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Iron chelation

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https://www.readbyqxmd.com/read/28735319/intracellular-siderophore-detection-in-an-egyptian-cobalt-treated-f-solani-isolate-using-sem-edx-with-reference-to-its-tolerance
#1
Rasha M Farrag
An Egyptian, plant pathogenic Fusarium solani isolate was grown on cobalt concentrations of 0, 50, 200, 500, 800, and 1000 ppm. The isolate survived concentrations up to 800 ppm, however failed to grow at 1000 ppm. Morphology and elemental analysis of the isolate under the investigated Co concentrations were studied using Scanning electron microscopy (SEM) and energy dispersive X-ray microanalysis (EDX). The isolate reserved its morphology up to a concentration of 200 ppm. Morphological distortions were dramatic at 500 and 800 ppm...
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28734582/the-hydrolytic-susceptibility-of-prochelator-bsih-in-aqueous-solutions
#2
Qin Wang, Katherine J Franz
The prochelator BSIH ((E)-N'-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) contains a boronate group that prevents metal coordination until reaction with peroxide releases the iron chelator SIH ((E)-N'-(2-hydroxybenzylidene)isonicotinohydrazide). BSIH exists in aqueous buffer and cell culture media in equilibrium with its hydrolysis products isoniazid and (2-formylphenyl)boronic acid (FBA). The relative concentrations of these species limit the yield of intact SIH available for targeted iron chelation...
July 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28730969/the-battle-for-iron-between-humans-and-microbes
#3
Peggy L Carver
Iron is an essential micronutrient for bacteria, fungi, and humans; as such, each has evolved specialized iron uptake systems to acquire iron from the extracellular environment and a complex 'tug of war' has evolved between human hosts and pathogenic microorganisms in the battle for this vital nutrient. In humans, sequestration (hiding) of iron from invading pathogens is often successful; however, many pathogens have evolved mechanisms to circumvent this approach. Clinically, controversy continues whether iron overload or administration of iron results in an increased risk of infection...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28727296/chitosan-fe-iii-complex-as-a-phosphate-chelator-in-uraemic-rats-a-novel-treatment-option
#4
Wander Barros do Carmo, Bárbara Bruna Abreu Castro, Clóvis Antônio Rodrigues, Melani Ribeiro Custódio, Helady Sanders-Pinheiro
Phosphate retention and hyperphosphataemia are associated with increased mortality in chronic kidney disease (CKD) patients. We tested the use of cross-linked iron chitosan III (CH-FeCl) as a potential phosphate chelator in rats with CKD. We evaluated 96 animals, divided equally into 4 groups (control, CKD, CH-FeCl, and CKD/CH-FeCl), over 7 weeks. We induced CKD by feeding animals an adenine-enriched diet (0.75% in the first 4 weeks and 0.1% in the following 3 weeks). We administered 30 mg/kg daily of the test polymer, by gavage, from the third week until the end of the study...
July 20, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28723082/mixed-valency-in-a-3d-semiconducting-iron-fluoranilate-coordination-polymer
#5
Ryuichi Murase, Brendan F Abrahams, Deanna M D'Alessandro, Casey G Davies, Timothy A Hudson, Guy N L Jameson, Boujemaa Moubaraki, Keith S Murray, Richard Robson, Ashley L Sutton
A pair of coordination polymers of composition (NBu4)2[M2(fan)3] (fan = fluoranilate; M = Fe and Zn) were synthesized and structurally characterized. In each case the compound consists of a pair of interpenetrating three-dimensional, (10,3)-a networks in which metal centers are linked by chelating/bridging fluoranilate ligands. Tetrabutylammonium cations are located in the spaces between the two networks. Despite the structural similarity, significant differences exist between (NBu4)2[Fe2(fan)3] and (NBu4)2[Zn2(fan)3] with respect to the oxidation states of the metal centers and ligands...
July 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28721605/how-to-provide-gadolinium-free-pet-mr-cancer-staging-of-children-and-young-adults-in-less-than-1%C3%A2-h-the-stanford-approach
#6
Anne M Muehe, Ashok J Theruvath, Lillian Lai, Maryam Aghighi, Andrew Quon, Samantha J Holdsworth, Jia Wang, Sandra Luna-Fineman, Neyssa Marina, Ranjana Advani, Jarrett Rosenberg, Heike E Daldrup-Link
PURPOSE: To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [(18)F]FDG (2-3 MBq/kg)...
July 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28719386/is-there-a-standard-of-care-for-transfusion-therapy-in-thalassemia
#7
Massimo Franchini, Gian L Forni, Giancarlo M Liumbruno
PURPOSE OF REVIEW: Thalassemia is the most common form of inherited anemia, characterized by variable clinical phenotypes. The purpose of this review is to summarize the transfusion support in thalassemia patients and the management of transfusion-related iron overload. RECENT FINDINGS: The most recent evidence on transfusion strategy and iron chelation therapy in thalassemia arising from clinical trials as well as from recommendation guidelines are critically discussed...
July 14, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28715216/long-term-effect-of-a-leonardite-iron-humate-improving-fe-nutrition-as-revealed-in-silico-in-vivo-and-in-field-experiments
#8
Maria Teresa Cieschi, Marcos Caballero-Molada, Nieves Menéndez, Miguel Ángel Naranjo, Juan J Lucena
Novel, cheap and ecofriendly fertilizers that solve the usual iron deficiency problem in calcareous soil are needed. The aim of this work is to study the long term effect of an iron leonardite fertilizer on citrus nutrition taking into account a properly characterization, kinetic response with a ligand competition experiment, efficiency assessment using Saccharomyces cerevisiae strain and finally, in field conditions with citrus as test plants. Its efficiency was compared with the synthetic iron chelate FeEDDHA...
July 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28715006/substitution-reactions-of-iron-ii-carbamoyl-thioether-complexes-related-to-mono-iron-hydrogenase
#9
Zhu-Lin Xie, Gummadi Durgaprasad, Azim K Ali, Michael J Rose
A C,N,S pincer complex has been synthesized for structural modeling of the organometallic active site of mono-[Fe] hydrogenase (HMD). The C,N,S chelate allows for systematic investigation of the substitution reactions of CO and other exogenous X/L-type ligands, as well as examination of the exact roles of the Fe-carbamoyl and {Fe(CO)2}(2+) units in stabilizing the low-spin Fe(ii) center. Reaction of the 'apo-ligand' 6-(2-(methylthio)phenyl)pyridin-2-amine ((H2N)N(py)S(Me)) with [Fe(CO)4(Br)2] affords the organometallic complex [((O[double bond, length as m-dash])C(NH)N(py)S(Me))Fe(CO)2(Br)] (1)...
July 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28714505/the-antiproliferative-activity-of-di-2-pyridylketone-dithiocarbamate-is-partly-attributed-to-catalase-inhibition-detailing-the-interaction-by-spectroscopic-methods
#10
Cuiping Li, Youxun Liu, Yun Fu, Tengfei Huang, Lixia Kang, Changzheng Li
The bioactivity of drugs is attributed to their interaction with biological molecules, embodied in either their direct or indirect influence on enzyme activity and conformation. Di-2-pyridylketone hydrazine dithiocarbamate (DpdtC) exhibits significant antitumor activity in our preliminary study. We speculated that its activity may partly stem from enzyme inhibition due to strong metal chelating ability. To this end, we assessed its effect on catalase from erythrocytes and found evidence of inhibition, which was further confirmed by ROS determination in vivo...
July 17, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28708597/mri-based-evaluation-of-multiorgan-iron-overload-is-a-predictor-of-adverse-outcomes-in-pediatric-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#11
Natalia Maximova, Massimo Gregori, Giulia Boz, Roberto Simeone, Davide Zanon, Giulia Schillani, Floriana Zennaro
The medical records of 44 pediatric patients who underwent allogeneic transplantation from 2011 to 2015 were retrospectively reviewed. Magnetic resonance imaging was used to measure iron concentrations in the liver, spleen, pancreas and bone. These patients were divided into two groups, 18 with non-elevated (< 100 μmol/g; Group 1) liver iron concentration before transplantation and 26 with elevated (> 100 μmol/g; Group 2) concentration . We compared transplant-related outcomes in the two groups. Iron overload was a negative prognostic risk factor for sinusoidal obstruction syndrome (OR = 17), osteoporosis (OR = 6...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28708324/ferrichrome-has-found-its-match-biomimetic-analogs-with-diversified-activity-map-discrete-microbial-targets
#12
Jenny Besserglick, Evgenia Olshvang, Agnieszka Szebesczyk, Joseph Englander, Dana Levinson, Yitzhak Hadar, Elzbieta Gumienna-Kontecka, Abraham Shanzer
Siderophores provide an established platform for studying molecular recognition principles in biological systems. Herein we describe the preparation of ferrichrome biomimetic analogs varying in length and polarity of the amino acid chain separating between the tripodal scaffold and the pendent FeIII chelating hydroxamic acid groups. Spectroscopic and potentiometric titrations determined their iron affinity to be within the range of efficient chelators. Microbial growth promotion and iron uptake studies were conducted on E...
July 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28707012/soluble-form-of-transferrin-receptor-1-level-is-associated-with-the-age-at-first-diagnosis-and-the-risk-of-therapeutic-intervention-and-iron-overloading-in-patients-with-non-transfusion-dependent-thalassemia
#13
Paolo Ricchi, Antonella Meloni, Silvia Costantini, Anna Spasiano, Tiziana Di Matola, Alessia Pepe, Patrizia Cinque, Aldo Filosa
We retrospectively evaluated the relationship between serum transferrin receptor-1 (sTfR1) and some fundamental events in the life and the management (the age at diagnosis, the age at the first red blood cells transfusion, the age at splenectomy, and the overall need of chelation therapy) of 111 patients with non-transfusion-dependent thalassemia (NTDT) subdivided in four genetic entities: patients with homozygous or compound heterozygous state for β-thalassemia, patients with triplicated α genotype associated with β heterozygosity, patients with deletional HbH, and patients with the combination of a β defect plus a β chain variant...
July 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28706555/advances-in-iron-chelation-therapy-transitioning-to-a-new-oral-formulation
#14
Nirmish R Shah
Iron overload is a concern for patients who require repeated red-blood-cell transfusions due to conditions such as sickle cell disease, thalassemia, or myelodysplastic syndromes. The recommended treatment for removing excess iron in these patients is iron chelation therapy. Currently available iron chelators include deferoxamine, which is administered by injection, and deferasirox and deferiprone, both of which are administered orally. Adherence to iron chelator therapy is an important consideration and may be affected by side effects...
2017: Drugs in Context
https://www.readbyqxmd.com/read/28699741/iron-ii-complexes-of-2-4-dipyrazolyl-1-3-5-triazine-derivatives-the-influence-of-ligand-geometry-on-metal-ion-spin-state
#15
Izar Capel Berdiell, Rafal Kulmaczewski, Malcolm A Halcrow
Seven [FeL2][BF4]2 complex salts were prepared, where L is a 6-substituted 2,4-di(pyrazol-1-yl)-1,3,5-triazine (bpt) derivative. The complexes are all crystallographically high-spin, and exhibit significant distortions from an ideal D2d-symmetric coordination geometry. In one case, an unusual type of metal ion disorder was observed among a cubic array of ligands in the crystal lattice. The complexes are also high-spin between 3 and 300 K in the solid state and, where measured, between 239 and 333 K in CD3CN solution...
July 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28698851/impact-of-labile-plasma-iron-and-iron-chelation-on-the-viability-of-cultured-mononuclear-cells-from-patients-undergoing-autologous-hematopoietic-stem-cell-transplantation
#16
Flávio Augusto Naoum, Breno Pannia Espósito, Idiberto José Zotarelli Filho
No abstract text is available yet for this article.
June 2017: Blood Research
https://www.readbyqxmd.com/read/28698780/liver-iron-content-lic-in-adults-with-sickle-cell-disease-scd-correlation-with-serum-ferritin-and-liver-enzymes-concentrations-in-trasfusion-dependent-td-scd-and-non-transfusion-dependent-nt-scd-patients
#17
Mohamed Yassin, Ashraf Soliman, Vincenzo De Sanctis, Abdelqadir Nashwan, Sandra Abusamaan, Abbas Moustafa, Samah Kohla, Dina Soliman
INTRODUCTION: Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its management. THE AIM OF OUR STUDY: To determine the iron status of 17 patients with non-transfusion-dependent sickle cell disease ( NT-SCD) patients and six patients with transfusion dependent sickle cell disease (TD- SCD) using both serum ferritin level (SF) and Ferriscan® evaluation of liver iron content (LIC)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28695856/crystal-structure-of-yersinia-pestis-virulence-factor-yfea-reveals-two-polyspecific-metal-binding-sites
#18
Christopher D Radka, Lawrence J DeLucas, Landon S Wilson, Matthew B Lawrenz, Robert D Perry, Stephen G Aller
Gram-negative bacteria use siderophores, outer membrane receptors, inner membrane transporters and substrate-binding proteins (SBPs) to transport transition metals through the periplasm. The SBPs share a similar protein fold that has undergone significant structural evolution to communicate with a variety of differentially regulated transporters in the cell. In Yersinia pestis, the causative agent of plague, YfeA (YPO2439, y1897), an SBP, is important for full virulence during mammalian infection. To better understand the role of YfeA in infection, crystal structures were determined under several environmental conditions with respect to transition-metal levels...
July 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28695249/first-study-on-iron-complexes-in-blood-and-organ-samples-from-thalassaemic-and-normal-laboratory-mice-using-m%C3%A3-ssbauer-spectroscopy
#19
George Charitou, Vlassis Petousis, Charalambos Tsertos, Yannis Parpottas, Marina Kleanthous, Marios Phylactides, Soteroula Christou
Measurements of iron complexes and iron stores in the body are crucial for evaluation and management of chelation therapy targeted against iron accumulation or overload in blood and organs. In this work, blood and tissue samples from one normal and one thalassaemic laboratory mouse were studied using (57)Fe Mössbauer spectroscopy at 78 K for the first time. In contrast to human patients, these laboratory mice did not receive any medical treatment, thus the iron components present in the samples are not altered from their natural state...
July 10, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28693496/interaction-of-%C3%AE-fe2o3-nanoparticles-with-citrus-maxima-leaves-and-the-corresponding-physiological-effects-via-foliar-application
#20
Jing Hu, Huiyuan Guo, Junli Li, Yunqiang Wang, Lian Xiao, Baoshan Xing
BACKGROUND: Nutrient-containing nanomaterials have been developed as fertilizers to foster plant growth and agricultural yield through root applications. However, if applied through leaves, how these nanomaterials, e.g. γ-Fe2O3 nanoparticles (NPs), influence the plant growth and health are largely unknown. This study is aimed to assess the effects of foliar-applied γ-Fe2O3 NPs and their ionic counterparts on plant physiology of Citrus maxima and the associated mechanisms. RESULTS: No significant changes of chlorophyll content and root activity were observed upon the exposure of 20-100 mg/L γ-Fe2O3 NPs and Fe(3+)...
July 11, 2017: Journal of Nanobiotechnology
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