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https://www.readbyqxmd.com/read/28025728/semiautomatic-classification-of-acetabular-shape-from-three-dimensional-ultrasound-for-diagnosis-of-infant-hip-dysplasia-using-geometric-features
#1
Abhilash Rakkunedeth Hareendranathan, Dornoosh Zonoobi, Myles Mabee, Chad Diederichs, Kumaradevan Punithakumar, Michelle Noga, Jacob L Jaremko
PURPOSE: Developmental dysplasia of the hip (DDH) is a congenital deformity which in severe cases leads to hip dislocation and in milder cases to premature osteoarthritis. Image-aided diagnosis of DDH is partly based on Graf classification which quantifies the acetabular shape seen at two-dimensional ultrasound (2DUS), which leads to high inter-scan variance. 3D ultrasound (3DUS) is a promising alternative for more reliable DDH diagnosis. However, manual quantification of acetabular shape from 3DUS is cumbersome...
December 26, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27990423/size-does-not-make-the-difference-3d-4d-transperineal-sonographic-measurements-of-the-female-urethra-in-the-assessment-of-urinary-incontinence-subtypes
#2
Tomas Kupec, Ulrich Pecks, Charlotte M Gräf, Elmar Stickeler, Ivo Meinhold-Heerlein, Laila Najjari
Purpose. The objective was to evaluate the usefulness of transperineal ultrasound in the assessment of the urethral length and urethral lumen by 3D/4D transperineal sonography to discriminate between female patients with subtypes of urinary incontinence. Methods. A total of 150 female patients underwent an examination because of urinary incontinence. 41 patients were diagnosed with urgency urinary incontinence (OAB), 67 patients were diagnosed with stress urinary incontinence (SUI), and 42 patients were in the control group (CTRL)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27958731/the-cushion-method-a-new-technique-for-the-recovery-of-hydrophilic-nanocarriers
#3
Wei He, Robert Graf, Stefan Vieth, Ulrich Ziener, Katharina Landfester, Daniel Crespy
Microencapsulation of hydrophilic therapeutic agents such as proteins or nucleotides into a nanocarrier is frequently accomplished in inverse (water-in-oil) emulsions. However, the redispersion of the nanocarriers in aqueous media often involves a complicated purification process, and the redispersion usually requires additional surfactants for its colloidal stability, which is not favored for biological applications. We propose a simple, fast, and mild method to recover hydrophilic nanocarriers prepared in inverse emulsions by temporary coating of the nanocarriers with biocompatible small molecules, so that the final aqueous dispersion of the nanocarriers can be dispersed with high recovery rate, minimal aggregation, and no additional surfactants...
December 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27951600/multimodal-and-sequential-treatment-improves-survival-in%C3%A2-patients-with-hepatocellular-carcinoma
#4
Thomas Göbel, Dirk Graf, Christina Hosnowsky, Dirk Blondin, Wolfram Trudo Knoefel, Dieter Häussinger, Andreas Erhardt
Background and aims Therapy of hepatocellular carcinoma (HCC) mainly depends on tumor stage and liver function. The aim of this study was to identify additional predictors of overall survival in HCC patients with a particular attention to multimodal therapies. Methods Six hundred and seven consecutive HCC-patients treated in a tertiary center between 1988 and 2011 were retrospectively analyzed. Multivariate analysis was performed by logistic and Cox-regression, overall survival was analyzed by Kaplan Meier statistics...
December 12, 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27931353/game-changing-innovation-in-chemical-production-methods-concepts-examples
#5
Xenia Beyrich-Graf
No abstract text is available yet for this article.
September 2016: Chimia
https://www.readbyqxmd.com/read/27919386/donor-s-support-tool-enabling-informed-secondary-use-of-patient-s-biomaterial-and-personal-data
#6
Haridimos Kondylakis, Lefteris Koumakis, Stephanie Hänold, Iheanyi Nwankwo, Nikolaus Forgó, Kostas Marias, Manolis Tsiknakis, Norbert Graf
PURPOSE: Biomedical research is being catalyzed by the vast amount of data rapidly collected through the application of information technologies (IT). Despite IT advances, the methods for involving patients and citizens in biomedical research remain static, paper-based and organized around national boundaries and anachronistic legal frameworks. The purpose of this paper is to study the current practices for obtaining consent for biobanking and the legal requirements for reusing the available biomaterial and data in EU and finally to present a novel tool to this direction enabling the secondary use of data and biomaterial...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27784123/-cost-effectiveness-of-pharmacological-smoking-cessation-therapies-a-systematic-literature-review
#7
I Aumann, K Rozanski, K Damm, J-M Graf von der Schulenburg
Aim of the Study: Through the promotion of smoking cessation premature mortality can be prevented. Therefore it is necessary to provide effective and cost-effective smoking cessation interventions. In Germany the cost of pharmacological smoking cessation measures are not yet reimbursed by the statutory health insurance. The aim of this study is to present the evidence on the cost-effectiveness of already approved pharmacological smoking cessation therapies and to evaluate their quality. Method: A systematic literature research was conducted in the databases by DIMDI (Medline, Embase, etc...
October 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27761027/health-related-quality-of-life-in-metastatic-and-adjuvant-breast-cancer-patients
#8
M Wallwiener, E Simoes, A N Sokolov, S Y Brucker, P A Fasching, J Graf
Introduction: When cancer patients have advanced disease and a primary cure is no longer possible, the focus is on maintaining the patient's quality of life. Recent therapeutic advances in breast cancer treatment mean that even patients with metastatic disease can remain stable for long periods of time. The aim of this study was to look at the health-related quality of life (HRQL) of these patients and compare it with data for the general population and to show the differences in outcomes for different survey instruments used to measure quality of life...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27736695/habitat-use-and-tolerance-levels-of-macroinvertebrates-concerning-hydraulic-stress-in-hydropeaking-rivers-a-case-study-at-the-ziller-river-in-austria
#9
P Leitner, C Hauer, W Graf
Artificial flow fluctuations due to the operation of hydropower plants, frequently described as hydropeaking, result in a constant decrease of biomass of specific macrozoobenthos (MZB) taxa. For the presented case study, we assessed three reaches in the Ziller River catchment. At each sampling reach we performed the Multi-Habitat-Sampling (MHS) method with a Water Framework Directive (WFD) compliant AQEM/MHS net according to the Austrian guideline. Additionally, a hydraulic-specific sampling was conducted with a modified Box (Surber) sampler...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27723282/rheumatoid-arthritis-na%C3%A3-ve-t-cells-share-hypermethylation-sites-with-synoviocytes
#10
Brooke Rhead, Calliope Holingue, Michael Cole, Xiaorong Shao, Hong L Quach, Diana Quach, Khooshbu Shah, Elizabeth Sinclair, John Graf, Thomas Link, Ruby Harrison, Elior Rahmani, Eran Halperin, Wei Wang, Gary S Firestein, Lisa F Barcellos, Lindsey A Criswell
Objectives Our study aimed to determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) patients were also differentially methylated in peripheral blood samples. Methods We measured 371 genome-wide DNA methylation profiles from 63 RA cases and 31 controls, in CD14+ monocytes, CD19+ B cells, CD4+ memory T cells and CD4+ naïve T cells, using Illumina HumanMethylation450 (450k) BeadChips. Results We found that of 5,532 hypermethylated FLS candidate CpGs, 1,056 were hypermethylated in CD4+ naïve T cells of RA cases compared to controls...
October 9, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27716184/amino-acid-pet-versus-mri-guided-re-irradiation-in-patients-with-recurrent-glioblastoma-multiforme-gliaa-protocol-of-a-randomized-phase-ii-trial-noa-10-aro-2013-1
#11
Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G Baumert, Susan C Short, Philipp T Meyer, Wolfgang A Weber, Anca-Ligia Grosu
BACKGROUND: The higher specificity of amino-acid positron emission tomography (AA-PET) in the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment-related alterations, in comparison to contrast enhancement in T1-weighted MRI was demonstrated in many studies and is the rationale for their implementation into radiation oncology treatment planning. Several clinical trials have demonstrated the significant differences between AA-PET and standard MRI concerning the definition of the gross tumor volume (GTV)...
October 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27698744/clinical-evaluation-of-ultrasound-screening-in-follow-up-visits-of-infants-with-cerebral-palsy-at-high-risk-for-developmental-dysplasia-of-the-hip
#12
Aizhen Qiu, Zhongxiu Yang, Jiping Wang, Taotao Wang
The aim of the study was to assess the clinical value of ultrasound screenings for the developmental dysplasia of the hip (DDH) and explore its etiology in high-risk infants with cerebral palsy in follow-up visits. A group of 98 cases of infants at high-risk of cerebral palsy who received rehabilitation treatment between July, 2009 and July, 2010 were selected. Infants included 58 men and 40 women, aged <6 months and not lost to follow-up visits. Ultrasound (using Graf static inspection) screening of hips was performed and the infants with abnormalities were given clinical intervention, and 1- to 2-year-old infants were given outpatient follow-ups...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27688927/a-novel-method-for-morphological-pleomorphism-and-heterogeneity-quantitative-measurement-named-cell-feature-level-co-occurrence-matrix
#13
Akira Saito, Yasushi Numata, Takuya Hamada, Tomoyoshi Horisawa, Eric Cosatto, Hans-Peter Graf, Masahiko Kuroda, Yoichiro Yamamoto
BACKGROUND: Recent developments in molecular pathology and genetic/epigenetic analysis of cancer tissue have resulted in a marked increase in objective and measurable data. In comparison, the traditional morphological analysis approach to pathology diagnosis, which can connect these molecular data and clinical diagnosis, is still mostly subjective. Even though the advent and popularization of digital pathology has provided a boost to computer-aided diagnosis, some important pathological concepts still remain largely non-quantitative and their associated data measurements depend on the pathologist's sense and experience...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27662383/graf-type-iv-hips-have-a-higher-risk-of-residual-acetabular-dysplasia-at-1-year-of-age-following-successful-pavlik-harness-treatment-for-developmental-hip-dysplasia
#14
Eduardo N Novais, Julia Sanders, Lauryn A Kestel, Patrick M Carry, Mariana L Meyers
BACKGROUND: We asked whether patient-specific factors and ultrasound (US) measurements of hip dysplasia severity at initial examination influence short-term residual acetabular dysplasia in patients successfully treated with Pavlik harness for developmental hip dysplasia. METHODS: After IRB approval, 134 hips (84 patients) successfully treated by the Pavlik method between August 2011 and October 2014 with follow-up at 12 months of age were identified. Early successful treatment was defined as normal examination and US after approximately 12 weeks of Pavlik treatment...
September 22, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27646538/game-changing-innovation-in-chemical-production-methods-concepts-examples
#15
Xenia Beyrich-Graf
No abstract text is available yet for this article.
September 2016: Chimia
https://www.readbyqxmd.com/read/27634475/free-energy-calculations-of-residue-mutations-in-a-tripeptide-using-various-methods-to-overcome-inefficient-sampling
#16
Michael M H Graf, Manuela Maurer, Chris Oostenbrink
Previous free-energy calculations have shown that the seemingly simple transformation of the tripeptide KXK to KGK in water holds some unobvious challenges concerning the convergence of the forward and backward thermodynamic integration processes (i.e., hysteresis). In the current study, the central residue X was either alanine, serine, glutamic acid, lysine, phenylalanine, or tyrosine. Interestingly, the transformation from alanine to glycine yielded the highest hysteresis in relation to the extent of the chemical change of the side chain...
November 5, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27617677/exploring-quantitative-yeast-phenomics-with-single-cell-analysis-of-dna-damage-foci
#17
Erin B Styles, Karen J Founk, Lee A Zamparo, Tina L Sing, Dogus Altintas, Cyril Ribeyre, Virginie Ribaud, Jacques Rougemont, David Mayhew, Michael Costanzo, Matej Usaj, Adrian J Verster, Elizabeth N Koch, Daniele Novarina, Marco Graf, Brian Luke, Marco Muzi-Falconi, Chad L Myers, Robi David Mitra, David Shore, Grant W Brown, Zhaolei Zhang, Charles Boone, Brenda J Andrews
A significant challenge of functional genomics is to develop methods for genome-scale acquisition and analysis of cell biological data. Here, we present an integrated method that combines genome-wide genetic perturbation of Saccharomyces cerevisiae with high-content screening to facilitate the genetic description of sub-cellular structures and compartment morphology. As proof of principle, we used a Rad52-GFP marker to examine DNA damage foci in ∼20 million single cells from ∼5,000 different mutant backgrounds in the context of selected genetic or chemical perturbations...
September 7, 2016: Cell Systems
https://www.readbyqxmd.com/read/27613239/comparison-of-different-approaches-applied-in-analytic-hierarchy-process-an-example-of-information-needs-of-patients-with-rare-diseases
#18
Frédéric Pauer, Katharina Schmidt, Ana Babac, Kathrin Damm, Martin Frank, J-Matthias Graf von der Schulenburg
BACKGROUND: The Analytic Hierarchy Process (AHP) is increasingly used to measure patient priorities. Studies have shown that there are several different approaches to data acquisition and data aggregation. The aim of this study was to measure the information needs of patients having a rare disease and to analyze the effects of these different AHP approaches. The ranking of information needs is then used to display information categories on a web-based information portal about rare diseases according to the patient's priorities...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27612843/titanium-dental-implant-surfaces-obtained-by-anodic-spark-deposition-from-the-past-to-the-future
#19
REVIEW
Milena R Kaluđerović, Joachim P Schreckenbach, Hans-Ludwig Graf
Commercial titanium-based dental implants are obtained applying various methods such as machining, acid etching, anodization, plasma spraying, grit blasting or combination techniques yielding materials with smooth or micro-roughened surfaces. Those techniques are used to optimize the surface properties and to maximize biocompatibility and bioactivity with bone tissue. Present review is focused on the material surfaces obtained by anodic spark deposition (ASD). From the early 1980s till present, the results of numerous studies have shown that anodically oxidized surfaces with different dopants express a positive effect on osteoblasts behavior in vitro and osseointegration in vivo...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27610378/tomographic-ultrasound-imaging-to-control-the-placement-of-tension-free-transobturator-tape-in-female-urinary-stress-incontinence
#20
Charlotte M Gräf, Tomas Kupec, Elmar Stickeler, Tamme W Goecke, Ivo Meinhold-Heerlein, Laila Najjari
Purpose. The objective was to evaluate, by means of tomographic ultrasound imaging (TUI), the reliability of a novel approach for determining the position of the implanted tension-free transobturator tape (TOT). Furthermore, we analyzed the association between the position of the tape at rest and the subjective cure in stress incontinent women. Methods. This retrospective pilot study consists of 32 stress incontinent women, who underwent TOT procedure and routine sonographic control at day 1 postoperatively and at follow-up visit...
2016: BioMed Research International
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