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IgG4 related arteritis

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https://www.readbyqxmd.com/read/28528047/sclerosing-aortic-and-coronary-arteritis-due-to-igg4-related-disease
#1
Mikael Barbu, Ulf Lindström, Claes Nordborg, Andreas Martinsson, Christian Dworeck, Anders Jeppsson
We present the case of a 55-year-old woman admitted for a coronary artery bypass operation because of three-vessel coronary artery disease based on angiographic findings and clinical symptoms. Unexpected intraoperative findings with diffuse tissue thickening of the ascending aorta and coronary arteries indicated an alternate pathogenesis rather than coronary artery atherosclerosis. Histopathologic findings and clinical evaluation could confirm IgG4-related disease (IgG4-RD). IgG4-RD is a newly recognized fibroinflammatory condition that can present in a variety of organs and is characterized by common histopathologic features...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28503707/the-value-of-ultrasound-in-diagnosing-extracranial-large-vessel-vasculitis-compared-to-fdg-pet-ct-a-retrospective-study
#2
Christian Löffler, Johannes Hoffend, Urs Benck, Bernhard K Krämer, Raoul Bergner
Large-vessel vasculitis (LVV) is a group of diseases mainly comprised of giant-cell arteritis (GCA), Takayasu arteritis, and a series of rare diseases like Behçet's disease, IgG4-related disease, infectious aortitis, and other unfrequent entities. Besides clinical and laboratory features, Doppler sonography (DS) can assist in establishing the diagnosis. Its diagnostic sensitivity has been evaluated in various studies, most of them, however, in temporal arteritis (TA) respectively in LVV with involvement of the temporal artery...
May 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28500877/clinically-isolated-aortitis-pitfalls-progress-and-possibilities
#3
REVIEW
Ilkay Cinar, He Wang, James R Stone
Non-infectious aortitis may be caused by several distinct systemic rheumatologic diseases. In some patients, aortitis is identified either pathologically or radiologically in the absence of clinical evidence of a systemic vasculitis. By consensus nomenclature, such cases are referred to as clinically isolated aortitis (CIA). Some systemic disorders may initially present as CIA including giant cell arteritis (GCA), IgG4-related disease, infectious aortitis, and granulomatosis with polyangiitis. CIA most commonly occurs in women of European descent over the age of 50 and, thus, mirrors the gender, age, and geographic distribution of GCA...
April 23, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28027743/igg4-related-cardiovascular-disease-the-emerging-role-of-cardiovascular-imaging
#4
REVIEW
Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou
Immunoglobulin 4-related disease (IgG4-related disease) is a systemic inflammatory disease that presents with increases of serum IgG4. It may affect various systems, including the cardiovascular (CV) system. Assessment of serum IgG4 levels and involved organ biopsy are necessary for diagnosis. IgG4-related disease is characterized by fibrosclerosis, lymphocytic infiltration and presence of IgG4-positive plasma cells. The disease usually responds to treatment with corticosteroids and/or immunosuppressive medication...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27974093/serum-immunoglobulin-g4-in-giant-cell-arteritis-and-polymyalgia-rheumatica
#5
COMPARATIVE STUDY
Mara Burkel, Fabian Arndt, Jan-Henrik Schirmer, Frank Moosig, Julia U Holle
OBJECTIVES: To date, no specific serum marker for giant cell arteritis and polymyalgia rheumatica has been established in routine practice. Therefore, the aim of this study was to examine whether immunoglobulin G4 serum concentrations could be a potential biomarker for the differentiation of both diseases. METHODS: Serum immunoglobulin G4 (IgG4) concentrations were measured in patients with giant cell arteritis (n=41) and polymyalgia rheumatica (n=27) by an in-house enzyme-linked immunosorbent assay...
March 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27787337/approach-to-cutaneous-vasculitides-with-special-emphasis-on-small-vessel-vasculitis-histopathology-and-direct-immunofluorescence
#6
REVIEW
Cuyan Demirkesen
PURPOSE OF REVIEW: The present review will focus on recent publications in cutaneous vasculitides. RECENT FINDINGS: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27553003/idiopathic-mediastinal-fibrosis-a-systemic-immune-mediated-disorder-a-case-series-and-a-review-of-the-literature
#7
Giovanni M Rossi, Giacomo Emmi, Domenico Corradi, Maria L Urban, Federica Maritati, Federica Landini, Paola Galli, Alessandra Palmisano, Augusto Vaglio
Mediastinal fibrosis is a rare disease characterised by fibrous proliferation in the mediastinum. It can be idiopathic or secondary to several conditions such as infections and malignancies. Anecdotal reports have described idiopathic mediastinal fibrosis (IMF) in association with other fibro-inflammatory or autoimmune diseases. We report nine new IMF cases recently seen at our Fibro-Inflammatory Disease Clinic and reviewed the IMF cases reported in the English language literature throughout 2006-2016. The purposes of our literature search were to assess the frequency of the association between IMF and other immune-mediated disorders and to analyse which disorders most often coexist with IMF...
August 23, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27142374/myocardial-ischemia-as-presenting-manifestation-of-igg4-related-disease-a-case-based-review
#8
REVIEW
Guillermo Delgado-García, Sergio Sánchez-Salazar, Erick Rendón-Ramírez, Mario Castro-Medina, Bárbara Sáenz-Ibarra, Álvaro Barboza-Quintana, María Azalea Loredo-Alanis, David Hernández-Barajas, Dionicio Galarza-Delgado
Coronary involvement in IgG4-related disease (IgG4-RD) has been scarcely reported, and myocardial ischemia as its presenting feature is even rarer. Here, we describe an additional case with novel and relevant observations. The patient was a previously healthy, middle-aged woman who presented to the clinic with new-onset typical angina. One tumefactive lesion encasing the left anterior descending artery was found during her workup. The most common underlying malignancies with secondary cardiac involvement were rationally ruled out...
November 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27115208/laboratory-investigations-for-diagnosis-of-autoimmune-and-inflammatory-periocular-disease-part-ii
#9
REVIEW
Archana Srinivasan, Teri T Kleinberg, Ann P Murchison, Jurij R Bilyk
PURPOSE: To review the important laboratory serological investigations routinely performed for the diagnosis of autoimmune and inflammatory diseases of the orbit and ocular adnexa. METHODS: Review of the literature as well as personal clinical experience of the authors. Due to the extensive nature of the topic, the review has been split into 2 parts. Part I covers thyroid eye disease, IgG4-related disease, and myasthenia gravis. In part II of the review, sarcoidosis, vasculitis, Sjögren syndrome, and giant cell arteritis will be discussed...
January 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27097062/laboratory-investigations-for-diagnosis-of-autoimmune-and-inflammatory-periocular-disease-part-i
#10
REVIEW
Archana Srinivasan, Teri T Kleinberg, Ann P Murchison, Jurij R Bilyk
PURPOSE: To review the important laboratory serological investigations routinely performed for the diagnosis of autoimmune and inflammatory diseases of the orbit and ocular adnexa. METHODS: Review of the literature as well as personal clinical experience of the authors. RESULTS: Periocular inflammation is a blanket term which refers to a wide variety of conditions affecting the orbit and the ocular adnexa. Although the etiology of each of these conditions is different, their similarity lies in their clinical presentation and in the fact that each of them can be vision-threatening and even life-threatening if left untreated...
September 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26986706/inflammatory-diseases-of-the-aorta
#11
REVIEW
Ludwig Caspary
Inflammatory aortic diseases may occur with and without dilatation and are complicated by obstruction, rupture and dissection. Infections originate from periaortic foci or septicaemia and tend to result in the rapid development of aneurysms. Large vessel vasculitis due to Takayasu arteritis in younger and giant cell arteritis (GCA) in older patients is located in all layers of the aortic wall and prevails in the thoracic section. GCA patients are prone to developing aortic complications in the late course of disease...
January 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/26975015/fdg-pet-ct-in-igg4-related-peripulmonary-arteritis
#12
Aisheng Dong, Yang Wang, Changjing Zuo
IgG4-related peripulmonary arteritis is rare. A 60-year-old woman presented with fatigue for more than 2 years. Transthoracic echocardiography revealed a lesion measuring 2.1 × 1.5 cm in the pulmonary artery bifurcation. CT pulmonary angiography showed marked stenosis of the right and left pulmonary arteries. FDG PET/CT showed increased FDG uptake of the thickened walls in the bilateral pulmonary arteries with SUVmax of 5.8. The patient underwent partial resection of the pulmonary artery lesion. IgG4-related peripulmonary arteritis was confirmed by pathology...
October 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/26948271/-differential-diagnosis-of-aortitis
#13
REVIEW
C Rousselin, F Pontana, P Puech, M Lambert
Aortitis are mainly described in inflammatory disorders such as Takayasu arteritis, giant cell arteritis or Behçet's disease. Aortitis is sometimes qualified as idiopathic. However, differential diagnoses must be searched since they need specific interventions. Infectious aortitis should be ruled out first as its rapid evolution and short-term poor prognosis makes it a therapeutic emergency. Furthermore, rarer differential diagnoses should be known as they require specific care that might sometimes differ from the treatment of inflammatory aortitis, such as retroperitoneal fibrosis mostly idiopathic but also secondary to neoplasia or malignant hemopathies...
April 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26919999/igg4-related-disease-with-coronary-arteritis
#14
Abhishek R Keraliya, David J Murphy, Ayaz Aghayev, Michael L Steigner
No abstract text is available yet for this article.
March 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/26603648/igg4-related-disease-with-coronary-arteritis
#15
Jian Yang, Zhixing Fan, Jun Yang, Chaojun Yang
No abstract text is available yet for this article.
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26401675/igg4-related-plasma-cell-granuloma-of-the-maxillary-sinus-a-report-of-2-cases
#16
Masaru Kojima, Yoshimasa Nakazato, Kaoru Hirabayashi, Nobuhide Masawa, Naoya Nakamura
We report 2 rare cases of IgG4-related plasma cell granuloma of the maxillary sinus. Histologically, both lesions were characterized by severe lymphoplasmacytic infiltration. In 1 case, fibrous sclerosis and obliterative arteritis were observed. Immunohistochemical study demonstrated that IgG4-positive cells comprised more than 40% of the IgG-positive plasma cells. Moreover, the serum IgG4 level was elevated in both cases. A good responsiveness to steroid therapy has been seen in IgG4-related disease. From a therapeutic perspective, it is important to recognize IgG4-related plasma cell granuloma...
September 2015: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/26341570/igg4-related-kidney-disease-a-review
#17
REVIEW
Dinesh Pradhan, Niharika Pattnaik, Russell Silowash, Sambit Kumar Mohanty
IgG4-related disease (IgG4-RD) is a recently recognized systemic autoimmune disorder characterized by high levels of serum IgG4 and dense infiltration of IgG4-positive plasma cells in multiple organs. The condition was first described as a disease of the pancreas, and has since been recognized in various organ systems including the kidneys. IgG4 related kidney disease (IgG4-RKD) signifies any form of renal involvement by IgG4-RD. The most common renal involvement by IgG4-RD is tubulointerstitial nephritis. Glomerular disease, in particular membranous glomerulonephritis, may also be seen...
October 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26288265/spectrum-of-igg4-related-disease-on-multi-detector-ct-a-5-year-study-of-a-single-medical-center-data
#18
Yonglan He, Xuechao Du, Ning Ding, Zhuo Li, Weixun Zhou, Bo Chen, Zhengyu Jin, Hao Sun, Liang Zhu, Huadan Xue
PURPOSE: To discuss the diverse imaging features of pancreatic and extra-pancreatic lesions of IgG4-related disease (IgG4-RD) on multi-detector CT (MDCT). METHODS: This retrospective study was approved by our institutional research ethics board, and informed consent was waived. From 2008 to 2013, 159 patients including 120 men (mean age 57 years; range 27-79 years) and 39 women (mean age 51 years; range 25-83 years) who met the comprehensive diagnostic criteria for IgG4-RD (2011) were enrolled...
October 2015: Abdominal Imaging
https://www.readbyqxmd.com/read/26166493/immune-complexome-analysis-of-antigens-in-circulating-immune-complexes-isolated-from-patients-with-igg4-related-dacryoadenitis-and-or-sialadenitis
#19
Kaname Ohyama, Miyako Baba, Mami Tamai, Motohisa Yamamoto, Kunihiro Ichinose, Naoya Kishikawa, Hiroki Takahashi, Atsushi Kawakami, Naotaka Kuroda
OBJECTIVES: IgG4-related disease (IgG4-RD) is characterized by various serological abnormalities. Some patients with IgG4-RD present with hypergammaglobulinemia, hypocomplementemia, and autoantibodies recognizing rheumatoid factors and nuclear factors. However, whether IgG4-RD is an autoimmune disease remains unclear. METHODS: Here, we used immune complexome analysis to comprehensively identify constituent antigens of circulating immune complexes isolated from 10 patients with IgG4-related dacryoadenitis and/or sialadenitis (IgG4-RDS) which is one condition associated with IgG4-RD...
2016: Modern Rheumatology
https://www.readbyqxmd.com/read/26160265/crdc-a-chinese-rheumatology-research-platform
#20
REVIEW
Mengtao Li, Xinping Tian, Wen Zhang, Xiaomei Leng, Xiaofeng Zeng
This review introduces the history of development, organizational structure, funding resources, data collection, and quality control of the Chinese Rheumatism Data Center (CRDC) and summarizes the collection of data. In 2009, Peking Union Medical College Hospital (PUMCH), together with several rheumatism centers, established the Chinese Systemic Lupus Erythematosus (SLE) Treatment and Research Group (CSTAR) to collect data on Chinese patients for the study of SLE disease characteristics. In 2011, CSTAR was extended with the formation of the CRDC at PUMCH with direction from the National Health and Family Planning Commission of the PRC...
August 2015: Clinical Rheumatology
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