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https://www.readbyqxmd.com/read/29790867/fluorine-18-fluorocholine-pet-ct-parameters-predictive-for-hematological-toxicity-to-radium-223-therapy-in-castrate-resistant-prostate-cancer-patients-with-bone-metastases-a-pilot-study
#1
Lavinia Vija Racaru, Mathieu Sinigaglia, Salim Kanoun, Fayçal Ben Bouallègue, Ilan Tal, Sévérine Brillouet, Mathilde Bauriaud-Mallet, Slimane Zerdoud, Lawrence Dierickx, Delphine Vallot, Olivier Caselles, Erwan Gabiache, Pierre Pascal, Frederic Courbon
PURPOSE: This study aims to predict hematological toxicity induced by Ra therapy. We investigated the value of metabolically active bone tumor volume (MBTV) and total bone lesion activity (TLA) calculated on pretreatment fluorine-18-fluorocholine (F-FCH) PET/CT in castrate-resistant prostate cancer (CRPC) patients with bone metastases treated with Ra radionuclide therapy. PATIENTS AND METHODS: F-FCH PET/CT imaging was performed in 15 patients with CRPC before treatment with Ra...
May 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29771789/raltegravir-1200-mg-once-daily-vs-400-mg-twice-daily-with-emtricitabine-and-tenofovir-disoproxil-fumarate-for-previously-untreated-hiv-1-infection-week-96-results-from-oncemrk-a-randomized-double-blind-non-inferiority-trial
#2
Pedro Cahn, Paul E Sax, Kathleen Squires, Jean-Michel Molina, Winai Ratanasuwan, Mohammed Rassool, Mark Bloch, Xia Xu, Yan Zhou, Brenda Homony, Deborah Hepler, Hedy Teppler, George J Hanna, Bach-Yen Nguyen, Wayne Greaves
BACKGROUND: Raltegravir 1200mg (2x600mg tablets) once daily (QD) demonstrated non-inferior efficacy and similar safety to raltegravir 400mg BID at Week 48 of the ONCEMRK trial. Here we report the Week 96 results from this study. METHODS: ONCEMRK is a phase 3, multicenter, double-blind, non-inferiority trial comparing raltegravir 1200mg QD to raltegravir 400mg BID in treatment-naïve HIV-1-infected adults. Participants were assigned (2:1) to raltegravir 2x600mg QD or 400mg BID, both with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) for 96 weeks...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771783/hiv-1-drug-resistance-among-ugandan-adults-attending-an-urban-out-patient-clinic
#3
Amrei von Braun, Christine Sekaggya-Wiltshire, Nadine Bachmann, Deogratius Ssemwanga, Alexandra U Scherrer, Maria Nanyonjo, Anne Kapaata, Pontiano Kaleebu, Huldrych F Günthard, Barbara Castelnuovo, Jan Fehr, Andrew Kambugu
BACKGROUND: Little is known about prevalence of drug resistance among HIV-infected Ugandans, a setting with over 15 years of public-sector access to antiretroviral therapy (ART) and where virological monitoring was only recently introduced. SETTING: This study was conducted in the adults' out-patient clinic of the Infectious Diseases Institute, Kampala, Uganda. METHODS: HIV genotyping was performed in ART naïve patients and in treatment experienced patients on ART for ≥ six months with virological failure (≥1000 copies/mL)...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29762365/multiplex-real-time-pcr-detection-of-intestinal-protozoa-in-hiv-infected-children-in-malawi-enterocytozoon-bieneusi-is-common-and-associated-with-gastrointestinal-complaints-and-may-delay-bmi-nutritional-status-recovery
#4
Minke H W Huibers, Peter Moons, Nelson Maseko, Monfort B Gushu, Oluwadamilola H Iwajomo, Robert S Heyderman, Michael Boele van Hensbroek, Eric A Brienen, Lisette van Lieshout, Job C J Calis
BACKGROUND: Intestinal protozoa are common opportunistic infections in HIV patients. Longitudinal studies on either the clinical relevance, or the effect of immune reconstitution by anti-retroviral therapy on intestinal protozoan infections are children is lacking however. This study investigates prevalence and clinical relevance of intestinal protozoa in HIV-infected Malawian children prior to and during their first year of ART. METHODS: Stool samples collected at enrolment and during follow-up were tested for non-opportunistic (Giardia lamblia, Dientamoeba fragilis, Entamoeba histolytica) and opportunistic protozoa (Entroctytoon bieneusi, Encephalitozoon spp...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29762260/clinical-indications-associated-with-opioid-initiation-for-pain-management-in-ontario-canada-a-population-based-cohort-study
#5
Sachin V Pasricha, Mina Tadrous, Wayne Khuu, David N Juurlink, Muhammad M Mamdani, J Michael Paterson, Tara Gomes
Concerns over prescription opioids contributing to high levels of opioid use disorder and overdose have led policymakers and clinicians to seek means to reduce inappropriate and high-dose initial prescriptions. To inform such efforts, we sought to describe the clinical indications associated with opioid initiation and the characteristics of the initial prescriptions and patients through a retrospective population-based cohort study. Our cohort included Ontarians initiating prescription opioids for pain management between April 1, 2015, and March 31, 2016...
May 14, 2018: Pain
https://www.readbyqxmd.com/read/29762162/genetic-characterization-of-the-hiv-1-reservoir-after-vacc-4x-and-romidepsin-therapy-in-hiv-1-infected-individuals
#6
Anni Winckelmann, Vincent Morcilla, Wei Shao, Mariane H Schleimann, Jesper F Højen, Timothy E Schlub, Paul W Denton, Lars Østergaard, Ole S Søgaard, Martin Tolstrup, Sarah Palmer
OBJECTIVE: Therapeutic HIV-1 immunization followed by latency reversal has been suggested as a strategy to eradicate HIV-1. Here we investigate the phylogenetic composition of the HIV-1 regions targeted by the therapeutic HIV-1 peptide vaccine Vacc-4x in participants in a clinical trial. DESIGN: Seventeen participants on suppressive antiretroviral therapy were vaccinated with six doses of Vacc-4x followed by three doses of romidepsin. Seven study participants were selected for sequencing analysis...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29750751/the-impact-of-patient-characteristics-and-disease-specific-factors-on-first-line-treatment-decisions-for-braf-mutated-melanoma-results-from-a-european-expert-panel-study
#7
Paolo A Ascierto, Lars Bastholt, Pier F Ferrucci, Johan Hansson, Iván Márquez Rodas, Miranda Payne, Caroline Robert, Luc Thomas, Jochen S Utikal, Pascal Wolter, Amber Kudlac, Harriet Tuson, Jan McKendrick
Treatment decisions for advanced melanoma are increasingly complex and guidelines provide limited advice on how to choose between immunotherapy and targeted therapy for first-line treatment. A Delphi study was carried out to understand which patient characteristics and disease-related factors inform clinicians' choices of first-line treatment for BRAF-mutated melanoma. Twelve European melanoma specialists experienced in using immunotherapies and targeted agents participated in a double-blind two-phase Delphi study...
May 10, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29746442/community-associated-methicillin-resistant-staphylococcus-aureus-subretinal-abscess-in-a-nonbacteremic-patient-treated-with-internal-drainage-and-retinectomy
#8
Jessica F Yang, Kamal Kishore
PURPOSE: To report a case of community-associated methicillin-resistant Staphylococcus aureus subretinal abscess that continued to progress, despite intravitreal and systemic antibiotic therapy. METHODS: Retrospective chart review of a 77-year-old female patient with well-controlled diabetes mellitus who developed a left eye endophthalmitis and subretinal abscess from methicillin-resistant S. aureus colonization in the absence of any systemic focus of infection...
May 9, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29734221/long-term-trends-in-cd4-cell-counts-cd8-cell-counts-and-the-cd4-cd8-ratio-art-cohort-collaboration-art-cc-study
#9
Rachael A Hughes, Margaret T May, Kate Tilling, Ninon Taylor, Linda Wittkop, Peter Reiss, John Gill, Philipp Schommers, Dominique Costagliola, Jodie L Guest, Viviane D Lima, Antonella d'arminio Monforte, Colette Smith, Matthias Cavassini, Michael Saag, Tim R Sterling, Jonathan A C Sterne
OBJECTIVE: Model trajectories of CD4 and CD8 cell counts after starting combination antiretroviral therapy (ART), and use the model to predict trends in these counts and the CD4:CD8 ratio. DESIGN: Cohort study of antiretroviral-naïve HIV-positive adults who started ART after 1997 (ART Cohort Collaboration) with >6 months of follow-up data. METHODS: We jointly estimated CD4 and CD8 count trends and their correlation using a bivariate random effects model, with linear splines describing their population trends, and predicted the CD4:CD8 ratio trend from this model...
May 3, 2018: AIDS
https://www.readbyqxmd.com/read/29708025/the-use-of-arts-interventions-for-mental-health-and-wellbeing-in-health-settings
#10
A Jensen, L O Bonde
AIMS: This literature review aims to illustrate the variety and multitude of studies showing that participation in arts activities and clinical arts interventions can be beneficial for citizens with mental and physical health problems. The article is focused on mental health benefits because this is an emerging field in the Nordic countries where evidence is demanded from national health agencies that face an increasing number of citizens with poor mental health and a need for non-medical interventions and programmes...
April 1, 2018: Perspectives in Public Health
https://www.readbyqxmd.com/read/29702548/the-effect-of-pet-therapy-and-artist-interactions-on-quality-of-life-in-brain-tumor-patients-a-cross-section-of-art-and-medicine-in-dialog
#11
Stefan Petranek, Jennifer Pencek, Mahua Dey
With the evolution of modern medical treatment strategies, there also comes the realization that many times we reach a point where traditional goals of medical care, such as overall survival or disease-free survival, are not realistic goals for many patients facing devastating illnesses. One such disease is malignant primary brain tumors, known as malignant glioma (MG). With median survival of only 20.9 months following best available standard of care treatment strategies, including surgery, chemotherapy, radiation, and tumor treating fields, MG is one of the deadliest malignancies of the modern era...
April 27, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29698335/pediatric-veno-veno-extracorporeal-membrane-oxygenation-rescue-from-carbon-monoxide-poisoning
#12
David A Baran, Kelly Stelling, Derrick McQueen, Mark Pearson, Vaishali Shah
BACKGROUND: Carbon monoxide poisoning affects approximately 5000 children per year and can be challenging to diagnose and treat (Pediatr Emerg Med Pract. 2016;13:1-24). It is in the differential diagnosis of a patient presented with altered consciousness. Patients may look quite "pink" and well perfused, but are often in serious distress. We present the first case in the literature of carbon monoxide poisoning treated with the use of veno-veno extracorporeal membrane oxygenation (ECMO)...
April 25, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29697591/optimal-management-of-pigment-epithelial-detachments-in-eyes-with-neovascular-age-related-macular-degeneration
#13
Arshad M Khanani, David Eichenbaum, Patricio G Schlottmann, Lisa Tuomi, David Sarraf
PURPOSE: This review aimed to determine the optimal management of retinal pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD) based on review of available evidence in the literature. METHODS: A comprehensive literature review evaluates previous retrospective and prospective studies that assessed the treatment of PEDs in nAMD. RESULTS: Studies illustrated that anti-vascular endothelial growth factor (VEGF) therapy can be effective in eyes with PED secondary to nAMD...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29694527/psyche-meets-matter-body-and-personhood-in-the-medical-scientific-project-of-nise-da-silveira
#14
Felipe Sales Magaldi
In the early 1900s, Brazilian psychiatry was marked by the use of controversial treatments, like electroconvulsive therapy, psychosurgery, and insulin coma therapy. In 1946, the Brazilian physician Nise da Silveira took the front line in criticizing these treatments by setting up a creative activities studio in the National Psychiatric Center (Centro Psiquiátrico Nacional), in Rio de Janeiro. The article examines the theoretical basis for Silveira's medical-scientific project, drawing on documental sources and fieldwork with the study group at the Museum of Images from the Unconscious (Museu de Imagens do Inconsciente), maintained by her disciples...
March 2018: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29689720/early-detection-of-alzheimer-s-disease-based-on-the-patient-s-creative-drawing-process-first-results-with-a-novel-neuropsychological-testing-method
#15
Petra Heymann, Regine Gienger, Andreas Hett, Stephan Müller, Christoph Laske, Sibylle Robens, Thomas Ostermann, Ulrich Elbing
Based on the knowledge of art therapy, we developed a new neuropsychological drawing test in order to identify individuals with mild cognitive impairment (MCI) as well as dementia patients and healthy controls (HC). By observing a variety of drawing characteristics of 92 participants with a mean age of 67.7, art therapy and dementia experts discriminate HC from MCI, early dementia of the Alzheimer-type (eDAT), and moderate dementia of the Alzheimer-type (mDAT) by the process analysis of tree drawings on a digitizing tablet...
April 14, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689025/combination-therapy-of-intravitreal-ranibizumab-and-subthreshold-micropulse-photocoagulation-for-macular-edema-secondary-to-branch-retinal-vein-occlusion-6-month-result
#16
Hiroko Terashima, Hiruma Hasebe, Fumiki Okamoto, Naoki Matsuoka, Yayoi Sato, Takeo Fukuchi
PURPOSE: To determine the efficacy of the combination therapy of intravitreal ranibizumab (IVR) and 577-nm yellow laser subthreshold micropulse laser photocoagulation (SMLP) for macular edema secondary to branch retinal vein occlusion cystoid macular edema. METHODS: Retrospective, consecutive, case-control study. Forty-six eyes of 46 patients with treatment-naive branch retinal vein occlusion cystoid macular edema were enrolled. The IVR + SMLP group consisted of 22 patients who had undergone both SMLP and IVR...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29688085/music-therapy-applied-to-complex-blast-injury-in-interdisciplinary-care-a-case-report
#17
Rebecca Vaudreuil, Luis Avila, Joke Bradt, Paul Pasquina
PURPOSE: Music therapy has a long history of treating the physiological, psychological, and neurological injuries of war. Recently, there has been an increase in the use of music therapy and other creative arts therapies in the care of combat injured service members returning to the United States from Iraq and Afghanistan, especially those with complex blast-related injuries. This case report describes the role of music therapy in the interdisciplinary rehabilitation of a severely injured service member...
April 24, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29683992/the-risk-of-nephrotoxicity-in-patients-with-drug-resistant-tuberculosis-treated-with-kanamycin-capreomycin-with-or-without-concomitant-use-of-tenofovir-containing-antiretroviral-therapy
#18
R Perumal, N Abdelghani, N Naidu, N Yende-Zuma, H Dawood, K Naidoo, N Singh, N Padayatchi
BACKGROUND: The intersection of HIV and drug-resistant TB presents the challenge of managing convergent drug toxicities. METHODS: We conducted a retrospective study of adult drug-resistant TB patients treated with a kanamycin/capreomycin-based(KM) regimen, with or without concomitant ART. We estimated the incidence of nephrotoxicity (defined as an increase in serum creatinine greater than 26.5µmol, or an increase in serum creatinine to 1.5 times the baseline value, or a decline in eGFR to less than 60ml/min/1...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29683841/monotypic-low-level-hiv-viremias-during-art-are-associated-with-disproportionate-production-of-x4-virions-and-systemic-immune-activation
#19
Marta E Bull, Caroline Mitchell, Jaime Soria, Sheila Styrchak, Corey Williams-Wietzikoski, Jillian Legard, Jennifer Mckernan-Mullin, Kelli Kraft, Frankline Onchiri, Joshua Stern, Sarah Holte, Kevin J Ryan, Edward P Acosta, Alberto La Rosa, Robert W Coombs, Eduardo Ticona, Lisa M Frenkel
OBJECTIVE: During effective antiretroviral therapy (ART), low-level plasma viremias (LLV) (HIV RNA >30-1000 copies/ml) can be detected intermittently. We hypothesized that systemic inflammation is associated with LLV either as the cause or result of the production of virions from clonally expanded cells. METHODS: Prospective cohort study of HIV-infected ART-naïve Peruvians enrolled prior to ART and followed for 2 years. Plasma HIV RNA and peripheral blood mononuclear cell (PBMC) HIV DNA concentrations were quantified pre-ART from individuals whose plasma HIV RNA was ART-suppressed...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29672326/long-term-outcome-of-adenosine-a2a-receptor-antagonist-on-lower-urinary-tract-symptoms-in-male-parkinson-disease-patients
#20
Takeya Kitta, Ichiro Yabe, Yukiko Kanno, Madoka Higuchi, Mifuka Ouchi, Mio Togo, Kimihiko Moriya, Ikuko Takahashi, Masaaki Matsushima, Hidenao Sasaki, Nobuo Shinohara
OBJECTIVES: In addition to motor symptoms, bladder dysfunction is a major clinical issue in patients with Parkinson disease (PD). Istradefylline is adenosine A2A receptor antagonist approved for PD patients with wearing-off symptoms. The aim of this study was to determine the long-term effects of istradefylline on lower urinary tract symptoms (LUTSs) in PD patients. METHODS: We enrolled 14 male PD patients. The mean age of patients was 73 years (61-77 years), the Hoehn-Yahr stage was 2 (2-3), and disease duration was 9 years (3-28 years)...
April 18, 2018: Clinical Neuropharmacology
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