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Shohei Kishi, Koichi Fuse, Hitoshi Kitazawa, Takao Sato, Msaaki Okabe, Yoshifusa Aizawa
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June 2018: HeartRhythm Case Reports
Hiroki Shibutani, Yuzo Akita, Yohei Oishi, Hiroyuki Sueyoshi, Yu Mukai, Kotaro Yutaka, Yumie Matsui, Masahiro Yoshinaga, Masahiro Karakawa
BACKGROUND: A new complication, longitudinal stent deformation (LSD), is increasingly reported with recent intracoronary stent designs. We experienced unusual cases of distal LSD caused by entrapment of a Lacrosse® non-slip element (NSE) balloon (Goodman Co., Ltd., Nagoya, Japan), which comes with three flexible nylon elements to prevent slippage. Accordingly, the aim of this study is to report the clinical experience of distal LSD caused by the NSE in our center and to investigate the incidence and mechanisms involved...
June 20, 2018: Cardiology Journal
Francisco Fernández-Avilés, Ricardo Sanz-Ruiz, Jan Bogaert, Ana Casado Plasencia, Inmaculada Gilaberte, Ann Belmans, María Eugenia Fernández-Santos, Dominique Charron, Miguel Mulet, Raquel Yotti, Itziar Palacios, Manuel Luque, Rafael Sádaba, J A San Roman, Mariano Larman, Pedro L Sánchez, Juan Sanchis, Manuel F Jimenez-Navarro, Piet Claus, Reem Al-Daccak, Eleuterio Lombardo, José Luis Abad, Olga Delarosa, Lucia Corcostegui, Javier Bermejo, Stefan Janssens
<u>Rationale:</u> Allogeneic cardiac stem cells (AlloCSC-01) have shown protective, immunoregulatory and regenerative properties with a robust safety profile in large animal models of heart disease. <u>Objective:</u> To investigate the safety and feasibility of early administration of AlloCSC-01 in patients with ST-segment elevation myocardial infarction (STEMI). <u>Methods and Results:</u> CAREMI was a phase I/II multicenter, randomized, double-blind, placebo-controlled trial in patients with STEMI, LVEF ≤ 45% and infarct size ≥ 25% of left ventricular (LV) mass by cardiac magnetic resonance (MR), who were randomized (2:1) to receive AlloCSC-01 or placebo through the intracoronary route at day 5-7...
June 19, 2018: Circulation Research
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
Shigeki Kimura, Tomoyo Sugiyama, Keiichi Hishikari, Shun Nakagama, Shun Nakamura, Toru Misawa, Masafumi Mizusawa, Kazuto Hayasaka, Yosuke Yamakami, Yuichiro Sagawa, Keisuke Kojima, Hirofumi Ohtani, Hiroyuki Hikita, Atsushi Takahashi
BACKGROUND: The in vivo lesion morphologies and plaque components of coronary chronic total occlusion (CTO) lesions remain unclear.Methods and Results:We investigated 57 consecutive CTO lesions in 57 patients with stable angina pectoris undergoing elective percutaneous coronary intervention with intravascular ultrasound (IVUS) and coronary angioscopy (CAS) examination. All CTO lesions were classified according to the proximal angiographic lumen pattern; tapered-type (T-CTO) and abrupt-type (A-CTO)...
June 15, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Giuseppe Tarantini, Alberto Barioli, Luca Nai Fovino, Chiara Fraccaro, Giulia Masiero, Sabino Iliceto, Massimo Napodano
BACKGROUND: Invasive physiological assessment of myocardial bridges (MBs) is largely unsettled. Unlike fractional flow reserve (FFR), instantaneous wave-free ratio (iFR) is a diastole-specific index. As such, its value might not be hampered by systolic pressure overshooting and negative systolic pressure gradient caused by the compression of the tunneled coronary artery. METHODS AND RESULTS: We prospectively enrolled 20 patients with angina and/or positive noninvasive stress test, absence of significant coronary artery stenosis, and angiographic suspicion/evidence of MB in the left anterior descending artery...
June 2018: Circulation. Cardiovascular Interventions
Georgios Sideris, Nikolaos Magkoutis, Sebastian Voicu, Chantal Kang, Michel Bonneau, Demetris Yannopoulos, Claire Bal Dit Sollier, Jean-Guillaume Dillinger, Natacha Berge, Philippe Brouland, Patrick Henry, Ludovic Drouet
AIMS: We sought to develop a reproducible animal model for acute myocardial infarction (AMI) in adult atherosclerosis-prone pigs. METHODS AND RESULTS: A coil was placed in the right coronary artery or the left anterior descending artery in 26 downsized spontaneously hypercholesterolemic pigs and left untreated until thrombotic occlusion. Then, we crossed the thrombotic occlusion with a guidewire, followed by pre-dilatation, thrombus visualization with Optical Coherence Tomography (OCT) imaging and, finally, deployment of a stent and repeated OCT...
June 12, 2018: EuroIntervention
Noel M Caplice, Mary C DeVoe, Janet Choi, Darren Dahly, Theodore Murphy, Ernest Spitzer, Robert Van Geuns, Michael M Maher, David Tuite, David M Kerins, Mohammed T Ali, Imtiaz Kalyar, Eoin F Fahy, Wisam Khider, Peter Kelly, Peter P Kearney, Ronan J Curtin, Conor O'Shea, Carl J Vaughan, Joseph A Eustace, Eugene P McFadden
BACKGROUND: Residual and significant postinfarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), remains an important clinical issue. In preclinical models, low-dose insulin-like growth factor 1 (IGF1) has potent cytoprotective and positive cardiac remodeling effects. We studied the safety and efficacy of immediate post-PCI low-dose intracoronary IGF1 infusion in STEMI patients...
June 2018: American Heart Journal
WenHua Li, SongQi Guo, Shu Wang, Xin Sun, ZhuQin Li, XinYong Sun, YanMing Sun, LanFeng Wang, Wei Pan
PURPOSE: This study aimed to explore the effects of ticagrelor (a P2Y12 receptor inhibitor) on interleukin (IL)-17 and myeloperoxidase (MPO) expression in coronary thrombus as well as on the coronary blood flow in ST-segment elevation myocardial infarction (STEMI) patients following percutaneous coronary intervention (PCI). METHODS: Forty STEMI patients who were admitted to the First Affiliated Hospital of Harbin Medical University between August 1, 2014 and December 30, 2014 were enrolled in this study according to a set inclusion criteria...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Chunguang Feng, Yi Liu, Lulu Wang, Dongdong Niu, Bing Han
BACKGROUND: To determine whether nicorandil administration distal to the thrombus in the coronary artery during percutaneous coronary intervention (PCI) in acute ST-segment elevation myocardial infarction (STEMI) patients reduced the incidence of no-reflow phenomenon, reperfusion injury, and adverse events. METHODS: This randomised controlled trial involved 170 STEMI patients who underwent PCI. All patients underwent thrombectomy and tirofiban injection (10μg/kg) distal to the vascular lesion via a suction catheter, followed by nicorandil (84 patients; 2mg) or saline injection (86 patients; 2mL) at the same site...
May 22, 2018: Heart, Lung & Circulation
Daniel A Jones, Krishnaraj S Rathod, Anna Williamson, Deirdre Harrington, Mervyn Andiapen, Sven van Eijl, Mark Westwood, Sotiris Antoniou, Richard J Schilling, Amrita Ahluwalia, Anthony Mathur
OBJECTIVE: Pre-clinical evidence suggests delivery of nitric oxide (NO) through administration of inorganic nitrite suppresses arrhythmias resulting from acute ischaemia and reperfusion (I/R). To date no assessment of whether inorganic nitrite might limit reperfusion arrhythmia has occurred in man, therefore we explored the effects on I/R-induced ventricular arrhythmias in the NITRITE-AMI cohort. METHODS: In the NITRITE-AMI cohort, Holter analysis was performed prior to and for 24 h after primary PCI in 80 patients who received either intra-coronary sodium nitrite (N = 40) or placebo (N = 40) during primary PCI for AMI...
September 1, 2018: International Journal of Cardiology
Jingyi Zhang, Li Lin, Wenxia Zong
PURPOSE: Results on the clinical utility of cell therapy for ST-elevated myocardial infarction (STEMI) are controversial. This study sought to analyze the efficacy of treatment with intracoronary bone marrow mononuclear cells (BMMC) on left ventricular (LV) function and remodeling and LV diastolic and systolic function in patients with STEMI. MATERIALS AND METHODS: Literature search of PubMed and EMBASE databases between 2004 and 2017 was performed for randomized controlled trials in STEMI patients who underwent successful percutaneous coronary intervention and received intracoronary BMMC therapy...
July 2018: Yonsei Medical Journal
Aiko Shimokado, Yoshiki Matsuo, Takashi Kubo, Tsuyoshi Nishiguchi, Akira Taruya, Ikuko Teraguchi, Yasutsugu Shiono, Makoto Orii, Takashi Tanimoto, Takashi Yamano, Yasushi Ino, Takeshi Hozumi, Atsushi Tanaka, Yasuteru Muragaki, Takashi Akasaka
BACKGROUND AND AIMS: The aim of this study was to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo, and to evaluate the prevalence and characteristics of HCPs in vivo. METHODS: Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with ≥50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT for HCPs (OCT-derived HCPs); the remaining 114 pairs were used to evaluate the accuracy of OCT in detecting histologically-defined HCPs...
May 21, 2018: Atherosclerosis
Ying Shen, Zhen Kun Yang, Jian Hu, Xiao Qun Wang, Yang Dai, Su Zhang, Rui Yan Zhang, Lin Lu, Feng Hua Ding, Wei Feng Shen
BACKGROUND: We investigated whether and to what extent stenosis of predominant collateral donor artery (PCDA) affects coronary collateral flow in relation to blood pressure (BP) in type 2 diabetic patients with chronic total occlusion (CTO). METHODS: Collateral flow index (CFI) as derived from intracoronary pressure distal to occluded segment and mean aortic pressure in 220 type 2 diabetic patients and 220 propensity score matched non-diabetic controls undergoing percutaneous coronary intervention for CTO...
June 1, 2018: Cardiovascular Diabetology
Vincent Spagnoli, Fabien Picard, Victor-Xavier Tadros, Daniel Cournoyer, Serge Doucet, Jean François Tanguay, Gilbert Gosselin, Pierre de Guise, Richard Gallo
Background: Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR). Methods: Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0...
April 2018: Cardiovascular Diagnosis and Therapy
Thomas J Ford, David Corcoran, Keith G Oldroyd, Margaret McEntegart, Paul Rocchiccioli, Stuart Watkins, Katriona Brooksbank, Sandosh Padmanabhan, Naveed Sattar, Andrew Briggs, Alex McConnachie, Rhian Touyz, Colin Berry
BACKGROUND: Coronary angiography is performed to assess for obstructive coronary artery disease (CAD), but "nonobstructive CAD" is a common finding. Microvascular or vasospastic angina may be relevant, but routine confirmatory testing is not evidence based and thus rarely performed. AIM: The aim was to assess the effect of stratified medicine guided by coronary function testing on the diagnosis, treatment, and well-being of patients with angina and nonobstructive CAD...
April 3, 2018: American Heart Journal
Bhupinder Singh, Abhishek Goyal, Bishav Mohan, Shibba Takkar Chhabra, Naved Aslam, Gurpreet Singh Wander
Angiogram of the right coronary artery was used to reveal a subtotal occlusion abutting the proximal end of the stent with TIMI I flow that responded quickly to intracoronary nitrates. The patient was diagnosed with vasospastic angina.
June 2018: Journal of Invasive Cardiology
Sigan Hu, Hongju Wang, Jian Zhu, Miaonan Li, Hui Li, Dasheng Gao, Heng Zhang
The aim of this study was to compare the efficacy and safety of 2 approaches for intra-coronary administration of tirofiban (aspiration catheter versus guiding catheter) in patients over 60 years of age undergoing percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). It has been suggested that the administration of tirofiban by intra-coronary injection could promote drug absorption in the diseased region and enhance the inhibition of platelet aggregation, decreasing bleeding rates, but little is known about the comparative efficiency and safety of using guiding catheter versus aspiration catheter for delivery...
May 2018: Medicine (Baltimore)
Lorenz Räber, Gary S Mintz, Konstantinos C Koskinas, Thomas W Johnson, Niels R Holm, Yoshinubo Onuma, Maria D Radu, Michael Joner, Bo Yu, Haibo Jia, Nicolas Menevau, Jose M de la Torre Hernandez, Javier Escaned, Jonathan Hill, Francesco Prati, Antonio Colombo, Carlo di Mario, Evelyn Regar, Davide Capodanno, William Wijns, Robert A Byrne, Giulio Guagliumi
This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified...
May 22, 2018: European Heart Journal
William F Penny, Timothy D Henry, Matthew W Watkins, Amit N Patel, H Kirk Hammond
The prognosis of patients with HFrEF remains poor despite the use of current medical and device therapies. Preclinical studies of HFrEF using IC delivery of RT-100, a replication deficient, E1/E3-deleted human adenovirus 5 encoding human AC6 was associated with favorable effects on LV function and remodeling. A recent multicenter, double-blind, placebo-controlled, phase 2 study demonstrated the safety of IC delivery of RT-100 in HFrEF patients and potential efficacy at the higher doses. This phase 2 dose finding study, which included doses not expected to be effective, identified a potential reduction in congestive heart failure admissions in the AC6-treated group one year after randomization...
April 6, 2018: American Heart Journal
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