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JOURNAL ARTICLE
Megha Priyadarshi, Ranveer Singh Jadon, Naval Kishore Vikram, Stanzin Spalkit
A male patient in his early 40s presented to the emergency department with an acute onset of respiratory distress and facial oedema, indicative of anaphylaxis. These symptoms emerged 2 hours subsequent to a wasp sting on the left side of his face. Despite initial stabilisation, the patient's state deteriorated into somnolence and disorientation. Notably, he denied any history of seizures, sensory or motor deficits, or bowel/bladder complications. Physical examination unveiled no focal neurological deficits...
April 10, 2024: BMJ Case Reports
#22
JOURNAL ARTICLE
Gauraang Bhatnagar, Sue Mallett, Richard Beable, Rebecca Greenhalgh, Rajapandian Ilangovan, Hannah Lambie, Evgenia Mainta, Uday Patel, François Porté, Harbir Sidhu, Arun Gupta, Anthony Higginson, Andrew Slater, Damian Tolan, Ian Zealley, Steve Halligan, Stuart A Taylor
OBJECTIVES: To evaluate the additional diagnostic benefit of diffusion weighted imaging (DWI) and contrast enhanced (CE) images during MR enterography (MRE) of Crohn's disease. METHODS: Datasets from 73 patients (mean age 32; 40 male) (28 new-diagnosis, 45 relapsed) were read independently by two radiologists selected from a pool of 13. Radiologists interpreted datasets using three sequential sequence blocks: (1) T2 weighted and steady state free precession gradient echo (SSFP) images alone (T2^); (2) T2 weighted and SSFP images with DWI (T2 + DWI^) and; (3) T2 weighted images, SSFP, DWI and post-contrast enhanced (CE) T1 images (T2 + DWI + CE^), documenting presence, location, and activity of small bowel disease...
April 5, 2024: European Journal of Radiology
#23
JOURNAL ARTICLE
Thomas Van Den Berghe, Bert Verberckmoes, Nicolas Kint, Steven Wallaert, Nicolas De Vos, Chloé Algoet, Maxim Behaeghe, Julie Dutoit, Nadine Van Roy, Philip Vlummens, Amélie Dendooven, Jo Van Dorpe, Fritz Offner, Koenraad Verstraete
OBJECTIVES: Cytogenetic abnormalities are predictors of poor prognosis in multiple myeloma (MM). This paper aims to build and validate a multiparametric conventional and functional whole-body MRI-based prediction model for cytogenetic risk classification in newly diagnosed MM. METHODS: Patients with newly diagnosed MM who underwent multiparametric conventional whole-body MRI, spinal dynamic contrast-enhanced (DCE-)MRI, spinal diffusion-weighted MRI (DWI) and had genetic analysis were retrospectively included (2011-2020/Ghent University Hospital/Belgium)...
April 10, 2024: Insights Into Imaging
#24
JOURNAL ARTICLE
Martha Foltyn-Dumitru, Marianne Schell, Felix Sahm, Tobias Kessler, Wolfgang Wick, Martin Bendszus, Aditya Rastogi, Gianluca Brugnara, Philipp Vollmuth
BACKGROUND: This study investigates the influence of diffusion-weighted Magnetic Resonance Imaging (DWI-MRI) on radiomic-based prediction of glioma types according to molecular status and assesses the impact of DWI intensity normalization on model generalizability. METHODS: Radiomic features, compliant with image biomarker standardization initiative standards, were extracted from preoperative MRI of 549 patients with diffuse glioma, known IDH, and 1p19q-status. Anatomical sequences (T1, T1c, T2, FLAIR) underwent N4-Bias Field Correction (N4) and WhiteStripe normalization (N4/WS)...
2024: Neuro-oncology advances
#25
JOURNAL ARTICLE
William A Mehan, Donghoon Shin, Karen Buch
PURPOSE: Recent publications have suggested incorporating coronal diffusion-weighted imaging (DWI) sequences and axial DWI sequences to enhance the detection of posterior fossa infarcts (PFIs). This study evaluated the utility of coronal DWIs compared with axial DWIs for assessing PFIs in the emergency department (ED). METHODS: A retrospective, institutional review board-approved study was conducted at a level I stroke center, including 118 patients who presented to the ED between 2016 and 2023 with suspected PFI...
April 8, 2024: Journal of Computer Assisted Tomography
#26
JOURNAL ARTICLE
Arash O Naghavi, J M Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E Gloria, George Yang, Stephen A Rosenberg, Kamran Ahmed, Marilyn M Bui, Evita B Henderson-Jackson, Andrew Lee, Caitlin D Lee, Ricardo J Gonzalez, Vladimir Feygelman, Steven A Eschrich, Jacob G Scott, Javier Torres-Roca, Kujtim Latifi, Nainesh Parikh, James Costello
BACKGROUND: Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT is associated with improved patient outcome. Genomic adjusted radiation dose (GARD), a radiation-specific metric that quantifies the expected RT treatment effect as a function of tumor dose and genomics, proposed that STS is significantly underdosed...
April 9, 2024: BMC Cancer
#27
JOURNAL ARTICLE
Elizabeth A Leighton, Chelsea N Gale, En Huang, Xu Yang, Erin L DiCaprio, Xinhui Li
Fresh vegetables can harbor antibiotic-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. Enterobacter hormaechei is a bacterium belonging to the Enterobacterales order and the most commonly identified nosocomial pathogen of Enterobacter cloacae complex. The purpose of this study was to characterize a multi-drug resistant ESBL-producing E. hormaechei strain isolated from a sample of mixed sprouts. Vegetable samples were pre-enriched in buffered peptone water, followed by enrichment in Enterobacteria Enrichment Broth, and isolation on Chromagar™ ESBL plates...
April 9, 2024: Current Microbiology
#28
JOURNAL ARTICLE
Hemalatha Bhagavan, Aguan D Wei, Luiz M Oliveira, Kimberly A Aldinger, Jan-Marino Ramirez
Chronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice exposed to CIH for 21 days, comparing to normoxic controls...
April 9, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
#29
JOURNAL ARTICLE
Huan Han, Shu-Yi Yin, Rui-Xiang Song, Jing Zhao, Yong-Wei Yu, Miao-Xia He, Han Wang
BACKGROUND: Papillary renal neoplasm with reverse polarity (PRNRP) is a novel entity with unique clinicopathological characteristics, and only a small number of patients with PRNRP have been described. METHODS: We retrospectively analyzed the data for nine patients with PRNRP and evaluated differences in the clinical, histomorphological, immunohistochemical, and molecular features; prognosis; and differential diagnosis of PRNRP from other renal tumors with papillary structure...
March 31, 2024: Translational Andrology and Urology
#30
TSC2 nonsense mutation in angiomyolipoma with epithelial cysts: a case report and literature review.
Hong Song, Guoliang Mao, Nanlin Jiao, Jiajia Li, Wanwan Gao, Yinhua Liu, Linming Lu
BACKGROUND: Angiomyolipoma with epithelial cysts (AMLEC) is an extremely rare subtype of kidney angiomyolipoma that contains epithelial-lined cysts. The most distinctive immunohistochemical feature of AMLEC is its immunoreactivity with melanocytic markers. AMLEC also has a distinct histological structure, which aids in its pathological diagnosis. To date 27 cases of AMLEC have been reported in 11 case series. However, the molecular biology underlying the pathogenesis of AMLEC remains unexplored...
2024: Frontiers in Oncology
#31
JOURNAL ARTICLE
Natalia Lutsik, Siamak P Nejad-Davarani, Alessandro Valderrama, Janette Herr, Danilo Maziero, Kaylie Cullison, Gregory A Azzam, Gregory J Kubicek, Jessica Meshman, Macarena I de la Fuente, Tess Armstrong, Eric A Mellon
BACKGROUND: MRI-Linac systems enable daily diffusion-weighed imaging (DWI) MRI scans for assessing glioblastoma tumor changes with radiotherapy treatment. PURPOSE: Our study assessed the image quality of echoplanar imaging (EPI)-DWI scans compared with turbo spin echo (TSE)-DWI scans at 0.35 Tesla (T) and compared the apparent diffusion coefficient (ADC) values and distortion of EPI-DWI on 0.35 T MRI-Linac compared to high-field diagnostic MRI scanners. METHODS: The calibrated National Institute of Standards and Technology (NIST)/Quantitative Imaging Biomarkers Alliance (QIBA) Diffusion Phantom was scanned on a 0...
April 8, 2024: Medical Physics
#32
JOURNAL ARTICLE
Anne-Mari Holte Flusund, Lars Eirik Bø, Ingerid Reinertsen, Ole Solheim, Toril Skandsen, Asta Kristine Håberg, Nada Andelic, Anne Vik, Kent Gøran Moen
Traumatic axonal injury (TAI) is a common finding on MRI in patients with moderate - severe traumatic brain injury (TBI), and the burden of TAI is associated with outcome in this patient group. Lesion mapping offers a way to combine imaging findings from numerous individual patients into common lesion maps where the findings from a whole patient cohort can be assessed. The aim of this study was to evaluate the spatial distribution of traumatic axonal injury (TAI) lesions on different MRI sequences and its associations to outcome with use of lesion mapping...
April 8, 2024: Journal of Neurotrauma
#33
JOURNAL ARTICLE
Yi Tu, Luchao Huang, Xingwang Cheng, Bingchu Tian, Dongling Zhang, Jun Hu, Honghe Ding, Qian Xu, Yifan Ye, Junfa Zhu
Structure-optimized bimetallic and multicomponent catalysts often outperform single-component catalysts, inspiring a detailed investigation of metal-metal and metal-support interactions in the system. We investigated the geometric and electronic structures of ceria-supported Ni-Cu particles prepared using different metal deposition sequences employing a combination of X-ray photoelectron spectroscopy, resonant photoemission spectroscopy, and infrared reflection absorption spectroscopy. The bimetallic model catalyst structure was altered by a distinct surface evolution process determined by the metal deposition sequence...
April 8, 2024: Journal of Physical Chemistry Letters
#34
JOURNAL ARTICLE
Jens Johansson, Kerstin Lagerstrand, Isabella M Björkman-Burtscher, Mats Laesser, Hanna Hebelka, Stephan E Maier
OBJECTIVES: Increasing gradient performance on modern magnetic resonance imaging scanners has profoundly reduced the attainable diffusion and echo times for clinically available pulsed-gradient spin echo (PGSE) sequences. This study investigated how this may impact the measured apparent diffusion coefficient (ADC), which is considered an important diagnostic marker for differentiation between normal and abnormal brain tissue and for therapeutic follow-up. MATERIALS AND METHODS: Diffusion time and echo time dependence of the ADC were evaluated on a high-performance 3 T magnetic resonance imaging scanner...
April 9, 2024: Investigative Radiology
#35
JOURNAL ARTICLE
Pallavi Rai, Jeffrey M Marano, Lin Kang, Sheryl Coutermarsh-Ott, Andrea R Daamen, Peter E Lipsky, James Weger-Lucarelli
Obesity has been identified as an independent risk factor for severe outcomes in humans with coronavirus disease 2019 (COVID-19) and other infectious diseases. Here, we established a mouse model of COVID-19 using the murine betacoronavirus, mouse hepatitis virus 1 (MHV-1). C57BL/6 and C3H/HeJ mice exposed to MHV-1 developed mild and severe disease, respectively. Obese C57BL/6 mice developed clinical manifestations similar to those of lean controls. In contrast, all obese C3H/HeJ mice succumbed by 8 days postinfection, compared to a 50% mortality rate in lean controls...
April 2024: Journal of Medical Virology
#36
Yui Lo, Yuqian Chen, Dongnan Liu, Wan Liu, Leo Zekelman, Fan Zhang, Yogesh Rathi, Nikos Makris, Alexandra J Golby, Weidong Cai, Lauren J O'Donnell
Shape plays an important role in computer graphics, offering informative features to convey an object's morphology and functionality. Shape analysis in brain imaging can help interpret structural and functionality correlations of the human brain. In this work, we investigate the shape of the brain's 3D white matter connections and its potential predictive relationship to human cognitive function. We reconstruct brain connections as sequences of 3D points using diffusion magnetic resonance imaging (dMRI) tractography...
March 30, 2024: ArXiv
#37
JOURNAL ARTICLE
Hirofumi Rokutan, Yasuhito Arai, Akiko Kunita, Satoshi Yamasaki, Hiromi Nakamura, Natsuko Hama, Atsuhito Nakayama, Fumie Hosoda, Yasushi Totoki, Mitsuhiro Fujishiro, Yasuyuki Seto, Tatsuhiro Shibata, Tetsuo Ushiku
Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a slow-growing neoplasm with an indolent clinical course; however, a subset demonstrates transformation into adenocarcinoma with higher-grade histology, typically diffuse-type carcinoma, and behaves aggressively. This study aimed to better characterize the genomic and pathologic features, with a focus on factors associated with diffuse-type transformation...
April 8, 2024: American Journal of Surgical Pathology
#38
JOURNAL ARTICLE
Laura Mumoli, Giuseppe Magro, Emilio Le Piane, Domenico Bosco
BACKGROUND: ABGAs are historically associated with Encephalitis Lethargica (EL). Typically ABGAs are also found in children resulting in a variety of neuropsychiatric and extrapyramidal disorders, rare cases are reported in adults with atypical movement disorders. No description of basal ganglia reversible lesions related to ABGAs are reported and these antibodies are not included in the list of autoimmune encephalitis. METHODS AND RESULTS: A 55 years old female presented sub-acute onset of an anxious-depressive disorder and obsessive-compulsive behavior associated with intractable insomnia affecting sleep onset and sleep maintenance...
March 26, 2024: Sleep Medicine
#39
JOURNAL ARTICLE
Conghao Wang, Hiok Hian Ong, Shunsuke Chiba, Jagath C Rajapakse
Discovering hit molecules with desired biological activity in a directed manner is a promising but profound task in computer-aided drug discovery. Inspired by recent generative AI approaches, particularly Diffusion Models (DM), we propose Graph Latent Diffusion Model (GLDM)-a latent DM that preserves both the effectiveness of autoencoders of compressing complex chemical data and the DM's capabilities of generating novel molecules. Specifically, we first develop an autoencoder to encode the molecular data into low-dimensional latent representations and then train the DM on the latent space to generate molecules inducing targeted biological activity defined by gene expression profiles...
March 27, 2024: Briefings in Bioinformatics
#40
JOURNAL ARTICLE
Arnault Tauziède-Espariat, Yvan Nicaise, Philipp Sievers, Felix Sahm, Andreas von Deimling, Delphine Guillemot, Gaëlle Pierron, Mathilde Duchesne, Myriam Edjlali, Volodia Dangouloff-Ros, Nathalie Boddaert, Alexandre Roux, Edouard Dezamis, Lauren Hasty, Benoît Lhermitte, Edouard Hirsch, Maria Paola Valenti Hirsch, François-Daniel Ardellier, Mélodie-Anne Karnoub, Marie Csanyi, Claude-Alain Maurage, Karima Mokhtari, Franck Bielle, Valérie Rigau, Thomas Roujeau, Marine Abad, Sébastien Klein, Michèle Bernier, Catherine Horodyckid, Clovis Adam, Petter Brandal, Pitt Niehusmann, Quentin Vannod-Michel, Corentin Provost, Nicolas Menjot de Champfleur, Lucia Nichelli, Alice Métais, Cassandra Mariet, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro-Coste, Pascale Varlet
A novel methylation class, "neuroepithelial tumor, with PLAGL1 fusion" (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an ependymal differentiation. Because of the recent identification of this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present a detailed series of nine cases of PLAGL1-fused supratentorial tumors, reclassified from a series of supratentorial ependymomas, non-ZFTA/non-YAP1 fusion-positive and subependymomas of the young...
April 5, 2024: Acta Neuropathologica Communications
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