keyword
MENU ▼
Read by QxMD icon Read
search

Graf method

keyword
https://www.readbyqxmd.com/read/29672680/cognitive-correlates-of-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-in-mild-alzheimer-s-dementia
#1
Osama Sabri, Philipp M Meyer, Susanne Gräf, Swen Hesse, Stephan Wilke, Georg-Alexander Becker, Michael Rullmann, Marianne Patt, Julia Luthardt, Gudrun Wagenknecht, Alexander Hoepping, Rene Smits, Annegret Franke, Bernhard Sattler, Solveig Tiepolt, Steffen Fischer, Winnie Deuther-Conrad, Ulrich Hegerl, Henryk Barthel, Peter Schönknecht, Peter Brust
In early Alzheimer's dementia, there is a need for PET biomarkers of disease progression with close associations to cognitive dysfunction that may aid to predict further cognitive decline and neurodegeneration. Amyloid biomarkers are not suitable for that purpose. The α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) are widely abundant in the human brain. As neuromodulators they play an important role in cognitive functions such as attention, learning and memory. Post-mortem studies reported lower expression of α4β2-nAChRs in more advanced Alzheimer's dementia...
April 17, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29663083/-self-hypnosis-training-for-in-hospital-chronic-pain-patients-a-retrolective-observational-study
#2
Peter C Keil, Nicole Lindenberg, Christoph L Lassen, Bernhard M Graf, Jens Meier, Christoph H Wiese
BACKGROUND: Hypnosis is probably one of the oldest therapies known to man. In the last decades modern hypnosis has mainly been used by psychotherapists; however, hypnosis is becoming increasingly more important as a therapeutic method in medicine. Hypnosis can be used for a variety of medical indications. In the literature there is much evidence for the effectiveness of hypnosis. The aim of the present investigation was to demonstrate the effectiveness of hypnosis in inpatient treatment of chronic pain patients and to present a self-hypnosis program, which can be easily integrated into pain therapy...
April 16, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29658715/accurate-and-efficient-parallel-implementation-of-an-effective-linear-scaling-direct-random-phase-approximation-method
#3
Daniel Graf, Matthias Beuerle, Henry F Schurkus, Arne Luenser, Gökcen Savasci, Christian Ochsenfeld
An efficient algorithm for calculating the random phase approximation (RPA) correlation energy is presented that is as accurate as the canonical molecular orbital resolution-of-the-identity RPA (RI-RPA) with the important advantage of an effective linear-scaling behavior (instead of quartic) for large systems due to a formulation in the local atomic orbital space. The high accuracy is achieved by utilizing optimized minimax integration schemes and the local Coulomb metric attenuated by the complementary error function for the RI approximation...
April 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29623540/patient-specific-catheter-shaping-for-the-minimally-invasive-closure-of-the-left-atrial-appendage
#4
Eva C Graf, Ilka Ott, Julian Praceus, Felix Bourier, Tim C Lueth
PURPOSE: The minimally invasive closure of the left atrial appendage is a promising alternative to anticoagulation for stroke prevention in patients suffering from atrial fibrillation. One of the challenges of this procedure is the correct positioning and the coaxial alignment of the tip of the catheter sheath to the implant landing zone. METHOD: In this paper, a novel preoperative planning system is proposed that allows patient-individual shaping of catheters to facilitate the correct positioning of the catheter sheath by offering a patient-specific catheter shape...
April 5, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29616553/orthogonal-tip-to-tip-nanocapillary-alignment-allows-for-easy-detection-of-fluorescent-emitters-in-femtomolar-concentrations
#5
Po-Ling Chang, Michael Graf, Chao-Hsuan Hung, Aleksandra Radenovic
Here we present the realization of a novel fluorescence detection method based on the electromigration of fluorescent molecules within a nanocapillary combined with the laser excitation through a platinum (Pt)-coated nanocapillary. By using the Pt-nanocapillary assisted focusing of a laser beam we completely remove the background scattering on the tip of the electrophoretic nanocapillary. In this excitation geometry we demonstrate a thousandfold sensitivity enhancement (1.0 nM to 1.0 pM) compared to the detection in microcapillaries with epifluorescence illumination and fluorescence spectrophotometry...
April 4, 2018: Nano Letters
https://www.readbyqxmd.com/read/29611343/work-disability-in-argentinian-patients-with-systemic-lupus-erythematosus-is-prevalent-and-it-is-due-to-ethnic-socioeconomic-and-disease-related-factors
#6
Cecilia N Pisoni, Sebastián A Muñoz, María N Tamborenea, Mercedes García, Ana Curti, Ana Cappuccio, Oscar Rillo, Patricia M Imamura, Emilce Schneeberger, Marcela Ballent, Mario L Cousseau, Jorge Velasco Zamora, Verónica Saurit, Sergio Toloza, María C Danielsen, Verónica I Bellomio, Cesar Graf, Sergio Paira, Javier Cavallasca, Bernardo Pons Estel, José L C Moreno, Mónica Díaz, Paula Alba, Marcela Verando, Guillermo Tate, Eduardo Mysler, Judith Sarano, Emma E Civit, Fabián Risueño, Pablo Álvarez Sepúlveda, María S Larroude, Marcos F Méndez, Andrea Conforti, Débora Sohn
OBJECTIVE: To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients. METHODS: A sample of 419 SLE patients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE...
April 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29601872/spatiotemporal-and-demographic-history-of-the-hiv-1-circulating-recombinant-form-crf31_bc-in-brazil
#7
Hegger M Fritsch, Sabrina E M Almeida, Aguinaldo R Pinto, Tiago Gräf
CRF31_BC is an HIVs-1 recombinant form very prevalent in the southernmost capital city of Brazil, Porto Alegre. Recent studies have been describing a growing number of cases of infection by CRF31_BC in other Brazilian cities and countries, suggesting a process of expansion of this strain. Aiming to describe the city of origin, dispersion routes and demographic history of CRF31_BC, this study analyzed all HIV-1 CRF31_BC and Brazilian BC mosaic publicly available sequences. CRF31_BC classification was performed by bootscanning and tree reconstruction methods...
March 27, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29580377/chemsex-among-men-who-have-sex-with-men-in-germany-motives-consequences-and-the-response-of-the-support-system
#8
Niels Graf, Anna Dichtl, Daniel Deimel, Dirk Sander, Heino Stöver
Background: In Germany, drug use in sexual settings (i.e. chemsex) among men who have sex with men (MSM) has increasingly been the subject of discussion for considerable time. At the same time, however, little is known about this practice. It is against this background that what is currently known about chemsex among MSM in Germany is discussed. Methods: The present study observations are essentially based on the results of two research projects of a qualitative-explorative nature. In-depth interviews with drug-using MSM (n=14), as well as qualitative, problem-centred interviews with drug-using MSM (n=75) and expert interviews (n=27) were conducted within these research projects...
March 27, 2018: Sexual Health
https://www.readbyqxmd.com/read/29574164/phylodynamic-analysis-and-molecular-diversity-of-the-avian-infectious-bronchitis-virus-of-chickens-in-brazil
#9
Aline Padilha de Fraga, Tiago Gräf, Cleiton Schneider Pereira, Nilo Ikuta, André Salvador Kazantzi Fonseca, Vagner Ricardo Lunge
Avian infectious bronchitis virus (IBV) is the etiological agent of a highly contagious disease, which results in severe economic losses to the poultry industry. The spike protein (S1 subunit) is responsible for the molecular diversity of the virus and many sero/genotypes are described around the world. Recently a new standardized classification of the IBV molecular diversity was conducted, based on phylogenetic analysis of the S1 gene sequences sampled worldwide. Brazil is one of the biggest poultry producers in the world and the present study aimed to review the molecular diversity and reconstruct the evolutionary history of IBV in the country...
March 21, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29565717/determinants-of-pediatric-ems-utilization-in-children-with-high-acuity-conditions
#10
Casandra Quiñones, Manish I Shah, Andrea T Cruz, Jeanine M Graf, Juan A Mondragon, Elizabeth A Camp, Pooja Reddy, Esther M Sampayo
BACKGROUND: Underutilization of emergency medical services (EMS) for children with high-acuity conditions is poorly understood. Our objective was to identify differences in demographic factors and describe caregivers' knowledge, beliefs, and attitudes regarding EMS utilization for children with high-acuity conditions. DESIGN/METHODS: This was a mixed-methods study of children with high acuity conditions, defined as requiring immediate medical or surgical intervention and intensive care admission, over a one year period...
March 22, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29524009/reproducibility-of-acquiring-ultrasonographic-infant-hip-images-by-the-graf-method-after-an-infant-hip-ultrasound-training-course
#11
Yasuhiro Shirai, Kenjiro Wakabayashi, Ikuo Wada, Hideyuki Goto, Yoshino Ueki, Atsushi Tsuchiya, Yoshiaki Tsuboi, Myongsu Ha, Takanobu Otsuka
PURPOSE: The objective screening of infant hips using ultrasonography (Graf method) is gaining favor in the diagnosis of developmental dysplasia of the hip in Japan. However, the accuracy of the Graf method is dependent on the examiner's experience and technique. The purpose of this study was to investigate the reproducibility of acquiring ultrasonic hip images and their evaluation after examiners attended an infant hip ultrasound training course. MATERIALS AND METHODS: Ultrasonic images of 70 hips of 35 newborns who were screened by ultrasonography using the Graf method, were evaluated...
March 9, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29509577/optimizing-the-time-for-developmental-dysplasia-of-the-hip-screening-earlier-or-later
#12
Fatma Dilek Gokharman, Sonay Aydin, Erdem Fatihoglu, Elif Ergun, Pinar Nercis Kosar
INTRODUCTION: Developmental dysplasia of the hip (DDH) is still a common and important disorder of childhood, with a prevalence of 0.1 to 2/1000 children. Using ultrasonography (US) in screening of DDH reduces the rates of open reductions and complications. In the current study, we aim to detect the optimal time for US examination for detecting DDH to prevent unnecessary repeating US examinations and treatments. METHODS: Children referred to US examination for a healthy child screening program, according to the health policy of our country, are included in the current prospective study...
March 5, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29486499/-practicability-and-efficiency-of-e-health-applications-in-patient-reported-outcomes-state-of-and-need-for-research
#13
Joachim Graf, Beatrice Moreno, Markus Wallwiener, Karina Menzel, Sara Y Brucker, Elisabeth Simoes
AIMS: E-health-based technologies also play an increasing role in the collection of patient- reported outcomes (ePRO). However, it remains unclear how feasible and powerful e-health applications are in the collection of PRO. Therefore, it should be examined to what extent the requirements for the use of technology-based PRO instruments has already been explored in order to allow its broad use in the "e-health world". Specifically, the research focus is on practicability, capability and technical implementation of ePRO...
February 27, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29480318/-outpatient-palliative-medicine-attitudes-in-the-care-of-palliative-emergencies-prospective-questionnaire-based-investigation
#14
REVIEW
C H R Wiese, V M C Silbereisen, B M Graf, A C Bundscherer, C L Lassen
BACKGROUND: The right to adequate outpatient palliative care has existed for several years in Germany. In recent years outpatient palliative care has developed very positively. Nevertheless, in emergency situations paramedics and emergency physicians were often included in the care of palliative care of patients. The aim of our study was to investigate the cooperation between outpatient palliative care teams and the emergency medical services. Another aim was to identify structural realities and based on these to discuss the possibilities in the optimization of outpatient palliative medical emergency situations...
February 26, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29415838/methods-to-validate-the-accuracy-of-an-indirect-calorimeter-in-the-in-vitro-setting
#15
Taku Oshima, Marco Ragusa, Séverine Graf, Yves Marc Dupertuis, Claudia-Paula Heidegger, Claude Pichard
INTRODUCTION: The international ICALIC initiative aims at developing a new indirect calorimeter according to the needs of the clinicians and researchers in the field of clinical nutrition and metabolism. The project initially focuses on validating the calorimeter for use in mechanically ventilated acutely ill adult patient. However, standard methods to validate the accuracy of calorimeters have not yet been established. This paper describes the procedures for the in-vitro tests to validate the accuracy of the new indirect calorimeter, and defines the ranges for the parameters to be evaluated in each test to optimize the validation for clinical and research calorimetry measurements...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29410800/deletion-loss-of-bone-morphogenetic-protein-7-changes-tooth-morphology-and-function-in-mus-musculus-implications-for-dental-evolution-in-mammals
#16
Chelsey Zurowski, Heather Jamniczky, Daniel Graf, Jessica Theodor
Quantifying regulatory gene effects on dental morphology and function has implications for the underlying mechanisms that generated dental diversity in mammals. We tested the hypothesis that regulatory gene expression changes lead to differences in molars using a neural crest knockout of bone morphogenetic protein 7 (BMP7) in Mus musculus. Three-dimensional geometric morphometric methods were used to quantify the shape of the molar toothrow. BMP7 mutants have extra cusps on the first upper and lower molars, and alterations in cusp orientation and morphology...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29394371/oned-increasing-reproducibility-of-hi-c-samples-with-abnormal-karyotypes
#17
Enrique Vidal, François le Dily, Javier Quilez, Ralph Stadhouders, Yasmina Cuartero, Thomas Graf, Marc A Marti-Renom, Miguel Beato, Guillaume J Filion
The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, Hi-C is subject to systematic biases that can compromise downstream analyses. Several strategies have been proposed to remove those biases, but the issue of abnormal karyotypes received little attention. Many experiments are performed in cancer cell lines, which typically harbor large-scale copy number variations that create visible defects on the raw Hi-C maps...
January 31, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29324759/disease-burden-of-methylmercury-in-the-german-birth-cohort-2014
#18
Julia Lackner, Michael Weiss, Christine Müller-Graf, Matthias Greiner
This study aimed to estimate the disease burden of methylmercury for children born in Germany in the year 2014. Humans are mainly exposed to methylmercury when they eat fish or seafood. Prenatal methylmercury exposure is associated with IQ loss. To quantify this disease burden, we used Monte Carlo simulation to estimate the incidence of mild and severe mental retardation in children born to mothers who consume fish based on empirical data. Subsequently, we calculated the disease burden with the disability-adjusted life years (DALY)-method...
2018: PloS One
https://www.readbyqxmd.com/read/29216670/-systematic-review-of-the-burden-of-campylobacter-associated-disease
#19
Julia Lackner, Daniela Schlichting, Christine Müller-Graf, Matthias Greiner
Bacteria of the genus Campylobacter spp. are one of the most common causes of gastroenteritis and can lead to serious sequelae. Several studies have estimated the disease burden of Campylobacter spp. with the quantitative metric of disability-adjusted life years (DALY). The aim of this systematic review is to give an overview of the information available about different countries and periods for which DALYs were calculated and how the different results are comparable. One of the most important transmission pathways for Campylobacter spp...
December 7, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29178886/physical-examination-in-undergraduate-medical-education-in-the-field-of-general-practice-a-scoping-review
#20
Dirk Moßhammer, Joachim Graf, Stefanie Joos, Rebekka Hertkorn
BACKGROUND: Physical examination (PE) is an essential clinical skill and a central part of a physician's daily activity. Teaching of PE has been integrated into medical school by many clinical disciplines with respective specific examination procedures. For instance, PE teaching in general practice may include a full-body examination approach. Studies show that PE-skills of medical students often need enhancement. The aim of this article was to scope the literature regarding the teaching and research of PE within general practice during undergraduate medical education...
November 25, 2017: BMC Medical Education
keyword
keyword
85441
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"