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https://www.readbyqxmd.com/read/29334247/development-of-fisetin-loaded-folate-functionalized-pluronic-micelles-for-breast-cancer-targeting
#1
Atmaram Pawar, Srishti Singh, S Rajalakshmi, Karimunnisa Shaikh, C Bothiraja
The natural flavonoid fisetin (FS) has shown anticancer properties but its in-vivo administration remains challenging due to its poor aqueous solubility. The aim of the study was to develop FS loaded pluronic127 (PF)-folic acid (FA) conjugated micelles (FS-PF-FA) by the way of increasing solubility, bioavailability and active targetability of FS shall increase its therapeutic efficacy. FA-conjugated PF was prepared by carbodiimide crosslinker chemistry. FS-PF-FA micelles were prepared by thin-film hydration method and evaluated in comparison with free FS and FS loaded PF micelles (FS-PF)...
January 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29334216/lysosome-independent-intracellular-drug-gene-co-delivery-by-lipoprotein-derived-nanovector-for-synergistic-apoptosis-inducing-cancer-targeted-therapy
#2
Wei Wang, Kerong Chen, Yujie Su, Jielei Zhang, Min Li, Jianping Zhou
In this paper, reconstituted high-density lipoprotein (rHDL), a lipoprotein-derived nanovector, were constructed for co-delivery of paclitaxel (PTX) and wild type p53 gene (p53). The particle size and the zeta potential of PTX-DODAB/p53-rHDL nanoparticles were 177.2 nm and -20.06 mV, respectively. Meanwhile, they exhibited great serum stability and satisfactory sustained release characteristics in vitro. PTX-DODAB/pDNA-rHDL nanoparticles simultaneously improved the cellular uptake of PTX and pDNA via scavenger receptor B type I (SR-BI) mediated lysosome-independent internalization and promoted the transfection of pDNA in MCF-7 cells, which were revealed by flow cytometry and confocal laser scanning microscopy analyses...
January 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29334147/uniform-lithium-nucleation-growth-induced-by-lightweight-nitrogen-doped-graphitic-carbon-foams-for-high-performance-lithium-metal-anodes
#3
Lin Liu, Ya-Xia Yin, Jin-Yi Li, Shu-Hua Wang, Yu-Guo Guo, Li-Jun Wan
The lithium metal anode has attracted soaring attention as an ideal battery anode. Unfortunately, nonuniform Li nucleation results in uncontrollable growth of dendritic Li, which incurs serious safety issues and poor electrochemical performance, hindering its practical applications. Herein, this study shows that uniform Li nucleation/growth can be induced by an ultralight 3D current collector consisting of in situ nitrogen-doped graphitic carbon foams (NGCFs) to realize suppressing dendritic Li growth at the nucleating stage...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29334116/interface-engineering-of-a-ceo2-cu3p-nanoarray-for-efficient-alkaline-hydrogen-evolution
#4
Zao Wang, Huitong Du, Zhiang Liu, Hui Wang, Abdullah M Asiri, Xuping Sun
It is of great importance to design and develop highly active electrocatalysts for the hydrogen evolution reaction (HER) under alkaline conditions. In this work, we report the development of a CeO2-Cu3P nanoarray supported on nickel foam (CeO2-Cu3P/NF) as an excellent HER catalyst with the demand of an overpotential of only 148 mV to deliver a geometrical catalytic current density of 20 mA cm-2 in 1.0 M KOH. Remarkably, this catalyst also shows strong long-term electrochemical durability for at least 100 h with nearly 100% Faradaic efficiency...
January 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29333850/engineering-nis-ni2p-heterostructures-for-efficient-electrocatalytic-water-splitting
#5
Xin Xiao, Dekang Huang, Yong Qing Richard Fu, Ming Wen, Xingxing Jiang, Xiaowei Lv, Man Li, Lin Gao, Shuangshuang Liu, Mingkui Wang, Chuan Zhao, Yan Shen
Developing high-active and low-cost bifunctional materials for catalyzing hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) holds pivotal role in water splitting. Therefore, we present a new strategy to form NiS/Ni2P heterostructures. The as-obtained NiS/Ni2P/CC requires overpotentials of 111 mV for the HER and 265 mV for the OER to reach a current density of 20 mA cm-2, outperforming their counterparts such as NiS and Ni2P under the same conditions. Additionally, the NiS/Ni2P/CC electrode requires a 1...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29333685/co-oh-2-nanoparticle-encapsulating-conductive-nanowires-array-room-temperature-electrochemical-preparation-for-high-performance-water-oxidation-electrocatalysis
#6
Dan Wu, Yicheng Wei, Xiang Ren, Xuqiang Ji, Yiwei Liu, Xiaodong Guo, Zhiang Liu, Abdullah M Asiri, Qin Wei, Xuping Sun
It is highly desired but still remains challenging to design and develop a Co-based nanoparticle-encapsulated conductive nanoarray at room temperature for high-performance water oxidation electrocatalysis. Here, it is reported that room-temperature anodization of a Co(TCNQ)2 (TCNQ = tetracyanoquinodimethane) nanowire array on copper foam at alkaline pH leads to in situ electrochemcial oxidation of TCNQ- into water-insoluable TCNQ nanoarray embedding Co(OH)2 nanoparticles. Such Co(OH)2 -TCNQ/CF shows superior catalytic activity for water oxidation and demands only a low overpotential of 276 mV to drive a geometrical current density of 25 mA cm-2 in 1...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333655/preparation-of-high-percentage-1t-phase-transition-metal-dichalcogenide-nanodots-for-electrochemical-hydrogen-evolution
#7
Chaoliang Tan, Zhimin Luo, Apoorva Chaturvedi, Yongqing Cai, Yonghua Du, Yue Gong, Ying Huang, Zhuangchai Lai, Xiao Zhang, Lirong Zheng, Xiaoying Qi, Min Hao Goh, Jie Wang, Shikui Han, Xue-Jun Wu, Lin Gu, Christian Kloc, Hua Zhang
Nanostructured transition metal dichalcogenides (TMDs) are proven to be efficient and robust earth-abundant electrocatalysts to potentially replace precious platinum-based catalysts for the hydrogen evolution reaction (HER). However, the catalytic efficiency of reported TMD catalysts is still limited by their low-density active sites, low conductivity, and/or uncleaned surface. Herein, a general and facile method is reported for high-yield, large-scale production of water-dispersed, ultrasmall-sized, high-percentage 1T-phase, single-layer TMD nanodots with high-density active edge sites and clean surface, including MoS2 , WS2 , MoSe2 , Mo0...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333330/amorphous-cobalt-vanadium-oxide-as-a-highly-active-electrocatalyst-for-oxygen-evolution
#8
Laurent Liardet, Xile Hu
The water-splitting reaction provides a promising mechanism to store renewable energies in the form of hydrogen fuel. The oxidation half-reaction, the oxygen evolution reaction (OER), is a complex four-electron process that constitutes an efficiency bottleneck in water splitting. Here we report a highly active OER catalyst, cobalt vanadium oxide. The catalyst is designed on the basis of a volcano plot of metal-OH bond strength and activity. The catalyst can be synthesized by a facile hydrothermal route. The most active pure-phase material (a-CoVO x ) is X-ray amorphous and provides a 10 mA cm-2 current density at an overpotential of 347 mV in 1 M KOH electrolyte when immobilized on a flat substrate...
January 5, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29330369/bio-templated-fabrication-of-three-dimensional-network-activated-carbons-derived-from-mycelium-pellets-for-supercapacitor-applications
#9
Junnan Hao, Yajing Huang, Chun He, Wenjun Xu, Libei Yuan, Dong Shu, Xiaona Song, Tao Meng
In this work, a three-dimensional porous mycelium-derived activated carbon (3D-MAC) was fabricated via a facile bio-templating method using mycelium pellets as both the carbon source and the bio-template. After ZnCl2 activation and high-temperature carbonization, the specific thread-like chain structure of mycelium in the pellets can be maintained effectively. The hyphae and junctions of the cross-linking hyphae form nanowires and carbon nanoparticles that link with the neighboring nanoparticles to form a network structure...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329916/impact-of-the-international-nosocomial-infection-control-consortium-s-multidimensional-approach-on-rates-of-ventilator-associated-pneumonia-in-14-intensive-care-units-in-11-hospitals-of-5-cities-within-argentina
#10
Victor Daniel Rosenthal, Javier Desse, Diego Marcelo Maurizi, Gustavo Jorge Chaparro, Pablo Wenceslao Orellano, Viviana Chediack, Rafael Cabrera, Daniel Golschmid, Cristina Graciela Silva, Julio Cesar Vimercati, Juan Pablo Stagnaro, Ivanna Perez, María Laura Spadaro, Adriana Miriam Montanini, Dina Pedersen, Teresa Laura Paniccia, Ana María Ríos Aguilera, Raul Cermesoni, Juan Ignacio Mele, Ernesto Alda, Analía Edith Paldoro, Agustín Román Ortta, Bettina Cooke, María Cecilia García, Mora Nair Obed, Cecilia Verónica Domínguez, Pablo Alejandro Saúl, María Cecilia Rodríguez Del Valle, Alberto Claudio Bianchi, Gustavo Alvarez, Ricardo Pérez, Carolina Oyola
BACKGROUND: To analyze the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach (IMA) on ventilator-associated pneumonia (VAP) rates in 11 hospitals within 5 cities of Argentina from January 2014-April 2017. METHODS: A multicenter, prospective, before-after surveillance study was conducted through the use of International Nosocomial Infection Control Consortium Surveillance Online System. During baseline, we performed outcome surveillance of VAP applying the definitions of the Centers for Disease Control andPrevention's National Healthcare Safety Network...
January 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29329264/engineering-ru-pt-core-shell-catalysts-for-enhanced-electrochemical-oxygen-reduction-mass-activity-and-stability
#11
Ariel Jackson, Alaina Strickler, Drew Higgins, Thomas Francisco Jaramillo
Improving the performance of oxygen reduction reaction (ORR) electrocatalysts is essential for the commercial efficacy of many renewable energy technologies, including low temperature polymer electrolyte fuel cells (PEFCs). Herein, we report highly active and stable carbon-supported Ru@Pt core-shell nanoparticles (Ru@Pt/C) prepared by a wet chemical synthesis technique. Through rotating disc electrode testing, the Ru@Pt/C achieves an ORR Pt mass-based activity of 0.50 A mgPt-1 at 0.9 V versus the reversible hydrogen electrode (RHE), which exceeds the activity of the state-of-the-art commercial Pt/C catalyst as well as the Department of Energy 2020 PEFC electrocatalyst activity targets for transportation applications...
January 12, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29329206/preparation-of-cu%C3%A2-o-reduced-graphene-nanocomposite-modified-electrodes-towards-ultrasensitive-dopamine-detection
#12
Quanguo He, Jun Liu, Xiaopeng Liu, Guangli Li, Peihong Deng, Jing Liang
Cu₂O-reduced graphene oxide nanocomposite (Cu₂O-RGO) was used to modify glassy carbon electrodes (GCE), and applied for the determination of dopamine (DA). The microstructure of Cu₂O-RGO nanocomposite material was characterized by scanning electron microscope. Then the electrochemical reduction condition for preparing Cu₂O-RGO/GCE and experimental conditions for determining DA were further optimized. The electrochemical behaviors of DA on the bare electrode, RGO- and Cu₂O-RGO-modified electrodes were also investigated using cyclic voltammetry in phosphate-buffered saline solution (PBS, pH 3...
January 12, 2018: Sensors
https://www.readbyqxmd.com/read/29328930/enhanced-treatment-of-petroleum-refinery-wastewater-by-short-term-applied-voltage-in-single-chamber-microbial-fuel-cell
#13
Gunda Mohanakrishna, Ibrahim M Abu-Reesh, Sanath Kondaveeti, Riyadh I Al-Raoush, Zhen He
Electrochemically active anodic biofilm that has adapted under mild applied potentials in the range 100-500 mV was evaluated for its improved bioelectrogenesis and bioelectrochemical treatment of petroleum refinery wastewater (PRW) in a single chamber air cathode microbial fuel cell (MFC). MFC operation with 500 mV as supplemental voltage has exhibited a maximum power density of 132 mW/m2, which was three times higher than control MFC (45 mW/m2). Similarly, highest substrate removal efficiency (48%) was also obtained with the MFC of 500 mV, followed by 300 mV (37%), 100 mV (32%) and control (27%)...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29328733/understanding-quality-factor-degradation-in-superconducting-niobium-cavities-at-low-microwave-field-amplitudes
#14
A Romanenko, D I Schuster
In niobium superconducting radio frequency (SRF) cavities for particle acceleration, a decrease of the quality factor at lower fields-a so-called low field Q slope or LFQS-has been a long-standing unexplained effect. By extending the high Q measurement techniques to ultralow fields, we discover two previously unknown features of the effect: (i) saturation at rf fields lower than E_{acc}∼0.1  MV/m; (ii) strong degradation enhancement by growing thicker niobium pentoxide. Our findings suggest that the LFQS may be caused by the two level systems in the natural niobium oxide on the inner cavity surface, thereby identifying a new source of residual resistance and providing guidance for potential nonaccelerator low-field applications of SRF cavities...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328533/cobaltocenylidene-a-mesoionic-metalloceno-carbene-stabilized-in-a-gold-iii-complex
#15
Benno Bildstein, Stefan Vanicek, Maren Podewitz, Christopher Hassenrück, Michael Pittracher, Holger Kopacka, Klaus Wurst, Thomas Müller, Klaus R Liedl, Rainer F Winter
Oxidative addition of cobaltoceniumdiazonium bis(hexafluoridophosphate) with (pseudo)halide aurates afforded gold(III) complexes containing zwitterionic cobaltoceniumide as a ligand. Its selenium derivative, cobaltoceniumselenolate, was obtained by an electrophilic aromatic substitution reaction of iodocobaltocenium iodide with Na2Se. Spectroscopic and structural data in combination with DFT calculations show that this cobaltocenylidene species is a mesoionic carbene quite different from common N-heterocyclic carbenes...
January 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29327937/synthesis-structure-and-property-of-corona-6-arenes-and-their-assembly-with-anions-in-the-crystalline-state
#16
Meng-Yao Zhao, De-Xian Wang, Mei-Xiang Wang
The synthesis, conformational structure, electronic property and anion complexation of novel coronarenes were systematically studied. A number of corona[4]arene[2]tetrazines that contain different combinations of nitrogen atom with O, S, SO2 and CH2 as bridging units were synthesized conveniently by means of a fragment coupling strategy based on efficient nucleophilic aromatic substitution reaction of easily available aromatic dinucleophiles and 3,6-dichlorotetrazine. The resulting macrocycles adopt coronary conformational structures with the nitrogen bridge(s) forming conjugation with carbonyl and the other heteroatom linkages with tetrazine...
January 12, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29327597/endothelial-cell-derived-microvesicles-potential-mediators-and-biomarkers-of-pathologic-processes
#17
Veronika Vítková, Jan Živný, Jan Janota
This review focuses on the formation, composition and function of endothelial microvesicles (MV), often called microparticles (MP). MV release is a controlled event and is considered a hallmark of cellular activation or alteration. MV may affect the function of target cells through surface interaction and receptor activation, cellular fusion and the delivery of intravesicular cargo. Endothelial MV are released as a consequence of endothelial activation during inflammation and have been described to affect hemostasis, various aspects of inflammatory reaction, vessel formation, apoptosis and cell survival, endothelial cell differentiation and function...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327475/tuning-the-activity-of-carbon-for-electrocatalytic-hydrogen-evolution-via-an-iridium-cobalt-alloy-core-encapsulated-in-nitrogen-doped-carbon-cages
#18
Peng Jiang, Jitang Chen, Changlai Wang, Kang Yang, Shipeng Gong, Shuai Liu, Zhiyu Lin, Mengsi Li, Guoliang Xia, Yang Yang, Jianwei Su, Qianwang Chen
Graphene, a 2D material consisting of a single layer of sp2 -hybridized carbon, exhibits inert activity as an electrocatalyst, while the incorporation of heteroatoms (such as N) into the framework can tune its electronic properties. Because of the different electronegativity between N and C atoms, electrons will transfer from C to N in N-doped graphene nanosheets, changing inert C atoms adjacent to the N-dopants into active sites. Notwithstanding the achieved progress, its intrinsic activity in acidic media is still far from Pt/C...
January 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29327259/5-aminolevulinic-acid-squalene-nanoassemblies-for-tumor-photodetection-and-therapy-in-vitro-studies
#19
Andrej Babič, V Herceg, E Bastien, H-P Lassalle, L Bezdetnaya, Norbert Lange
Protoporphyrin IX (PpIX) as natural photosensitizer derived from administration of 5-aminolevulinic acid (5-ALA) has found clinical use for photodiagnosis and photodynamic therapy of several cancers. However, broader use of 5-ALA in oncology is hampered by its charge and polarity that result in its reduced capacity for passing biological barriers and reaching the tumor tissue. Advanced drug delivery platforms are needed to improve the biodistribution of 5-ALA. Here, we report a new approach for the delivery of 5-ALA...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29327165/measurement-of-cardiac-valve-and-aortic-blood-flow-velocities-in-stroke-patients-a-comparison-of-4d-flow-mri-and-echocardiography
#20
Thomas Wehrum, Felix Guenther, Alexander Fuchs, Florian Schuchardt, Anja Hennemuth, Andreas Harloff
4D flow MRI is an emerging technique that allows quantification of 3D blood flow in vivo. However, comparisons with methods of blood velocity quantification used in clinical routine are sparse. Therefore, we compared velocity quantification using 4D flow MRI with transthoracic and transesophageal echocardiography at the mitral and aortic valves and the aorta. Forty-eight stroke patients (age 67.3 ± 15.0 years) were examined by 4D flow MRI. Blood flow velocities were assessed using standardized 2D analysis planes positioned in the mitral valve (MV), aortic valve (AV), ascending aorta (AAo), and descending aorta (DAo) and were compared with echocardiography...
January 11, 2018: International Journal of Cardiovascular Imaging
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