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https://www.readbyqxmd.com/read/28432812/preparation-characterization-and-in-vivo-study-of-rhein-solid-lipid-nanoparticles-for-oral-delivery
#1
Haiyang Feng, Yuping Zhu, Zhixuan Fu, Dechuan Li
In this study, rhein-SLNs were successfully produced by hot homogenization followed by ultrasonication. Precirol ATO5 in which Rhein exhibited higher partition coefficient was selected for preparation of SLNs. In the dynamic light scattering, the rhein SLNs showed a smaller size with a mean value of 120.8 ± 7.9 nm and with zeta potential of -16.9 ± 2.3 mV. SLNs exhibited a good stability during the period of 2 months. The SLNs indicated faster drug release with a burst release within 2 hours and followed by a sustained release with a biphasic drug release pattern...
April 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28432806/rapid-acceptance-testing-of-modern-linac-using-on-board-mv-and-kv-imaging-systems
#2
Sridhar Yaddanapudi, Bin Cai, Taylor Harry, Steven Dolly, Baozhou Sun, Hua Li, Keith Stinson, Camille Noel, Lakshmi Santanam, Todd Pawlicki, Sasa Mutic, S Murty Goddu
PURPOSE: The purpose of this study was to develop a novel process for using on-board MV and kV Electronic Portal Imaging Devices (EPIDs) to perform linac acceptance testing (AT) for two reasons: 1) to standardize the assessment of new equipment performance, and 2) to reduce the time to clinical use while reducing physicist workload. METHODS AND MATERIALS: In this study, Varian TrueBeam linacs equipped with amorphous silicon based EPID (aS1000) were used. The conventional set of AT tests and tolerances were used as a baseline guide...
April 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28432538/superoxide-generated-in-the-chloroplast-stroma-causes-photoinhibition-of-photosystem-i-in-the-shade-establishing-tree-species-psychotria-henryi
#3
Wei Huang, Ying-Jie Yang, Jiao-Lin Zhang, Hong Hu, Shi-Bao Zhang
Our previous studies indicated that high light induced significant photoinhibition of photosystem I (PSI) in the shade-establishing tree species Psychotria henryi. However, the underlying mechanism has not been fully clarified. In the present study, in order to investigate the mechanism of PSI photoinhibition in P. henryi, we treated detached leaves with constant high light in the presence of methyl viologen (MV) or a soluble α-tocopherol analog, 2,2,5,7,8-pentamethyl-6-chromanol (PMC). We found that MV significantly depressed photochemical quantum yields in PSI and PSII when compared to PMC...
April 21, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28432530/an-integrated-microsystem-with-dielectrophoresis-enrichment-and-impedance-detection-for-detection-of-escherichia-coli
#4
Renjie Wang, Yi Xu, Haitao Liu, Jinlan Peng, Joseph Irudayaraj, Feiyun Cui
An integrated microsystem device with matched interdigitated microelectrode chip was fabricated for enrichment and detection of Escherichia coli O157:H7. The microsystem has integrated with positive dielectrophoresis (pDEP) enrichment and in situ impedance detection, whose total volume is only 3.0 × 10(-3) m(3), and could provide impedance testing voltages of 0 ~ 10 V, detection frequencies of 1 KHz ~ 1 MHz, DEP excitation signals with amplitude of 0 ~ 10 Vpp and frequencies of 1KHz ~ 1 MHz, which fully meets the demands of pDEP enrichment and impedance detection for bacteria...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28432503/high-voltage-zones-within-the-pulmonary-vein-antra-major-determinants-of-acute-pulmonary-vein-reconnections-after-atrial-fibrillation-ablation
#5
Koichi Nagashima, Ichiro Watanabe, Yasuo Okumura, Kazuki Iso, Keiko Takahashi, Ryuta Watanabe, Masaru Arai, Sayaka Kurokawa, Toshiko Nakai, Kimie Ohkubo, Shunichi Yoda, Atsushi Hirayama
PURPOSE: Recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) is mainly due to PV reconnections. Patient-specific tissue characteristics that may contribute remain unidentified. This study aimed to assess the relationship between the bipolar electrogram voltage amplitudes recorded from the PV-left atrial (LA) junction and acute PV reconnection sites. METHODS: Three-dimensional LA voltage maps created before an extensive encircling PVI in 47 AF patients (31 men; mean age 62 ± 11 years) were examined for an association between the EGM voltage amplitude recorded from the PV-LA junction and acute post-PVI PV reconnections (spontaneous PV reconnections and/or ATP-provoked dormant PV conduction)...
April 21, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28432447/twofold-minimum-variance-beamforming-for-enhanced-ultrasound-imaging
#6
Sayed Mahmoud Sakhaei, Seyede Elham Shamsian
PURPOSE: To calculate the optimal weights of a minimum variance (MV) beamformer, the covariance matrix of the received data should be estimated. In ultrasound imaging, it is done through spatial smoothing. However, this technique reduces the effective aperture and consequently limits the attainable resolution. To mitigate this effect, we propose a new configuration for applying an adaptive beamforming method. METHODS: The method is based on applying MV in a twofold configuration such that the outputs of the subarrays are combined through an adaptive MV-like beamformer, instead of simply summing them...
April 21, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28431329/stealth-recombinant-human-serum-albumin-nanoparticles-conjugating-5-fluorouracil-augmented-drug-delivery-and-cytotoxicity-in-human-colon-cancer-ht-29-cells
#7
Ankita Sharma, Amanpreet Kaur, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
BACKGROUND AND OBJECTIVE: 5-Fluorouracil (5-FU) is a first-line chemotherapeutic drug in colorectal cancer. However, intravenous administration of 5-FU at the dose of 7-12mg/kg exhibits curbs like short half-life (20min) and toxic side-effects on bone marrow cells. Therefore, in present investigation, 5-FU was conjugated to poly (ethylene glycol) anchored recombinant human serum albumin nanoparticles (5-FU-rHSA-PEG-NPs) to improve the pharmacokinetic and therapeutic profiles. METHODS AND RESULTS: The mean particle size of 5-FU-rHSA-NPs was measured to be 44...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28430375/electrochemical-water-oxidation-catalyzed-by-an-in-situ-generated-%C3%AE-co-oh-2-film-on-zeolite-y-surface
#8
Samar Kumar Das, Suranjana Bose, Joyashish Debgupta, Rani Ramsundar
The design and synthesis of an efficient and robust water oxidation catalyst (WOC) with inexpensive materials remain an important challenge in the context of 'artificial photosynthesis'. Herein, we report a simple but unique technique to generate in situ a thin-film of α-Co(OH)2 on the surface of zeolite-Y [hereafter named as Y-α-Co(OH)2] that acts as an efficient and stable catalyst for electrochemical water oxidation in an alkaline pH. Catalyst Y-α-Co(OH)2 is so stable that it retains its catalytic activity even after 2000 cyclic voltammetric cycles of water oxidation...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28429831/one-step-fabrication-of-monolithic-electrodes-comprising-co9s8-particles-supported-on-cobalt-foam-for-efficient-and-durable-oxygen-evolution-reaction
#9
Dehua Xiong, Qingqing Zhang, Sitaramanjaneya Mouli Thalluri, Junyuan Xu, Wei Li, Xiuli Fu, Lifeng Liu
We report a very easy and cost-effective approach to the fabrication of monolithic Co9S8 water oxidation electrodes (Co@Co9S8), which is fabricated by one-step hydrothermal treatment of commercially available cobalt foam in the presence of thiourea. The morphology, crystal structure, microstructure, and composition of as-fabricated Co@Co9S8 electrodes are examined using scanning electron microscopy (SEM), powder X-ray diffraction (XRD), transmission electron microscope (TEM), and X-ray photoelectron spectroscopy (XPS), and their electrochemical properties are investigated by cyclic voltammetry (CV), chronopotentiometry (CP), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS)...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28429827/a-descriptive-and-broadly-applicable-model-of-therapeutic-and-stray-absorbed-dose-from-6-mv-to-25-mv-photon-beams
#10
Christopher W Schneider, Wayne D Newhauser, Lydia J Wilson, Uwe Schneider, Robert Kaderka, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk, Marco Durante, Roger M Harrison
PURPOSE: To develop a simple model of therapeutic and stray absorbed dose for a variety of treatment machines and techniques without relying on proprietary machine-specific parameters. METHODS: Dosimetry measurements conducted in this study and from the literature were used to develop an analytical model of absorbed dose from a variety of treatment machines and techniques in the 6 MV to 25 MV interval. A modified one-dimensional gamma-index analysis was performed to evaluate dosimetric accuracy of the model on an independent dataset consisting of measured dose profiles from seven treatment units spanning four manufacturers...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429810/cisplatin-directed-coordination-crosslinking-nanogels-with-thermo-ph-sensitive-triblock-polymers-improvement-on-chemotherapic-efficacy-via-sustained-release-and-drug-retention
#11
Hao Zhao, Jiabao Xu, Jiangshan Wan, Shinan Geng, Han Li, Xiaole Peng, Qianwen Fu, Ming He, Yanbing Zhao, Xiangliang Yang
To realize the sustained release and long-term intratumoural retention of water-soluble cisplatin, thermo/pH-sensitive cisplatin-directed coordination-crosslinking nanogels (Pt-PNA) were developed via the coordination bonds of Pt-carboxyl groups. As the coordination ratio (CR) of the Pt-carboxyl bonds increased from 5% to 35%, the sizes of the Pt-PNA nanogels decreased from 999 nm to 167 nm, and their zeta potentials increased from -35 mV to -13 mV. Only through a simple mixing of cisplatin and PNAs, the entrapment efficiencies (EEs) of the Pt-PNA nanogels reached near 100% (>90%), and the drug-loading amounts (DLs) of cisplatin could achieve up to 25...
April 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28429628/relationship-of-steroid-dosing-and-duration-of-mechanical-ventilation-in-adult-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#12
Jennifer McCann, Katherine Teare, Emily Cochard, Brent Toney
BACKGROUND: The optimal steroid dose for patients who require mechanical ventilation (MV) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is unknown. OBJECTIVE: The primary objective of the study is to describe the relationship between steroid doses prescribed and duration of MV. METHODS: This was a retrospective study of patients admitted between October 2013 and September 2014 who were prescribed steroids and received MV for ≥48 hours for AECOPD...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28429537/preliminary-findings-on-the-safety-of-1-5-and-3-tesla-magnetic-resonance-imaging-in-cardiac-pacemaker-patients
#13
V F van Dijk, P P H M Delnoy, J J J Smit, R A Ramdat Misier, A Elvan, H W van Es, B J W M Rensing, G Raciti, L V A Boersma
INTRODUCTION: Modern pacemakers are designed to allow patients to undergo Magnetic Resonance Imaging(MRI) under a set of specific conditions. Aim of this study is to provide confirmatory evidence of safety and performance of a new pacing system (ImageReady™, Boston Scientific) in patients undergoing 1.5 and 3 Tesla(T) MRI. METHODS AND RESULTS: Two prospective, non-randomized, single-arm studies were designed to provide confirmatory data of no impact of MRI on device function, lead parameters and patient conditions in subjects implanted with the system undergoing a clinically non-indicated 1...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28429460/automated-t-wave-analysis-can-differentiate-acquired-qt-prolongation-from-congenital-long-qt-syndrome
#14
Alan Sugrue, Peter A Noseworthy, Vaclav Kremen, J Martijn Bos, Bo Qiang, Ram K Rohatgi, Yehu Sapir, Zachi I Attia, Peter Brady, Pedro J Caraballo, Samuel J Asirvatham, Paul A Friedman, Michael J Ackerman
BACKGROUND: Prolongation of the QT on the surface electrocardiogram can be due to either genetic or acquired causes. Distinguishing congenital long QT syndrome (LQTS) from acquired QT prolongation has important prognostic and management implications. We aimed to investigate if quantitative T-wave analysis could provide a tool for the physician to differentiate between congenital and acquired QT prolongation. METHODS: Patients were identified through an institution-wide computer-based QT screening system which alerts the physician if the QTc ≥ 500 ms...
April 21, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28429294/ocular-cubosome-drug-delivery-system-for-timolol-maleate-preparation-characterization-cytotoxicity-ex-vivo-and-in-vivo-evaluation
#15
Jiayuan Huang, Tingting Peng, Yanrong Li, Zhengwen Zhan, Youmei Zeng, Ying Huang, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Glaucoma is an ocular disease featuring increased intraocular pressure (IOP) and its primary treatment strategy is to lower IOP by medication. Current ocular drug delivery in treating glaucoma is confronting a variety of challenges, such as low corneal permeability and bioavailability due to the unique anatomical structure of the human eye. To tackle these challenges, a cubosome drug delivery system for glaucoma treatment was constructed for timolol maleate (TM) in this study. The TM cubosomes (liquid crystalline nanoparticles) were prepared using glycerol monooleate and poloxamer 407 via high-pressure homogenization...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#16
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28428759/morphological-regeneration-and-functional-recovery-of-neuromuscular-junctions-after-tourniquet-induced-injuries-in-mouse-hindlimb
#17
Huiyin Tu, Dongze Zhang, Ryan M Corrick, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Tourniquet application and its subsequent release cause serious injuries to the skeletal muscle, nerve, and neuromuscular junction (NMJ) due to mechanical compression and ischemia-reperfusion (IR). Monitoring structural and functional repair of the NMJ, nerve, and skeletal muscle after tourniquet-induced injuries is beneficial in exploring potential cellular and molecular mechanisms responsible for tourniquet-induced injuries, and for establishing effective therapeutic interventions. Here, we observed long-term morphological and functional changes of the NMJ in a murine model of tourniquet-induced hindlimb injuries...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28428700/preparation-characterization-and-cytotoxic-effects-of-pegylated-nanoliposomal-containing-carboplatin-on-ovarian-cancer-cell-lines
#18
Meysam Ebrahimifar, Amir Nili-Ahmadabadi, Azim Akbarzadeh, Hasan Ebrahimi Shahemabadi, Majid Hasanzadegan, Hemen Moradi-Sardareh, Hassan Madadizadeh, Jalal Rezaee-Diyan
Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin using pegylated liposomal nanocarriers. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428474/evaluation-of-absorbed-dose-for-cbct-in-image-guided-radiation-therapy-comparison-of-each-devices-and-facilities
#19
Yumiko Kitazato, Noriyuki Kuga, Katsutoshi Shirieda, Masahiro Enzaki, Yuji Nakaguchi, Yoshinobu Shimohigashi, Toshihisa Kawasaki, Masahiko Toyoda, Daisuke Kawahara, Fujio Araki, Shinji Kawamura
Recently, intensity-modulated radiation therapy (IMRT) is used worldwide, highly accurate verification of the location using image-guided radiation therapy (IGRT) has become critical. However, the use of cone-beam computed tomography (CBCT) to ascertain the location each time raises concerns about its influence on radiotherapy dosage and increased radiation exposure. The purpose of this study was to measure the absorbed dose using nine kilovoltage (kV) devices and two megavoltage (MV) devices (total 11 devices) at eight facilities, compare the absorbed dose among the devices, and assess the characteristics of the respective devices to ensure optimal clinical operation...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28428249/crystal-structure-and-redox-properties-of-a-novel-cyanobacterial-heme-protein-with-a-his-cys-heme-axial-ligation-and-a-per-arnt-sim-pas-like-domain
#20
Taiki Motomura, Michihiro Suga, Rainer Hienerwadel, Akiko Nakagawa, Thanh-Lan Lai, Wolfgang Nitschke, Takahiro Kuma, Miwa Sugiura, Alain Boussac, Jain-Ren Shen
Photosystem II (PSII) catalyzes the light-induced water oxidation leading to the generation of dioxygen indispensable for sustaining aerobic life on Earth. The PSII reaction center is composed of D1 and D2 proteins encoded by the psbA and psbD genes, respectively. In cyanobacteria, different psbA genes are present in the genome. The thermophilic cyanobacterium Thermosynechococcus elongatus contains 3 psbA genes, psbA1, psbA2 and psbA3 and a new c-type heme protein, Tll0287, was found to be expressed in a strain expressing the psbA2 gene only, but the structure and function of Tll0287 are unknown...
April 20, 2017: Journal of Biological Chemistry
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