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Nayana Damiani Macedo, Aline Rodrigues Buzin, Isabela Bastos Binotti Abreu de Araujo, Breno Valentim Nogueira, Tadeu Uggere de Andrade, Denise Coutinho Endringer, Dominik Lenz
OBJECTIVE: The current study proposes an automated machine learning approach for the quantification of cells in cell death pathways according to DNA fragmentation. METHODS: A total of 17 images of kidney histological slide samples from male Wistar rats were used. The slides were photographed using an Axio Zeiss Vert.A1 microscope with a 40x objective lens coupled with an Axio Cam MRC Zeiss camera and Zen 2012 software. The images were analyzed using CellProfiler (version 2...
December 28, 2016: Tissue & Cell
Olga Sergeevna Shubina, Natalia Anatolievna Dudenkova
AIM: The aim of this study was to investigate the morphological and functional features of the process of spermatogenesis in the testes of male albino rats when exposed to lead acetate. MATERIALS AND METHODS: Using histological, morphometric and statistical methods explored the effects of lead acetate on the process of spermatogenesis in the testes of male albino rats. Investigations were carried out using a digital microscope Axio Imager. M2 and automatic cell counter Countess™...
October 2016: Veterinary World
Lorena Oliveira Pedroche, Sérgio Rocha Bernardes, Moira Pedroso Leão, Cibele Cândida de Almeida Kintopp, Gisele Maria Correr, Bárbara Pick Ornaghi, Carla Castiglia Gonzaga
The objective of this study was to evaluate the marginal and internal fit of zirconia copings obtained with different digital scanning methods. A human mandibular first molar was set in a typodont with its adjacent and antagonist teeth and prepared for an all-ceramic crown. Digital impressions were made using an intraoral scanner (3Shape). Polyvinyl siloxane impressions and Type IV gypsum models were also obtained and scanned with a benchtop laboratory scanner (3Shape D700). Ten zirconia copings were fabricated for each group using CAD-CAM technology...
October 10, 2016: Brazilian Oral Research
Eduardo Rodrigues-Pinto, Todd H Baron
INTRODUCTION: Endoscopic ultrasound guided translumenal drainage of pancreatic fluid collections (PFCs) has been widely practiced for over a decade, using conventional plastic and self-expandable metal stents. The use of such stents for transmural drainage is off-label and limited by the lack of lumen-to-lumen anchorage, which can lead to leakage, migration and tissue trauma. AREAS COVERED: Novel stent designs dedicated to applications of translumenal drainage have recently emerged and promise to make transmural drainage quicker, safer, and more effective...
September 2016: Expert Review of Medical Devices
Carmelo Barbera, Giuseppe Grande, Nadia Alberghina, Mauro Manno, Rita Luisa Conigliaro
No abstract text is available yet for this article.
2016: Endoscopy
George D Koufos, Louis de Bonis, Dimitris Kugiumtzis
New hominoid teeth from the late Miocene locality Ravin de la Pluie (RPl) of the Axios Valley (Macedonia, Greece) are studied in this article. Their morphology, dimensions and proportions are similar to the hominoid Ouranopithecus macedoniensis, allowing their attribution to this taxon. The studied material provides some new morphological characters for the female P3 (small asymmetry, small mesiobuccal crown projection, paracone higher than protocone) and the lower canine (mesial groove: large in the male and small in the female, distobuccal fovea: large in the female and small in the male)...
2016: Folia Primatologica; International Journal of Primatology
Reem Z Sharaiha, Amy Tyberg, Mouen A Khashab, Nikhil A Kumta, Kunal Karia, Jose Nieto, Uzma D Siddiqui, Irving Waxman, Virendra Joshi, Petros C Benias, Peter Darwin, Christopher J DiMaio, Christopher J Mulder, Shai Friedland, David G Forcione, Divyesh V Sejpal, Tamas A Gonda, Frank G Gress, Monica Gaidhane, Ann Koons, Ersilia M DeFilippis, Sanjay Salgado, Kristen R Weaver, John M Poneros, Amrita Sethi, Sammy Ho, Vivek Kumbhari, Vikesh K Singh, Alan H Tieu, Viviana Parra, Alisa Likhitsup, Craig Womeldorph, Brenna Casey, Sreeni S Jonnalagadda, Amit P Desai, David L Carr-Locke, Michel Kahaleh, Ali A Siddiqui
BACKGROUND & AIMS: Endoscopic ultrasound-guided transmural drainage and necrosectomy have become the standard treatment for patients with pancreatic walled-off necrosis (WON). Lumen-apposing metal stents (LAMS) have shown success in the management of pancreatic fluid collections. However, there are few data on their specific roles in management of WON. We investigated the efficacy and safety of LAMS in treatment of WON. METHODS: We performed a retrospective multicenter case series of 124 patients with WON who underwent endoscopic transmural drainage by using LAMS at 17 tertiary care centers from January 2014 through May 2015...
May 14, 2016: Clinical Gastroenterology and Hepatology
Jin-Young Park, Il-Do Jeong, Jae-Jun Lee, So-Yeon Bae, Ji-Hwan Kim, Woong-Chul Kim
STATEMENT OF PROBLEM: The fit of an interim implant restoration (IIR) is important for the effective treatment of patients with partial edentulism. However, no clinical trials have evaluated the marginal and internal fittings achieved with various fabrication methods. PURPOSE: The purpose of this in vitro study was to evaluate and compare the marginal and internal discrepancies in IIRs produced with 3 different methods. MATERIAL AND METHODS: Partially edentulous maxillary and mandibular casts from a transfer abutment were used...
October 2016: Journal of Prosthetic Dentistry
Rashmee Patil, Mel A Ona, Charilaos Papafragkakis, Sury Anand, Sushil Duddempudi
Pancreatic fluid collections (PFCs) have conventionally been treated with surgery, percutaneous drainage, or with the more recently established endoscopic ultrasound (EUS)-guided drainage modality. Currently, endoscopic plastic or metallic stents are used for PFC drainage. Plastic stents present issues with stent migration and premature occlusion requiring frequent stent exchanges or placement of additional stents. Metallic stents are tubular and may migrate, resulting in inefficient drainage, content leakage, retrieval and replacement, and possible mucosal injury...
April 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Ting-Shu Su, Jian Sun
STATEMENT OF PROBLEM: For 20 years, the intraoral digital impression technique has been applied to the fabrication of computer aided design and computer aided manufacturing (CAD-CAM) fixed dental prostheses (FDPs). Clinical fit is one of the main determinants of the success of an FDP. Studies of the clinical fit of 3-unit ceramic FDPs made by means of a conventional impression versus a digital impression technology are limited. PURPOSE: The purpose of this in vitro study was to evaluate and compare the internal fit and marginal fit of CAD-CAM, 3-unit ceramic FDP frameworks fabricated from an intraoral digital impression and a conventional impression...
September 2016: Journal of Prosthetic Dentistry
Rastislav Kunda, Manuel Pérez-Miranda, Uwe Will, Sebastian Ullrich, Dirk Brenke, Markus Dollhopf, Michelle Meier, Alberto Larghi
BACKGROUND: A novel lumen-apposing, self-expanding metal stent to perform EUS-guided drainage procedures has been recently developed. The aim of this study was to analyze the safety, technical and clinical effectiveness of this device for EUS-guided choledochoduodenostomy (EUS-CD) with palliative intent. METHODS: Retrospective analysis of all consecutive patients with unresectable malignant distal bile duct obstruction who, between March 2012 and September 2014, underwent EUS-CD using the study devices (AXIOS™ and Hot AXIOS™, Xlumena Inc...
March 11, 2016: Surgical Endoscopy
Ji Young Bang, Shyam Varadarajulu
No abstract text is available yet for this article.
January 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Felipe Martínez Alcalá, Felipe R Martínez-Alcalá García, Andres Sánchez-Yague, Alvaro Martínez-Alcalá García, Jose Antonio Ciria Avila, Jose Manuel Perez Pozo
No abstract text is available yet for this article.
2015: Endoscopy
Mikhail Buldakov, Marina Zavyalova, Nadezhda Krakhmal, Nadezhda Telegina, Sergei Vtorushin, Irina Mitrofanova, Vladimir Riabov, Shuiping Yin, Bin Song, Nadezhda Cherdyntseva, Julia Kzhyshkowska
Tumor associated macrophages (TAM) support tumor growth and metastasis in several animal models of breast cancer, and TAM amount is predictive for efficient tumor growth and metastatic spread via blood circulation. However, limited information is available about intratumoral TAM heterogeneity and functional role of TAM subpopulations in tumor progression. The aim of our study was to examine correlation of TAM presence in various morphological segments of human breast cancer with clinical parameters. Thirty six female patients with nonspecific invasive breast cancer T1-4N0-3M0 were included in the study...
January 2017: Immunobiology
Camilo Guzmán, Christina Oetken-Lindholm, Daniel Abankwa
Fluorescence resonance energy transfer (FRET) is widely used to study conformational changes of macromolecules and protein-protein, protein-nucleic acid, and protein-small molecule interactions. FRET biosensors can serve as valuable secondary assays in drug discovery and for target validation in mammalian cells. Fluorescence lifetime imaging microscopy (FLIM) allows precise quantification of the FRET efficiency in intact cells, as FLIM is independent of fluorophore concentration, detection efficiency, and fluorescence intensity...
April 2016: Journal of Laboratory Automation
Evangelos Vlachos, Ignacio Cerda, Evangelia Tsoukala
Soft-shelled turtles (Pan-Trionychidae) are not included in the present-day chelonian fauna of Greece and have been unknown in the Greek fossil record up to now. Here, we report the first fossil occurrence of a soft-shelled turtle from Greece, originating from the Pliocene Gefira Member (Angelochori Formation), in the lower Axios valley. The corresponding specimens were discovered with several mammalian remains, most of them attributable to the mastodon of Auvergne, Anancus arvernensis. The chelonian material includes five carapacial fragments that belong to the same individual and can be attributed to Pan-Trionychidae based on the typical sculpturing on the dorsal side of the carapace...
August 2015: Die Naturwissenschaften
Mario R Castellanos, Anita Szerszen, Stephen Gundry, Edyta C Pirog, Mitchell Maiman, Sritha Rajupet, John Paul Gomez, Adi Davidov, Priya Ranjan Debata, Probal Banerjee, Jimmie E Fata
BACKGROUND: Pathological classification of cervical intraepithelial neoplasia (CIN) is problematic as it relies on subjective criteria. We developed an imaging method that uses spectroscopy to assess the fluorescent intensity of cervical biopsies derived directly from hematoxylin and eosin (H&E) stained tissues. METHODS: Archived H&E slides were identified containing normal cervical tissue, CIN I, and CIN III cases, from a Community Hospital and an Academic Medical Center...
2015: Diagnostic Pathology
Henrik Holten-Rossing, Maj-Lis Møller Talman, Martin Kristensson, Ben Vainer
In breast cancer, analysis of HER2 expression is pivotal for treatment decision. This study aimed at comparing digital, automated image analysis with manual reading using the HER2-CONNECT algorithm (Visiopharm) in order to minimize the number of equivocal 2+ scores and the need for reflex fluorescence in situ hybridization (FISH) analysis. Consecutive samples from 462 patients were included. Tissue micro arrays (TMAs) were routinely manufactured including two 2 mm cores from each patient, and each core was assessed in order to ensure the presence of invasive carcinoma...
July 2015: Breast Cancer Research and Treatment
Danush Ahrberg, Hans Christoph Lauer, Martin Ahrberg, Paul Weigl
OBJECTIVES: The aim of this clinical trial was to evaluate the marginal and internal fit of CAD/CAM fabricated zirconia crowns and three-unit fixed dental prostheses (FDPs) resulting from direct versus indirect digitalization. The efficiency of both methods was analyzed. MATERIALS AND METHODS: In 25 patients, 17 single crowns and eight three-unit FDPs were fabricated with all-ceramic zirconia using CAD/CAM technology. Each patient underwent two different impression methods; a computer-aided impression with Lava C...
March 2016: Clinical Oral Investigations
Pedro Celso de Castro Pita, Flávia Cristina Morone Pinto, Mariana Montenegro de Melo Lira, Francisco de Assis Dutra Melo, Lydia Masako Ferreira, José Lamartine de Andrade Aguiar
PURPOSE: To evaluate the biocompatibility and local sensibility reaction to bacterial cellulose hydrogel (0.8%) implanted in subcutaneous tissue of rabbits. METHODS: Fifteen New Zeland rabbits were randomly allocated into three groups: T1, 7 days, T2, 21 days, and T3, 84 days. The new material was implanted in the subcutaneous tissue of the ear; on the scalp over the periosteum; and on the outer and inner surfaces of the thighs, in the aponeurosis of the muscle...
April 2015: Acta Cirúrgica Brasileira
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