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https://www.readbyqxmd.com/read/28732051/cd4-is-expressed-on-a-heterogeneous-subset-of-hematopoietic-progenitors-which-persistently-harbor-cxcr4-and-ccr5-tropic-hiv-proviral-genomes-in-vivo
#1
Nadia T Sebastian, Thomas D Zaikos, Valeri Terry, Frances Taschuk, Lucy A McNamara, Adewunmi Onafuwa-Nuga, Ryan Yucha, Robert A J Signer, James Riddell, Dale Bixby, Norman Markowitz, Sean J Morrison, Kathleen L Collins
Latent HIV infection of long-lived cells is a barrier to viral clearance. Hematopoietic stem and progenitor cells are a heterogeneous population of cells, some of which are long-lived. CXCR4-tropic HIVs infect a broad range of HSPC subtypes, including hematopoietic stem cells, which are multi-potent and long-lived. However, CCR5-tropic HIV infection is limited to more differentiated progenitor cells with life spans that are less well understood. Consistent with emerging data that restricted progenitor cells can be long-lived, we detected persistent HIV in restricted HSPC populations from optimally treated people...
July 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28730997/improving-the-electrical-contact-at-a-pt-tio2-nanowire-interface-by-selective-application-of-focused-femtosecond-laser-irradiation
#2
Songling Xing, Luchan Lin, Guisheng Zou, Lei Liu, Peng Peng, Aiping Wu, Walter W Duley, Norman Zhou
In this paper, we show that tightly focused femtosecond laser irradiation is effective in improving nanojoining of an oxide nanowire (TiO2) to a metal electrode (Pt), and how this process can be used to modify contact states. Enhanced chemical bondings are created due to localized plasmonically enhanced optical absorption at the Pt/TiO2 interface as confirmed by finite element simulations of the localized field distribution during irradiation. Nano Auger electron spectroscopy shows that the resulting heterojunction is depleted in oxygen, suggesting that a TiO2-x layer is formed between the Pt electrode and the TiO2 nanowire...
July 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28729954/clinical-streptococcal-isolates-distinct-from-streptococcus-pneumoniae-but-containing-the-%C3%AE-glucosyltransferase-tts-gene-and-expressing-serotype-37-capsular-polysaccharide
#3
Carmen L Sheppard, Georgia Kapatai, Karen Broughton, Ulf Schaefer, Matthew Hannah, David J Litt, Norman K Fry
The major virulence factor of the pneumococcus, and target for conjugate vaccines, is the polysaccharide capsule, which is usually encoded by the highly variable cps locus. Serotype 37 is an unusual pneumococcal type in which the single β-glucosyltransferase gene responsible for serotype capsule production (tts) is located outside of the capsular operon region. Using a previously described automated whole genome sequence (WGS)-based serotyping bioinformatics tool, PneumoCaT, we identified and investigated seven clinical isolates (three from blood cultures) of non-pneumococcal streptococci containing a highly homologous tts and included them in a study panel of 20 isolates which included a 11 further clinical isolates of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28728615/success-of-tonsillectomy-for-obstructive-sleep-apnea-in-children-with-down-syndrome
#4
David G Ingram, Amanda G Ruiz, Dexiang Gao, Norman R Friedman
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy. METHODS: A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had either a concurrent adenoidectomy or had previously underwent an adenoidectomy. Children with preoperative and postoperative polysomnograms within 6 months of surgery were included in the analysis...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28726833/human-occupation-of-northern-australia-by-65-000-years-ago
#5
Chris Clarkson, Zenobia Jacobs, Ben Marwick, Richard Fullagar, Lynley Wallis, Mike Smith, Richard G Roberts, Elspeth Hayes, Kelsey Lowe, Xavier Carah, S Anna Florin, Jessica McNeil, Delyth Cox, Lee J Arnold, Quan Hua, Jillian Huntley, Helen E A Brand, Tiina Manne, Andrew Fairbairn, James Shulmeister, Lindsey Lyle, Makiah Salinas, Mara Page, Kate Connell, Gayoung Park, Kasih Norman, Tessa Murphy, Colin Pardoe
The time of arrival of people in Australia is an unresolved question. It is relevant to debates about when modern humans first dispersed out of Africa and when their descendants incorporated genetic material from Neanderthals, Denisovans and possibly other hominins. Humans have also been implicated in the extinction of Australia's megafauna. Here we report the results of new excavations conducted at Madjedbebe, a rock shelter in northern Australia. Artefacts in primary depositional context are concentrated in three dense bands, with the stratigraphic integrity of the deposit demonstrated by artefact refits and by optical dating and other analyses of the sediments...
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28725867/revisiting-the-psychometric-properties-of-the-scoliosis-research-society-22-srs-22-french-version
#6
Jean Théroux, Norman Stomski, Stanley Innes, Ariane Ballard, Christelle Khadra, Hubert Labelle, Sylvie Le May
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is among the most common spinal deformities affecting adolescents. The Scoliosis Research Society-22 questionnaire is commonly used to assess health-related quality of life in AIS patients, including pain. The objective of this study is to verify the psychometric properties of the Scoliosis Research Society-22 French version (SRS-22fv) questionnaire. METHODS: A prospective methodological design was used to verify the psychometric properties of the French version of the SRS-22fv...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28725184/sevoflurane-induces-coherent-slow-delta-oscillations-in-rats
#7
Jennifer A Guidera, Norman E Taylor, Justin T Lee, Ksenia Y Vlasov, JunZhu Pei, Emily P Stephen, J Patrick Mayo, Emery N Brown, Ken Solt
Although general anesthetics are routinely administered to surgical patients to induce loss of consciousness, the mechanisms underlying anesthetic-induced unconsciousness are not fully understood. In rats, we characterized changes in the extradural EEG and intracranial local field potentials (LFPs) within the prefrontal cortex (PFC), parietal cortex (PC), and central thalamus (CT) in response to progressively higher doses of the inhaled anesthetic sevoflurane. During induction with a low dose of sevoflurane, beta/low gamma (12-40 Hz) power increased in the frontal EEG and PFC, PC and CT LFPs, and PFC-CT and PFC-PFC LFP beta/low gamma coherence increased...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28724990/large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#8
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephan Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichman, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28723473/can-decellularised-prostate-tissue-be-used-to-model-tumour-malignancy
#9
EDITORIAL
Norman J Maitland
This editorial discusses how feasible it will be to predict the invasive capacity of human prostate cancers by measuring their invasion into decellularised extracellular matrix and stresses the multiple factors that affect local metastasis, including immune and stromal cells.
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721890/the-prognostic-value-of-braf-c-kit-and-nras-mutations-in-melanoma-patients-with-brain-metastases
#10
Paul W Sperduto, Wen Jiang, Paul D Brown, Steve Braunstein, Penny Sneed, Daniel A Wattson, Helen A Shih, Ananta Bangdiwala, Ryan Shanley, Natalie A Lockney, Kathryn Beal, Emil Lou, Thomas Amatruda, William A Sperduto, John P Kirkpatrick, Norman Yeh, Laurie E Gaspar, Jason K Molitoris, Laura Masucci, David Roberge, James Yu, Veronica Chiang, Minesh Mehta
PURPOSE: Brain metastases are a common problem in patients with melanoma, but little is known about the effect of gene mutations on survival in these patients. METHODS AND MATERIALS: We created a retrospective multi-institutional database of 823 patients with melanoma and brain metastases diagnosed between 2006 and 2015. Clinical parameters, gene mutation status (BRAF, C-KIT, NRAS), and treatment were correlated with survival. Treatment patterns and outcomes were compared with a prior era (1985-2005)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721722/pillar-5-arene-based-supramolecular-plasmonic-thin-films-for-label-free-quantitative-and-multiplex-sers-detection
#11
Verónica Montes García, Borja Gómez-González, Diego M Solís, Jose M Taboada, Norman Jiménez Otero, Jacobo de Uña-Álvarez, Fernando Obelleiro, Luis García-Río, Jorge Perez-Juste, Isabel Pastoriza-Santos
Novel plasmonic thin films based on electrostatic layer-by-layer (LbL) deposition of citrate-stabilized Au nanoparticles (NPs) and ammonium pillar[5]arene (AP[5]A) has been developed. The supramolecular-induced LbL assembly of the plasmonic nanoparticles yields to the formation of controlled hot-spots with uniform interparticle distances. At the same time this strategy allows to modulate the density and dimensions of the Au aggregates, and therefore the optical response, on the thin film with the number of AuNP-AP[5]A deposition cycles...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721206/a-bipedal-mammalian-model-for-spinal-cord-injury-research-the-tammar-wallaby
#12
Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood
Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent functional results from such studies can be translated to bipedal species such as humans because bipedal and quadrupedal locomotion involve very different patterns of spinal control of muscle coordination. Bipedalism requires upright trunk stability and coordinated postural muscle control; it has been suggested that peripheral sensory input is less important in humans than quadrupeds for recovery of locomotion following spinal injury...
2017: F1000Research
https://www.readbyqxmd.com/read/28720919/delivering-tobacco-cessation-content-in-the-middle-east-through-interprofessional-learning
#13
Alla El-Awaisi, Ahmed Awaisu, Maguy Saffouh El Hajj, Bayan Alemrayat, Ghadir Al-Jayyousi, Norman Wong, Mohamud A Verjee
Objective. To explore the attitudes of pharmacy, pharmacy technician, medical, and public health students before and after an IPE activity that focused on smoking cessation in the Middle East. Methods. A pre-post intervention research design using the Readiness for Interprofessional Learning Scale (RIPLS) was used for this study. The tool contained 20 items, categorized under the following subscales: teamwork and collaboration, professional identity, and patient-centeredness. Results. A total of 47 out of 50 students from four different health disciplines in Qatar (medicine, pharmacy, pharmacy technician, and public health) who participated in the activity completed a pre- and post-intervention pre-validated questionnaire (94% response rate)...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28719320/skin-manifestations-of-primary-vibrio-vulnificus-septicemia
#14
Norman L Beatty, Jose Marquez, Mayar Al Mohajer
No abstract text is available yet for this article.
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719091/multimodal-analgesia-as-an-alternative-to-the-risks-of-opioid-monotherapy-in-surgical-pain-management
#15
John J Savarese, Norman G Tabler
Clinicians have long been aware of the danger of overreliance on opioids to manage acute pain, such as the pain accompanying surgery. The risk of adverse drug events is higher with opioids than with any other common class of drugs. Overreliance on opioids increases length of stay and hospital costs, while decreasing patient satisfaction. Opioids can lead to problems that continue well after discharge, including chronic pain, abuse and addiction, and even death. Increasingly, prescribed opioids have proved to lead to heroin addiction...
July 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28718639/regioselective-synthesis-nmr-and-crystallographic-analysis-of-n1-substituted-pyrazoles
#16
Adrian Huang, Kellie Wo, So Yeun Christine Lee, Nika Kneitschel, Jennifer Chang, Kathleen Zhu, Tatsiana Mello, Laura Bancroft, Natalie Norman, Shao-Liang Zheng
A systematic study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions has been undertaken. Regioselective N1-alkylation, -arylation, and -heteroarylation of 3-substituted pyrazoles have been achieved using K2CO3-DMSO. The regioseletivity is justified by the DFT calculations at the B3LYP/6-31G**(d) level. A consistent steric effect on chemical shift has been observed for N-alkyl pyrazole analogs. 25 X-ray crystallographic structures have been obtained to confirm the regiochemistry of the major products...
July 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28715350/a-prospective-multisite-international-validation-of-the-complex-regional-pain-syndrome-severity-score
#17
R Norman Harden, Christian Maihofner, Elias Abousaad, Jean-Jacques Vatine, Amy Kirsling, Roberto S G M Perez, Maxine Kuroda, Florian Brunner, Michael Stanton-Hicks, Johan Marinus, Jacobus J van Hilten, Sean Mackey, Frank Birklein, Tanja Schlereth, Angela Mailis-Gagnon, Joe Graciosa, Sara B Connoly, David Dayanim, Michael Massey, Hadas Frank, Anatoly Livshitz, Stephen Bruehl
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity...
August 2017: Pain
https://www.readbyqxmd.com/read/28710900/pre-kidney-transplant-lower-extremity-impairment-and-post-transplant-mortality
#18
Anthony J Nastasi, Mara A McAdams-DeMarco, Jennifer Schrack, Hao Ying, Israel Olorundare, Fatima Warsame, Alexandra Mountford, Christine E Haugen, Marlís González Fernández, Silas P Norman, Dorry L Segev
Prediction models for post-kidney transplant (KT) mortality have had limited success (C-statistics≤0.70). Adding objective measures of potentially modifiable factors may improve prediction and, consequently, KT survival through intervention. The short physical performance battery (SPPB) is an easily administered objective test of lower extremity function consisting of three parts (balance, walking speed, chair stands), each with scores of 0-4, for a composite score of 0-12, with higher scores indicating better function...
July 15, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28710601/the-effects-of-collective-and-personal-transitions-on-the-organization-and-contents-of-autobiographical-memory-in-older-chinese-adults
#19
Xuan Gu, Chi-Shing Tse, Norman R Brown
Life transitions like war, marriage, and immigration presumably organize autobiographical memory. Yet little is known about how the magnitude of a given transition affects this mnemonic impact. To examine this issue, we collected (a) word-cued events, (b) event-dating protocols, (c) personally important events, and (d) transitional impact scores of the Cultural Revolution (1966-1976) and important events from Chinese adults who had been adolescents during the revolution. There were three main findings. First, rusticated participants, who moved from cities to rural areas during the Cultural Revolution, dated autobiographical memories in relation to this collective transition more frequently than nonrusticated participants, with the former group reporting a greater material (but not psychological) change in their lives due to this collective transition than the latter group...
July 14, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28710506/obese-versus-normal-weight-late-adolescent-females-have-inferior-trabecular-bone-microarchitecture-a-pilot-case-control-study
#20
Joseph M Kindler, Norman K Pollock, Hannah L Ross, Christopher M Modlesky, Harshvardhan Singh, Emma M Laing, Richard D Lewis
Though still a topic of debate, the position that skeletal health is compromised with obesity has received support in the pediatric and adult literature. The limited data relating specifically to trabecular bone microarchitecture, however, have been relatively inconsistent. The aim of this pilot cross-sectional case-control study was to compare trabecular bone microarchitecture between obese (OB) and normal-weight (NW) late-adolescent females. A secondary aim was to compare diaphyseal cortical bone outcomes between these two groups...
July 14, 2017: Calcified Tissue International
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