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https://www.readbyqxmd.com/read/29030064/five-year-major-clinical-outcomes-according-to-severity-of-coronary-artery-spasm-as-assessed-by-intracoronary-acetylcholine-provocation-test
#1
Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Byoung Geol Choi, Minsuk Shim, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Woohyeun Kim, Jun Hyuk Kang, Jah Yeon Choi, Eun Jin Park, Sung Hun Park, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Long-term clinical outcome data according to severity of coronary artery spasm (CAS) as assessed by an intracoronary acetylcholine provocation test are limited in series of Asian patients. AIM: To investigate 5-year clinical outcomes in patients with CAS according to CAS severity. METHODS: In total, 5873 consecutive patients with insignificant coronary artery disease (<70% fixed stenosis) who underwent an acetylcholine provocation test were enrolled and divided into four groups according to CAS severity during the acetylcholine provocation test: negative, borderline positive, moderately positive and severely positive...
October 10, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29028737/resting-pd-pa-and-haemodynamic-relevance-of-coronary-stenosis-as-evaluated-by-fractional-flow-reserve
#2
Giuseppe De Luca, Monica Verdoia, Lucia Barbieri, Paolo Marino, Harry Suryapranata
BACKGROUND: Fractional flow reserve (FFR) currently represents the gold standard in the evaluation of the haemodynamic relevance of coronary stenoses. However, both intracoronary and intravenous adenosine may be tolerated poorly by some patients. Therefore, considerable interest had been focused in the last few years on new adenosine-free indexes to define the haemodynamic relevance of coronary stenoses. So far, few data have been reported on resting Pd/Pa and its correlation with FFR as evaluated with high-dose intracoronary adenosine administration, which is the aim of the current study...
October 12, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29027116/effect-of-intracoronary-and-intravenous-melatonin-on-myocardial-salvage-index-in-patients-with-st-elevation-myocardial-infarction-a-randomized-placebo-controlled-trial
#3
Sarah Ekeloef, Natalie Halladin, Siv Fonnes, Svend Eggert Jensen, Tomas Zaremba, Jacob Rosenberg, Grete Jonsson, Jens Aarøe, Lærke Smidt Gasbjerg, Mette Marie Rosenkilde, Ismail Gögenur
Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55...
October 12, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29025747/uncoupling-protein-2-inhibits-myointimal-hyperplasia-in-preclinical-animal-models-of-vascular-injury
#4
Yan Zhang, Yaolei Zhang, Wei Li, Peijian Wang, Rui Gu, Yaxing Feng, Shujie Wei, Ke Peng, Yunrong Zhang, Linan Su, Qiang Wang, De Li, Dachun Yang, Wing Tak Wong, Yongjian Yang, Shuangtao Ma
BACKGROUND: Intracoronary stent restenosis, characterized by excessive smooth muscle cell (SMC) proliferation and myointimal hyperplasia, remains a clinical challenge. Mitochondrial membrane potential has been linked to the proliferative rate of SMCs. This study aimed to screen a critical gene regulating mitochondrial potential and to confirm its effects on myointimal formation in preclinical animal models. METHODS AND RESULTS: We performed transcriptome screening for genes differentially expressed in ligated versus unligated mouse carotid arteries...
October 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29021844/intracoronary-acetylcholine-application-as-a-possible-probe-inducing-j-waves-in-patients-with-early-repolarization-syndrome
#5
REVIEW
Toru Maruyama, Kazumasa Fujita, Kei Irie, Shouhei Moriyama, Mitsuhiro Fukata
Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS complex in a surface electrocardiogram. The J wave is attributed to the transmural voltage gradient at the early repolarization phase across the ventricular wall, which stems mainly from prominent transient outward current in the epicardium, but not in the endocardium...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29019475/orofacial-pain-associated-with-vasospastic-angina-a-case-report
#6
Makoto Adachi, Mio Hayashi, Tomonori Segawa, Takahiko Yamaki, Yasunori Muramatsu, Shinichiro Sumitomo
The primary symptom of ischemic heart disease is typically chest pain, but in some cases, this pain may radiate to the maxillofacial region. This article describes the case of a 44-year-old man with orofacial pain of cardiac origin. The patient was suspected to be suffering from cardiac disease by the oral and maxillofacial surgeon and was referred to a cardiologist, where he received a heart examination. The patient was diagnosed by means of cardiac catheterization as having coronary spastic angina. During catheterization, intracoronary ergonovine maleate induced orofacial pain that was almost the same in character and intensity as the patient's first episode...
October 10, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28993001/absence-of-adventitial-vasa-vasorum-formation-at-the-coronary-segment-with-myocardial-bridge-an-optical-coherence-tomography-study
#7
Kensuke Nishimiya, Yasuharu Matsumoto, Hongxin Wang, Zhonglie Piao, Kazuma Ohyama, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa
BACKGROUND: Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. In this study, we examined adventitial VV formation at the coronary segment with MB in humans using OCT...
October 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28989933/spontaneous-left-main-and-right-coronary-artery-spasm-in-a-patient-with-vasospastic-angina
#8
Analkumar Parikh, Thomas Paul Vacek
Coronary spasm is a well-documented, though rare, condition that can mimic myocardial infarction and is usually found in only a single vessel during an event. We describe the case of a 43-year-old male with past medical history of hypertension, hyperlipidemia, tobacco abuse, and with no known coronary disease. The patient developed chest pain 3 days postadmission for primary diagnosis of psychiatric disorder. The patient had a positive stress study with moderate reversible ischemia in the anterolateral region...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28984776/intralesional-versus-intracoronary-administration-of-glycoprotein-iib-iiia-inhibitors-during-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndromes-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Binjie Sun, Zhen Liu, Hongshan Yin, Tao Wang, Tao Chen, Sen Yang, Zhian Jiang
BACKGROUND: Glycoprotein IIb/IIIa inhibitors (GPIs) have been regarded as an adjuvant regimen to deal with no-reflow. However, whether intralesional (IL) administration of GPIs improves myocardial reperfusion without increasing bleeding in patients with acute coronary syndrome (ACS) compared with intracoronary (IC) administration has not been well addressed. Our meta-analysis aimed to evaluate the efficacy and safety of IL versus IC administration of GPIs for patients with ACS during percutaneous coronary intervention...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982647/multimodality-intracoronary-imaging-with-near-infrared-spectroscopy-and-intravascular-ultrasound-in-asymptomatic-individuals-with-high-calcium-scores
#10
Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28979905/the-role-of-intracoronary-imaging-in-acute-coronary-syndromes-oct-in-focus
#11
REVIEW
Ahmad Samir, Ahmed ElGuindy
Optical coherence tomography (OCT) has emerged as a powerful intravascular imaging modality in recent years. The introduction of frequency-domain OCT has simplified the procedure and enabled its safe utilisation in different clinical settings including acute coronary syndromes, where it can determine the mechanism of plaque disruption, thrombus burden, and guide percutaneous coronary intervention. In patients presenting with stent failure (stent thrombosis and instent restenosis), OCT can also be very useful in determining the underlying mechanism and guiding therapy thereafter...
December 30, 2016: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28974667/intracoronary-administration-of-thrombolysis-for-severe-coronary-artery-ectasia-presenting-as-an-acute-inferior-st-segment-elevation-myocardial-infarction
#12
Avadhesh Saraswat, Atifur Rahman, Ravinder Batra
We present a 75-year-old male with acute inferior ST-elevation myocardial infarction, severe coronary artery ectasia, and large thrombus burden in the right coronary artery to support the use of intracoronary thrombolysis as a second-line therapy for a large thrombus burden in primary percutaneous coronary intervention.
October 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28974665/embolization-of-a-large-intracoronary-thrombus-during-st-segment-elevation-myocardial-infarction
#13
Nathaniel R Smilowitz, Claudia Serrano-Gomez
Aspiration thrombectomy was performed to retrieve intact thrombus in a 69-year-old woman. Bradycardia and hypotension rapidly resolved. Balloon angioplasty was performed at the site of proximal RCA in-stent restenosis with improved angiographic appearance and TIMI 3 flow in the major branches.
October 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28958332/protein-phosphatase-inhibitor-1-gene%C3%A2-therapy-in-a-swine-model-of-nonischemic%C3%A2-heart-failure
#14
Shin Watanabe, Kiyotake Ishikawa, Kenneth Fish, Jae Gyun Oh, Lukas J Motloch, Erik Kohlbrenner, Philyoung Lee, Chaoqin Xie, Ahyoung Lee, Lifan Liang, Changwon Kho, Lauren Leonardson, Maritza McIntyre, Scott Wilson, R Jude Samulski, Evangelia G Kranias, Thomas Weber, Fadi G Akar, Roger J Hajjar
BACKGROUND: Increased protein phosphatase-1 in heart failure (HF) induces molecular changes deleterious to the cardiac cell. Inhibiting protein phosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardiac dysfunction in a model of ischemic HF. OBJECTIVES: This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated viral vector carrying I-1c (BNP116.I-1c) in a preclinical model of nonischemic HF, and to assess thoroughly the safety of BNP116...
October 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28948706/the-effect-of-intracoronary-infusion-of-bone-marrow-derived-mononuclear-cells-on-all-cause-mortality-in-acute-myocardial-infarction-rationale-and-design-of-the-bami-trial
#15
Anthony Mathur, Roman Arnold, Birgit Assmus, Jozef Bartunek, Ann Belmans, Halvard Bönig, Filippo Crea, Stefanie Dimmeler, Sheik Dowlut, Francisco Fernández-Avilés, Manuel Galiñanes, David Garcia-Dorado, Juha Hartikainen, Jonathan Hill, Annette Hogardt-Noll, Christian Homsy, Stefan Janssens, Petr Kala, Jens Kastrup, John Martin, Philippe Menasche, Roman Miklik, Abdul Mozid, J Alberto San Román, Ricardo Sanz-Ruiz, Michal Tendera, Wojtek Wojakowski, Seppo Ylä-Herttuala, Andreas Zeiher
Over the past 13 years bone marrow-derived mononuclear cells (BM-MNCs) have been widely investigated for clinical efficacy in patients following acute myocardial infarction (AMI). These early phase II trials have used various surrogate markers to judge efficacy and, although promising, the results have been inconsistent. The phase III BAMI trial has therefore been designed to demonstrate that intracoronary infusion of BM-MNCs is safe and will significantly reduce the time to first occurrence of all-cause death in patients with reduced left ventricular ejection fraction after successful reperfusion for ST-elevation AMI (powered with the aim of detecting a 25% reduction in all-cause mortality)...
September 25, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28944620/intracoronary-snaring-of-the-retrograde-guidewire-how-to-overcome-extreme-takeoff-angles-in-chronic-total-occlusion-percutaneous-coronary-intervention
#16
Lorenzo Azzalini, Luciano Candilio, Mauro Carlino, Antonio Colombo
Extreme angulation of coronary artery takeoff represents a challenge for wiring and device advancement in percutaneous coronary intervention (PCI). This anatomic feature is particularly adverse in cases of chronic total occlusion (CTO) of the ostial-proximal segment of the target vessel. In this setting, the retrograde approach can help getting access to the occlusion. However, difficulties might arise at the critical step of wire externalization, due to the need to overcome the extreme ostial angle. Here, we describe a case of successful CTO PCI of the proximal circumflex artery, which presented an extreme angle at its takeoff...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28940997/real-time-optical-coherence-tomography-coregistration-with-angiography-in-percutaneous-coronary-intervention-impact-on-physician-decision-making-the-optico-integration-study
#17
David M Leistner, Matthias Riedel, Lisa Steinbeck, Barbara E Stähli, Georg M Fröhlich, Alexander Lauten, Carsten Skurk, Hans-Christian Mochmann, Laura Lübking, Ursula Rauch-Kröhnert, Renate B Schnabel, Dirk Westermann, Stefan Blankenberg, Ulf Landmesser
AIMS: Intracoronary optical coherence tomography (OCT) imaging allows for high-resolution characterization of coronary lesions. Difficulties in matching cross-sectional OCT-images with angiographic lesion localization may limit optimal clinical utilization. We sought to prospectively assess the impact of a novel system of real-time OCT coregistration with angiography (ACR) on physician decision-making during percutaneous coronary interventions (PCI). METHODS AND RESULTS: Strategy for PCI (stent - length, - diameter, - strategy, landing zone) and PCI-optimization (stent-malappostion, -underexpansion, edge-dissections, geographical mismatch) was prospectively assessed in 50 patients with 58 coronary lesions after (I) angiography, (II) OCT imaging, and (III) ACR...
September 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28935079/effect-of-post-dilatation-following-primary-pci-with-everolimus-eluting-bioresorbable-scaffold-versus-everolimus-eluting-metallic-stent-implantation-an-angiographic-and-optical-coherence-tomography-trofi%C3%A2-ii%C3%A2-substudy
#18
Kyohei Yamaji, Salvatore Brugaletta, Manel Sabaté, Andrés Iñiguez, Lisette Okkels Jensen, Angel Cequier, Sjoerd H Hofma, Evald Høj Christiansen, Maarten Suttorp, Gerrit Anne van Es, Yohei Sotomi, Yoshinobu Onuma, Patrick W Serruys, Stephan Windecker, Lorenz Räber
OBJECTIVES: This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EES). BACKGROUND: Routine post-dilatation of BRS has been suggested to improve post-procedural angiographic and subsequent device-related clinical outcomes. METHODS: In the ABSORB STEMI TROFI II trial, 191 patients with ST-segment elevation myocardial infarction were randomly assigned to treatment with BRS (n = 95) or EES (n = 96)...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28935073/incidence-clinical-presentation-and-predictors-of-clinical-restenosis-in-coronary-bioresorbable-scaffolds
#19
Alberto Polimeni, Melissa Weissner, Katharina Schochlow, Helen Ullrich, Ciro Indolfi, Jouke Dijkstra, Remzi Anadol, Thomas Münzel, Tommaso Gori
OBJECTIVES: The aim of this study was to describe the incidence and clinical characteristics, including intracoronary imaging features, of clinical restenosis in bioresorbable coronary scaffolds (BRS). Further, the authors searched for clinical and procedural predictors of scaffold restenosis (ScR) and report on the clinical outcomes after treatment of ScR in a cohort of consecutive all-comer patients. BACKGROUND: Data from randomized controlled trials demonstrate a higher rate of target lesion failure in patients treated with BRS as compared with those treated with metal drug-eluting stents...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28924344/the-return-of-the-vulnerable-plaque-optical-coherence-tomography-imaging-of-a-case-of-a-late-in-stent-restenotic-chronic-total-occlusion
#20
Dilbahar S Mohar, Pranav M Patel, Alisha K Grewal, Prabhsimran Mohar, Morton J Kern
Although the use of drug-eluting stents (DES) has dramatically decreased the incidence of in-stent restenosis (ISR), concerns regarding the late manifestations of ISR remain. Optical coherence tomography (OCT) imaging provides unique insights into characteristics and patterns of ISR. We report a case of late DES ISR with unusual heterogeneous intracoronary luminal characteristics suggestive of vulnerable atherosclerotic plaque activity by OCT imaging. This case demonstrates that late ISR after DES may involve more than mere neointimal hyperplasia with lesion-associated craters, septae, and neoatherosclerosis...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
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