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https://www.readbyqxmd.com/read/29783243/-electromyographic-characteristics-of-temporal-and-masticatory-muscles-in-patients-with-compression-dislocation-dysfunction-of-temporomandibular-joints-of-different-severity
#1
Pavlo I Yatsenko, Oleg V Rybalov, Oleg I Yatsenko, Vadym M Novikov, Dmytro M Kоrol, Dmytro D Kindiy, Victor D Kindiy
OBJECTIVE: Introduction: The main causes of dysfunctional conditions of the temporomandibular joints (TMJ), are occlusal, neurogenic, orthodontic disorders. The muscular component of TMJ is determines the dynamic anatomical and functional state of the mandible Therefore, in the diagnosis of dysfunctions and understanding of their pathogenesis belongs to the electromyographic method of investigation. The aim of the work was a comparative assessment of the bioelectrical activity of the actual chewing and temporal muscles in patients with musculo-articular compressiondislocation dysfunction of the TMJ of various severity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783117/changes-in-soil-nitrogen-dynamics-caused-by-prescribed-fires-in-dense-gorse-lands-in-sw-pyrenees
#2
Leire Múgica, Rosa M Canals, Leticia San Emeterio
Rural depopulation, abandonment of traditional land uses and decrease of extensive stockfarming is accelerating shrub encroachment in mountain areas. In NW Spain, gorse (Ulex gallii Planch.) is expanding, developing dense shrublands that accumulate high fuel-loads, ignite easily and persist during long periods as alternate stable states. Under this scenario, traditional bush-to-bush farming fires are being replaced by high fuel-load burnings performed by specialised teams to reduce fuels and promote mosaic landscapes...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29783099/leveraging-the-cruzain-s3-subsite-to-increase-affinity-for-reversible-covalent-inhibitors
#3
Lorenzo Cianni, Geraldo Sartori, Fabiana Rosini, Daniela De Vita, Gabriel Pires, Bianca Rebelo Lopes, Andrei Leitão, Antonio C B Burtoloso, Carlos A Montanari
Cruzain is the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease. Reversible covalent cruzain inhibitors can block the steps of cell differentiation in the parasite and kill the organism. To this end, the description of how inhibitors modified at the P2/P3 positions lead to analogs with greater cruzain affinity to the S2/S3 subsites is of fundamental importance. Albeit many efforts are being employed in the characterization of the interaction processes with S2 subsite, little is known about the cruzain S3 subsite...
April 26, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29782993/generalized-recurrent-neural-network-accommodating-dynamic-causal-modeling-for-functional-mri-analysis
#4
Yuan Wang, Yao Wang, Yvonne W Lui
Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29782927/modeling-the-odor-landscape-resulting-from-the-pumping-behavior-of-bivalve-clams-in-the-presence-of-predators
#5
A Alvarez
Motivated by experimental findings, a computational fluid dynamics (CFD) model was used to investigate whether the clam Mercenaria mercenaria may alter its cue downstream variability by an exhalant random pumping behavior. This behavior was hypothesized to occur in the presence of predator chemical signals in order to prevent successful tracking by the predator. Simulated downstream flow and mixing conditions derived from the random nature of the clam exhalant jet in a crossflow were analyzed by computing an intermittency factor, determining the field of finite-time Lyapunov exponents (FTLEs) and identifying the resulting Lagrangian coherent structures (LCSs)...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782805/maintaining-supersaturation-of-nimodipine-by-pvp-with-or-without-the-presence-of-sodium-lauryl-sulfate-and-sodium-taurocholate
#6
Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery system to improve the dissolution rate and oral bioavailability of poorly water soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 years, yet the mechanism by which PVP maintains the supersaturation and subsequently improves the bioavailability of NMD was rarely investigated. In this research, we first studied the molecular interactions between NMD and PVP by solution NMR using CDCl3 as the solvent, and drug-polymer Flory-Huggins interaction parameter...
May 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29782540/monte-carlo-simulations-of-microtubule-arrays-the-critical-roles-of-rescue-transitions-the-cell-boundary-and-tubulin-concentration-in-shaping-microtubule-distributions
#7
Lynne Cassimeris, Jessica C Leung, David J Odde
Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have been well characterized, we lack a convenient way to predict how the measured dynamic parameters shape the entire microtubule system within a cell, or how the system responds when specific parameters change in response to internal or external signals. Here we describe a Monte Carlo model to simulate an array of dynamic microtubules from parameters including the cell radius, total tubulin concentration, microtubule nucleation rate from the centrosome, and plus end dynamic instability...
2018: PloS One
https://www.readbyqxmd.com/read/29782279/-response-predictors-for-physical-training-hfref-patients
#8
V L Galenko, T A Lelyavina, M Y Sitnikova
PURPOSE: To identify different types and possible predictors of physical rehabilitation (PR) response in reduced ejection fraction heart failure (HFrEF) patients, selected on the basis of achievement the lactate threshold during cardiopulmonary exercising test (CPET). METHODS: 64 patients, chronic heart failure (CHF) NYHA II-III functional class were included in our study. Mean age 54±12,5 years, body mass index (BMI) 26,5±6,4 kg/m2, ejection fraction (EF) 26,4±1,4 %, NYHA II: III (67 %: 33 % patients)...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782250/-effect-of-right-ventricular-myocardial-contractility-on-the-response-to-cardiac-resynchronization-therapy
#9
D I Lebedev, S V Popov, A I Mishkina, M V Lebedeva
AIM: To determine the effect of right ventricular myocardial contractility on the response to cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 80 patients (49 men, mean age 54±10.5) diagnosed with dilated cardiomyopathy, complete left bundle branch block, and the QRS complex width 146 to 240 ms (183±32 ms). Heart failure was NYHA FC III, ejection fraction (EF) - 30.1±3.8 %, 6‑min walk test - 290.5±64.3 m, and end-diastolic volume (EDV) - 220...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782172/assembly-dynamics-of-plasmonic-dna-capped-gold-nanoparticle-monolayers
#10
Thomas L Derrien, Michelle Zhang, Patrick Dorion, Detlef-M Smilgies, Dan Luo
The self-assembly of nanoparticles in aqueous solutions promises wide applications but requires the careful balance of many parameters not present in organic solvents. While the presence of long-range electrostatic interactions in aqueous solutions may complicate such assemblies, they provide additional parameters through which to control self-assembly. Here, with DNA-capped gold nanoparticles and through variation of the ionic strength in aqueous solutions, we explored the influence of electrostatic interactions on the adsorption of negatively charged nanoparticles on a positively charged surface...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781740/predicting-the-impact-of-pneumococcal-conjugate-vaccine-programme-options-in-vietnam
#11
Olivier Le Polain de Waroux, W John Edmunds, Kensuke Takahashi, Koya Ariyoshi, E Kim Mulholland, David Goldblatt, Yoon Hong Choi, Dang Duc Anh, Lay Myint Yoshida, Stefan Flasche
Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietnam - a country that has not yet introduced PCV - through a dynamic transmission model. We modelled the impact on carriage and invasive pneumococcal disease (IPD) of routine vaccination (RV) only and that of RV with CCs targeting <1y olds (CC1), <2y olds (CC2) and <5y olds (CC5)...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29781389/tracking-neuronal-connectivity-from-electric-brain-signals-to-predict-performance
#12
Fabrizio Vecchio, Francesca Miraglia, Paolo Maria Rossini
The human brain is a complex container of interconnected networks. Network neuroscience is a recent venture aiming to explore the connection matrix built from the human brain or human "Connectome." Network-based algorithms provide parameters that define global organization of the brain; when they are applied to electroencephalographic (EEG) signals network, configuration and excitability can be monitored in millisecond time frames, providing remarkable information on their instantaneous efficacy also for a given task's performance via online evaluation of the underlying instantaneous networks before, during, and after the task...
May 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29781379/innovative-curriculum-integrating-the-bio-behavioral-and-social-science-principles-across-the-lifestages-in-basic-science-years
#13
Anuradha Lele Mookerjee, Bradford D Fischer, Susan Cavanaugh, Vijay Rajput
Behavioral and social science integration in clinical practice improves health outcomes across the life stages. The medical school curriculum requires an integration of the behavioral and social science principles in early medical education. We developed and delivered a four-week course entitled "LifeStages" to the first year medical students. The learning objectives of the bio-behavioral and social science principles along with the cultural, economic, political, and ethical parameters were integrated across the lifespan in the curriculum matrix...
May 20, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29781342/dw-mri-and-dce-mri-are-of-complementary-value-in-predicting-pathologic-response-to-neoadjuvant-chemoradiotherapy-for-esophageal-cancer
#14
Sophie E Heethuis, Lucas Goense, Peter S N van Rossum, Alicia S Borggreve, Stella Mook, Francine E M Voncken, Annemarieke Bartels-Rutten, Berthe M P Aleman, Richard van Hillegersberg, Jelle P Ruurda, Gert J Meijer, Jan J W Lagendijk, Astrid L H M W van Lier
PURPOSE: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. MATERIAL AND METHODS: Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post)...
May 21, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29781138/comparison-of-the-progressive-resolution-optimizer-and-photon-optimizer-in-vmat-optimization-for-stereotactic-treatments
#15
Han Liu, Benjamin Sintay, Keith Pearman, Qingyang Shang, Lane Hayes, Jacqueline Maurer, Caroline Vanderstraeten, David Wiant
The photon optimization (PO) algorithm was recently released by Varian Medical Systems to improve volumetric modulated arc therapy (VMAT) optimization within Eclipse (Version 13.5). The purpose of this study is to compare the PO algorithm with its predecessor, progressive resolution optimizer (PRO) for lung SBRT and brain SRS treatments. A total of 30 patients were selected retrospectively. Previously, all the plans were generated with the PRO algorithm within Eclipse Version 13.6. In the new version of PO algorithm (Version 15), dynamic conformal arcs (DCA) were first conformed to the target, then VMAT inverse planning was performed to achieve the desired dose distributions...
May 20, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29781059/water-decontamination-containing-nitrate-using-biosorption-with-moringa-oleifera-in-dynamic-mode
#16
Rebecca Manesco Paixão, Isabela Maria Reck, Raquel Guttierres Gomes, Rosângela Bergamasco, Marcelo Fernandes Vieira, Angélica Marquetotti Salcedo Vieira
This study was conducted to assess the feasibility of using Moringa oleifera Lam. (MO) seeds in the biosorption of nitrate present in aqueous solutions by means of batch and fixed-bed column biosorption processes. The batch assays showed that nitrate biosorption is enhanced under experimental conditions of pH 3 and a biosorbent mass of 0.05 g. For the experiments in dynamic mode, the results obtained from the statistical parameters showed that lesser pH, lesser feed flow rate, and higher initial concentration will result in an increase of the maximum capacity of the bed...
May 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29780993/ideal-reversible-polymer-networks
#17
German Alberto Parada, Xuanhe Zhao
In this article we introduce the concept of ideal reversible polymer networks, which have well-controlled polymer network structures similar to ideal covalent polymer networks but exhibit viscoelastic behaviors due to the presence of reversible crosslinks. We first present a theory to describe the mechanical properties of ideal reversible polymer networks. Because short polymer chains of equal length are used to construct the network, there are no chain entanglements and the chains' Rouse relaxation time is much shorter than the reversible crosslinks' characteristic time...
May 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29780839/comparison-of-lower-extremity-recovery-after-anterior-cruciate-ligament-reconstruction-with-transphyseal-hamstring-versus-extraphyseal-iliotibial-band-techniques-in-skeletally-immature-athletes
#18
Dai Sugimoto, Benton E Heyworth, Sara E Collins, Ryan T Fallon, Mininder S Kocher, Lyle J Micheli
Background: The influence of graft type on recovery after anterior cruciate ligament reconstruction (ACLR) has not been adequately studied in pediatric patients. Purpose: To describe lower extremity functional recovery parameters at the 6-month mark after ACLR across 3 distinct groups of skeletally immature patients: pediatric male patients with transphyseal hamstring grafts (PM-HS), pediatric female patients with transphyseal hamstring grafts (PF-HS), and pediatric male patients with extraphyseal iliotibial band grafts (PM-ITB)...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29780562/kinetic-studies-on-strand-displacement-in-de-novo-designed-parallel-heterodimeric-coiled-coils
#19
Mike C Groth, W Mathis Rink, Nils F Meyer, Franziska Thomas
Among the protein folding motifs, which are accessible by de novo design, the parallel heterodimeric coiled coil is most frequently used in bioinspired applications and chemical biology in general. This is due to the straightforward sequence-to-structure relationships, which it has in common with all coiled-coil motifs, and the heterospecificity, which allows control of association. Whereas much focus was laid on designing orthogonal coiled coils, systematic studies on controlling association, for instance by strand displacement, are rare...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780513/simulations-of-the-synthesis-of-boron-nitride-nanostructures-in-a-hot-high-pressure-gas-volume
#20
Predrag S Krstic, Longtao Han, Stephan Irle, Hiromi Nakai
We performed nanosecond timescale computer simulations of clusterization and agglomeration processes of boron nitride (BN) nanostructures in hot, high pressure gas, starting from eleven different atomic and molecular precursor systems containing boron, nitrogen and hydrogen at various temperatures from 1500 to 6000 K. The synthesized BN nanostructures self-assemble in the form of cages, flakes, and tubes as well as amorphous structures. The simulations facilitate the analysis of chemical dynamics and we are able to predict the optimal conditions concerning temperature and chemical precursor composition for controlling the synthesis process in a high temperature gas volume, at high pressure...
April 21, 2018: Chemical Science
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