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https://www.readbyqxmd.com/read/29448151/functional-cortical-source-connectivity-of-resting-state-electroencephalographic-alpha-rhythms-shows-similar-abnormalities-in-patients-with-mild-cognitive-impairment-due-to-alzheimer-s-and-parkinson-s-diseases
#1
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Maria Francesca De Pandis, Laura Vacca, Giovanni B Frisoni, Fabrizio Stocchi
OBJECTIVE: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). METHODS: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources...
January 31, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29439335/abnormalities-of-resting-state-cortical-eeg-rhythms-in-subjects-with-mild-cognitive-impairment-due-to-alzheimer-s-and-lewy-body-diseases
#2
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Maria Francesca De Pandis, Laura Bonanni
The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29429257/-clinical-features-and-gene-analysis-of-tbc1d24-gene-mutation-related-early-onset-focal-myoclonic-epilepsy
#3
X R Leng, J Ye, Q L Zhou, X H Qi, Y H Dong, L P Zhang, Y F Zhang, Y P Wang, L P Li, Y C Lin
Objective: To investigate the clinical features and genetic characteristics of patients with TBC1D24 gene mutation related early-onset focal myoclonic epilepsy. Methods: Clinical data of 3 patients with TBC1D24 gene mutation related early-onset focal myoclonic epilepsy of Xuanwu Hospital from November 2016 to June 2017 was collected and analyzed.Candidate gene mutations were screened by second generation sequencing. Results: Among the 3 patients, 1 was male and 2 were females.Seizure onset age was 4 months, 3 years and 5 years after birth respectively...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29423131/oscillatory-rhythm-of-reward-anticipation-and-processing-of-rewards-in-children-with-and-without-autism
#4
Katherine Kuhl-Meltzoff Stavropoulos, Leslie J Carver
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, and multiple theories have emerged concerning core social deficits. While the social motivation hypothesis proposes that deficits in the social reward system cause individuals with ASD to engage less in social interaction, the overly intense world hypothesis (sensory over-responsivity) proposes that individuals with ASD find stimuli to be too intense and may have hypersensitivity to social interaction, leading them to avoid these interactions...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29421325/localizing-bicoherence-from-eeg-and-meg
#5
Forooz Shahbazi Avarvand, Sarah Bartz, Christina Andreou, Wojciech Samek, Gregor Leicht, Christoph Mulert, Andreas K Engel, Guido Nolte
We propose a new method for the localization of nonlinear cross-frequency coupling in EEG and MEG data analysis, based on the estimation of bicoherences at the source level. While for the analysis of rhythmic brain activity, source directions are commonly chosen to maximize power, we suggest to maximize bicoherence instead. The resulting nonlinear cost function can be minimized effectively using a gradient approach. We argue, that bicoherence is also a generally useful tool to analyze phase-amplitude coupling (PAC), by deriving formal relations between PAC and bispectra...
February 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29407464/abnormalities-of-resting-state-functional-cortical-connectivity-in-patients-with-dementia-due-to-alzheimer-s-and-lewy-body-diseases-an-eeg-study
#6
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Laura Vacca, Maria Francesca De Pandis, Laura Bonanni
Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB...
December 30, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29381405/the-influences-of-cholecystectomy-on-the-circadian-rhythms-of-bile-acids-as-well-as-the-enterohepatic-transporters-and-enzymes-systems-in-mice
#7
Fan Zhang, Yingting Duan, Lili Xi, Mengmeng Wei, Axi Shi, Yan Zhou, Yuhui Wei, Xinan Wu
Bile acids (BAs), the most important endogenous and signaling molecules regulate the target transporters and enzymes at transcriptional level, participate in a wide variety of processes throughout the entire gastrointestinal tract to orchestrate homeostasis in vivo. BAs and their metabolism and transportation appear to follow the clear circadian rhythms, and they are recently proposed also as the potential chronobiological signals that can affect the molecular clock mechanism. Cholecystectomy are believed to affect the circadian rhythms of BAs and the relevant enterohepatic transporters and enzymes systems and their regulatory signaling pathways, for the reason that the circadian cycle of gallbladder filling and emptying play a pivotal role in controlling the flow of bile into the intestine and the enterohepatic circulation of BAs...
January 30, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29379042/maturation-of-pain-empathy-from-child-to-adult-shifts-from-single-to-multiple-neural-rhythms-to-support-interoceptive-representations
#8
Jonathan Levy, Abraham Goldstein, Maayan Pratt, Ruth Feldman
While empathy to the pain of conspecific is evolutionary-ancient and is observed in rodents and in primates, it also integrates higher-order affective representations. Yet, it is unclear whether human empathy for pain is inborn or matures during development and what neural processes underpin its maturation. Using magnetoencephalography, we monitored the brain response of children, adolescents, and adults (n = 209) to others' pain, testing the shift from childhood to adult functioning. Results indicate that children's vicarious empathy for pain operates via rudimentary sensory predictions involving alpha oscillations in somatosensory cortex, while adults' response recruits advanced mechanisms of updating sensory predictions and activating affective empathy in viceromotor cortex via higher-level representations involving beta- and gamma-band activity...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378446/characterizing-eeg-cortical-dynamics-and-connectivity-with-responses-to-single-pulse-electrical-stimulation-spes
#9
Gonzalo Alarcón, Diego Jiménez-Jiménez, Antonio Valentín, David Martín-López
OBJECTIVES: To model cortical connections in order to characterize their oscillatory behavior and role in the generation of spontaneous electroencephalogram (EEG). METHODS: We studied averaged responses to single pulse electrical stimulation (SPES) from the non-epileptogenic hemisphere of five patients assessed with intracranial EEG who became seizure free after contralateral temporal lobectomy. Second-order control system equations were modified to characterize the systems generating a given response...
November 23, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29351559/characterisation-of-ictal-and-interictal-states-of-epilepsy-a-system-dynamic-approach-of-principal-dynamic-modes-analysis
#10
Zabit Hameed, Saqib Saleem, Jawad Mirza, Muhammad Salman Mustafa, Qamar-Ul-Islam
Epilepsy is a brain disorder characterised by the recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. The present study attempts to derive new diagnostic indices which may delineate between ictal and interictal states of epilepsy. To achieve this, the nonlinear modeling approach of global principal dynamic modes (PDMs) is adopted to examine the functional connectivity of the temporal and frontal lobes with the occipital brain segment using an ensemble of paediatric EEGs having the presence of epileptic seizure...
2018: PloS One
https://www.readbyqxmd.com/read/29341331/the-relationship-between-thalamic-gaba-content-and-resting-cortical-rhythm-in-neuropathic-pain
#11
Flavia Di Pietro, Paul M Macey, Caroline D Rae, Zeynab Alshelh, Vaughan G Macefield, E Russell Vickers, Luke A Henderson
Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others' has suggested that chronic pain that develops following nerve injury, that is, neuropathic pain, results from altered thalamocortical rhythm, although whether this dysrhythmia is associated with thalamic inhibitory function remains unknown. In this investigation, we used electroencephalography and magnetic resonance spectroscopy to investigate cortical power and thalamic GABAergic concentration in 20 patients with neuropathic pain and 20 pain-free controls...
January 17, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29339471/laminar-recordings-in-frontal-cortex-suggest-distinct-layers-for-maintenance-and-control-of-working-memory
#12
André M Bastos, Roman Loonis, Simon Kornblith, Mikael Lundqvist, Earl K Miller
All of the cerebral cortex has some degree of laminar organization. These different layers are composed of neurons with distinct connectivity patterns, embryonic origins, and molecular profiles. There are little data on the laminar specificity of cognitive functions in the frontal cortex, however. We recorded neuronal spiking/local field potentials (LFPs) using laminar probes in the frontal cortex (PMd, 8A, 8B, SMA/ACC, DLPFC, and VLPFC) of monkeys performing working memory (WM) tasks. LFP power in the gamma band (50-250 Hz) was strongest in superficial layers, and LFP power in the alpha/beta band (4-22 Hz) was strongest in deep layers...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29324406/a-novel-multi-class-eeg-based-sleep-stage-classification-system
#13
Pejman Memar, Farhad Faradji
Sleep stage classification is one of the most critical steps in effective diagnosis and the treatment of sleep-related disorders. Visual inspection undertaken by sleep experts is a time-consuming and burdensome task. A computer-assisted sleep stage classification system is thus essential for both sleep-related disorders diagnosis and sleep monitoring. In this paper, we propose a system to classify the wake and sleep stages with high rates of sensitivity and specificity. The EEG signals of 25 subjects with suspected sleep-disordered breathing, and the EEG signals of 20 healthy subjects from three data sets are used...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29321683/dual-function-of-thalamic-low-vigilance-state-oscillations-rhythm-regulation-and-plasticity
#14
REVIEW
Vincenzo Crunelli, Magor L Lőrincz, William M Connelly, François David, Stuart W Hughes, Régis C Lambert, Nathalie Leresche, Adam C Errington
During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a range of frequencies from <1 Hz slow waves to 13 Hz alpha waves. In the thalamus, these diverse activities emerge through the interaction of cell-intrinsic mechanisms and local and long-range synaptic inputs. One crucial feature, however, unifies thalamic oscillations of different frequencies: repetitive burst firing driven by voltage-dependent Ca2+ spikes...
February 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29304418/cortical-sources-of-resting-state-electroencephalographic-rhythms-probe-brain-function-in-na%C3%A3-ve-hiv-individuals
#15
Claudio Babiloni, Giuseppe Noce, Alfredo Pennica, Paolo Onorati, Paolo Capotosto, Claudio Del Percio, Paolo Roma, Valentina Correr, Elisa Piccinni, Ginevra Toma, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Elisabetta Teti, Loredana Sarmati, Gloria Crocetti, Raffaele Ferri, Valentina Catania, Maria Teresa Pascarelli, Massimo Andreoni, Stefano Ferracuti
OBJECTIVE: Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). METHODS: EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39...
December 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29298521/neural-correlates-of-phrase-quadrature-perception-in-harmonic-rhythm-an-eeg-study-using-a-brain-computer-interface
#16
Alicia Fernández-Sotos, Arturo Martínez-Rodrigo, José Moncho-Bogani, José Miguel Latorre, Antonio Fernández-Caballero
For the sake of establishing the neural correlates of phrase quadrature perception in harmonic rhythm, a musical experiment has been designed to induce music-evoked stimuli related to one important aspect of harmonic rhythm, namely the phrase quadrature. Brain activity is translated to action through electroencephalography (EEG) by using a brain-computer interface. The power spectral value of each EEG channel is estimated to obtain how power variance distributes as a function of frequency. The results of processing the acquired signals are in line with previous studies that use different musical parameters to induce emotions...
November 13, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29296618/lateral-hypothalamic-activity-indicates-hunger-and-satiety-states-in-humans
#17
Omid Talakoub, Raquel R Paiva, Matija Milosevic, Marcelo Q Hoexter, Ruth Franco, Eduardo Alho, Jessie Navarro, José F Pereira, Milos R Popovic, Cary Savage, Antonio C Lopes, Pedro Alvarenga, Durval Damiani, Manoel J Teixeira, Euripides C Miguel, Erich T Fonoff, Marcelo C Batistuzzo, Clement Hamani
Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29275174/postanoxic-alpha-theta-or-alpha-theta-coma-clinical-setting-and-neurological-outcome
#18
José L Fernández-Torre, Anjana López-Delgado, Miguel A Hernández-Hernández, Alicia Paramio-Paz, Carla Pía-Martínez, Pedro Orizaola, María Martín-García
AIM: The aim of this study was to determine the prognosis of 26 consecutive adults with alpha coma (AC), theta coma (TC) or alpha-theta coma (ATC) following CRA and to describe the clinical setting and EEG features of these patients. METHODS: We retrospective analyzed a prospectively collected cohort of adult patients diagnosed as having AC, TC or ATC after CRA between January 2008 and June 2016. None of patients included in this analysis underwent therapeutic hypothermia (TH)...
December 21, 2017: Resuscitation
https://www.readbyqxmd.com/read/29249806/cortical-high-gamma-network-oscillations-and-connectivity-a-translational-index-for-antipsychotics-to-normalize-aberrant-neurophysiological-activity
#19
A Ahnaou, H Huysmans, T Van de Casteele, W H I M Drinkenburg
Oscillatory activity in the gamma frequency range is a critical mechanism, which integrates neural networks within and across brain structures during cognitive processes. In schizophrenia, abnormalities in high gamma oscillations are ubiquitous and most likely reflect dysfunction in neuronal networks. In conscious rats, disturbed network oscillations associated with positive symptoms and cognitive deficits were modeled in different cortical areas by the dopaminergic agonist (amphetamine) and the N-methyl-D-aspartate (NMDA) receptor antagonists (PCP and MK801)...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29246552/the-use-of-del-nido-cardioplegia-in-adult-cardiac-surgery-a-prospective-randomized-trial
#20
Niv Ad, Sari D Holmes, Paul S Massimiano, Anthony J Rongione, Lisa M Fornaresio, David Fitzgerald
OBJECTIVES: The del Nido cardioplegia solution has been used extensively in congenital heart surgery for more than 20 years and more recently for adults. This randomized controlled trial examined whether expanding this technique to adult cardiac surgery confers benefits in surgical workflow and clinical outcome compared with blood-based cardioplegia. METHODS: Adult first-time coronary artery bypass grafting (CABG), valve, or CABG/valve surgery patients requiring cardiopulmonary bypass (CPB) were randomized to del Nido cardioplegia (n = 48) or whole blood cardioplegia (n = 41)...
November 13, 2017: Journal of Thoracic and Cardiovascular Surgery
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