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Multi-electrode array

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https://www.readbyqxmd.com/read/28642471/multi-layered-nioy-nbox-nioy-fast-drift-free-threshold-switch-with-high-ion-ioff-ratio-for-selector-application
#1
Jaehyuk Park, Tobias Hadamek, Agham B Posadas, Euijun Cha, Alexander A Demkov, Hyunsang Hwang
NbO2 has the potential for a variety of electronic applications due to its electrically induced insulator-to-metal transition (IMT) characteristic. In this study, we find that the IMT behavior of NbO2 follows the field-induced nucleation by investigating the delay time dependency at various voltages and temperatures. Based on the investigation, we reveal that the origin of leakage current in NbOx is partly due to insufficient Schottky barrier height originating from interface defects between the electrodes and NbOx layer...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634147/csahi-study-2-validation-of-multi-electrode-array-systems-mea60-2100-for-prediction-of-drug-induced-proarrhythmia-using-human-ips-cell-derived-cardiomyocytes-assessment-of-reference-compounds-and-comparison-with-non-clinical-studies-and-clinical-information
#2
Yumiko Nozaki, Yayoi Honda, Hitoshi Watanabe, Shota Saiki, Kiyotaka Koyabu, Tetsuji Itoh, Chiho Nagasawa, Chiaki Nakamori, Chiaki Nakayama, Hiroshi Iwasaki, Shinobu Suzuki, Kohji Tanaka, Etsushi Takahashi, Kaori Miyamoto, Kaoru Morimura, Atsuhiro Yamanishi, Hiroko Endo, Junko Shinozaki, Hisashi Nogawa, Tadahiro Shinozawa, Fumiyo Saito, Takeshi Kunimatsu
With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period...
June 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28629926/different-functional-susceptibilities-of-mouse-retinal-ganglion-cell-subtypes-to-optic-nerve-crush-injury
#3
Zhen Puyang, Hai-Qing Gong, Shi-Gang He, John B Troy, Xiaorong Liu, Pei-Ji Liang
In optic neuropathies, the progressive deterioration of retinal ganglion cell (RGC) function leads to irreversible vision loss. Increasing experimental evidence suggests differing susceptibility for RGC functional subtypes. Here with multi-electrode array recordings, RGC functional loss was characterized at multiple time points in a mouse model of optic nerve crush. Firing rate, latency of response and receptive field size were analyzed for ON, OFF and ON-OFF RGCs separately. It was observed that responses and receptive fields of OFF cells were impaired earlier than ON cells after the injury...
June 16, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28629075/fabrication-of-chitosan-au-tio2-nanotube-based-dry-electrodes-for-electroencephalography-recording
#4
Yanjuan Song, Penghai Li, Mingji Li, Hongji Li, Cuiping Li, Dazhi Sun, Baohe Yang
In this paper, we describe a method for fabricating dry electrodes for use in recording electroencephalograms (EEGs), which are based on the use of chitosan (Ch), gold (Au) particles, and titanium dioxide (TiO2) nanotube arrays deposited on titanium (Ti) thin sheets. The samples were characterized by scanning electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and EEG signal collection. The TiO2 nanotube arrays were grown on the Ti thin sheet by an electrochemical anodic oxidation method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628030/a-novel-flexible-cuff-like-microelectrode-for-dual-purpose-acute-and-chronic-electrical-interfacing-with-the-mouse-cervical-vagus-nerve
#5
April Shawn Caravaca, Téa Tsaava, Laura Goldman, Harold Silverman, Gary Riggott, Sangeeta Chavan, Chad Bouton, Kevin J Tracey, Robert Desimone, Ed Boyden, Harbaljit Singh Sohal, Peder S Olofsson
OBJECTIVE: Neural reflexes establish homeostasis and regulate the immune system. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus nerve do not permit effective chronic stimulation or recording in mouse models, which is vital to studying the molecular and neurophysiological mechanisms that control inflammation homeostasis in health and disease...
June 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28612758/recording-nerve-signals-in-canine-sciatic-nerves-with-a-flexible-penetrating-microelectrode-array
#6
Donghak Byun, Sung-Joon Cho, Byeong Han Lee, Joongkee Min, Jong-Hyun Lee, Sohee Kim
OBJECTIVE: Previously, we presented the fabrication and characterization of a flexible penetrating microelectrode array (FPMA) as a neural interface device. In the present study, we aim to prove the feasibility of the developed FPMA as a chronic intrafascicular recording tool for peripheral applications. APPROACH: For recording from the peripheral nerves of medium-sized animals, the FPMA was integrated with an interconnection cable and other parts that were designed to fit canine sciatic nerves...
June 14, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28611486/quantitative-measurements-of-dielectrophoresis-in-a-nanoscale-electrode-array-with-an-atomic-force-microscopy
#7
James Froberg, Vidura Jayasooriya, Seungyong You, Dharmakeerthi Nawarathna, Yongki Choi
Nanoelectronic devices integrated with dielectrophoresis (DEP) have been promoted as promising platforms for trapping, separating, and concentrating target biomarkers and cancer cells from a complex medium. Here, we visualized DEP and DEP gradients in conventional nanoelectronic devices by using multi-pass atomic force microcopy techniques. Our measurements directly demonstrated a short range DEP only at sharp step edges of electrodes, frequency dependent DEP polarity, and separation distance dependent DEP strength...
May 15, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28608907/organs-on-chips-with-combined-multi-electrode-array-and-transepithelial-electrical-resistance-measurement-capabilities
#8
Ben M Maoz, Anna Herland, Olivier Y F Henry, William D Leineweber, Moran Yadid, John Doyle, Robert Mannix, Ville J Kujala, Edward A FitzGerald, Kevin Kit Parker, Donald E Ingber
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electrical resistance (TEER) measurements into the chips during their fabrication. To prove proof-of-concept, simultaneous measurements of cellular electrical activity and tissue barrier function were carried out in a dual channel, endothelialized, heart-on-a-chip device containing human cardiomyocytes and a channel-separating porous membrane covered with a primary human endothelial cell monolayer...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28597847/mapping-the-fine-structure-of-cortical-activity-with-different-micro-ecog-electrode-array-geometries
#9
Xi Wang, Alexis Gkogkidis, Olga Iljina, Lukas Fiederer, Chiristian Henle, Irina Mader, Jan Kaminsky, Thomas Stieglitz, Mortimer Gierthmuehlen, Tonio Ball
OBJECTIVE: Innovations in micro-electrocorticography (µECoG) electrode array manufacturing now allow for intricate designs with smaller contact diameters and/or pitch (i.e., center-to-center contact distance) down to the sub-mm range. The aims of the present study were: (i) to investigate whether frequency ranges up to 400 Hz can be reproducibly observed in µECoG recordings and (ii) to examine how differences in topographical substructure between these frequency bands and electrode array geometries can be quantified...
June 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28586910/corneal-potential-maps-measured-with-multi-electrode-electroretinography-in-rat-eyes-with-experimental-lesions
#10
Zahra Derafshi, Brian E Kunzer, Emily M Mugler, Nataliya Rokhmanova, Dong-Wook Park, Hadi Tajalli, Krithi Shetty, Zhenqiang Ma, Justin C Williams, John R Hetling
Purpose: Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small influence on ERG amplitudes compared to normal ranges. Here we evaluate the use of corneal potential maps obtained in response to full-field flash stimuli for sensitivity to local areas of retinal damage...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28582708/new-immobilisation-method-for-oligonucleotides-on-electrodes-enables-highly-sensitive-electrochemical-label-free-gene-sensing
#11
Nihan Aydemir, Eddie Chan, Paul Baek, David Barker, David E Williams, Jadranka Travas-Sejdic
We present a versatile and facile procedure for the immobilisation of bioprobe molecules to an electrochemical sensing element. We eliminate lengthy preparation procedures for direct functionalisation of electrode surfaces by pre-attaching probe molecules to carboxylic acid bearing termonomers of pyrrole phenylenes or thiophene phenylenes. We demonstrate that these conjugates can be electrodeposited at low potentials to form nano-scale porous, electroactive conducting polymer films, exposing the bioprobe and retaining activity and specificity for binding, exemplified here with DNA sensors...
June 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28582456/detailed-spatial-characterization-of-superficial-hip-muscle-activation-during-walking-a-multi-electrode-surface-emg-investigation-of-the-gluteal-region-in-healthy-older-adults
#12
Christoph Anders, Steffen Patenge, Klaus Sander, Frank Layher, Uta Biedermann, Raimund W Kinne
PURPOSE: A multi-electrode array was used to generate spatially resolved Surface electromyography (SEMG) data of the hip muscles in healthy older adults. The cohort was meant to serve as an age-matched, normal control population for future surgical and rehabilitative studies in patients undergoing total hip arthroplasty, in view of the large, continuously increasing number of hip joint replacements. METHODS: Bilateral hip muscle SEMG activity, including tensor fasciae latae (TFL), gluteus medius (Gmed), and gluteus maximus (Gmax), was measured during locomotion on a walkway at self-selected slow, normal, and fast walking speeds (age-matched cohort of 29 females and 25 males)...
2017: PloS One
https://www.readbyqxmd.com/read/28579632/a-multi-functional-microelectrode-array-featuring-59760-electrodes-2048-electrophysiology-channels-stimulation-impedance-measurement-and-neurotransmitter-detection-channels
#13
Jelena Dragas, Vijay Viswam, Amir Shadmani, Yihui Chen, Raziyeh Bounik, Alexander Stettler, Milos Radivojevic, Sydney Geissler, Marie Obien, Jan Müller, Andreas Hierlemann
Biological cells are characterized by highly complex phenomena and processes that are, to a great extent, interdependent. To gain detailed insights, devices designed to study cellular phenomena need to enable tracking and manipulation of multiple cell parameters in parallel; they have to provide high signal quality and high spatiotemporal resolution. To this end, we have developed a CMOS-based microelectrode array system that integrates six measurement and stimulation functions, the largest number to date. Moreover, the system features the largest active electrode array area to date (4...
June 2017: IEEE Journal of Solid-state Circuits
https://www.readbyqxmd.com/read/28574350/characterization-of-kerfless-linear-arrays-based-on-pzt-thick-film
#14
Tomasz Zawada, Louise Bierregaard, Erling Ringgaard, Ruichao Xu, Michele Guizzetti, Franck Levassort, Dominique Certon
Multi-element transducers enabling novel cost-effective fabrication of imaging arrays for medical applications have been presented earlier. Due to the favorable low lateral coupling of the screen-printed PZT, the elements can be defined by the top electrode pattern only, leading to a kerfless design with low cross-talk between the elements. The thick-film based linear arrays have proved to be compatible with a commercial ultrasonic scanner and to support linear array beamforming as well as phased array beamforming...
May 26, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28570546/electrophysiological-analysis-of-human-pluripotent-stem-cell-derived-cardiomyocytes-hpsc-cms-using-multi-electrode-arrays-meas
#15
Luca Sala, Dorien Ward-van Oostwaard, Leon G J Tertoolen, Christine L Mummery, Milena Bellin
Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling cardiovascular diseases in humans, especially arrhythmia syndromes. They have also demonstrated relevance as in vitro systems for predicting drug responses, which makes them potentially useful for drug-screening and discovery, safety pharmacology and perhaps eventually for personalized medicine...
May 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28566464/activation-of-ganglion-cells-and-axon-bundles-using-epiretinal-electrical-stimulation
#16
Lauren E Grosberg, Karthik Ganesan, Georges A Goetz, Sasidhar S Madugula, Nandita Bhaskhar, Victoria Fan, Peter Li, Pawel Hottowy, Wladyslaw Dabrowski, Alexander Sher, Alan M Litke, Subhasish Mitra, E J Chichilnisky
Epiretinal prostheses for treating blindness activate axon bundles, causing large, arc-shaped visual percepts that limit the quality of artificial vision. Improving the function of epiretinal prostheses therefore requires understanding and avoiding axon bundle activation. This paper introduces a method to detect axon bundle activation based on its electrical signature, and uses the method to test whether epiretinal stimulation can directly elicit spikes in individual retinal ganglion cells without activating nearby axon bundles...
May 31, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28559791/photogrammetry-based-head-digitization-for-rapid-and-accurate-localization-of-eeg-electrodes-and-meg-fiducial-markers-using-a-single-digital-slr-camera
#17
Tommy Clausner, Sarang S Dalal, Maité Crespo-García
The performance of EEG source reconstruction has benefited from the increasing use of advanced head modeling techniques that take advantage of MRI together with the precise positions of the recording electrodes. The prevailing technique for registering EEG electrode coordinates involves electromagnetic digitization. However, the procedure adds several minutes to experiment preparation and typical digitizers may not be accurate enough for optimal source reconstruction performance (Dalal et al., 2014). Here, we present a rapid, accurate, and cost-effective alternative method to register EEG electrode positions, using a single digital SLR camera, photogrammetry software, and computer vision techniques implemented in our open-source toolbox, janus3D...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28552957/safety-and-eeg-data-quality-of-concurrent-high-density-eeg-and-high-speed-fmri-at-3-tesla
#18
Mette Thrane Foged, Ulrich Lindberg, Kishore Vakamudi, Henrik B W Larsson, Lars H Pinborg, Troels W Kjær, Martin Fabricius, Claus Svarer, Brice Ozenne, Carsten Thomsen, Sándor Beniczky, Olaf B Paulson, Stefan Posse
PURPOSE: Concurrent EEG and fMRI is increasingly used to characterize the spatial-temporal dynamics of brain activity. However, most studies to date have been limited to conventional echo-planar imaging (EPI). There is considerable interest in integrating recently developed high-speed fMRI methods with high-density EEG to increase temporal resolution and sensitivity for task-based and resting state fMRI, and for detecting interictal spikes in epilepsy. In the present study using concurrent high-density EEG and recently developed high-speed fMRI methods, we investigate safety of radiofrequency (RF) related heating, the effect of EEG on cortical signal-to-noise ratio (SNR) in fMRI, and assess EEG data quality...
2017: PloS One
https://www.readbyqxmd.com/read/28549786/action-potential-based-mea-platform-for-in-vitro-screening-of-drug-induced-cardiotoxicity-using-human-ipscs-and-rat-neonatal-myocytes
#19
Danny Jans, Geert Callewaert, Olga Krylychkina, Luis Hoffman, Francesco Gullo, Dimiter Prodanov, Dries Braeken
Drug-induced cardiotoxicity poses a negative impact on public health and drug development. Cardiac safety pharmacology issues urged for the preclinical assessment of drug-induced ventricular arrhythmia leading to the design of several in vitro electrophysiological screening assays. In general, patch clamp systems allow for intracellular recordings, while multi-electrode array (MEA) technology detect extracellular activity. Here, we demonstrate a complementary metal oxide semiconductor (CMOS)-based MEA system as a reliable platform for non-invasive, long-term intracellular recording of cardiac action potentials at high resolution...
May 23, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28493886/narrow-microtunnel-technology-for-the-isolation-and-precise-identification-of-axonal-communication-among-distinct-hippocampal-subregion-networks
#20
Udit Narula, Andres Ruiz, McKinley McQuaide, Thomas B DeMarse, Bruce C Wheeler, Gregory J Brewer
Communication between different sub regions of the hippocampus is fundamental to learning and memory. However accurate knowledge about information transfer between sub regions from access to the activity in individual axons is lacking. MEMS devices with microtunnels connecting two sub networks have begun to approach this problem but the commonly used 10 μm wide tunnels frequently measure signals from multiple axons. To reduce this complexity, we compared polydimethylsiloxane (PDMS) microtunnel devices each with a separate tunnel width of 2...
2017: PloS One
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