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contrasted induced nephropathy

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https://www.readbyqxmd.com/read/29432373/contrast-induced-nephropathy-in-stemi-patients-with-and-without-chronic-kidney-disease
#1
Tarun Jain, Sunay Shah, Jainil Shah, Gordon Jacobsen, Akshay Khandelwal
INTRODUCTION: Contrast-induced nephropathy (CIN) following percutaneous coronary intervention (PCI) is associated with adverse outcomes; however, there are scarce data comparing clinical outcomes of post-PCI CIN in ST elevation myocardial infarction (STEMI) patients with and without chronic kidney disease (CKD). We sought to assess the incidence, clinical predictors, and short-term and long-term clinical outcomes of post-PCI CIN in STEMI patients with and without CKD. METHODS: We performed a retrospective observational cohort study involving 554 patients who underwent PCI for STEMI from February 2010 to November 2013...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29425536/magnetic-iodixanol-%C3%A2-a-novel-contrast-agent-and-its-early-characterization
#2
M C Arokiaraj, E Menesson, N Feltin
AIMS: Contrast-induced nephropathy is a commonly encountered problem in clinical practice. The purpose of the study was to design and develop a novel contrast agent, which could be used to prevent contrast-induced nephropathy in the future. METHODS: In total, 20-220nm magnetic nanoparticles were conjugated with iodixanol, and their radio-opacity and magnetic properties were assessed thereafter. Scanning electron microscopy pictures were acquired. Thereafter, the nanoparticles conjugate was tested in cell culture (HUVEC cells), and Quantibody® assay was studied after cell treatment in 1:5 dilutions for 48h, compared with control...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29411334/regulation-and-bioactivity-of-the-ccn-family-of-genes-and-proteins-in-obesity-and-diabetes
#3
REVIEW
Stephen M Twigg
Across the years the CCNs have been increasingly implicated in the development of obesity, diabetes and its complications. Evidence for this is currently derived from their dysregulation in key metabolic pathological states in humans, animal and in vitro models, and also pre-clinical effects of their bioactivities. CCN2 is the best studied in this disease process and the other CCNs are yet to be better defined. Key steps where CCNs may play a pathogenic metabolic role include: (i) obesity and insulin resistance, where CCN2 inhibits fat cell differentiation in vitro and CCN3 may induce obesity and insulin resistance; (ii) elevated blood glucose levels to diabetes mellitus onset, where CCN2 may contribute to pancreatic beta cell and islet function; and (iii) in diabetes complications, such as nephropathy, retinopathy, liver disease (NAFLD/NASH), CVD and diabetes with heart failure...
February 6, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29404930/comparative-efficacy-of-pharmacological-interventions-for-contrast-induced-nephropathy-prevention-after-coronary-angiography-a-network-meta-analysis-from-randomized-trials
#4
REVIEW
Wen-Qi Ma, Yu Zhao, Ying Wang, Xi-Qiong Han, Yi Zhu, Nai-Feng Liu
BACKGROUND: Contrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta-analysis to evaluate the relative efficacy of pharmacological interventions for the prevention of CIN. METHODS: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials...
February 5, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29402790/unravelling-pathophysiology-of-crystalline-nephropathy-in-ceftriaxone-associated-acute-kidney-injury-a-cellular-proteomic-approach
#5
Supawat Chatchen, Nutkridta Pongsakul, Chantragan Srisomsap, Wararat Chiangjong, Suradej Hongeng, Jisnuson Svasti, Somchai Chutipongtanate
BACKGROUND: Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS: Ceftriaxone was crystallized with calcium in artificial urine. Madin-Darby Canine Kidney (MDCK) cells, a model of distal renal tubular cell, were cultured in the absence (untreated control) or presence of ceftriaxone crystals for 48-h (n = 5 each)...
January 16, 2018: Nephron
https://www.readbyqxmd.com/read/29393219/ultra-low-contrast-volume-for-patients-with-advanced-chronic-kidney-disease-undergoing-coronary-procedures
#6
Zach Rozenbaum, Sydney Benchetrit, Eliezer Rozenbaum, Eran Neumark, Morris Mosseri, David Pereg
BACKGROUND/AIMS: Contrast induced nephropathy (CIN) is associated with adverse clinical outcomes in patients undergoing coronary interventions, particularly in patients with advanced chronic kidney. The study was aimed to assess the real-life feasibility and safety of ultra-low volume coronary procedures in patients with advanced chronic kidney disease. METHODS: A prospective study that included patients with an estimated glomerular filtration rate (eGFR) <45 mL/min/1...
January 24, 2018: Nephron
https://www.readbyqxmd.com/read/29390867/the-incidence-risk-factors-and-outcomes-of-contrast-induced-nephropathy-in-patients-with-critical-limb-ischemia-following-lower-limb-angiography
#7
Marcus Vinícius Martins Cury, Marcelo Fernando Matielo, Francisco Cardoso Brochado Neto, Rafael de Athayde Soares, Vinícius Lopes Adami, Jalíese Dantas Fernandes Morais, Aline Yoshimi Futigami, Roberto Sacilotto
Intra-arterial digital subtraction angiography (DSA) is commonly used for the diagnosis and treatment of patients with critical limb ischemia (CLI). The aim of this study was to analyze the incidence of contrast-induced nephropathy (CIN) in patients with CLI and to assess their outcomes. Between May 2013 and May 2014, a prospective and observational study was conducted with 107 patients admitted exclusively for CLI treatment. The main outcomes included hemodialysis independence (HI) and overall survival (OS), as assessed by Kaplan-Meier curves...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29387419/predicting-contrast-induced-nephropathy-after-ct-pulmonary-angiography-in-the-critically-ill-a-retrospective-cohort-study
#8
Kwok M Ho, Yusrah Harahsheh
Background: It is uncertain whether we can predict contrast-induced nephropathy (CIN) after CT pulmonary angiography (CTPA). This study compared the ability of a validated CIN prediction score with the Pulmonary Embolism Severity Index (PESI) in predicting CIN after CTPA. Methods: This cohort study involved critically ill adult patients who required a CTPA to exclude acute pulmonary embolism (PE). Patients with end-stage renal failure requiring dialysis were excluded...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29373222/predicting-contrast-induced-nephropathy-after-percutaneous-coronary-intervention-do-we-need-formulas-a-cardiological-perspective
#9
Marinella Patrizia Centemero, Amnda G M R Sousa
No abstract text is available yet for this article.
January 17, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29371869/allopurinol-prophylactic-therapy-and-the-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-coronary-angiography-a-prospective-randomized-controlled-trial
#10
Leili Iranirad, Mohammad Saleh Sadeghi, Ahmadreza Bagheri, Kobra Doostali, Samieh Norouzi, Seyed Fakhreddin Hejazi, Hossein Saghafi, Sakineh Roshani-Mobaraki
BACKGROUND: Contrast-induced nephropathy (CIN) is considered to be a possibly severe complication of radiography and thus, remains to be the main cause of acute kidney injury (AKI) for inpatients. A clinical trial was executed to measure the preventive effect of allopurinol against CIN in high-risk patients undertaking coronary angiography. METHODS: Through randomized controlled trial, 140 patients with at minimum two risk factors of CIN, undertaking coronary angiography, were randomly allocated to the allopurinol (n = 70) or control group (n = 70)...
September 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29352692/ckd-epi-versus-cockcroft-gault-formula-for-predicting-contrast-induced-nephropathy-following-percutaneous-coronary-intervention-in-patients-without-significant-renal-impairment
#11
Mário B G Nunes, Antônio C Filho, Valéria R C Alvares, Rafael Moreno, Edgar Lamas, Vitor Loures, Daniel Chamié, Alexandre Abizaid
INTRODUCTION: Individuals with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 estimated by the Cockcroft-Gault formula (CG) who undergo percutaneous coronary intervention (PCI) frequently develop contrast-induced nephropathy (CIN). This study aimed to assess whether individuals with significant renal impairment assessed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, but not by CG, more often develop CIN following PCI than those without renal impairment by either formula...
January 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29346126/complete-revascularization-for-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-artery-disease-a-meta-analysis-of-randomized-trials
#12
Gani Bajraktari, Haki Jashari, Pranvera Ibrahimi, Fernando Alfonso, Fisnik Jashari, Gjin Ndrepepa, Shpend Elezi, Michael Y Henein
INTRODUCTION: Despite the recent findings in randomized clinical trials (RCTs) with limited sample sizes and the updates in clinical guidelines, the current available data for the complete revascularization (CR) in hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) at the time of primary percutaneous coronary intervention (PCI) are still contradictory. AIM: The aim of this meta-analysis of the existing RCTs was to assess the efficacy of the CR versus revascularization of infarct-related artery (IRA) only during primary PCI in patients with STEMI and multivessel disease (MVD)...
January 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29343076/high-loading-dose-of-atorvastatin-for-the-prevention-of-serum-creatinine-and-cystatin-c-based-contrast-induced-nephropathy-following-percutaneous-coronary-intervention
#13
Naikuan Fu, Min Liang, Shicheng Yang
The aim of this study is to assess the efficacy of high-dose atorvastatin on the prevention of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention and observe the incidence of cystatin C (CyC)-based CIN. A total of 496 patients with ACS were randomly assigned to either the control group (247 patients receiving conventional dose atorvastatin 10 mg daily from 1 day before to 3 days after contrast administration) or the high-dose atorvastatin group (249 patients receiving atorvastatin 40 mg daily for the same perioperative period)...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29340699/long-term-expression-of-glomerular-genes-in-diabetic-nephropathy
#14
Dominik Chittka, Bernhard Banas, Laura Lennartz, Franz Josef Putz, Kathrin Eidenschink, Sebastian Beck, Thomas Stempfl, Christoph Moehle, Simone Reichelt-Wurm, Miriam C Banas
Background: Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease in western societies, its pathogenesis still remains largely unclear. A different gene pattern of diabetic and healthy kidney cells is one of the probable explanations. Numerous signalling pathways have emerged as important pathophysiological mechanisms for diabetes-induced renal injury. Methods: Glomerular cells, as podocytes or mesangial cells, are predominantly involved in the development of diabetic renal lesions...
January 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29340315/contrast-induced-nephropathy-and-oxygen-pretreatment-in-patients-with-impaired-renal-function
#15
Haruki Sekiguchi, Yoichi Ajiro, Yoshie Uchida, Kentaro Jujo, Kazunori Iwade, Naohide Tanaka, Ken Shimamoto, Yukio Tsurumi, Masatoshi Kawana, Nobuhisa Hagiwara
Introduction: Contrast-induced nephropathy is a complication following coronary angiography and percutaneous coronary intervention. Because contrast-induced nephropathy is a predictor of long-term mortality in patients with ischemic heart disease undergoing percutaneous coronary intervention, preventive strategies are required. We assessed the effects of periprocedural oxygenation on contrast-induced nephropathy among patients with pre-existing renal dysfunction. Methods: A total of 200 consecutive patients with impaired renal function (estimated glomerular filtration < 60 ml/min per 1...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29340080/inhibition-of-tumor-necrosis-factor-signaling-attenuates-renal-immune-cell-infiltration-in-experimental-membranous-nephropathy
#16
Yen-Sung Huang, Shin-Huei Fu, Kuo-Cheng Lu, Jin-Shuen Chen, Hsin-Yi Hsieh, Huey-Kang Sytwu, Chia-Chao Wu
Idiopathic membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis and the most common cause of idiopathic nephrotic syndrome in adult humans. A tumor necrosis factor α (TNF-α)-mediated inflammatory response via TNF receptor 1 (TNFR1) and TNFR2 has been proposed as a pathogenic factor. In this study, we assessed the therapeutic response to blocking TNF signaling in experimental MN. Murine MN was induced experimentally by cationic bovine serum albumin (cBSA); phosphate-buffered saline was used in control mice...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29337451/-nephrology
#17
Sophie De Seigneux, Belen Ponte, Karine Hadaya, Yassine Bouatou, Patrick Saudan
New antidiabetic drugs which slow effectively the course of diabetic nephropathy are now available. There is no benefit of prophylactic hydratation to prevent contrast nephropathy in patients with moderate chronic kidney disease. In elderly hemodialysis patients, hemodiafiltration seems better tolerated than conventional hemodialysis, although there is a similar dialysis-induced myocardial stress with both methods. Role of de novo donor-specific antibodies is better characterized, which may subsequently lead to new treatments of graft rejection...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29331502/contrast-induced-nephropathy-an-entity-to-bear-in-mind-and-to-prevent-a-nephrological-perspective
#18
Rui Alves
No abstract text is available yet for this article.
January 10, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29328017/-hydration-to-prevent-contrast-induced-nephropathy
#19
E J Hoorn, R Zietse
In 2007, a national guideline was issued in the Netherlands to prevent contrast-induced nephropathy. This guideline recommended preventive hydration with 0.9% NaCl in patients with reduced estimated glomerular filtration rate (eGFR 30-69 ml/min/1.73 m2) prior to administration of contrast. The recent AMACING study compared hydration versus no hydration, and found that hydration did not prevent contrast-induced nephropathy but did lead to complications and higher costs. The latest 2017 guideline recommends hydration only for patients with eGFR < 30 ml/min/1...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29328007/-prophylactic-hydration-to-protect-renal-function-from-intravascular-iodinated-contrast-material-in-patients-at-high-risk-of-contrast-induced-nephropathy-amacing-a-prospective-randomised-phase-3-controlled-open-label-non-inferiority-trial
#20
E C Nijssen, R J Rennenberg, P J Nelemans, B A Essers, M M Janssen, M A Vermeeren, V van Ommen, J E Wildberger
BACKGROUND: Intravenous saline is recommended in clinical practice guidelines as the cornerstone for preventing contrast-induced nephropathy in patients with compromised renal function. However, clinical-effectiveness and cost-effectiveness of this prophylactic hydration treatment in protecting renal function has not been adequately studied in the population targeted by the guidelines, against a group receiving no prophylaxis. This was the aim of the AMACING trial. METHODS: AMACING is a prospective, randomised, phase 3, parallel-group, open-label, non-inferiority trial of patients at risk of contrast-induced nephropathy according to current guidelines...
2018: Nederlands Tijdschrift Voor Geneeskunde
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