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https://www.readbyqxmd.com/read/28213776/the-importance-of-drug-induced-sedation-endoscopy-d-i-s-e-techniques-in-surgical-decision-making-conventional-versus-target-controlled-infusion-techniques-a-prospective-randomized-controlled-study-and-a-retrospective-surgical-outcomes-analysis
#1
Andrea De Vito, Vanni Agnoletti, Gianluca Zani, Ruggero Massimo Corso, Giovanni D'Agostino, Elisabetta Firinu, Chiara Marchi, Ying-Shuo Hsu, Stefano Maitan, Claudio Vicini
Drug-Induced Sedation Endoscopy (DISE) consists of the direct observation of the upper airways during sedative-induced sleep, allowing the identification of the sites of pharyngeal collapse, which is the main pathological event in Obstructive Sleep Apnea (OSA). The Authors have compared Target Controlled Infusion (TCI) sedation endoscopy (TCI-DISE) technique to conventional DISE (CDISE), performed by a manual bolus injection of sedative agent, to recreate accurately and safely snoring and apnea patterns comparable to natural sleep...
February 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28212893/traffic-related-air-pollution-impact-on-mouse-brain-accelerates-myelin-and-neuritic-aging-changes-with-specificity-for-ca1-neurons
#2
Nicholas C Woodward, Payam Pakbin, Arian Saffari, Farimah Shirmohammadi, Amin Haghani, Constantinos Sioutas, Mafalda Cacciottolo, Todd E Morgan, Caleb E Finch
Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM2.5). Rodents exposed to TRAP have shown microglial activation and neuronal atrophy. We further investigated age differences of TRAP exposure, with focus on hippocampus for neuritic atrophy, white matter degeneration, and microglial activation. Young- and middle-aged mice (3 and 18 months female C57BL/6J) were exposed to nanoscale-PM (nPM, <0...
January 13, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28211673/capillary-microfluidics-assembled-virus-like-particle-bio-nano-receptor-interfaces-for-label-free-biosensing
#3
Faheng Zang, Konstantinos Gerasopoulos, Adam D Brown, James N Culver, Reza Ghodssi
In this paper, a capillary microfluidics-integrated sensor system is developed for rapid assembly of bionanoreceptor interfaces on-chip and label-free biosensing. Genetically engineered Tobacco mosaic virus (TMV) virus-like particle (VLP), displaying thousands copies of identical receptor peptides FLAG-tags, are utilized as nanoceptors for antibody sensing. Controlled and accelerated assembly of VLP receptor layer on impedance sensor has been achieved using capillary effect and surface evaporation from an open-channel capillary microfluidic system...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28208759/acute-effects-of-particulate-air-pollution-on-ischemic-heart-disease-hospitalizations-in-shanghai-china
#4
Anyang Xu, Zhe Mu, Bo Jiang, Wei Wang, Han Yu, Lijuan Zhang, Jue Li
Background: Air pollution has been demonstrated to be a major risk factor for the development of cardiovascular and respiratory diseases worldwide. This study examines the relationship between the exposure to fine particulate matter (PM) and patient hospitalizations as a result of ischemic heart disease (IHD) during 2013-2014 in Shanghai, China. Methods: Daily IHD hospitalization data were acquired from the Shanghai Health Insurance Bureau (SHIB) from 1 January 2013 to 21 December 2014. Daily average concentrations of air pollution as well as meteorological data were obtained from the database of Shanghai Environmental Monitoring Center (SEMC) during the same time period, and all data were analyzed using standard epidemiological methodology...
February 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28204963/peritoneal-metastases-from-gastroenteropancreatic-neuroendocrine-tumors-incidence-risk-factors-and-prognosis
#5
Ariana Madani, Irene Thomassen, Yvette R B M van Gestel, Jarmila D W van der Bilt, Harm R Haak, Ignace H J T de Hingh, Valery E P P Lemmens
BACKGROUND: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare neoplasms and data on peritoneal metastases (PM) from these tumors are scarce. OBJECTIVE: The aim of this study was to present population-based data on the incidence, risk factors, and survival of synchronous PM in GEP-NETs. METHODS: Data from all patients diagnosed with a GEP-NET during 2007-2013 were collected from the Netherlands Cancer Registry. Age-standardized incidence rates were calculated and risk factors for developing PM were determined using multivariable logistic regression analysis...
February 15, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28203212/influence-of-ongoing-task-difficulty-and-motivation-level-on-children-s-prospective-memory-in-a-chinese-sample
#6
Pi-Guo Han, Lei Han, Yu-Long Bian, Yu Tian, Min-Xia Xu, Feng-Qiang Gao
Prospective memory (PM) is the process associated with the task of realizing delayed intentions in the future. Researchers distinguish two types of PM, namely time-based PM (tbPM) and event-based PM (ebPM). Experiment 1 investigated the developmental trajectory of 3- to 5-year-old preschool children's PM ability, and the occurrence of delayed retrieval (children execute the PM task in a larger window of opportunity) in both tbPM and ebPM tasks. Results revealed that the 5-year-old children outperformed the 3- and 4-year-old children in PM...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28202997/-a-novel-tissue-engineered-bone-constructed-by-using-human-adipose-derived-stem-cells-and-biomimetic-calcium-phosphate-scaffold-coprecipitated-with-bone-morphogenetic-protein-2
#7
W R Jiang, X Zhang, Y S Liu, G Wu, Y J Ge, Y S Zhou
OBJECTIVE: To construct a novel biomimetic calcium phosphate (BioCaP) scaffold loaded with bone morphogenetic protein-2 (BMP-2), and to investigate its role in the osteogenesis of human adipose-derived stem cells (hASCs) in vitro and in vivo. METHODS: The BioCaP scaffold coprecipitated with BMP-2 (BMP-2-BioCaP) was constructed in this study. Field emission scanning electron microscopy (SEM) was used to analyze the morphology of the surfaces. The release kinetics was measured to evaluate the slow-release characteristics in vitro...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199353/oral-administration-of-lactobacillus-paracasei-l9-attenuates-pm2-5-induced-enhancement-of-airway-hyperresponsiveness-and-allergic-airway-response-in-murine-model-of-asthma
#8
Xifan Wang, Yan Hui, Liang Zhao, Yanling Hao, Huiyuan Guo, Fazheng Ren
This study investigated allergy immunotherapy potential of Lactobacillus paracasei L9 to prevent or mitigate the particulate matter 2.5 (PM2.5) enhanced pre-existing asthma in mice. Firstly, we used a mouse model of asthma (a 21-day ovalbumin (OVA) sensitization and challenge model) followed by PM2.5 exposure twice on the same day of the last challenge. PM2.5 was collected from the urban area of Beijing and underwent analysis for metals and polycyclic aromatic hydrocarbon contents. The results showed that PM2...
2017: PloS One
https://www.readbyqxmd.com/read/28192841/6-year-results-of-cnv-secondary-to-pathological-myopia-treated-with-ranibizumab
#9
L Hefner, H Gerding
Background The current standard treatment of choroidal neovascularisation (CNV) secondary to pathological myopia (PM) is intravitreal injection of VEGF antagonists. We now present our 6-year results after treating patients with CNV secondary to PM with ranibizumab. Patients and Methods We retrospectively analysed 15 treatment-naive eyes of 13 patients (10 women, 3 men, mean age 59.2; standard deviation (SD) 11.1; range 41-78 years) with visual impairment related to CNV secondary to PM, who were treated with at least 1 injection of ranibizumab...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28192748/exposure-to-pm2-5-induces-aberrant-activation-of-nf-%C3%AE%C2%BAb-in-human-airway-epithelial-cells-by-downregulating-mir-331-expression
#10
Lei Song, Dan Li, Xiaoping Li, Lianjun Ma, Xiaoxue Bai, Zhongmei Wen, Xiufang Zhang, Dong Chen, Liping Peng
Exposure to particulate matter (PM) with an aerodynamic diameter≤2.5μm (PM2.5) induces reactive oxygen species (ROS) and pro-inflammatory cytokine production, leading to airway epithelial injury. However, the mechanisms underlying the toxicity of PM2.5 have not been clarified. Here, we show that exposure to PM2.5 induces sustained activation of the nuclear factor kappa B (NF-κB) signaling in human airway epithelial Beas-2B (B2B) cells. In addition, PM2.5 exposure significantly decreased miR-331 expression in B2B cells, which was abrogated by inhibition of ROS or phosphoinositide 3-kinase (PI3K)/Akt pathway...
February 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28191968/structural-redetermination-and-photoluminescence-properties-of-the-niobium-oxyphosphate-nbo-2p4o13
#11
Daniel Schildhammer, Gerda Fuhrmann, Lucas L Petschnig, Klaus Wurst, Daniela Vitzthum, Markus Seibald, Herwig Schottenberger, Hubert Huppertz
The structure of (NbO)2P4O13 was solved and refined based on new single-crystal diffraction data revealing considerably more complexity than previously described. (NbO)2P4O13 crystallizes in the triclinic space group P1̅ with Z = 6. The lattice parameters determined at room temperature are a = 1066.42(4) pm, b = 1083.09(4) pm, c = 1560.46(5) pm, α = 98.55(1)°, β = 95.57(1)°, γ = 102.92(1)°, and V = 1.7213(2) nm(3). The superstructure contains 64 unique atoms including two disordered semioccupied oxygen positions...
February 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28190687/short-term-effects-of-particle-size-fractions-on-circulating-biomarkers-of-inflammation-in-a-panel-of-elderly-subjects-and-healthy-young-adults
#12
Mohammad Sadegh Hassanvand, Kazem Naddafi, Homa Kashani, Sasan Faridi, Nino Kunzli, Ramin Nabizadeh, Fatemeh Momeniha, Akbar Gholampour, Mohammad Arhami, Ahad Zare, Zahra Pourpak, Mohammad Hoseini, Masud Yunesian
Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10 (PM < 10 μm), PM2.5-10 (PM 2.5-10 μm), PM2.5 (PM < 2.5 μm), PM1-2.5 (PM 1-2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013...
February 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28178064/association-between-senior-obstetrician-supervision-of-resident-deliveries-and-mode-of-delivery
#13
Jonah Bardos, Holly Loudon, Patricia Rekawek, Frederick Friedman, Michael Brodman, Nathan S Fox
OBJECTIVE: In December 2012, the Mount Sinai Hospital implemented a program to have senior obstetricians (more than 20 years of experience) supervise residents on labor and delivery during the daytime. The objective of this study was to estimate the association of resident supervision by senior obstetricians with mode of delivery. METHODS: This was a retrospective cohort study of all resident deliveries at Mount Sinai from July 2011 to June 2015. We included all patients with live, term, singleton, vertex fetuses...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28173713/off-hour-primary-percutaneous-coronary-angioplasty-does-not-affect-contrast-induced-nephropathy-in-patients-with-st-segment-elevation-myocardial-infarction
#14
Yalcin Velibey, Ozan Tanik, Ahmet Oz, Tolga Sinan Guvenc, Koray Kalenderoglu, Ayca Gumusdag, Ozge Guzelburc, Ahmet Ilker Tekkesin, Ahmet Okan Uzun, Ahmet Taha Alper, Mehmet Eren
We evaluated whether primary percutaneous coronary intervention (pPCI) during off-hours is related to an increased incidence of contrast-induced nephropathy (CIN). We retrospectively analyzed the incidence of CIN mortality among 2552 patients with consecutive ST-segment elevation myocardial infarction treated with pPCI during regular hours (weekdays 8:00 am to 5:00 pm) and off-hours (weekdays 5:01 pm to 7:59 am, weekends and holidays). Patients in the off-hour group were more frequently admitted with acute heart failure symptoms (16...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28166316/is-choroidal-or-scleral-thickness-related-to-myopic-macular-degeneration
#15
Chee Wai Wong, Val Phua, Shu Yen Lee, Tien Yin Wong, Chui Ming Gemmy Cheung
Purpose: The relative contribution of mechanical and vascular factors to the pathogenesis of myopic macular degeneration (MMD) is unclear. To address this gap, we examined the association of choroidal thickness (CT) and scleral thickness (ST) with MMD. Methods: Prospective, clinic-based case series of 62 eyes of 41 patients with high myopia (≤-6 diopters or axial length ≥26.5 mm). Swept-source optical coherence tomography (SSOCT) was performed to measure subfoveal CT and ST...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28165040/lead-free-piezoelectrics-v-3-to-v-5-ion-conversion-promoting-the-performances-of-v-doped-zinc-oxide
#16
M Laurenti, M Castellino, D Perrone, A Asvarov, G Canavese, A Chiolerio
Vanadium doped ZnO (VZO) thin films were grown by RF magnetron sputtering, starting from a ZnO:V ceramic target. The crystal structure, chemical composition, electric and piezoelectric properties of the films were investigated either on the as-grown thin films or after a post-deposition rapid thermal annealing (RTA) treatment performed at 600 °C for different lengths of time (1 and 5 min) in an oxygen atmosphere. Substitutional doping of Zn(2+) with V(3+) and V(5+) ions strongly deteriorated the hexagonal wurtzite ZnO structure of the as-grown thin films due to lattice distortion...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163931/circadian-variation-in-the-onset-of-placental-abruption
#17
Masanao Ohhashi, Seishi Furukawa, Hiroshi Sameshima
Objective. To determine circadian variation in the onset of placental abruption. Methods. A retrospective study involving 115 placental abruptions, divided into four subgroups based on initial symptoms comprising abdominal pain, vaginal bleeding, both abdominal pain and bleeding, or other symptoms. The time of the initial symptom was considered the disease onset. We analyzed the frequency of disease onset and adverse perinatal outcome including perinatal death relative to the daily four 6-hour intervals. Results...
2017: Journal of Pregnancy
https://www.readbyqxmd.com/read/28160258/effect-of-microneedles-on-transdermal-permeation-enhancement-of-amlodipine
#18
Buchi N Nalluri, Chandrateja Uppuluri, Jyothirmayee Devineni, Atul Nayak, Karthik J Nair, Benjamin R Whiteside, Diganta B Das
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm(2) skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L(2))...
February 3, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28159306/source-apportionment-of-pm2-5-in-baton-rouge-louisiana-during-2009-2014
#19
Fenglin Han, Sri Harsha Kota, Yungang Wang, Hongliang Zhang
Particulate matter with aerodynamic diameter <2.5μm (PM2.5) chemical composition data from the Speciation Trends Network (STN) site located in Baton Rouge, Louisiana were analyzed using the receptor Positive Matrix Factorization (PMF) model version 5.0. The PM2.5 samples were collected every third day from January 2009 to December 2014. Seven sources were identified, including secondary sulfate, secondary nitrate, industrial emissions, traffic, crustal dust, road dust and sea salt. The contributions of these seven sources to PM2...
January 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28159031/fine-airborne-particles-when-alarming-levels-are-the-standard
#20
M Carugno, C Lagazio, M Baccini, D Consonni, P A Bertazzi, A Biggeri
OBJECTIVES: To quantify the contribution of each individual month to the annual mortality burden attributable to particulate matter (PM) in 2015 in Milan, Italy, after authorities and media considered December 2015 as an outlying month carrying an exceptional population exposure to PM. STUDY DESIGN: We used routinely available daily time series of air pollution and mortality to perform an assessment of the impact of PM exposure on population health. METHODS: By combining daily death counts with daily PM levels, as well as the yearly average of the number of deaths with the yearly average of PM concentrations, impact estimates were calculated in terms of deaths attributable (AD) to levels of PM10 and PM2...
February 2017: Public Health
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