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Leptin and cardiovascular disease

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https://www.readbyqxmd.com/read/28440766/unfavorable-cytokine-and-adhesion-molecule-profiles-during-and-after-pregnancy-in-women-with-gestational-diabetes-mellitus
#1
María Del Mar Roca-Rodríguez, Cristina López-Tinoco, Álvaro Fernández-Deudero, Mora Murri, María Victoria García-Palacios, María Del Amor García-Valero, Francisco José Tinahones, Manuel Aguilar-Diosdado
BACKGROUND: Gestational diabetes mellitus is a significant risk factor for metabolic syndrome and cardiovascular disease. AIMS: To assess the relationships between components of the metabolic syndrome and cytokine and adhesion molecule levels in women with GDM during pregnancy and after delivery. PATIENTS AND METHODS: A prospective case-control study on a sample of 126 pregnant women (63 with and 63 without gestational diabetes mellitus). In an intra-subject analysis, 41 women with history of gestational diabetes mellitus and 21 controls were re-assessed in the postpartum period...
January 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28437199/the-correlation-of-arterial-stiffness-with-biophysical-parameters-and-blood-biochemistry
#2
Anamil M Khiyami, Fiona J Dore, Aytan Mammadova, Richard L Amdur, Sabyasachi Sen
INTRODUCTION: Type 2 diabetes presents with numerous macrovascular and microvascular impairments, which in turn lead to various co-morbidities. Vascular co-morbidities can be seen when examining arterial stiffness (AS), which is a predictor for endothelial health and cardiovascular disease risk. Pulse wave analysis (PWA) and pulse wave velocity (PWV) are two tests that are commonly used to measure AS. Currently, disease states and progression are tracked via blood biochemistry. These gold standards in monitoring diabetes are expensive and need optimization...
May 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28433698/adipose-crosstalk-with-other-cell-types-in-health-and-disease
#3
REVIEW
Chan Hee J Choi, Paul Cohen
In addition to storing and mobilizing energy, adipocytes secrete circulating factors to signal to other tissues and coordinate energy metabolism. These functions can become disrupted in the setting of obesity, contributing to the development of diabetes, cardiovascular disease, and cancer. Since the discovery of leptin and adiponectin, an increasing number of adipokines have been identified and their functions elucidated. More recent studies have highlighted other modes by which adipose tissue can participate in crosstalk with other cell types and tissues...
April 19, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28410617/treatment-with-high-dose-n-3-pufas-has-no-effect-on-platelet-function-coagulation-metabolic-status-or-inflammation-in-patients-with-atherosclerosis-and-type-2-diabetes
#4
Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas, Grzegorz Gajos
BACKGROUND: Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascular risk in patients with type 2 diabetes (DM2) and established atherosclerosis. PURPOSE: To investigate the effect of daily treatment with a higher dose (2 g) of n-3 PUFAs on platelet function, coagulation parameters, fibrin clot properties, markers of systemic inflammation and metabolic status, in patients with atherosclerotic vascular disease and DM2 who receive optimal medical therapy...
April 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28409494/association-between-metabolically-healthy-central-obesity-in-women-and-levels-of-soluble-receptor-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-and-the-activity-of-semicarbazide-sensitive-amine-oxidase
#5
Ivana Koborová, Radana Gurecká, Melinda Csongová, Katarína Volkovová, Éva Szökő, Tamás Tábi, Katarína Šebeková
AIM: To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). METHODS: 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28382609/metabolic-syndrome-as-a-factor-affecting-systemic-inflammation-in-patients-with-chronic-obstructive-pulmonary-disease
#6
R Rubinsztajn, T Przybyłowski, M Maskey-Warzęchowska, M Paplińska-Goryca, P Nejman-Gryz, K Karwat, R Chazan
Chronic obstructive pulmonary disease (COPD) is a systemic disease which may be associated with other comorbidities. The aim of the study was to estimate the incidence of metabolic syndrome (MS) in COPD patients and to assess its impact on systemic inflammation and lung function. MS was diagnosed in accordance with the recommendations of the Polish Forum for the Prevention of Cardiovascular Diseases. The study group consisted of 267 patients with stable COPD in all stages of severity. All patients underwent spirometry with bronchial reversibility testing and 6 min walk test (6MWT)...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28368354/leptin-receptor-gene-polymorphism-and-the-risk-of-cardiovascular-disease-a-systemic-review-and-meta-analysis
#7
REVIEW
Lei Wu, Dali Sun
OBJECTIVE: Few studies have assessed the association between leptin receptor (LEPR) gene polymorphism and the risk of cardiovascular disease (CVD). Of the few epidemiological studies on this topic, the results are still controversial. METHODS: PubMed and Embase were screened for studies from their inception to 9 October 2016. The pooled odds ratio (OR) with the corresponding confidence intervals (CI) were used to measure the effect size for studies that reported the association under allelic, homozygous, and dominant models...
April 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28362475/the-genetic-basis-of-obesity-complications
#8
Katarzyna Skrypnik, Joanna Suliburska, Damian Skrypnik, Łukasz Pilarski, Julita Reguła, Paweł Bogdański
Intensive research is currently being performed into the genetic background of excess body mass compli- cations such as diabetes, cardiovascular disorders, especially atherosclerosis and coronary heart disease. Chronic inflammation is an important process in the pathogenesis of obesity, wherein there is an aberrant ex- pression of genes encoding adipokines. Visceral tissue is characterized by a higher expression and secretion of interleukin-8, interleukin-1ß and plasminogen activator inhibitor 1 in the subcutaneous tissue secretion of leptin prevails...
January 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28333114/inflammatory-cytokines-as-uremic-toxins-ni-son-todos-los-que-estan-ni-estan-todos-los-que-son
#9
REVIEW
Esmeralda Castillo-Rodríguez, Soledad Pizarro-Sánchez, Ana B Sanz, Adrian M Ramos, Maria Dolores Sanchez-Niño, Catalina Martin-Cleary, Beatriz Fernandez-Fernandez, Alberto Ortiz
Chronic kidney disease is among the fastest growing causes of death worldwide. An increased risk of all-cause and cardiovascular death is thought to depend on the accumulation of uremic toxins when glomerular filtration rate falls. In addition, the circulating levels of several markers of inflammation predict mortality in patients with chronic kidney disease. Indeed, a number of cytokines are listed in databases of uremic toxins and uremic retention solutes. They include inflammatory cytokines (IL-1β, IL-18, IL-6, TNFα), chemokines (IL-8), and adipokines (adiponectin, leptin and resistin), as well as anti-inflammatory cytokines (IL-10)...
March 23, 2017: Toxins
https://www.readbyqxmd.com/read/28318332/abnormality-of-adipokines-and-endothelial-dysfunction-in-mexican-obese-adolescents-with-insulin-resistance
#10
Maria Del Carmen Ortiz Segura, Blanca Estela Del Río Navarro, Benjamín Antonio Rodríguez Espino, Laurence A Marchat, Fausto Sánchez Muñoz, Santiago Villafaña, Enrique Hong, Fabián Meza-Cuenca, Patrick Mailloux Salinas, Francisco Bolaños-Jiménez, Elena Zambrano, Abel Armando Arredondo-López, Guadalupe Bravo, Fengyang Huang
PURPOSE: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). MATERIALS AND METHODS: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65)...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28301988/the-influence-of-lipid-and-proinflammatory-status-on-maternal-uterine-blood-flow-in-women-with-late-onset-gestational-diabetes
#11
Fernando Bugatto, Rocío Quintero-Prado, Francisco M Visiedo, José M Vilar-Sánchez, Alejandro Figueroa-Quiñones, Cristina López-Tinoco, Rafael Torrejón, José L Bartha
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased proinflammatory cytokines and is also associated with adverse cardiovascular disease (CVD) outcomes later in life. We aim to evaluate the relationships between uterine arteries vascularization and endothelial dysfunction markers, proinflammatory cytokines, and glycemic and lipid profile in women with GDM. METHODS: Fifty pregnant women were recruited at the third trimester of pregnancy for a prospective cohort study...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28300429/leptin-predicts-short-term-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#12
Veli-Pekka Puurunen, Antti Kiviniemi, Samuli Lepojärvi, Olli-Pekka Piira, Pirjo Hedberg, Juhani Junttila, Olavi Ukkola, Heikki Huikuri
INTRODUCTION: Leptin is an adipose tissue-derived hormone associated with cardiovascular risk factors. We examined whether leptin predicts major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. METHODS: Fasting plasma leptin levels were measured in 1327 male and 619 female CAD patients. The patients were followed up for two years. The primary endpoint (MACE) was the composite of a hospitalisation for congestive heart failure (CHF) or a cardiac death...
March 16, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28298072/the-anti-osteoporotic-and-anti-atherogenic-effects-of-alendronate-and-simvastatin-in-ovariectomized-rats-fed-high-fat-diet-a-comparative-study-of-combination-therapy-versus-monotherapy
#13
Maha Tarek Mohamed, Sally A Abuelezz, Suzi Sobhy Atalla, Lobna Fouad Abd El Aziz, Sonia Salib Gorge
AIM: Epidemiological studies suggest a possible link between osteoporosis and cardiovascular diseases. Mevalonate pathway was pointed to as a part of this link. This study was done to investigate the effects of Alendronate (Al) and Simvastatin (Sim), both act on the mevalonate pathway, on osteoporosis, dyslipidemia and atherosclerotic changes in ovariectomized (OVX) rats fed high fat diet (HFD). MAIN METHODS: 60 female albino rats were equally divided into 5 groups: control sham, OVX-HFD untreated, OVX -HFD treated with Al (3mg/kg/d) or/and Sim (6mg/kg/d)...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28285098/role-of-leptin-as-a-link-between-metabolism-and-the-immune-system
#14
REVIEW
Antonio Pérez-Pérez, Teresa Vilariño-García, Patricia Fernández-Riejos, Jenifer Martín-González, Juan José Segura-Egea, Víctor Sánchez-Margalet
Leptin is an adipocyte-derived hormone not only with an important role in the central control of energy metabolism, but also with many pleiotropic effects in different physiological systems. One of these peripheral functions of leptin is a regulatory role in the interplay between energy metabolism and the immune system, being a cornerstone of the new field of immunometabolism. Leptin receptor is expressed throughout the immune system and the regulatory effects of leptin include cells from both the innate and adaptive immune system...
March 4, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28279502/circulating-microparticle-subpopulations-in-systemic-lupus-erythematosus-are-affected-by-disease-activity
#15
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Luis Caminal-Montero, Ana Suárez
BACKGROUND: Immune cells under chronic inflammation shed microparticles (MPs) that could fuel the inflammatory responses and atherosclerosis typically presented in systemic lupus erythematosus (SLE). This study analyzes total and subset-specific MPs from SLE patients and their possible influence on clinical features, leukocyte activation and serum cytokines. METHODS: Total MPs and those derived from platelets, endothelial cells, monocytes, granulocytes and T-cells were quantified in plasma of 106 SLE patients and 33 healthy controls by flow cytometry...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28279422/cardio-oncology-related-to-heart-failure-common-risk-factors-between-cancer-and-cardiovascular-disease
#16
REVIEW
Anne Blaes, Anna Prizment, Ryan J Koene, Suma Konety
There is a growing body of evidence that suggests cancer and cardiovascular disease have a shared biological mechanism. Although there are several shared risk factors for both diseases, including advancing age, gender, obesity, diabetes, physical activity, tobacco use, and diet, inflammation and biomarkers, such as insulinlike growth factor 1, leptin, estrogen, and adiponectin, may also play a role in the biology of these diseases. This article provides an overview of the shared biological mechanism between cancer and cardiovascular disease...
April 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28279166/effects-of-cold-sensitivity-in-the-extremities-on-circulating-adiponectin-levels-and-metabolic-syndrome-in-women
#17
Ah Yeon Park, Seongwon Cha
BACKGROUND: In adipose tissues, adipokine levels, including adiponectin and leptin, are involved in insulin sensitivity and are reciprocally induced by cold temperature stress. Thermogenic response in the extremities (hands and feet) against cold stress can be negatively related to fat mass accumulation, particularly in the abdomen. However, the relationship between the sensation of cold in the extremities and circulating levels of adipokines is not fully understood. Here, we investigated whether adipokine levels are associated with cold hypersensitivity in the hands and feet (CHHF), independent of body mass, and whether the CHHF is related to metabolic syndrome (MS)...
March 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28278178/leptin-concentration-and-risk-of-coronary-heart-disease-and-stroke-a-systematic-review-and-meta-analysis
#18
Han Yang, Wenzhi Guo, Jie Li, Shengli Cao, Jiakai Zhang, Jie Pan, Zhihui Wang, Peihao Wen, Xiaoyi Shi, Shuijun Zhang
BACKGROUND AND PURPOSE: Although high leptin concentration has been shown to be correlated with established vascular risk factors, epidemiologic studies have reported inconclusive results on the association between leptin and cardiovascular diseases (CVD). Therefore, a meta-analysis was performed to evaluate this issue. METHODS: We searched Pubmed, Embase, and the Cochrane Library from their inception to Jan 2016 for both case-control and cohort studies that assessed leptin concentration and CVD risk...
2017: PloS One
https://www.readbyqxmd.com/read/28243353/aspalatone-prevents-vegf-induced-lipid-peroxidation-migration-tube-formation-and-dysfunction-of-human-aortic-endothelial-cells
#19
Himangshu Sonowal, Pabitra B Pal, Kirtikar Shukla, Kota V Ramana
Although aspalatone (acetylsalicylic acid maltol ester) is recognized as an antithrombotic agent with antioxidative and antiplatelet potential; its efficacy in preventing endothelial dysfunction is not known. In this study, we examined the antiangiogenic, antioxidative, and anti-inflammatory effect of aspalatone in human aortic endothelial cells (HAECs). Specifically, the effect of aspalatone on VEGF-induced HAECs growth, migration, tube formation, and levels of lipid peroxidation-derived malondialdehyde (MDA) was examined...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28237179/translating-the-biology-of-adipokines-in-atherosclerosis-and-cardiovascular-diseases-gaps-and-open-questions
#20
REVIEW
M Ruscica, A Baragetti, A L Catapano, G D Norata
AIM: Critically discuss the available data, to identify the current gaps and to provide key concepts that will help clinicians in translating the biology of adipokines in the context of atherosclerosis and cardio-metabolic diseases. DATA SYNTHESIS: Adipose tissue is nowadays recognized as an active endocrine organ, a function related to the ability to secrete adipokines (such as leptin and adiponectin) and pro-inflammatory cytokines (tumor necrosis factor alpha and resistin)...
December 23, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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