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Vitamine d deficiency and atopic diseases in child

Audrey Buelo, Susannah McLean, Steven Julious, Javier Flores-Kim, Andy Bush, John Henderson, James Y Paton, Aziz Sheikh, Michael Shields, Hilary Pinnock
INTRODUCTION: Asthma attacks are responsible for considerable morbidity and may be fatal. We aimed to identify and weight risk factors for asthma attacks in children (5-12 years) in order to inform and prioritise care. METHODS: We systematically searched six databases (May 2016; updated with forward citations January 2017) with no language/date restrictions. Two reviewers independently selected studies for inclusion, assessed study quality and extracted data. Heterogeneity precluded meta-analysis...
June 5, 2018: Thorax
Carolyn Cairncross, Cameron Grant, Welma Stonehouse, Cath Conlon, Barry McDonald, Lisa Houghton, Darryl Eyles, Carlos A Camargo, Jane Coad, Pamela von Hurst
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child's recent medical history. Analysis was by multivariable logistic regression...
June 1, 2016: Nutrients
Maria A Slack, Princess U Ogbogu, Gary Phillips, Thomas A E Platts-Mills, Elizabeth A Erwin
BACKGROUND: Vitamin D deficiency has been associated with increased risk for severe asthma, challenge-proven food allergy, and severe atopic dermatitis. Vitamin D levels have not been reported in patients with eosinophilic esophagitis (EoE). OBJECTIVE: To determine levels of 25-hydroxyvitamin D in a cohort of patients with EoE. METHODS: Total serum 25-hydroxyvitamin D was measured using liquid chromatography with tandem mass spectroscopy in adults (n = 35) and children (n = 34) with EoE...
July 2015: Annals of Allergy, Asthma & Immunology
Chih-Yung Chiu, Shih-Yin Huang, Yu-Chieh Peng, Ming-Han Tsai, Man-Chin Hua, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: There are few studies addressing the impact of maternal vitamin D status on the vitamin D levels in offspring, their sensitization to common allergens and atopic disease development. METHODS: Children aged 0 through 4 yr from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Time series of serum 25-hydroxyvitamin D (25(OH)D) levels were measured in maternal blood before delivery, cord blood, and at age 1...
June 2015: Pediatric Allergy and Immunology
Carlos A Camargo, D Ganmaa, Robert Sidbury, Kh Erdenedelger, N Radnaakhand, B Khandsuren
BACKGROUND: Epidemiologic and preclinical data, and a small randomized trial in Boston, suggest that vitamin D supplementation may improve winter-related atopic dermatitis (AD). OBJECTIVE: To determine the effect of vitamin D supplementation on winter-related AD. METHODS: We performed a randomized, double-blind, placebo-controlled trial of Mongolian children with winter-related AD ( identifier: NCT00879424). Baseline eligibility included age 2 to 17 years, AD score 10 to 72 using the Eczema Area and Severity Index (EASI), and winter-related AD (eg, history of AD worsening during the fall-to-winter transition)...
October 2014: Journal of Allergy and Clinical Immunology
Susan Shuxin Wang, Kam Lun Hon, Alice Pik-shan Kong, Henry Nga-hin Pong, Gary Wing-kin Wong, Ting Fan Leung
BACKGROUND: Recent studies implicated the importance of vitamin D in innate immune defense and pathogenesis of allergic diseases. However, the impact of vitamin D deficiency on atopic dermatitis (AD) diagnosis and severity remains unclear. This case-control study investigated such relationship in Hong Kong Chinese children. METHODS: Serum 25-hydroxyvitamin D [25(OH)D] levels of 498 AD children and 328 non-allergic controls were measured by immunoassay. Subjects were categorized into deficient (< 25 nm), insufficient (25-49...
February 2014: Pediatric Allergy and Immunology
Moustafa A El Taieb, Hanan M Fayed, Sanaa S Aly, Ahmed K Ibrahim
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an immunologic basis. It may have negative medical and social impacts on a patient and his family. OBJECTIVES: To assess serum level of vitamin D among children with AD and determine its association with AD severity using the AD Scoring System Index. STUDY DESIGN: A case-control study. PATIENTS AND METHODS: Twenty-nine patients with AD in the age group between 2 and 12 years were enrolled in the study...
November 2013: Dermatitis
Arturo Borzutzky, Carlos A Camargo
Atopic dermatitis (AD) is a highly prevalent allergic skin disease that affects children worldwide. Epidemiological, clinical and basic immunological studies have suggested an association between vitamin D (VD) deficiency and the development of AD and other allergic diseases. Low levels of VD, a pleiotropic hormone that has widespread effects on the immune system and skin integrity, appear to be inversely correlated with AD severity, and VD deficiency at birth is associated with higher risk of developing AD...
August 2013: Expert Review of Clinical Immunology
Krishna Mutgi, John Koo
Atopic dermatitis (AD) is a common chronic inflammatory type of eczema. The underlying cause of AD has not been established. Several studies have shown initial epidermal barrier dysfunction with subsequent immune activation as the underlying mechanism. Recently, in addition to its classical role in calcium homeostasis, vitamin D has been recognized for its effect on immunomodulation. Animal studies, case reports, and randomized clinical trials have suggested that vitamin D, through various mechanisms, may alleviate the symptoms of AD...
May 2013: Pediatric Dermatology
John M Brehm, Edna Acosta-Pérez, Lambertus Klei, Kathryn Roeder, Michael Barmada, Nadia Boutaoui, Erick Forno, Roxanne Kelly, Kathryn Paul, Jody Sylvia, Augusto A Litonjua, Michael Cabana, María Alvarez, Angel Colón-Semidey, Glorisa Canino, Juan C Celedón
RATIONALE: Vitamin D insufficiency (a serum 25(OH)D <30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin D and asthma in Puerto Ricans. OBJECTIVES: To examine whether vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, and time outdoors. METHODS: A cross-sectional study was conducted of 560 children ages 6-14 years with (n = 287) and without (n = 273) asthma in San Juan, Puerto Rico...
July 15, 2012: American Journal of Respiratory and Critical Care Medicine
Diego G Peroni, Beatrice Bonomo, Serena Casarotto, Attilio L Boner, Giorgio L Piacentini
The increasing prevalence of allergic diseases in childhood in the last decades could be linked to concomitant dietary changes, especially with the modified and lower consumption of fruit, vegetables and minerals. The consumption of these foods by pregnant women and children in the first years of life seems to be associated with a reduced risk of asthma and related symptoms. Foods that can prevent the development of wheezing through their antioxidant effects contain vitamin C and selenium; blood levels of these elements correlate negatively with the risk of wheezing...
2012: Italian Journal of Pediatrics
M S Ehlayel, A Bener, A Sabbah
BACKGROUND: Studies suggest a link between vitamin D deficiency and development of asthma and allergic diseases. AIM: To determine a) the association between vitamin D and asthma among children, b) difference in level of vitamin D in asthmatic children and control, and c) effect of vitamin D on atopy markers. SETTING: Case-control study done, between October 2009 to July 2010, on asthmatics and controls (< 15 years) at Pediatric Allergy-Immunology Clinics and Primary Health care Clinics (PHC), Qatar...
June 2011: European Annals of Allergy and Clinical Immunology
Shimi Sharief, Sunit Jariwala, Juhi Kumar, Paul Muntner, Michal L Melamed
BACKGROUND: Previous research supports a possible link between low vitamin D levels and atopic disease. However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied. OBJECTIVE: We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006...
May 2011: Journal of Allergy and Clinical Immunology
D G Peroni, G L Piacentini, E Cametti, I Chinellato, A L Boner
BACKGROUND: Vitamin D deficiency could be associated with the prevalence of atopic dermatitis (AD). OBJECTIVES: We carried out a study to see whether deficient/insufficient levels of vitamin D correlate with the severity of atopic skin disease. METHODS: Using the SCORAD index, we evaluated the severity of disease in 37 children (17 girls and 20 boys) aged between 8 months and 12 years with AD, consecutively enrolled in the study. Serum levels of 25-hydroxyvitamin D [25(OH)D] were determined by a chemiluminescent method...
May 2011: British Journal of Dermatology
Milo F Vassallo, Aleena Banerji, Susan A Rudders, Sunday Clark, Raymond J Mullins, Carlos A Camargo
BACKGROUND: The prevalence of food allergy is rising, and etiologic factors remain uncertain. Evidence implicates a role for vitamin D in the development of atopic diseases. Based on seasonal patterns of UV-B exposure (and consequent vitamin D status), we hypothesized that patients with food allergy are more often born in fall or winter. OBJECTIVE: To investigate whether season of birth is associated with food allergy. METHODS: We performed a multicenter medical record review of all patients presenting to 3 Boston emergency departments (EDs) for food-related acute allergic reactions between January 1, 2001, and December 31, 2006...
April 2010: Annals of Allergy, Asthma & Immunology
S M Willers, G Devereux, L C A Craig, G McNeill, A H Wijga, W Abou El-Magd, S W Turner, P J Helms, A Seaton
BACKGROUND: Associations between maternal vitamin E, vitamin D and zinc intakes during pregnancy and asthma, wheeze and eczema in 5-year-old children have previously been reported. A study was undertaken to investigate whether maternal intake of specific foods during pregnancy is associated with asthma and allergic outcomes in the same children. METHODS: A longitudinal birth cohort study was conducted in 1,924 children born to women recruited during pregnancy. Maternal diet during pregnancy was assessed by food frequency questionnaire (FFQ)...
September 2007: Thorax
Joyce W Yu, Gary Pekeles, Laurent Legault, Christine T McCusker
BACKGROUND: Cow's milk allergy is one of the most common allergies in infancy. It has an excellent prognosis since most cases resolve by 4 years of age. The complications associated with milk allergy include delayed growth and atopic conditions, such as asthma, allergic rhinitis, atopic dermatitis, and other food allergies. OBJECTIVE: To report a case of vitamin D deficiency rickets in a 2-year-old boy with cow's milk allergy. METHODS: We describe a patient with clinical and biochemical evidence of rickets, including decreased serum calcium, phosphate, and 25-hydroxy vitamin D levels and an elevated alkaline phosphatase level...
April 2006: Annals of Allergy, Asthma & Immunology
C Bodner, D Godden, K Brown, J Little, S Ross, A Seaton
An increase in prevalence of wheezing illness in the UK has coincided with a reduction in the consumption of natural antioxidants, which may modulate the lung's response to oxidant stress, limiting the expression of airway inflammation and respiratory symptoms. The hypothesis that intakes and plasma levels of natural antioxidants would be determinants of adult-onset wheezing illness was tested. A nested case-control study was conducted in 94 cases with adult-onset wheeze and 203 controls aged 39-45 yrs identified in a 30-yr follow-up survey...
January 1999: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
J Z Yetiv
Fish oil supplements are currently being nationally advertised, and many physicians are being queried about their clinical utility. Epidemiologic studies reveal a low incidence of cardiovascular disease in people, such as the Eskimos, who eat large amounts of seafood. Cardiovascular health may be improved because fish and fish oil supplements lower plasma lipid levels (especially triglycerides), inhibit platelet aggregation, and may decrease blood pressure and viscosity and increase high-density lipoprotein (HDL) levels...
August 5, 1988: JAMA: the Journal of the American Medical Association
T J David
Short stature, defined as a standing height below the third centile when corrected for mid-parental height, was found in 22% of children with atopic eczema troublesome enough to cause regular attendance at hospital. The cause of this short stature is unknown in most cases, but contributory factors comprise topical steroid therapy, co-existing asthma, inhaled or oral steroid therapy, malnutrition due to unsupervised dietary restriction, loss of sleep, and vitamin D deficiency. If the short stature is simply associated with severe disease and not attributable to steroid therapy, and if the disease remits before puberty, then catch-up growth can be expected...
1989: Acta Dermato-venereologica. Supplementum
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