keyword
MENU ▼
Read by QxMD icon Read
search

Genetics diabetes

keyword
https://www.readbyqxmd.com/read/29682912/diabetic-macular-oedema-under-represented-in-the-genetic-analysis-of-diabetic-retinopathy
#1
REVIEW
Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease and is one of the leading causes of blindness in adults worldwide. It can be divided into distinct subclasses, one of which is diabetic macular oedema. Diabetic macular oedema can occur at any time in diabetic retinopathy and is the most common cause of vision loss in patients with type 2 diabetes. The purpose of this review is to summarize the large number of genetic association studies that have been performed in cohorts of patients with type 2 diabetes and published in English-language journals up to February 2017...
April 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29681852/genotypic-and-phenotypic-factors-influencing-drug-response-in-mexican-patients-with-type-2-diabetes-mellitus
#2
Hector E Sanchez-Ibarra, Luisa M Reyes-Cortes, Xian-Li Jiang, Claudia M Luna-Aguirre, Dionicio Aguirre-Trevino, Ivan A Morales-Alvarado, Rafael B Leon-Cachon, Fernando Lavalle-Gonzalez, Faruck Morcos, Hugo A Barrera-Saldaña
The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others. The marked inter-individual differences among T2DM patients' response to these drugs have become an issue on prescribing and dosing efficiently. In this study, fourteen polymorphisms selected from Genome-wide association studies (GWAS) were screened in 495 T2DM Mexican patients previously treated with OADs to find the relationship between the presence of these polymorphisms and response to the OADs...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681170/perceptions-of-family-among-low-income-patients-with-diabetes-in-a-text-based-mobile-health-intervention
#3
Elizabeth R E Burner, Michael D Menchine, Katrina Kubicek, Marisela Robles, Marjorie Kagawa Singer, Sanjay Arora
BACKGROUND: Diabetes disproportionately affects the US Latino population, due to socioeconomic pressures, genetics, reduced access to care and cultural practices. While efforts to improve self-care through interventions incorporating family are highly rated by Latinos, family can be both supportive and obstructive. To develop effective interventions, this role needs clarification. METHODS: We conducted group interviews in Spanish and English with 24 participants with diabetes from a mobile health diabetes self-care intervention...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29679742/adaptive-thermogenesis-by-dietary-n-3-polyunsaturated-fatty-acids-emerging-evidence-and-mechanisms
#4
REVIEW
Rong Fan, Karsten Koehler, Soonkyu Chung
Brown/beige fat plays a crucial role in maintaining energy homeostasis through non-shivering thermogenesis in response to cold temperature and excess nutrition (adaptive thermogenesis). Although numerous molecular and genetic regulators have been identified, relatively little information is available regarding thermogenic dietary molecules. Recently, a growing body of evidence suggests that high consumption of n-3 polyunsaturated fatty acids (PUFA) or activation of GPR120, a membrane receptor of n-3 PUFA, stimulate adaptive thermogenesis...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29679259/dna-methylation-a-potential-source-of-mitochondria-dna-base-mismatch-in-the-development-of-diabetic-retinopathy
#5
Manish Mishra, Renu A Kowluru
In the development of diabetic retinopathy, retinal mitochondria are dysfunctional, and mitochondrial DNA (mtDNA) is damaged with increased base mismatches and hypermethylated cytosines. DNA methylation is also a potential source of mutation, and in diabetes, the noncoding region, the displacement loop (D-loop), experiences more methylation and base mismatches than other regions of the mtDNA. Our aim was to investigate a possible crosstalk between mtDNA methylation and base mismatches in the development of diabetic retinopathy...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29679103/slc30a8-polymorphism-and-bmi-complement-hla-a-24-as-risk-factors-for-poor-graft-function-in-islet-allograft-recipients
#6
Else M Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J Van der Auwera, Zhidong Ling, Bart O Roep, Daniël G Pipeleers, Bart Keymeulen, Frans K Gorus
AIMS/HYPOTHESIS: HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients' zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome. METHODS: We retrospectively analysed data of a hospital-based patient cohort followed for 18 months post transplantation...
April 20, 2018: Diabetologia
https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#7
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29677089/re-the-recent-paper-genetic-determinants-of-impaired-awareness-of-hypoglycaemia-in-type-1-diabetes
#8
Ulrik Pedersen-Bjergaard, Birger Thorsteinsson
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29675560/patterns-of-differential-gene-expression-in-a-cellular-model-of-human-islet-development-and-relationship-to-type-2-diabetes-predisposition
#9
Marta Perez-Alcantara, Christian Honoré, Agata Wesolowska-Andersen, Anna L Gloyn, Mark I McCarthy, Mattias Hansson, Nicola L Beer, Martijn van de Bunt
AIMS/HYPOTHESIS: Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional studies have focused on the latter, given limitations regarding access to human fetal islet tissue. Capitalising upon advances in in vitro differentiation, we characterised the transcriptomes of human induced pluripotent stem cell (iPSC) lines differentiated along the pancreatic endocrine lineage, and explored the contribution of altered islet development to the pathogenesis of type 2 diabetes...
April 19, 2018: Diabetologia
https://www.readbyqxmd.com/read/29675256/a-case-with-relapsed-transient-neonatal-diabetes-mellitus-treated-with-sulfonylurea-ending-chronic-insulin-requirement
#10
Akihiko Ando, Shoichiro Nagasaka, Shun Ishibashi
We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8 -coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP ) channel protein. She was diagnosed with diabetes at 7 days after birth. After intravenous insulin drip for 1 month, her hyperglycaemia remitted. At the age of 13 years, her diabetes relapsed, and after that she had been treated by intensive insulin therapy for 25 years with relatively poor glycaemic control. She was switched to oral sulfonylurea therapy and attained euglycaemia...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29675042/genetic-variability-in-eif2-%C3%AE-gene-is-associated-with-islet-%C3%AE-cell-function-in-the-development-of-diabetes-in-a-chinese-han-population
#11
Nan Gu, Xiaowei Ma, Jianwei Zhang, Mengmeng Jin, Nan Feng, Ruifen Deng, Ge Bai, Hong Zhang, Xiaohui Guo
Aims: Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha ( eIF2α ) pathway mutations lead to failure of β -cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods: Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29674279/association-of-melatonin-mtnr1b-variants-with-type-2-diabetes-in-gujarat-population
#12
Roma Patel, Nirali Rathwa, Sayantani Pramanik Palit, A V Ramachandran, Rasheedunnisa Begum
AIM/HYPOTHESIS: Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of Melatonin Receptor 1B (MTNR1B) are reported to be associated with Type 2 Diabetes (T2D) susceptibility. The aim of the present study was to investigate i) plasma melatonin levels ii) Single Nucleotide Polymorphisms (SNPs) of MTNR1B and iii) Genotype-phenotype correlation analysis in T2D patients. METHODS: Plasma and PBMCs were separated from venous blood of 478 diabetes patients and 502 controls...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674003/tanshinone-iia-suppresses-fc%C3%AE%C2%B5ri-mediated-mast-cell-signaling-and-anaphylaxis-by-activation-of-the-sirt1-lkb1-ampk-pathway
#13
Xian Li, Soon Jin Park, Fansi Jin, Yifeng Deng, Ju Hye Yang, Jae-Hoon Chang, Dong-Young Kim, Jung-Ae Kim, Youn Ju Lee, Makoto Murakami, Kun Ho Son, Hyeun Wook Chang
AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1) and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently reported that the AMPK pathway negatively regulates mast cell activation and anaphylaxis. Tanshinone IIA (Tan IIA), an active component of Salvia miltiorrhiza extract that is currently used for the treatment of cardiovascular and cerebrovascular diseases, shows anti-diabetic activity and improves insulin resistance in db/db mice through activation of AMPK...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673926/the-investigations-of-genetic-determinants-of-the-metabolic-syndrome
#14
REVIEW
Behdokht Fathi Dizaji
Metabolic syndrome is the aggregation of cardiovascular risk factors that increases the risk of type 2 diabetes and cardiovascular diseases. Family and twin studies, heritability spectrum for its components and different prevalence among ethnicities, have provided genetic susceptibility to the metabolic syndrome. The investigations of genetic base for the disorder have recognized numerous chromosomes, various DNA polymorphisms in candidate genes and many gene variants, that are associated with metabolic syndrome as an entity or its traits, which mostly are related to lipid metabolism...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673860/the-endogenous-circadian-clock-programs-animals-to-eat-at-certain-times-of-the-24-hour-day-what-if-we-ignore-the-clock
#15
Peng Jiang, Fred W Turek
The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty years after this breakthrough, the biomedical community is now at a new frontier to incorporate the circadian clock mechanisms into many areas of biomedical research, as studies continue to reveal an important role of the circadian clock in a wide range of biological functions and diseases...
April 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29673546/interactions-among-the-variants-of-insulin-related-genes-and-nutrients-increase-the-risk-of-type-2-diabetes
#16
Kyung-Won Hong, Sung Hoon Kim, Xin Zhang, Sunmin Park
Asians easily develops type 2 diabetes (T2DM) since they have insufficient glucose-stimulated insulin secretion (GSIS) in insulin resistant states. Since this may be associated with genetic background, the hypothesis of this study was that inter-genetic and gene-nutrient interactions may explain the low insulin secretory capacity of Asians. Accordingly, we identified the best gene-gene and gene-nutrient interactions using generalized multifactor dimensionality reduction (GMDR) in a large Korean cohort (n=8,842)...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29673244/changes-in-body-composition-blood-lipid-profile-and-growth-factor-hormone-in-a-patient-with-prader-willi-syndrome-during-24-weeks-of-complex-exercise-a-single-case-study
#17
Hee Joung Joung, In Soo Lim
PURPOSE: Prader-Willi syndrome (PWS) is a genetic disorder characterized by excessive appetite with progressive obesity and growth hormone (GH) deficiency. Excessive eating causes progressive obesity with increased risk of morbidities and mortality. Although GH treatment has beneficial effects on patients with PWS, adverse events have occurred during GH treatment. Exercise potentially has a positive effect on obesity management. The purpose of this research was to examine the effects of 24-week complex exercise program on changes in body composition, blood lipid profiles, and growth factor hormone levels in a patient with PWS...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29673160/mechanisms-of-diabetes-induced-endothelial-cell-senescence-role-of-arginase-1
#18
Esraa Shosha, Zhimin Xu, S Priya Narayanan, Tahira Lemtalsi, Abdelrahman Y Fouda, Modesto Rojas, Ji Xing, David Fulton, R William Caldwell, Ruth B Caldwell
We have recently found that diabetes-induced premature senescence of retinal endothelial cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase enzyme arginase 1 (A1). Here, we used genetic strategies to determine the specific involvement of A1 in diabetes-induced endothelial cell senescence. We used A1 knockout mice and wild type mice that were rendered diabetic with streptozotocin and retinal endothelial cells (ECs) exposed to high glucose or transduced with adenovirus to overexpress A1 for these experiments...
April 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29671539/evaluation-of-suspected-dementia
#19
Nathan Falk, Ariel Cole, T Jason Meredith
Dementia is a significant and costly health condition that affects 5 million adults and is the fifth leading cause of death among Americans older than 65 years. The prevalence of dementia will likely increase in the future because the number of Americans older than 65 years is expected to double by 2060. Risk factors for dementia include age; family history of dementia; personal history of cardiovascular disease, cerebrovascular disease, diabetes mellitus, or midlife obesity; use of anticholinergic medications; apolipoprotein E4 genotype; and lower education level...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671100/pediatric-type-2-diabetes-in-japan-similarities-and-differences-from-type-2-diabetes-in-other-pediatric-populations
#20
REVIEW
Tatsuhiko Urakami
PURPOSE OF REVIEW: To review clinical characteristics of pediatric type 2 diabetes in Japan. RECENT FINDINGS: It is well recognized that Asian populations, particularly the Japanese, have a higher incidence of childhood type 2 diabetes. Of note, most Asian populations show a higher incidence of pediatric type 2 diabetes than that of type 1 diabetes. However, a current report in the USA demonstrated a dramatic increase in the incidence of young people with type 2 diabetes in recent years...
April 18, 2018: Current Diabetes Reports
keyword
keyword
85463
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"