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Intracoronary

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https://www.readbyqxmd.com/read/29655768/cell-free-dna-and-microvascular-damage-in-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#1
Juan Sanchis, Sergio García-Blas, Luis Ortega-Paz, Ana Paula Dantas, Enrique Rodríguez, Lidia Abellán, Salvatore Brugaletta, Ernesto Valero, Gema Miñana, Manuel Garabito, África Corchón, Julio Núñez, Arturo Carratalá, Manel Sabaté
INTRODUCTION AND OBJECTIVES: Cell-free DNA (cfDNA) in ST-segment elevation myocardial infarction might originate from hyperactivated leukocytes at the coronary lesion. Our aim was to investigate the relationship between cfDNA and coronary reperfusion. METHODS: We studied 116 patients treated with primary angioplasty using thrombus aspiration. Coronary (during aspiration) and peripheral (at the end of the procedure) blood samples were drawn for cfDNA, as well as high-sensitivity troponin T and myeloperoxidase quantification...
April 11, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29628643/protocols-for-sodium-ascorbate-application-on-intracoronary-dentin-bleached-with-high-concentrated-agent
#2
Thiago Vinicius Cortez, Isabella Rodrigues Ziotti, Renata Siqueira Scatolin, Silmara Aparecida Milori Corona, Aline Evangelista Souza-Gabriel
Purpose: Composite resin restorations are normally replaced after the internal bleaching of endodontically treated-teeth because the bleaching agent does not alter the color of the restorative material. This study evaluated the effect of 10% sodium ascorbate (SA) applied at different protocols on bleached dentin. Materials and Methods: One-hundred slabs of intracoronary bovine dentin were divided into 5 groups: 2 controls-GI without bleaching (positive), GII bleached with 35% hydrogen peroxide (HP) (negative); and 3 experimentals - GIII...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29624174/shining-light-on-calcified-lesions-plaque-stabilisation-and-physiologic-significance-new-insights-from-intracoronary-oct
#3
Ziad A Ali, Keyvan Karimi Galougahi
No abstract text is available yet for this article.
April 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29618307/safety-and-efficacy-of-adenovirus-carrying-hepatocyte-growth-factor-gene-by-percutaneous-endocardial-injection-for-treating-post-infarct-heart-failure-a-phase-iia-clinical-trial
#4
Haoyu Meng, Bo Chen, Zhengxian Tao, Zhihui Xu, Liansheng Wang, Ju Weizhu, Yongyong Hong, Xiang Liu, Hua Wang, Lisheng Wang, Zuze Wu, Zhijian Yan
OBJECTIVE: Our previous phase I clinical trial has confirmed the safety of adenovirus carrying hepatocyte growth factor gene (Ad-HGF) by intracoronary administration for treating severe coronary artery disease. This study was performed to evaluated the safety and efficacy of Ad-HGF by percutaneous endocardial injection for treating post-infarct heart failure. METHODS: A total of 30 patients (15 in the experimental group and 15 in the control group) with post-infarct heart failure who were not indicated to revascularization and had received the optimal standardized medication therapy were included in the study...
April 4, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29605246/influence-of-local-myocardial-damage-on-index-of-microcirculatory-resistance-and-fractional-flow-reserve-in-target-and-nontarget-vascular-territories-in-a-porcine-microvascular-injury-model
#5
Joo Myung Lee, Hyun Kuk Kim, Kyung Seob Lim, Jun-Kyu Park, Ki Hong Choi, Jonghanne Park, Doyeon Hwang, Tae-Min Rhee, Jeong Hoon Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Joo-Yong Hahn, Bon-Kwon Koo, Myung Ho Jeong
OBJECTIVES: The aim of this study was to investigate the influence of microvascular damage in one vessel territory on invasively measured physiological parameters in the other vessel, using a porcine microvascular damage model. BACKGROUND: Although fractional flow reserve (FFR)-guided decision-making for the nonculprit stenosis in patients with acute myocardial infarction has been reported to be better than angiography-guided revascularization, there have been debates regarding the influence of microvascular dysfunction on measured FFR in nonculprit vessels...
March 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29598865/pet-assessment-of-epicardial-intimal-disease-and-microvascular-dysfunction-in-cardiac-allograft-vasculopathy
#6
Sharon Chih, Aun Yeong Chong, Fernanda Erthal, Robert A deKemp, Ross A Davies, Ellamae Stadnick, Derek Y So, Christopher Overgaard, George Wells, Lisa M Mielniczuk, Rob S B Beanlands
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure and death after heart transplantation. Absolute myocardial blood flow (MBF) quantification using rubidium 82 (Rb-82) positron emission tomography (PET) could enable evaluation of diagnostically challenging diffuse epicardial and microvascular disease in CAV. OBJECTIVES: The authors aimed to evaluate Rb-82 PET detection of CAV. METHODS: Consecutive transplant recipients undergoing coronary angiography were prospectively evaluated with PET, multivessel intravascular ultrasound (IVUS), and intracoronary hemodynamics...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29588734/expert-opinion-optimising-stent-deployment-in-contemporary-practice-the-role-of-intracoronary-imaging-and-non-compliant-balloons
#7
Ashok Seth, Sajal Gupta, Vivudh Pratap Singh, Vijay Kumar
Final stent dimensions remain an important predictor of restenosis, target vessel revascularisation (TVR) and subacute stent thrombosis (ST), even in the drug-eluting stent (DES) era. Stent balloons are usually semi-compliant and thus even high-pressure inflation may not achieve uniform or optimal stent expansion. Post-dilatation with non-compliant (NC) balloons after stent deployment has been shown to enhance stent expansion and could reduce TVR and ST. Based on supporting evidence and in the absence of large prospective randomised outcome-based trials, post-dilatation with an NC balloon to achieve optimal stent expansion and maximal luminal area is a logical technical recommendation, particularly in complex lesion subsets...
September 2017: Interventional Cardiology
https://www.readbyqxmd.com/read/29577420/infarction-of-the-septomarginal-band-and-tricuspid-papillary-muscle-rupture-related-to-alcohol-septal-ablation-for-hypertrophic-cardiomyopathy
#8
Munevver Sari, Cemil Izgi, Gokhan Kahveci, Alev Kilicgedik, Zubeyde Bayram, Suzan Hatipoglu, Selcuk Pala, Nihal Ozdemir
We presented a 77-year-old man with hypertrophic obstructive cardiomyopathy applied with flail tricuspid leaflet and severe tricuspid regurgitation leading to right heart failure 2 months after the failed septal ablation. The ruptured anterior tricuspid papillary muscle resulted from infarction of the base of anterior papillary muscle of the right ventricle (RV) confirmed by magnetic resonance imaging. As the septomarginal band is frequently lit up by intracoronary contrast that particular attention should be paid to the RV papillary muscles...
March 25, 2018: Echocardiography
https://www.readbyqxmd.com/read/29569254/stem-cell-therapy-in-st-segment-elevation-myocardial-infarction-with-reduced-ejection-fraction-a-multicenter-double-blind-randomized-trial
#9
José C Nicolau, Remo H M Furtado, Suzana A Silva, Carlos E Rochitte, Anis Rassi, João B M C Moraes, Edgard Quintella, Costantino R Costantini, Adrian P M Korman, Marco A Mattos, Hélio J Castello, Adriano Caixeta, Hans F R Dohmann, Antonio C C de Carvalho
BACKGROUND: Left ventricular ejection fraction (LVEF) is a major determinant of long-term prognosis after ST-segment elevation myocardial infarction (STEMI). STEMI patients with reduced LVEF have a poor prognosis, despite successful reperfusion and the use of renin-angiotensin-aldosterone inhibitors. HYPOTHESIS: Intracoronary infusion of bone marrow-derived mononuclear cells (BMMC) may improve LVEF in STEMI patients successfully reperfused. METHODS: The main inclusion criteria for this double-blind, randomized, multicenter study were patient age 30 to 80 years, LVEF ≤50%, successful angioplasty of infarct-related artery, and regional dysfunction in the infarct-related area analyzed before cell injection...
March 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29564344/cardiovascular-outcomes-following-kawasaki-disease-in-moscow-russia-a-single-center-experience
#10
Galina Lyskina, Olga Bockeria, Olga Shirinsky, Alena Torbyak, Anna Leontieva, Nina Gagarina, Anna Satyukova, Julia Kostina, Olga Vinogradova
Background: Awareness of Kawasaki disease (KD) is emerging in Russia but the diagnosis is still often missed. Methods: This is a retrospective study of 303 children with KD who received care at a single center in Moscow over the period from 2004 to 2016. Results: Overall, coronary artery aneurysms were documented in 91 (30,0%) of 303 patients and transient ectasia in 40 (13,2%). Intracoronary thrombi were found in 12 of 15 patients with giant aneurysms and in 3 patients with medium-sized aneurysms. Conclusion: The patients with KD in the Moscow region had typical features of the disease described in the literature but the proportion of patients with coronary artery aneurysms was higher than reported from other countries...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29560624/polymeric-endovascular-strut-and-lumen-detection-algorithm-for-intracoronary-optical-coherence-tomography-images
#11
Junedh M Amrute, Lambros S Athanasiou, Farhad Rikhtegar, José M de la Torre Hernández, Tamara García Camarero, Elazer R Edelman
Polymeric endovascular implants are the next step in minimally invasive vascular interventions. As an alternative to traditional metallic drug-eluting stents, these often-erodible scaffolds present opportunities and challenges for patients and clinicians. Theoretically, as they resorb and are absorbed over time, they obviate the long-term complications of permanent implants, but in the short-term visualization and therefore positioning is problematic. Polymeric scaffolds can only be fully imaged using optical coherence tomography (OCT) imaging-they are relatively invisible via angiography-and segmentation of polymeric struts in OCT images is performed manually, a laborious and intractable procedure for large datasets...
March 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29553991/intracoronary-versus-intravenous-adenosine-to-assess-fractional-flow-reserve-a-systematic-review-and-meta-analysis
#12
Sebastiano Gili, Umberto Barbero, Daniele Errigo, Giuseppe De Luca, Giuseppe Biondi-Zoccai, Antonio Maria Leone, Mario Iannaccone, Antonio Montefusco, Pierluigi Omedé, Claudio Moretti, Maurizio D'Amico, Fiorenzo Gaita, Fabrizio D'Ascenzo
AIMS: Intravenous infusion of adenosine is the reference method to measure fractional flow reserve (FFR). Intracoronary boluses are often used because of time and convenience, but their effectiveness has yet to be assessed. METHODS: We conducted a systematic review and meta-analysis of prospective studies directly comparing intravenous and intracoronary adenosine administration for FFR measurement. FFR values and prevalence of functionally critical lesions obtained with the different methods of adenosine administration were compared...
March 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29552237/coronary-arterial-spasm-detected-by-coronary-computed-tomography-angiography-and-confirmed-by-intravascular-ultrasound
#13
Masafumi Nakayama, Masaharu Hirano, Sonoka Goto, Akifumi Watanabe, Takashi Uchiyama
A 40-year-old man was admitted to our hospital for chest pain after smoking. Coronary computed tomography angiography showed severe stenosis in the left anterior descending artery. The stenosis site had no plaque on stretched curved multiplanar reconstruction and short-axis images. Coronary angiography revealed improvement of the severe stenosis after the intracoronary administration of isosorbide dinitrate in the left anterior descending artery. Intravascular ultrasound demonstrated negative remodeling without a plaque and diffuse intima with media thickening at the stenosis site...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29549452/spontaneous-coronary-artery-dissection-diagnosis-and-management
#14
REVIEW
Ilhwan Yeo, Dmitriy N Feldman, Luke K Kim
PURPOSE OF REVIEW: Spontaneous coronary artery dissection (SCAD) is a non-iatrogenic and non-traumatic separation of the coronary arterial wall. While SCAD represents an important cause of myocardial infarction, optimal diagnostic and therapeutic options remain challenging. We sought to review recent studies and provide an update on diagnosis and management of SCAD. RECENT FINDINGS: Coronary angiography is the first-line diagnostic modality for SCAD, with three angiographic features commonly observed in SCAD: type 1 (pathognomonic angiographic appearance with contrast staining of the arterial wall), type 2 (long coronary stenosis), and type 3 (focal tubular stenosis)...
March 17, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29549347/non-invasive-coronary-physiology-based-on-computational-analysis-of-intracoronary-transluminal-attenuation-gradient
#15
Yong Gyun Bae, Seung Tae Hwang, Huan Han, Sung Mok Kim, Hyung-Yoon Kim, Il Park, Joo Myung Lee, Young-June Moon, Jin-Ho Choi
Invasive procedure is a prerequisite for studying coronary physiology. We established the measurement of non-invasive physiological parameters including coronary blood flow (CBF), flow velocity, and microvascular resistance using coronary computed tomography angiography (CCTA). Vessel-specific CBF was derived from transluminal attenuation flow encoding (TAFE) and then tested using three separate datasets consisted of computational simulation, human perfusion CT, and human CCTA. TAFE-derived CBF correlated well with measured vessel-specific myocardial blood flow and CBF...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540631/current-use-of-intracoronary-imaging-in-interventional-practice-results-of-a-european-association-of-percutaneous-cardiovascular-interventions-eapci-and-japanese-association-of-cardiovascular-interventions-and-therapeutics-cvit-clinical-practice-survey
#16
Konstantinos C Koskinas, Masato Nakamura, Lorenz Räber, Roisin Colleran, Kazushige Kadota, Davide Capodanno, William Wijns, Takashi Akasaka, Marco Valgimigli, Giulio Guagliumi, Stephan Windecker, Robert A Byrne
BACKGROUND: This study evaluated the views of the cardiology community on the clinical use of coronary intravascular imaging (IVI).Methods and Results:A web-based survey was distributed to 31,893 individuals, with 1,105 responses received (3.5% response rate); 1,010 of 1,097 respondents (92.1%) self-reported as interventional cardiologists, 754 (68.7%) with >10 years experience. Overall, 96.1% had personal experience with IVI (95.5% with intravascular ultrasound [IVUS], 69.8% with optical coherence tomography [OCT], and 7...
March 15, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29538502/association-of-monocyte-count-on-admission-with-the-angiographic-thrombus-burden-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#17
Zuoyan Wang, Na Liu, Lihui Ren, Licheng Lei, Huiming Ye, Jianjun Peng
BACKGROUND: The intracoronary high-thrombus burden during the primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction (STEMI) can lead to poor outcomes. Monocytes have been described to play an important role in thrombotic disorders. OBJECTIVES: This study aimed to investigate the relationship between admission monocyte count and angiographic intracoronary thrombus burden in patients receiving primary percutaneous coronary intervention (PPCI)...
March 12, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29537966/current-use-of-intracoronary-imaging-in-interventional-practice-results-of-a-european-association-of-percutaneous-cardiovascular-interventions-eapci-and-japanese-association-of-cardiovascular-interventions-and-therapeutics-cvit-clinical-practice-survey
#18
Konstantinos C Koskinas, Masato Nakamura, Lorenz Räber, Roisin Colleran, Kazushige Kadota, Davide Capodanno, William Wijns, Takashi Akasaka, Marco Valgimigli, Giulio Guagliumi, Stephan Windecker, Robert A Byrne
AIMS: This study evaluated the views of the cardiology community on the clinical use of coronary intravascular imaging (IVI). METHODS AND RESULTS: A web-based survey was distributed to 31,893 individuals, with 1,105 responses received (3.5% response rate); 1,010 of 1,097 respondents (92.1%) self-reported as interventional cardiologists, 754 (68.7%) with >10 years experience. Overall, 96.1% had personal experience with IVI (95.5% with intravascular ultrasound [IVUS], 69...
March 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29532358/submucosal-hematoma-of-the-sigmoid-colon-as-a-complication-of-anticoagulation-treatment
#19
Huijiang Zhou, Shuai Wang, Lin Zhu
BACKGROUND: Anticoagulation therapy after coronary stent implantation is necessary and crucial for patients with severe coronary heart disease. Submucosal bleeding of the colon is an infrequent complication of anticoagulants. METHODS: TWe present the case of a 70-year-old woman with spontaneous submucosal hematoma and active bleeding of her sigmoid colon due to anticoagulants after intracoronary stenting. RESULTS: This patient underwent a timely surgical operation...
March 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29526680/endothelial-dysfunction-of-coronary-arteries-in-subjects-without-diabetes-an-association-with-both-insulin-resistance-and-impaired-insulin-secretion-response
#20
Katarina Lalić, Milan Nedeljković, Alekasandra Jotić, Rade Babić, Nataša Rajković, Ljiljana Popović, Ljiljana Lukić, Tanja Miličić, Sandra Singh Lukač, Ljubica Stošić, Marija Maćešić, Iva Rasulić, Jelena Stanarčić Gajović, Nebojša M Lalić
AIMS: This study was aimed to compare insulin sensitivity and secretion response, lipoprotein and plasminogen activator inhibitor 1 (PAI-1) levels between the subjects with and without coronary artery endothelial dysfunction (ED). METHODS: ED was detected by intracoronary injection of acetylcholine (ACh) in 47 nondiabetes subjects without stenotic coronary arteries, selected from 316 consecutive patients with coronary angiography performed for suspected coronary artery disease...
March 8, 2018: Diabetes Research and Clinical Practice
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