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https://www.readbyqxmd.com/read/28214447/influence-of-pressures-up-to-50bar-on-two-stage-anaerobic-digestion
#1
Wolfgang Merkle, Katharina Baer, Jonas Lindner, Simon Zielonka, Felix Ortloff, Frank Graf, Thomas Kolb, Thomas Jungbluth, Andreas Lemmer
The concept of pressurized two-stage anaerobic digestion integrates biogas production, purification and pressure boosting within one process. The produced methane-rich biogas can be fed into gas grids with considerably less purification effort. To investigate biogas production under high pressures up to 50bar, a lab scale two-stage anaerobic digestion system was constructed including one continuously operated pressurized methane reactor. This investigation examined the effects of different operating pressures in methane reactor (10, 25, 50bar) on biogas quantity and quality, pH value and process stability...
February 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28164474/traits-across-the-personality-hierarchy-differentially-relate-to-positive-and-negative-affect-evidence-for-the-predictive-validity-of-empirically-derived-meta-traits
#2
Michael P Hengartner, Markus Graf, Marc Schreiber
There is increasing interest in the construct validity of higher-order domains of the Big Five personality traits. A total of 831 persons from the Swiss population completed the International Personality Item Pool and an adaptation of the Positive and Negative Affect Scales. Using Goldberg's bass-ackwards method, we found evidence for the general factor of personality (GFP) and the two meta-traits of positive emotionality (blend of low neuroticism and high extraversion) and constraint (blend of high agreeableness and conscientiousness)...
February 6, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28107817/can-calculation-of-energy-expenditure-based-on-co2-measurements-replace-indirect-calorimetry
#3
Taku Oshima, Séverine Graf, Claudia-Paula Heidegger, Laurence Genton, Jérôme Pugin, Claude Pichard
BACKGROUND: Methods to calculate energy expenditure (EE) based on CO2 measurements (EEVCO2) have been proposed as a surrogate to indirect calorimetry. This study aimed at evaluating whether EEVCO2 could be considered as an alternative to EE measured by indirect calorimetry. METHODS: Indirect calorimetry measurements conducted for clinical purposes on 278 mechanically ventilated ICU patients were retrospectively analyzed. EEVCO2 was calculated by a converted Weir's equation using CO2 consumption (VCO2) measured by indirect calorimetry and assumed respiratory quotients (RQ): 0...
January 21, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28100407/pressure-ulcer-reconstruction-in-patients-with-heterotopic-ossification-after-spinal-cord-injury-a-case-series-and-review-of-literature
#4
REVIEW
Kai Yang, Alexander Graf, James Sanger
Heterotopic ossification (HO) is widely recognized as a common occurrence among patients suffering from traumatic spinal cord injuries (SCI). The exact etiology of HO formation remains unknown. Published medical and surgical management strategies are often plagued with questionable effectiveness and frequent complications. There are minimal publications regarding the management strategies of HO in SCI patients as it pertains to plastic surgery. We present a case series of patients treated at our institution who underwent treatment for pressure ulcers with underlying HO to highlight the vast spectrum of clinical phenotypes present in this population...
December 21, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28025728/semiautomatic-classification-of-acetabular-shape-from-three-dimensional-ultrasound-for-diagnosis-of-infant-hip-dysplasia-using-geometric-features
#5
Abhilash Rakkunedeth Hareendranathan, Dornoosh Zonoobi, Myles Mabee, Chad Diederichs, Kumaradevan Punithakumar, Michelle Noga, Jacob L Jaremko
PURPOSE: Developmental dysplasia of the hip (DDH) is a congenital deformity which in severe cases leads to hip dislocation and in milder cases to premature osteoarthritis. Image-aided diagnosis of DDH is partly based on Graf classification which quantifies the acetabular shape seen at two-dimensional ultrasound (2DUS), which leads to high inter-scan variance. 3D ultrasound (3DUS) is a promising alternative for more reliable DDH diagnosis. However, manual quantification of acetabular shape from 3DUS is cumbersome...
December 26, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27990423/size-does-not-make-the-difference-3d-4d-transperineal-sonographic-measurements-of-the-female-urethra-in-the-assessment-of-urinary-incontinence-subtypes
#6
Tomas Kupec, Ulrich Pecks, Charlotte M Gräf, Elmar Stickeler, Ivo Meinhold-Heerlein, Laila Najjari
Purpose. The objective was to evaluate the usefulness of transperineal ultrasound in the assessment of the urethral length and urethral lumen by 3D/4D transperineal sonography to discriminate between female patients with subtypes of urinary incontinence. Methods. A total of 150 female patients underwent an examination because of urinary incontinence. 41 patients were diagnosed with urgency urinary incontinence (OAB), 67 patients were diagnosed with stress urinary incontinence (SUI), and 42 patients were in the control group (CTRL)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27958731/the-cushion-method-a-new-technique-for-the-recovery-of-hydrophilic-nanocarriers
#7
Wei He, Robert Graf, Stefan Vieth, Ulrich Ziener, Katharina Landfester, Daniel Crespy
Microencapsulation of hydrophilic therapeutic agents such as proteins or nucleotides into a nanocarrier is frequently accomplished in inverse (water-in-oil) emulsions. However, the redispersion of the nanocarriers in aqueous media often involves a complicated purification process, and the redispersion usually requires additional surfactants for its colloidal stability, which is not favored for biological applications. We propose a simple, fast, and mild method to recover hydrophilic nanocarriers prepared in inverse emulsions by temporary coating of the nanocarriers with biocompatible small molecules, so that the final aqueous dispersion of the nanocarriers can be dispersed with high recovery rate, minimal aggregation, and no additional surfactants...
December 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27951600/multimodal-and-sequential-treatment-improves-survival-in%C3%A2-patients-with-hepatocellular-carcinoma
#8
Thomas Göbel, Dirk Graf, Christina Hosnowsky, Dirk Blondin, Wolfram Trudo Knoefel, Dieter Häussinger, Andreas Erhardt
Background and aims Therapy of hepatocellular carcinoma (HCC) mainly depends on tumor stage and liver function. The aim of this study was to identify additional predictors of overall survival in HCC patients with a particular attention to multimodal therapies. Methods Six hundred and seven consecutive HCC-patients treated in a tertiary center between 1988 and 2011 were retrospectively analyzed. Multivariate analysis was performed by logistic and Cox-regression, overall survival was analyzed by Kaplan Meier statistics...
March 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27931353/game-changing-innovation-in-chemical-production-methods-concepts-examples
#9
Xenia Beyrich-Graf
No abstract text is available yet for this article.
September 2016: Chimia
https://www.readbyqxmd.com/read/27919386/donor-s-support-tool-enabling-informed-secondary-use-of-patient-s-biomaterial-and-personal-data
#10
Haridimos Kondylakis, Lefteris Koumakis, Stephanie Hänold, Iheanyi Nwankwo, Nikolaus Forgó, Kostas Marias, Manolis Tsiknakis, Norbert Graf
PURPOSE: Biomedical research is being catalyzed by the vast amount of data rapidly collected through the application of information technologies (IT). Despite IT advances, the methods for involving patients and citizens in biomedical research remain static, paper-based and organized around national boundaries and anachronistic legal frameworks. The purpose of this paper is to study the current practices for obtaining consent for biobanking and the legal requirements for reusing the available biomaterial and data in EU and finally to present a novel tool to this direction enabling the secondary use of data and biomaterial...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27784123/-cost-effectiveness-of-pharmacological-smoking-cessation-therapies-a-systematic-literature-review
#11
I Aumann, K Rozanski, K Damm, J-M Graf von der Schulenburg
Aim of the Study: Through the promotion of smoking cessation premature mortality can be prevented. Therefore it is necessary to provide effective and cost-effective smoking cessation interventions. In Germany the cost of pharmacological smoking cessation measures are not yet reimbursed by the statutory health insurance. The aim of this study is to present the evidence on the cost-effectiveness of already approved pharmacological smoking cessation therapies and to evaluate their quality. Method: A systematic literature research was conducted in the databases by DIMDI (Medline, Embase, etc...
October 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27761027/health-related-quality-of-life-in-metastatic-and-adjuvant-breast-cancer-patients
#12
M Wallwiener, E Simoes, A N Sokolov, S Y Brucker, P A Fasching, J Graf
Introduction: When cancer patients have advanced disease and a primary cure is no longer possible, the focus is on maintaining the patient's quality of life. Recent therapeutic advances in breast cancer treatment mean that even patients with metastatic disease can remain stable for long periods of time. The aim of this study was to look at the health-related quality of life (HRQL) of these patients and compare it with data for the general population and to show the differences in outcomes for different survey instruments used to measure quality of life...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27736695/habitat-use-and-tolerance-levels-of-macroinvertebrates-concerning-hydraulic-stress-in-hydropeaking-rivers-a-case-study-at-the-ziller-river-in-austria
#13
P Leitner, C Hauer, W Graf
Artificial flow fluctuations due to the operation of hydropower plants, frequently described as hydropeaking, result in a constant decrease of biomass of specific macrozoobenthos (MZB) taxa. For the presented case study, we assessed three reaches in the Ziller River catchment. At each sampling reach we performed the Multi-Habitat-Sampling (MHS) method with a Water Framework Directive (WFD) compliant AQEM/MHS net according to the Austrian guideline. Additionally, a hydraulic-specific sampling was conducted with a modified Box (Surber) sampler...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27723282/rheumatoid-arthritis-naive-t-cells-share-hypermethylation-sites-with-synoviocytes
#14
Brooke Rhead, Calliope Holingue, Michael Cole, Xiaorong Shao, Hong L Quach, Diana Quach, Khooshbu Shah, Elizabeth Sinclair, John Graf, Thomas Link, Ruby Harrison, Elior Rahmani, Eran Halperin, Wei Wang, Gary S Firestein, Lisa F Barcellos, Lindsey A Criswell
OBJECTIVE: To determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples. METHODS: For this study, 371 genome-wide DNA methylation profiles were measured using Illumina HumanMethylation450 BeadChips in PB samples from 63 patients with RA and 31 unaffected control subjects, specifically in the cell subsets of CD14+ monocytes, CD19+ B cells, CD4+ memory T cells, and CD4+ naive T cells...
March 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27716184/amino-acid-pet-versus-mri-guided-re-irradiation-in-patients-with-recurrent-glioblastoma-multiforme-gliaa-protocol-of-a-randomized-phase-ii-trial-noa-10-aro-2013-1
#15
Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G Baumert, Susan C Short, Philipp T Meyer, Wolfgang A Weber, Anca-Ligia Grosu
BACKGROUND: The higher specificity of amino-acid positron emission tomography (AA-PET) in the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment-related alterations, in comparison to contrast enhancement in T1-weighted MRI was demonstrated in many studies and is the rationale for their implementation into radiation oncology treatment planning. Several clinical trials have demonstrated the significant differences between AA-PET and standard MRI concerning the definition of the gross tumor volume (GTV)...
October 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27698744/clinical-evaluation-of-ultrasound-screening-in-follow-up-visits-of-infants-with-cerebral-palsy-at-high-risk-for-developmental-dysplasia-of-the-hip
#16
Aizhen Qiu, Zhongxiu Yang, Jiping Wang, Taotao Wang
The aim of the study was to assess the clinical value of ultrasound screenings for the developmental dysplasia of the hip (DDH) and explore its etiology in high-risk infants with cerebral palsy in follow-up visits. A group of 98 cases of infants at high-risk of cerebral palsy who received rehabilitation treatment between July, 2009 and July, 2010 were selected. Infants included 58 men and 40 women, aged <6 months and not lost to follow-up visits. Ultrasound (using Graf static inspection) screening of hips was performed and the infants with abnormalities were given clinical intervention, and 1- to 2-year-old infants were given outpatient follow-ups...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27688927/a-novel-method-for-morphological-pleomorphism-and-heterogeneity-quantitative-measurement-named-cell-feature-level-co-occurrence-matrix
#17
Akira Saito, Yasushi Numata, Takuya Hamada, Tomoyoshi Horisawa, Eric Cosatto, Hans-Peter Graf, Masahiko Kuroda, Yoichiro Yamamoto
BACKGROUND: Recent developments in molecular pathology and genetic/epigenetic analysis of cancer tissue have resulted in a marked increase in objective and measurable data. In comparison, the traditional morphological analysis approach to pathology diagnosis, which can connect these molecular data and clinical diagnosis, is still mostly subjective. Even though the advent and popularization of digital pathology has provided a boost to computer-aided diagnosis, some important pathological concepts still remain largely non-quantitative and their associated data measurements depend on the pathologist's sense and experience...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27662383/graf-type-iv-hips-have-a-higher-risk-of-residual-acetabular-dysplasia-at-1-year-of-age-following-successful-pavlik-harness-treatment-for-developmental-hip-dysplasia
#18
Eduardo N Novais, Julia Sanders, Lauryn A Kestel, Patrick M Carry, Mariana L Meyers
BACKGROUND: We asked whether patient-specific factors and ultrasound (US) measurements of hip dysplasia severity at initial examination influence short-term residual acetabular dysplasia in patients successfully treated with Pavlik harness for developmental hip dysplasia. METHODS: After IRB approval, 134 hips (84 patients) successfully treated by the Pavlik method between August 2011 and October 2014 with follow-up at 12 months of age were identified. Early successful treatment was defined as normal examination and US after approximately 12 weeks of Pavlik treatment...
September 22, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27646538/game-changing-innovation-in-chemical-production-methods-concepts-examples
#19
Xenia Beyrich-Graf
No abstract text is available yet for this article.
September 2016: Chimia
https://www.readbyqxmd.com/read/27634475/free-energy-calculations-of-residue-mutations-in-a-tripeptide-using-various-methods-to-overcome-inefficient-sampling
#20
Michael M H Graf, Manuela Maurer, Chris Oostenbrink
Previous free-energy calculations have shown that the seemingly simple transformation of the tripeptide KXK to KGK in water holds some unobvious challenges concerning the convergence of the forward and backward thermodynamic integration processes (i.e., hysteresis). In the current study, the central residue X was either alanine, serine, glutamic acid, lysine, phenylalanine, or tyrosine. Interestingly, the transformation from alanine to glycine yielded the highest hysteresis in relation to the extent of the chemical change of the side chain...
November 5, 2016: Journal of Computational Chemistry
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