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serum metabolites and gut microbiota

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https://www.readbyqxmd.com/read/29740891/effects-of-gut-microbiota-and-time-of-treatment-on-tissue-levels-of-green-tea-polyphenols-in-mice
#1
Anna B Liu, Siyao Tao, Mao-Jung Lee, Qi Hu, Xiaofeng Meng, Yong Lin, Chung S Yang
The previous studies have shown that tea polyphenols are metabolized by gut microbiota. This study investigated the effect of gut microbiota on the bioavailability, tissue levels, and degradation of tea polyphenols. Mice were treated with antibiotics (ampicillin/sulfamethoxazole/trimethoprim) in drinking water and the control mice received water for 11 days, and they were given an AIN93M diet enriched with 0.32% of Polyphenon E. The levels of catechins and their metabolites (if present) in the serum, liver, urine, and fecal samples were determined by high-performance liquid chromatography...
May 8, 2018: BioFactors
https://www.readbyqxmd.com/read/29651541/monovalerin-and-trivalerin-increase-brain-acetic-acid-decrease-liver-succinic-acid-and-alter-gut-microbiota-in-rats-fed-high-fat-diets
#2
Thao Duy Nguyen, Olena Prykhodko, Frida Fåk Hållenius, Margareta Nyman
PURPOSE: Short-chain fatty acids (SCFA) are known for their anti-inflammatory properties and may also prevent against the development of metabolic diseases. This study investigated possible effects of two valeric acid esters, monovalerin (MV) and trivalerin (TV) in rats fed high-fat diets. METHODS: Four groups of rats were given a low-fat diet (LF) or a high-fat control diet (HFC) with or without supplementation of MV or TV (5 g/kg) for 3 weeks (n = 7/group)...
April 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29620942/food-withdrawal-alters-the-gut-microbiota-and-metabolome-in-mice
#3
Xiaojiao Zheng, Kejun Zhou, Yunjing Zhang, Xiaolong Han, Aihua Zhao, Jiajian Liu, Chun Qu, Kun Ge, Fengjie Huang, Brenda Hernandez, Herbert Yu, Jun Panee, Tianlu Chen, Weiping Jia, Wei Jia
Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolome. The abundance of potentially pathogenic Proteobacteria was decreased and Akkermansia muciniphila was elevated by food withdrawal in mice fed a high-fat diet (HFD)...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29559675/microbiome-metabolome-signatures-in-mice-genetically-prone-to-develop-dementia-fed-a-normal-or-fatty-diet
#4
Elena Sanguinetti, Maria Carmen Collado, Vannina G Marrachelli, Daniel Monleon, Marta Selma-Royo, Mercedes M Pardo-Tendero, Silvia Burchielli, Patricia Iozzo
Cognitive decline, obesity and gut dysfunction or microbial dysbiosis occur in association. Our aim was to identify gut microbiota-metabolomics signatures preceding dementia in genetically prone (3xtg) mice, with and without superimposed high-fat diet. We examined the composition and diversity of their gut microbiota, and serum and faecal metabolites. 3xtg mice showed brain hypometabolism typical of pre-demented stage, and lacked the physiological bacterial diversity between caecum and colon seen in controls...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29454749/microbiota-derived-indole-metabolites-promote-human-and-murine-intestinal-homeostasis-through-regulation-of-interleukin-10-receptor
#5
Erica E Alexeev, Jordi M Lanis, Daniel J Kao, Eric L Campbell, Caleb J Kelly, Kayla D Battista, Mark E Gerich, Brittany R Jenkins, Seth T Walk, Douglas J Kominsky, Sean P Colgan
Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The specific constituents of the microbiota that contribute to mucosal disease are not well defined. The authors sought to define microbial components that regulate homeostasis within the intestinal mucosa. Using an unbiased, metabolomic profiling approach, a selective depletion of indole and indole-derived metabolites was identified in murine and human colitis...
May 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29413971/-gear-mechanism-of-bariatric-interventions-revealed-by-untargeted-metabolomics
#6
Paulina Samczuk, Magdalena Luba, Joanna Godzien, Annalaura Mastrangelo, Hady Razak Hady, Jacek Dadan, Coral Barbas, Maria Gorska, Adam Kretowski, Michal Ciborowski
Mechanisms responsible for metabolic gains after bariatric surgery are not entirely clear. The purpose of this study was evaluation of metabolic changes after laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy in semi-annual follow up. The study participants were selected from obese patients with T2DM who underwent one of the mentioned bariatric procedures. Serum metabolic fingerprinting by use of liquid and gas chromatography with mass spectrometry detection was performed on samples obtained from studied patients before, one, and six months post-surgery...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29412802/high-fat-diet-stimulates-the-gut-pathogenic-microbiota-and-maintains-hepatic-injury-in-antibiotic-treated-rats
#7
Sooad Al-Daihan, Abir Ben Bacha, Abeer M Al-Dbass, Mona Awad Alonazi, Ramesa Shafi Bhat
The gut and the liver are closely linked to each other, as changes in the gut microbiota can play a significant role in the development of many liver diseases. Gut bacteria respond rapidly to changes in diet and thus can affect the liver through their metabolites. The impact of a high lipid diet on the liver in the presence of an altered gut flora modulated by ampicillin was investigated. The study was performed on 30 male Western albino rats randomly divided into 3 groups: control (phosphate buffered saline treated), group II (ampicillin 50 mg/kg for three weeks to induce microbiota alterations and fed on standard diet) and group III (same dose of ampicillin and fed on a lipid rich diet)...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29388394/composition-of-gut-microbiota-in-obese-and-normal-weight-mexican-school-age-children-and-its-association-with-metabolic-traits
#8
B E López-Contreras, S Morán-Ramos, R Villarruel-Vázquez, L Macías-Kauffer, H Villamil-Ramírez, P León-Mimila, J Vega-Badillo, F Sánchez-Muñoz, L E Llanos-Moreno, A Canizalez-Román, B Del Río-Navarro, I Ibarra-González, M Vela-Amieva, T Villarreal-Molina, A Ochoa-Leyva, C A Aguilar-Salinas, S Canizales-Quinteros
BACKGROUND: Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of gut microbiota in childhood obesity. OBJECTIVES: The aim of this study is to compare gut microbiota composition in obese and normal-weight children and to associate gut microbiota profiles with amino acid serum levels and obesity-related metabolic traits. METHODS: Microbial taxa relative abundance was determined by 16S rRNA sequencing in 67 normal-weight and 71 obese children aged 6-12 years...
December 5, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/29382834/metabolite-identification-in-fecal-microbiota-transplantation-mouse-livers-and-combined-proteomics-with-chronic-unpredictive-mild-stress-mouse-livers
#9
Bo Li, Kenan Guo, Li Zeng, Benhua Zeng, Ran Huo, Yuanyuan Luo, Haiyang Wang, Meixue Dong, Peng Zheng, Chanjuan Zhou, Jianjun Chen, Yiyun Liu, Zhao Liu, Liang Fang, Hong Wei, Peng Xie
Major depressive disorder (MDD) is a common mood disorder. Gut microbiota may be involved in the pathogenesis of depression via the microbe-gut-brain axis. Liver is vulnerable to exposure of bacterial products translocated from the gut via the portal vein and may be involved in the axis. In this study, germ-free mice underwent fecal microbiota transplantation from MDD patients and healthy controls. Behavioral tests verified the depression model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, and liquid chromatography-mass spectrometry determined the influence of microbes on liver metabolism...
January 31, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29381822/metabolomic-response-to-coffee-consumption-application-to-a-three-stage-clinical-trial
#10
M C Cornelis, I Erlund, G A Michelotti, C Herder, J A Westerhuis, J Tuomilehto
BACKGROUND: Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. OBJECTIVE: To identify individual metabolite changes in response to coffee. METHODS: We profiled the metabolome of fasting serum samples collected from a previously reported single-blinded, three-stage clinical trial. Forty-seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed four cups of coffee/day in the second month and eight cups/day in the third month...
February 12, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29380645/variations-in-diet-cause-alterations-in-microbiota-and-metabolites-that-follow-changes-in-disease-severity-in-a-multiple-sclerosis-model
#11
J E Libbey, J M Sanchez, D J Doty, J T Sim, M F Cusick, J E Cox, K F Fischer, J L Round, R S Fujinami
Multiple sclerosis (MS) is a metabolically demanding disease involving immune-mediated destruction of myelin in the central nervous system. We previously demonstrated a significant alteration in disease course in the experimental autoimmune encephalomyelitis (EAE) preclinical model of MS due to diet. Based on the established crosstalk between metabolism and gut microbiota, we took an unbiased sampling of microbiota, in the stool, and metabolites, in the serum and stool, from mice (Mus musculus) on the two different diets, the Teklad global soy protein-free extruded rodent diet (irradiated diet) and the Teklad sterilisable rodent diet (autoclaved diet)...
April 25, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29353125/relationship-between-serum-trimethylamine-n-oxide-and-exposure-to-dioxin-like-pollutants
#12
Michael C Petriello, Richard Charnigo, Manjula Sunkara, Sony Soman, Marian Pavuk, Linda Birnbaum, Andrew J Morris, Bernhard Hennig
Trimethylamine N-oxide (TMAO) is a diet and gut microbiota-derived metabolite that has been linked to cardiovascular disease risk in human studies and animal models. TMAO levels show wide inter and intra individual variability in humans that can likely be accounted for by multiple factors including diet, the gut microbiota, levels of the TMAO generating liver enzyme Flavin-containing monooxygenase 3 (FMO3) and kidney function. We recently found that dioxin-like (DL) environmental pollutants increased FMO3 expression to elevate circulating diet-derived TMAO in mice, suggesting that exposure to this class of pollutants might also contribute to inter-individual variability in circulating TMAO levels in humans...
April 2018: Environmental Research
https://www.readbyqxmd.com/read/29234392/-1-h-nmr-based-metabonomic-study-of-functional-dyspepsia-in-stressed-rats-treated-with-chinese-medicine-weikangning
#13
Yu Guo, Zhongfeng Li, Xinfeng Liu, Xiaolan Su, Yijie Li, Jiajie Zhu, Yilin Song, Ping Zhang, Jiande D Z Chen, Ruhan Wei, Jianqin Yang, Wei Wei
1 H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN). After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls. Based on1 H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29227833/vitamin-a-deficiency-in-mice-alters-host-and-gut-microbial-metabolism-leading-to-altered-energy-homeostasis
#14
Yuan Tian, Robert G Nichols, Jingwei Cai, Andrew D Patterson, Margherita T Cantorna
Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using1 H NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A- mice showed compositional as well as functional shifts compared to the microbiota from A+ mice...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29202841/the-response-of-canine-faecal-microbiota-to-increased-dietary-protein-is-influenced-by-body-condition
#15
Jia Xu, Adronie Verbrugghe, Marta Lourenço, An Cools, Daisy J X Liu, Tom Van de Wiele, Massimo Marzorati, Venessa Eeckhaut, Filip Van Immerseel, Lynn Vanhaecke, Miguel Campos, Myriam Hesta
BACKGROUND: High protein diets shift the faecal microbiota into a more unfavourable composition in obese humans. In lean dogs, higher protein consumption is accompanied with increased production of putrefactive fermentation products, whereas obese dogs have a different gut microbiota compared to lean dogs. Still, the impact of high dietary protein on gut microbiota in obese dogs remains unclear. The aim of this study was to investigate faecal microbial changes in lean and obese dogs in response to two different levels of dietary protein...
December 4, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29180991/gut-microbial-dysbiosis-is-associated-with-altered-hepatic-functions-and-serum-metabolites-in-chronic-hepatitis-b-patients
#16
Jing Wang, Yang Wang, Xu Zhang, Jiaqi Liu, Qianpeng Zhang, Yu Zhao, Jinghua Peng, Qin Feng, Jianye Dai, Shujun Sun, Yufeng Zhao, Liping Zhao, Yongyu Zhang, Yiyang Hu, Menghui Zhang
Chronic hepatitis B (CHB) is a global epidemic disease that results from hepatitis B virus (HBV) infection and may progress to severe liver failure, including liver fibrosis, cirrhosis and hepatocellular carcinoma. Previous evidence has indicated that the dysbiosis of gut microbiota occurs after liver virus infection and is associated with severe liver disease. The aim of this study is to elucidate the compositional and functional characteristics of the gut microbiota in early-stage CHB and to understand their influence on disease progression...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29178599/gut-microbiome-induced-shift-of-acetate-to-butyrate-positively-manages-dysbiosis-in-high-fat-diet
#17
Xu Si, Wenting Shang, Zhongkai Zhou, Padraig Strappe, Bing Wang, Anthony Bird, Chris Blanchard
SCOPE: A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led to insulin over-secretion and obesity symptom. To further develop this scientific point, the effect of resistant starch (RS) or exogenous acetate carried by RS (RSA) in the gut on metabolic syndrome is investigated using diet-induced obese rats. METHODS AND RESULTS: The metabonomics analysis shows that the gut of rats in the RSA group generate more butyrate in both serum and feces rather than acetate compared to the rats in RS group, indicating the conversion among metabolites, in particular from acetate to butyrate via gut microbiota...
February 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29168502/a-gut-bacterial-pathway-metabolizes-aromatic-amino-acids-into-nine-circulating-metabolites
#18
Dylan Dodd, Matthew H Spitzer, William Van Treuren, Bryan D Merrill, Andrew J Hryckowian, Steven K Higginbottom, Anthony Le, Tina M Cowan, Garry P Nolan, Michael A Fischbach, Justin L Sonnenburg
The human gut microbiota produces dozens of metabolites that accumulate in the bloodstream, where they can have systemic effects on the host. Although these small molecules commonly reach concentrations similar to those achieved by pharmaceutical agents, remarkably little is known about the microbial metabolic pathways that produce them. Here we use a combination of genetics and metabolic profiling to characterize a pathway from the gut symbiont Clostridium sporogenes that generates aromatic amino acid metabolites...
November 30, 2017: Nature
https://www.readbyqxmd.com/read/29034330/perinatal-bisphenol-a-exposure-induces-chronic-inflammation-in-rabbit-offspring-via-modulation-of-gut-bacteria-and-their-metabolites
#19
Lavanya Reddivari, D N Rao Veeramachaneni, William A Walters, Catherine Lozupone, Jennifer Palmer, M K Kurundu Hewage, Rohil Bhatnagar, Amnon Amir, Mary J Kennett, Rob Knight, Jairam K P Vanamala
Bisphenol A (BPA) accumulates in the maturing gut and liver in utero and is known to alter gut bacterial profiles in offspring. Gut bacterial dysbiosis may contribute to chronic colonic and systemic inflammation. We hypothesized that perinatal BPA exposure-induced intestinal (and liver) inflammation in offspring is due to alterations in the microbiome and colonic metabolome. The 16S rRNA amplicon sequencing analysis revealed differences in beta diversity with a significant reduction in the relative abundances of short-chain fatty acid (SCFA) producers such as Oscillospira and Ruminococcaceae due to BPA exposure...
September 2017: MSystems
https://www.readbyqxmd.com/read/29030493/intrinsic-aerobic-capacity-governs-the-associations-between-gut-microbiota-composition-and-fat-metabolism-age-dependently-in-rat-siblings
#20
Satu Pekkala, Sanna Lensu, Miriam Nokia, Sanja Vanhatalo, Lauren G Koch, Steven L Britton, Heikki Kainulainen
Host genetic factors affecting the gut microbiome play an important role in obesity, yet limited attention has been paid on the host genetic factors linked to physical fitness in modifying the microbiome. This study determined whether sibling-matched pairs of rats selectively bred for high (HCR) and low (LCR) aerobic capacity differ in their microbiome age-dependently and which taxa associate with differential in metabolism. Several taxa in young adult rats (hereafter young) linked to inherited aerobic capacity, while in older adult (hereafter old) rats most of the differences between the lines associated with body weight...
December 1, 2017: Physiological Genomics
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