Taotao Zhou, Xibin Wang, Kaitao Wang, Yi Lin, Zhefeng Meng, Qicheng Lan, Zhikai Jiang, Jianpeng Chen, Yuting Lin, Xuao Liu, Hang Lin, Shijie Wu, Dingsheng Lin
OBJECTIVE: Random skin flaps have many applications in plastic and reconstructive surgeries. However, distal flap necrosis restricts wider clinical utility. Mitophagy, a vital form of autophagy for damaged mitochondria, is excessively activated in flap ischemia/reperfusion (I/R) injury, thus inducing cell death. Aldehyde dehydrogenase-2 (ALDH2), an allosteric tetrameric enzyme, plays an important role in regulating mitophagy. We explored whether ALDH2 activated by N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1) could reduce the risk of ischemic random skin flap necrosis, and the possible mechanism of action...
2023: Frontiers in Immunology