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https://www.readbyqxmd.com/read/29435640/feasibility-and-safety-of-outpatient-cardiac-catheterization-with-intracoronary-acetylcholine-provocation-test
#1
Yuichi Saito, Hideki Kitahara, Toshihiro Shoji, Satoshi Tokimasa, Takashi Nakayama, Kazumasa Sugimoto, Yoshihide Fujimoto, Yoshio Kobayashi
Intracoronary acetylcholine (ACh) provocation test is useful to diagnose vasospastic angina. Although outpatient coronary angiography has been widely performed in current clinical settings, the feasibility and safety of ACh provocation test in outpatient services are unclear. A total of 323 patients, who electively underwent ACh provocation test in hospitalization and outpatient services, were included. Coronary angiography was performed after insertion of a temporary pacing electrode in the right ventricle...
February 12, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29434132/usefulness-of-cutting-balloon-angioplasty-prior-to-stenting-with-intravascular-ultrasound-imaging-guidance-for-spontaneous-multi-vessel-coronary-dissection-including-the-left-main-coronary-artery
#2
Masahiko Noguchi, Kotaro Obunai, Yu Fukui, Hiroshi Okumura, Hiroyuki Watanabe
We report a case of percutaneous coronary intervention for spontaneous multi-vessel coronary dissection including the left main coronary artery. This case suggests that intracoronary imaging is useful for understanding the complex anatomy and for choosing the appropriate management for effective revascularization. Furthermore, cutting balloon angioplasty prior to stenting is useful for preventing the longitudinal extension of the intramural hematoma and avoiding unnecessary stent implantation.
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29431053/nanoparticle-mediated-cell-capture-enables-rapid-endothelialization-of-a-novel-bare-metal-stent
#3
Brandon J Tefft, Susheil Uthamaraj, Adriana Harbuzariu, Jonathan Harburn, Tyra A Witt, Brant Newman, Peter J Psaltis, Ota Hlinomaz, David R Holmes, Rajiv Gulati, Robert D Simari, Dan Dragomir-Daescu, Gurpreet S Sandhu
Incomplete endothelialization of intracoronary stents has been associated with stent thrombosis and recurrent symptoms, whereas prolonged use of dual antiplatelet therapy increases bleeding related adverse events. Facilitated endothelialization has the potential to improve clinical outcomes in patients who are unable to tolerate dual antiplatelet therapy. The objective of this study is to demonstrate the feasibility of magnetic cell capture to rapidly endothelialize intracoronary stents in a large animal model...
February 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29422264/perilipin-2-levels-are-increased-in-patients-with-in-stent-neoatherosclerosis-a-clue-to-mechanisms-of-accelerated-plaque-formation-after-drug-eluting-stent-implantation
#4
Giampaolo Niccoli, Domenico D'Amario, Josip A Borovac, Erminio Santangelo, Giancarla Scalone, Francesco Fracassi, Rocco Vergallo, Vincenzo Vetrugno, Giorgia Copponi, Anna Severino, Giovanna Liuzzo, Asiia Imaeva, Andrea Siracusano, Filippo Crea
BACKGROUND: Perilipin 2 (PLIN2) is a protein that potentially facilitates atherogenesis in native coronary arteries or arteries with an implanted drug-eluting stent (DES). The aim of the study was to determine PLIN2 protein levels in peripheral monocytes of enrolled subjects and compare them between patients with native coronary artery disease (CAD) and those with an in-stent restenosis (ISR) due to neoatherosclerosis occurring >1 year after DES implantation. METHODS: Forty-two patients were prospectively enrolled in the study in 3:1 fashion and underwent coronary catheterization...
February 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407892/the-impact-of-myocardial-bridge-on-coronary-artery-spasm-and-long-term-clinical-outcomes-in-patients-without-significant-atherosclerotic-stenosis
#5
Purumeh Nam, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND AND AIMS: Myocardial bridge (MB) and coronary artery spasm (CAS) can induce a sustained chest pain, acute coronary syndrome (ACS) and even sudden cardiac death. The aim of this study is to evaluate the relationship between MB and CAS and its impact on long-term clinical outcomes. METHODS: A total of 812 patients with MB without significant coronary artery disease (CAD), who underwent acetylcholine (ACH) provocation test, were enrolled. Significant CAS was defined as ≥70% temporary narrowing by ACH test, and MB was defined as the characteristic phasic systolic compression of the coronary artery with a decrease of more than 30% in diameter on the angiogram after intracoronary nitroglycerin infusion...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29402957/selective-inhibition-of-succinate-dehydrogenase-in-reperfused-myocardium-with-intracoronary-malonate-reduces-infarct-size
#6
Laura Valls-Lacalle, Ignasi Barba, Elisabet Miró-Casas, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, David García-Dorado
Inhibition of succinate dehydrogenase (SDH) with malonate during reperfusion reduces infarct size in isolated mice hearts submitted to global ischemia. However, malonate has toxic effects that preclude its systemic administration in animals. Here we investigated the effect of intracoronary malonate on infarct size in pigs submitted to transient coronary occlusion. Under baseline conditions, 50 mmol/L of intracoronary disodium malonate, but not lower concentrations, transiently reduced systolic segment shortening in the region perfused by the left anterior descending coronary artery (LAD) in open-chest pigs...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29398450/changes-of-electrocardiogram-and-hemodynamics-in-response-to-dipyridamole-in%C3%A2-vivo-comparative-analyses-using-anesthetized-beagle-dogs-and-microminipigs
#7
Kentaro Ando, Akira Takahara, Yuji Nakamura, Takeshi Wada, Koki Chiba, Ai Goto, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kiyotaka Hoshiai, Yasuki Akie, Atsuhiko T Naito, Atsushi Sugiyama
Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and compared the results. Dipyridamole in doses of 0.056 and 0.56 mg/kg were intravenously infused over 10 min (n = 4 for each animal). Dipyridamole decreased the systolic/diastolic blood pressures and double product in dogs as well as in microminipigs; but it did not significantly alter the heart rate or the global balance between the myocardial oxygen demand and supply in either animal...
February 1, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29393600/temporal-trends-in-frequency-management-and-outcomes-of-coronary-perforations
#8
Agustín Fernández-Cisnal, Rafael Romaguera, Marcos Ñato, Josep Gómez-Lara, José L Ferreiro, Luis Teruel, Gerard Roura, Guillem Muntané-Carol, José González-Costello, Francisco Jacobi, Montserrat Gracida, Joan A Gómez-Hospital, Ángel Cequier
BACKGROUND: Coronary perforations (CP) have been described as a rare but potentially fatal complication in percutaneous coronary interventions (PCI). Our aim is to compare temporal trends in frequency, management and outcomes of coronary perforations (CP). METHODS: All cases of CP recorded in our prospective institutional percutaneous coronary intervention (PCI) registry from 2003 to 2015 were included. Patients were divided in 2 groups according to the time frame in which the CP occurred: the early period (before 2009, when the chronic total occlusions and primary PCI programs started) and the current period...
February 1, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29392974/rf-energized-intracoronary-guidewire-to-enhance-bipolar-ablation-of-the-interventricular-septum-in-silico-feasibility-study
#9
Juan J Pérez, Ana González-Suárez, Andre d'Avila, Enrique Berjano
PURPOSE: Although bipolar radiofrequency (RF) ablation (RFA) is broadly used to eliminate ventricular tachycardias in the interventricular septum wall, it can fail to create transmural lesions in thick ventricular walls. To solve this problem, we explored whether an RF-energized guidewire inserted into the ventricular wall would enhance bipolar RFA in the creation of transmural lesions through the ventricular wall. METHODS: We built three-dimensional computational models including two irrigated electrodes placed on opposing sides of the interventricular septum and a metal guidewire inserted into the septum...
February 2, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29392536/retrograde-coronary-venous-infusion-as-a-delivery-strategy-in-regenerative-cardiac-therapy-an-overview-of-preclinical-and-clinical-data
#10
REVIEW
Wouter A Gathier, Dirk Jan van Ginkel, Mira van der Naald, Frebus J van Slochteren, Pieter A Doevendans, Steven A J Chamuleau
An important aspect of cell therapy in the field of cardiac disease is safe and effective delivery of cells. Commonly used delivery strategies such as intramyocardial injection and intracoronary infusion both present with advantages and disadvantages. Therefore, alternative delivery routes are explored, such as retrograde coronary venous infusion (RCVI). Our aim is to evaluate safety and efficiency of RCVI by providing a complete overview of preclinical and clinical studies applying RCVI in a broad range of disease types and experimental models...
February 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29376402/cost-assessment-of-treatment-of-acute-myocardial-infarction-and-angiographically-visible-coronary-thrombus
#11
Katarzyna Pigoń, Edyta Nowak-Radzik, Tomasz Młyńczak, Grzegorz Banasik, Ewa Nowalany-Kozielska, Andrzej Tomasik
AIM: Study was aimed to assess the real-world costs of manual thrombectomy (MT) in selected ST segment-elevation myocardial infarction patients with intracoronary thrombus (IT). METHODS: Study group (IT+) comprised 51 patients with MT applied and control group (IT-) comprised 56 patients without IT who underwent angioplasty alone. Costs comprised hospital care and cost of disposable materials used during primary angioplasty. RESULTS: Complex management of patients with IT is more expensive, though allows to achieve clinical outcomes comparable to low-risk ST segment-elevation myocardial infarction patients without IT...
January 29, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29367514/intravascular-ultrasound-derived-virtual-fractional-flow-reserve-for-the-assessment-of-myocardial-ischemia
#12
Fumiyasu Seike, Teruyoshi Uetani, Kazuhisa Nishimura, Hiroshi Kawakami, Haruhiko Higashi, Akira Fujii, Jun Aono, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Shinji Inaba, Takafumi Okura, Kazunori Yasuda, Jitsuo Higaki, Shuntaro Ikeda
BACKGROUND: Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Intravascular ultrasound (IVUS) is an intracoronary imaging method that provides information about lumen and vessel morphology. Previous studies on the expanded use of IVUS to identify functional ischemia have noted an association between anatomy and physiology, but IVUS-derived minimum lumen area (MLA) has a weak-moderate correlation with myocardial ischemia compared with FFR. We developed a method to calculate FFR using IVUS-derived anatomical information for the assessment of myocardial ischemia...
January 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29367212/impact-of-cardiac-progenitor-cells-on-heart-failure-and-survival-in-single-ventricle-congenital-heart-disease
#13
Toshikazu Sano, Daiki Ousaka, Takuya Goto, Shuta Ishigami, Kenta Hirai, Shingo Kasahara, Shinichi Ohtsuki, Shunji Sano, Hidemasa Oh
Rationale: Intracoronary administration of cardiosphere-derived cells (CDCs) in patients with single ventricles resulted in a short-term improvement in cardiac function. Objective: To test the hypothesis that CDC infusion is associated with improved cardiac function and reduced mortality in patients with heart failure. Methods and Results: We evaluated the effectiveness of CDCs using an integrated cohort study in 101 patients with single ventricles, including 41 patients that received CDC infusion and 60 controls treated with staged palliation alone...
January 24, 2018: Circulation Research
https://www.readbyqxmd.com/read/29360941/utility-of-intracoronary-imaging-in-the-cardiac-catheterization-laboratory-comprehensive-evaluation-with-intravascular-ultrasound-and-optical-coherence-tomography
#14
Yasir Parviz, Evan Shlofmitz, Khady N Fall, Maayan Konigstein, Akiko Maehara, Allen Jeremias, Richard A Shlofmitz, Gary S Mintz, Ziad A Ali
Background: Intracoronary imaging is an important tool for guiding decision making in the cardiac catheterization laboratory. Sources of data: We have reviewed the latest available evidence in the field to highlight the various potential benefits of intravascular imaging. Areas of agreement: Coronary angiography has been considered the gold standard test to appropriately diagnose and manage patients with coronary artery disease, but it has the inherent limitation of being a 2-dimensional x-ray lumenogram of a complex 3-dimensional vascular structure...
January 19, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29360524/dual-anticoagulant-plus-single-antiplatelet-vs-triple-anticoagulant-plus-dual-antiplatelet-antithrombotic-therapy-real-world-experience
#15
REVIEW
Mark B Effron, C Michael Gibson
Atrial fibrillation (AF) is a common arrhythmia that increases in prevalence with advancing age and in patients with coronary artery disease, revascularization, particularly with percutaneous coronary intervention (PCI), is also common. Both disease states have thrombosis as a core pathophysiologic process which requires treatment - low sheer stress thrombi in AF and intracoronary high sheer stress thrombi in PCI. For the 10-20% of patients who have both AF and undergo PCI, preventing thrombotic complications will require inhibition of both processes requiring simultaneous use of anticoagulation and antiplatelet therapy...
January 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29357752/prevention-of-minor-myocardial-injury-after-elective-percutaneous-coronary-intervention-comparison-of-ticagrelor-versus-clopidogrel
#16
Hüseyin Göksülük, Yusuf Atmaca, Menekşe Gerede Uludağ, Cansın Tulunay Kaya, Onur Yıldırım, Müge Akbulut, Nil Özyüncü, Cetin Erol
BACKGROUND: Elective percutaneous coronary intervention (ePCI) may cause minor elevation of cardiac enzymes, so-called minor myocardial injury (MMI) which can be due to different pathophysiological mechanism (e.g. distal embolisation, side branch occlusion, increased platelet activation triggered by the intracoronary metallic stents). We aimed to compare the effectiveness of ticagrelor versus clopidogrel for the prevention of MMI and major adverse clinical events (MACEs) after ePCI. METHODS: Study population consisted of two groups of patients based on the treatment: Group I, receiving clopidogrel (n = 104), Group II, receiving ticagrelor (n = 96)...
January 22, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29356018/the-evolving-view-of-coronary-artery-calcium-and-cardiovascular-disease-risk
#17
REVIEW
Isac C Thomas, Nketi I Forbang, Michael H Criqui
Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. The most commonly used measure of CAC, the Agatston unit, effectively models both higher density and higher area of CAC as risk factors for future CVD events...
January 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#18
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29339714/stent-thrombosis-in-patients-with-drug-eluting-stents-and-bioresorbable-vascular-scaffolds-the-feared-complication
#19
Laura S Kerkmeijer, Erhan Tenekecioglu, Joanna J Wykrzykowska
The percutaneous coronary intervention has undergone rapid evolution over the last 40 years and has become one of the most widely performed medical procedures. The introduction of intracoronary stents improved the safety and efficacy of percutaneous coronary intervention. But with the advent of stenting, a new potentially fatal enemy emerged: stent thrombosis. Ever since, adjunct pharmacological therapy, stent technique and technology have been adjusted to reduce the risk of stent thrombosis. The aim of the present article is to provide an overview of past, present and future aspects of percutaneous intervention in relation to stent thrombosis...
January 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29334505/the-association-of-chronic-air-pollutants-with-coronary-artery-spasm-vasospastic-angina-and-endothelial-dysfunction
#20
Byoung Geol Choi, Jiwon Lee, Suhng Wook Kim, Min Woo Lee, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND: We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. PATIENTS AND METHODS: A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www...
January 12, 2018: Coronary Artery Disease
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