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Pima indian diabetes

Ramalingaswamy Cheruku, Damodar Reddy Edla, Venkatanareshbabu Kuppili
Diabetes is a major health challenge around the world. Existing rule-based classification systems have been widely used for diabetes diagnosis, even though they must overcome the challenge of producing a comprehensive optimal ruleset while balancing accuracy, sensitivity and specificity values. To resolve this drawback, in this paper, a Spider Monkey Optimization-based rule miner (SM-RuleMiner) has been proposed for diabetes classification. A novel fitness function has also been incorporated into SM-RuleMiner to generate a comprehensive optimal ruleset while balancing accuracy, sensitivity and specificity...
December 19, 2016: Computers in Biology and Medicine
K M Venkat Narayan
Diabetes is among the biggest of the 21st-century global health challenges. In the U.S. and other high-income countries, thanks to investments in science, dedication to implementing these findings, and measurement of quality of care, there have been improvements in diabetes management and declines in rate of diabetes complications and mortality. This good news, however, is overshadowed by the ever-increasing absolute numbers of people with diabetes and its complications and the unprecedented growth of diabetes in low- and middle-income countries of the world...
May 2016: Diabetes Care
Robert C Williams, Robert C Elston, Pankaj Kumar, William C Knowler, Hanna E Abboud, Sharon Adler, Donald W Bowden, Jasmin Divers, Barry I Freedman, Robert P Igo, Eli Ipp, Sudha K Iyengar, Paul L Kimmel, Michael J Klag, Orly Kohn, Carl D Langefeld, David J Leehey, Robert G Nelson, Susanne B Nicholas, Madeleine V Pahl, Rulan S Parekh, Jerome I Rotter, Jeffrey R Schelling, John R Sedor, Vallabh O Shah, Michael W Smith, Kent D Taylor, Farook Thameem, Denyse Thornley-Brown, Cheryl A Winkler, Xiuqing Guo, Phillip Zager, Robert L Hanson
BACKGROUND: The presence of population structure in a sample may confound the search for important genetic loci associated with disease. Our four samples in the Family Investigation of Nephropathy and Diabetes (FIND), European Americans, Mexican Americans, African Americans, and American Indians are part of a genome- wide association study in which population structure might be particularly important. We therefore decided to study in detail one component of this, individual genetic ancestry (IGA)...
May 4, 2016: BMC Genomics
Anup K Nair, Leslie J Baier
Genetic studies in large outbred populations have documented a complex, highly polygenic basis for type 2 diabetes (T2D). Most of the variants currently known to be associated with T2D risk have been identified in large studies that included tens of thousands of individuals who are representative of a single major ethnic group such as European, Asian, or African. However, most of these variants have only modest effects on the risk for T2D; identification of definitive 'causal variant' or 'causative loci' is typically lacking...
October 2015: Review of Diabetic Studies: RDS
M G Hohenadel, L J Baier, P Piaggi, Y L Muller, R L Hanson, J Krakoff, M S Thearle
BACKGROUND: Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of such variants are likely to occur. Our ongoing studies to identify genetic determinants of obesity in American Indians have identified 67 single-nucleotide polymorphisms (SNPs) that reproducibly associate with maximum lifetime non-diabetic body mass index (BMI). This study aimed to identify when, during the lifetime, these variants have their greatest impact on BMI increase...
August 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Kevin M Wheelock, Mamta Jaiswal, Catherine L Martin, Gudeta D Fufaa, E Jennifer Weil, Kevin V Lemley, Berne Yee, Eva Feldman, Frank C Brosius, William C Knowler, Robert G Nelson, Rodica Pop-Busui
AIMS: Cardiovascular autonomic neuropathy (CAN) predicts clinical diabetic nephropathy (DN). We investigated the relationship between DN structural lesions and CAN. METHODS: Sixty three Pima Indians with type 2 diabetes underwent kidney biopsies following a 6-year clinical trial testing the renoprotective efficacy of losartan vs. placebo. CAN was assessed a median 9.2years later. CAN variables included expiration/inspiration ratio (E/I), standard deviation of the normal R-R interval (sdNN), and low and high frequency signal power and their ratio (LF, HF, LF/HF); lower values reflect more severe neuropathy...
July 2016: Journal of Diabetes and its Complications
Kevin M Wheelock, Madhumita Sinha, William C Knowler, Robert G Nelson, Gudeta D Fufaa, Robert L Hanson
Four childhood metabolic risk factors were assessed as predictors of future type 2 diabetes; obesity and impaired glucose tolerance were strong predictors, hypertension and dyslipidemia were not.
April 2016: Journal of Clinical Endocrinology and Metabolism
Douglas C Chang, Paolo Piaggi, Robert L Hanson, William C Knowler, John Bucci, Guene Thio, Maximilian G Hohenadel, Clifton Bogardus, Jonathan Krakoff
New biomarkers for type 2 diabetes mellitus (T2DM) may aid diagnosis, drug development or clinical treatment. Evidence is increasing for the adaptive immune system's role in T2DM and suggests the presence of unidentified autoantibodies. While high-density protein microarrays have emerged as a useful technology to identify possible novel autoantigens in autoimmune diseases, its application in T2DM has lagged. In Pima Indians, the HLA haplotype (HLA-DRB1*02) is protective against T2DM and, when studied when they have normal glucose tolerance, subjects with this HLA haplotype have higher insulin secretion compared to those without the protective haplotype...
2015: PloS One
Ewan R Pearson
No abstract text is available yet for this article.
December 2015: Diabetes
Joseph A Frankl, Marie S Thearle, Cindy Desmarais, Clifton Bogardus, Jonathan Krakoff
BACKGROUND: Recent work in Pima Indians, a population with high rates of obesity and type 2 diabetes mellitus (T2DM), demonstrated that human leukocyte antigen haplotype DRB1*02 carriers have an increased acute insulin response and decreased risk for the development of T2DM, implicating loss of self-tolerance in the pathogenesis of T2DM. Advances in genomic sequencing have made T-cell receptor repertoire analysis a practical mode of investigation. METHODS: High-throughput sequencing of T-cell receptor complementarity-determining region 3 was carried out in male Pima Indians with normal glucose regulation (n = 11; age = 31 ± 8 years; %fat = 30...
March 2016: Diabetes/metabolism Research and Reviews
Yunhua L Muller, Robert L Hanson, Gregory Wiessner, Lori Nieboer, Sayuko Kobes, Paolo Piaggi, Mahdi Abdussamad, Chidinma Okani, William C Knowler, Clifton Bogardus, Leslie J Baier
OBJECTIVE: A prior genome-wide association study (GWAS) in Pima Indians identified variation within FOXO1A that modestly associated with early-onset (onset age < 25 years) type 2 diabetes (T2D). FOXO1A encodes the forkhead transcription factor involved in pancreatic β-cell growth and hypothalamic energy balance; therefore, FOXO1A was analyzed as a candidate gene for T2D and obesity in a population-based sample of 7,710 American Indians. METHODS: Tag SNPs in/near FOXO1A (minor allele frequency ≥ 0...
October 2015: Obesity
Julian Esparza-Romero, Mauro E Valencia, Rene Urquidez-Romero, Lisa S Chaudhari, Robert L Hanson, William C Knowler, Eric Ravussin, Peter H Bennett, Leslie O Schulz
OBJECTIVE: The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS: Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995...
November 2015: Diabetes Care
Leslie J Baier, Yunhua Li Muller, Maria Sara Remedi, Michael Traurig, Paolo Piaggi, Gregory Wiessner, Ke Huang, Alyssa Stacy, Sayuko Kobes, Jonathan Krakoff, Peter H Bennett, Robert G Nelson, William C Knowler, Robert L Hanson, Colin G Nichols, Clifton Bogardus
Missense variants in KCNJ11 and ABCC8, which encode the KIR6.2 and SUR1 subunits of the β-cell KATP channel, have previously been implicated in type 2 diabetes, neonatal diabetes, and hyperinsulinemic hypoglycemia of infancy (HHI). To determine whether variation in these genes affects risk for type 2 diabetes or increased birth weight as a consequence of fetal hyperinsulinemia in Pima Indians, missense and common noncoding variants were analyzed in individuals living in the Gila River Indian Community. A R1420H variant in SUR1 (ABCC8) was identified in 3...
December 2015: Diabetes
Filipe Valvassori do Nascimento, Vanessa Piccoli, Mayara Abichequer Beer, Anize Delfino von Frankenberg, Daisy Crispim, Fernando Gerchman
The HSD11B1 gene is highly expressed in abdominal adipose tissue, and the enzyme it encodes catalyzes the interconversion of inactive cortisone to hormonally active cortisol. Genetic abnormalities of HSD11B1 have been associated with the development of abnormal glucose metabolism and body fat distribution. To systematically review studies evaluating the association of HSD11B1 gene expression in abdominal adipose tissue and HSD11B1 polymorphisms with obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM), we conducted a search in MEDLINE, SCOPUS, and Cochrane Library databases in April 2015...
2015: Diabetology & Metabolic Syndrome
Joseph M Yracheta, Miguel A Lanaspa, MyPhuong T Le, Manal F Abdelmalak, Javier Alfonso, Laura G Sánchez-Lozada, Richard J Johnson
Since the early 20th century, a marked increase in obesity, diabetes, and chronic kidney disease has occurred in the American Indian population, especially the Pima Indians of the Southwest. Here, we review the current epidemic and attempt to identify remediable causes. A search was performed using PubMed and the search terms American Indian and obesity, American Indian and diabetes, American Indian and chronic kidney disease, and American Indian and sugar or fructose, Native American, Alaska Native, First Nations, Aboriginal, Amerind, and Amerindian for American Indian for articles linking American Indians with diabetes, obesity, chronic kidney disease, and sugar; additional references were identified in these publications traced to 1900 and articles were reviewed if they were directly discussing these topics...
June 2015: Mayo Clinic Proceedings
Leslie O Schulz, Lisa S Chaudhari
The purpose of this review is first, to broadly summarize the long-term commitment that began in 1965 to studying type 2 diabetes and obesity through the cooperation of the Pima Indians of Arizona, and second, to discuss the investigations with the Pima Indians of Mexico that started in 1991. The later studies emphasize gene-environment interactions in the pathogenesis of these metabolic disorders. Through the participation of both groups of Pimas, the researchers made key findings with regard to the epidemiology, physiology, clinical assessment and genetics of type 2 diabetes and obesity...
March 2015: Current Obesity Reports
Mohammad Reza Daliri
In this article, we propose a feature selection strategy using a binary particle swarm optimization algorithm for the diagnosis of different medical diseases. The support vector machines were used for the fitness function of the binary particle swarm optimization. We evaluated our proposed method on four databases from the machine learning repository, including the single proton emission computed tomography heart database, the Wisconsin breast cancer data set, the Pima Indians diabetes database, and the Dermatology data set...
October 2012: Biomedizinische Technik. Biomedical Engineering
Meredith C Foster, Lesley A Inker, Chi-Yuan Hsu, John H Eckfeldt, Andrew S Levey, Meda E Pavkov, Bryan D Myers, Peter H Bennett, Paul L Kimmel, Ramachandran S Vasan, Josef Coresh, Robert G Nelson
BACKGROUND: A growing number of serum filtration markers are associated with mortality and end-stage renal disease (ESRD) in adults. Whether β-trace protein (BTP) and β2-microglobulin (B2M) are associated with these outcomes in adults with type 2 diabetes is not known. STUDY DESIGN: Longitudinal cohort study. SETTING & PARTICIPANTS: 250 Pima Indians with type 2 diabetes (69% women; mean age, 42 years; mean diabetes duration, 11 years). PREDICTORS: Serum BTP, B2M, and glomerular filtration rate measured by iothalamate clearance (mGFR) or estimated using creatinine (eGFRcr) or cystatin C level (eGFRcys)...
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yunhua L Muller, Paolo Piaggi, Robert L Hanson, Sayuko Kobes, Shujera Bhutta, Maryam Abdussamad, Tennille Leak-Johnson, Matthias Kretzler, Ke Huang, E Jennifer Weil, Robert G Nelson, William C Knowler, Clifton Bogardus, Leslie J Baier
A prior genome-wide association study (GWAS) in Pima Indians identified a variant within PFKFB2 (rs17258746) associated with body mass index (BMI). PFKFB2 encodes 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase isoform 2, which plays a role in glucose metabolism. To follow-up on the GWAS, tag SNPs across PFKFB2 were genotyped in American Indians (AI) who had longitudinal data on BMI (n = 6839), type 2 diabetes (T2D; n = 7710), diabetic nephropathy (DN; n = 2452), % body fat (n = 555) and insulin secretion (n = 298)...
May 15, 2015: Human Molecular Genetics
R Cruz Begay, Lisa S Chaudhari, Julian Esparza-Romero, Rene Urquidez Romero, Leslie O Schulz
Gardens are an important part of the environment as they play multiple roles and are central to the lifestyle and economy of many communities. The investigators use qualitative methods to explore patterns and perceptions about changes in gardening and cultivation in the community of Maycoba, Mexico. Maycoba is home to a large community of Pima Indians, an Indigenous population genetically prone to diabetes. Pima Indians living in the United States have been shown to have an extremely high prevalence of diabetes, but the genetically comparable Pimas in Maycoba, Mexico, were found to have little diabetes in the early 1990s...
March 2011: International Journal of Health, Wellness & Society
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