Zhiqiang Pei, Jin Qiu, Yongchao Zhao, Shuai Song, Rui Wang, Wei Luo, Xingxing Cai, Bin Liu, Han Chen, Jiasheng Yin, Xinyu Weng, Yizhe Wu, Chenguang Li, Li Shen, Junbo Ge
BACKGROUND: Hypothermia therapy has been suggested to attenuate myocardial necrosis; however, the clinical implementation as a valid therapeutic strategy has failed, and new approaches are needed to translate into clinical applications. This study aimed to assess the feasibility, safety, and efficacy of a novel selective intracoronary hypothermia (SICH) device in mitigating myocardial reperfusion injury. METHODS: This study comprised two phases. The first phase of the SICH was performed in a normal porcine model for 30 minutes ( n = 5) to evaluate its feasibility...
March 6, 2024: Chinese Medical Journal