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Skeletal muscle reperfusion

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https://www.readbyqxmd.com/read/29187642/irisin-protects-mitochondria-function-during-pulmonary-ischemia-reperfusion-injury
#1
Ken Chen, Zaicheng Xu, Yukai Liu, Zhen Wang, Yu Li, Xuefei Xu, Caiyu Chen, Tianyang Xia, Qiao Liao, Yonggang Yao, Cindy Zeng, Duofen He, Yongjian Yang, Tao Tan, Jianxun Yi, Jingsong Zhou, Hua Zhu, Jianjie Ma, Chunyu Zeng
Limb remote ischemic preconditioning (RIPC) is an effective means of protection against ischemia/reperfusion (IR)-induced injury to multiple organs. Many studies are focused on identifying endocrine mechanisms that underlie the cross-talk between muscle and RIPC-mediated organ protection. We report that RIPC releases irisin, a myokine derived from the extracellular portion of fibronectin domain-containing 5 protein (FNDC5) in skeletal muscle, to protect against injury to the lung. Human patients with neonatal respiratory distress syndrome show reduced concentrations of irisin in the serum and increased irisin concentrations in the bronchoalveolar lavage fluid, suggesting transfer of irisin from circulation to the lung under physiologic stress...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29170426/non-invasive-whole-body-detection-of-complement-activation-using-radionuclide-imaging-in-a-mouse-model-of-myocardial-ischaemia-reperfusion-injury
#2
Ehsan Sharif-Paghaleh, May Lin Yap, Sarah-Lena Puhl, Adam Badar, Julia Baguña Torres, Krisanat Chuamsaamarkkee, Florian Kampmeier, Richard A Smith, James Clark, Philip J Blower, Steven Sacks, Gregory E Mullen
Complement activation is a recognised mediator of myocardial ischaemia-reperfusion-injury (IRI) and cardiomyocytes are a known source of complement proteins including the central component C3, whose activation products can mediate tissue inflammation, cell death and profibrotic signalling. We investigated the potential to detect and quantify the stable covalently bound product C3d by external body imaging, as a marker of complement activation in heart muscle in a murine model of myocardial IRI. We used single-photon-emission-computed-tomography (SPECT) in conjunction with (99m)Technecium-labelled recombinant complement receptor 2 ((99m)Tc-rCR2), which specifically detects C3d at the site of complement activation...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114952/age-related-microvascular-dysfunction-novel-insight-from-near-infrared-spectroscopy
#3
Ryan Rosenberry, Madison Munson, Susie Chung, T Jake Samuel, Jordan Patik, Wesley J Tucker, Mark J Haykowsky, Michael D Nelson
Near-infrared spectroscopy (NIRS) has emerged as a promising tool to evaluate vascular reactivity in vivo. Whether this approach can be used to assess age-related impairments in microvascular function has not been tested. Tissue oxygen saturation (StO2 ) post-occlusion recovery kinetics were measured in two distinct age groups (<35 year and >65 years) using NIRS placed over the flexor digitorum profundus. Key end-points included: (1) the desaturation rate during cuff occlusion; (2) the lowest StO2  value obtained during ischemia (StO2min ); (3) StO2  reperfusion rate; (4) the highest StO2  value reached after cuff release (StO2max ); and (5) the reactive hyperemia area under the curve (AUC)...
November 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29096356/salvianolic-acid-a-attenuates-limb-ischemia-reperfusion-injury-in-skeletal-muscle-of-rats
#4
Yijia Xiang, Shiyong Ye, Changhong Cai, Junchong Chen, Xuyong Zhao, Ning Zhu, Chunlai Zeng
Ischemia and reperfusion(I/R) injury can cause complications in applying blood flow treatment for atherosclerosis occlusion syndrome. Platelet activation and inflammatory reaction play a role in the procession of I/R injury. This study was designed to investigate the effects of Salvianolic Acid A(SAA) on limb I/R injury via inhibition of platelet activation and inflammatory reaction. Rats were divided into sham, I/R, I/R+SAA-Low (5mg/kg) and I/R+SAA-high (10mg/kg) groups with a procession of 6h for ischemia and 24h for reperfusion in the femoral artery of the right hind limb, with the exception of the sham group...
October 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29071437/effect-of-long-term-remote-ischemic-conditioning-in-patients-with-chronic-ischemic-heart-failure
#5
Kasper Pryds, Roni Ranghøj Nielsen, Anders Jorsal, Mona Sahlholdt Hansen, Steffen Ringgaard, Jens Refsgaard, Won Yong Kim, Annemette Krintel Petersen, Hans Erik Bøtker, Michael Rahbek Schmidt
Remote ischemic conditioning (RIC) protects against acute ischemia-reperfusion injury and may also have beneficial effects in patients with stable cardiovascular disease. We investigated the effect of long-term RIC treatment in patients with chronic ischaemic heart failure (CIHF). In a parallel group study, 22 patients with compensated CIHF and 21 matched control subjects without heart failure or ischemic heart disease were evaluated by cardiac magnetic resonance imaging, cardiopulmonary exercise testing, skeletal muscle function testing, blood pressure measurement and blood sampling before and after 28 ± 4 days of once daily RIC treatment...
October 25, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29065414/protective-effects-of-sonic-hedgehog-against-ischemia-reperfusion-injury-in-mouse-skeletal-muscle-via-akt-mtor-p70s6k-signaling
#6
Qiu Zeng, Qining Fu, Xuehu Wang, Yu Zhao, Hong Liu, Zhui Li, Fenghe Li
BACKGROUND/AIMS: Skeletal muscle ischemia/reperfusion (I/R) injury is a common and severe disease. Sonic hedgehog (Shh) plays a critical role in post-natal skeletal muscle regeneration. In the present study, the role of Shh in skeletal muscle I/R injury and the mechanisms involved were investigated. METHODS: The expression of Shh, AKT/mTOR/p70S6K and apoptosis pathway components were evaluated following tourniquet-induced skeletal muscle I/R injury. Then, mice were subjected to systemic administration of cyclopamine or one-shot treatment of a plasmid encoding the human Shh gene (phShh) to examine the effects of Shh on I/R injury...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29062662/hyperbaric-oxygen-inhibits-reperfusion-induced-neutrophil-polarization-and-adhesion-via-plasmin-mediated-vegf-release
#7
Ashish Francis, Shawna R Kleban, Linda L Stephenson, Patrick S Murphy, Peter R Letourneau, Xin-Hua Fang, Wei Z Wang, Richard C Baynosa
BACKGROUND: Ischemia-reperfusion (IR) injury is seen in many settings such as free flap salvage and limb replantation/revascularization. The consequences-partial/total flap loss, functional muscle loss, or amputation-can be devastating. Of the treatment options available for IR injury, hyperbaric oxygen (HBO) is the most beneficial. HBO inhibits neutrophil-endothelial adhesion through interference of CD18 neutrophil polarization in IR, a process mediated by nitric oxide. The purposes of this study were to examine the involvement of vascular endothelial growth factor (VEGF) in the beneficial HBO effect on CD18 polarization and neutrophil adhesion and investigate the effect of plasmin on VEGF expression in skeletal muscle following IR injury...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29038351/differences-in-oxidative-metabolism-modulation-induced-by-ischemia-reperfusion-between-trained-and-untrained-individuals-assessed-by-nirs
#8
Rogério N Soares, Kaitlin M McLay, Mitchell A George, Juan M Murias
Endurance training is associated with skeletal muscle adaptations that regulate the oxidative metabolism during ischemia/reperfusion. The aim of this study was to noninvasively assess in vivo differences in the oxidative metabolism activity during ischemia/reperfusion between trained and untrained individuals, using near infrared spectroscopy (NIRS) combined with a vascular occlusion test (VOT) technique (NIRS-VOT). Sixteen untrained (26.3 ± 5.1 year) and seventeen trained (29.4 ± 4.9 year) healthy young adult men were submitted to a VOT (2 min baseline, 5 min occlusion, and 8 min reperfusion)...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29021167/high-density-lipoprotein-delivered-after-myocardial-infarction-increases-cardiac-glucose-uptake-and-function-in-mice
#9
Sarah E Heywood, Adele L Richart, Darren C Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E Hagemeyer, Mark A Febbraio, Andrew L Siebel, Bronwyn A Kingwell
Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A potential strategy is to target cardiac glucose metabolism at the early stages after ischemia when glycolysis is critical for myocyte survival. Building on our discovery that high-density lipoprotein (HDL) modulates skeletal muscle glucose metabolism, we now demonstrate that a single dose of reconstituted HDL (rHDL) delivered after myocardial ischemia increases cardiac glucose uptake, reduces infarct size, and improves cardiac remodeling in association with enhanced functional recovery in mice...
October 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28912521/advanced-glycation-end-product-age-albumin-from-activated-macrophage-is-critical-in-human-mesenchymal-stem-cells-survival-and-post-ischemic-reperfusion-injury
#10
Myeongjoo Son, Woong Chol Kang, Seyeon Oh, Delger Bayarsaikhan, Hyosang Ahn, Jaesuk Lee, Hyunjin Park, Sojung Lee, Junwon Choi, Hye Sun Lee, Phillip C Yang, Kyunghee Byun, Bonghee Lee
Post-ischemic reperfusion injury (PIRI) triggers an intense inflammatory response which is essential for repair but is also implicated in pathogenesis of post-ischemic remodeling in several organs in human. Stem cell therapy has recently emerged as a promising method for treatment of PIRI in human. However, satisfactory results have not been reported due to severe loss of injected stem cells in PIRI including critical limb ischemia (CLI). For investigating the advanced glycation end-product-albumin (AGE-albumin) from activated macrophages is critical in both muscle cell and stem cell death, we evaluated the recovery of PIRI-CLI by injection of human bone marrow derived mesenchymal stem cells (hBD-MSCs) with or without soluble receptor for AGEs (sRAGE)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856161/the-protective-effects-of-fasciotomy-on-reperfusion-injury-of-skeletal-muscle-of-rabbits
#11
Rui-Hua Li, Jin Li, Shi-Lian Kan, Xi-Nan Zhang
The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28796258/loss-of-phd3-in-myeloid-cells-dampens-the-inflammatory-response-and-fibrosis-after-hind-limb-ischemia
#12
Angelika Beneke, Annemarie Guentsch, Annette Hillemann, Anke Zieseniss, Lija Swain, Dörthe M Katschinski
Macrophages are essential for the inflammatory response after an ischemic insult and thereby influence tissue recovery. For the oxygen sensing prolyl-4-hydroxylase domain enzyme (PHD) 2 a clear impact on the macrophage-mediated arteriogenic response after hind-limb ischemia has been demonstrated previously, which involves fine tuning a M2-like macrophage population. To analyze the role of PHD3 in macrophages, we performed hind-limb ischemia (ligation and excision of the femoral artery) in myeloid-specific PHD3 knockout mice (PHD3(-/-)) and analyzed the inflammatory cell invasion, reperfusion recovery and fibrosis in the ischemic muscle post-surgery...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28766352/effect-of-different-doses-of-pregabalin-on-skeletal-muscle-ischaemia-reperfusion-injury-in-rats
#13
L Ozturk, H T Dogan, A Kilicarslan, M E Aydin, A Ozer, H Demirtas, Y Kilic, E Iriz, A Kucuk, A C Bayraktar, M Kavutcu, M Arslan
AIM/INTRODUCTION: Analgesic, anti-inflammatory and anti-apoptotic effects of pregabalin have been shown previously. In this study, we investigated the protective effect of different doses of pregabalin on skeletal muscle IR injury in rats. MATERIALS AND METHODS: 24 rats were randomly divided into 4 groups (Control, Ischaemia-Reperfusion (IR), IR-Pregabalin 50 mg, IR-Pregabalin 200 mg). Following IR, serum Ischemia Modified Albumin (IMA) and tissue Paraoxonase (PON) were studied and gastrocnemius muscle tissue was removed for histopathologic examination...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28723729/wnt-signaling-in-cardiovascular-disease-opportunities-and-challenges
#14
Austin Gay, Dwight A Towler
PURPOSE OF REVIEW: Cardiometabolic diseases increasingly afflict our aging, dysmetabolic population. Complex signals regulating low-density lipoprotein receptor-related protein (LRP) and frizzled protein family members - the plasma membrane receptors for the cadre of Wnt polypeptide morphogens - contribute to the control of cardiovascular homeostasis. RECENT FINDINGS: Both canonical (β-catenin-dependent) and noncanonical (β-catenin-independent) Wnt signaling programs control vascular smooth muscle (VSM) cell phenotypic modulation in cardiometabolic disease...
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28721011/effect-of-picroside-ii-on-hind-limb-ischemia-reperfusion-injury-in-rats
#15
Yiğit Kılıç, Abdullah Özer, Tolga Tatar, Mustafa Hakan Zor, Mehmet Kirişçi, Hakan Kartal, Ali Doğan Dursun, Deniz Billur, Mustafa Arslan, Ayşegül Küçük
INTRODUCTION: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28706944/schisandrin-b-prevents-hind-limb-from-ischemia-reperfusion-induced-oxidative-stress-and-inflammation-via-mapk-nf-%C3%AE%C2%BAb-pathways-in-rats
#16
Ning Zhu, Changhong Cai, Aiming Zhou, Xuyong Zhao, Yijia Xiang, Chunlai Zeng
Schisandrin B (ScB), isolated from Schisandra chinensis (S. chinensis), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it is unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, ScB (20 mg/kg, 40 mg/kg, and 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery. After 6 h ischemia and 24 h reperfusion of left hind limb, ScB reduced I/R induced histological changes and edema...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28678794/ammonium-tetrathiomolybdate-following-ischemia-reperfusion-injury-chemistry-pharmacology-and-impact-of-a-new-class-of-sulfide-donor-in-preclinical-injury-models
#17
Alex Dyson, Felipe Dal-Pizzol, Giovanni Sabbatini, Anna B Lach, Federica Galfo, Juliano Dos Santos Cardoso, Bruna Pescador Mendonça, Iain Hargreaves, Bernardo Bollen Pinto, Daniel I Bromage, John F Martin, Kevin P Moore, Martin Feelisch, Mervyn Singer
BACKGROUND: Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS production. Ammonium tetrathiomolybdate (ATTM), a copper chelator, releases sulfide in a controlled and novel manner, and may offer potential therapeutic utility. METHODS AND FINDINGS: In vitro, ATTM releases sulfide in a time-, pH-, temperature-, and thiol-dependent manner...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28618761/the-effects-of-iloprost-and-alprostadil-on-ischemia-reperfusion-injury-in-preventing-inflammation-tissue-degeneration-and-apoptosis-in-rat-skeletal-muscle
#18
Elif Güneysu, Atacan Emre Koçman, Orhan Özatik, Cengiz Ovali, Betül Can, İbrahim Özkan Alataş, Mustafa Behçet Sevin
BACKGROUND/AIM: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury. MATERIALS AND METHODS: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28572498/edward-f-adolph-distinguished-lecture-exercise-teaching-myocytes-new-tricks
#19
Scott K Powers
Endurance exercise training promotes numerous cellular adaptations in both cardiac myocytes and skeletal muscle fibers. For example, exercise training fosters changes in mitochondrial dynamics including increased mitochondrial biogenesis and accelerated mitochondrial turnover. Additionally, endurance exercise training alters the abundance of numerous cytosolic and mitochondrial proteins in both cardiac and skeletal muscle myocytes, resulting in a protective phenotype in the active fibers; this exercise-induced protection of cardiac and skeletal muscle fibers is often referred to as "exercise preconditioning...
June 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28553782/coenzyme-q10-protects-skeletal-muscle-from-ischemia-reperfusion-through-the-nf-kappa-b-pathway
#20
Mandana Beigi Boroujeni, Zahra Khanipour Khayat, Khatereh Anbari, Ali Niapour, Mohammadreza Gholami, Anneh Mohammad Gharravi
OBJECTIVE: Coenzyme Q10 (CoQ10) has antioxidant and anti-inflammatory activity. The aim of this study was to investigate the effects of CoQ10 on the inhibition of nuclear factor-kappa B (NF-κB) activation during ischemia-reperfusion (I/R) of skeletal muscle. METHODS: For ischemia induction, the animals were anesthetized and the external iliac vessels blocked for three hours. CoQ10 or vehicle was given intraperitoneally during ischemia, just before reperfusion. Four groups received 3,7,14 and 28 days' reperfusion, respectively, after the intraperitoneal injection of CoQ10 and four corresponding groups received vehicle only...
July 2017: Perfusion
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