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https://www.readbyqxmd.com/read/28819899/significance-of-intravascular-ultrasound-and-exercise-stress-echocardiography-in-diagnosis-of-exercise-induced-vasospastic-angina-at-the-site-of-moderate-stenosis
#1
Makio Muraishi, Kentaro Shibayama, Masahiko Noguchi, Hiroyuki Watanabe, Kotaro Obunai
Recently, exercise-induced spastic coronary artery occlusion at the site of moderate stenosis, which Prinzmetal's angina or cardiac syndrome X does not cover, was reported. Multi-modality imaging is important for the diagnosis of coronary artery disease with a complex ischemic mechanism. However, the previous report did not include findings from intracoronary imaging at the site of moderate coronary stenosis. We report a case of exercise-induced vasospastic angina at the site of moderate stenosis, where multi-modality imaging, including exercise stress echocardiography and intravascular ultrasound, was utilized to make a definitive diagnosis and investigate underlying causes...
August 17, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28818410/optical-coherence-tomography-guided-percutaneous-coronary-intervention
#2
REVIEW
Francis J Ha, Joel P Giblett, Nitesh Nerlekar, James D Cameron, Ian T Meredith, Nick E J West, Adam J Brown
Optical coherence tomography (OCT) is an increasingly available intracoronary imaging modality that provides high-resolution imaging of coronary arteries. Its fundamental reliance on the emission and reflection of light enables rapid data acquisition without compromise of image resolution. As such, OCT can inform operators planning percutaneous coronary intervention (PCI) by accurately defining luminal geometry and detailing plaque composition. Following PCI, OCT imaging delivers a thorough assessment of the treated arterial segment and can identify specific features not always visible on alternate imaging modalities, including stent edge-related dissection, plaque tissue prolapse, incomplete stent apposition and the presence of intra-coronary thrombus...
August 4, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28811941/seizure-associated-takotsubo-syndrome-a-rare-combination
#3
Htay Htay Kyi, Nour Aljariri Alhesan, Sunil Upadhaya, Samer Al Hadidi
Takotsubo cardiomyopathy (TC) is increasingly recognized in neurocritical care population especially in postmenopausal females. We are presenting a 61-year-old African American female with past medical history of epilepsy, bipolar disorder, and hypertension who presented with multiple episodes of seizures due to noncompliance with antiepileptic medications. She was on telemetry which showed ST alarm. Electrocardiogram (ECG) was ordered and showed ST elevation in anterolateral leads and troponins were positive...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28809723/nitroglycerin-derived-pd-pa-for-the-assessment-of-intermediate-coronary-lesions
#4
Zeev Israeli, Rodrigo Bagur, Dorian Murariu, Sabrina Wall, Mistre Alemayehu, Yasir Parviz, Pantelis Diamantouros, Shahar Lavi
OBJECTIVES: To assess the predictive value of Pd/Pa after nitroglycerin administration (Pd/Pa[N]) as compared with standard fractional flow reserve (FFR). METHODS: Consecutive patients with intermediate coronary lesions assessed by FFR between January 2014 and October 2015 were included. We measured Pd/Pa at baseline, Pd/Pa(N), and Pd/Pa after incremental doses of intracoronary adenosine. RESULTS: A total of 134 patients (27% females; mean age, 65 years) were included...
August 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28801817/contour-segmentation-of-the-intima-media-and-adventitia-layers-in-intracoronary-oct-images-application-to-fully-automatic-detection-of-healthy-wall-regions
#5
Guillaume Zahnd, Ayla Hoogendoorn, Nicolas Combaret, Antonios Karanasos, Emilie Péry, Laurent Sarry, Pascal Motreff, Wiro Niessen, Evelyn Regar, Gijs van Soest, Frank Gijsen, Theo van Walsum
PURPOSE: Quantitative and automatic analysis of intracoronary optical coherence tomography images is useful and time-saving to assess cardiovascular risk in the clinical arena. METHODS: First, the interfaces of the intima, media, and adventitia layers are segmented, by means of an original front propagation scheme, running in a 4D multi-parametric space, to simultaneously extract three non-crossing contours in the initial cross-sectional image. Second, information resulting from the tentative contours is exploited by a machine learning approach to identify healthy and diseased regions of the arterial wall...
August 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28799978/role-of-fractional-flow-reserve-in-the-evaluation-and-management-of-patients-with-acute-coronary-syndrome
#6
Abdul Hakeem, Ahmed Almomani, Barry F Uretsky
PURPOSE OF REVIEW: The aim of this review is to appraise the clinical and prognostic value and pitfalls of FFR across different spectra of ACS presentations and lesion subsets. RECENT FINDINGS: Preponderance of evidence on this subject is from observational nonrandomized studies with conflicting results and short-term outcomes. Multiple recent studies evaluating the role of FFR-based deferral in non-STE ACS from a potentially culprit lesion have demonstrated poor long-term prognosis as related to future risk of target vessel failure (myocardial infarction/revascularization)...
August 10, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28792241/intracoronary-nitroglycerin-recognizing-coronary-spasm-first-and-foremost-to-avoid-unnecessary-coronary-stents
#7
Alec Vishnevsky, David L Fischman, Michael P Savage
No abstract text is available yet for this article.
August 17, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28780029/intracoronary-bubbles-iatrogenic-air-embolism-assessed-with-optical%C3%A2-coherence%C3%A2-tomography
#8
Ramón Maruri-Sánchez, Fernando Rivero, Teresa Bastante, Javier Cuesta, Marcos García-Guimaraes, Fernando Alfonso
No abstract text is available yet for this article.
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28765529/intracoronary-imaging-cholesterol-efflux-and-transcriptomics-after-intensive-statin-treatment-in-diabetes
#9
Surbhi Chamaria, Kipp W Johnson, Yuliya Vengrenyuk, Usman Baber, Khader Shameer, Aparna A Divaraniya, Benjamin S Glicksberg, Li Li, Samit Bhatheja, Pedro Moreno, Akiko Maehara, Roxana Mehran, Joel T Dudley, Jagat Narula, Samin K Sharma, Annapoorna S Kini
Residual atherothrombotic risk remains higher in patients with versus without diabetes mellitus (DM) despite statin therapy. The underlying mechanisms are unclear. This is a retrospective post-hoc analysis of the YELLOW II trial, comparing patients with and without DM (non-DM) who received rosuvastatin 40 mg for 8-12 weeks and underwent intracoronary multimodality imaging of an obstructive nonculprit lesion, before and after therapy. In addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene expression in peripheral blood mononuclear cells (PBMC)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764604/optical-coherence-tomography-to-guide-percutaneous-treatment-of-coronary-bifurcation-disease
#10
Mathias Wolfrum, Giovanni Luigi De Maria, Adrian P Banning
Cardiovascular disease remains the most common cause of death worldwide. Enormous progress in the technology and applicability of percutaneous techniques to treat obstructive coronary heart disease has been made, and the number of percutaneous coronary interventions (PCI) is increasing. Coronary bifurcations are involved in a substantial number of PCIs and despite recent advances, bifurcation PCI remains a challenge in terms of immediate success and long-term outcome. Angiography has a limited capacity for showing important features of the 3 dimensional coronary vessel anatomy, position of stent struts and exact wire positions and is therefore suboptimal for guiding bifurcation PCI...
August 9, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28762926/-giant-aneurisms-of-coronary-arteries-in-the-kawasaki-syndrome
#11
G A Lyskina, O L Bokeriya, O G Shirinskaya, N V Gagarina, A S Satyukova, A V Torbyak, Yu O Kostina
BACKGROUND: Kawasaki disease is an acute systemic vasculitis of childhood with possible coronary artery involvement which can cause acute coronary syndrome in children and young adults. PURPOSE: to study clinical and demographic characteristics of patients with Kawasaki disease with giant coronary aneurysms, to assess long-term prognosis in these patients. MATERIAL AND METHODS: In 2003-2015 262 children with Kawasaki disease were examined in the University Children Hospital of the I...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761388/coronary-stents-and-vascular-response-to-implantation-literature-review
#12
REVIEW
Marta Francesca Brancati, Francesco Burzotta, Carlo Trani, Ornella Leonzi, Claudio Cuccia, Filippo Crea
Drug-eluting stents (DESs) have minimized the limitations of bare-metal stents (BMSs) after percutaneous coronary interventions. Nevertheless, serious concerns remain about possible late complications of stenting, such as stent thrombosis (ST) and in-stent restenosis (ISR), although the introduction of second-generation DESs seems to have softened the phenomenon, compared to the first-generation ones. ST is a potentially catastrophic event, which has been markedly reduced by optimization of stent implantation, novel stent designs, and dual antiplatelet therapy...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28760202/high-sensitivity-c-reactive-protein-is-an-independent-marker-of-abnormal-coronary-vasoreactivity-in-patients-with-non-obstructive-coronary-artery-disease
#13
Jaskanwal D S Sara, Megha Prasad, Ming Zhang, Ryan J Lennon, Joerg Herrmann, Lilach O Lerman, Amir Lerman
BACKGROUND: Coronary endothelial dysfunction (CED) is an early stage of atherosclerosis and is associated with adverse cardiovascular events. Inflammation may play a role in the development of endothelial dysfunction. To date no study has evaluated the relationship between C-reactive protein and CED. We aimed to determine if C-reactive protein is associated with CED. METHODS: In 1016 patients (mean age 50.7±12.3 years, 34% male) presenting to the catheterization laboratory with chest pain and non-obstructive coronary artery disease, coronary vasoreactivity was assessed by measuring the percent change in coronary blood flow (%ΔCBF) and coronary artery diameter (%ΔCAD) in response to intracoronary acetylcholine...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28756427/thrombolysis-a-useful-tool-in-the-primary-pci-cupboard
#14
Konstantin Schwarz, Deepak Goyal, Helen Routledge
A 44-year-old woman presented to the emergency department with central crushing chest pain and dynamic anterior ST elevation on a background of a known left bundle-branch block on her electrocardiogram. Past medical history included insulin-dependent diabetes, asthma, fibromyalgia, and a gradually failing kidney transplant. This case demonstrates the rarely utilized niche role for intracoronary thrombolysis in STEMI treatment in the modern angioplasty era.
August 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28754718/intracoronary-delivery-of-recombinant-timp-3-following-myocardial-infarction-effects-on-myocardial-remodeling-and-function
#15
Shayne C Barlow, Heather Doviak, Julia Jacobs, Lisa A Freeburg, Paige E Perreault, Kia N Zellars, Karen Moreau, Camila F Villacreses, Stephen Smith, Aarif F Khakoo, TaeWeon Lee, Francis G Spinale
BACKGROUND AND SIGNIFICANCE: Ischemia-reperfusion and myocardial infarction causes adverse LV remodeling and heart failure, facilitated by an imbalance in matrix metalloproteinase activation and the endogenous tissue inhibitors of MMPs. We identified that myocardial injections of a recombinant TIMP-3 (human full length) can interrupt post-MI remodeling. However, to what degree intracoronary delivery of rTIMP-3 post-IR is feasible and effective remained to be established. METHODS AND RESULTS: Pigs (25 kg) underwent coronary catheterization and balloon occlusion of the left anterior descending for 90 minutes whereby at the final 4 minutes, rTIMP-3 (n=9; 30 mg) or saline was infused in the distal LAD...
July 28, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28752730/edge-effect-after-intracoronary-beta-radiation-brachytherapy-and-bare-metal-stent-implantation-the-pathway-for-very-late-stent-failure
#16
Mariano Pellicano, Vincent Floré, Angela Ferrara, Julien Adjedj, Emanuele Barbato, William Wijns
No abstract text is available yet for this article.
July 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28751570/association-of-coronary-perivascular-adipose-tissue-inflammation-and-drug-eluting-stent-induced-coronary-hyperconstricting-responses-in-pigs-18-f-fluorodeoxyglucose-positron-emission-tomography-imaging-study
#17
Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Satoshi Miyata, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa
OBJECTIVE: Although coronary perivascular adipose tissue (PVAT) may play important roles as a source of inflammation, the association of coronary PVAT inflammation and coronary hyperconstricting responses remains to be examined. We addressed this important issue in a porcine model of coronary hyperconstricting responses after drug-eluting stent implantation with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomographic imaging. APPROACH AND RESULTS: An everolimus-eluting stent (EES) was randomly implanted in pigs into the left anterior descending or the left circumflex coronary artery while nonstented coronary artery was used as a control...
July 27, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28747040/glycative-and-oxidative-stress-are-associated-with-altered-thrombus-composition-in-diabetic-patients-with-st-elevation-myocardial-infarction
#18
Antonia Sambola, Marisol Ruiz-Meana, Ignasi Barba, Bruno García Del Blanco, José A Barrabés, G Y Lip, Úrsula Vilardosa, Sara Sansaloni, Pau Rello, David García-Dorado
BACKGROUND: The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI). AIMS: To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the potential association of these differences with glycated haemoglobin levels and markers of oxidative stress. METHODS: Intracoronary thrombi from consecutive thrombus aspiration procedures in STEMI patients, 25 diabetic and 28 non-diabetic, were analyzed by immunofluorescence with confocal microscopy...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28733995/incidence-predictors-and-clinical-outcomes-of-early-stent-thrombosis-in-acute-myocardial-infarction-patients-treated-with-primary-percutaneous-coronary-angioplasty-insights-from-the-university-of-ottawa-heart-institute-stemi-registry
#19
Kuljit Singh, Mohammed Rashid, Derek Y So, Christopher A Glover, Michael Froeschl, Benjamin Hibbert, Aun-Yeong Chong, Alexander Dick, Marino Labinaz, Michel Le May
BACKGROUND: Early stent thrombosis (ST) remains an important complication of primary percutaneous intervention (PCI). To date, our information on angiographic and clinical predictors of early ST in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI is limited. METHODS: We tried to evaluate the incidence, predictors, and outcomes of early ST in real-world patients treated with primary PCI. We identified all the patients presenting with STEMI between June 2004 and January 2011 who underwent primary PCI as the primary mode of revascularization...
July 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28732349/intracoronary-administration-of-tirofiban-during-percutaneous-coronary-intervention-facilitates-patients-with-acute-coronary-syndrome
#20
Helei Jia, Changqing Lu, Panli Sun
We assessed the efficacy and safety of tirofiban intracoronary versus intravenous administration during percutaneous coronary intervention for patients with acute coronary syndrome. The databases of PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang Database were retrieved. A total of 437 articles were found, according to inclusive and exclusive criteria, 13 of which were finally included. Compared with subjects with intravenous administration, those with intracoronary administration were more likely to reach thrombolysis in myocardial infarction trial grade 3 flow (relative risk = 1...
July 12, 2017: Oncotarget
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