the TL were considerably higher (p < 0...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903721/visual-attention-on-a-respiratory-function-monitor-during-simulated-neonatal-resuscitation-an-eye-tracking-study
#16
Trixie A Katz, Danielle D Weinberg, Claire E Fishman, Vinay Nadkarni, Patrice Tremoulet, Arjan B Te Pas, Aleksandra Sarcevic, Elizabeth E Foglia
OBJECTIVE: A respiratory function monitor (RFM) may improve positive pressure ventilation (PPV) technique, but many providers do not use RFM data appropriately during delivery room resuscitation. We sought to use eye-tracking technology to identify RFM parameters that neonatal providers view most commonly during simulated PPV. DESIGN: Mixed methods study. Neonatal providers performed RFM-guided PPV on a neonatal manikin while wearing eye-tracking glasses to quantify visual attention on displayed RFM parameters (ie, exhaled tidal volume, flow, leak)...
June 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29903518/3d-echocardiography-derived-right-ventricular-function-is-associated-with-right-ventricular-failure-and-mid-term-survival-after-left-ventricular-assist-device-implantation
#17
Harry Magunia, Clemens Dietrich, Harald F Langer, David Schibilsky, Christian Schlensak, Peter Rosenberger, Martina Nowak-Machen
BACKGROUND: Right heart failure remains a major cause of morbidity and mortality after left ventricular assist device (LVAD) implantation. Multiple 2D echocardiography derived parameters are associated with right ventricular failure (RV failure), but none of them has been proven to be a reliable predictor to date. We hypothesized that novel 3D-echocardiography (3DE) based parameters are associated with RV failure and predict long term outcome in patients undergoing LVAD implantation. METHODS: This single-center study retrospectively enrolled 26 patients undergoing continuous-flow LVAD implantation...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29903501/projections-of-progress-toward-the-80-bachelor-of-science-in-nursing-recommendation-and-strategies-to-accelerate-change
#18
Joanne Spetz
BACKGROUND: In 2011, the Institute of Medicine recommended that 80% of RNs have a bachelor's degree or higher by 2020. Progress toward this recommendation has been slow. PURPOSE: This paper presents a model that projects whether the 80% recommendation can be met within a 10-year period and estimates the impact of education changes that might accelerate progress. METHODS: A projection model for 2016 to 2026 was created using a "stock-and-flow" approach...
May 3, 2018: Nursing Outlook
https://www.readbyqxmd.com/read/29903470/adaption-of-a-parallel-path-poly-tetrafluoroethylene-nebulizer-to-an-evaporative-light-scattering-detector-optimization-and-application-to-studies-of-poly-dimethylsiloxane-oligomers-as-a-model-polymer
#19
Bernhard Durner, Thomas Ehmann, Frank-Michael Matysik
The adaption of an parallel-path poly(tetrafluoroethylene)(PTFE) ICP-nebulizer to an evaporative light scattering detector (ELSD) was realized. This was done by substituting the originally installed concentric glass nebulizer of the ELSD. The performance of both nebulizers was compared regarding nebulizer temperature, evaporator temperature, flow rate of nebulizing gas and flow rate of mobile phase of different solvents using caffeine and poly(dimethylsiloxane) (PDMS) as analytes. Both nebulizers showed similar performances but for the parallel-path PTFE nebulizer the performance was considerably better at low LC flow rates and the nebulizer lifetime was substantially increased...
June 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29903035/is-bulk-flow-plausible-in-perivascular-paravascular-and-paravenous-channels
#20
Mohammad M Faghih, M Keith Sharp
BACKGROUND: Transport of solutes has been observed in the spaces surrounding cerebral arteries and veins. Indeed, transport has been found in opposite directions in two different spaces around arteries. These findings have motivated hypotheses of bulk flow within these spaces. The glymphatic circulation hypothesis involves flow of cerebrospinal fluid from the cortical subarachnoid space to the parenchyma along the paraarterial (extramural, Virchow-Robin) space around arteries, and return flow to the cerebrospinal fluid (CSF) space via paravenous channels...
June 15, 2018: Fluids and Barriers of the CNS
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