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https://www.readbyqxmd.com/read/28110488/examining-mortality-and-rejection-in-combined-heart-lung-transplantations
#1
Sagar Kadakia, Sharven Taghavi, Senthil Jayarajan, Vishnu Ambur, Grayson Wheatley, Larry Kaiser, Yoshiya Toyoda
Background There is a paucity of data on outcomes related to combined heart-lung transplantations (HLTs). Our objective was to identify variables associated with mortality and rejection in HLT. Methods The United Network for Organ Sharing database was reviewed for HLT performed between 1993 and 2008. Long-term survivors (survival > 5 years) were compared with short-term survivors (survival < 5 years). Factors associated with rejection were examined. Risk-adjusted multivariable Cox's proportional hazards regression analysis was performed to examine variables associated with mortality and rejection...
January 22, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28108649/intracellular-oxygen-tension-limits-muscle-contraction-induced-change-in-muscle-oxygen-consumption-under-hypoxic-conditions-during-hb-free-perfusion
#2
Hisashi Takakura, Minoru Ojino, Thomas Jue, Tatsuya Yamada, Yasuro Furuichi, Takeshi Hashimoto, Satoshi Iwase, Kazumi Masuda
Under acute hypoxic conditions, the muscle oxygen uptake (mV˙O2) during exercise is reduced by the restriction in oxygen-supplied volume to the mitochondria within the peripheral tissue. This suggests the existence of a factor restricting the mV˙O2 under hypoxic conditions at the peripheral tissue level. Therefore, this study set out to test the hypothesis that the restriction in mV˙O2 is regulated by the net decrease in intracellular oxygen tension equilibrated with myoglobin oxygen saturation (∆PmbO2) during muscle contraction under hypoxic conditions...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28107455/staged-versus-one-time-complete-revascularization-with-percutaneous-coronary-intervention-in-stemi-patients-with-multivessel-disease-a-systematic-review-and-meta-analysis
#3
Zhenwei Li, Yijiang Zhou, Qingqing Xu, Xiaomin Chen
INTRODUCTION: In patients with acute ST-elevation myocardial infarction (STEMI), the preferred intervention is percutaneous coronary intervention (PCI).Whether staged PCI (S-PCI) or one-time complete PCI (MV-PCI) is more beneficial and safer in terms of treating the non-culprit vessel during the primary PCI procedure is unclear. We performed a meta-analysis of all randomized and non-randomized controlled trials comparing S-PCI with MV-PCI in patients with acute STEMI and MVD. METHODS: Studies of STEMI with multivessel disease receiving primary PCI were searched in PUBMED, EMBASE and The Cochrane Register of Controlled Trials from January 2004 to December 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28107074/analysis-of-the-normal-electrocardiogram-in-wild-rooks-corvus-frugilegus
#4
Hossein Hassanpour, Hossein Abbasi Dehkordi, Mehdi Khosravi, Saeid Soltani, Leila Nasiri
To describe the normal electrocardiographic (ECG) patterns and values in unanesthetized rooks ( Corvus frugilegus ), standard bipolar (I, II, and III) and augmented unipolar limb (aVR, aVL, and aVF) lead ECGs were recorded from 10 clinically healthy wild rooks. Wave forms were analyzed in all leads at 50 mm/s and at 10 mm = 1 mV to determine PR, QRS, ST, and QT durations; the net QRS complex; and P and T amplitudes. The polarity of each waveform was tabulated in all leads. The mean electrical axis (MEA) for the frontal plane was counted by using leads II and III...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28106126/bi-axial-grown-amorphous-mosx-bridged-with-oxygen-on-r-go-as-a-superior-stable-and-efficient-nonprecious-catalyst-for-hydrogen-evolution
#5
Cheol-Ho Lee, Jin-Mun Yun, Sungho Lee, Seong Mu Jo, KwangSup Eom, Doh C Lee, Han-Ik Joh, Thomas F Fuller
Amorphous molybdenum sulfide (MoSx) is covalently anchored to reduced graphene oxide (r-GO) via a simple one-pot reaction, thereby inducing the reduction of GO and simultaneous doping of heteroatoms on the GO. The oxygen atoms form a bridged between MoSx and GO and play a crucial role in the fine dispersion of the MoSx particles, control of planar MoSx growth, and increase of exposed active sulfur sites. This bridging leads to highly efficient (-157 mV overpotential and 41 mV/decade Tafel slope) and stable (95% versus initial activity after 1000 cycles) electrocatalyst for hydrogen evolution...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105952/movement-visualisation-in-virtual-reality-rehabilitation-of-the-lower-limb-a-systematic-review
#6
REVIEW
Luara Ferreira Dos Santos, Oliver Christ, Kedar Mate, Henning Schmidt, Jörg Krüger, Christian Dohle
BACKGROUND: Virtual reality (VR) based applications play an increasing role in motor rehabilitation. They provide an interactive and individualized environment in addition to increased motivation during motor tasks as well as facilitating motor learning through multimodal sensory information. Several previous studies have shown positive effect of VR-based treatments for lower extremity motor rehabilitation in neurological conditions, but the characteristics of these VR applications have not been systematically investigated...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105408/predictors-of-prolonged-mechanical-ventilation-in-pediatric-patients-after-cardiac-surgery-for-congenital-heart-disease
#7
Avisa Tabib, Seyed Ehsan Abrishami, Mohammad Mahdavi, Hojjat Mortezaeian, Ziae Totonchi
BACKGROUND: The duration of mechanical ventilation (MV) is one of the most important clinical factors which predict outcomes in pediatric cardiac surgery. The prolonged mechanical ventilation (PMV) following cardiac surgery is a multifactorial phenomenon and there are conflicts regarding its predictors in pediatric population between different centers. OBJECTIVES: The current study aimed to describe PMV predictors in patients undergoing cardiac surgery for congenital heart disease in a tertiary center for pediatric cardiovascular diseases in Iran...
August 2016: Research in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28104904/-prediction-of-severe-course-in-infants-with-rsv-bronchiolitis-under-6-months-spain
#8
José Miguel Ramos-Fernández, David Moreno-Pérez, Mario Gutiérrez-Bedmar, Alexandra Hernández-Yuste, Ana María Cordón-Martínez, Guillermo Milano-Manso, Antonio Urda-Cardona
OBJECTIVE: The need for mechanical ventilation (MV) in acute bronchiolitis (AB) by respiratory syncytial virus (RSV) varies depending on the series (6-18%). Our goal is to determine the admissions to PICU for MV in patients under 6 months with AB and define the risk factors for building a prediction model. METHODS: Retrospective study of patients younger than 6 months admitted by BA-VRS between the periods April 1, 2010 and March 31, 2015 was made. The primary variable was the admission to PICU for MV...
January 19, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28103017/co2-electroreduction-at-low-overpotential-on-oxide-derived-cu-carbons-fabricated-from-metal-organic-framework
#9
Kun Zhao, Yanming Liu, Xie Quan, Shuo Chen, Hongtao Yu
Electrochemical reduction of CO2 to chemical feedstocks is an attractive solution to prevent CO2 accumulation in atmosphere, but it remains a great challenge to develop the cost-effective catalysts. Herein, we synthesized oxide-derived Cu/carbon (OD Cu/C) catalysts by a facile carbonization of Cu-based MOF (HKUST-1). The resulting materials exhibited highly selective CO2 reduction to alcohol compounds with the total faradic efficiency of 45.2~71.2 % at -0.1 to -0.7 V vs RHE. High-yield methanol and ethanol has been achieved on OD Cu/C-1000 with the production rates of 5...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102946/a-portal-dosimetry-dose-prediction-method-based-on-collapsed-cone-algorithm-using-the-clinical-beam-model
#10
J Martínez Ortega, N Gómez González, P Castro Tejero, M Pinto Monedero, N B Tolani, L Núñez Martín, R Sánchez Montero
PURPOSE: Amorphous silicon electronical portal imaging devices (EPIDs) are widely used for dosimetric measurements in Radiation Therapy. The purpose of this work was to determine if a portal dose prediction method can be utilized for dose map calculations based on the linear accelerator model within a commercial treatment planning system (Pinnacle(3) v8.0 m). METHODS: The method was developed for a 6 MV photon beam on the Varian Clinac 21-EX, at a nominal dose rate of 400 MU/min...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102566/annual-research-review-understudied-populations-within-the-autism-spectrum-current-trends-and-future-directions-in-neuroimaging-research
#11
REVIEW
Allison Jack, Kevin A Pelphrey
BACKGROUND: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD + ID), autism with a history of developmental regression (ASD + R), and minimally verbal autism (ASD + MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes...
January 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28102391/enhancement-in-catalytic-proton-reduction-by-an-internal-base-in-a-diiron-pentacarbonyl-complex-its-synthesis-characterisation-inter-conversion-and-electrochemical-investigation
#12
Zhimei Li, Zhiyin Xiao, Fenfen Xu, Xianghua Zeng, Xiaoming Liu
The reaction of a tripodal ligand (H2L) with a {S2N} donor-set with tri-iron dodecacarbonyl in toluene leads to the isolation of a diiron pentacarbonyl complex 1 as a model for the sub-site of the [FeFe]-hydrogenase. Protonation of this complex under CO (1 atm.) forms quantitatively the hexacarbonyl complex 2H+ with a pendant pyridinium group. Infrared spectroscopic investigations indicate that its pendant pyridinium group dissociates to give hexacarbonyl complex 2 which forms subsequently the pentacarbonyl complex 1...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28101949/highly-active-three-dimensional-nife-cu2o-nanowires-cu-foam-electrode-for-water-oxidation
#13
Yan Gao, Hu Chen, Licheng Sun
Water splitting is of paramount importance for exploiting renewable energy conversion and storage systems, but is greatly hindered by the kinetically sluggish oxygen evolution reaction. Here, we develop a three-dimensional, greatly efficient and durable NiFe/Cu2O nanowires/Cu foam anode (NiFe/Cu2O NWs/CF) for water oxidation in 1.0 M KOH. The obtained electrode exhibited a current density of 10 mA/cm2 at a uniquely low overpotential of 215 mV and can keep a steady current density of 100 mA/cm2 for 50 h at an overpotential of 260 mV...
January 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28101839/surgical-treatment-of-ischemic-mitral-regurgitation-valve-repair-versus-replacement
#14
REVIEW
Abhishek Sharma, Sahil Agrawal, Sunny Goel, Jeffrey S Borer
PURPOSE OF REVIEW: Ischemic mitral regurgitation (MR), which occurs in about 20-30% patients with a prior myocardial infarction, is associated with worsening heart failure and an increase in cardiovascular mortality. It should be treated surgically if certain hemodynamic severity criteria are met and in patients who continue to experience symptoms of heart failure despite optimal medical therapy. However, current guidelines do not suggest which of the available approaches to mitral valve surgery-mitral valve (MV) repair or replacement (MVR) is superior for this indication...
January 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28101458/cationic-liposomes-modified-with-polyallylamine-as-a-gene-carrier-preparation-characterization-and-transfection-efficiency-evaluation
#15
Reza Kazemi Oskuee, Asma Mahmoudi, Leila Gholami, Alireza Rahmatkhah, Bizhan Malaekeh-Nikouei
Purpose: Cationic polymers and cationic liposomes have shown to be effective non-viral gene delivery vectors. In this study, we tried to improve the transfection efficiency by employing the advantages of both. Methods: For this purpose, modified polyallylamines (PAAs) were synthesized. These modifications were done through the reaction of PAA (15 KDa) with acrylate and 6-bromoalkanoic acid derivatives. Liposomes comprising of these cationic polymers and cationic lipid were prepared and extruded through polycarbonate filters to obtain desired size...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100723/a-respiratory-gated-micro-ct-comparison-of-respiratory-patterns-in-free-breathing-and-mechanically-ventilated-rats
#16
Nancy L Ford, Lynda McCaig, Andrew Jeklin, James F Lewis, Ruud A W Veldhuizen, David W Holdsworth, Maria Drangova
In this study, we aim to quantify the differences in lung metrics measured in free-breathing and mechanically ventilated rodents using respiratory-gated micro-computed tomography. Healthy male Sprague-Dawley rats were anesthetized with ketamine/xylazine and scanned with a retrospective respiratory gating protocol on a GE Locus Ultra micro-CT scanner. Each animal was scanned while free-breathing, then intubated and mechanically ventilated (MV) and rescanned with a standard ventilation protocol (56 bpm, 8 mL/kg and PEEP of 5 cm H2O) and again with a ventilation protocol that approximates the free-breathing parameters (88 bpm, 2...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#17
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28100478/adropin-acts-in-the-rat-paraventricular-nucleus-to-influence-neuronal-excitability
#18
Spencer P Loewen, Alastair V Ferguson
Adropin is a peptide hormone with cardiovascular and metabolic roles in the periphery, including effects on glucose and lipid homeostasis. Central administration of adropin has been shown to inhibit water intake in rats, however, the site at which central adropin acts has yet to be elucidated. The hypothalamic paraventricular nucleus (PVN), a critical autonomic control center, plays essential roles in the control of fluid balance, energy homeostasis and cardiovascular regulation, and is therefore a potential target for centrally acting adropin...
January 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28099799/hierarchically-porous-electrocatalyst-with-vertically-aligned-defect-rich-comos-nanosheets-for-her-in-alkaline-medium
#19
Zexing Wu, Junpo Guo, Jie Wang, Rong Liu, Weiping Xiao, Cuijuan Xuan, Kedong Xia, Deli Wang
Effective electrocatalysts for hydrogen evolution reaction (HER) in alkaline electrolytes can be developed via a simple solvothermal process. In this work, firstly, the prepared CoMoS nanomaterials through solvothermal treatment have a porous, defect-rich, and vertically aligned nanostructure, which is beneficial for HER in an alkaline medium. Secondly, the electron transfer from Co to MoS2 that reduces the unoccupied d-orbitals of Mo, can also enhance the HER kinetics in an alkaline medium. This has been demonstrated via comparison of catalytic performances of CoMoS, CoS, and MoS2...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098976/adsorption-neutralization-model-and-floc-growth-kinetics-properties-of-aluminum-coagulants-based-on-sips-and-boltzmann-equation
#20
Zhen Wu, Xian Zhang, Chunjiao Zhou, Jing-Lin Pang, Panyue P Zhang
Single-molecule aluminum salt AlCl3, medium polymerized polyaluminium chloride (PAC) and high polymerized polyaluminium chloride (HPAC) were prepared in laboratory. The characteristics and coagulation properties of these prepared aluminum salts were investigated. The Langmuir, Freundlich and Sips adsorption isotherms were firstly used to describe the adsorption neutralization process in coagulation, and the Boltzmann equation was used to fit the reaction kinetics of floc growth in flocculation. It was novel to find that the experimental data fitted well with the Sips and Boltzmann equation, and the significance of parameters in the equations was discussed simultaneously...
January 18, 2017: ACS Applied Materials & Interfaces
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