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Multi-electrode array

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https://www.readbyqxmd.com/read/28717833/an-interdigital-array-microelectrode-aptasensor-based-on-multi-walled-carbon-nanotubes-for-detection-of-tetracycline
#1
Wenjie Hou, Zhaoqiang Shi, Yemin Guo, Xia Sun, Xiangyou Wang
In this study an impedance aptasensor was designed for sensitive, selective, and fast detection of tetracycline (TET) based on an interdigital array microelectrode (IDAM). The IDAM was integrated with impedance detection to miniaturize the conventional electrodes, enhance the sensitivity, shorten the detection time, and minimize interfering effects of non-target analytes in the solution. Due to their excellent conductivity, good biocompatibility, the multi-walled carbon nanotubes (MWCNTs) were used to modify the IDAM to immobilize TET aptamer effectively...
July 17, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28708891/loss-of-neuroligin3-specifically-downregulates-retinal-gabaa%C3%AE-2-receptors-without-abolishing-direction-selectivity
#2
Mrinalini Hoon, Vidhyasankar Krishnamoorthy, Tim Gollisch, Bjoern Falkenburger, Frederique Varoqueaux
The postsynaptic adhesion proteins Neuroligins (NLs) are essential for proper synapse function, and their alterations are associated with a variety of neurodevelopmental disorders. It is increasingly clear that each NL isoform occupies specific subsets of synapses and is able to regulate the function of discrete networks. Studies of NL2 and NL4 in the retina in particular have contributed towards uncovering their role in inhibitory synapse function. In this study we show that NL3 is also predominantly expressed at inhibitory postsynapses in the retinal inner plexiform layer (IPL), where it colocalizes with both GABAA- and glycinergic receptor clusters in a 3:2 ratio...
2017: PloS One
https://www.readbyqxmd.com/read/28698637/distinct-properties-of-long-term-potentiation-in-the-dentate-gyrus-along-the-dorsoventral-axis-influence-of-age-and-inhibition
#3
An Schreurs, Victor Sabanov, Detlef Balschun
The hippocampus is important for spatial navigation, episodic memory and affective behaviour. Increasing evidence suggests that these multiple functions are accomplished by different segments along the dorsal-ventral (septal-temporal) axis. Long-term potentiation (LTP), the best-investigated cellular correlate of learning and memory, has distinct properties along this axis in the CA1 region, but so far, little is known about longitudinal differences in dentate gyrus (DG). Therefore, here we examined potential dorsoventral differences in DG-LTP using in vitro multi-electrode array recordings...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28682082/nanoelectronic-coating-enabled-versatile-multi-functional-neural-probes
#4
Zhengtuo Zhao, Lan Luan, Xiaoling Wei, Hanlin Zhu, Xue Li, Shengqing Lin, Jennifer J Siegel, Raymond A Chitwood, Chong Xie
Brain function can be best studied by simultaneous measurements and modulation of the multifaceted signaling at the cellular scale. Extensive efforts have been made to develop multifunctional neural probes, typically involving highly specialized fabrication processes. Here, we report a novel multifunctional neural probe platform realized by applying ultra-thin nanoelectronic coating (NEC) on the surfaces of conventional microscale devices such as optical fibers and micropipettes. We fabricated the NECs by planar photolithography techniques using a substrate-less and multi-layer design, which host arrays of individually addressed electrodes with an overall thickness below 1 µm...
July 6, 2017: Nano Letters
https://www.readbyqxmd.com/read/28648826/attentional-modulation-of-neuronal-activity-depends-on-neuronal-feature-selectivity
#5
Jacqueline R Hembrook-Short, Vanessa L Mock, Farran Briggs
Attention exerts a powerful influence on visual perception. The impact of attention on neuronal activity manifests at early visual information processing stages and progressively increases throughout the visual cortical hierarchy. However, the neuronal mechanisms of attention are unresolved. In particular, the rules governing attentional modulation of individual neurons, whether they are facilitated by or suppressed by attention, are not known. To obtain a more granular or neuron- and circuit-level understanding of the mechanisms of attention and to directly test the feature similarity gain model in V1, we compared attentional modulation with neuronal feature selectivity across a large population of V1 neurons in alert and behaving macaque monkeys trained on an attention-demanding contrast-change detection task...
July 10, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28642471/multi-layered-nioy-nbox-nioy-fast-drift-free-threshold-switch-with-high-ion-ioff-ratio-for-selector-application
#6
Jaehyuk Park, Tobias Hadamek, Agham B Posadas, Euijun Cha, Alexander A Demkov, Hyunsang Hwang
NbO2 has the potential for a variety of electronic applications due to its electrically induced insulator-to-metal transition (IMT) characteristic. In this study, we find that the IMT behavior of NbO2 follows the field-induced nucleation by investigating the delay time dependency at various voltages and temperatures. Based on the investigation, we reveal that the origin of leakage current in NbOx is partly due to insufficient Schottky barrier height originating from interface defects between the electrodes and NbOx layer...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634147/csahi-study-2-validation-of-multi-electrode-array-systems-mea60-2100-for-prediction-of-drug-induced-proarrhythmia-using-human-ips-cell-derived-cardiomyocytes-assessment-of-reference-compounds-and-comparison-with-non-clinical-studies-and-clinical-information
#7
Yumiko Nozaki, Yayoi Honda, Hitoshi Watanabe, Shota Saiki, Kiyotaka Koyabu, Tetsuji Itoh, Chiho Nagasawa, Chiaki Nakamori, Chiaki Nakayama, Hiroshi Iwasaki, Shinobu Suzuki, Kohji Tanaka, Etsushi Takahashi, Kaori Miyamoto, Kaoru Morimura, Atsuhiro Yamanishi, Hiroko Endo, Junko Shinozaki, Hisashi Nogawa, Tadahiro Shinozawa, Fumiyo Saito, Takeshi Kunimatsu
With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period...
June 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28629926/different-functional-susceptibilities-of-mouse-retinal-ganglion-cell-subtypes-to-optic-nerve-crush-injury
#8
Zhen Puyang, Hai-Qing Gong, Shi-Gang He, John B Troy, Xiaorong Liu, Pei-Ji Liang
In optic neuropathies, the progressive deterioration of retinal ganglion cell (RGC) function leads to irreversible vision loss. Increasing experimental evidence suggests differing susceptibility for RGC functional subtypes. Here with multi-electrode array recordings, RGC functional loss was characterized at multiple time points in a mouse model of optic nerve crush. Firing rate, latency of response and receptive field size were analyzed for ON, OFF and ON-OFF RGCs separately. It was observed that responses and receptive fields of OFF cells were impaired earlier than ON cells after the injury...
June 16, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28629075/fabrication-of-chitosan-au-tio2-nanotube-based-dry-electrodes-for-electroencephalography-recording
#9
Yanjuan Song, Penghai Li, Mingji Li, Hongji Li, Cuiping Li, Dazhi Sun, Baohe Yang
In this paper, we describe a method for fabricating dry electrodes for use in recording electroencephalograms (EEGs), which are based on the use of chitosan (Ch), gold (Au) particles, and titanium dioxide (TiO2) nanotube arrays deposited on titanium (Ti) thin sheets. The samples were characterized by scanning electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and EEG signal collection. The TiO2 nanotube arrays were grown on the Ti thin sheet by an electrochemical anodic oxidation method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628030/a-novel-flexible-cuff-like-microelectrode-for-dual-purpose-acute-and-chronic-electrical-interfacing-with-the-mouse-cervical-vagus-nerve
#10
April Shawn Caravaca, Téa Tsaava, Laura Goldman, Harold Silverman, Gary Riggott, Sangeeta Chavan, Chad Bouton, Kevin J Tracey, Robert Desimone, Ed Boyden, Harbaljit Singh Sohal, Peder S Olofsson
OBJECTIVE: Neural reflexes establish homeostasis and regulate the immune system. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus nerve do not permit effective chronic stimulation or recording in mouse models, which is vital to studying the molecular and neurophysiological mechanisms that control inflammation homeostasis in health and disease...
June 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28612758/recording-nerve-signals-in-canine-sciatic-nerves-with-a-flexible-penetrating-microelectrode-array
#11
Donghak Byun, Sung-Joon Cho, Byeong Han Lee, Joongkee Min, Jong-Hyun Lee, Sohee Kim
OBJECTIVE: Previously, we presented the fabrication and characterization of a flexible penetrating microelectrode array (FPMA) as a neural interface device. In the present study, we aim to prove the feasibility of the developed FPMA as a chronic intrafascicular recording tool for peripheral applications. APPROACH: For recording from the peripheral nerves of medium-sized animals, the FPMA was integrated with an interconnection cable and other parts that were designed to fit canine sciatic nerves...
June 14, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28611486/quantitative-measurements-of-dielectrophoresis-in-a-nanoscale-electrode-array-with-an-atomic-force-microscopy
#12
James Froberg, Vidura Jayasooriya, Seungyong You, Dharmakeerthi Nawarathna, Yongki Choi
Nanoelectronic devices integrated with dielectrophoresis (DEP) have been promoted as promising platforms for trapping, separating, and concentrating target biomarkers and cancer cells from a complex medium. Here, we visualized DEP and DEP gradients in conventional nanoelectronic devices by using multi-pass atomic force microcopy techniques. Our measurements directly demonstrated a short range DEP only at sharp step edges of electrodes, frequency dependent DEP polarity, and separation distance dependent DEP strength...
May 15, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28608907/organs-on-chips-with-combined-multi-electrode-array-and-transepithelial-electrical-resistance-measurement-capabilities
#13
Ben M Maoz, Anna Herland, Olivier Y F Henry, William D Leineweber, Moran Yadid, John Doyle, Robert Mannix, Ville J Kujala, Edward A FitzGerald, Kevin Kit Parker, Donald E Ingber
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electrical resistance (TEER) measurements into the chips during their fabrication. To prove proof-of-concept, simultaneous measurements of cellular electrical activity and tissue barrier function were carried out in a dual channel, endothelialized, heart-on-a-chip device containing human cardiomyocytes and a channel-separating porous membrane covered with a primary human endothelial cell monolayer...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28597847/mapping-the-fine-structure-of-cortical-activity-with-different-micro-ecog-electrode-array-geometries
#14
Xi Wang, Alexis Gkogkidis, Olga Iljina, Lukas Fiederer, Chiristian Henle, Irina Mader, Jan Kaminsky, Thomas Stieglitz, Mortimer Gierthmuehlen, Tonio Ball
OBJECTIVE: Innovations in micro-electrocorticography (µECoG) electrode array manufacturing now allow for intricate designs with smaller contact diameters and/or pitch (i.e., center-to-center contact distance) down to the sub-mm range. The aims of the present study were: (i) to investigate whether frequency ranges up to 400 Hz can be reproducibly observed in µECoG recordings and (ii) to examine how differences in topographical substructure between these frequency bands and electrode array geometries can be quantified...
June 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28586910/corneal-potential-maps-measured-with-multi-electrode-electroretinography-in-rat-eyes-with-experimental-lesions
#15
Zahra Derafshi, Brian E Kunzer, Emily M Mugler, Nataliya Rokhmanova, Dong-Wook Park, Hadi Tajalli, Krithi Shetty, Zhenqiang Ma, Justin C Williams, John R Hetling
Purpose: Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small influence on ERG amplitudes compared to normal ranges. Here we evaluate the use of corneal potential maps obtained in response to full-field flash stimuli for sensitivity to local areas of retinal damage...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28582708/new-immobilisation-method-for-oligonucleotides-on-electrodes-enables-highly-sensitive-electrochemical-label-free-gene-sensing
#16
Nihan Aydemir, Eddie Chan, Paul Baek, David Barker, David E Williams, Jadranka Travas-Sejdic
We present a versatile and facile procedure for the immobilisation of bioprobe molecules to an electrochemical sensing element. We eliminate lengthy preparation procedures for direct functionalisation of electrode surfaces by pre-attaching probe molecules to carboxylic acid bearing termonomers of pyrrole phenylenes or thiophene phenylenes. We demonstrate that these conjugates can be electrodeposited at low potentials to form nano-scale porous, electroactive conducting polymer films, exposing the bioprobe and retaining activity and specificity for binding, exemplified here with DNA sensors...
June 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28582456/detailed-spatial-characterization-of-superficial-hip-muscle-activation-during-walking-a-multi-electrode-surface-emg-investigation-of-the-gluteal-region-in-healthy-older-adults
#17
Christoph Anders, Steffen Patenge, Klaus Sander, Frank Layher, Uta Biedermann, Raimund W Kinne
PURPOSE: A multi-electrode array was used to generate spatially resolved Surface electromyography (SEMG) data of the hip muscles in healthy older adults. The cohort was meant to serve as an age-matched, normal control population for future surgical and rehabilitative studies in patients undergoing total hip arthroplasty, in view of the large, continuously increasing number of hip joint replacements. METHODS: Bilateral hip muscle SEMG activity, including tensor fasciae latae (TFL), gluteus medius (Gmed), and gluteus maximus (Gmax), was measured during locomotion on a walkway at self-selected slow, normal, and fast walking speeds (age-matched cohort of 29 females and 25 males)...
2017: PloS One
https://www.readbyqxmd.com/read/28579632/a-multi-functional-microelectrode-array-featuring-59760-electrodes-2048-electrophysiology-channels-stimulation-impedance-measurement-and-neurotransmitter-detection-channels
#18
Jelena Dragas, Vijay Viswam, Amir Shadmani, Yihui Chen, Raziyeh Bounik, Alexander Stettler, Milos Radivojevic, Sydney Geissler, Marie Obien, Jan Müller, Andreas Hierlemann
Biological cells are characterized by highly complex phenomena and processes that are, to a great extent, interdependent. To gain detailed insights, devices designed to study cellular phenomena need to enable tracking and manipulation of multiple cell parameters in parallel; they have to provide high signal quality and high spatiotemporal resolution. To this end, we have developed a CMOS-based microelectrode array system that integrates six measurement and stimulation functions, the largest number to date. Moreover, the system features the largest active electrode array area to date (4...
June 2017: IEEE Journal of Solid-state Circuits
https://www.readbyqxmd.com/read/28574350/characterization-of-kerfless-linear-arrays-based-on-pzt-thick-film
#19
Tomasz Zawada, Louise Bierregaard, Erling Ringgaard, Ruichao Xu, Michele Guizzetti, Franck Levassort, Dominique Certon
Multi-element transducers enabling novel cost-effective fabrication of imaging arrays for medical applications have been presented earlier. Due to the favorable low lateral coupling of the screen-printed PZT, the elements can be defined by the top electrode pattern only, leading to a kerfless design with low cross-talk between the elements. The thick-film based linear arrays have proved to be compatible with a commercial ultrasonic scanner and to support linear array beamforming as well as phased array beamforming...
May 26, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28570546/electrophysiological-analysis-of-human-pluripotent-stem-cell-derived-cardiomyocytes-hpsc-cms-using-multi-electrode-arrays-meas
#20
Luca Sala, Dorien Ward-van Oostwaard, Leon G J Tertoolen, Christine L Mummery, Milena Bellin
Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling cardiovascular diseases in humans, especially arrhythmia syndromes. They have also demonstrated relevance as in vitro systems for predicting drug responses, which makes them potentially useful for drug-screening and discovery, safety pharmacology and perhaps eventually for personalized medicine...
May 12, 2017: Journal of Visualized Experiments: JoVE
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