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dynamic parameters

Fitsum Abadi, Christophe Barbraud, Olivier Gimenez
Early-life demographic traits are poorly known, impeding our understanding of population processes and sensitivity to climate change. Survival of immature individuals is a critical component of population dynamics and recruitment in particular. However, obtaining reliable estimates of juvenile survival (i.e., from independence to first year) remains challenging, as immatures are often difficult to observe and to monitor individually in the field. This is particularly acute for seabirds, in which juveniles stay at sea and remain undetectable for several years...
October 22, 2016: Global Change Biology
Sylvia Neumann, Romain Chassefeyre, George E Campbell, Sandra E Encalada
In axons, proper localization of proteins, vesicles, organelles, and other cargoes is accomplished by the highly regulated coordination of kinesins and dyneins, molecular motors that bind to cargoes and translocate them along microtubule (MT) tracks. Impairment of axonal transport is implicated in the pathogenesis of multiple neurodegenerative disorders including Alzheimer's and Huntington's diseases. To understand how MT-based cargo motility is regulated and to delineate its role in neurodegeneration, it is critical to analyze the detailed dynamics of moving cargoes inside axons...
October 22, 2016: Traffic
Alexey N Boychuk, Dmitriy V Makarov, Alexander N Zakhlevnykh
We theoretically study the dynamics of the orientational structure of a ferronematic liquid crystal with soft planar coupling between the director and the magnetization in a rotating magnetic field. We determine critical parameters characterizing the boundary between synchronous and asynchronous rotation regimes. We show that the magnetic impurity increases the stability threshold of an asynchronous rotation regime. The critical angular velocity, the angles of the director and the magnetization rotation in each regime of orientational structure rotation are found for rigid planar coupling...
October 2016: European Physical Journal. E, Soft Matter
Alexis V Mickelson, Sampath K Gollapudi, Murali Chandra
The present study investigated the functional consequences of the human hypertrophic cardiomyopathy (HCM) mutation, A28V, in cardiac troponin T (TnT). The A28V mutation is located within the N-terminus of TnT, a region known to be important for full activation of cardiac thin filaments. The functional consequences of the A28V mutation in TnT remain unknown. Given how α- and β-myosin heavy chain (MHC) isoforms differently alter the effect of the N-terminus of TnT, we hypothesized that the A28V-induced effects would be differently modulated by α- and β-MHC isoforms...
October 21, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Hung-Yi Liu, Tanja Greene, Tsai-Yu Lin, Camron S Dawes, Murray Korc, Chien-Chi Lin
: The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor progression, but also hinders the development of therapeutic strategies against pancreatic cancer. Residing in the desmoplasia, pancreatic stellate cells (PSCs) are the major stromal cells affecting the growth and metastasis of pancreatic cancer cells by means of paracrine effects and extracellular matrix protein deposition. PSCs remain in a quiescent/dormant state until they are 'activated' by various environmental cues...
October 18, 2016: Acta Biomaterialia
Chanakan Tongsook, Johannes Niederhauser, Elena Kronegger, Grit Straganz, Peter Macheroux
The degradation of histamine catalyzed by the SAM-dependent histamine N-methyltransferase (HNMT) is critically important for the maintenance of neurological processes. Recently, two mutations in the encoding human gene were reported to give rise to dysfunctional protein variants (G60D and L208P) leading to intellectual disability. In the present study, we have expressed eight L208 variants with either apolar (L208F and L208V), polar (L208N and L208T) or charged (L208D, L208H, L208K and L208R) amino acids to define the impact of side chain variations on protein structure and function...
October 18, 2016: Biochimica et Biophysica Acta
D Papadogiannis, A Iliadi, T G Bradley, N Silikas, G Eliades, T Eliades
OBJECTIVE: To evaluate the viscoelastic properties of two experimental BPA-free and one BisGMA-based orthodontic resin composite adhesives for bonding fixed retainers. METHODS: A commercially available BisGMA-based (TXA: Transbond LR) and two bisphenol A-free experimental adhesives (EXA and EXB) were included in the study. The viscoelastic behavior of the adhesives was evaluated under static and dynamic conditions at dry and wet states and at various temperatures (21, 37, 50°C)...
October 18, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Virginia Moreno, Eulogio J Llorent-Martínez, Mohammed Zougagh, Angel Ríos
A supercritical carbon dioxide medium was used for the decoration of functionalized multi-walled carbon nanotubes (MWCNTs) with metallic nanoparticles. This procedure allowed the rapid and simple decoration of carbon nanotubes with the selected metallic nanoparticles. The prepared nanomaterials were used to modify screen-printed electrodes, improving their electrochemical properties and allowing to obtain a wide range of working electrodes based on carbon nanotubes. These electrodes were applied to the amperometric determination of vitamin B6 in food and pharmaceutical samples as an example of the analytical potentiality of the electrodes thus prepared...
December 1, 2016: Talanta
You-Na Lee, Koichi Okumura, Tatsuya Iwata, Kazuhiro Takahashi, Toshiaki Hattori, Makoto Ishida, Kazuaki Sawada
A bio-image sensor using a patterned apyrase-immobilized membrane was developed to visualize the activities of adenosine triphosphate (ATP) and H(+) ion in real-time. An enzymatic membrane patterning technique was suggested to immobilize apyrase on a specific sensing area of a charge coupled device (CCD)-type image sensor. It was able to observe the spatiotemporal information of ATP and H(+) ion. The smallest size of a patterned membrane is 250×250µm(2). The fabrication parameters of the patterned membrane, such as its thickness and the intensity of the incident light used for photolithography, were optimized experimentally...
December 1, 2016: Talanta
Qinqin Wang, Lu Wang, Kai Sheng, Lina Zou, Gaiping Li, Baoxian Ye
In this paper, a simple, low cost, highly sensitive voltammetric method for determination of tetrahydropalmatine was described, which was based on a new electrochemical sensor, poly (L-glutamic acid) functionalized electrochemical reduction graphene oxide modified glassy carbon electrode. The electrochemical behavior of tetrahydropalmatine was investigated in detail and some dynamic parameters of electrode process were calculated for the first time. Due to large surface area and good conductivity of proposed sensor, a wider linear range (3...
December 1, 2016: Talanta
Alexander Romagna, Marcus Unterrainer, Christine Schmid-Tannwald, Matthias Brendel, Jörg-Christian Tonn, Silke Birgit Nachbichler, Alexander Muacevic, Peter Bartenstein, Friedrich-Wilhelm Kreth, Nathalie Lisa Albert
BACKGROUND: After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness of dynamic O-(2-(18)F-Fluoroethyl)-L-Tyrosine positron emission tomography ((18)F-FET PET) in patients with MRI-based suspicion of tumor recurrence after focused high dose radiotherapy of brain metastases. METHODS: Twenty-two patients with 34 brain metastases (median age 61...
October 21, 2016: Radiation Oncology
R Boni, A Gallo, S Cecchini
Owing to the progressive decline of sperm motility during storage there is a need to find substances capable of enhancing sperm energy metabolism and motility and/or preserving it from oxidative damage. The aim of this study was to evaluate in frozen/thawed bovine spermatozoa the effect of several compounds, such as myo-inositol, pentoxifylline, penicillamine + hypotaurine + epinephrine mixture (PHE), caffeine and coenzyme Q10+ zinc + d-aspartate mixture (CZA), on either kinetic or metabolic parameters. Sperm kinetics was evaluated by Sperm Class Analyser whereas specific fluorochromes were used to evaluated mitochondrial membrane potential (MMP), intracellular pH, intracellular calcium concentration and lipid peroxidation...
October 21, 2016: Andrology
S Chiangga, W Pornkaveerat, T D Frank
Three studies were considered in which jasmonate-isoleucine levels were observed for several hours after plant wounding. The data from these studies were fitted to a first order kinetical model describing jasmonate-isoleucine complex formation and dissociation. It was found that the model could explain up to 97 percent of the variations in the data sets. In general, the data re-analysis confirmed that the protein-protein interactions involved in the biosynthesis and dissociation of the jasmonate-isoleucine complex are fast relative to the dynamics of the jasmonate levels themselves...
September 23, 2016: Journal of Plant Physiology
Levente Rózsa, András Deák, Eszter Simon, Rocio Yanes, László Udvardi, László Szunyogh, Ulrich Nowak
We determined the parameters of a classical spin Hamiltonian describing an Fe monolayer on Pd(111) surface with a Pt_{1-x}Ir_{x} alloy overlayer from ab initio calculations. While the ground state of the system is ferromagnetic for x=0.00, it becomes a spin spiral state as Ir is intermixed into the overlayer. Although the Dzyaloshinsky-Moriya interaction is present in the system, we will demonstrate that the frustrated isotropic exchange interactions play a prominent role in creating the spin spiral state, and these frustrated couplings lead to an attractive interaction between Skyrmions at short distances...
October 7, 2016: Physical Review Letters
James K Utterback, Amanda N Grennell, Molly B Wilker, Orion M Pearce, Joel D Eaves, Gordana Dukovic
In CdS nanocrystals, photoexcited holes rapidly become trapped at the particle surface. The dynamics of these trapped holes have profound consequences for the photophysics and photochemistry of these materials. Using a combination of transient absorption spectroscopy and theoretical modelling, we demonstrate that trapped holes in CdS nanorods are mobile and execute a random walk at room temperature. In CdS nanorods of non-uniform width, we observe the recombination of spatially separated electrons and trapped holes, which exhibits a t(-1/2) power-law decay at long times...
November 2016: Nature Chemistry
Anwar Madkhali, Michael Chernos, Dana Grecov, Ezra Kwok
BACKGROUND: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE: The purpose of this study is to investigate the effects of protein content on synovial fluid shear rheology. A secondary study outcome will include study of the temperature dependence of synovial fluid behaviour...
October 19, 2016: Biorheology
Mangesh I Chaudhari, Jijeesh R Nair, Lawrence R Pratt, Fernando A Soto, Perla B Balbuena, Susan Rempe
Lithium ion solvation and diffusion properties in ethylene carbonate (EC) and propylene carbonate (PC) are studied by molecular simulation, experiments, and electronic structure calculations. Studies carried out in water provide a reference for interpretation. Classical molecular dynamics simulation results are compared to ab initio molecular dynamics to as- sess non-polarizable force field parameters for solvation structure of the carbonate solvents. Quasi-chemical theory (QCT) is adapted to take advantage of four-fold occupancy of the near-neighbor solvation structure observed in simulations, and used to calculate solvation free energies...
October 21, 2016: Journal of Chemical Theory and Computation
Petr Stadlbauer, Liuba Mazzanti, Tristan Cragnolini, David J Wales, Philippe Derreumaux, Samuela Pasquali, Jiri Sponer
G-quadruplexes are the most important non-canonical DNA architectures. Many quadruplex-forming sequences, including the human telomeric sequence d(GGGTTA)n, have been investigated due to their implications in cancer and other diseases, and because of their potential in DNA-based nanotechnology. Despite availability of atomistic structural studies of folded G-quadruplexes, their folding pathways remain mysterious, and mutually contradicting models of folding coexist in the literature. Recent experiments convincingly demonstrated that G-quadruplex folding often takes days to reach the thermodynamics equilibrium...
October 21, 2016: Journal of Chemical Theory and Computation
Jia Min Lee, Wai Yee Yeong
Bioprinting is an emerging technology that allows the assembling of both living and non-living biological materials into an ideal complex layout for further tissue maturation. Bioprinting aims to produce engineered tissue or organ in a mechanized, organized, and optimized manner. Various biomaterials and techniques have been utilized to bioprint biological constructs in different shapes, sizes and resolutions. There is a need to systematically discuss and analyze the reported strategies employed to fabricate these constructs...
October 21, 2016: Advanced Healthcare Materials
Kristian Jensen, Rikke Krusenstjerna-Hafstrøm, Jesper Lohse, Kenneth H Petersen, Helene Derand
In clinical routine pathology today, detection of protein in intact formalin-fixed, paraffin-embedded tissue is limited to immunohistochemistry, which is semi-quantitative. This study presents a new and reliable quantitative immunohistochemistry method, qIHC, based on a novel amplification system that enables quantification of protein directly in formalin-fixed, paraffin-embedded tissue by counting of dots. The qIHC technology can be combined with standard immunohistochemistry, and assessed using standard bright-field microscopy or image analysis...
October 21, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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