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https://www.readbyqxmd.com/read/28065582/bivalent-flagellin-immunotherapy-protects-mice-against-pseudomonas-aeruginosa-infections-in-both-acute-pneumonia-and-burn-wound-models
#1
Hosein Ahmadi, Bahador Behrouz, Gholamreza Irajian, Nour Amirmozafari, Sara Naghavi
Pseudomonas aeruginosa infections are a serious challenge to therapy because of the complex pathogenesis and paucity of new effective antibiotics, thus renewing interest in antibody-based therapeutic strategies. Immunotherapy strategies typically target selected virulence factors that are expressed by the majority of clinical strains of P. aeruginosa, particularly because virulence factors mediate infection. Type a and b flagellins (flagellin a+b) of P. aeruginosa are acute virulence factors that play a major role in the establishment of infection...
January 5, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28032108/faunal-distribution-and-seasonal-bio-ecology-of-naturally-infected-sand-flies-in-a-new-endemic-zoonotic-cutaneous-leishmaniasis-focus-of-southern-iran
#2
Kourosh Azizi, Hayedeh Parvinjahromi, Mohammad Djaefar Moemenbellah-Fard, Bahador Sarkari, Mohammad Reza Fakoorziba
BACKGROUND: Cutaneous leishmaniasis is a major health problem in Iran in spite of implementation of control program. This infectious disease caused morbidity in less than 27000 people in 2010. This study was set to determine some ecological aspects of sand flies in Fasa district, Fars Province, southern Iran during 2011-2012. METHODS: A total of 4792 sand flies were captured by means of sticky paper and CDC miniature light traps in 10 selected villages from the beginning to the end of the active season, from which 1115 specimens were captured for abundance study and 3677 specimens captured for monitoring monthly activities in Fasa...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/27957297/perforated-meckel-s-diverticulum-in-a-3-day-old-neonate-a-case-report
#3
Mehdi Frooghi, Ali Bahador, Alireza Golchini, Mahmood Haghighat, Maryam Ataollahi, Hazhir Javaherizadeh
Perforation of Meckel's diverticulum is a rare complication in neonatal period. A 3-dayold term male neonate was transferred to our emergency room due to bowel perforation. Surgical exploration was done and perforated Meckel's diverticulum was detected. Pathological report of the tissue showed inflamed diverticulum with heterotopic gastric mucosa. This is the first report of Meckel's diverticulum perforation in a neonate in our country.
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27921405/thrombolytic-therapy-up-regulates-inflammatory-mediators-compared-to-percutaneous-coronary-intervention-pci
#4
Alireza Garjani, Bahram Sohrabi, Ali Akbar Movassaghpour, Sina Andalib, Mehriar Shokri, Bahar Taherkhanchi, Bahador Bagheri
The important role of reperfusion therapies in the treatment of acute myocardial infarction is well documented. However, reperfusion therapies can initiate inflammatory response and may damage the myocardium. The purpose of current study was to compare the effects of percutaneous coronary intervention and thrombolytic therapy on inflammatory markers in the setting of ST elevation myocardial infarction (STEMI). Eighty three patients with STEMI were enrolled in this study. 40 patients underwent percutaneous coronary intervention (PCI), and 43 patients received streptokinase (1...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27904603/prevalence-of-nontuberculous-mycobacteria-isolated-from-environmental-samples-in-iran-a-meta-analysis
#5
REVIEW
Azad Khaledi, Abbas Bahador, Davood Esmaeili, Alireza Tafazoli, Kiarash Ghazvini, Davood Mansury
BACKGROUND: While the most nontuberculous mycobacteria (NTMs) species are considered as opportunistic pathogens, some of them are related to several human infections. It is believed that environment is the main source for these infections. Distribution and scattering pattern of NTMs has not been well studied in Iran and a few studies about this subject have been done, so the aim of this study was to determine prevalence of NTMs in environmental samples from Iran. MATERIALS AND METHODS: Data about prevalence of NTMs in environmental samples from Iran were obtained by searching databases...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27890593/evaluation-of-the-crystal-structure-of-a-fimbrillin-fima-from-porphyromonas-gingivalis-as-a-therapeutic-target-for-photo-activated-disinfection-with-toluidine-blue-o
#6
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Porphyromonas gingivalis is one of the etiological agents in the initiation of combined periodontal-endodontic (perio-endo) lesions. Successful treatment of perio-endo lesions with photo-activated disinfection (PAD) as a novel therapeutic approach depends on the selection of an appropriate target site, specific photosensitizer (PS), and wavelength of light. Since the fimbrillin (FimA) is the most important pathogenic agent in P. gingivalis it was evaluated as a target site against PAD with toluidine blue O (TBO) as a PS...
November 23, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27884121/prevalence-and-risk-factors-of-intestinal-protozoan-infections-a-population-based-study-in-rural-areas-of-boyer-ahmad-district-southwestern-iran
#7
Bahador Sarkari, Ghasem Hosseini, Mohammad Hossein Motazedian, Mohammad Fararouei, Abdolali Moshfe
BACKGROUND: Parasitic infections are still a significant health problem in rural areas in developing countries including Iran. There is no recent population-based data about the prevalence of human intestinal parasites in most rural areas of Iran. The current study aimed to determine the prevalence of intestinal protozoan infection in inhabitants of rural areas of Boyer-Ahmad district, Southwestern Iran. METHODS: A total of 1025 stool samples were collected from the inhabitant of 50 randomly selected villages in Boyer-Ahmad Township...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27875149/visualization-by-demonstration-an-interaction-paradigm-for-visual-data-exploration
#8
Bahador Saket, Hannah Kim, Eli T Brown, Alex Endert
Although data visualization tools continue to improve, during the data exploration process many of them require users to manually specify visualization techniques, mappings, and parameters. In response, we present the Visualization by Demonstration paradigm, a novel interaction method for visual data exploration. A system which adopts this paradigm allows users to provide visual demonstrations of incremental changes to the visual representation. The system then recommends potential transformations (Visual Representation, Data Mapping, Axes, and View Specification transformations) from the given demonstrations...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27871827/asymptomatic-infection-with-mycoplasma-hominis-negatively-affects-semen-parameters-and-leads-to-male-infertility-as-confirmed-by-improved-semen-parameters-after-antibiotic-treatment
#9
Mohammad Hossein Ahmadi, Akbar Mirsalehian, Mohammad Ali Sadighi Gilani, Abbas Bahador, Malihe Talebi
OBJECTIVE: To elucidate the association between asymptomatic infections caused by Mycoplasma hominis and male infertility and to evaluate the role of antibiotic therapy in the treatment of this failure. MATERIALS AND METHODS: A total of 165 infertile men having abnormal semen parameters (study group) as well as 165 healthy fertile men (control group) were included in this study. Semen samples were taken from all participants and, after analyzing for semen parameters, real-time polymerase chain reaction, microbial culture, and reactive oxygen species (ROS) as well as total antioxidant capacity (TAC) assays were performed...
November 18, 2016: Urology
https://www.readbyqxmd.com/read/27847411/zoonotic-intestinal-protozoan-of-the-wild-boars-sus-scrofa-in-persian-gulf-s-coastal-area-bushehr-province-southwestern-iran
#10
Kambiz Yaghoobi, Bahador Sarkari, Majid Mansouri, Mohammad Hossein Motazedian
AIM: Wild boars, Sus scrofa, are potential reservoirs of many zoonotic diseases, and there are a possibility of transmission of the zoonotic diseases from these animals to humans and also domestic animals. This study aimed to evaluate the protozoan contamination of wild boars in the Persian Gulf's coastal area (Bushehr Province), southwestern Iran. MATERIALS AND METHODS: A total of 25 crossbred boars were collected during a course of vertebrate pest control in Bushehr province, in 2013...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27836762/passive-immunization-against-pseudomonas-aeruginosa-recombinant-pila-in-a-murine-burn-wound-model
#11
Mehdi Mousavi, Bahador Behrouz, Gholamreza Irajian, Mehdi Mahdavi, Fatemeh Korpi, Mohammad Motamedifar
Pseudomonas aeruginosa type IV pili have an essential role in twitching motility, colonization and biofilm formation. In this study, we investigated the efficacy of intraperitoneal administration of rabbit anti-recombinant PilA (anti-r-PilA) immunoglobulin G (IgG) against P. aeruginosa infection in a mouse burn-wound model. After burn and infection, mortality rate was assessed in all mice, and that of mice passively immunized with rabbit anti-r-PilA IgG was compared to non-immunized mice. Bacterial quantities in the skin and internal organs were measured to determine the level of systemic infection...
December 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27836582/antibodies-raised-against-divalent-type-b-flagellin-and-pilin-provide-effective-immunotherapy-against-pseudomonas-aeruginosa-infection-of-mice-with-burn-wounds
#12
Mahmood Saffari, Somayeh Behbood, Gholamreza Irajian, Ahmad Khorshidi, Rezvan Moniri, Bahador Behrouz
Burn wound infections caused by multidrug-resistant Pseudomonas aeruginosa strains are a serious challenge to therapy because of the complex pathogenesis and paucity of new effective antibiotics. Therefore, there is renewed interest in developing antibody-based therapeutic strategies. Immunotherapy strategies typically target selected virulence factors that are expressed by the majority of clinical strains of P. aeruginosa, particularly because virulence factors mediate infection. Here we used a murine model of burn wound infection to evaluate the efficacy of antibodies raised against the divalent type b flagellin and PilA (flagellin b + PilA), as acute virulence factors, to prevent and treat infection...
November 8, 2016: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/27819127/evaluation-of-the-antibacterial-activity-of-a-conventional-orthodontic-composite-containing-silver-hydroxyapatite-nanoparticles
#13
Ahmad Sodagar, Azam Akhavan, Ehsan Hashemi, Sepideh Arab, Maryam Pourhajibagher, Kosar Sodagar, Mohammad Javad Kharrazifard, Abbas Bahador
BACKGROUND: One of the most important complications of fixed orthodontic treatment is the formation of white spots which are initial carious lesions. Addition of antimicrobial agents into orthodontic adhesives might be a wise solution for prevention of white spot formation. The aim of this study was to evaluate the antibacterial properties of a conventional orthodontic adhesive containing three different concentrations of silver/hydroxyapatite nanoparticles. METHODS: One hundred and sixty-two Transbond XT composite discs containing 0, 1, 5, and 10 % silver/hydroxyapatite nanoparticles were prepared and sterilized...
December 2016: Progress in Orthodontics
https://www.readbyqxmd.com/read/27817080/retraction-note-to-tissue-expression-levels-of-mir-29b-and-mir-422a-in-children-adolescents-and-young-adults-age-groups-and-their-association-with-prediction-of-poor-prognosis-in-human-osteosarcoma
#14
Reza Bahador, Afshin Taheriazam, Alireza Mirghasemi, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi, Peyman Karimi Goudarzi
No abstract text is available yet for this article.
November 5, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27817078/retraction-note-to-downregulation-of-microrna-217-and-microrna-646-acts-as-potential-predictor-biomarkers-in-progression-metastasis-and-unfavorable-prognosis-of-human-osteosarcoma
#15
Afshin Taheri Azam, Reza Bahador, Hamid Hesarikia, Mohammadreza Shakeri, Ali Yeganeh
No abstract text is available yet for this article.
November 5, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27802812/retraction-note-down-regulation-of-microrna-26a-and-up-regulation-of-microrna-27a-contributes-to-aggressive-progression-of-human-osteosarcoma
#16
Afshin Taheriazam, Reza Bahador, Seyyed Hasan Karbasy, Seyed Mir Mansoor Moazen Jamshidi, Ali Torkaman, Emad Yahaghi, Mohammadreza Shakeri
No abstract text is available yet for this article.
November 2, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27800144/seroprevalence-and-molecular-evaluation-of-toxoplasmosis-in-patients-undergoing-chemotherapy-for-malignancies-in-the-bushehr-province-southwest-iran
#17
Afshin Barazesh, Bahador Sarkari, Farhad Mehrabi Sisakht, Samaneh Abdolahi Khabisi, Reza Nikbakht, Mohammad Reza Ravanbod
BACKGROUND: Toxoplasmosis is a life-threatening infection in organ transplant recipients, people receiving corticosteroid or radiation therapy, people with malignancies, and AIDS patients. OBJECTIVES: The current study aimed to determine the prevalence of toxoplasmosis in patients receiving chemotherapy for malignancies in the Bushehr province of southwest Iran. METHODS: Blood samples were taken from 86 patients who were continuously referred to the chemotherapy center in Bushehr province and evaluated by ELISA to determine anti-Toxoplasma IgG and IgM antibodies...
September 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27769914/the-efficacy-of-photodynamic-and-photothermal-therapy-on-biofilm-formation-of-streptococcus-mutans-an-in-vitro-study
#18
Leili Beytollahi, Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Reza Raoofian, Babak Pourakbari, Bahador Abbas
BACKGROUND: The alternative antibacterial treatments of photodynamic therapy (PDT) and photothermal therapy (PTT) significantly affect microbiota inactivation. The aim of the present research was the assessment of the antimicrobial and anti-biofilm effects of PDT with toluidine blue O (TBO) and PTT with indocyanine green (ICG) on Streptococcus mutans as a cariogenic bacterium. MATERIALS AND METHODS: The S. mutans ATCC 35668 strain was treated with final concentrations of 0...
October 18, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27744062/photo-activated-disinfection-based-on-indocyanine-green-against-cell-viability-and-biofilm-formation-of-porphyromonas-gingivalis
#19
Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Abbas Bahador
BACKGROUND: Photo-activated disinfection (PAD) is a novel treatment approach, in which bacteria in the root canal system may be exposed to sub-lethal doses of PAD. Such exposure can affect bacterial survival and virulence features, such as biofilm formation ability. The aim of this study was to evaluate the effects of sub-lethal doses of PAD (sPAD) using indocyanine green (ICG) on load and biofilm formation ability of Porphyromonas gingivalis as an anaerobic bacterium associated with endodontic infection...
October 12, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27697516/outer-membrane-protein-100-of-aggregatibacter-actinomycetemcomitans-act-as-a-biopharmaceutical-target-for-photodynamic-therapy-an-in-silico-analysis
#20
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Periodontitis is a polymicrobial, chronic, and degenerative disease that can lead to destruction of the teeth-supporting tissues and eventually to loss of teeth. Aggregatibacter actinomycetemcomitans is predominantly associated with periodontal diseases. Outer membrane protein (Omp) 100 is a more important virulence factor of A. actinomycetemcomitans due to the effect of adhesion and invasion into human gingival epithelial cells. Attachment of A. actinomycetemcomitans inhibition is significant in the treatment process...
December 2016: Photodiagnosis and Photodynamic Therapy
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