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https://www.readbyqxmd.com/read/28541501/satellite-based-estimates-of-long-term-exposure-to-fine-particulate-matter-are-associated-with-c-reactive-protein-in-30%C3%A2-034-taiwanese-adults
#1
Zilong Zhang, Ly-Yun Chang, Alexis K H Lau, Ta-Chien Chan, Yuan Chieh Chuang, Jimmy Chan, Changqing Lin, Wun Kai Jiang, Keith Dear, Benny C Y Zee, Eng-Kiong Yeoh, Gerard Hoek, Tony Tam, Xiang Qian Lao
Background: Particulate matter (PM) air pollution is associated with the risk of cardiovascular morbidity and mortality. However, the biological mechanism underlying the associations remains unclear. Atherosclerosis, the underlying pathology of cardiovascular disease, is a chronic inflammatory process. We therefore investigated the association of long-term exposure to fine PM (PM 2.5 ) with C-reactive protein (CRP), a sensitive marker of systemic inflammation, in a large Taiwanese population...
May 25, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28540827/complete-cytoreductive-surgery-plus-hipec-for-peritoneal-metastases-from-unusual-cancer-sites-of-origin-results-from-a-worldwide-analysis-issue-of-the-peritoneal-surface-oncology-group-international-psogi
#2
Diane Goéré, Guillaume Passot, Maximiliano Gelli, Edward A Levine, David L Bartlett, Paul H Sugarbaker, Olivier Glehen
AIM: The aim of this study was to assess the outcomes of patients operated on for peritoneal metastases from unusual cancer sites of origin, meaning apart from PM from colorectal, gastric and epithelial ovarian carcinomas, pseudomyxoma peritonei and mesothelioma. PATIENTS AND METHODS: A questionnaire concerning patients treated with CRS plus HIPEC for PM arising from unusual cancer sites of origin was sent to all centers that routinely performed HIPEC, through the Peritoneal Surface Oncology Group International and the RENAPE network...
March 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28538762/papillary-muscle-free-strain-in-patients-with-severe-degenerative-and-functional-mitral-regurgitation
#3
Alev Kılıcgedik, Gokhan Kahveci, Ahmet Seyfeddin Gurbuz, Can Yucel Karabay, Ahmet Guler, Suleyman Cagan Efe, Soe Moe Aung, Ugur Arslantas, Serdar Demir, Ibrahim Akin Izgi, Cevat Kirma
Fundamento: The role of papillary muscle function in severe mitral regurgitation with preserved and reduced left ventricular ejection fraction and the method of choice to evaluate PM have still been the subjects of controversy. Objectives: To evaluate and compare papillary muscle function in and between patients with severe degenerative and functional mitral regurgitation by using the free strain method. Methods: 64 patients with severe mitral regurgitation - 39 patients with degenerative mitral regurgitation (DMR group) and 25 patients with severe functional mitral regurgitation (FMR group) - and 30 control subjects (control group) were included in the study...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28531217/store-operated-ca2-entry-supports-contractile-function-in-hearts-of-hibernators
#4
Olga V Nakipova, Alexey S Averin, Edward V Evdokimovskii, Oleg Yu Pimenov, Leonid Kosarski, Dmitriy Ignat'ev, Andrey Anufriev, Yuri M Kokoz, Santiago Reyes, Andre Terzic, Alexey E Alekseev
Hibernators have a distinctive ability to adapt to seasonal changes of body temperature in a range between 37°C and near freezing, exhibiting, among other features, a unique reversibility of cardiac contractility. The adaptation of myocardial contractility in hibernation state relies on alterations of excitation contraction coupling, which becomes less-dependent from extracellular Ca2+ entry and is predominantly controlled by Ca2+ release from sarcoplasmic reticulum, replenished by the Ca2+-ATPase (SERCA)...
2017: PloS One
https://www.readbyqxmd.com/read/28528474/toxicity-assessment-of-ash-and-dust-from-handmade-gold-jewelry-manufacturing-workshops-in-bangladesh
#5
Arif M Sikder, Tanvir Hossain, Manzurul H Khan, M Aziz Hasan, M Fakhruzzaman, Joseph B Turner, Dmitry Pestov, Leigh S McCallister, K Maudood Elahi
Traditionally, handmade gold jewelry played a very important role in the cultural heritage of Bangladesh. Goldsmiths still are partially using ancient manufacturing process with coal fire, candle flame blowing, and nitric and sulfuric acid treatments. Such process leads to the contamination of workplace with the dust of toxic metals, acidic vapors, and particles of different natures. To evaluate contamination by particulate matter (PM), the passive particle collectors were installed in different manufacturing units for a period of 85 days at Tanti Bazar, Dhaka, Bangladesh...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28527505/data-sharing-and-data-registries-in-physical-medicine-and-rehabilitation
#6
REVIEW
Carmen E Capó-Lugo, Abel N Kho, Linda C O'Dwyer, Marc B Rosenman
The field of physical medicine & rehabilitation (PM&R), along with all the disciplines it encompasses, has evolved rapidly in the past 50 years. The number of controlled trials, systematic reviews, and meta-analyses in PM&R increased 5-fold from 1998 to 2013. In recent years, professional, private, and governmental institutions have identified the need to track function and functional status across providers and settings of care and on a larger scale. Because function and functional status are key aspects of PM&R, access to and sharing of reliable data will have an important impact on clinical practice...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28521450/atmospheric-particulate-matter2-5-promotes-the-migration-and-invasion-of-hepatocellular-carcinoma-cells
#7
Qian Zhang, Qiong Luo, Xueyu Yuan, Li Chai, Dan Li, Jianjun Liu, Zhongwei Lv
Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was to explore the response of the HCC cell lines HepG2 and HuH-7 to PM2.5 exposure. The results revealed that PM2.5 treatment promoted the migration and invasion of HCC cells, in addition to increasing protein levels of matrix metalloproteinase (MMP)-13...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521192/long-term-exposure-to-residential-ambient-fine-and-coarse-particulate-matter-and-incident-hypertension-in-post-menopausal-women
#8
Trenton Honda, Melissa N Eliot, Charles B Eaton, Eric Whitsel, James D Stewart, Lina Mu, Helen Suh, Adam Szpiro, Joel D Kaufman, Sverre Vedal, Gregory A Wellenius
BACKGROUND: Long-term exposure to ambient particulate matter (PM) has been previously linked with higher risk of cardiovascular events. This association may be mediated, at least partly, by increasing the risk of incident hypertension, a key determinant of cardiovascular risk. However, whether long-term exposure to PM is associated with incident hypertension remains unclear. METHODS: Using national geostatistical models incorporating geographic covariates and spatial smoothing, we estimated annual average concentrations of residential fine (PM2...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28516164/engineered-ligand-based-vegfr-antagonists-with-increased-receptor-binding-affinity-more-effectively-inhibit-angiogenesis
#9
Shiven Kapur, Adam P Silverman, Anne Z Ye, Niv Papo, Darren Jindal, Mark S Blumenkranz, Jennifer R Cochran
Pathologic angiogenesis is mediated by the coordinated action of the vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR2) signaling axis, along with crosstalk contributed by other receptors, notably αvβ3 integrin. We build on earlier work demonstrating that point mutations can be introduced into the homodimeric VEGF ligand to convert it into an antagonist through disruption of binding to one copy of VEGFR2. This inhibitor has limited potency, however, due to loss of avidity effects from bivalent VEGFR2 binding...
March 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28508950/malignancy-as-a-comorbidity-in-rheumatic-diseases-a-retrospective-hospital-based-study
#10
Hai-Long Wang, Yong-Ming Zhou, Guang-Zhao Zhu, Zhu Yang, Bao-Jin Hua
Patients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosing spondylitis (AS), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM), or polymyositis were included. Out of 3982 adult residents admitted to the division of rheumatology, 61 malignancies were observed...
May 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28507521/prime-time-light-exposures-do-not-seem-to-improve-maximal-physical-performance-in-male-elite-athletes-but-enhance-end-spurt-performance
#11
Raphael Knaier, Juliane Schäfer, Anja Rossmeissl, Christopher Klenk, Henner Hanssen, Christoph Höchsmann, Christian Cajochen, Arno Schmidt-Trucksäss
Many sports competitions take place during television prime time, a time of the day when many athletes have already exceeded their time of peak performance. We assessed the effect of different light exposure modalities on physical performance and melatonin levels in athletes during prime time. Seventy-two young, male elite athletes with a median (interquartile range) age of 23 (21; 29) years and maximum oxygen uptake (VO2max) of 63 (58; 66) ml/kg/min were randomly assigned to three different light exposure groups: bright light (BRIGHT), blue monochromatic light (BLUE), and control light (CONTROL)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28507476/effect-of-clopidogrel-on-the-hydroxylation-and-sulfoxidation-of-omeprazole-a-single-dose-study-in-healthy-human-volunteers
#12
Lateef Ahmad, Zafar Iqbal, Shabnam Nazir, Abad Khan, Yasar Shah, Muhammad Imran Khan, Ismail Khan, Amjad Khan
Based upon the known potential interaction between omeprazole (OMP) and clopidogrel (CLOP), the current study was designed to evaluate the effect of CLOP on disposition of OMP and its two major metabolites, 5-hydroxyomeprazole (5-OH-OMP) and omeprazole sulfone (OMP-S) in healthy clinical subjects. A randomized, open label, 2-period, crossover study was designed. Twelve volunteers were selected, of whom eight were extensive metabolizers (EM) of CYP2C19 and 4 were poor metabolizers (PM). They received single dose of OMP either alone or in combination with CLOP (single dose) and samples were collected periodically to calculate various pharmacokinetic parameters...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28505199/stress-and-salivary-cortisol-in-emergency-medical-dispatchers-a-randomized-shifts-control-trial
#13
Sarah Bedini, François Braun, Laurence Weibel, Michel Aussedat, Bruno Pereira, Frédéric Dutheil
Stress at work is a public health concern. Phone operators in emergency medical dispatch centers are particularly at risk. We aimed to demonstrate that the most stressful time for emergency medical dispatchers is the shift when they receive emergency incoming calls, with cortisol as a biomarker of stress. For each emergency medical dispatcher, we measured outcomes over a control day and during three types of shift: Incoming emergency call, Dispatch and Re-assessment. The pattern of shifts was randomized. Saliva was sampled every 15 minutes for 2 hours, i...
2017: PloS One
https://www.readbyqxmd.com/read/28503732/imaging-short-lived-reactive-oxygen-species-ros-with-endogenous-contrast-mri
#14
Rong-Wen Tain, Alessandro M Scotti, Weiguo Li, Xiaohong Joe Zhou, Kejia Cai
PURPOSE: To characterize the relaxation properties of reactive oxygen species (ROS) for the development of endogenous ROS contrast magnetic resonance imaging (MRI). MATERIALS AND METHODS: ROS-producing phantoms and animal models were imaged at 9.4T MRI to obtain T1 and T2 maps. Egg white samples treated with varied concentrations of hydrogen peroxide (H2 O2 ) were used to evaluate the effect of produced ROS in T1 and T2 for up to 4 hours. pH and temperature changes due to H2 O2 treatment in egg white were also monitored...
May 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28501939/dianthin-30-or-gelonin-versus-monomethyl-auristatin-e-each-configured-with-an-anti-calcitonin-receptor-antibody-are-differentially-potent-in-vitro-in-high-grade-glioma-cell-lines-derived-from-glioblastoma
#15
Roger Gilabert-Oriol, Sebastian G B Furness, Brett W Stringer, Alexander Weng, Hendrik Fuchs, Bryan W Day, Angela Kourakis, Andrew W Boyd, David L Hare, Mayank Thakur, Terrance G Johns, Peter J Wookey
We have reported that calcitonin receptor (CTR) is widely expressed in biopsies from the lethal brain tumour glioblastoma by malignant glioma and brain tumour-initiating cells (glioma stem cells) using anti-human CTR antibodies. A monoclonal antibody against an epitope within the extracellular domain of CTR was raised (mAb2C4) and chemically conjugated to either plant ribosome-inactivating proteins (RIPs) dianthin-30 or gelonin, or the drug monomethyl auristatin E (MMAE), and purified. In the high-grade glioma cell line (HGG, representing glioma stem cells) SB2b, in the presence of the triterpene glycoside SO1861, the EC50 for mAb2C4:dianthin was 10...
May 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28499006/clinical-characteristics-and-change-in-the-antibody-titres-of-patients-with-anti-mda5-antibody-positive-inflammatory-myositis
#16
Yoshiyuki Abe, Masakazu Matsushita, Kurisu Tada, Ken Yamaji, Yoshinari Takasaki, Naoto Tamura
Objective.: The aim of this study was to evaluate the clinical characteristics of patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive inflammatory myositis, and the change in anti-MDA5 antibody titres before and after onset. Method.: For 105 PM/DM patients, newly diagnosed in our hospital within the period 2008-2016, serum anti-MDA5 antibody levels were measured at diagnosis and after treatment by ELISA using the MESACUP anti-MDA5 test...
May 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28498778/seasonal-ambient-particulate-matter-and-population-health-outcomes-among-communities-impacted-by-road-dust-in-british-columbia-canada
#17
Kris Y Hong, Gavin H King, Arvind Saraswat, Sarah B Henderson
In recent years, many air quality monitoring programs have favoured measurement of particles less than 2.5 microns (PM2.5) over particles less than 10 microns (PM10) in light of evidence that health impacts are mostly from the fine fraction. However, the coarse fraction (PM10-2.5) may have independent health impacts that support continued measurement of PM10 in some areas, such as those affected by road dust. The objective of this study was to evaluate the associations between different measures of daily PM exposure and two daily indicators of population health in seven communities in British Columbia, Canada, where road dust is an ongoing concern...
May 12, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28495747/reticulon-3-dependent-er-pm-contact-sites-control-egfr-nonclathrin-endocytosis
#18
Giusi Caldieri, Elisa Barbieri, Gilda Nappo, Andrea Raimondi, Massimo Bonora, Alexia Conte, Lisette G G C Verhoef, Stefano Confalonieri, Maria Grazia Malabarba, Fabrizio Bianchi, Alessandro Cuomo, Tiziana Bonaldi, Emanuele Martini, Davide Mazza, Paolo Pinton, Carlo Tacchetti, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund
The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We identified NCE-specific regulators, including the endoplasmic reticulum (ER)-resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critical for EGFR/CD147-NCE, promoting the creation of plasma membrane (PM)-ER contact sites that were required for the formation and/or maturation of NCE invaginations...
May 12, 2017: Science
https://www.readbyqxmd.com/read/28493173/idiopathic-inflammatory-myopathy-and-the-risk-of-venous-thromboembolism-a-meta-analysis
#19
Young Ho Lee, Gwan Gyu Song
This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria...
May 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28489384/rethinking-dithiothreitol-based-particulate-matter-oxidative-potential-measuring-dithiothreitol-consumption-versus-reactive-oxygen-species-generation
#20
Qianshan Xiong, Haoran Yu, Runran Wang, Jinlai Wei, Vishal Verma
We measured the rate of generation of reactive oxygen species (ROS) [hydroxyl radicals ((•)OH) and hydrogen peroxide (H2O2)] catalyzed by ambient particulate matter (PM) in the dithiothreitol (DTT) assay. To understand the mechanism of ROS generation, we tested several redox-active substances, such as 9,10-phenanthrenequinone (PQ), 5-hydroxy-1,4-naphthoquinone (5H-1,4NQ), 1,2-naphthoquinone (1,2-NQ), 1,4-naphthoquinone (1,4-NQ), copper(II), manganese(II), and iron (II and III). Both pure compounds and their mixtures show different patterns in DTT oxidation versus ROS generation...
May 18, 2017: Environmental Science & Technology
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