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Multi-electrode array

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https://www.readbyqxmd.com/read/27900949/prediction-of-cortical-responses-to-simultaneous-electrical-stimulation-of-the-retina
#1
Kerry J Halupka, Mohit N Shivdasani, Shaun L Cloherty, David B Grayden, Yan T Wong, Anthony N Burkitt, Hamish Meffin
OBJECTIVE: Simultaneous electrical stimulation of multiple electrodes has shown promise in diversifying the responses that can be elicited by retinal prostheses compared to interleaved single electrode stimulation. However, the effects of interactions between electrodes are not well understood and clinical trials with simultaneous stimulation have produced inconsistent results. We investigated the effects of multiple electrode stimulation of the retina by developing a model of cortical responses to retinal stimulation...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27891080/enhanced-burst-suppression-and-disruption-of-local-field-potential-synchrony-in-a-mouse-model-of-focal-cortical-dysplasia-exhibiting-spike-wave-seizures
#2
Anthony J Williams, Chen Zhou, Qian-Quan Sun
Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays were used to record extracellular potentials from cortical and subcortical brain regions near the FL in anesthetized mice (5-13 months old) followed by 24 h cortical electroencephalogram (EEG) recordings...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27878736/in-vitro-cyto-biocompatibility-study-of-thin-film-transistors-substrates-using-an-organotypic-culture-method
#3
Eric Leclerc, Jean-Luc Duval, Christophe Egles, Satoshi Ihida, Hiroshi Toshiyoshi, Agnès Tixier-Mita
Thin-Film-Transistors Liquid-Crystal Display has become a standard in the field of displays. However, the structure of these devices presents interest not only in that field, but also for biomedical applications. One of the key components, called here TFT substrate, is a glass substrate with a dense and large array of thousands of transparent micro-electrodes that can be considered as a large scale multi-electrode array(s). Multi-electrode array(s) are widely used for in vitro electrical investigations on neurons and brain, allowing excitation, registration, and recording of their activity...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27831887/modeling-intracochlear-magnetic-stimulation-a-finite-element-analysis
#4
Sagarika Mukesh, D T Blake, B J McKinnon, P T Bhatti
This study models induced electric fields, and their gradient, produced by pulsatile current stimulation of submillimeter inductors for cochlear implantation. Using finite-element analysis, the lower chamber of the cochlea, scala tympani, is modeled as a cylindrical structure filled with perilymph bounded by tissue, bone, and cochlear neural elements. Single inductors as well as an array of inductors are modeled. The coil strength (~100 nH) and excitation parameters (Peak current of 1 - 5 A, Voltages of 16 - 20 V) are based on a formative feasibility study conducted by our group...
November 2, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27831884/active-control-of-dye-release-for-neuronal-tracing-using-pedot-pss-coated-electrodes
#5
Stefanie Heizmann, Antje Kilias, Patrick Ruther, Ulrich Egert, Maria Asplund
Penetrating neural probes comprising arrays of microelectrodes are commonly used to monitor local field potentials and multi-unit activity in animal brain over time frames of weeks. To correlate these recorded signals to specific tissue areas, histological analysis is performed after the experimental endpoint. Even if the lesion of the penetrating probe shaft can be observed, a precise reconstruction of the exact electrode positions is still challenging. To overcome these experimental difficulties, we developed a new concept, whereupon recording electrodes are coated with a poly (3, 4-ethylenedioxythiophene/ polystyrenesulfonate) (PEDOT/PSS)-based film...
October 31, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27830452/fabrication-of-self-expandable-niti-thin-film-devices-with-micro-electrode-array-for-bioelectric-sensing-stimulation-and-ablation
#6
Christoph Bechtold, Rodrigo Lima de Miranda, Christoph Chluba, Eckhard Quandt
Self-expandable medical devices provide mechanical functionality at a specific location of the human body and are viable for minimal invasive procedures. Besides radiopaque markers and drug-eluting coatings, next generation self-expandable devices can be equipped with additional functionality, such as conductive and flexible electrodes, which enables chronic recording of bioelectrical signals, stimulating or ablating tissue. This promises new therapeutic options in various medical fields, among them in particular neuromodulation (e...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27824075/simultaneous-multi-patch-clamp-and-extracellular-array-recordings-single-neuron-reflects-network-activity
#7
Roni Vardi, Amir Goldental, Shira Sardi, Anton Sheinin, Ido Kanter
The increasing number of recording electrodes enhances the capability of capturing the network's cooperative activity, however, using too many monitors might alter the properties of the measured neural network and induce noise. Using a technique that merges simultaneous multi-patch-clamp and multi-electrode array recordings of neural networks in-vitro, we show that the membrane potential of a single neuron is a reliable and super-sensitive probe for monitoring such cooperative activities and their detailed rhythms...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818043/ultrasensitive-nanostructure-sensor-arrays-on-flexible-substrates-for-multiplexed-and-simultaneous-electrochemical-detection-of-a-panel-of-cardiac-biomarkers
#8
Nandhinee Radha Shanmugam, Sriram Muthukumar, Shajee Chaudhry, Jonathan Anguiano, Shalini Prasad
Multiplexed detection of protein biomarkers offers new opportunities for early diagnosis and efficient treatment of complex diseases. Cardiovascular diseases (CVDs) has the highest mortality risk in USA and Europe with 15-20 million cases being reported annually. Cardiac Troponins (T and I) are well established protein biomarkers associated with heart muscle damage and point-of-care monitoring of both these two biomarkers has significant benefits on patient care. A flexible disposable electrochemical biosensor device comprising of vertically oriented zinc oxide (ZnO) nanostructures was developed for rapid and simultaneous screening of cardiac Troponin-I (cTnI) and cardiac-Troponin-T (cTnT) in a point-of-care sensor format...
October 20, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27805613/spiral-ganglion-neuron-explant-culture-and-electrophysiology-on-multi-electrode-arrays
#9
Stefan Hahnewald, Marta Roccio, Anne Tscherter, Jürg Streit, Ranjeeta Ambett, Pascal Senn
Spiral ganglion neurons (SGNs) participate in the physiological process of hearing by relaying signals from sensory hair cells to the cochlear nucleus in the brain stem. Loss of hair cells is a major cause of sensory hearing loss. Prosthetic devices such as cochlear implants function by bypassing lost hair cells and directly stimulating SGNs electrically, allowing for restoration of hearing in deaf patients. The performance of these devices depends on the functionality of SGNs, the implantation procedure and on the distance between the electrodes and the auditory neurons...
October 19, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27786252/cortical-neurons-of-bats-respond-best-to-echoes-from-nearest-targets-when-listening-to-natural-biosonar-multi-echo-streams
#10
M Jerome Beetz, Julio C Hechavarría, Manfred Kössl
Bats orientate in darkness by listening to echoes from their biosonar calls, a behaviour known as echolocation. Recent studies showed that cortical neurons respond in a highly selective manner when stimulated with natural echolocation sequences that contain echoes from single targets. However, it remains unknown how cortical neurons process echolocation sequences containing echo information from multiple objects. In the present study, we used echolocation sequences containing echoes from three, two or one object separated in the space depth as stimuli to study neuronal activity in the bat auditory cortex...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27759367/hybrid-energy-cell-with-hierarchical-nano-micro-architectured-polymer-film-to-individually-simultaneously-harvest-mechanical-solar-and-wind-energies
#11
Bhaskar Dudem, Yeong Hwan Ko, Jung Woo Leem, Joo Ho Lim, Jae Su Yu
We report the hierarchical nano/micro architectured (HNMA)-polydimethylsiloxane (PDMS) film-based hybrid energy cells with multi-functionality to simultaneously harvest mechanical, solar, and wind energies. These films consist of nano/micro dual-scale architectures (i.e., nanonipples on inverted micro pyramidal arrays) on the PDMS surface. The HNMA-PDMS is replicable by a facile and cost-effective soft imprint lithography (SIL) using a nanoporous anodic alumina oxide (AAO) film formed on the micro-pyramidal (MP) structured silicon substrate...
October 19, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27736070/iridium-oxide-electrodeposited-nanoporous-gold-multi-electrode-array-with-enhanced-stimulus-efficacy
#12
Yong Hee Kim, Gook Hwa Kim, Min Sun Kim, Sang-Don Jung
A Multi-electrode array (MEA) was fabricated with electrodes consisting of iridium oxide (IrOx) electrochemically deposited on nanoporous gold (NPG) to improve the moderate charge injection limit (ca. 1 mC cm-2) of NPG MEA. IrOx was electrodeposited by performing cyclic voltammetry with an IrOx deposition solution. The IrOx was electrodeposited on Au (EIROF/Au) and on NPG (EIROF/NPG) MEA, and the samples were analyzed in terms of the charge injection limit, charge storage capacity (CSC), and electrochemical impedance...
October 13, 2016: Nano Letters
https://www.readbyqxmd.com/read/27735935/fabrication-and-utility-of-a-transparent-graphene-neural-electrode-array-for-electrophysiology-in-vivo-imaging-and-optogenetics
#13
Dong-Wook Park, Sarah K Brodnick, Jared P Ness, Farid Atry, Lisa Krugner-Higby, Amelia Sandberg, Solomon Mikael, Thomas J Richner, Joseph Novello, Hyungsoo Kim, Dong-Hyun Baek, Jihye Bong, Seth T Frye, Sanitta Thongpang, Kyle I Swanson, Wendell Lake, Ramin Pashaie, Justin C Williams, Zhenqiang Ma
Transparent graphene-based neural electrode arrays provide unique opportunities for simultaneous investigation of electrophysiology, various neural imaging modalities, and optogenetics. Graphene electrodes have previously demonstrated greater broad-wavelength transmittance (∼90%) than other transparent materials such as indium tin oxide (∼80%) and ultrathin metals (∼60%). This protocol describes how to fabricate and implant a graphene-based microelectrocorticography (μECoG) electrode array and subsequently use this alongside electrophysiology, fluorescence microscopy, optical coherence tomography (OCT), and optogenetics...
November 2016: Nature Protocols
https://www.readbyqxmd.com/read/27720795/chronic-14-day-exposure-to-insecticides-or-methylmercury-modulates-neuronal-activity-in-primary-rat-cortical-cultures
#14
Milou M L Dingemans, Marijke G Schütte, Daphne M M Wiersma, Aart de Groot, Regina G D M van Kleef, Fiona M J Wijnolts, Remco H S Westerink
There is an increasing demand for in vitro test systems to detect neurotoxicity for use in chemical risk assessment. In this study, we evaluated the applicability of rat primary cortical cultures grown on multi-well micro-electrode arrays (mwMEAs) to detect effects of chronic 14-day exposure to structurally different insecticides or methylmercury on neuronal activity (mean spike rate; MSR). Effects of chronic exposure to α-cypermethrin, endosulfan, carbaryl, chlorpyrifos(-oxon), methylmercury or solvent control [14days exposure, initiated after baseline recording at day in vitro (DIV)7] were studied in five successive recordings between DIV10 and DIV21...
October 5, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27708562/embryonic-cell-grafts-in-a-culture-model-of-spinal-cord-lesion-neuronal-relay-formation-is-essential-for-functional-regeneration
#15
Anne Tscherter, Martina Heidemann, Sonja Kleinlogel, Jürg Streit
Presently there exists no cure for spinal cord injury (SCI). However, transplantation of embryonic tissue into spinal cord (SC) lesions resulted in axon outgrowth across the lesion site and some functional recovery, fostering hope for future stem cell therapies. Although in vivo evidence for functional recovery is given, the exact cellular mechanism of the graft support remains elusive: either the grafted cells provide a permissive environment for the host tissue to regenerate itself or the grafts actually integrate functionally into the host neuronal network reconnecting the separated SC circuits...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27705958/chronic-in-vivo-stability-assessment-of-carbon-fiber-microelectrode-arrays
#16
Paras R Patel, Huanan Zhang, Matthew T Robbins, Justin B Nofar, Shaun P Marshall, Michael J Kobylarek, Takashi D Y Kozai, Nicholas A Kotov, Cynthia A Chestek
OBJECTIVE: Individual carbon fiber microelectrodes can record unit activity in both acute and semi-chronic (∼1 month) implants. Additionally, new methods have been developed to insert a 16 channel array of carbon fiber microelectrodes. Before assessing the in vivo long-term viability of these arrays, accelerated soak tests were carried out to determine the most stable site coating material. Next, a multi-animal, multi-month, chronic implantation study was carried out with carbon fiber microelectrode arrays and silicon electrodes...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27694698/selective-in-situ-potential-assisted-sam-formation-on-multi-electrode-arrays
#17
Ann-Lauriene Haag, Violeta Toader, R Bruce Lennox, Peter Grutter
The selective modification of individual components in a biosensor array is challenging. To address this challenge, we present a generalizable approach to selectively modify and characterize individual gold surfaces in an array, in an in situ manner. This is achieved by taking advantage of the potential dependent adsorption/desorption of surface-modified organic molecules. Control of the applied potential of the individual sensors in an array where each acts as a working electrode provides differential derivatization of the sensor surfaces...
November 11, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27686511/insufficient-developmental-excitatory-neuronal-activity-fails-to-foster-establishment-of-normal-levels-of-inhibitory-neuronal-activity
#18
Mikaela Therrien, Rishel Vohnoutka, Edward Boumil, Mary Guaraldi, Sangmook Lee, Thomas B Shea
The nervous system is composed of excitatory and inhibitory neurons. One major class of inhibitory neurons release the neurotransmitter γ-Aminobutyric acid (GABA). GABAergic inhibitory activity maintains the balance that is disrupted in conditions such as epilepsy. At least some GABAergic neurons are initially excitatory and undergo a developmental conversion to convert to inhibitory neurons. The mechanism(s) behind this conversion are thought to include a critical developmental increase in excitatory activity...
September 26, 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27683885/neuron-glia-cross-talk-revealed-in-reverberating-networks-by-simultaneous-extracellular-recording-of-spikes-and-astrocytes-glutamate-transporter-and-k-currents
#19
Enzo Wanke, Francesca Gullo, Elena Dossi, Gaetano Valenza, Andrea Becchetti
Astrocytes uptake synaptically released glutamate with electrogenic transporters (GluT) and buffer the spike-dependent extracellular K(+) excess with background K(+) channels. We studied neuronal spikes and the slower astrocytic signals on reverberating neocortical cultures and organotypic slices from mouse brains. Spike trains and glial responses were simultaneously captured from individual sites of multielectrode arrays (MEA) by splitting the recorded traces into appropriate filters and reconstructing the original signal by deconvolution...
December 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27682412/design-and-application-of-multi-functional-electrogenerated-chemiluminescence-imaging-analyzer
#20
Guangfu Jiang, Xia Liu, Yaqin Wang, Sanpeng Ruan, Honglan Qi, Yong Yang, Qishe Zhou, Chengxiao Zhang
A multi-functional eletrogenerated chemiluminescence (ECL) imaging analyzer including both a photomultiplier tube and charged coupled device as detectors has been developed. The ECL imaging analyzer can effectively work for electrochemical study, ECL intensity detection at electrode array, and ECL imaging at bipolar electrodes or electrode array. As an ECL imaging example, an ECL biosensor for visual detection of matrix metalloproteinase 7 in the range from 0.05 to 1 ng/mL is demonstrated.
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
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