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https://www.readbyqxmd.com/read/29051134/a-telerehabilitation-approach-to-enhance-quality-of-life-through-exercise-among-adults-with-paraplegia-study-protocol
#1
Shane Norman Sweet, Meredith Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Brigitte Fillion
BACKGROUND: Despite compelling evidence linking physical activity and quality of life among adults with spinal cord injury (SCI), exercise participation rates are extremely low in this population. Unfortunately, a lack of behavioral exercise interventions, in particular theory-based randomized controlled trials (RCT), exists within the SCI literature. A pilot RCT is needed to first examine the feasibility to conduct such interventions and determine the appropriate effect size to inform future full-scale interventions...
October 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29050725/evaluation-of-mean-transit-time-of-aerosols-from-the-area-of-origin-to-the-arctic-with-210-pb-210-po-daily-monitoring-data
#2
Weihua Zhang, Baki Sadi, Christopher Rinaldo, Jing Chen, Norman Spencer, Kurt Ungar
In this study, the activity concentrations of (210)Pb and (210)Po on the 22 daily air filter samples, collected at CTBT Yellowknife station from September 2015 to April 2016, were analysed. To estimate the time scale of atmospheric long-range transport aerosol bearing (210)Pb in the Arctic during winter, the mean transit time of aerosol bearing (210)Pb from its origin was determined based on the activity ratios of (210)Po/(210)Pb and the parent-progeny decay/ingrowth equation. The activity ratios of (210)Po/(210)Pb varied between 0...
October 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29050686/gender-differences-in-cardiac-resynchronization-therapy-device-choice-and-outcome-in-patients-%C3%A2-75-years-of-age-with-heart-failure
#3
Yanting Wang, Michael S Sharbaugh, Mohammad Bilal Munir, Evan C Adelstein, Norman C Wang, Andrew D Althouse, Samir Saba
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure and can be delivered through a CRT pacemaker (CRT-P) or a CRT defibrillator (CRT-D). CRT-P devices are smaller and less expensive, have better battery longevity, and have been subject to fewer recalls and advisories but cannot deliver high-energy shocks to terminate potentially lethal ventricular arrhythmias. As published guidelines do not distinguish between CRT-P and CRT-D indications, we examined the practice of prescribing these devices in older women and men with heart failure...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29049819/treatment-of-a-degenerated-sutureless-sorin-perceval%C3%A2-valve-using-an-edwards-sapien-3
#4
Norman Mangner, David Holzhey, Martin Misfeld, Axel Linke
Valve-in-valve implantation is an alternative to reoperation for patients with degenerated bioprostheses. This case report presents a 75-year-old woman presenting with worsening dyspnoea according New York Heart Association (NYHA) Class III after she had received a Sorin Perceval® S sutureless valve due to severe aortic valve stenosis 5 years ago. Echocardiography revealed a degenerated Perceval valve with severe valvular aortic regurgitation and stenosis. After exclusion of acute infective endocarditis, an Edwards SAPIEN 3 was implanted leading to an immediate haemodynamic improvement...
October 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049267/variation-among-pediatric-orthopaedic-surgeons-when-treating-medial-epicondyle-fractures
#5
Meghan Hughes, Karan Dua, Nathan N O'Hara, Brian K Brighton, Theodore J Ganley, William L Hennrikus, Martin J Herman, Joshua E Hyman, J Todd Lawrence, Charles T Mehlman, Kenneth J Noonan, Norman Y Otsuka, Richard M Schwend, M Wade Shrader, Brian G Smith, Paul D Sponseller, Joshua M Abzug
BACKGROUND: Medial epicondyle fractures are a common pediatric and adolescent injury accounting for 11% to 20% of elbow fractures in this population. This purpose of this study was to determine the variability among pediatric orthopaedic surgeons when treating pediatric medial epicondyle fractures. METHODS: A discrete choice experiment was conducted to determine which patient and injury attributes influence the management of medial epicondyle fractures by pediatric orthopaedic surgeons...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29045575/shared-and-disorder-specific-neurocomputational-mechanisms-of-decision-making-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#6
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia
Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) often share phenotypes of repetitive behaviors, possibly underpinned by abnormal decision-making. To compare neural correlates underlying decision-making between these disorders, brain activation of boys with ASD (N = 24), OCD (N = 20) and typically developing controls (N = 20) during gambling was compared, and computational modeling compared performance. Patients were unimpaired on number of risky decisions, but modeling showed that both patient groups had lower choice consistency and relied less on reinforcement learning compared to controls...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29044759/liver-transplant-length-of-stay-los-index-a-novel-predictive-score-for-hospital-length-of-stay-following-liver-transplantation
#7
Abbas Rana, Ellen D Witte, Karim J Halazun, Gagan K Sood, Ayse L Mindikoglu, Norman Sussman, John M Vierling, Michael L Kueht, N Thao N Galvan, Ronald T Cotton, Christine A O'Mahony, John A Goss
An index to predict hospital length of stay after liver transplantation could address unmet clinical needs. Length of stay is an important surrogate for hospital costs and efforts to limit stays can preserve our healthcare resources. Here, we devised a scoring system that predicts hospital length of stay following liver transplantation. We used univariate and multivariate analyses on 73,635 adult liver transplant recipient data and identified independent recipient and donor risk factors for prolonged hospital stay (> 30 days)...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29043023/sapling-growth-rates-reveal-conspecific-negative-density-dependence-in-a-temperate-forest
#8
Benjamin S Ramage, Daniel J Johnson, Erika Gonzalez-Akre, William J McShea, Kristina J Anderson-Teixeira, Norman A Bourg, Keith Clay
Local tree species diversity is maintained in part by conspecific negative density dependence (CNDD). This pervasive mechanism occurs in a variety of forms and ecosystems, but research to date has been heavily skewed toward tree seedling survival in tropical forests. To evaluate CNDD more broadly, we investigated how sapling growth rates were affected by conspecific adult neighbors in a fully mapped 25.6 ha temperate deciduous forest. We examined growth rates as a function of the local adult tree neighborhood (via spatial autoregressive modeling) and compared the spatial positioning of faster-growing and slower-growing saplings with respect to adult conspecific and heterospecific trees (via bivariate point pattern analysis)...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042246/probabilistic-broken-stick-model-a-regression-algorithm-for-irregularly-sampled-data-with-application-to-egfr
#9
Norman Poh, Santosh Tirunagari, Nicholas Cole, Simon Lusignan
In order for clinicians to manage disease progression and make effective decisions about drug dosage, treatment regimens or scheduling follow up appointments, it is necessary to be able to identify both short and long-term trends in repeated biomedical measurements. However, this is complicated by the fact that these measurements are irregularly sampled and influenced by both genuine physiological changes and external factors. In their current forms, existing regression algorithms often do not fulfil all of a clinician's requirements for identifying short-term (acute) events while still being able to identify long-term, chronic, trends in disease progression...
October 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29040712/signal-uncertainty-and-conflict-in-phylogenomic-data-for-a-diverse-lineage-of-microbial-eukaryotes-diatoms-bacillariophyta
#10
Matthew B Parks, Norman J Wickett, Andrew J Alverson
Diatoms (Bacillariophyta) are a species-rich group of eukaryotic microbes diverse in morphology, ecology, and metabolism. Previous reconstructions of the diatom phylogeny based on one or a few genes have resulted in inconsistent resolution or low support for critical nodes. We applied phylogenetic paralog pruning techniques to a dataset of 94 diatom genomes and transcriptomes to infer perennially difficult species relationships, using concatenation and summary-coalescent methods to reconstruct species trees from datasets spanning a wide range of thresholds for taxon and column occupancy in gene alignments...
October 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29040462/both-cardiomyocyte-and-endothelial-cell-nox4-mediate-protection-against-hemodynamic-overload-induced-remodeling
#11
Min Zhang, Heloise Mongue-Din, Daniel Martin, Norman Catibog, Ioannis Smyrnias, Xiaohong Zhang, Bin Yu, Minshu Wang, Ralf P Brandes, Katrin Schröder, Ajay M Shah
Aims: NADPH oxidase-4 (Nox4) is an important reactive oxygen species (ROS) source that is upregulated in the hemodynamically overloaded heart. Our previous studies using global Nox4 knockout (Nox4KO) mice demonstrated a protective role of Nox4 during chronic abdominal aortic banding, involving a paracrine enhancement of myocardial capillary density. However, other authors who studied cardiac-specific Nox4KO mice reported detrimental effects of Nox4 in response to transverse aortic constriction (TAC)...
October 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29040221/thermoeffector-responses-at-a-fixed-rate-of-heat-production-in-heart-failure-patients
#12
Bryce N Balmain, Ollie Jay, Norman R Morris, Kenji Shiino, Glenn M Stewart, Rohan Jayasinghe, Jonathan Chan, Surendran Sabapathy
PURPOSE: Heart failure (HF) patients appear to exhibit altered thermoregulatory responses during exercise in the heat. However, the extent to which these responses are altered due to physiological impairments independently of biophysical factors associated with differences in metabolic heat production (Hprod), evaporative heat balance requirements (Ereq) and/or body size, is presently unclear. Therefore, we examined thermoregulatory responses in 10 HF and 10 age-matched controls (CON) similar in body size during exercise at a fixed rate of Hprod, and therefore Ereq in a 30°C environment...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29040076/total-coliform-and-escherichia-coli-contamination-in-rural-well-water-analysis-for-passive-surveillance
#13
Jesse Invik, Herman W Barkema, Alessandro Massolo, Norman F Neumann, Sylvia Checkley
With increasing stress on our water resources and recent waterborne disease outbreaks, understanding the epidemiology of waterborne pathogens is crucial to build surveillance systems. The purpose of this study was to explore techniques for describing microbial water quality in rural drinking water wells, based on spatiotemporal analysis, time series analysis and relative risk mapping. Tests results for Escherichia coli and coliforms from private and small public well water samples, collected between 2004 and 2012 in Alberta, Canada, were used for the analysis...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29038446/external-quality-assurance-for-laboratory-identification-and-capsular-typing-of-streptococcus-pneumoniae
#14
Hans-Christian Slotved, Carmen L Sheppard, Tine Dalby, Arie van der Ende, Norman K Fry, Eva Morfeldt, Outi Nyholm, Assaf Rokney, Merav Ron, Lotta Siira, Kevin J Scott, Andrew Smith, Louise Thom, Maija Toropainen, Didrik F Vestrheim
An external quality assessment (EQA) scheme for pneumococcal serotype identification has been performed over a period of 11 years, by a network of European pneumococcal reference laboratories. We report the results from the EQA, and present an assessment of the acceptability and utility of the EQA scheme. Reports from 22 EQA panels distributed in 2005-2016 were analysed. Each EQA panel consisted of seven isolates. A questionnaire including seven questions related to the acceptability and utility of the EQA scheme was distributed to all participating laboratories...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038415/two-perspectives-of-the-appropriate-use-criteria-in-cardiology-practice-advantageous-and-useful-or-limiting-and-harmful
#15
Sandeep K Krishnan, Amit Bahia, Ralph G Brindis, Norman E Lepor, Dipti Itchhaporia, Pranav M Patel
The appropriate use criteria (AUC) has become an integral part of the cardiologist's daily practice and have evolved greatly since their inception over a decade ago. However, as health care costs continue to rise, the AUC has come to play an even more pivotal role in the way medicine-specifically cardiology-is practiced today. This editorial describes two opposing viewpoints commonly held by practicing clinicians of the AUC. Written from the perspective of two fellows-in-training looking ahead at the challenges and opportunities of clinical practice (under the auspices of several experienced clinicians and leaders of the American College of Cardiology), this article provides a fresh perspective on the impact AUC has on our patients, clinicians, and the health care system...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29037662/effects-of-pharmacological-manipulation-of-the-kappa-opioid-receptors-on-the-aversive-effects-of-nicotine
#16
Melissa Ward, Haval Norman, Manoranjan S D'Souza
Nicotine, an addictive component of tobacco smoke, produces both rewarding and aversive effects. Increasing the aversive effects of nicotine may help in promoting smoking cessation. However, neural targets mediating the aversive effects of nicotine have not been fully identified. In this study, we evaluated the role of kappa opioid receptors (KORs) in the aversive effects of nicotine (0.4 mg/kg, base; s.c.) using the nicotine-induced conditioned taste aversion (CTA) model in Wistar rats. The KORs were activated using the selective KOR agonist (±)U-50,488H (0, 0...
October 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29036056/coherent-field-propagation-between-tilted-planes
#17
Johannes Stock, Norman Girma Worku, Herbert Gross
Propagating electromagnetic light fields between nonparallel planes is of special importance, e.g., within the design of novel computer-generated holograms or the simulation of optical systems. In contrast to the extensively discussed evaluation between parallel planes, the diffraction-based propagation of light onto a tilted plane is more burdensome, since discrete fast Fourier transforms cannot be applied directly. In this work, we propose a quasi-fast algorithm (O(N(3) log N)) that deals with this problem...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035703/a-randomized-clinical-trial-examining-the-effects-of-an-anxiety-sensitivity-intervention-on-insomnia-symptoms-replication-and-extension
#18
Nicole A Short, Joseph W Boffa, Savannah King, Brian J Albanese, Nicholas P Allan, Norman B Schmidt
Insomnia disorder is impairing and prevalent, particularly among individuals with comorbid anxiety disorders. Despite the availability of effective computerized treatments for insomnia, there are few that target both insomnia as well as co-occurring anxiety symptoms. The current study tests the efficacy of a computerized treatment for anxiety sensitivity cognitive concerns, a transdiagnostic risk factor for anxiety, mood, and insomnia symptoms, against a repeated contact control, on reducing insomnia symptoms...
October 5, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29034678/additive-models-reveal-sources-of-metals-and-organic-pollutants-in-norwegian-marine-sediments
#19
Gert Everaert, Anders Ruus, Dag Øystein Hjermann, Katrine Borgå, Norman Green, Stepan Boitsov, Henning Jensen, Amanda E Poste
We characterized spatial patterns of surface sediment concentrations of seven polychlorinated biphenyls (PCBs), seven polycyclic aromatic hydrocarbons (PAHs), three chlorinated pesticides and five metals in Norwegian waters and Skagerrak. In total, we analysed 5,036 concentrations of 22 chemical substances that were measured between 1986 and 2014 at 333 sampling sites by means of generalized additive models (GAMs). We found that GAMs with organic carbon content of the sediment and latitude and longitude as covariates explained ca...
October 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29033457/emerging-and-evolving-concepts-in-gene-essentiality
#20
REVIEW
Giulia Rancati, Jason Moffat, Athanasios Typas, Norman Pavelka
Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases...
October 16, 2017: Nature Reviews. Genetics
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