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Multi-electrode array

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https://www.readbyqxmd.com/read/29464573/intrinsic-inflammation-is-a-potential-anti-epileptogenic-target-in-the-organotypic-hippocampal-slice-model
#1
Seon-Ah Chong, Silvia Balosso, Catherine Vandenplas, Gregory Szczesny, Etienne Hanon, Kasper Claes, Xavier Van Damme, Bénédicte Danis, Jonathan Van Eyll, Christian Wolff, Annamaria Vezzani, Rafal M Kaminski, Isabelle Niespodziany
Understanding the mechanisms of epileptogenesis is essential to develop novel drugs that could prevent or modify the disease. Neuroinflammation has been proposed as a promising target for therapeutic interventions to inhibit the epileptogenic process that evolves from traumatic brain injury. However, it remains unclear whether cytokine-related pathways, particularly TNFα signaling, have a critical role in the development of epilepsy. In this study, we investigated the role of innate inflammation in an in vitro model of post-traumatic epileptogenesis...
February 20, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29454965/detection-of-synchronized-burst-firing-in-cultured-human-induced-pluripotent-stem-cell-derived-neurons-using-a-4-step-method
#2
N Matsuda, A Odawara, H Kato, N Okuyama, R Yokoi, I Suzuki
Human induced pluripotent stem cell-derived neurons are promising for use in toxicity evaluations in nonclinical studies. The multi-electrode array (MEA) assay is used in such evaluation systems because it can measure the electrophysiological function of a neural network noninvasively and with high throughput. Synchronized burst firing (SBF) is the main analytic parameter of pharmacological effects in MEA data, but an accurate method for detecting SBFs has not been established. In this study, we present a 4-step method that accurately detects a target SBF confirmed by the researcher's interpretation of a raster plot...
February 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29438866/a-comparison-of-graphene-hydrogels-modified-with-single-walled-multi-walled-carbon-nanotubes-as-electrode-materials-for-capacitive-deionization
#3
Jianglin Cao, Ying Wang, Chunyang Chen, Fei Yu, Jie Ma
Capacitive deionization (CDI) is a technology used to remove salt from brackish water, and it is an energy-saving, low-cost method compared with other methods, such as reverse osmosis, multi-stage ash distillation and electrodialysis. In this paper, three-dimensional (3D) graphene hydrogels modified with single-walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs) were synthesized by a one-step water bath method to increase the conductivity of materials and reduce the aggregation of the graphene sheets...
February 7, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29426924/a-biopotential-optrode-array-operation-principles-and-simulations
#4
Amr Al Abed, Hrishikesh Srinivas, Josiah Firth, François Ladouceur, Nigel H Lovell, Leonardo Silvestri
We propose an optical electrode 'optrode' sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode's light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425223/mea-viewer-a-high-performance-interactive-application-for-visualizing-electrophysiological-data
#5
Daniel C Bridges, Kenneth R Tovar, Bian Wu, Paul K Hansma, Kenneth S Kosik
Action potentials can be recorded extracellularly from hundreds of neurons simultaneously with multi-electrode arrays. These can typically have as many as 120 or more electrodes. The brief duration of action potentials requires a high sampling frequency to reliably capture each waveform. The resulting raw data files are therefore large and difficult to visualize with traditional plotting tools. Common approaches to deal with the difficulties of data display, such as extracting spike times and performing spike train analysis, are useful in many contexts but they also significantly reduce data dimensionality...
2018: PloS One
https://www.readbyqxmd.com/read/29421549/unique-electrophysiological-and-impedance-signatures-between-encapsulation-types-an-analysis-of-biological-utah-array-failure-and-benefit-of-a-biomimetic-coating-in-a-rat-model
#6
Patrick A Cody, James R Eles, Carl F Lagenaur, Takashi D Y Kozai, X Tracy Cui
Intracortical microelectrode arrays, especially the Utah array, remain the most common choice for obtaining high dimensional recordings of spiking neural activity for brain computer interface and basic neuroscience research. Despite the widespread use and established design, mechanical, material and biological challenges persist that contribute to a steady decline in recording performance (as evidenced by both diminished signal amplitude and recorded cell population over time) or outright array failure. Device implantation injury causes acute cell death and activation of inflammatory microglia and astrocytes that leads to a chronic neurodegeneration and inflammatory glial aggregation around the electrode shanks and often times fibrous tissue growth above the pia along the bed of the array within the meninges...
January 31, 2018: Biomaterials
https://www.readbyqxmd.com/read/29421525/impact-of-calcium-sensitive-dyes-on-the-beating-properties-and-pharmacological-responses-of-human-ips-derived-cardiomyocytes-using-the-calcium-transient-assay
#7
Ivan Kopljar, An N Hermans, Ard Teisman, David J Gallacher, Hua Rong Lu
INTRODUCTION: Calcium-based screening of hiPS-CMs is a useful preclinical safety evaluation platform with the ability to generate robust signals that facilitates high-throughput screening and data analysis. However, due to the potential inherent toxicities, it is important to understand potential effects of different calcium-sensitive dyes on the hiPS-CMs model. METHODS: We compared three calcium-sensitive fluorescence dyes (Cal520, ACTOne and Calcium 5) for their impact on the variability, the beating properties and the pharmacological responses of hiPS-CMs using the Hamamatsu FDSS/μCell imaging platform...
February 5, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29419302/all-inkjet-printed-amperometric-multiplexed-biosensors-based-on-nanostructured-conductive-hydrogel-electrodes
#8
Lanlan Li, Lijia Pan, Zhong Ma, Ke Yan, Wen Cheng, Yi Shi, Guihua Yu
Multiplexing, one of the main trends in biosensors, aims to detect several analytes simultaneously by integrating miniature sensors on a chip. However, precisely depositing electrode materials and selective enzymes on distinct microelectrode arrays remains an obstacle to massively produced multiplexed sensors. Here, we report on a "drop-on-demand" inkjet printing process to fabricate multiplexed biosensors based on nanostructured conductive hydrogels, in which the electrode material and several kinds of enzymes were printed on the electrode arrays one by one by employing a multi-nozzle inkjet system...
February 8, 2018: Nano Letters
https://www.readbyqxmd.com/read/29417820/bidirectional-electrochemiluminescence-color-switch-an-application-in-detecting-multi-markers-of-prostate-cancer
#9
Yinzhu Wang, Si-Yuan Ji, Heng-Yu Xu, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
A selective excitation of [Ir(df-ppy)2(pic)] and [Ru(bpy)3]2+ through tuning electrode potential is reported in this work. Bidirectional color change from blue-green to red could be observed along with increase and decrease of the potential, which was ascribed to the dual-potential excitation property of [Ir(df-ppy)2(pic)]. Similar to three-electrode system, selective excitation of ECL could be achieved at the anode of bipolar electrode (BPE). Both increase and decrease of the faradic reactions at the cathode of the BPE could induce ECL reporting color at the other pole switched from blue-green to red...
February 8, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29415927/-development-of-alternatives-to-animal-experiments-using-pluripotent-stem-cells
#10
Koichi Saito, Noriyuki Suzuki, Kumiko Kobayashi
Animal experiments have occupied an important position in the safety assessment of chemicals. However, due to the rise in animal welfare as seen in the ban of animal experiments in European cosmetic development, the development of alternative methods for animal experiments has become very important in recent years. Development of in vitro tests for local toxicity such as irritation and sensitization tests is preceded. Meanwhile, alternative tests for systemic toxicity such as chronic and developmental toxicities are under development...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29414094/a-silicon-based-neural-probe-with-densely-packed-low-impedance-titanium-nitride-microelectrodes-for-ultrahigh-resolution-in-vivo-recordings
#11
Richárd Fiáth, Bogdan Cristian Raducanu, Silke Musa, Alexandru Andrei, Carolina Mora Lopez, Chris van Hoof, Patrick Ruther, Arno Aarts, Domonkos Horváth, István Ulbert
In this study, we developed and validated a single-shank silicon-based neural probe with 128 closely-packed microelectrodes suitable for high-resolution extracellular recordings. The 8-mm-long, 100-µm-wide and 50-µm-thick implantable shank of the probe fabricated using a 0.13-µm complementary metal-oxide-semiconductor (CMOS) metallization technology contains square-shaped (20 × 20 µm2), low-impedance (~ 50 kΩ at 1 kHz) recording sites made of rough and porous titanium nitride which are arranged in a 32 × 4 dense array with an inter-electrode pitch of 22...
January 31, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29409952/adenosine-has-two-faces-regionally-dichotomous-adenosine-tone-in-a-model-of-epilepsy-with-comorbid-sleep-disorders
#12
Ted J Warren, Timothy A Simeone, D David Smith, Ryan Grove, Jiri Adamec, Kaeli K Samson, Harrison M Roundtree, Deepak Madhavan, Kristina A Simeone
OBJECTIVE: Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and hippocampus increase and exert sleep pressure in sleep-deprived and control animals, whereas in epilepsy reduced adenosine tone promotes hyperexcitability. To date, the role of adenosine in pathological conditions that result in both seizures and sleep disorders is unknown. Here, we determined adenosine tone in sleep and seizure regulating brain regions of Kv1...
January 30, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29404551/blue-light-filtered-white-light-induces-depression-like-responses-and-temporary-spatial-learning-deficits-in-rats
#13
Qinghe Meng, Yuzheng Lian, Jianjun Jiang, Wei Wang, Xiaohong Hou, Yao Pan, Hongqian Chu, Lanqin Shang, Xuetao Wei, Weidong Hao
OBJECTIVES: Ambient light has a vital impact on mood and cognitive functions. Blue light has been previously reported to play a salient role in the antidepressant effect via melanopsin. Whether blue light filtered white light (BFW) affects mood and cognitive functions remains unclear. The present study aimed to investigate whether BFW led to depression-like symptoms and cognitive deficits including spatial learning and memory abilities in rats, and whether they were associated with the light-responsive function in retinal explants...
February 6, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29395915/different-levels-of-category-abstraction-by-different-dynamics-in-different-prefrontal-areas
#14
Andreas Wutz, Roman Loonis, Jefferson E Roy, Jacob A Donoghue, Earl K Miller
Categories can be grouped by shared sensory attributes (i.e., cats) or a more abstract rule (i.e., animals). We explored the neural basis of abstraction by recording from multi-electrode arrays in prefrontal cortex (PFC) while monkeys performed a dot-pattern categorization task. Category abstraction was varied by the degree of exemplar distortion from the prototype pattern. Different dynamics in different PFC regions processed different levels of category abstraction. Bottom-up dynamics (stimulus-locked gamma power and spiking) in the ventral PFC processed more low-level abstractions, whereas top-down dynamics (beta power and beta spike-LFP coherence) in the dorsal PFC processed more high-level abstractions...
January 26, 2018: Neuron
https://www.readbyqxmd.com/read/29385243/arrayed-isoelectric-focusing-using-photopatterned-multi-domain-hydrogels
#15
Kevin A Yamauchi, Augusto M Tentori, Amy E Herr
Isoelectric focusing (IEF) is a powerful separation method, useful for resolving subtle changes in the isoelectric point of unlabeled proteins. While microfluidic IEF has reduced the separation times from the hours in traditional benchtop IEF to minutes, the enclosed devices hinder post-separation access to the sample for downstream analysis. The two-layer open IEF device presented here comprises a photopatterned hydrogel lid layer containing the chemistries required for IEF and a thin polyacrylamide bottom layer in which the analytes are separated...
January 31, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29375941/use-of-spinal-cord-stimulation-in-elderly-patients-with-multi-factorial-chronic-lumbar-and-non-radicular-lower-extremity-pain
#16
Michelle Granville, Aldo F Berti, Robert E Jacobson
Spinal cord stimulation (SCS) is an effective treatment for chronic back and limb pain. The criteria for use of SCS for specific problems such as failed back surgery syndrome (FBSS), peripheral neuropathic pain and residual pain after joint replacement is well established. With an aging population, there are more patients presenting with a combination of various multi-factorial chronic pain problems rather than from a single clear cause. It is not uncommon to see patients with chronic back pain years after spine surgery with new additional pain in the area of joint replacement or due to peripheral neuropathy...
November 17, 2017: Curēus
https://www.readbyqxmd.com/read/29367976/hierarchically-structured-multi-shell-nanotube-arrays-by-self-assembly-for-efficient-water-oxidation
#17
Steffen Czioska, Jianying Wang, Xue Teng, Shangshang Zuo, Songhai Xie, Zuofeng Chen
Photosynthesis in plants occurs at structures which form by self-assembly under ambient conditions, while catalysts used for artificial photosynthesis normally need special conditions like high pressure or temperature. Herein, a facile and cost effective way for the synthesis of a highly complex and efficient oxygen evolution reaction (OER) catalyst, formed solely by self-assembly in solution, is presented. Without the need for any instrumentation except for a glass beaker, highly active nickel-iron-copper multi-shell nanotube arrays are produced by immersion of a copper plate in three different solutions...
January 25, 2018: Nanoscale
https://www.readbyqxmd.com/read/29362477/random-neuronal-ensembles-can-inherently-do-context-dependent-coarse-conjunctive-encoding-of-input-stimulus-without-any-specific-training
#18
Jude Baby George, Grace Mathew Abraham, Zubin Rashid, Bharadwaj Amrutur, Sujit Kumar Sikdar
Conjunctive encoding of inputs has been hypothesized to be a key feature in the computational capabilities of the brain. This has been inferred based on behavioral studies and electrophysiological recording from animals. In this report, we show that random neuronal ensembles grown on multi-electrode array perform a coarse-conjunctive encoding for a sequence of inputs with the first input setting the context. Such an encoding scheme creates similar yet unique population codes at the output of the ensemble, for related input sequences, which can then be decoded via a simple perceptron and hence a single STDP neuron layer...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29355722/predicting-cardiac-safety-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-combined-with-multi-electrode-array-mea-technology-a-conference-report
#19
REVIEW
Petra Mulder, Tessa de Korte, Elena Dragicevic, Udo Kraushaar, Richard Printemps, Maria L H Vlaming, Stefan R Braam, Jean-Pierre Valentin
Safety pharmacology studies that evaluate drug candidates for potential cardiovascular liabilities remain a critical component of drug development. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have recently emerged as a new and promising tool for preclinical hazard identification and risk assessment of drugs. Recently, Pluriomics organized its first User Meeting entitled 'Combining Pluricyte® Cardiomyocytes & MEA for Safety Pharmacology applications', consisting of scientific sessions and live demonstrations, which provided the opportunity to discuss the application of hiPSC-CMs (Pluricyte® Cardiomyocytes) in cardiac safety assessment to support early decision making in safety pharmacology...
January 17, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29348493/dna-multi-bit-non-volatile-memory-and-bit-shifting-operations-using-addressable-electrode-arrays-and-electric-field-induced-hybridization
#20
Youngjun Song, Sejung Kim, Michael J Heller, Xiaohua Huang
DNA has been employed to either store digital information or to perform parallel molecular computing. Relatively unexplored is the ability to combine DNA-based memory and logical operations in a single platform. Here, we show a DNA tri-level cell non-volatile memory system capable of parallel random-access writing of memory and bit shifting operations. A microchip with an array of individually addressable electrodes was employed to enable random access of the memory cells using electric fields. Three segments on a DNA template molecule were used to encode three data bits...
January 18, 2018: Nature Communications
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