keyword
https://read.qxmd.com/read/37528068/delayed-step-by-step-decompression-with-dsf-alleviates-skeletal-muscle-crush-injury-by-inhibiting-nlrp3-casp-1-gsdmd-pathway
#21
JOURNAL ARTICLE
Ning Li, Xinyue Wang, Yuru Wang, Pengtao Wang, Na Sun, Jiale Chen, Lu Han, Zizheng Li, Haojun Fan, Yanhua Gong
Crush injury (CI) is a common disease in earthquake and traffic accidents. It refers to long-term compression that induces ischemia and hypoxia injury of skeletal muscle rich parts, leading to rupture of muscle cells and release of contents into the blood circulation. Crush syndrome (CS) is the systemic manifestation of severe, traumatic muscle injury. CI rescue faces a dilemma. Ischemic reperfusion due to decompression is a double-edged sword for the injured. Death often occurs when the injured are glad to be rescued...
August 1, 2023: Cell Death Discovery
https://read.qxmd.com/read/37516431/mitochondrial-modulation-of-amplified-preconditioning-influences-of-remote-ischemia-plus-erythropoietin-against-skeletal-muscle-ischemia-reperfusion-injury-in-rats
#22
JOURNAL ARTICLE
Asmaa A Khalifa, Mennatallah A Ali, Nahed H Elsokkary, Samar S Elblehi, Mahmoud M El-Mas
AIMS: Skeletal muscle ischemia and reperfusion (S-I/R) injury is relieved by interventions like remote ischemic preconditioning (RIPC). Here, we tested the hypothesis that simultaneous exposure to a minimal dose of erythropoietin (EPO) boosts the protection conferred by RIPC against S-I/R injury and concomitant mitochondrial oxidative and apoptotic defects. MAIN METHODS: S-I/R injury was induced in rats by 3-h right hindlimb ischemia followed by 3-h of reperfusion, whereas RIPC involved 3 brief consecutive I/R cycles of the contralateral hindlimb...
July 27, 2023: Life Sciences
https://read.qxmd.com/read/37508336/probdnf-upregulation-in-murine-hind-limb-ischemia-reperfusion-injury-a-driver-of-inflammation
#23
JOURNAL ARTICLE
Katherine Aby, Ryan Antony, Yifan Li
Brain-derived neurotropic factor (BDNF) has been shown to be expressed in many nonneuronal tissues including skeletal muscle. Skeletal muscle BDNF has been studied regarding its function in metabolism and exercise; however, less is known about its role in skeletal muscle injury. The precursor to BDNF, proBDNF, has an unknown role in skeletal muscle. The levels of proBDNF, mature BDNF, and their receptors were compared in the skeletal muscle and brain tissues of C57BL/6J mice. Tourniquet-induced hind limb ischemia-reperfusion injury was used to assess the function of skeletal muscle-derived proBDNF in skeletal muscle injury...
June 24, 2023: Biology
https://read.qxmd.com/read/37484837/effect-of-valproic-acid-upon-skeletal-muscle-subjected-to-prolonged-tourniquet-application
#24
JOURNAL ARTICLE
Robert Moritz, Lee Mangum, Chet Voelker, Gerardo Garcia, Joseph Wenke
BACKGROUND: Valproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries. This study was designed to investigate the ability of VPA to mitigate ischemia-reperfusion injury produced by prolonged tourniquet application to an extremity. METHODS: The ischemia-reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application...
2023: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/37462424/sulforaphane-protects-microvascular-endothelial-cells-in-lower-limb-ischemia-reperfusion-injury-mice
#25
JOURNAL ARTICLE
Fanfeng Chen, Jiayu Zhan, Abdullah Al Mamun, Yibing Tao, Shanshan Huang, Jiaxin Zhao, Yu Zhang, Yitie Xu, Shenghu Du, Wei Lu, Xiaokun Li, Zimiao Chen, Jian Xiao
Background : Microvascular damage is a key pathological factor in acute lower limb ischemia/reperfusion (I/R) injury. Current evidence suggests that sulforaphane (SFN) protects tissue from I/R injury. However, the role of SFN in acute lower limb I/R injury remains elusive. This study aimed to investigate the role and potential mechanism of SFN in I/R-related microvascular damage in the limb. Methods : Limb viability was evaluated by laser Doppler imaging, tissue edema analysis and histological analysis. Western blotting and immunofluorescence were applied to analyze the levels of apoptosis, oxidative stress, autophagy, transcription factor EB (TFEB) activity and mucolipin 1 (MCOLN1)-calcineurin signaling pathway...
July 18, 2023: Food & Function
https://read.qxmd.com/read/37447175/a-mango-leaf-extract-zynamite-%C3%A2-combined-with-quercetin-has-exercise-mimetic-properties-in-human-skeletal-muscle
#26
JOURNAL ARTICLE
Miriam Martinez-Canton, Victor Galvan-Alvarez, Eduardo Garcia-Gonzalez, Angel Gallego-Selles, Miriam Gelabert-Rebato, Giovanni Garcia-Perez, Alfredo Santana, Laura Lopez-Rios, Tanausu Vega-Morales, Marcos Martin-Rincon, Jose A L Calbet
Zynamite PX® , a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite® + 140 mg quercetin/8 h for 2 days). Then, they performed incremental exercise to exhaustion (IE) followed by occlusion of the circulation in one leg for 60 s. Afterwards, the cuff was released, and a 30 s sprint was performed, followed by 90 s circulatory occlusion (same leg)...
June 23, 2023: Nutrients
https://read.qxmd.com/read/37443314/cytochrome-c-lysine-acetylation-regulates-cellular-respiration-and-cell-death-in-ischemic-skeletal-muscle
#27
JOURNAL ARTICLE
Paul T Morse, Gonzalo Pérez-Mejías, Junmei Wan, Alice A Turner, Inmaculada Márquez, Hasini A Kalpage, Asmita Vaishnav, Matthew P Zurek, Philipp P Huettemann, Katherine Kim, Tasnim Arroum, Miguel A De la Rosa, Dipanwita Dutta Chowdhury, Icksoo Lee, Joseph S Brunzelle, Thomas H Sanderson, Moh H Malek, David Meierhofer, Brian F P Edwards, Irene Díaz-Moreno, Maik Hüttemann
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial respiration and apoptosis. Here, we describe an acetylation site of Cytc, lysine 39 (K39), which was mapped in ischemic porcine skeletal muscle and removed by sirtuin5 in vitro. Using purified protein and cellular double knockout models, we show that K39 acetylation and acetylmimetic K39Q replacement increases cytochrome c oxidase (COX) activity and ROS scavenging while inhibiting apoptosis via decreased binding to Apaf-1, caspase cleavage and activity, and cardiolipin peroxidase activity...
July 13, 2023: Nature Communications
https://read.qxmd.com/read/37251271/e-selectin-aav-gene-therapy-promotes-myogenesis-and-skeletal-muscle-recovery-in-a-mouse-hindlimb-ischemia-model
#28
JOURNAL ARTICLE
Antoine J Ribieras, Yulexi Y Ortiz, Yan Li, Nga T Le, Carlos T Huerta, Francesca A Voza, Hongwei Shao, Roberto I Vazquez-Padron, Zhao-Jun Liu, Omaida C Velazquez
The response to ischemia in peripheral artery disease (PAD) depends on compensatory neovascularization and coordination of tissue regeneration. Identifying novel mechanisms regulating these processes is critical to the development of nonsurgical treatments for PAD. E-selectin is an adhesion molecule that mediates cell recruitment during neovascularization. Therapeutic priming of ischemic limb tissues with intramuscular E-selectin gene therapy promotes angiogenesis and reduces tissue loss in a murine hindlimb gangrene model...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37246769/a-pilot-study-of-ratiometric-creatine-cest-mri-assessment-of-rabbit-skeletal-muscle-energy-metabolism-at-3%C3%A2-t
#29
JOURNAL ARTICLE
Jialei Zhao, Gang Wu, Qiting Wu, Pengcheng Gong, Junfeng Kuang, Hairong Zheng, Phillip Zhe Sun, Ye Li, Yin Wu
BACKGROUND: pH MRI may provide useful information to evaluate metabolic disruption following ischemia. Radiofrequency amplitude-based creatine chemical exchange saturation transfer (CrCEST) ratiometric MRI is pH-sensitive, which could but has not been explored to examine muscle ischemia. PURPOSE: To investigate skeletal muscle energy metabolism alterations with CrCEST ratiometric MRI. STUDY TYPE: Prospective. ANIMAL MODEL: Seven adult New Zealand rabbits with ipsilateral hindlimb muscle ischemia...
May 29, 2023: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/37210237/severe-muscle-damage-after-a-short-period-of-ischemia-and-reperfusion-in-an-animal-model
#30
JOURNAL ARTICLE
Enzo Gallo de Carvalho, Wagner Corsini, Túlio de Almeida Hermes
BACKGROUND: Skeletal muscle ischemia-reperfusion injuries result in a loss of contractile function, leading to limb disability or amputation. Ischemia causes hypoxia and cellular energy failure, which is aggravated by reperfusion due to the inflammatory response and oxidative stress. The consequences of the injury vary according to the duration of the period of ischemia and reperfusion. Therefore, the present work aims to evaluate ischemia-reperfusion injuries induced in the skeletal muscles of Wistar rats submitted to 3 different application periods based on morphological and biochemical parameters...
May 18, 2023: Surgery
https://read.qxmd.com/read/37145937/the-effect-of-electrical-stimulation-of-skeletal-muscle-on-cardioprotection-and-on-muscle-derived-myokine-levels-in-rats-a-pilot-study
#31
JOURNAL ARTICLE
Márton R Szabó, Tamás Csont, Csaba Csonka
Electrical muscle stimulation (EMS) is a widely used method in sports and rehabilitation therapies to simulate physical exercise. EMS treatment via skeletal muscle activity improves the cardiovascular functions and the overall physical condition of the patients. However, the cardioprotective effect of EMS has not been proven so far, therefore, the aim of this study was to investigate the potential cardiac conditioning effect of EMS in an animal model. Low-frequency 35-min EMS was applied to the gastrocnemius muscle of male Wistar rats for three consecutive days...
May 5, 2023: Physiology International
https://read.qxmd.com/read/37100885/microvascular-and-oxidative-stress-responses-to-acute-high-altitude-exposure-in-prematurely-born-adults
#32
JOURNAL ARTICLE
Giorgio Manferdelli, Benjamin J Narang, Vincent Pialoux, Guido Giardini, Tadej Debevec, Grégoire P Millet
Premature birth is associated with endothelial and mitochondrial dysfunction, and chronic oxidative stress, which might impair the physiological responses to acute altitude exposure. We assessed peripheral and oxidative stress responses to acute high-altitude exposure in preterm adults compared to term born controls. Post-occlusive skeletal muscle microvascular reactivity and oxidative capacity from the muscle oxygen consumption recovery rate constant (k) were determined by Near-Infrared Spectroscopy in the vastus lateralis of seventeen preterm and seventeen term born adults...
April 26, 2023: Scientific Reports
https://read.qxmd.com/read/37051831/systemic-glucose-insulin-potassium-reduces-skeletal-muscle-injury-kidney-injury-and-pain-in-a-murine-ischaemia-reperfusion-model
#33
JOURNAL ARTICLE
Daniel B Buchalter, David J Kirby, Utkarsh Anil, Sanjit R Konda, Philipp Leucht
Glucose-insulin-potassium (GIK) is protective following cardiac myocyte ischaemia-reperfusion (IR) injury, however the role of GIK in protecting skeletal muscle from IR injury has not been evaluated. Given the similar mechanisms by which cardiac and skeletal muscle sustain an IR injury, we hypothesized that GIK would similarly protect skeletal muscle viability. A total of 20 C57BL/6 male mice (10 control, 10 GIK) sustained a hindlimb IR injury using a 2.5-hour rubber band tourniquet. Immediately prior to tourniquet placement, a subcutaneous osmotic pump was placed which infused control mice with saline (0...
March 9, 2023: Bone & Joint Research
https://read.qxmd.com/read/36979152/ischemic-conditioning-to-reduce-fatigue-in-isometric-skeletal-muscle-contraction
#34
JOURNAL ARTICLE
Ruben Allois, Pasquale Pagliaro, Silvestro Roatta
Ischemic preconditioning (IPC) is a non-invasive protective maneuver that alternates short periods of occlusion and reperfusion of tissue blood flow. Given the heterogeneity in the magnitude and frequency of IPC-induced improvements in physical performance, here we aimed to investigate, in a well-controlled experimental set-up, the local effects of IPC in exposed muscles in terms of tissue oxygenation and muscle fatigue. Nineteen subjects were enrolled in one of the two groups, IPC (3 × 5/5 min right arm ischemia/reperfusion; cuff inflations 250 mmHg) and SHAM (3 × 5/5 min pseudo ischemia/reperfusion; 20 mmHg)...
March 16, 2023: Biology
https://read.qxmd.com/read/36952087/skeletal-muscle-oxidative-adaptations-following-localized-heat-therapy
#35
JOURNAL ARTICLE
Mohammed Ihsan, Mariem Labidi, Sebastien Racinais
Repeated heat treatment has been shown to induce oxidative adaptations in cell cultures and rodents, but similar work within human models is scarce. This study investigated the effects of 6 weeks of localized heat therapy on near-infrared spectroscopy-(NIRS) derived indices of muscle oxidative and microvascular function. Twelve physically active participants (8 males and 4 females, age: 34.9 ± 5.9 years, stature: 175 ± 7 cm, body mass: 76.7 ± 13...
March 23, 2023: European Journal of Applied Physiology
https://read.qxmd.com/read/36939886/the-forkhead-box-o3-foxo3-a-key-player-in-the-regulation-of-ischemia-and-reperfusion-injury
#36
REVIEW
Moussa Omorou, Yiwei Huang, Meng Gao, Chenxi Mu, Weijing Xu, Yuchun Han, Hui Xu
Forkhead box O3 is a protein encoded by the FOXO3 gene expressed throughout the body. FOXO3 could play a crucial role in longevity and many other pathologies, such as Alzheimer's disease, glioblastoma, and stroke. This study is a comprehensive review of the expression of FOXO3 under ischemia and reperfusion (IR) and the molecular mechanisms of its regulation and function. We found that the expression level of FOXO3 under ischemia and IR is tissue-specific. Specifically, the expression level of FOXO3 is increased in the lung and intestinal epithelial cells after IR...
March 20, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/36888762/effect-of-dexmedetomidine-on-tourniquet-induced-skeletal-muscle-injury
#37
JOURNAL ARTICLE
Wenjie Cheng, Zhe Wu, Jizheng Zhang, Wanlu Ren
OBJECTIVE: The aim of this study was to investigate whether dexmedetomidine could reduce tourniquet-induced skeletal muscle injury. METHODS: C57BL6 male mice were randomly assigned to sham, ischemia/reperfusion, and dexmedetomidine groups. Mice in the ischemia/reperfusion and dexmedetomidine groups received normal saline solution and dexmedetomidine intraperitoneally, respectively. The sham group underwent the same procedure as the ischemia/reperfusion group, with the exception of tourniquet application...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/36860545/diminished-adipor1-appl1-interaction-mediates-reduced-cardioprotective-actions-of-adiponectin-against-myocardial-ischemia-reperfusion-injury-in-type-2-diabetic-mice
#38
JOURNAL ARTICLE
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang
BACKGROUND: Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack with decreased plasma lipocalin levels, and lipocalin is negatively correlated with heart attack incidence. APPL1 is a signaling protein with multiple functional structural domains and plays an important role in the APN signaling pathway...
2023: Stem Cells International
https://read.qxmd.com/read/36852300/dnase-i-and-sivelestat-ameliorate-experimental-hindlimb-ischemia-reperfusion-injury-by-eliminating-neutrophil-extracellular-traps
#39
JOURNAL ARTICLE
Chun-Lian Wang, Yan Wang, Qi-Lan Jiang, Yang Zeng, Qing-Ping Yao, Xing Liu, Tao Li, Jun Jiang
PURPOSE: Neutrophil extracellular traps (NETs) play an important role in ischemia-reperfusion injury (IRI) of the hindlimb. The aim of this study was to investigate the effect of recombinant DNase I and sivelestat in eliminating NETs and their effects on IRI limbs. PATIENTS AND METHODS: An air pump was used to apply a pressure of 300 mmHg to the root of the right hindlimb of the rat for 2 h and then deflated to replicate the IRI model. The formation of NETs was determined by the detection of myeloperoxidase (MPO), neutrophil elastase (NE), and histone H3 in the skeletal muscles of the hindlimbs...
2023: Journal of Inflammation Research
https://read.qxmd.com/read/36836038/the-possibility-of-ipc-to-prevent-ischemic-reperfusion-injury-in-skeletal-muscle-in-a-rat
#40
JOURNAL ARTICLE
Takanori Morikawa, Miyako Shimasaki, Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Kan Takahashi
Blood removal with air tourniquets for a long time induces muscle damage after reperfusion. Ischemic preconditioning (IPC) has a protective effect against ischemia-reperfusion injury in striated muscle and myocardium. However, the mechanism of action of IPC on skeletal muscle injury is unclear. Thus, this study aimed to investigate the effect of IPC in reducing skeletal muscle damage caused by ischemia-reperfusion injury. The hindlimbs of 6-month-old rats were wounded with air tourniquets at a carminative blood pressure of 300 mmHg on the thighs...
February 14, 2023: Journal of Clinical Medicine
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