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Skeletal muscle reperfusion

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https://www.readbyqxmd.com/read/29660904/ryanodine-receptor-antagonism-alleviates-skeletal-muscle-ischemia-reperfusion-injury-by-modulating-tnf-%C3%AE-and-il-10
#1
Hai-Peng Lin, Yan-Qing Zheng, Zhi-Ping Zhou, Gao-Xiong Wang, Ping-Fan Guo
BACKGROUND: Intracellular calcium overload has been implicated in various pathological conditions including ischemia reperfusion injury. This study aims to explore the effect and probable mechanism of dantrolene, a ryanodine receptor and intracellular calcium antagonist, on the skeletal muscle ischemia reperfusion injury. MATERIALS AND METHODS: SD rats were randomly divided into three groups: sham group which underwent anaesthesia and exposure of femoral vein, reperfusion group that received 2 h ischemia and the amount of diluent via femoral vein before 4 h reperfusion, dantrolene group that underwent 2 h ischemia and was given 2 mg/kg dantrolene via femoral vein before 4 h reperfusion...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29615933/dexamethasone-protects-against-tourniquet-induced-acute-ischemia-reperfusion-injury-in-mouse-hindlimb
#2
Ryan M Corrick, Huiyin Tu, Dongze Zhang, Aaron N Barksdale, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexamethasone, an anti-inflammatory drug, on tourniquet-induced acute IR injury in mouse hindlimb...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29602289/effect-of-iloprost-on-contractile-impairment-and-mitochondrial-degeneration-in-ischemia-reperfusion-of-skeletal-muscle
#3
Z Bagis, M Ozeren, B Buyukakilli, E Balli, S Yaman, D Yetkin, D Ovla
Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model. Main Methods Forty Wistar albino rats were randomly divided into a control group and four experimental groups...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29515706/pretreatment-with-the-free-radical-scavenger-edaravone-mitigates-kidney-glycogen-depletion-and-neutrophil-infiltration-after-leg-ischemia-in-a-rat-model-a-pilot-study
#4
Mitsuhiro Yamamura, Yuji Miyamoto, Masataka Mitsuno, Hiroe Tanaka, Masaaki Ryomoto
Objective : We have previously shown that pretreatment with the free radical scavenger edaravone (Radicut® , Mitsubishi Tanabe Pharma Co., Japan) mitigated skeletal muscle damage due to ischemia reperfusion. In this study, we sought to validate its use in an experimental model of myonephropathic-metabolic syndrome (MNMS). Methods : Either edaravone (3.0 mg/kg; edaravone group; n=4) or saline (saline group; n=6) was intraperitoneally injected into male Lewis rats (508±31 g). Normal kidneys were harvested as control (n=3)...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29512311/nitrite-as-a-pharmacological-intervention-for-the-successful-treatment-of-crush-syndrome
#5
REVIEW
Jun Kobayashi, Isamu Murata
Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen species and subsequent systemic inflammation. Therefore, ischemic pre and postconditioning are performed in clinical practice. Intravenous administration of nitrite inhibits IRI through nitric oxide-mediated mechanisms...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29498531/clinical-translation-of-myocardial-conditioning
#6
Hans Erik Botker, Thomas Ravn Lassen, Nichlas Riise Jespersen
Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy have improved outcome in patients with ST-elevation myocardial infarction. The next major target to further improve outcome, seems to be ischemia reperfusion injury, which may contribute significantly to the final infarct size and hence mortality and post-infarction heart failure. Mechanical conditioning strategies including local and remote ischemic pre-, per- and postconditioning have demonstrated consistent cardioprotective capacities in experimental models of acute IR injury...
March 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29488785/highs-and-lows-of-hyperoxia-physiological-performance-and-clinical-aspects
#7
Julien Vincent Brugniaux, Geoff B Coombs, Otto F Barak, Zeljko Dujic, Mypinder S Sekhon, Philip N Ainslie
Molecular oxygen (O2 ) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content (CaO2 ), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Nevertheless, with various degrees of effectiveness, and not without consequences, supplemental oxygen is used clinically in an attempt to correct tissue hypoxia (e...
February 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29487339/ablation-of-bax-and-bak-protects-skeletal-muscle-against-pressure-induced-injury
#8
Bjorn T Tam, Angus P Yu, Eric W Tam, Douglas A Monks, Xu P Wang, Xiao M Pei, Su P Koh, Thomas K Sin, Helen K W Law, Felix N Ugwu, Rashmi Supriya, Benjamin Y Yung, Shea P Yip, S C Wong, Lawrence W Chan, Christopher W Lai, Pin Ouyang, Parco M Siu
Pressure-induced injury (PI), such as a pressure ulcer, in patients with limited mobility is a healthcare issue worldwide. PI is an injury to skin and its underlying tissue such as skeletal muscle. Muscle compression, composed of mechanical deformation of muscle and external load, leads to localized ischemia and subsequent unloading reperfusion and, hence, a pressure ulcer in bed-bound patients. Although the gross factors involved in PI have been identified, little is known about the exact disease mechanism or its links to apoptosis, autophagy and inflammation...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432799/mitochondrial-protein-s-nitrosation-protects-against-ischemia-reperfusion-induced-denervation-at-neuromuscular-junction-in-skeletal-muscle
#9
Rebecca J Wilson, Joshua C Drake, Di Cui, Bevan M Lewellen, Carleigh C Fisher, Mei Zhang, David F Kashatus, Lisa A Palmer, Michael P Murphy, Zhen Yan
Deterioration of neuromuscular junction (NMJ) integrity and function is causal to muscle atrophy and frailty, ultimately hindering quality of life and increasing the risk of death. In particular, NMJ is vulnerable to ischemia reperfusion (IR) injury when blood flow is restricted followed by restoration. However, little is known about the underlying mechanism(s) and hence the lack of effective interventions. New evidence suggests that mitochondrial oxidative stress plays a causal role in IR injury, which can be precluded by enhancing mitochondrial protein S-nitrosation (SNO)...
February 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29425473/beetroot-increases-muscle-performance-and-oxygenation-during-sustained-isometric-exercise-but-does-not-alter-muscle-oxidative-efficiency-and-microvascular-reactivity-at-rest
#10
Stavros Papadopoulos, Konstantina Dipla, Areti Triantafyllou, Michalis G Nikolaidis, Antonios Kyparos, Panagiota Touplikioti, Ioannis S Vrabas, Andreas Zafeiridis
OBJECTIVE: To examine the effects of beetroot juice (BRJ) on (i) in vivo skeletal muscle O2 consumption (mVO2) and microvascular reactivity at rest and (ii) muscle performance, muscle oxygenation, and mVO2 during sustained isometric handgrip exercise (IHG). METHODS: Sixteen young males consumed, randomly, a nitrate-rich (8.1 mmol BRJnitrate) or nitrate-depleted (BRJplacebo) BRJ. After 2.5 hours, they performed an occlusion-reperfusion maneuver at rest, a 3-minute sustained IHG, and a sustained IHG to exhaustion with arterial occlusion...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29395744/tourniquet-time-in-total-knee-arthroplasty
#11
Lasse E Rasmussen, Henriette A Holm, Per W Kristensen, Per Kjaersgaard-Andersen
BACKGROUND: Whether the arterial tourniquet in total knee arthroplasty (TKA) is a friend or a foe is still debated. Longer ischemia causes hypoxic damage; yet short duration of a tourniquet may influence outcome. Understanding the time-dependent influence of the tourniquet in TKA patients could improve the overall outcome and safety. The purpose of the study was to measure the tourniquet-induced time-dependent alterations in skeletal muscle metabolism in TKA to establish a 'safe tourniquet time...
January 26, 2018: Knee
https://www.readbyqxmd.com/read/29385043/interplay-between-ros-and-antioxidants-during-ischemia-reperfusion-injuries-in-cardiac-and-skeletal-muscle
#12
REVIEW
Tingyang Zhou, Evan R Prather, Davis E Garrison, Li Zuo
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29384781/systemic-administration-of-carbon-monoxide-releasing-molecule-3-protects-the-skeletal-muscle-in-porcine-model-of-compartment-syndrome
#13
Aurelia Bihari, Gediminas Cepinskas, David Sanders, Abdel-Rahman Lawendy
OBJECTIVES: Acute limb compartment syndrome, a complication of musculoskeletal trauma, results in muscle necrosis and cell death. Carbon monoxide, liberated from the carbon monoxide-releasing molecule-3, has been shown protective in a rat model of compartment syndrome. The purpose of this study was to test the effect of carbon monoxide-releasing molecule-3 in a preclinical large animal model of compartment syndrome, with the ultimate goal of developing a pharmacologic adjunct treatment for compartment syndrome...
January 30, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29370063/fresh-whole-blood-resuscitation-does-not-exacerbate-skeletal-muscle-edema-and-long-term-functional-deficit-after-ischemic-injury-and-hemorrhagic-shock
#14
Amit Aurora, Janet L Roe, Nsini A Umoh, Michael Dubick, Joseph C Wenke, Thomas J Walters
BACKGROUND: Hemorrhagic shock due to extremity vascular injuries is common in combat injuries. Fluid resuscitation is the standard treatment for severe hemorrhage. Tourniquets (TK) used for hemorrhage control cause ischemia-reperfusion (I/R) injury that induces edema formation in the injured muscle. Resuscitation fluids affect edema formation; however, its effect on long-term functional response remains unknown. The objectives of this study are 1) compare acute muscle damage; 2) determine long-term functional recovery of ischemic muscle, and 3) compare local and systemic inflammatory response including the expression of junctional proteins following early resuscitation with Hextend (HEX) and Fresh Whole Blood (FWB) using a rodent model of combined hemorrhage and TK-induced limb I/R...
January 24, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29336387/dexmedetomidine-for-prevention-of-skeletal-muscle-ischaemia-reperfusion-injury-in-patients-with-chronic-limb-ischaemia-undergoing-aortobifemoral-bypass-surgery-a-prospective-double-blind-randomized-controlled-study
#15
Tanveer Singh Kundra, Ashwini Thimmarayappa, Manasa Dhananjaya, N Manjunatha
BACKGROUND: Dexmedetomidine is a selective α-2 agonist used for sedation. It has also been shown to have myocardial protective effect and prevent ischemia-reperfusion injury in off-pump coronary artery bypass patients. The aim of our study was to assess the effect of dexmedetomidine for prevention of skeletal muscle ischemia-reperfusion injury in patients undergoing aortobifemoral bypass surgery. METHODOLOGY: Sixty adult patients (Group dexmedetomidine n = 30, Group normal saline n = 30) undergoing aortobifemoral bypass surgery were recruited over 3 months...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29274400/conditional-mitotimer-reporter-mice-for-assessment-of-mitochondrial-structure-oxidative-stress-and-mitophagy
#16
Rebecca J Wilson, Joshua C Drake, Di Cui, Mei Zhang, Heather M Perry, Jennifer A Kashatus, Christine M Kusminski, Philipp E Scherer, David F Kashatus, Mark D Okusa, Zhen Yan
Assessment of structural and functional changes of mitochondria is vital for biomedical research as mitochondria are the power plants essential for biological processes and tissue/organ functions. Others and we have developed a novel reporter gene, pMitoTimer, which codes for a redox sensitive mitochondrial targeted protein that switches from green fluorescence protein (GFP) to red fluorescent protein (DsRed) when oxidized. It has been shown in transfected cells, transgenic C. elegans and Drosophila m., as well as somatically transfected adult skeletal muscle that this reporter gene allows quantifiable assessment of mitochondrial structure, oxidative stress, and lysosomal targeting of mitochondria-containing autophagosomes...
December 20, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29187642/irisin-protects-mitochondria-function-during-pulmonary-ischemia-reperfusion-injury
#17
Ken Chen, Zaicheng Xu, Yukai Liu, Zhen Wang, Yu Li, Xuefei Xu, Caiyu Chen, Tianyang Xia, Qiao Liao, Yonggang Yao, Cindy Zeng, Duofen He, Yongjian Yang, Tao Tan, Jianxun Yi, Jingsong Zhou, Hua Zhu, Jianjie Ma, Chunyu Zeng
Limb remote ischemic preconditioning (RIPC) is an effective means of protection against ischemia/reperfusion (IR)-induced injury to multiple organs. Many studies are focused on identifying endocrine mechanisms that underlie the cross-talk between muscle and RIPC-mediated organ protection. We report that RIPC releases irisin, a myokine derived from the extracellular portion of fibronectin domain-containing 5 protein (FNDC5) in skeletal muscle, to protect against injury to the lung. Human patients with neonatal respiratory distress syndrome show reduced concentrations of irisin in the serum and increased irisin concentrations in the bronchoalveolar lavage fluid, suggesting transfer of irisin from circulation to the lung under physiologic stress...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29170426/non-invasive-whole-body-detection-of-complement-activation-using-radionuclide-imaging-in-a-mouse-model-of-myocardial-ischaemia-reperfusion-injury
#18
Ehsan Sharif-Paghaleh, May Lin Yap, Sarah-Lena Puhl, Adam Badar, Julia Baguña Torres, Krisanat Chuamsaamarkkee, Florian Kampmeier, Richard A Smith, James Clark, Philip J Blower, Steven Sacks, Gregory E Mullen
Complement activation is a recognised mediator of myocardial ischaemia-reperfusion-injury (IRI) and cardiomyocytes are a known source of complement proteins including the central component C3, whose activation products can mediate tissue inflammation, cell death and profibrotic signalling. We investigated the potential to detect and quantify the stable covalently bound product C3d by external body imaging, as a marker of complement activation in heart muscle in a murine model of myocardial IRI. We used single-photon-emission-computed-tomography (SPECT) in conjunction with99m Technecium-labelled recombinant complement receptor 2 (99m Tc-rCR2), which specifically detects C3d at the site of complement activation...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114952/age-related-microvascular-dysfunction-novel-insight-from-near-infrared-spectroscopy
#19
Ryan Rosenberry, Madison Munson, Susie Chung, T Jake Samuel, Jordan Patik, Wesley J Tucker, Mark J Haykowsky, Michael D Nelson
What is the central question of this study? Can near-infrared spectroscopy (NIRS)-derived post-occlusion tissue oxygen saturation recovery kinetics be used to study age-related impairments in microvascular function? What is the main finding and its importance? Using a previously established 5 min cuff occlusion protocol, we found that NIRS-derived indices of microvascular function were markedly reduced in elderly compared with young participants. However, when we controlled for the absolute level of vasodilatory stimulus and matched the tissue desaturation level between groups, we found similar responses in young and elderly participants...
February 1, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29096356/salvianolic-acid-a-attenuates-limb-ischemia-reperfusion-injury-in-skeletal-muscle-of-rats
#20
Yijia Xiang, Shiyong Ye, Changhong Cai, Junchong Chen, Xuyong Zhao, Ning Zhu, Chunlai Zeng
Ischemia and reperfusion(I/R) injury can cause complications in applying blood flow treatment for atherosclerosis occlusion syndrome. Platelet activation and inflammatory reaction play a role in the procession of I/R injury. This study was designed to investigate the effects of Salvianolic Acid A(SAA) on limb I/R injury via inhibition of platelet activation and inflammatory reaction. Rats were divided into sham, I/R, I/R+SAA-Low (5mg/kg) and I/R+SAA-high (10mg/kg) groups with a procession of 6h for ischemia and 24h for reperfusion in the femoral artery of the right hind limb, with the exception of the sham group...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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