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Atahualpa Project

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https://www.readbyqxmd.com/read/27777377/severe-edentulism-is-a-major-risk-factor-influencing-stroke-incidence-in-rural-ecuador-the-atahualpa-project
#1
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Victor J Del Brutto
BACKGROUND: There is no information on stroke incidence in rural areas of Latin America, where living conditions and cardiovascular risk factors are different from urban centers. AIM: Using a population-based prospective cohort study design, we aimed to assess risk factors influencing stroke incidence in community-dwelling adults living in rural Ecuador. METHODS: First-ever strokes occurring from 1 June 2012 to 31 May 2016, in Atahualpa residents aged ≥40 years, were identified from yearly door-to-door surveys and other overlapping sources...
October 24, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27774585/the-importance-of-people-compliance-social-desirability-bias-in-the-assessment-of-epilepsy-prevalence-in-rural-areas-of-developing-countries-results-of-the-atahualpa-project
#2
Oscar H Del Brutto, Robertino M Mera
Epilepsy is a major health issue in rural areas of developing countries. However, heterogeneity of epilepsy prevalence in different studies precludes assessment of the magnitude of the problem. Using similar protocols, two population-based surveys were conducted 12 years apart (2003 and 2015) in a rural Ecuadorian village (Atahualpa). The only difference was a higher people compliance with interviewers during the second survey. Epilepsy prevalence in the 2003 survey was 13.5 per 1,000 (18/1,332) in villagers aged ≥20 years...
October 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/27718386/the-burden-of-diabetes-related-foot-disorders-in-community-dwellers-living-in-rural-ecuador-results-of-the-atahualpa-project
#3
Oscar H Del Brutto, Robertino M Mera, Nathan R King, Mauricio Zambrano, Lauren J Sullivan
BACKGROUND/OBJECTIVES: Prevalence of diabetes-related foot disorders (DRFD) in rural areas of developing countries is unknown. The burden of these conditions in Atahualpa, a rural Ecuadorian village, were assessed. METHODS: Using a population-based design, Atahualpa residents aged ≥40 years with diabetes mellitus were identified. Ankle brachial index determinations were used to assess presence of peripheral arterial disease, and the Michigan Neuropathy Screening Instrument was used to estimate peripheral neuropathy...
June 2, 2016: Foot
https://www.readbyqxmd.com/read/27529780/the-influence-of-age-in-the-relationship-between-cerebral-small-vessel-disease-and-edentulism-the-atahualpa-project
#4
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano
BACKGROUND: The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS: MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were classified in 2 groups according to whether they have severe edentulism (<10 remaining teeth) or not. Using multivariate logistic regression and exposure effect models, we assessed whether edentulism correlated with severity of white matter hyperintensities (WMHs), after adjusting for relevant confounders...
August 17, 2016: European Neurology
https://www.readbyqxmd.com/read/27423619/population-based-study-of-alcoholic-cerebellar-degeneration-the-atahualpa-project
#5
Oscar H Del Brutto, Robertino M Mera, Lauren J Sullivan, Mauricio Zambrano, Nathan R King
BACKGROUND: There are no population studies estimating the burden of alcoholic cerebellar degeneration (ACD). We aimed to assess prevalence and correlates of ACD among chronic alcohol drinkers living in rural Ecuador. METHODS: Characteristics of alcohol intake were evaluated in community-dwelling men aged ≥40years enrolled in the Atahualpa Project. Cerebellar dysfunction evaluation used the Brief Ataxia Rating Scale (BARS). Association between alcohol intake and the BARS was assessed in generalized linear models adjusted for relevant confounders...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27401268/calcifications-in-the-carotid-siphon-inversely-associate-with-cognitive-performance-in-stroke-free-community-dwellers-living-in-rural-ecuador-the-atahualpa-project
#6
Oscar H Del Brutto, Robertino M Mera, Lauren J Sullivan, Mauricio Zambrano, Nathan R King
We aimed to assess whether carotid siphon calcifications (as seen on computed tomography) are associated with worse performance in the Montreal Cognitive Assessment in 584 stroke-free individuals living in rural Ecuador. Using mean Montreal Cognitive Assessment score of subjects with Grade 1 calcifications (23.1 ± 4.2) as the referent category, fully adjusted generalized linear models showed significant associations between severity of carotid siphon calcifications and cognitive performance (mean Montreal Cognitive Assessment scores: 20...
July 11, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27232913/hypertensive-retinopathy-and-cerebral-small-vessel-disease-in-amerindians-living-in-rural-ecuador-the-atahualpa-project
#7
Oscar H Del Brutto, Robertino M Mera, Eduardo M Viteri, Joaquín Pólit, Ernesto A Ledesma, José A Cano, Karin J Plaza, Mauricio Zambrano, Aldo F Costa
BACKGROUND: Diagnosis of cerebral small vessel disease (SVD) is a challenge in remote areas where MRI is not available. Hypertensive retinopathy (HTRP) has shown to correlate with SVD in different ethnic groups, but there is no information from indigenous Latin American people. We assessed the usefulness of retinal photographs to detect cases with SVD among Amerindians living in rural Ecuador. METHODS: Atahualpa residents aged ≥60years with arterial hypertension or prehypertension were identified during a door-to-door survey...
September 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27217907/caffeine-intake-has-no-effect-on-sleep-quality-in-community-dwellers-living-in-a-rural-ecuadorian-village-the-atahualpa-project
#8
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
More information is needed to better understand the effect of caffeine on sleep quality at the community level. In a population-based, cross-sectional study design, we aimed to assess the effect of caffeine intake on sleep quality by the use of a multivariate exposure-effect model, adjusted for relevant confounders. All Atahualpa residents aged ≥40 years were identified during a door-to-door survey and interviewed with the Pittsburgh Sleep Quality Index (PSQI) and a structured instrument designed to estimate the daily amount of caffeine intake...
January 2016: Sleep Science
https://www.readbyqxmd.com/read/26990452/presence-of-cerebral-microbleeds-is-unrelated-to-the-body-mass-index-in-amerindians-a-population-study-in-rural-ecuador-the-atahualpa-project
#9
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Scheny Feraud
BACKGROUND: Information on the relationship between the presence of cerebral microbleeds (CMB) and the body weight is inconsistent. Moreover, studies have been limited to Asian and White populations. We aimed at assessing the association between CMB and the body mass index (BMI) in an indigenous South American population. METHODS: CMB were identified by gradient-echo MRI and the BMI was calculated in community dwellers aged ≥60 enrolled in the Atahualpa Project...
2016: European Neurology
https://www.readbyqxmd.com/read/26833914/the-bicaudate-index-inversely-associates-with-performance-in-the-montreal-cognitive-assessment-moca-in-older-adults-living-in-rural-ecuador-the-atahualpa-project
#10
Oscar H Del Brutto, Robertino M Mera, Victor J Del Brutto, Mark J Sedler
OBJECTIVE: Assessment of cognitive impairment in rural areas of developing countries is complicated by illiteracy and cross-cultural factors. A better way to estimate the usefulness of cognitive screening instruments is to evaluate their correlation with imaging biomarkers. The bicaudate index (a marker of central atrophy) correlates with cognitive performance. We assessed the relationship of the bicaudate index with the MoCA to estimate the usefulness of this test to detect individuals with cognitive decline in these regions...
August 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26832127/the-effect-of-age-in-the-association-between-frailty-and-poor-sleep-quality-a-population-based-study-in-community-dwellers-the-atahualpa-project
#11
Oscar H Del Brutto, Robertino M Mera, Mark J Sedler, Mauricio Zambrano, Johnathan L Nieves, Kristen Cagino, Kathryn D Fanning, Marleni F Milla-Martinez, Pablo R Castillo
PURPOSE: To assess the effect of age in the association between poor sleep quality and frailty status. DESIGN AND SETTING: Population-based, cross-sectional study conducted in Atahualpa, a rural village located in coastal Ecuador. METHODS: Out of 351 Atahualpa residents aged ≥ 60 years, 311 (89%) were interviewed with the Pittsburgh Sleep Quality Index (PSQI) and the Edmonton Frail Scale (EFS). The independent association between PSQI and EFS scores was evaluated by the use of a generalized linear model adjusted for relevant confounders...
March 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/26790541/neuroimaging-signatures-of-frailty-a-population-based-study-in-community-dwelling-older-adults-the-atahualpa-project
#12
Oscar H Del Brutto, Robertino M Mera, Kristen Cagino, Kathryn D Fanning, Marleni F Milla-Martinez, Johnathan L Nieves, Mauricio Zambrano, Mark J Sedler
AIMS: Frailty is a geriatric state of physical vulnerability that might be associated with cognitive decline in the absence of a concurrent neurodegenerative disorder. This assumes that neuroimaging studies are normal, but such examinations have rarely been considered for a frailty work-up. The present study identifies neuroimaging signatures in older adults interviewed with the Edmonton Frail Scale (EFS). METHODS: Community-dwellers aged ≥60 years enrolled in the Atahualpa Project were invited to undergo brain magnetic resonance imaging...
January 21, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/26545868/willis-ekbom-disease-is-not-associated-with-poor-cardiovascular-health-in-adults
#13
Brynn K Dredla, Oscar H Del Brutto, Augustine S Lee, Pablo R Castillo
BACKGROUND: Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovascular disease worldwide, we assessed the relation between WED/RLS and cardiovascular health risks in a native South American population. We prospectively analyzed data from The Atahualpa Project of Ecuadorian adults aged 40 years and older. Physicians interviewed consented persons on the health behavior and health factors of the American Heart Association (AHA) for ideal cardiovascular health in adults and underwent fasting laboratory blood collection and blood pressure evaluation...
2015: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26497828/oily-fish-consumption-is-inversely-correlated-with-cerebral-microbleeds-in-community-dwelling-older-adults-results-from-the-atahualpa-project
#14
Oscar H Del Brutto, Robertino M Mera, Jung-Eun Ha, Victor J Del Brutto, Pablo R Castillo, Mauricio Zambrano, Jennifer Gillman
BACKGROUND: Oily fish is a major dietary source of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). These nutrients improve endothelial dysfunction, reduce β-amyloid induced damage of neurovascular units, and might prevent the occurrence of cerebral microbleeds. However, this relationship has not been investigated so far. AIM: To evaluate the association between oily fish intake and cerebral microbleeds in a population of frequent fish consumers living in coastal Ecuador...
August 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/26426278/the-association-of-frailty-with-abnormal-ankle-brachial-index-determinations-is-related-to-age-results-from-the-atahualpa-project
#15
LETTER
Oscar H Del Brutto, Robertino M Mera, David L Brown, Johnathan L Nieves, Marleni F Milla-Martinez, Kathryn D Fanning, Kristen Cagino, Mauricio Zambrano, Mark J Sedler
No abstract text is available yet for this article.
January 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26318241/intracranial-arterial-stenosis-in-ecuadorian-natives-mestizos-a-population-based-study-in-older-adults-the-atahualpa-project
#16
Oscar H Del Brutto, Robertino M Mera, Julio Lama, Mauricio Zambrano, Victor J Del Brutto
BACKGROUND: Intracranial arterial stenosis (IAS) is more prevalent among Asians, Blacks and Caribbean Hispanics than in Whites. However, there is no information on the importance of this common cause of stroke among Mestizo/Native populations of Latin America. We aimed to assess prevalence and correlates of IAS in an indigenous Ecuadorian population of older adults. METHODS: Atahualpa residents aged ≥60 years were identified during door-to-door surveys and invited to undergo brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) of intracranial vessels for identification of stroke lesions and arterial stenosis...
November 2015: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/26310517/cerebrovascular-correlates-of-vitamin-d-deficiency-in-older-adults-living-near-the-equator-results-from-the-atahualpa-project
#17
Oscar H Del Brutto, Robertino M Mera, Jorge Macias, Gabriela Morales, Mauricio Zambrano
All studies attempting to find an association between vitamin D deficiency and cerebrovascular diseases have been conducted at latitudes far away from the Equator, where living conditions, cardiovascular risk factors, and sunshine exposure are different from tropical regions. We aimed to assess cerebrovascular correlates of vitamin D deficiency in community-dwelling older adults living in Atahualpa, a village located in rural coastal Ecuador. Out of 267 individuals enrolled in the neuroimaging substudy of the Atahualpa Project, 220 (82%) signed the informed consent...
December 2015: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26187093/oily-fish-intake-and-cognitive-performance-in-community-dwelling-older-adults-the-atahualpa-project
#18
Oscar H Del Brutto, Robertino M Mera, Jennifer Gillman, Mauricio Zambrano, Jung-eun Ha
Due to their high content of omega-3 polyunsaturated fatty acids, oily fish consumption is likely associated with a better cognitive performance. However, information on this association is controversial, with some studies showing a positive effect while others showing no association. We aimed to assess the effects of oily fish consumption on cognitive performance in a population of frequent fish consumers living in rural coastal Ecuador. Atahualpa residents aged ≥60 years were identified during a door-to-door survey and evaluated by the use of the Montreal Cognitive Assessment (MoCA)...
February 2016: Journal of Community Health
https://www.readbyqxmd.com/read/26178311/temporal-bone-thickness-and-texture-are-major-determinants-of-the-high-rate-of-insonation-failures-of-transcranial-doppler-in-amerindians-the-atahualpa-project
#19
Oscar H Del Brutto, Robertino M Mera, María de la Luz Andrade, Verónica Espinosa, Pablo R Castillo, Mauricio Zambrano, Juan A Nader
PURPOSE: To assess the role of temporal bone characteristics in transcranial Doppler (TCD) insonation failures in Amerindians living in rural Ecuador. METHODS: We evaluated thickness and texture of temporal bones in community-dwelling Amerindians ≥65 years old undergoing TCD. Using receiver operator characteristics curve analysis and generalized estimating equations, we investigated factors associated with insonation failures. RESULTS: Of 65 participants (mean age 74...
January 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/26022640/population-based-study-of-cerebral-microbleeds-in-stroke-free-older-adults-living-in-rural-ecuador-the-atahualpa-project
#20
Victor J Del Brutto, Mauricio Zambrano, Robertino M Mera, Oscar H Del Brutto
BACKGROUND AND PURPOSE: Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS: Of 311 Atahualpa residents aged ≥60 years identified during a door-to-door survey, 258 (83%) underwent brain magnetic resonance imaging. Twenty-one were further excluded for a diagnosis of overt stroke...
July 2015: Stroke; a Journal of Cerebral Circulation
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