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https://www.readbyqxmd.com/read/29033383/long-term-exposure-to-ambient-air-pollution-and-incidence-of-postmenopausal-breast-cancer-in-15-european-cohorts-within-the-escape-project
#1
Zorana J Andersen, Massimo Stafoggia, Gudrun Weinmayr, Marie Pedersen, Claudia Galassi, Jeanette T Jørgensen, Anna Oudin, Bertil Forsberg, David Olsson, Bente Oftedal, Gunn Marit Aasvang, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L Pedersen, Claes-Göran Östenson, Laura Fratiglioni, Kirsten T Eriksen, Anne Tjønneland, Petra H Peeters, Bas Bueno-de-Mesquita, Michelle Plusquin, Timothy J Key, Andrea Jaensch, Gabriele Nagel, Alois Lang, Meng Wang, Ming-Yi Tsai, Agnes Fournier, Marie-Christine Boutron-Ruault, Laura Baglietto, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Ibon Tamayo-Uria, Pilar Amiano, Miren Dorronsoro, Roel Vermeulen, Ranjeet Sokhi, Menno Keuken, Kees de Hoogh, Rob Beelen, Paolo Vineis, Giulia Cesaroni, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2...
October 13, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29032866/hsp90-maintains-boar-spermatozoa-motility-and-mitochondrial-membrane-potential-during-heat-stress
#2
V Calle-Guisado, M J Bragado, L J García-Marín, L González-Fernández
Heat Shock Proteins (HSP) is a family of proteins that protects cells from high temperatures. The present work aimed to elucidate the role that HSP90 exerts on boar sperm incubated under heat stress conditions on viability, total motility (TM), progressive motility (PM), acrosome status, mitochondrial membrane potential and plasma membrane lipid organization. Sperm were incubated in non-capacitating conditions (Tyrode's basal medium or TBM) for 3, 8 and 24h or in capacitating conditions (Tyrode's complete medium or TCM) for 4h at 38...
September 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29032523/thrombin-generation-test-as-a-marker-for-high-risk-venous-thrombosis-pregnancies
#3
Bérangère S Joly, Bénédicte Sudrié-Arnaud, Virginie Barbay, Jeanne-Yvonne Borg, Véronique Le Cam Duchez
Pregnancy is a well-established risk factor for venous thromboembolism and is associated with a state of hypercoagulability. The use of sensitive and specific biological markers to predict risk factors for thrombosis is essential during pregnancy. Our objective was to investigate the usefulness of thrombin generation test (TGT) as a marker to predict the risk of thrombosis in high risk venous thrombosis (HRVT) pregnancies compared to normal pregnancies. This retrospective study enrolled 134 women with HRVT pregnancies, 78 of whom had monozygotic, spontaneous and untreated pregnancies and formed the study group...
October 14, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29031407/biomass-burning-particles-in-the-brazilian-amazon-region-mutagenic-effects-of-nitro-and-oxy-pahs-and-assessment-of-health-risks
#4
Marcos Felipe de Oliveira Galvão, Nilmara de Oliveira Alves, Paula Anastácia Ferreira, Sofia Caumo, Pérola de Castro Vasconcellos, Paulo Artaxo, Sandra de Souza Hacon, Deborah Arnsdorff Roubicek, Silvia Regina Batistuzzo de Medeiros
Emissions from burning of biomass in the Amazon region have adverse effects on the environment and human health. Herein, particulate matter (PM) emitted from biomass burning in the Amazon region during two different periods, namely intense and moderate, was investigated. This study focused on: i) organic characterization of nitro- and oxy-polycyclic aromatic hydrocarbons (PAHs); ii) assessment of the excess lifetime cancer risk (LCR); and iii) assessment of the in vitro mutagenic effects of extractable organic matter (EOM)...
October 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29031214/land-use-regression-models-for-the-oxidative-potential-of-fine-particles-pm2-5-in-five-european-areas
#5
John Gulliver, David Morley, Chrissi Dunster, Adrienne McCrea, Erik van Nunen, Ming-Yi Tsai, Nicoltae Probst-Hensch, Marloes Eeftens, Medea Imboden, Regina Ducret-Stich, Alessio Naccarati, Claudia Galassi, Andrea Ranzi, Mark Nieuwenhuijsen, Ariadna Curto, David Donaire-Gonzalez, Marta Cirach, Roel Vermeulen, Paolo Vineis, Gerard Hoek, Frank J Kelly
Oxidative potential (OP) of particulate matter (PM) is proposed as a biologically-relevant exposure metric for studies of air pollution and health. We aimed to evaluate the spatial variability of the OP of measured PM2.5 using ascorbate (AA) and (reduced) glutathione (GSH), and develop land use regression (LUR) models to explain this spatial variability. We estimated annual average values (m(-3)) of OP(AA) and OP(GSH) for five areas (Basel, CH; Catalonia, ES; London-Oxford, UK (no OP(GSH)); the Netherlands; and Turin, IT) using PM2...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29031119/index-analysis-and-human-health-risk-model-application-for-evaluating-ambient-air-heavy-metal-contamination-in-chemical-valley-sarnia
#6
Richard Olawoyin, Linda Schweitzer, Kuangyuan Zhang, Oladapo Okareh, Kevin Slates
The impacts of air emissions as a consequence of industrial activities around communities of human habitation have been extensively reported. This study is the first to assess potential adverse human health effects in the Chemical Valley Sarnia (CVS) area, around the St. Clair River, using health risk models, ecological and pollution indices. Large quantities of particulate matters (PM) are generated from anthropogenic activities, which contain several heavy metals in trace quantities with potentially adverse effects to humans and environmental health...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29029407/molecular-profiling-of-colorectal-pulmonary-metastases-and-primary-tumours-implications-for-targeted-treatment
#7
Sing Y Moorcraft, Thomas Jones, Brian A Walker, George Ladas, Eleftheria Kalaitzaki, Lina Yuan, Ruwaida Begum, Zakaria Eltahir, Andrew Wotherspoon, Angeles Montero-Fernandez, Larissa S Teixeira Mendes, David Gonzalez de Castro, Sanna Hulkki Wilson, Paula Proszek, Ye M To, Eliza Hawkes, Amitesh Roy, David Cunningham, Sheela Rao, David Watkins, Naureen Starling, Anne M Bowcock, Ian Chau
This study aimed to molecularly characterise colorectal pulmonary metastases (PM) and investigate whether their molecular profiles were concordant with those of the primary tumour. Clinical data and archival formalin fixed paraffin embedded tissue samples were retrospectively collected from patients who underwent ≥ 1 pulmonary metastasectomies for colorectal cancer between 1997-2012. Primary tumour and metastatic samples were analysed using a targeted capture sequencing panel of 46 cancer-associated genes...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028679/association-between-long-term-exposure-to-traffic-related-air-pollution-and-inflammatory-and-thrombotic-markers-in-middle-aged-adults
#8
Ta-Chen Su, Juey-Jen Hwang, Ya-Ru Yang, Chang-Chuan Chan
BACKGROUND: Studies evaluating possible associations between long-term exposure to air pollution and inflammatory and thrombotic markers are limited. METHODS: From 2009 to 2011, we monitored hematologic parameters and thrombotic markers in 402 volunteers 35-65 years of age who were recruited as the non-coronary heart disease (CHD) controls in a study of work-related factors and CHD in Taipei. We applied land-use regression models developed by the European Study of Cohorts for Air Pollution Effects to estimate the mean annual exposure of each participant to five air pollutants at their residence in Taipei, namely particulate matter (PM) of diameter <10 μm (PM10) and 2...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028054/extended-9-7%C3%A2-%C3%A2-nm-tuning-range-in-a-mopa-system-with-a-tunable-dual-grating-y-branch-laser
#9
Mahmoud Tawfieq, André Müller, Jörg Fricke, Pietro Della Casa, Peter Ressel, David Feise, Bernd Sumpf, Günther Tränkle
In this Letter, we present a tunable Y-branch hybrid master oscillator power amplifier (MOPA) with 5.5 W output power, emitting between 973.7 and 983.4 nm. The MO is a monolithic Y-branch distributed Bragg reflector (DBR) diode laser, which is collimated and coupled into a tapered amplifier using cylindrical microlenses in a compact 25  mm×25  mm conduction cooled laser package. The wavelength spacing between the two laser branches is 2.2 nm. Each branch can be electrically tuned by up to 7.5 nm of quasi-continuous wavelength tuning, which in combination covers up to 9...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027398/nutritional-status-cachexia-and-anorexia-in-women-with-peritoneal-metastasis-and-intraperitoneal-chemotherapy-a-longitudinal-analysis
#10
Ziad Hilal, Günther A Rezniczek, Robert Klenke, Askin Dogan, Clemens B Tempfer
OBJECTIVE: To describe the nutritional status of women with peritoneal metastasis (PM) from recurrent ovarian, fallopian, or peritoneal cancer and to assess longitudinal variations of the cachexia-anorexia syndrome (CAS) during palliative pressurized intraperitoneal aerosol chemotherapy (PIPAC). METHODS: Nutritional assessment included body mass index (BMI), bioelectrical impedance analysis (BIA), and blood chemistry. CAS presence/absence was recorded before and during repeated cycles (1-11) of PIPAC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027009/lipid-lowering-agent-triggered-dermatomyositis-and-polymyositis-a-case-series-and-literature-review
#11
REVIEW
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Rafael Giovane Misse, Samuel Katsuyuki Shinjo
Lipid-lowering agent-triggered dermatomyositis (DM) or polymyositis (PM) is a rare event. Therefore, the aim of the present study was to describe a series of such cases. A retrospective cohort study of 5 DM and 4 PM cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. All patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-SRP or anti-HMGCoAR. Median age of the patients at time of diagnosis was 68 years...
October 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29025984/synthesis-and-biological-evaluation-of-a-novel-18-f-labeled-adnectin-as-a-pet-radioligand-for-imaging-pd-l1-expression
#12
David J Donnelly, Ralph Adam Smith, Paul Morin, Dasa Lipovsek, Jochem Gokemeijer, Daniel Cohen, Virginie Lafont, Tritin Tran, Erin Lee Cole, Martin Wright, Joonyoung Kim, Adrienne Pena, Daniel Kukral, Douglas D Dischino, Patrick Chow, Jinping Gan, Olufemi Adelakun, Xi-Tao Wang, Kai Cao, David Lueng, Samuel Bonacorsi, Wendy Hayes
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET imaging agent for measuring PD-L1 status in primary and metastatic lesions could be important for optimizing drug therapy. Herein, we have evaluated the tumor targeting of an anti-PD-L1 Adnectin after (18)F-fluorine labeling. Methods: An anti-PD-L1 Adnectin was labeled with (18)F in two steps. This synthesis featured fluorination of a novel prosthetic group, followed by a copper-free click conjugation to a modified Adnectin to generate (18)F-BMS-986192...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29024734/clinical-and-dermoscopic-characterization-of-pediatric-and-childhood-melanomas-multicenter-study-of-52-cases
#13
Cristina Carrera, Alon Scope, Stephen W Dusza, Giuseppe Argenziano, Gianluca Nazzaro, Alice Phan, Isabelle Tromme, Pietro Rubegni, Josep Malvehy, Susana Puig, Ashfaq A Marghoob
BACKGROUND: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse and this may in part contribute to delay in detection and thicker tumors. OBJECTIVE: to analyze the clinical-dermoscopic characteristics of PM. METHODS: retrospective study of 52 melanomas diagnosed before age of 20. RESULTS: Based on clinical, dermoscopic and histopathological characteristics, PM can be classified as Spitzoid and Non-Spitzoid Non-Spitzoid (37, 72...
October 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29020926/a-comparison-of-the-use-of-propofol-alone-and-propofol-with-midazolam-for-pediatric-magnetic-resonance-imaging-sedation-a-retrospective-cohort-study
#14
RyungA Kang, Young Hee Shin, Nam-Su Gil, Ki Yoon Kim, Hyean Yeo, Ji Seon Jeong
BACKGROUND: Pediatric MRI sedation performed by a variety of specialists such as sedationists and anesthesiologists commonly uses propofol, which has similar effects to an ideal sedative agent for maintaining deep sedation. However, when propofol is used, adverse airway events are relatively more common than when using other sedative agents. The concomitant administration of midazolam and propofol can reduce the dose of propofol needed for adequate sedation and might also reduce the frequency of airway obstruction without affecting the patient's recovery profile...
October 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29019550/salivary-stress-biomarkers-and-anxiety-symptoms-in-children-with-and-without-temporomandibular-disorders
#15
Fernanda Yukie Kobayashi, Maria Beatriz Duarte Gavião, Maria Carolina Salomé Marquezin, Fernando Luiz Affonso Fonseca, Ana Bheatriz Marangoni Montes, Taís de Souza Barbosa, Paula Midori Castelo
The etiology of temporomandibular disorders (TMD), which are considered as a heterogeneous group of psychophysiological disturbances, remains a controversial issue in clinical dentistry. This study aimed to evaluate whether the salivary alpha-amylase (sAA), cortisol levels, and anxiety symptoms differ between children with and without TMD. Initially, 316 young subjects were screened in public schools (nonreferred sample); 76 subjects aged 7-14 years were selected and comprised the TMD and control groups with 38 subjects each matched by sex, age, and the presence/absence of sleep bruxism...
September 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29019498/characterization-of-carboxylate-nanoparticle-adhesion-with-the-fungal-pathogen-candida-albicans
#16
Amy Lyden, Lisa Lombardi, Wilfried Sire, Peng Li, Jeremy C Simpson, Geraldine Butler, Gil U Lee
Candida albicans is the lead fungal pathogen of nosocomial bloodstream infections worldwide and has mortality rates of 43%. Nanoparticles have been identified as a means to improve medical outcomes for Candida infections, enabling sample concentration, serving as contrast agents for in vivo imaging, and delivering therapeutics. However, little is known about how nanoparticles interact with the fungal cell wall. In this report we used laser scanning confocal microscopy to examine the interaction of fluorescent polystyrene nanoparticles of specific surface chemistry and diameter with C...
October 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29018287/large-piezoelectric-strain-with-ultra-low-strain-hysteresis-in-highly-c-axis-oriented-pb-zr0-52ti0-48-o3-films-with-columnar-growth-on-amorphous-glass-substrates
#17
Minh D Nguyen, Evert P Houwman, Guus Rijnders
Thin films of PbZr0.52Ti0.48O3 (PZT) with largely detached columnar grains, deposited by pulsed laser deposition (PLD) on amorphous glass substrates covered with Ca2Nb3O10 nanosheets as growth template and using LaNiO3 electrode layers, are shown to exhibit very high unipolar piezoelectric strain and ultra-low strain hysteresis. The observed increase of the piezoelectric coefficient with increasing film thickness is attributed to the reduction of clamping, because of the increasingly less dense columnar microstructure (more separation between the grains) with across the film thickness...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017113/fate-of-bisphenol-a-perfluorooctanoic-acid-and-perfluorooctanesulfonate-in-two-different-types-of-sewage-treatment-works-in-hong-kong
#18
Yu Bon Man, Ka Lai Chow, Yiu Fai Tsang, Frankie Tat Kwong Lau, Wing Cheong Fung, Ming Hung Wong
This study aimed at investigating the removal efficiencies of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) of two major sewage treatment works in Hong Kong: Stonecutters Island STW (SCISTW) which adopts chemically enhanced primary treatment (CEPT) process and Sha Tin STW (STSTW) which employs biological treatment. Liquid portion (LP) and particulate matter (PM) of liquid sewage samples and sludge samples were collected and followed by liquid chromatograph system. It was found that BPA (44...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/29016987/long-term-exposure-to-ambient-air-pollution-and-incidence-of-brain-tumor-the-european-study-of-cohorts-for-air-pollution-effects-escape
#19
Zorana J Andersen, Marie Pedersen, Gudrun Weinmayr, Massimo Stafoggia, Claudia Galassi, Jeanette T Jørgensen, Johan N Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Gunn Marit Aasvang, Per Schwarze, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Claes-Göran Östenson, Laura Fratiglioni, Kirsten T Eriksen, Aslak H Poulsen, Anne Tjønneland, Elvira Vaclavik Bräuner, Petra H Peeters, Bas Bueno-de-Mesquita, Andrea Jaensch, Gabriele Nagel, Alois Lang, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Roel Vermeulen, Ranjeet Sokhi, Menno Keuken, Kees de Hoogh, Rob Beelen, Paolo Vineis, Giulia Cesaroni, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent. Methods: In 12 cohorts from six European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤ 2.5, ≤ 10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2...
August 31, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28991813/using-discrete-event-simulation-to-promote-quality-improvement-and-efficiency-in-a-radiation-oncology-treatment-center
#20
Robin M Famiglietti, Emily C Norboge, Valentine Boving, James R Langabeer, Thomas A Buchholz, Osama Mikhail
BACKGROUND: To meet demand for radiation oncology services and ensure patient-centered safe care, management in an academic radiation oncology department initiated quality improvement efforts using discrete-event simulation (DES). Although the long-term goal was testing and deploying solutions, the primary aim at the outset was characterizing and validating a computer simulation model of existing operations to identify targets for improvement. METHODS: The adoption and validation of a DES model of processes and procedures affecting patient flow and satisfaction, employee experience, and efficiency were undertaken in 2012-2013...
October 2017: Quality Management in Health Care
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