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https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#1
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29244827/neuroligin-4x-overexpression-in-human-breast-cancer-is-associated-with-poor-relapse-free-survival
#2
Henry J Henderson, Balasubramanyam Karanam, Rajeev Samant, Komal Vig, Shree R Singh, Clayton Yates, Deepa Bedi
The molecular mechanisms involved in breast cancer progression and metastasis still remain unclear to date. It is a heterogeneous disease featuring several different phenotypes with consistently different biological characteristics. Neuroligins are neural cell adhesion molecules that have been implicated in heterotopic cell adhesion. In humans, alterations in neuroligin genes are implicated in autism and other cognitive diseases. Until recently, neuroligins have been shown to be abundantly expressed in blood vessels and also play a role implicated in the growth of glioma cells...
2017: PloS One
https://www.readbyqxmd.com/read/29244215/development-of-a-validated-liquid-chromatographic-method-for-quantification-of-sorafenib-tosylate-in-the-presence-of-stress-induced-degradation-products-and-in-biological-matrix-employing-analytical-quality-by-design-aqbd-approach
#3
Teenu Sharma, Rajneet Kaur Khurana, Atul Jain, O P Katare, Bhupinder Singh
The current research work envisages AQbD-enabled development of a simple, rapid, sensitive, specific, robust and cost-effective stability indicating reversed phase high performance liquid chromatographic (RP-HPLC) method for determining stress-induced forced degradation products of sorafenib tosylate (SFN). An Ishikawa fish bone diagram was constructed to embark upon analytical target profile (ATP) and critical analytical attributes (CAAs) i.e., peak area, theoretical plates, retention time (Rt ) and peak tailing...
December 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29244030/static-response-of-deformable-microchannels-a-comparative-modelling-study
#4
Tanmay C Shidhore, Ivan C Christov
We present a comparative modelling study of fluid--structure interactions in microchannels. Through a mathematical analysis based on plate theory and the lubrication approximation for low-Reynolds-number flow, we derive models for the flow rate--pressure drop relation for long shallow microchannels with both thin and thick deformable top walls. These relations are tested against full three-dimensional two-way-coupled fluid--structure interaction simulations. Three types of microchannels, representing different elasticity regimes and having been experimentally characterized previously, are chosen as benchmarks for our theory and simulations...
December 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29243981/assessment-of-intracranial-venous-blood-flow-after-subarachnoid-hemorrhage-a-new-approach-to-diagnose-vasospasm-with-transcranial-color-coded-duplex-sonography
#5
Florian Connolly, Stephan J Schreiber, Christoph Leithner, Georg Bohner, Peter Vajkoczy, José M Valdueza
OBJECTIVE Transcranial color-coded duplex sonography (TCCS) is a reliable tool that is used to assess vasospasm in the M1 segment of the middle cerebral artery (MCA) after subarachnoid hemorrhage (SAH). A distinct increase in blood flow velocity (BFV) is the principal criterion for vasospasm. The MCA/internal carotid artery (ICA) index (Lindegaard Index) is also widely used to distinguish between vasospasm and cerebral hyperperfusion. However, extracranial ultrasonography assessment of the neck vessels might be difficult in an intensive care unit...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243788/evaluation-on-the-impact-of-spontaneous-reperfusion-on-cardiac-muscle-of-acute-myocardial-infarction-by-three-dimensional-speckle-tracking-imaging
#6
Z-W Tao, X-W Ma, N-N Liu, N-L Tian, X-F Gao, P-X Xiao
OBJECTIVE: To explore the effect of spontaneous reperfusion (SR) on three-dimensional myocardial strain in patients with acute anterior myocardial infarction by three-dimensional speckle tracking imaging (3D-STI) technology. PATIENTS AND METHODS: Patients diagnosed with acute anterior myocardial infarction during 2013 to 2016 were consecutively selected and divided into SR group and non-spontaneous reperfusion (Non-SR) group based on whether there was SR. Patients in both groups received direct percutaneous coronary intervention (PCI) in time window...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243687/sutureless-valves-and-the-quality-of-perfusion-towards-a-goal-directed-aortic-valve-replacement
#7
Antonino S Rubino, Carmelo Mignosa
BACKGROUND: Aim of this study was to assess the potential differences in respecting the principles of goal-directed perfusion between aortic valve replacement with sutureless vs conventional stented bioprostheses. METHODS: Data from 94 consecutive patients undergoing aortic valve replacement with Perceval sutureless valve, with or without concomitant CABG, were compared to a contemporary cohort of 116 patients receiving conventional stented bioprostheses. Propensity score matching was used to reduce selection bias...
December 14, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29243191/pharmacologically-induced-impairment-of-neurovascular-coupling-responses-alters-gait-coordination-in-mice
#8
Stefano Tarantini, Andriy Yabluchanksiy, Gábor A Fülöp, Peter Hertelendy, M Noa Valcarcel-Ares, Tamas Kiss, Jonathan M Bagwell, Daniel O'Connor, Eszter Farkas, Farzaneh Sorond, Anna Csiszar, Zoltan Ungvari
There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-and-effect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC...
December 14, 2017: GeroScience
https://www.readbyqxmd.com/read/29242843/systemic-oxidoreductive-balance-and-vascular-function-in-individuals-without-clinical-manifestation-of-atherosclerosis
#9
Marcin Majer, Daniel Gackowski, Rafał Różalski, Agnieszka Siomek-Górecka, Ryszard Oliński, Jacek Budzyński
Introduction: Endothelial dysfunction is recognized as the earliest disorder in the development of atherosclerosis, in the pathogenesis of which oxidative stress plays a crucial role. The aim of this study was to determine the relationships between non-invasive parameters of vascular dysfunction and oxidative stress. Material and methods: Forty-eight individuals without clinical manifestation of atherosclerosis were studied. The plasma concentrations of the following were determined in all 48 subjects: retinol, ascorbic acid, α-tocopherol and uric acid, as well as the products of oxidative DNA damage repair: 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in blood leukocytes and urine, and 8-oxo-7,8-dihydroguanine (8-oxoGua) in urine...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29242392/benchmarking-of-sterilizing-grade-filters-with-liposome-filtration
#10
Thomas Loewe, Ramesh Mundlamuri, Thomas Loewe, Ashok Mundrigi, Sebastian Handt, Bhuwan Singh
Cytotoxic drugs can be encapsulated in liposomes vesicles, which act as drug delivery vehicles and reduce the risk of exposure of drug to healthy cells(1). The sterility of such liposome solutions is typically ensured using 0.2μm rated sterilizing grade membranes, but due to the high viscosity and low surface tension of these formulations, they can cause pre-mature blocking and increased risk of bacterial penetration through a 0.2μm sterilizing grade membrane(2). The low surface tension of liposome solutions affects the contact angle with membrane and reduces bubble point leading to bacterial penetration through the membrane...
December 14, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29242293/variable-impairment-of-platelet-functions-in-patients-with-severe-genetically-linked-immune-deficiencies
#11
Magdolna Nagy, Tom G Mastenbroek, Nadine J A Mattheij, Susanne de Witt, Kenneth J Clemetson, Janbernd Kirschner, Ansgar S Schulz, Thomas Vraetz, Carsten Speckmann, Attila Braun, Judith M E M Cosemans, Barbara Zieger, Johan W M Heemskerk
In patients with dysfunctions of the Ca2+ channel ORAI1, stromal interaction molecule 1 (STIM1) or integrin-regulating kindlin-3 (FERMT3), severe immunodeficiency is frequently linked to abnormal platelet activity. In this paper, we studied in nine rare patients, including relatives, with confirmed genetic mutations of ORAI1, STIM1 or FERMT3, platelet responsiveness by multi-parameter assessment of whole blood thrombus formation under high-shear flow conditions. In platelets isolated from 5 out of 6 patients with ORAI1 or STIM1 mutations, store-operated Ca2+ entry (SOCE) was (in)completely defective compared to control platelets...
December 14, 2017: Haematologica
https://www.readbyqxmd.com/read/29242115/using-factorial-experimental-design-to-evaluate-the-separation-of-plastics-by-froth-flotation
#12
Davide Salerno, Helga Jordão, Floriana La Marca, M Teresa Carvalho
This paper proposes the use of factorial experimental design as a standard experimental method in the application of froth flotation to plastic separation instead of the commonly used OVAT method (manipulation of one variable at a time). Furthermore, as is common practice in minerals flotation, the parameters of the kinetic model were used as process responses rather than the recovery of plastics in the separation products. To explain and illustrate the proposed methodology, a set of 32 experimental tests was performed using mixtures of two polymers with approximately the same density, PVC and PS (with mineral charges), with particle size ranging from 2 to 4 mm...
December 11, 2017: Waste Management
https://www.readbyqxmd.com/read/29241451/energetic-performance-analysis-of-staged-palliative-surgery-in-tricuspid-atresia-using-vector-flow-mapping
#13
Mao Kinoshita, Koichi Akiyama, Keiichi Itatani, Ayahiro Yamashita, Maki Ishii, Atsushi Kainuma, Yoshinobu Maeda, Takako Miyazaki, Masaaki Yamagishi, Teiji Sawa
BACKGROUND: Staged palliative surgery markedly shifts the balance of volume load on a single ventricle and pulmonary vascular bed. Blalock-Taussig shunt necessitates a single ventricle eject blood to both the systemic and pulmonary circulation. On the contrary, bidirectional cavopulmonary shunt release the single ventricle from pulmonary circulation. CASE PRESENTATION: We report a case of tricuspid atresia patient who underwent first palliative surgery and second palliative surgery...
December 14, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29241128/mobility-of-polivinylpyrrolidone-coated-silver-nanoparticles-in-tropical-soils
#14
Alejandro Yopasá Arenas, Gustavo de Souza Pessôa, Marco Aurélio Zezzi Arruda, Anne Hélène Fostier
Experiments in saturated soil columns were performed to investigate the transport and retention of 25 nm and 75 nm silver nanoparticles stabilized with polyvinylpyrrolidone (PVP-AgNPs) in two Brazilian soils (sandy and sandy-clay). The normalized concentration of the PVP-AgNPs was obtained through a flow injection analysis method based on the surface plasmon ressonance effect of the metallic nanoparticles. The use of the ultraviolet-visible spectroscopy (UV-Vis) allows a rapid and low-cost analysis. The obtained breakthrough curves (BCs) were modeled with a deterministic model of solute transport in steady conditions of water flow and considering two regions of non-physical equilibrium; this model allowed the determination of the hydrodynamic parameters...
December 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241113/concentrating-molasses-distillery-wastewater-using-biomimetic-forward-osmosis-fo-membranes
#15
N Singh, I Petrinic, C Hélix-Nielsen, S Basu, M Balakrishnan
Treatment of sugarcane molasses distillery wastewater is challenging due to the presence of complex phenolic compounds (melanoidins and polyphenols) having antioxidant properties. Due to zero liquid discharge regulations, Indian distilleries continue to explore effective treatment options. This work examines the concentration of distillery wastewater by forward osmosis (FO) using aquaporin biomimetic membranes and magnesium chloride hexahydrate (MgCl2.6H2O) as draw solution. The operational parameters viz. feed solution and draw solution flow rate and draw solution concentration were optimized using 10% v/v melanoidins model feed solution...
December 8, 2017: Water Research
https://www.readbyqxmd.com/read/29240082/study-on-the-mathematical-relationship-existing-between-single-photon-laser-doppler-flowmetry-and-diffuse-correlation-spectroscopy-with-static-background
#16
Tiziano Binzoni, Fabrizio Martelli
In the present contribution, the theoretical relationship existing between the blood flow index measured by diffuse correlation spectroscopy and single-photon laser-Doppler flowmetry (SP-LDF) is investigated. A specific mathematical description that accounts for the properties of single-photon detectors for SP-LDP was developed. Static background has also been considered and, to the best of our knowledge, this has never been included before in SP-LDF analytical theories. The comparisons were realized for two SP-LDF implementations: for "classical" and "fast" algorithms...
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29239685/in%C3%A2-vitro-angiographic-comparison-of-the-flow-diversion-performance-of-five-neurovascular-stents
#17
Ronak J Dholakia, Ari D Kappel, Andrew Pagano, Henry H Woo, Baruch B Lieber, David J Fiorella, Chander Sadasivan
Background and purpose Data differentiating flow diversion properties of commercially available low- and high-porosity stents are limited. This in vitro study applies angiographic analysis of intra-aneurysmal flow to compare the flow-diversion performance of five neurovascular devices in idealized sidewall and bifurcation aneurysm models. Methods Five commercial devices (Enterprise, Neuroform, LVIS, FRED, and Pipeline) were implanted in silicone sidewall and bifurcation aneurysm models under physiological average flow of blood analog fluid...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29239229/in-vitro-evaluation-of-single-use-digital-flexible-ureteroscopes-a-practical-comparison-for-a-patient-centered-approach
#18
Giovanni Scala Marchini, Carlos Alfredo Batagello, Manoj Monga, Fabio Cesar Miranda Torricelli, Fabio Carvalho Vicentini, Alexandre Danilovic, Miguel Srougi, William Carlos Nahas, Eduardo Mazzucchi
OBJECTIVE: to compare the manufacturing and in vitro performance characteristics of two single use flexible ureteroscopes with a permanent optical flexible ureteroscope. MATERIAL AND METHODS: Two single-use flexible ureteroscopes, LithoVue (Boston Scientific, USA) and Pusen (1rs. generation; Zhuhai Pusen Medical Technology Company Limited, China) were tested and compared with a permanent Flex-X2 ureteroscope (Karl Storz, Germany) in terms of technical characteristics, optics, deflection mechanism and additional parameters which could potentially affect surgical technique...
December 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29238833/a-potential-tool-for-the-study-of-venous-ulcers-blood-flow-responses-to-load
#19
Wu Pan, Josh Drost, Sara Roccabianca, Seungik Baek, Tamara Reid Bush
Venous ulcers are deep wounds that are located predominantly on the lower leg. They are prone to infection and once healed have a high probability of recurrence. Currently, there are no effective measures to predict and prevent venous ulcers from formation. Hence, the goal of this work was to develop a Windkessel-based model that can be used to identify hemodynamic parameters that change between healthy individuals and those with wounds. Once identified, these parameters have the potential to be used as indicators of when internal conditions change, putting the patient at higher risk for wound formation...
December 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29238818/multiscale-poroviscoelastic-compressive-properties-of-mouse-supraspinatus-tendons-are-altered-in-young-and-aged-mice
#20
Brianne Connizzo, Alan Grodzinsky
Rotator cuff disorders are one of the most common causes of shoulder pain and disability in the aging population but, unfortunately, the etiology is still unknown. One factor thought to contribute to the progression of disease is the external compression of the rotator cuff tendons, which can be significantly increased by age-related changes such as muscle weakness and poor posture. The objective of this study was to investigate the baseline compressive response of tendon and determine how this response is altered during maturation and aging...
December 13, 2017: Journal of Biomechanical Engineering
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