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https://www.readbyqxmd.com/read/28400994/pathological-diagnosis-of-gastric-cancers-with-a-novel-computerized-analysis-system
#1
Kosuke Oikawa, Akira Saito, Tomoharu Kiyuna, Hans Peter Graf, Eric Cosatto, Masahiko Kuroda
BACKGROUND: Recent studies of molecular biology have provided great advances for diagnostic molecular pathology. Automated diagnostic systems with computerized scanning for sampled cells in fluids or smears are now widely utilized. Automated analysis of tissue sections is, however, very difficult because they exhibit a complex mixture of overlapping malignant tumor cells, benign host-derived cells, and extracellular materials. Thus, traditional histological diagnosis is still the most powerful method for diagnosis of diseases...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28399589/-identification-of-good-practice-projects-in-promoting-physical-activity-methods-pitfalls-and-sampled-outcomes
#2
Annette Henn, Claudia Karger, Katrin Wöhlken, Diana Meier, Ulrike Ungerer-Röhrich, Christine Graf, Alexander Woll
The aim of this paper is to identify and show examples of good practice of public health promotion. For this, uniform quality criteria were worked out under consideration of national and international scientific literature.For the identification of examples of good practice, a comparison of different quality criteria was carried out and combined with each other in a first step. In the following step, examples of good practice were identified after a comprehensive search. The choice of the "good-practice" projects is exemplary and lays no claim to completeness...
March 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28399581/-recommendations-for-physical-activity-and-sedentary-behaviour-for-children-and-adolescents-methods-database-and-rationale
#3
Christine Graf, Nina Ferrari, Ralph Beneke, Wilhelm Bloch, Stefanie Eiser, Benjamin Koch, Wolfgang Lawrenz, Susanne Krug, Kristin Manz, Renate Oberhoffer, Günter Stibbe, Alexander Woll
The benefits of physical activity and a reduction of sedentary behaviour in childhood and adolescence are well established.Based on a quality-assured literature review, the German recommendations were updated. Guidelines for infants, toddlers, children of kindergarten and primary school age and youth are clearly depictedIn general, a higher amount of physical activity is associated with more health benefits. Preschool age children should have 180 min of physical activity daily, and from primary school age on, at least 90 min daily are recommended...
March 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28378458/sensitivity-to-ischaemia-of-single-sympathetic-nerve-fibres-innervating-the-dorsum-of-the-human-foot
#4
W J Z'Graggen, R Solà, N E Graf, J Serra, H Bostock
The aim of this study was to determine whether velocity recovery cycles (VRCs) could detect the effects of ischaemia on sympathetic nerve fibres. VRCs of human sympathetic nerve fibres of the superficial peroneal nerve innervating the dorsum of the foot were recorded by microneurography in 7 healthy volunteers. Sympathetic nerve fibres were identified by studying their response to manoeuvres increasing sympathetic outflow and by measuring activity-dependent slowing at 2 Hz stimulation. VRCs were assessed at rest, during 30 min of induced limb ischaemia and during 20 min of recovery after ischaemia...
April 4, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28341489/automatic-evaluation-of-scan-adequacy-and-dysplasia-metrics-in-2-d-ultrasound-images-of-the-neonatal-hip
#5
Niamul Quader, Antony J Hodgson, Kishore Mulpuri, Emily Schaeffer, Rafeef Abugharbieh
Ultrasound (US) imaging of an infant's hip joint is widely used for early detection of developmental dysplasia of the hip. In current US-based diagnosis of developmental dysplasia of the hip, trained clinicians acquire US images and, if they judge them to be adequate (i.e., to contain relevant hip joint structures), analyze them manually to extract clinically useful dysplasia metrics. However, both the scan adequacy classification and dysplasia metrics extraction steps exhibit significant variability within and between both clinicians and institutions, which can result in significant over- and undertreatment rates...
March 21, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28333972/evaluation-of-high-resolution-in-vivo-mri-for-longitudinal-analysis-of-endochondral-fracture-healing-in-mice
#6
Melanie Haffner-Luntzer, Fabian Müller-Graf, Romano Matthys, Yvonne Hägele, Verena Fischer, René Jonas, Alireza Abaei, Florian Gebhard, Volker Rasche, Anita Ignatius
Mice are extensively used for experimental bone-healing studies. However, there are few established nondestructive in vivo techniques for longitudinal fracture-healing analysis in mice, including in vivo micro-computed tomography (μCT) and radiography. Importantly, none of the established methods can discriminate between non-mineralized fibrous tissue and cartilage in the soft fracture callus. Therefore, the objective was to establish high-resolution in vivo magnetic resonance imaging (MRI) for the longitudinal assessment of soft callus formation during bone healing in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28316836/comparison-of-progression-rate-of-retinal-pigment-epithelium-loss-in-patients-with-neovascular-age-related-macular-degeneration-treated-with-ranibizumab-and-aflibercept
#7
Juliana Wons, Magdalena A Wirth, Nicole Graf, Matthias D Becker, Stephan Michels
Purpose. Retinal pigment epithelium (RPE) loss in neovascular age-related macular degeneration (nAMD) seem to have a linear progression but might be influenced by the treatment. The purpose of the study is the comparison of RPE loss over three years in patients treated with intravitreal ranibizumab to patients who were switched to aflibercept. Methods. A retrospective analysis with 96 eyes switched to aflibercept was conducted. The progression rate of RPE loss was evaluated in patients who showed atrophy one year prior to switch (n = 17) or on switch date (n = 19)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28214447/influence-of-pressures-up-to-50bar-on-two-stage-anaerobic-digestion
#8
Wolfgang Merkle, Katharina Baer, Jonas Lindner, Simon Zielonka, Felix Ortloff, Frank Graf, Thomas Kolb, Thomas Jungbluth, Andreas Lemmer
The concept of pressurized two-stage anaerobic digestion integrates biogas production, purification and pressure boosting within one process. The produced methane-rich biogas can be fed into gas grids with considerably less purification effort. To investigate biogas production under high pressures up to 50bar, a lab scale two-stage anaerobic digestion system was constructed including one continuously operated pressurized methane reactor. This investigation examined the effects of different operating pressures in methane reactor (10, 25, 50bar) on biogas quantity and quality, pH value and process stability...
February 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28164474/traits-across-the-personality-hierarchy-differentially-relate-to-positive-and-negative-affect-evidence-for-the-predictive-validity-of-empirically-derived-meta-traits
#9
Michael P Hengartner, Markus Graf, Marc Schreiber
There is increasing interest in the construct validity of higher-order domains of the Big Five personality traits. A total of 831 persons from the Swiss population completed the International Personality Item Pool and an adaptation of the Positive and Negative Affect Scales. Using Goldberg's bass-ackwards method, we found evidence for the general factor of personality (GFP) and the two meta-traits of positive emotionality (blend of low neuroticism and high extraversion) and constraint (blend of high agreeableness and conscientiousness)...
February 6, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28107817/can-calculation-of-energy-expenditure-based-on-co2-measurements-replace-indirect-calorimetry
#10
Taku Oshima, Séverine Graf, Claudia-Paula Heidegger, Laurence Genton, Jérôme Pugin, Claude Pichard
BACKGROUND: Methods to calculate energy expenditure (EE) based on CO2 measurements (EEVCO2) have been proposed as a surrogate to indirect calorimetry. This study aimed at evaluating whether EEVCO2 could be considered as an alternative to EE measured by indirect calorimetry. METHODS: Indirect calorimetry measurements conducted for clinical purposes on 278 mechanically ventilated ICU patients were retrospectively analyzed. EEVCO2 was calculated by a converted Weir's equation using CO2 consumption (VCO2) measured by indirect calorimetry and assumed respiratory quotients (RQ): 0...
January 21, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28100407/pressure-ulcer-reconstruction-in-patients-with-heterotopic-ossification-after-spinal-cord-injury-a-case-series-and-review-of-literature
#11
REVIEW
Kai Yang, Alexander Graf, James Sanger
Heterotopic ossification (HO) is widely recognized as a common occurrence among patients suffering from traumatic spinal cord injuries (SCI). The exact etiology of HO formation remains unknown. Published medical and surgical management strategies are often plagued with questionable effectiveness and frequent complications. There are minimal publications regarding the management strategies of HO in SCI patients as it pertains to plastic surgery. We present a case series of patients treated at our institution who underwent treatment for pressure ulcers with underlying HO to highlight the vast spectrum of clinical phenotypes present in this population...
April 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28025728/semiautomatic-classification-of-acetabular-shape-from-three-dimensional-ultrasound-for-diagnosis-of-infant-hip-dysplasia-using-geometric-features
#12
Abhilash Rakkunedeth Hareendranathan, Dornoosh Zonoobi, Myles Mabee, Chad Diederichs, Kumaradevan Punithakumar, Michelle Noga, Jacob L Jaremko
PURPOSE: Developmental dysplasia of the hip (DDH) is a congenital deformity which in severe cases leads to hip dislocation and in milder cases to premature osteoarthritis. Image-aided diagnosis of DDH is partly based on Graf classification which quantifies the acetabular shape seen at two-dimensional ultrasound (2DUS), which leads to high inter-scan variance. 3D ultrasound (3DUS) is a promising alternative for more reliable DDH diagnosis. However, manual quantification of acetabular shape from 3DUS is cumbersome...
December 26, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27990423/size-does-not-make-the-difference-3d-4d-transperineal-sonographic-measurements-of-the-female-urethra-in-the-assessment-of-urinary-incontinence-subtypes
#13
Tomas Kupec, Ulrich Pecks, Charlotte M Gräf, Elmar Stickeler, Ivo Meinhold-Heerlein, Laila Najjari
Purpose. The objective was to evaluate the usefulness of transperineal ultrasound in the assessment of the urethral length and urethral lumen by 3D/4D transperineal sonography to discriminate between female patients with subtypes of urinary incontinence. Methods. A total of 150 female patients underwent an examination because of urinary incontinence. 41 patients were diagnosed with urgency urinary incontinence (OAB), 67 patients were diagnosed with stress urinary incontinence (SUI), and 42 patients were in the control group (CTRL)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27958731/the-cushion-method-a-new-technique-for-the-recovery-of-hydrophilic-nanocarriers
#14
Wei He, Robert Graf, Stefan Vieth, Ulrich Ziener, Katharina Landfester, Daniel Crespy
Microencapsulation of hydrophilic therapeutic agents such as proteins or nucleotides into a nanocarrier is frequently accomplished in inverse (water-in-oil) emulsions. However, the redispersion of the nanocarriers in aqueous media often involves a complicated purification process, and the redispersion usually requires additional surfactants for its colloidal stability, which is not favored for biological applications. We propose a simple, fast, and mild method to recover hydrophilic nanocarriers prepared in inverse emulsions by temporary coating of the nanocarriers with biocompatible small molecules, so that the final aqueous dispersion of the nanocarriers can be dispersed with high recovery rate, minimal aggregation, and no additional surfactants...
December 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27951600/multimodal-and-sequential-treatment-improves-survival-in%C3%A2-patients-with-hepatocellular-carcinoma
#15
Thomas Göbel, Dirk Graf, Christina Hosnowsky, Dirk Blondin, Wolfram Trudo Knoefel, Dieter Häussinger, Andreas Erhardt
Background and aims Therapy of hepatocellular carcinoma (HCC) mainly depends on tumor stage and liver function. The aim of this study was to identify additional predictors of overall survival in HCC patients with a particular attention to multimodal therapies. Methods Six hundred and seven consecutive HCC-patients treated in a tertiary center between 1988 and 2011 were retrospectively analyzed. Multivariate analysis was performed by logistic and Cox-regression, overall survival was analyzed by Kaplan Meier statistics...
March 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27931353/game-changing-innovation-in-chemical-production-methods-concepts-examples
#16
Xenia Beyrich-Graf
No abstract text is available yet for this article.
September 2016: Chimia
https://www.readbyqxmd.com/read/27919386/donor-s-support-tool-enabling-informed-secondary-use-of-patient-s-biomaterial-and-personal-data
#17
Haridimos Kondylakis, Lefteris Koumakis, Stephanie Hänold, Iheanyi Nwankwo, Nikolaus Forgó, Kostas Marias, Manolis Tsiknakis, Norbert Graf
PURPOSE: Biomedical research is being catalyzed by the vast amount of data rapidly collected through the application of information technologies (IT). Despite IT advances, the methods for involving patients and citizens in biomedical research remain static, paper-based and organized around national boundaries and anachronistic legal frameworks. The purpose of this paper is to study the current practices for obtaining consent for biobanking and the legal requirements for reusing the available biomaterial and data in EU and finally to present a novel tool to this direction enabling the secondary use of data and biomaterial...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27784123/-cost-effectiveness-of-pharmacological-smoking-cessation-therapies-a-systematic-literature-review
#18
I Aumann, K Rozanski, K Damm, J-M Graf von der Schulenburg
Aim of the Study: Through the promotion of smoking cessation premature mortality can be prevented. Therefore it is necessary to provide effective and cost-effective smoking cessation interventions. In Germany the cost of pharmacological smoking cessation measures are not yet reimbursed by the statutory health insurance. The aim of this study is to present the evidence on the cost-effectiveness of already approved pharmacological smoking cessation therapies and to evaluate their quality. Method: A systematic literature research was conducted in the databases by DIMDI (Medline, Embase, etc...
October 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27761027/health-related-quality-of-life-in-metastatic-and-adjuvant-breast-cancer-patients
#19
M Wallwiener, E Simoes, A N Sokolov, S Y Brucker, P A Fasching, J Graf
Introduction: When cancer patients have advanced disease and a primary cure is no longer possible, the focus is on maintaining the patient's quality of life. Recent therapeutic advances in breast cancer treatment mean that even patients with metastatic disease can remain stable for long periods of time. The aim of this study was to look at the health-related quality of life (HRQL) of these patients and compare it with data for the general population and to show the differences in outcomes for different survey instruments used to measure quality of life...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27736695/habitat-use-and-tolerance-levels-of-macroinvertebrates-concerning-hydraulic-stress-in-hydropeaking-rivers-a-case-study-at-the-ziller-river-in-austria
#20
P Leitner, C Hauer, W Graf
Artificial flow fluctuations due to the operation of hydropower plants, frequently described as hydropeaking, result in a constant decrease of biomass of specific macrozoobenthos (MZB) taxa. For the presented case study, we assessed three reaches in the Ziller River catchment. At each sampling reach we performed the Multi-Habitat-Sampling (MHS) method with a Water Framework Directive (WFD) compliant AQEM/MHS net according to the Austrian guideline. Additionally, a hydraulic-specific sampling was conducted with a modified Box (Surber) sampler...
January 1, 2017: Science of the Total Environment
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