keyword
MENU ▼
Read by QxMD icon Read
search

Multi-electrode array

keyword
https://www.readbyqxmd.com/read/28493886/narrow-microtunnel-technology-for-the-isolation-and-precise-identification-of-axonal-communication-among-distinct-hippocampal-subregion-networks
#1
Udit Narula, Andres Ruiz, McKinley McQuaide, Thomas B DeMarse, Bruce C Wheeler, Gregory J Brewer
Communication between different sub regions of the hippocampus is fundamental to learning and memory. However accurate knowledge about information transfer between sub regions from access to the activity in individual axons is lacking. MEMS devices with microtunnels connecting two sub networks have begun to approach this problem but the commonly used 10 μm wide tunnels frequently measure signals from multiple axons. To reduce this complexity, we compared polydimethylsiloxane (PDMS) microtunnel devices each with a separate tunnel width of 2...
2017: PloS One
https://www.readbyqxmd.com/read/28458635/analysis-and-modeling-of-subthreshold-neural-multi-electrode-array-data-by-statistical-field-theory
#2
Måns Henningson, Sebastian Illes
Multi-electrode arrays (MEA) are increasingly used to investigate spontaneous neuronal network activity. The recorded signals comprise several distinct components: Apart from artifacts without biological significance, one can distinguish between spikes (action potentials) and subthreshold fluctuations (local fields potentials). Here we aim to develop a theoretical model that allows for a compact and robust characterization of subthreshold fluctuations in terms of a Gaussian statistical field theory in two spatial and one temporal dimension...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28458040/temporal-and-spatial-dynamics-of-peripheral-afferent-evoked-activity-in-the-dorsal-horn-recorded-in-rat-spinal-cord-slices
#3
Fang Yu, Zhen-Yu Zhao, Ting He, Yao-Qing Yu, Zhen Li, Jun Chen
In the present study, multi-electrode array recording was used to examine dorsal horn activity following stimulation of primary afferents in a rat dorsal root attached-spinal cord slice preparation. The multi-electrode array probe was placed under the dorsal horn slice and local field potentials evoked by stimulation on the dorsal root were analyzed. Three kinds of dorsal root-evoked responses were identified. In lamina IIo, local field potentials exhibited P1 (peak latency 1.46±0.08ms), N1 (2.77±0.18ms, n=12), N2 (7...
April 27, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28456566/assessment-of-acute-and-chronic-toxicity-of-doxorubicin-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#4
Jochem Louisse, Rob C I Wüst, Francesca Pistollato, Taina Palosaari, Manuela Barilari, Peter Macko, Susanne Bremer, Pilar Prieto
The present study assesses acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), with the aim to obtain in vitro biomarkers that can be used as readouts to predict in vivo cardiotoxicity. Possible acute toxicity was investigated by assessing effects on the beating rate and the field potential duration (FPD) of doxorubicin-exposed cardiomyocytes by measuring electrical activity using multi-electrode array (MEA) analyses. No effects on the beating rate and FPD were found at concentrations up to 6μM, whereas at 12μM no electrical activity was recorded, indicating that the cardiomyocytes stopped beating...
April 26, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28439233/concealed-unobtrusive-ear-centered-eeg-acquisition-ceegrids-for-transparent-eeg
#5
Martin G Bleichner, Stefan Debener
Electroencephalography (EEG) is an important clinical tool and frequently used to study the brain-behavior relationship in humans noninvasively. Traditionally, EEG signals are recorded by positioning electrodes on the scalp and keeping them in place with glue, rubber bands, or elastic caps. This setup provides good coverage of the head, but is impractical for EEG acquisition in natural daily-life situations. Here, we propose the transparent EEG concept. Transparent EEG aims for motion tolerant, highly portable, unobtrusive, and near invisible data acquisition with minimum disturbance of a user's daily activities...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28436835/neural-spike-train-synchronisation-indices-definitions-interpretations-and-applications
#6
D M Halliday, J R Rosenberg
A comparison of previously defined spike train syncrhonization indices is undertaken within a stochastic point process framework. The second order cumulant density (covariance density) is shown to be common to all the indices. Simulation studies were used to investigate the sampling variability of a single index based on the second order cumulant. The simulations used a paired motoneurone model and a paired regular spiking cortical neurone model. The sampling variability of spike trains generated under identical conditions from the paired motoneurone model varied from 50% { 160% of the estimated value...
April 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28424292/loss-and-recovery-of-functional-connectivity-in-cultured-cortical-networks-exposed-to-hypoxia
#7
Joost le Feber, Niels Erkamp, Michel J A M van Putten, Jeannette Hofmeijer
In the core of a brain infarct, loss of neuronal function is followed by neuronal death within minutes. In an area surrounding the core (penumbra), some perfusion remains. Here, neurons initially remain structurally intact, but massive synaptic failure strongly reduces neural activity. Activity in the penumbra may eventually recover or further deteriorate towards massive cell death. Besides activity recovery, return of brain functioning requires restoration of connectivity. However, low activity has been shown to initiate compensatory mechanisms that affect network connectivity...
April 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28413199/rapid-and-coordinated-processing-of-global-motion-images-by-local-clusters-of-retinal-ganglion-cells
#8
Akihiro Matsumoto, Masao Tachibana
Even when the body is stationary, the whole retinal image is always in motion by fixational eye movements and saccades that move the eye between fixation points. Accumulating evidence indicates that the brain is equipped with specific mechanisms for compensating for the global motion induced by these eye movements. However, it is not yet fully understood how the retina processes global motion images during eye movements. Here we show that global motion images evoke novel coordinated firing in retinal ganglion cells (GCs)...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28377112/the-assessment-of-electrophysiological-activity-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-exposed-to-dimethyl-sulfoxide-and-ethanol-by-manual-patch-clamp-and-multi-electrode-array-system
#9
Soo-Wang Hyun, Bo-Ram Kim, Sung-Ae Hyun, Joung-Wook Seo
INTRODUCTION: Recently, electrophysiological activity has been effectively measured in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to predict drug-induced arrhythmia. Dimethyl sulfoxide (DMSO) and ethanol have been used as diluting agents in many experiments. However, the maximum DMSO and ethanol concentrations that can be effectively used in the measurement of electrophysiological parameters in hiPSC-CMs-based patch clamp and multi-electrode array (MEA) have not been fully elucidated...
April 1, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28367117/representation-of-glossy-material-surface-in-ventral-superior-temporal-sulcal-area-of-common-marmosets
#10
Naohisa Miyakawa, Taku Banno, Hiroshi Abe, Toshiki Tani, Wataru Suzuki, Noritaka Ichinohe
The common marmoset (Callithrix jacchus) is one of the smallest species of primates, with high visual recognition abilities that allow them to judge the identity and quality of food and objects in their environment. To address the cortical processing of visual information related to material surface features in marmosets, we presented a set of stimuli that have identical three-dimensional shapes (bone, torus or amorphous) but different material appearances (ceramic, glass, fur, leather, metal, stone, wood, or matte) to anesthetized marmoset, and recorded multiunit activities from an area ventral to the superior temporal sulcus (STS) using multi-shanked, and depth resolved multi-electrode array...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28363483/restoration-of-reaching-and-grasping-movements-through-brain-controlled-muscle-stimulation-in-a-person-with-tetraplegia-a-proof-of-concept-demonstration
#11
A Bolu Ajiboye, Francis R Willett, Daniel R Young, William D Memberg, Brian A Murphy, Jonathan P Miller, Benjamin L Walter, Jennifer A Sweet, Harry A Hoyen, Michael W Keith, P Hunter Peckham, John D Simeral, John P Donoghue, Leigh R Hochberg, Robert F Kirsch
BACKGROUND: People with chronic tetraplegia, due to high-cervical spinal cord injury, can regain limb movements through coordinated electrical stimulation of peripheral muscles and nerves, known as functional electrical stimulation (FES). Users typically command FES systems through other preserved, but unrelated and limited in number, volitional movements (eg, facial muscle activity, head movements, shoulder shrugs). We report the findings of an individual with traumatic high-cervical spinal cord injury who coordinated reaching and grasping movements using his own paralysed arm and hand, reanimated through implanted FES, and commanded using his own cortical signals through an intracortical brain-computer interface (iBCI)...
May 6, 2017: Lancet
https://www.readbyqxmd.com/read/28324940/use-of-local-field-potentials-of-dissociated-cultures-grown-on-multi-electrode-arrays-for-pharmacological-assays
#12
G D C Mendis, E Morrisroe, C A Reid, S K Halgamuge, S Petrou
In vitro Multi-Electrode Arrays (MEA) are an extracellular recording technology that enables the analysis of networks of neurons in vitro. Neurons in culture exhibit a range of behavioral dynamics, which can be measured in terms of individual action potentials, network-wide synchronized firing and a host of other features that characterize network activity. MEA data analysis was historically focused on high frequency spike data forgoing the low frequency content of the signal. In this study, we use local field potentials, which are low frequency components of MEA signals, to differentiate between two types of antiepileptic drugs (p<;0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322793/temporal-relation-between-neural-activity-and-neurite-pruning-on-a-numerical-model-and-a-microchannel-device-with-micro-electrode-array
#13
Yohei Kondo, Yuichiro Yada, Tatsuya Haga, Yuzo Takayama, Takuya Isomura, Yasuhiko Jimbo, Osamu Fukayama, Takayuki Hoshino, Kunihiko Mabuchi
Synapse elimination and neurite pruning are essential processes for the formation of neuronal circuits. These regressive events depend on neural activity and occur in the early postnatal days known as the critical period, but what makes this temporal specificity is not well understood. One possibility is that the neural activities during the developmentally regulated shift of action of GABA inhibitory transmission lead to the critical period. Moreover, it has been reported that the shifting action of the inhibitory transmission on immature neurons overlaps with synapse elimination and neurite pruning and that increased inhibitory transmission by drug treatment could induce temporal shift of the critical period...
March 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28321048/evaluation-of-the-effects-of-power-frequency-magnetic-fields-on-the-electrical-activity-of-cardiomyocytes-differentiated-from-human-induced-pluripotent-stem-cells
#14
Masayuki Takahashi, Atsushi Saito, Yasuhiko Jimbo, Satoshi Nakasono
Although cardiac activity is known to differ between species in many respects, most evaluations of the cardiac effects of low-frequency electric and magnetic fields, which have a stimulant effect on electrically activated cells, have been performed in non-human experimental animals and cells, and the effects in humans have been assessed using theoretical models. In recent years, it has been verified that human cardiomyocytes differentiated from human induced pluripotent stem cells (hiPS-CM) are useful for evaluating human responses to various cardioactive compounds...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28321045/characterization-of-human-ips-cell-derived-cardiomyocyte-sheets-as-a-model-to-detect-drug-induced-conduction-disturbance
#15
Hiroko Izumi-Nakaseko, Yuji Nakamura, Takeshi Wada, Kentaro Ando, Yasunari Kanda, Yuko Sekino, Atsushi Sugiyama
In order to characterize human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets as a model for detecting drug-induced conduction disturbance, we examined their electrophysiological and electropharmacological properties by using the multi-electrode array system with a programmed electrical stimulation protocol. At pre-drug control, the conduction speed, effective refractory period and field potential duration were 0.14 ± 0.01 m/sec, 453 ± 10 msec and 361 ± 9 msec, respectively at a cycle length of 1,000 msec (n = 18)...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28317836/microscale-symmetrical-electroporator-array-as-a-versatile-molecular-delivery-system
#16
Mengxing Ouyang, Winfield Hill, Jung Hyun Lee, Soojung Claire Hur
Successful developments of new therapeutic strategies often rely on the ability to deliver exogenous molecules into cytosol. We have developed a versatile on-chip vortex-assisted electroporation system, engineered to conduct sequential intracellular delivery of multiple molecules into various cell types at low voltage in a dosage-controlled manner. Micro-patterned planar electrodes permit substantial reduction in operational voltages and seamless integration with an existing microfluidic technology. Equipped with real-time process visualization functionality, the system enables on-chip optimization of electroporation parameters for cells with varying properties...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303939/integrated-multi-ise-arrays-with-improved-sensitivity-accuracy-and-precision
#17
Chunling Wang, Hongyan Yuan, Zhijuan Duan, Dan Xiao
Increasing use of ion-selective electrodes (ISEs) in the biological and environmental fields has generated demand for high-sensitivity ISEs. However, improving the sensitivities of ISEs remains a challenge because of the limit of the Nernstian slope (59.2/n mV). Here, we present a universal ion detection method using an electronic integrated multi-electrode system (EIMES) that bypasses the Nernstian slope limit of 59.2/n mV, thereby enabling substantial enhancement of the sensitivity of ISEs. The results reveal that the response slope is greatly increased from 57...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28287541/a-visual-guide-to-sorting-electrophysiological-recordings-using-spikesorter
#18
Nicholas V Swindale, Catalin Mitelut, Timothy H Murphy, Martin A Spacek
Few stand-alone software applications are available for sorting spikes from recordings made with multi-electrode arrays. Ideally, an application should be user friendly with a graphical user interface, able to read data files in a variety of formats, and provide users with a flexible set of tools giving them the ability to detect and sort extracellular voltage waveforms from different units with some degree of reliability. Previously published spike sorting methods are now available in a software program, SpikeSorter, intended to provide electrophysiologists with a complete set of tools for sorting, starting from raw recorded data file and ending with the export of sorted spikes times...
February 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28284918/intracortical-microstimulation-differentially-activates-cortical-layers-based-on-stimulation-depth
#19
Mathias Benjamin Voigt, Peter Hubka, Andrej Kral
BACKGROUND: Intracortical microstimulation is one of the most common techniques to causally interfere with neuronal processing, but neuronal recordings spanning the whole cortical depth during stimulation are exceptionally rare. OBJECTIVE/HYPOTHESIS: Here we combined layer-specific intracortical microstimulation with extracellular recordings on the same shank of a linear multi-electrode array to study the effects of electrical stimulation in different cortical depths on intracortical processing in the auditory cortex in vivo...
May 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28280466/embryonic-stem-cell-derived-neurons-grown-on-multi-electrode-arrays-as-a-novel-in-vitro-bioassay-for-the-detection-of-clostridium-botulinum-neurotoxins
#20
Stephen P Jenkinson, Denis Grandgirard, Martina Heidemann, Anne Tscherter, Marc-André Avondet, Stephen L Leib
Clostridium botulinum neurotoxins (BoNTs) are the most poisonous naturally occurring protein toxins known to mankind and are the causative agents of the severe and potentially life-threatening disease botulism. They are also known for their application as cosmetics and as unique bio-pharmaceuticals to treat an increasing number of neurological and non-neurological disorders. Currently, the potency of biologically active BoNT for therapeutic use is mainly monitored by the murine LD50-assay, an ethically disputable test causing suffering and death of a considerable number of mice...
2017: Frontiers in Pharmacology
keyword
keyword
85457
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"