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Pima indian diabetes

Wen-Chi Hsueh, Peter H Bennett, Julian Esparza-Romero, Rene Urquidez-Romero, Mauro E Valencia, Eric Ravussin, Robert C Williams, William C Knowler, Leslie J Baier, Leslie O Schulz, Robert L Hanson
Prevalence of diabetes and obesity in Mexican Pima Indians is low, while prevalence in US Pima Indians is high. Although lifestyle likely accounts for much of the difference, the role of genetic factors is not well explored. To examine this, we genotyped 359 single nucleotide polymorphisms, including established type 2 diabetes and obesity variants from genome-wide association studies (GWAS) and 96 random markers, in 342 Mexican Pimas. A multimarker risk score of obesity variants was associated with body mass index (BMI; β = 0...
May 17, 2018: Annals of Human Genetics
Chengxiang Qiu, Robert L Hanson, Gudeta Fufaa, Sayuko Kobes, Caroline Gluck, Jing Huang, Yong Chen, Dominic Raj, Robert G Nelson, William C Knowler, Katalin Susztak
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes, but the molecular mechanisms by which nephropathy develops are largely unknown. Here we tested cytosine methylation levels at 397,063 genomic CpG sites for association with decline in the estimated glomerular filtration rate (eGFR) over a six year period in 181 diabetic Pima Indians. Methylation levels at 77 sites showed significant association with eGFR decline after correction for multiple comparisons. A model including methylation level at two probes (cg25799291 and cg22253401) improved prediction of eGFR decline in addition to baseline eGFR and the albumin to creatinine ratio with the percent of variance explained significantly improving from 23...
April 27, 2018: Kidney International
Fatemeh Mansourypoor, Shahrokh Asadi
The early diagnosis of disease is critical to preventing the occurrence of severe complications. Diabetes is a serious health problem. A variety of methods have been developed for diagnosing diabetes. The majority of these methods have been developed in a black-box manner, which cannot be used to explain the inference and diagnosis procedure. Therefore, it is essential to develop methods with high accuracy and interpretability. In this study, a Reinforcement Learning-based Evolutionary Fuzzy Rule-Based System (RLEFRBS) is developed for diabetes diagnosis...
October 31, 2017: Computers in Biology and Medicine
Viji Nair, Claudiu V Komorowsky, E Jennifer Weil, Berne Yee, Jeffrey Hodgin, Jennifer L Harder, Bradley Godfrey, Wenjun Ju, Carine M Boustany-Kari, Margrit Schwarz, Kevin V Lemley, Peter J Nelson, Robert G Nelson, Matthias Kretzler
Diabetic kidney disease is the leading cause of kidney failure. However, studies of molecular mechanisms of early kidney damage are lacking. Here we examined for possible linkage between transcriptional regulation and quantitative structural damage in early diabetic kidney disease in Pima Indians with type 2 diabetes. Tissue obtained from protocol kidney biopsies underwent genome-wide compartment-specific gene expression profiling and quantitative morphometric analysis. The ultrastructural lesion most strongly associated with transcriptional regulation was cortical interstitial fractional volume (VvInt), an index of tubule-interstitial damage...
February 2018: Kidney International
Md Maniruzzaman, Nishith Kumar, Md Menhazul Abedin, Md Shaykhul Islam, Harman S Suri, Ayman S El-Baz, Jasjit S Suri
BACKGROUND AND OBJECTIVE: Diabetes is a silent killer. The main cause of this disease is the presence of excessive amounts of metabolites such as glucose. There were about 387 million diabetic people all over the world in 2014. The financial burden of this disease has been calculated to be about $13,700 per year. According to the World Health Organization (WHO), these figures will more than double by the year 2030. This cost will be reduced dramatically if someone can predict diabetes statistically on the basis of some covariates...
December 2017: Computer Methods and Programs in Biomedicine
Kevin M Wheelock, Pierre-Jean Saulnier, Stephanie K Tanamas, Pavithra Vijayakumar, E Jennifer Weil, Helen C Looker, Robert L Hanson, Kevin V Lemley, Berne Yee, William C Knowler, Samy Hadjadj, Bezhad Najafian, Michael Mauer, Robert G Nelson
Background: Inflammation linked to diabetic kidney disease (DKD) may affect white blood cell (WBC) counts and differentials. We examined the cross-sectional associations of total WBC count and WBC fractions with structural lesions of DKD in 108 Pima Indians with Type 2 diabetes who underwent research kidney biopsies. We also examined the longitudinal association of these WBC variables with renal function loss (RFL) in 941 Europeans with Type 2 diabetes from the SURDIAGENE study. Methods: Associations of WBC variables with morphometric parameters were assessed by linear regression...
July 18, 2017: Nephrology, Dialysis, Transplantation
Paolo Piaggi, Ivica Masindova, Yunhua L Muller, Josep Mercader, Gregory B Wiessner, Peng Chen, Sayuko Kobes, Wen-Chi Hsueh, Milliejoan Mongalo, William C Knowler, Jonathan Krakoff, Robert L Hanson, Clifton Bogardus, Leslie J Baier
Pima Indians living in Arizona have a high prevalence of obesity, and we have previously shown that a relatively lower energy expenditure (EE) predicts weight and fat mass gain in this population. EE is a familial trait (heritability = 0.52); therefore, in the current study, we aimed to identify genetic variants that affect EE and thereby influence BMI and body fatness in Pima Indians. Genotypic data from 491,265 variants were analyzed for association with resting metabolic rate (RMR) and 24-h EE assessed in a whole-room calorimeter in 507 and 419 Pima Indians, respectively...
August 2017: Diabetes
Pavithra Vijayakumar, Annika Hoyer, Robert G Nelson, Ralph Brinks, Meda E Pavkov
The objective was to estimate chronic kidney disease (CKD) incidence rates from prevalence and mortality data, and compare the estimates with observed (true) incidence rates in a well-characterized population with diabetes. Pima Indians aged 20 years and older with type 2 diabetes were followed from 1982 through 2007. CKD was defined by estimated GFR (eGFR) <60 ml/min/1.72 m2 or albumin-to-creatinine ratio (ACR) ≥30 mg/g. True CKD incidence and mortality rates were computed for the whole study period, and prevalence for the intervals 1982-1994 and 1995-2007...
2017: PloS One
Peng Chen, Paolo Piaggi, Michael Traurig, Clifton Bogardus, William C Knowler, Leslie J Baier, Robert L Hanson
AIMS/HYPOTHESIS: Individuals exposed to maternal diabetes in utero are more likely to develop metabolic and cardiovascular diseases later in life. This may be partially attributable to epigenetic regulation of gene expression. We performed an epigenome-wide association study to examine whether differential DNA methylation, a major source of epigenetic regulation, can be observed in offspring of mothers with type 2 diabetes during the pregnancy (OMD) compared with offspring of mothers with no diabetes during the pregnancy (OMND)...
April 2017: Diabetologia
Kaitlyn Bloom, Al-Walid Mohsen, Anuradha Karunanidhi, Dina El Demellawy, Miguel Reyes-Múgica, Yudong Wang, Lina Ghaloul-Gonzalez, Chikara Otsubo, Kimi Tobita, Radhika Muzumdar, Zhenwei Gong, Emir Tas, Shrabani Basu, Jie Chen, Michael Bennett, Charles Hoppel, Jerry Vockley
The Native American Pima population has the highest incidence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) of any reported population, but the pathophysiologic mechanism is unknown. Genetic studies in Pima Indians have linked acyl-CoA dehydrogenase 10 (ACAD10) gene polymorphisms, among others, to this predisposition. The gene codes for a protein with a C-terminus region that is structurally similar to members of a family of flavoenzymes-the acyl-CoA dehydrogenases (ACADs)-that catalyze α,β-dehydrogenation reactions, including the first step in mitochondrial FAO (FAO), and intermediary reactions in amino acids catabolism...
January 2018: Journal of Inherited Metabolic Disease
Ramalingaswamy Cheruku, Damodar Reddy Edla, Venkatanareshbabu Kuppili
Diabetes is a major health challenge around the world. Existing rule-based classification systems have been widely used for diabetes diagnosis, even though they must overcome the challenge of producing a comprehensive optimal ruleset while balancing accuracy, sensitivity and specificity values. To resolve this drawback, in this paper, a Spider Monkey Optimization-based rule miner (SM-RuleMiner) has been proposed for diabetes classification. A novel fitness function has also been incorporated into SM-RuleMiner to generate a comprehensive optimal ruleset while balancing accuracy, sensitivity and specificity...
February 1, 2017: Computers in Biology and Medicine
K M Venkat Narayan
Diabetes is among the biggest of the 21st-century global health challenges. In the U.S. and other high-income countries, thanks to investments in science, dedication to implementing these findings, and measurement of quality of care, there have been improvements in diabetes management and declines in rate of diabetes complications and mortality. This good news, however, is overshadowed by the ever-increasing absolute numbers of people with diabetes and its complications and the unprecedented growth of diabetes in low- and middle-income countries of the world...
May 2016: Diabetes Care
Robert C Williams, Robert C Elston, Pankaj Kumar, William C Knowler, Hanna E Abboud, Sharon Adler, Donald W Bowden, Jasmin Divers, Barry I Freedman, Robert P Igo, Eli Ipp, Sudha K Iyengar, Paul L Kimmel, Michael J Klag, Orly Kohn, Carl D Langefeld, David J Leehey, Robert G Nelson, Susanne B Nicholas, Madeleine V Pahl, Rulan S Parekh, Jerome I Rotter, Jeffrey R Schelling, John R Sedor, Vallabh O Shah, Michael W Smith, Kent D Taylor, Farook Thameem, Denyse Thornley-Brown, Cheryl A Winkler, Xiuqing Guo, Phillip Zager, Robert L Hanson
BACKGROUND: The presence of population structure in a sample may confound the search for important genetic loci associated with disease. Our four samples in the Family Investigation of Nephropathy and Diabetes (FIND), European Americans, Mexican Americans, African Americans, and American Indians are part of a genome- wide association study in which population structure might be particularly important. We therefore decided to study in detail one component of this, individual genetic ancestry (IGA)...
May 4, 2016: BMC Genomics
Anup K Nair, Leslie J Baier
Genetic studies in large outbred populations have documented a complex, highly polygenic basis for type 2 diabetes (T2D). Most of the variants currently known to be associated with T2D risk have been identified in large studies that included tens of thousands of individuals who are representative of a single major ethnic group such as European, Asian, or African. However, most of these variants have only modest effects on the risk for T2D; identification of definitive 'causal variant' or 'causative loci' is typically lacking...
October 2015: Review of Diabetic Studies: RDS
M G Hohenadel, L J Baier, P Piaggi, Y L Muller, R L Hanson, J Krakoff, M S Thearle
BACKGROUND: Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of such variants are likely to occur. Our ongoing studies to identify genetic determinants of obesity in American Indians have identified 67 single-nucleotide polymorphisms (SNPs) that reproducibly associate with maximum lifetime non-diabetic body mass index (BMI). This study aimed to identify when, during the lifetime, these variants have their greatest impact on BMI increase...
August 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Kevin M Wheelock, Mamta Jaiswal, Catherine L Martin, Gudeta D Fufaa, E Jennifer Weil, Kevin V Lemley, Berne Yee, Eva Feldman, Frank C Brosius, William C Knowler, Robert G Nelson, Rodica Pop-Busui
AIMS: Cardiovascular autonomic neuropathy (CAN) predicts clinical diabetic nephropathy (DN). We investigated the relationship between DN structural lesions and CAN. METHODS: Sixty three Pima Indians with type 2 diabetes underwent kidney biopsies following a 6-year clinical trial testing the renoprotective efficacy of losartan vs. placebo. CAN was assessed a median 9.2years later. CAN variables included expiration/inspiration ratio (E/I), standard deviation of the normal R-R interval (sdNN), and low and high frequency signal power and their ratio (LF, HF, LF/HF); lower values reflect more severe neuropathy...
July 2016: Journal of Diabetes and its Complications
Kevin M Wheelock, Madhumita Sinha, William C Knowler, Robert G Nelson, Gudeta D Fufaa, Robert L Hanson
Four childhood metabolic risk factors were assessed as predictors of future type 2 diabetes; obesity and impaired glucose tolerance were strong predictors, hypertension and dyslipidemia were not.
April 2016: Journal of Clinical Endocrinology and Metabolism
Douglas C Chang, Paolo Piaggi, Robert L Hanson, William C Knowler, John Bucci, Guene Thio, Maximilian G Hohenadel, Clifton Bogardus, Jonathan Krakoff
New biomarkers for type 2 diabetes mellitus (T2DM) may aid diagnosis, drug development or clinical treatment. Evidence is increasing for the adaptive immune system's role in T2DM and suggests the presence of unidentified autoantibodies. While high-density protein microarrays have emerged as a useful technology to identify possible novel autoantigens in autoimmune diseases, its application in T2DM has lagged. In Pima Indians, the HLA haplotype (HLA-DRB1*02) is protective against T2DM and, when studied when they have normal glucose tolerance, subjects with this HLA haplotype have higher insulin secretion compared to those without the protective haplotype...
2015: PloS One
Ewan R Pearson
No abstract text is available yet for this article.
December 2015: Diabetes
Joseph A Frankl, Marie S Thearle, Cindy Desmarais, Clifton Bogardus, Jonathan Krakoff
BACKGROUND: Recent work in Pima Indians, a population with high rates of obesity and type 2 diabetes mellitus (T2DM), demonstrated that human leukocyte antigen haplotype DRB1*02 carriers have an increased acute insulin response and decreased risk for the development of T2DM, implicating loss of self-tolerance in the pathogenesis of T2DM. Advances in genomic sequencing have made T-cell receptor repertoire analysis a practical mode of investigation. METHODS: High-throughput sequencing of T-cell receptor complementarity-determining region 3 was carried out in male Pima Indians with normal glucose regulation (n = 11; age = 31 ± 8 years; %fat = 30...
March 2016: Diabetes/metabolism Research and Reviews
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