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Optical coherence tomography barrett's

Jack X Ma, Maolong Tang, Li Wang, Mitchell P Weikert, David Huang, Douglas D Koch
PURPOSE: To evaluate the accuracy of the optical coherence tomography-based (OCT formula) and Barrett True K (True K) intraocular lens (IOL) calculation formulas in eyes with previous radial keratotomy (RK). METHODS: In 95 eyes of 65 patients, using the actual refraction following cataract surgery as target refraction, the predicted IOL power for each method was calculated. The IOL prediction error (PE) was obtained by subtracting the predicted IOL power from the implanted IOL power...
July 1, 2016: Investigative Ophthalmology & Visual Science
Hajime Isomoto
No abstract text is available yet for this article.
May 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Ashley H Davis-Yadley, Kevin G Neill, Mokenge P Malafa, Luis R Pena
BACKGROUND: Barrett esophagus (BE) continues to be a major risk factor for developing esophageal adenocarcinoma. METHODS: We review the risk factors, diagnosis, and management of BE, with an emphasis on the most current endoscopic diagnostic modalities for BE. RESULTS: Novel diagnostic modalities have emerged to address the inadequacies of standard, untargeted biopsies, such as dye-based and virtual chromoendoscopy, endoscopic mucosal resection, molecular biomarkers, optical coherence tomography, confocal laser endomicroscopy, volumetric laser endomicroscopy, and endocytoscopy...
January 2016: Cancer Control: Journal of the Moffitt Cancer Center
Giovanni J Ughi, Michalina J Gora, Anne-Fré Swager, Amna Soomro, Catriona Grant, Aubrey Tiernan, Mireille Rosenberg, Jenny S Sauk, Norman S Nishioka, Guillermo J Tearney
Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barrett's esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further referred for upper endoscopy...
February 1, 2016: Biomedical Optics Express
Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Naoki Asano, Katsunori Iijima, Akira Imatani, Fumiyoshi Fujishima, Tooru Shimosegawa
OBJECTIVES: The evaluation of Barrett's glands buried underneath esophageal squamous epithelium becomes increasingly important to achieve curative treatments. However, clinically available endoscopies have critical limitations in depicting the subsurface structure, resulting in non-curative treatments. Optical coherence tomography (OCT) can acquire a high-resolution cross-sectional image, equivalent to an 'optical biopsy'. We aimed to assess the feasibility of the in vivo use of probe-type OCT imaging to evaluate Barrett's mucosa buried underneath esophageal squamous epithelium METHODS: We conducted a single-center prospective study with 14 consecutive patients with Barrett's adenocarcinoma from 2008 to 2014...
November 19, 2015: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Prateek Sharma, Joel Brill, Marcia Canto, Daniel DeMarco, Brian Fennerty, Neil Gupta, Loren Laine, David Lieberman, Charles Lightdale, Elizabeth Montgomery, Robert Odze, Jeffrey Tokar, Michael Kochman
Enhanced imaging technologies such as narrow band imaging, flexible spectral imaging color enhancement, i-Scan, confocal laser endomicroscopy, and optical coherence tomography are readily available for use by endoscopists in routine clinical practice. In November 2014, the American Gastroenterological Association's Center for GI Innovation and Technology conducted a 2-day workshop to discuss endoscopic image enhancement technologies, focusing on their role in 2 specific clinical conditions (colon polyps and Barrett's esophagus) and on issues relating to training and implementation of these technologies (white papers)...
December 2015: Clinical Gastroenterology and Hepatology
Li Wang, Maolong Tang, David Huang, Mitchell P Weikert, Douglas D Koch
PURPOSE: To compare the newer formulae, the optical coherence tomography (OCT)-based intraocular lens (IOL) power formula (OCT formula) and the Barrett True-K formula (True-K), with the methods on the American Society of Cataract and Refractive Surgery (ASCRS) calculator in eyes with previous myopic LASIK/photorefractive keratectomy (PRK). DESIGN: Prospective case series. PARTICIPANTS: A total of 104 eyes of 80 patients who had previous myopic LASIK/PRK and subsequent cataract surgery and IOL implantation...
December 2015: Ophthalmology
Dianne Barrett, Jin Yang, Tharikarn Sujirakul, Stephen H Tsang
Vigabatrin is an effective antiepileptic drug (AED) typically used in the treatment of refractory partial seizures and infantile spasms. Its use, however, is limited due to the concern of retinal toxicity and subsequent visual field defects. Herewith in we describe a case of vigabatrin toxicity that illustrates electroretinographic (ERG) changes occur before imaging and visual field deterioration. Decrease in maximal ERG b: a ratio was observed before thinning of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT)...
2014: Journal of Clinical & Experimental Ophthalmology
Kaname Uno, Tomoyuki Koike, Tooru Shimosegawa
Endoscopic diagnosis with histological evidence is necessary to decide the best strategy for treating esophageal squamous cell carcinoma and Barrett's-associated neoplasia, and the recent development of endoscopic technologies have made possible real-time information of malignant hallmarks. We focused on the development of optical coherence tomography (OCT), the only technology that can depict real-time cross-sectional images with high resolution. With the improvements in image resolution, acquisition rate and demonstrable area of three-dimensional devices with Doppler capability, OCT imaging was shown to enable visualization of structural/functional alterations in the mucosal/submucosal tissue of the esophagus, resulting in more accurate preoperative diagnosis of such malignancies...
July 25, 2015: World Journal of Gastrointestinal Endoscopy
Anne-Fré Swager, David F Boerwinkel, Daniel M de Bruin, Dirk J Faber, Ton G van Leeuwen, Bas L Weusten, Sybren L Meijer, Jacques J Bergman, Wouter L Curvers
BACKGROUND AND AIMS: The prevalence and clinical relevance of buried Barrett's glands (BB) after radiofrequency ablation (RFA) in Barrett's esophagus (BE) are debated. Recent optical coherence tomography studies demonstrated a high prevalence of BBs. Direct histological correlation, however, has been lacking. Volumetric laser endomicroscopy (VLE) is a second-generation optical coherence tomography system capable of scanning a large surface of the esophageal wall layers with low-power microscopy resolution...
January 2016: Gastrointestinal Endoscopy
Matthew B Sturm, Thomas D Wang
The rapid rise in incidence of oesophageal adenocarcinoma has motivated the need for improved methods for surveillance of Barrett's oesophagus. Early neoplasia is flat in morphology and patchy in distribution and is difficult to detect with conventional white light endoscopy (WLE). Light offers numerous advantages for rapidly visualising the oesophagus, and advanced optical methods are being developed for wide-field and cross-sectional imaging to guide tissue biopsy and stage early neoplasia, respectively. We review key features of these promising methods and address their potential to improve detection of Barrett's neoplasia...
November 2015: Gut
A Swager, D F Boerwinkel, D M de Bruin, B L Weusten, D J Faber, S L Meijer, T G van Leeuwen, W L Curvers, J J Bergman
Volumetric laser endomicroscopy (VLE) is a novel balloon-based optical coherence tomography (OCT) imaging technique that may improve detection of early neoplasia in Barrett's esophagus (BE). Most OCT studies lack a direct correlation between histology and OCT images. The aim is to investigate the optimal approach for achieving one-to-one correlation of ex-vivo VLE images of endoscopic resection (ER) specimens with histology. BE patients with and without early neoplasia underwent ER after delineating areas with electrocoagulation markers (ECM)...
August 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Kathy Beaudette, Hyoung Won Baac, Wendy-Julie Madore, Martin Villiger, Nicolas Godbout, Brett E Bouma, Caroline Boudoux
Double-clad fiber (DCF) is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and co-registered optical coherence tomography (OCT) and laser tissue coagulation. The DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light. We herein present a novel DCFC designed and built to combine both signals within a DCF (>90% of single-mode transmission; >65% multimode coupling)...
April 1, 2015: Biomedical Optics Express
Lourdes Y Robles, Satish Singh, Piero Marco Fisichella
BACKGROUND: Despite advances in diagnoses and therapy, esophageal adenocarcinoma remains a highly lethal neoplasm. Hence, a great interest has been placed in detecting early lesions and in the detection of Barrett esophagus (BE). Advanced imaging technologies of the esophagus have then been developed with the aim of improving biopsy sensitivity and detection of preplastic and neoplastic cells. The purpose of this article was to review emerging imaging technologies for esophageal pathology, spectroscopy, confocal laser endomicroscopy (CLE), and optical coherence tomography (OCT)...
May 15, 2015: Journal of Surgical Research
Rajvinder Singh, Sze Pheh Yeap
Barrett's esophagus is the only known precursor that predisposes patients to the development of esophageal adenocarcinoma. The current recommended surveillance method is targeted biopsies of any abnormalities followed by random four-quadrant biopsies every 2 cm using standard white light endoscopy. Compliance with this and sampling error are two of the biggest problems. Several novel imaging technologies have been developed to aid the diagnosis of early neoplasia in Barrett's esophagus. There are emerging data that some of these new modalities can increase the yield of detecting dysplasia...
April 2015: Expert Review of Gastroenterology & Hepatology
Junichi Akiyama, Srinadh Komanduri, Vani J A Konda, Hiroshi Mashimo, Sabrena Noria, George Triadafilopoulos
The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the endoscopic tools to recognize squamous cell dysplasia; confocal laser endomicroscopy for Barrett's esophagus; confocal microscopy in the cancer patient; optical coherence tomography in the assessment of subsquamous Barrett's metaplasia; endoscopic mucosal resection for high-grade dysplasia in Barrett's esophagus; HALO in the treatment of squamous dysplasia; and the use of fluorescence in situ hybridization to detect dysplasia and adenocarcinoma in patients with Barrett's esophagus...
September 2014: Annals of the New York Academy of Sciences
Tsung-Han Tsai, Osman O Ahsen, Hsiang-Chieh Lee, Kaicheng Liang, Marisa Figueiredo, Yuankai K Tao, Michael G Giacomelli, Benjamin M Potsaid, Vijaysekhar Jayaraman, Qin Huang, Alex E Cable, James G Fujimoto, Hiroshi Mashimo
No abstract text is available yet for this article.
December 2014: Gastroenterology
Vani J A Konda, Ann Koons, Uzma D Siddiqui, Shu-Yuan Xiao, Jerrold R Turner, Irving Waxman
No abstract text is available yet for this article.
September 2014: Gastrointestinal Endoscopy
H Barr, C Kendall, N Stone
BACKGROUND: Barrett's oesophagus is the columnar-lined metaplasia that occurs in response to severe gastro-oesophageal reflux and accounts for the dramatic rise in adenocarcinoma at the gastro-oesophageal junction. DIAGNOSTIC METHODS: Endoscopic recognition and pathological diagnosis of the condition is fraught with erroneous interpretation of the pre-malignant degeneration of dysplasia. Screening and surveillance programmes have yet to impact on the disease. Photodiagnosis by spectroscopy and imaging is under intense investigation...
May 2004: Photodiagnosis and Photodynamic Therapy
Thomas Tien, Tetsuya Muto, Kevin Barrette, Lucky Challyandra, Sayon Roy
PURPOSE: To determine whether downregulation of Connexin 43 (Cx43) expression promotes development of acellular capillaries (ACs), pericyte loss (PL), excess permeability, and retinal thickening in rat retinas. METHODS: Control rats, diabetic rats, and rats intravitreally injected with Cx43 siRNA or scrambled siRNA were used in this study to determine if acute downregulation of Cx43 expression contributes to retinal vascular cell death and excess permeability. Western blot (WB) analysis and Cx43 immunostaining were performed to assess Cx43 protein levels and distribution in the retinal vessels...
2014: Molecular Vision
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