keyword
MENU ▼
Read by QxMD icon Read
search

Toll like receptor 3 and cancer

keyword
https://www.readbyqxmd.com/read/29601492/obesity-inflammation-toll-like-receptor-4-and-fatty-acids
#1
REVIEW
Marcelo Macedo Rogero, Philip C Calder
Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic inflammatory response is an acute reaction to infections or to tissue injuries, and it tends to move towards resolution and homeostasis. However, the inflammatory process that was observed in individuals affected by obesity and metabolic syndrome differs from the classical inflammatory response in certain respects. This inflammatory process manifests itself systemically and it is characterized by a chronic low-intensity reaction...
March 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29596890/immuno-modulators-enhance-antigen-specific-immunity-and-anti-tumor-effects-of-mesothelin-specific-chimeric-dna-vaccine-through-promoting-dc-maturation
#2
Yu-Li Chen, Ming-Cheng Chang, Ying-Cheng Chiang, Han-Wei Lin, Nai-Yun Sun, Chi-An Chen, Wei-Zen Sun, Wen-Fang Cheng
As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine combined with anti-CD40 Ab and toll-like receptor 3 ligand-poly(I:C) were validated in an MSLN-expressing model. CTGF/MSLN DNA with anti-CD40Ab and poly(I:C) vaccinated mice demonstrated potent anti-tumor effects with longer survival and less tumor volumes...
March 26, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29556281/effect-of-tlr4-on-the-growth-of-siha-human-cervical-cancer-cells-via-the-myd88-traf6-tak1-and-nf-%C3%AE%C2%BAb-cyclin-d1-stat3-signaling-pathways
#3
Li Ma, Li Feng, Xiaoping Ding, Yongwang Li
The present study aimed to investigate the effect of Toll-like receptor 4 (TLR4) on SiHa human cervical cancer cells and its potential molecular biological mechanisms. The expression of TLR4 following treatment with lipopolysaccharide (LPS) in in SiHa cervical cancer cells was detected by quantitative polymerase chain reaction (qPCR). LPS-induced cell proliferation and apoptosis were detected by MTT assay as well as staining with propidium iodide (PI) and Annexin V/PI double staining. qPCR was performed to analyze the expression levels of tumor necrosis factor receptor-associated factor 6 (TRAF6) and transforming growth factor-activated kinase 1 (TAK1) genes...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29552131/integrated-analysis-of-microarray-data-to-identify-the-genes-critical-for-the-rupture-of-intracranial-aneurysm
#4
Liang Wei, Qi Wang, Yanfei Zhang, Cheng Yang, Hongxin Guan, Jianxin Jiang, Zhiyang Sun
Intracranial aneurysm (IA) is a localized dilation of the blood vessel. The present study was designed to explore the mechanisms of rupture of IA. GSE13353 (including 11 ruptured and 8 unruptured IA samples) and GSE15629 (including 8 ruptured and 6 unruptured IA samples) were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) identified using limma and MetaDE packages were merged, and a protein-protein interaction (PPI) network analysis was performed using Cytoscape software...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29530012/sepsis-increases-perioperative-metastases-in-a-murine-model
#5
Lee-Hwa Tai, Abhirami A Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A Kennedy, Rebecca C Auer
BACKGROUND: Cancer surgery can promote tumour metastases and worsen prognosis, however, the effect of perioperative complications on metastatic disease remains unclear. In this study we sought to evaluate the effect of common perioperative complications including perioperative blood loss, hypothermia, and sepsis on tumour metastases in a murine model. METHODS: Prior to surgery, pulmonary metastases were established by intravenous challenge of CT26LacZ colon cancer cells in BALB/c mice...
March 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29523766/nucleoside-diphosphate-kinase-3-nme3-enhances-tlr5-induced-nf-%C3%AE%C2%BAb-activation
#6
Kelly Flentie, Caleb Gonzalez, Brandon Kocher, Yue Wang, Hongtu Zhu, Jayne Marasa, David Piwnica-Worms
Bacterial flagellin is a potent activator of NF-κB signaling, inflammation and host innate immunity, and recent data indicate that flagellin represents a novel anti-tumor ligand acting through toll-like receptor 5 (TLR5) and the NF-κB pathway to induce host immunity and aid in the clearance of tumor xenografts. To identify innate signaling components of TLR5 responsible for these anti-tumor effects, a loss-of-function high-throughput screen was employed utilizing carcinoma cells expressing a dynamic NF-κB bioluminescent reporter stimulated by Salmonella typhimurium expressing flagellin...
March 9, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29511031/effect-of-perioperative-opioids-on-cancer-relevant-circulating-parameters-mu-opioid-receptor-and-tlr4-activation-potential-and-proteolytic-profile
#7
Nan Xie, Nicholas Matigian, Tharindu D Vithanage, Kye Gregory, Zeyad D Nassar, Peter J Cabot, Paul Nicholas Shaw, Carl Mj Kirkpatrick, Kim-Anh Lê Cao, David Sturgess, Marie-Odile Parat
PURPOSE: To investigate the potential interplay between opioid analgesia and tumour metastasis through modulation of μ opioid receptor (MOR), Toll-like receptor 4 (TLR4) activation, and matrix degradation potential. EXPERIMENTAL DESIGN: Plasma samples were collected from 60 patients undergoing elective lower limb joint replacement pre-operatively and at 3, 6 and 24 h after surgery; pain scores were documented at the same time points. Opioid administration was recorded and converted into morphine IV equivalents...
March 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29486738/compound-a-attenuates-toll-like-receptor-4-mediated-paclitaxel-resistance-in-breast-cancer-and-melanoma-through-suppression-of-il-8
#8
Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-Thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee, Chanitra Thuwajit
BACKGROUND: Paclitaxel (PTX) is a potent anti-cancer drug commonly used for the treatment of advanced breast cancer (BCA) and melanoma. Toll-like receptor 4 (TLR4) promotes the production of pro-inflammatory cytokines associated with cancer chemoresistance. This study aims to explore the effect of TLR4 in PTX resistance in triple-negative BCA and advanced melanoma and the effect of compound A (CpdA) to attenuate this resistance. METHODS: BCA and melanoma cell lines were checked for the response to PTX by cytotoxic assay...
February 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#9
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29371911/tlr-signaling-inhibitor-phenylmethimazole-in-combination-with-tamoxifen-inhibits-human-breast-cancer-cell-viability-and-migration
#10
Anthony L Schwartz, Eric Dickerson, Nilesh Dagia, Ramiro Malgor, Kelly D McCall
Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral component of solid tumors and hematological malignancies. Our previous findings in pancreatic cancer and melanoma suggest that inhibition of these pathways by a TLR3 signaling inhibitor, phenylmethimazole (C10), results in significantly decreased IL-6 levels, STAT3 phosphorylation, minimal cancer cell migration and reduced cancer cell growth in vitro and in vivo. In this study, we extended our earlier observations by performing studies in human breast cancer cells...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29355463/effects-of-radiation-response-modifiers-given-after-lethal-whole-abdominal-irradiation
#11
Eng-Yen Huang, Chen-Tzu Peng, Chung-Chih Wang
PURPOSE: Although radiation is used to treat cancer and generate electricity, radiotherapy-induced complications and nuclear disasters are issues of great concern. The small bowel and bone marrow are the two major organs injured by radiation, especially that from nuclear disasters. The development of effective drugs to alleviate radiation injuries is very important. We tested potential radiation response modifiers given after irradiation to alleviate radiation injuries and mortality. MATERIALS AND METHODS: Xenografts of C33A tumor cells with or without galectin-1 expression were implanted in SCID mice...
March 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29342159/prediction-of-novel-target-genes-and-pathways-involved-in-bevacizumab-resistant-colorectal-cancer
#12
Precious Takondwa Makondi, Chia-Hwa Lee, Chien-Yu Huang, Chi-Ming Chu, Yu-Jia Chang, Po-Li Wei
Bevacizumab combined with cytotoxic chemotherapy is the backbone of metastatic colorectal cancer (mCRC) therapy; however, its treatment efficacy is hampered by therapeutic resistance. Therefore, understanding the mechanisms underlying bevacizumab resistance is crucial to increasing the therapeutic efficacy of bevacizumab. The Gene Expression Omnibus (GEO) database (dataset, GSE86525) was used to identify the key genes and pathways involved in bevacizumab-resistant mCRC. The GEO2R web tool was used to identify differentially expressed genes (DEGs)...
2018: PloS One
https://www.readbyqxmd.com/read/29206292/microrna-6869-5p-acts-as-a-tumor-suppressor-via-targeting-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-in-colorectal-cancer
#13
Shushan Yan, Zengfang Wang, Quanhong Duan, Changcheng Wang, Donghua Xu
Many studies have implicated that microRNAs (miRNAs), as non-coding RNAs, play important roles in the development and progression of colorectal cancer (CRC). However, little is known about the role of a newly identified miRNA, miR-6869-5p, in CRC. We aim to investigate the modifying effects and underlying mechanisms of miR-6869-5 in colorectal carcinogenesis and progression. Significantly reduced levels of miR-6869-5p were observed in both serum exosomes tumor tissue samples from patients with CRC. The prediction of targets of miR-6869-5p in databases of targetscan, microRNA...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29196874/upregulation-of-spinal-voltage-dependent-anion-channel-1-contributes-to-bone-cancer-pain-hypersensitivity-in-rats
#14
Xiangpeng Kong, Jinrong Wei, Diyu Wang, Xiaoju Zhu, Youlang Zhou, Shusheng Wang, Guang-Yin Xu, Guo-Qin Jiang
Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4 (TLR4)...
December 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29190881/toll-like-receptor-expression-in-human-non-small-cell-lung-carcinoma-potential-prognostic-indicators-of-disease
#15
Alison K Bauer, Brad L Upham, Elizabeth A Rondini, Meredith A Tennis, Kalpana Velmuragan, David Wiese
Introduction: Lung cancer remains the highest cause of cancer mortality worldwide. Toll-like receptors (TLR) are innate immune receptors that have both pro- and anti-tumorigenic properties. Based on findings from epidemiological studies and in rodents, we hypothesized that elevated TLR expression would be a positive prognostic indicator of disease in non-small cell lung carcinoma patients. Results: Higher mRNA expression of TLR1-3 and 5-8 were significantly associated with increased overall survival (OS) when analyzed individually or as a group in both non-small cell lung carcinoma (NSCLC) patients and in the adenocarcinoma (ADC) subtype...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29138827/gambogic-acid-inhibits-spinal-cord-injury-and-inflammation-through-suppressing-the-p38-and-akt-signaling-pathways
#16
Qiao Fu, Chaojian Li, Lehua Yu
Gamboge is the dry resin secreted by Garcinia hanburyi Hook.f, with the function of promoting blood circulation, detoxification, hemostasis and killing insects, used for the treatment of cancer, brain edema and other diseases. Gambogic acid is the main effective constituent of Gamboge. The present study investigated the protective effects of gambogic acid on spinal cord injury (SCI) and its anti‑inflammatory mechanism in an SCI model in vivo. Basso, Beattie and Bresnahan (BBB) testing was used to detect the protective effects of gambogic acid on nerve function of SCI rats...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29104459/effects-of-oral-glutamine-on-inflammatory-and-autophagy-responses-in-cancer-patients-treated-with-abdominal-radiotherapy-a-pilot-randomized-trial
#17
Juan J Ortiz de Urbina, Beatriz San-Miguel, Alfonso Vidal-Casariego, Irene Crespo, Diana I Sánchez, José L Mauriz, Jesús M Culebras, Javier González-Gallego, María J Tuñón
Background and Aims: Abdominal radiotherapy (RT) causes harm to the mid gastrointestinal mucosa by release of pro-inflammatory cytokines and promotes autophagic changes in tumor cells. This study was aimed to measure the effect of glutamine administration on markers of inflammation and autophagy in cancer patients treated with RT. Methods: In this double-blind, randomized, controlled pilot trial 43 patients under abdominal RT diagnosed of pelvic or abdominal malignancies receiving glutamine (30 g/d) or placebo (casein, 30 g/d)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28991224/resistin-facilitates-breast-cancer-progression-via-tlr4-mediated-induction-of-mesenchymal-phenotypes-and-stemness-properties
#18
C-H Wang, P-J Wang, Y-C Hsieh, S Lo, Y-C Lee, Y-C Chen, C-H Tsai, W-C Chiu, S Chu-Sung Hu, C-W Lu, Y-F Yang, C-C Chiu, F Ou-Yang, Y-M Wang, M-F Hou, S-Sf Yuan
Growing evidence indicates that resistin-an obesity-related cytokine-is upregulated in breast cancer patients, yet its impact on breast cancer behavior remains to be ascertained. Similarly, Toll-like receptor 4 (TLR4) has been implicated in breast cancer progression, however, its clinically relevant endogenous ligand remains elusive. In this study, we observed that high serum resistin levels in breast cancer patients positively correlated with tumor stage, size and lymph node metastasis. These findings were replicated in animal models of breast cancer tumorigenesis and metastasis...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28980060/phase-i-study-of-a-chloroquine-gemcitabine-combination-in-patients-with-metastatic-or-unresectable-pancreatic-cancer
#19
Panagiotis Samaras, Marina Tusup, Thi Dan Linh Nguyen-Kim, Burkhardt Seifert, Helga Bachmann, Roger von Moos, Alexander Knuth, Steve Pascolo
PURPOSE: Following a previously published pre-clinical validation, this phase I study evaluated the safety, maximum tolerated dose, anti-tumour activity and immune status of a gemcitabine-chloroquine combination as a first- or late-line treatment in patients with metastatic or unresectable pancreatic cancer. METHODS: In this 3 + 3 dose escalation study, patients received a single weekly standard dose of intravenous gemcitabine, followed by single weekly oral intake of 100, 200 or 300 mg of chloroquine...
November 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28950845/ethanol-extract-of-propolis-and-its-constituent-caffeic-acid-phenethyl-ester-inhibit-breast-cancer-cells-proliferation-in-inflammatory-microenvironment-by-inhibiting-tlr4-signal-pathway-and-inducing-apoptosis-and-autophagy
#20
Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu, Hongzhuan Xuan
BACKGROUND: Propolis and its major constituent - caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in inflammatory microenvironment, and inflammatory responses play decisive roles at different stages of tumor development. To understand the effects and mechanisms of ethanol-extracted Chinese propolis (EECP) and its major constituent - CAPE in inflammation-stimulated tumor, we investigated their effects on Toll-like receptor 4 (TLR4) signaling pathway which plays a crucial role in breast cancer MDA-MB-231 cell line...
September 26, 2017: BMC Complementary and Alternative Medicine
keyword
keyword
85426
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"