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Skeletal muscle reperfusion

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https://www.readbyqxmd.com/read/29891768/long-non-coding-rna-malat1-regulates-angiogenesis-in-hindlimb-ischemia
#1
Xuejing Zhang, Xuelian Tang, Milton H Hamblin, Ke-Jie Yin
Angiogenesis is a complex process that depends on the delicate regulation of gene expression. Dysregulation of transcription during angiogenesis often leads to various human diseases. Emerging evidence has recently begun to show that long non-coding RNAs (lncRNAs) may mediate angiogenesis in both physiological and pathological conditions; concurrently, underlying molecular mechanisms are largely unexplored. Previously, our lab identified metastasis associates lung adenocarcinoma transcript 1 ( Malat1 ) as an oxygen-glucose deprivation (OGD)-responsive endothelial lncRNA...
June 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29872405/diabetes-worsens-skeletal-muscle-mitochondrial-function-oxidative-stress-and-apoptosis-after-lower-limb-ischemia-reperfusion-implication-of-the-risk-and-safe-pathways
#2
Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Alain Meyer, Mervyn Singer, Valerie Wolff, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny
Objectives: Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-induced muscle dysfunction and the involvement of endogenous protective kinases in this process. Materials and Methods: Streptozotocin-induced diabetic and non-diabetic rats were randomized to control or to IR injury (3 h of aortic cross-clamping and 2 h of reperfusion). Mitochondrial respiration, reactive oxygen species (ROS) production, protein levels of superoxide dismutase (SOD2) and endogenous protective kinases (RISK and SAFE pathways) were investigated in rat gastrocnemius, together with upstream (GSK-3β) and downstream (cleaved caspase-3) effectors of apoptosis...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29867526/enhanced-local-skeletal-muscle-oxidative-capacity-and-microvascular-blood-flow-following-7-day-ischemic-preconditioning-in-healthy-humans
#3
Owen Jeffries, Mark Waldron, John R Pattison, Stephen D Patterson
Ischemic preconditioning (IPC), which involves intermittent periods of ischemia followed by reperfusion, is an effective clinical intervention that reduces the risk of myocardial injury and confers ischemic tolerance to skeletal muscle. Repeated bouts of IPC have been shown to stimulate long-term changes vascular function, however, it is unclear what metabolic adaptations may occur locally in the muscle. Therefore, we investigated 7 days of bilateral lower limb IPC (4 × 5 min) above limb occlusion pressure (220 mmHg; n = 10), or sham (20 mmHg; n = 10), on local muscle oxidative capacity and microvascular blood flow...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29847535/lower-extremity-cooling-reduces-ischemia-reperfusion-injury-following-zone-3-reboa-in-a-porcine-hemorrhage-model
#4
Meryl A Simon, Emily M Tibbits, Guillaume L Hoareau, Anders J Davidson, Erik S DeSoucy, E Robert Faulconer, J Kevin Grayson, Lucas P Neff, M Austin Johnson, Timothy K Williams
BACKGROUND: New strategies to mitigate ischemia during REBOA and to prolong its maximal duration are needed. We hypothesized that simple external cooling of the hind limbs would decrease ischemia-reperfusion injury following prolonged Zone 3 REBOA. METHODS: 12 swine were anesthetized, instrumented, splenectomized then underwent 15% total blood volume hemorrhage. Animals were randomized to hypothermia or control followed by 4 hours of Zone 3 REBOA, resuscitation with shed blood, and 3 hours of critical care...
May 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29786827/the-protective-effect-of-montelukast-against-skeletal-muscle-ischemia-reperfusion-injury-an-experimental-rat-model
#5
Mehmet İlker Bilgiç, Güray Altun, Hüsamettin Çakıcı, Kaan Gideroğlu, Gürsel Saka
BACKGROUND: Montelukast is a selective leukotriene D-4 receptor antagonist, which specifically and reversibly inhibits cysteinyl leukotriene-1 receptor. The aim of this study was to investigate the protective effect of Montelukast on skeletal muscle reperfusion injury created as acute ischemia-reperfusion (IR) injury in Wistar-albino rats. METHODS: The study comprised 16 male Wistar-albino rats. The rats were randomly separated into two groups as control (IR) and treatment (IR+Montelukast)...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29759300/decreased-contractile-response-of-peripheral-arterioles-to-serotonin-after-cpb-in-patients-with-diabetes
#6
Sharif A Sabe, Jun Feng, Yuhong Liu, Laura A Scrimgeour, Afshin Ehsan, Frank W Sellke
BACKGROUND: Regulation of coronary vasomotor tone by serotonin is significantly changed after cardioplegic arrest and reperfusion. The current study investigates whether cardiopulmonary bypass may also affect peripheral arteriolar response to serotonin in patients with or without diabetes. METHODS: Human peripheral microvessels (90-180 µm diameter) were dissected from harvested skeletal muscle tissues from diabetic and non-diabetic patients before and after cardiopulmonary bypass and cardiac surgery (n = 8/group)...
May 11, 2018: Surgery
https://www.readbyqxmd.com/read/29699865/color-coded-digital-subtraction-angiography-for-assessing-acute-skeletal-muscle-ischemia-reperfusion-injury-in-a-rabbit-model
#7
Yan Zhang, Chengzhi Li, Hong Zhang, Wanghai Li, Jinwei Li, Xiaobai Wang
RATIONALE AND OBJECTIVES: This paper describes an ongoing investigation of imaging and characterization of ischemia-reperfusion (IR) and investigated the use of color-coded digital subtraction angiography (DSA) to assess reperfusion injury or potential injury. METHODS: New Zealand white rabbits were subjected to right hindlimb ischemia (IR, n = 24) or sham operation (control, n = 6). After 3 hours, the IR rabbits underwent reperfusion and were assessed at 0, 6, 12, or 24 hours (n = 6 each)...
April 23, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29660904/ryanodine-receptor-antagonism-alleviates-skeletal-muscle-ischemia-reperfusion-injury-by-modulating-tnf-%C3%AE-and-il-10
#8
Hai-Peng Lin, Yan-Qing Zheng, Zhi-Ping Zhou, Gao-Xiong Wang, Ping-Fan Guo
BACKGROUND: Intracellular calcium overload has been implicated in various pathological conditions including ischemia reperfusion injury. This study aims to explore the effect and probable mechanism of dantrolene, a ryanodine receptor and intracellular calcium antagonist, on the skeletal muscle ischemia reperfusion injury. MATERIALS AND METHODS: SD rats were randomly divided into three groups: sham group which underwent anaesthesia and exposure of femoral vein, reperfusion group that received 2 h ischemia and the amount of diluent via femoral vein before 4 h reperfusion, dantrolene group that underwent 2 h ischemia and was given 2 mg/kg dantrolene via femoral vein before 4 h reperfusion...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29615933/dexamethasone-protects-against-tourniquet-induced-acute-ischemia-reperfusion-injury-in-mouse-hindlimb
#9
Ryan M Corrick, Huiyin Tu, Dongze Zhang, Aaron N Barksdale, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexamethasone, an anti-inflammatory drug, on tourniquet-induced acute IR injury in mouse hindlimb...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29602289/effect-of-iloprost-on-contractile-impairment-and-mitochondrial-degeneration-in-ischemia-reperfusion-of-skeletal-muscle
#10
Z Bagis, M Ozeren, B Buyukakilli, E Balli, S Yaman, D Yetkin, D Ovla
Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model. Main Methods Forty Wistar albino rats were randomly divided into a control group and four experimental groups...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29515706/pretreatment-with-the-free-radical-scavenger-edaravone-mitigates-kidney-glycogen-depletion-and-neutrophil-infiltration-after-leg-ischemia-in-a-rat-model-a-pilot-study
#11
Mitsuhiro Yamamura, Yuji Miyamoto, Masataka Mitsuno, Hiroe Tanaka, Masaaki Ryomoto
Objective : We have previously shown that pretreatment with the free radical scavenger edaravone (Radicut® , Mitsubishi Tanabe Pharma Co., Japan) mitigated skeletal muscle damage due to ischemia reperfusion. In this study, we sought to validate its use in an experimental model of myonephropathic-metabolic syndrome (MNMS). Methods : Either edaravone (3.0 mg/kg; edaravone group; n=4) or saline (saline group; n=6) was intraperitoneally injected into male Lewis rats (508±31 g). Normal kidneys were harvested as control (n=3)...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29512311/nitrite-as-a-pharmacological-intervention-for-the-successful-treatment-of-crush-syndrome
#12
REVIEW
Jun Kobayashi, Isamu Murata
Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen species and subsequent systemic inflammation. Therefore, ischemic pre and postconditioning are performed in clinical practice. Intravenous administration of nitrite inhibits IRI through nitric oxide-mediated mechanisms...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29498531/clinical-translation-of-myocardial-conditioning
#13
Hans Erik Botker, Thomas Ravn Lassen, Nichlas Riise Jespersen
Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy have improved outcome in patients with ST-elevation myocardial infarction. The next major target to further improve outcome, seems to be ischemia reperfusion injury, which may contribute significantly to the final infarct size and hence mortality and post-infarction heart failure. Mechanical conditioning strategies including local and remote ischemic pre-, per- and postconditioning have demonstrated consistent cardioprotective capacities in experimental models of acute IR injury...
March 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29488785/highs-and-lows-of-hyperoxia-physiological-performance-and-clinical-aspects
#14
Julien Vincent Brugniaux, Geoff B Coombs, Otto F Barak, Zeljko Dujic, Mypinder S Sekhon, Philip N Ainslie
Molecular oxygen (O2 ) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content (CaO2 ), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Nevertheless, with various degrees of effectiveness, and not without consequences, supplemental oxygen is used clinically in an attempt to correct tissue hypoxia (e...
February 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29487339/ablation-of-bax-and-bak-protects-skeletal-muscle-against-pressure-induced-injury
#15
Bjorn T Tam, Angus P Yu, Eric W Tam, Douglas A Monks, Xu P Wang, Xiao M Pei, Su P Koh, Thomas K Sin, Helen K W Law, Felix N Ugwu, Rashmi Supriya, Benjamin Y Yung, Shea P Yip, S C Wong, Lawrence W Chan, Christopher W Lai, Pin Ouyang, Parco M Siu
Pressure-induced injury (PI), such as a pressure ulcer, in patients with limited mobility is a healthcare issue worldwide. PI is an injury to skin and its underlying tissue such as skeletal muscle. Muscle compression, composed of mechanical deformation of muscle and external load, leads to localized ischemia and subsequent unloading reperfusion and, hence, a pressure ulcer in bed-bound patients. Although the gross factors involved in PI have been identified, little is known about the exact disease mechanism or its links to apoptosis, autophagy and inflammation...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432799/mitochondrial-protein-s-nitrosation-protects-against-ischemia-reperfusion-induced-denervation-at-neuromuscular-junction-in-skeletal-muscle
#16
Rebecca J Wilson, Joshua C Drake, Di Cui, Bevan M Lewellen, Carleigh C Fisher, Mei Zhang, David F Kashatus, Lisa A Palmer, Michael P Murphy, Zhen Yan
Deterioration of neuromuscular junction (NMJ) integrity and function is causal to muscle atrophy and frailty, ultimately hindering quality of life and increasing the risk of death. In particular, NMJ is vulnerable to ischemia reperfusion (IR) injury when blood flow is restricted followed by restoration. However, little is known about the underlying mechanism(s) and hence the lack of effective interventions. New evidence suggests that mitochondrial oxidative stress plays a causal role in IR injury, which can be precluded by enhancing mitochondrial protein S-nitrosation (SNO)...
March 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29425473/beetroot-increases-muscle-performance-and-oxygenation-during-sustained-isometric-exercise-but-does-not-alter-muscle-oxidative-efficiency-and-microvascular-reactivity-at-rest
#17
Stavros Papadopoulos, Konstantina Dipla, Areti Triantafyllou, Michalis G Nikolaidis, Antonios Kyparos, Panagiota Touplikioti, Ioannis S Vrabas, Andreas Zafeiridis
OBJECTIVE: To examine the effects of beetroot juice (BRJ) on (i) in vivo skeletal muscle O2 consumption (mVO2 ) and microvascular reactivity at rest and (ii) muscle performance, muscle oxygenation, and mVO2 during sustained isometric handgrip exercise (IHG). METHODS: Sixteen young males consumed, randomly, a nitrate-rich (8.1 mmol BRJnitrate) or nitrate-depleted (BRJplacebo) BRJ. After 2.5 hours, they performed an occlusion-reperfusion maneuver at rest, a 3-minute sustained IHG, and a sustained IHG to exhaustion with arterial occlusion...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29395744/tourniquet-time-in-total-knee-arthroplasty
#18
Lasse E Rasmussen, Henriette A Holm, Per W Kristensen, Per Kjaersgaard-Andersen
BACKGROUND: Whether the arterial tourniquet in total knee arthroplasty (TKA) is a friend or a foe is still debated. Longer ischemia causes hypoxic damage; yet short duration of a tourniquet may influence outcome. Understanding the time-dependent influence of the tourniquet in TKA patients could improve the overall outcome and safety. The purpose of the study was to measure the tourniquet-induced time-dependent alterations in skeletal muscle metabolism in TKA to establish a 'safe tourniquet time...
March 2018: Knee
https://www.readbyqxmd.com/read/29385043/interplay-between-ros-and-antioxidants-during-ischemia-reperfusion-injuries-in-cardiac-and-skeletal-muscle
#19
REVIEW
Tingyang Zhou, Evan R Prather, Davis E Garrison, Li Zuo
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29384781/systemic-administration-of-carbon-monoxide-releasing-molecule-3-protects-the-skeletal-muscle-in-porcine-model-of-compartment-syndrome
#20
Aurelia Bihari, Gediminas Cepinskas, David Sanders, Abdel-Rahman Lawendy
OBJECTIVES: Acute limb compartment syndrome, a complication of musculoskeletal trauma, results in muscle necrosis and cell death. Carbon monoxide, liberated from the carbon monoxide-releasing molecule-3, has been shown protective in a rat model of compartment syndrome. The purpose of this study was to test the effect of carbon monoxide-releasing molecule-3 in a preclinical large animal model of compartment syndrome, with the ultimate goal of developing a pharmacologic adjunct treatment for compartment syndrome...
May 2018: Critical Care Medicine
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