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Mir-223

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https://www.readbyqxmd.com/read/27916606/fbx8-is-a-metastasis-suppressor-downstream-of-mir-223-and-targeting-mtor-for-degradation-in-colorectal-cancer
#1
F F Wang, X J Zhang, Y R Yan, X H Zhu, J Yu, Y Ding, J L Hu, W J Zhou, Z C Zeng, W T Liao, Y Q Ding, L Liang
F-box proteins are critical components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases and involved in the ubiquitin-dependent proteolytic pathway. Dysregulation of F-box protein-mediated proteolysis often leads to human malignancies. F-box only protein 8 (FBX8), a novel component of F-box proteins, is down-regulated in several tumors and closely correlates with tumor progression. However, little is known about its function, regulatory mechanisms and substrates in the progression of colorectal cancer (CRC)...
December 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27908272/exosome-encapsulated-micrornas-as-potential-circulating-biomarkers-in-colon-cancer
#2
Mina Hosseini, Sara Khatamianfar, Seyed Mahdi Hassanian, Reza Nedaeinia, Mojtaba Shafiee, Mina Maftouh, Majid Ghayour-Mobarhan, Soudabeh Shahid Sales, Amir Avan
Exosome-encapsulated microRNAs are being suggested as a new class novel biomarker and diagnostic and predictive markers in colorectal cancer. These particles are released from many cell types into the extracellular space upon fusion of multivesicular bodies (MVB) with the plasma membrane. They contain a wide variety of information, including proteins, lipids, RNAs, non-transcribed RNAs, microRNAs, which can be circulated in various body fluids (e.g., blood, salvia, ascites, urine). Exosomes can be taken up by neighboring or distant cells and thereby modulate the functional of recipient cells and play a key role in disease progression or facilitate metastasis in cancers...
December 1, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27900032/mir-223-decreases-cell-proliferation-and-enhances-cell-apoptosis-in-acute-myeloid-leukemia-via-targeting-fbxw7
#3
Yi Xiao, Changliang Su, Taoran Deng
The expression of microRNA-223 (miR-233) has been investigated in various types of cancer. However, to the best of our knowledge, the expression and function of miR-223 in acute myeloid leukemia (AML) remains to be elucidated. The expression of miR-223 was measured by reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-223, cell viability assays, cell apoptosis assays, western blot analysis and luciferase assays were conducted in AML cell lines. In the present study, it was initially observed that miR-223 was downregulated in AML patients compared with healthy subjects...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27884727/impact-of-17beta-estradiol-and-progesterone-on-inflammatory-and-apoptotic-microrna-expression-after-ischemia-in-a-rat-model
#4
Rebecca Herzog, Adib Zendedel, Leoni Lammerding, Cordian Beyer, Alexander Slowik
17β-estradiol (E2) and progesterone (P) are neuroprotective factors in the brain preventing neuronal death under different injury paradigms. In previous studies, we demonstrated that both steroids dampen neuronal damage, improve local energy metabolism and attenuate pro-inflammatory responses. MicroRNAs (miRNAs) are small regulators of distinct target genes on the RNA level. Their expression patterns are misbalanced in several neurological disorders. To explore the regulatory mechanisms of steroid hormones on selected miRNAs and their validated targets in ischemia, we used the transient middle cerebral artery occlusion (tMCAO) model...
November 22, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27870736/lidocaine-administration-controls-micrornas-alterations-observed-after-lung-ischemia-reperfusion-injury
#5
Lisa Rancan, Carlos Simón, Emmeline Marchal-Duval, Javier Casanova, Sergio Damian Paredes, Alberto Calvo, Cruz García, David Rincón, Agustín Turrero, Ignacio Garutti, Elena Vara
BACKGROUND: Ischemia-reperfusion injury (IRI) is associated with morbidity and mortality. MicroRNAs (miRNAs) have emerged as regulators of IRI, and they are involved in the pathogenesis of organ rejection. Lidocaine has proven anti-inflammatory activity in several tissues but its modulation of miRNAs has not been investigated. This work aims to investigate the involvement of miRNAs in lung IRI in a lung auto-transplantation model and to investigate the effect of lidocaine. METHODS: Three groups (sham, control, and Lidocaine), each comprising 6 pigs, underwent a lung autotransplantation...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27869909/altered-levels-of-circulating-cytokines-and-micrornas-in-lean-and-obese-individuals-with-prediabetes-and-type-2-diabetes
#6
Yury O Nunez Lopez, Gabriella Garufi, Attila A Seyhan
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions. However, our current understanding of the primary mechanisms leading to these diseases is still limited due to the complex multifactorial nature of the underlying phenomena. We hypothesize that the levels of specific cytokines and miRNAs vary across the diabetes spectrum and unique signatures associated with them may serve as early biomarkers of the disease and provide insights into respective pathogenetic mechanisms. In this study, we measured the circulating levels of cytokines and microRNAs (miRNAs) in lean and obese humans with prediabetes (n = 21), T2D (n = 17), and healthy controls (n = 20) (ORIGINS trial, NCT02226640)...
November 21, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27866993/micrornas-223-3p-and-93-5p-in-patients-with-chronic-kidney-disease-before-and-after-renal-transplantation
#7
M Ulbing, A H Kirsch, B Leber, S Lemesch, J Münzker, N Schweighofer, D Hofer, O Trummer, A R Rosenkranz, H Müller, K Eller, V Stadlbauer, B Obermayer-Pietsch
Chronic kidney disease (CKD) is associated with a multifactorial dysregulation of bone and vascular calcification and closely linked to increased cardiovascular mortality and concomitant bone disease. We aimed to investigate specific microRNA (miRNA) signatures in CKD patients to find indicators for vascular calcification and/or bone mineralization changes during CKD and after kidney transplantation (KT). A miRNA array was used to investigate serum miRNA profiles in CKD patients, then selected miRNAs were quantified in a validation cohort comprising 73 patients in CKD stages 3 to 5, 67 CKD patients after KT, and 36 healthy controls...
November 17, 2016: Bone
https://www.readbyqxmd.com/read/27812198/visceral-adipose-microrna-223-is-upregulated-in-human-and-murine-obesity-and-modulates-the-inflammatory-phenotype-of-macrophages
#8
Jeffrey A Deiuliis, Rafay Syed, Dheeraj Duggineni, Jessica Rutsky, Palanivel Rengasamy, Jie Zhang, Kun Huang, Bradley Needleman, Dean Mikami, Kyle Perry, Jeffrey Hazey, Sanjay Rajagopalan
Obesity in humans and mice is typified by an activated macrophage phenotype in the visceral adipose tissue (VAT) leading to increased macrophage-mediated inflammation. microRNAs (miRNAs) play an important role in regulating inflammatory pathways in macrophages, and in this study we compared miRNA expression in the VAT of insulin resistant morbidly obese humans to a non-obese cohort with normal glucose tolerance. miR-223-3p was found to be significantly upregulated in the whole omental tissue RNA of 12 human subjects, as were 8 additional miRNAs...
2016: PloS One
https://www.readbyqxmd.com/read/27806914/micrornas-in-the-pathophysiology-of-ckd-mbd-biomarkers-and-innovative-drugs
#9
REVIEW
Valérie Metzinger-Le Meuth, Stéphane Burtey, Pierre Maitrias, Ziad A Massy, Laurent Metzinger
microRNAs comprise a novel class of endogenous small non-coding RNAs that have been shown to be implicated in both vascular damage and bone pathophysiology. Chronic kidney disease-mineral bone disorder (CKD-MBD) is characterized by vessel and bone damage secondary to progressive loss of kidney function. In this review, we will describe how several microRNAs have been implicated, in recent years, in cellular and animal models of CKD-MBD, and have been very recently shown to be deregulated in patients with CKD...
October 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27777110/altered-expression-of-mirnas-in-the-uterus-from-a-letrozole-induced-rat-pcos-model
#10
Chunjin Li, Lu Chen, Yun Zhao, Shuxiong Chen, Lulu Fu, Yanwen Jiang, Shan Gao, Zhuo Liu, Fengge Wang, Xiaoling Zhu, Jiahui Rao, Jing Zhang, Xu Zhou
Polycystic ovary syndrome (PCOS) causes female subfertility with ovarian disorders and may be associated with increased rate of early-pregnancy failure. Rat PCOS models were established using letrozole to understand the uterine pathogenesis of PCOS. The differential expression of microRNAs (miRNAs) was observed in rat uterus with PCOS. After estrous cycles were disrupted, significantly abnormal ovarian morphology and hormone level were observed in rats with PCOS. A total of 148 miRNAs differentially expressed were identified in the uterus from the letrozole-induced rat model compared with the control...
October 21, 2016: Gene
https://www.readbyqxmd.com/read/27756518/intracellular-and-extracellular-mirnome-deregulation-in-cellular-models-of-nafld-or-nash-clinical-implications
#11
S Di Mauro, M Ragusa, F Urbano, A Filippello, A Di Pino, A Scamporrino, A Pulvirenti, A Ferro, A M Rabuazzo, M Purrello, F Purrello, S Piro
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD has the potential to progress through the inflammatory phase of nonalcoholic steatohepatitis (NASH) to fibrosis, cirrhosis, and hepatocellular carcinoma. Identifying patients at risk for this transition is a relevant clinical challenge. The complexity of these phenotypes in vivo made necessary the development of in vitro models in order to dissect the molecular signalling affected in NAFLD and NASH, but also to identify potential circulating biomarkers...
December 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27749761/microrna-expression-profiling-of-macrophage-line-raw264-7-infected-by-candida-albicans
#12
Chuan-Xin Wu, Jing Cheng, Yun-Ying Wang, Jiao-Jiao Wang, Hui Guo, Hang Sun
INTRODUCTION: The aim of this study was to clarify the miRNA expression profiles of RAW264.7 macrophages infected by Candida albicans to elucidate the roles of differentially expressed miRNAs and to further explore the mechanisms underlying the immune response to C. albicans infection. METHODS: High-throughput miRNA microarray analysis was performed to detect differentially expressed miRNAs in control and C. albicans-infected RAW264.7 cells. Quantitative real-time PCR analysis was used to verify the microarray results...
October 5, 2016: Shock
https://www.readbyqxmd.com/read/27744452/ginkgolide-b-inhibits-human-bladder-cancer-cell-migration-and-invasion-through-microrna-223-3p
#13
Yi Zhi, Jinhong Pan, Wenhao Shen, Peng He, Ji Zheng, Xiaozhou Zhou, Gensheng Lu, Zhiwen Chen, Zhansong Zhou
BACKGROUND/AIMS: Ginkgolide B (GB) is currently used as an anticancer drug for treatment of some malignant cancers. However, whether it may have therapeutic effects on bladder cancer remains unknown. Here, we studied the effects of GB on bladder cancer cells. METHODS: Bladder cells were treated with different doses of GB, and the effects on ZEB1 and microRNA-223-3p (miR-223-3p) were analyzed by RT-qPCR and/or Western blot. Prediction of a regulatory relationship between miR-93 and 3'-UTR of Beclin-1 mRNA was performed by a bioinformatics algorithm and confirmed by a dual luciferase reporter assay...
October 17, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27725128/effect-of-fingolimod-treatment-on-circulating-mir-15b-mir23a-and-mir-223-levels-in-patients-with-multiple-sclerosis
#14
Chiara Fenoglio, Milena De Riz, Anna M Pietroboni, Alberto Calvi, Maria Serpente, Sara M G Cioffi, Marina Arcaro, Emanuela Oldoni, Elio Scarpini, Daniela Galimberti
MicroRNAs (miRNAs) have recently found to be dysregulated in serum from multiple sclerosis (MS) patients. Cell free circulating miR-15b, -23a and 223 levels were analyzed by Real Time PCR in a cohort consisting of 30 serum samples from Relapsing Remitting MS patients at baseline (T0) and after three, six, nine and twelve months (T1, T2, T3, T4) after starting the treatment. A down-regulation of miRNA levels in patients at T0 compared with controls was present (p<0.001). MiRNA levels slightly increased at T1 and this trend reached the statistical significance at T2 vs T0 and remains stable at T3 and T4...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27708120/commercial-dairy-cow-milk-micrornas-resist-digestion-under-simulated-gastrointestinal-tract-conditions
#15
Abderrahim Benmoussa, Chan Ho C Lee, Benoit Laffont, Patricia Savard, Jonathan Laugier, Eric Boilard, Caroline Gilbert, Ismail Fliss, Patrick Provost
BACKGROUND: MicroRNAs are small, gene-regulatory noncoding RNA species present in large amounts in milk, where they seem to be protected against degradative conditions, presumably because of their association with exosomes. OBJECTIVE: We monitored the relative stability of commercial dairy cow milk microRNAs during digestion and examined their associations with extracellular vesicles (EVs). METHODS: We used a computer-controlled, in vitro, gastrointestinal model TNO intestinal model-1 (TIM-1) and analyzed, by quantitative polymerase chain reaction, the concentration of 2 microRNAs within gastrointestinal tract compartments at different points in time...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27704586/hypermethylation-of-prdm1-blimp-1-promoter-in-extranodal-nk-t-cell-lymphoma-nasal-type-an-evidence-of-predominant-role-in-its-downregulation
#16
Zhang Zhang, Li Liang, Dong Li, Lin Nong, Jumei Liu, Linlin Qu, Yalin Zheng, Bo Zhang, Ting Li
The loss of PRDM1 expression is common in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT), but the role of promoter methylation in silencing PRDM1 expression remains unclear. Hence, we performed pyrosequencing analysis to evaluate the promoter methylation of PRDM1 gene in vivo and in vitro, to analyze the association between methylation and its expression, and to assess cellular effects of PRDM1 reexpression. The promoter hypermethylation of PRDM1 gene was detected in 11 of 25 EN-NK/T-NT cases (44.0%) and NK92 and NKL cells...
October 5, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27704281/mir-223-regulates-the-number-and-function-of-myeloid-derived-suppressor-cells-in-multiple-sclerosis-and-experimental-autoimmune-encephalomyelitis
#17
Claudia Cantoni, Francesca Cignarella, Laura Ghezzi, Bob Mikesell, Bryan Bollman, Melissa M Berrien-Elliott, Aaron R Ireland, Todd A Fehniger, Gregory F Wu, Laura Piccio
Myeloid-derived cells play important modulatory and effector roles in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells, composed of monocytic (MO) and polymorphonuclear (PMN) fractions, which can suppress T cell activities in EAE. Their role in MS remains poorly characterized. We found decreased numbers of circulating MDSCs, driven by lower frequencies of the MO-MDSCs, and higher MDSC expression of microRNA miR-223 in MS versus healthy subjects...
October 4, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27695455/tissue-specific-expression-patterns-of-microrna-during-acute-graft-versus-host-disease-in-the-rat
#18
Dasaradha Jalapothu, Margherita Boieri, Rachel E Crossland, Pranali Shah, Isha A Butt, Jean Norden, Ralf Dressel, Anne M Dickinson, Marit Inngjerdingen
MicroRNAs (miRNA) have emerged as central regulators of diverse biological processes and contribute to driving pathology in several diseases. Acute graft-versus-host disease (aGvHD) represents a major complication after allogeneic hematopoietic stem cell transplantation, caused by alloreactive donor T cells attacking host tissues leading to inflammation and tissue destruction. Changes in miRNA expression patterns occur during aGvHD, and we hypothesized that we could identify miRNA signatures in target tissues of aGvHD that may potentially help understand the underlying molecular pathology of the disease...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27679493/microrna-223-ameliorates-alcoholic-liver-injury-by-inhibiting-the-il-6-p47phox-oxidative-stress-pathway-in-neutrophils
#19
Man Li, Yong He, Zhou Zhou, Teresa Ramirez, Yueqiu Gao, Yanhang Gao, Ruth A Ross, Haixia Cao, Yan Cai, Mingjiang Xu, Dechun Feng, Ping Zhang, Suthat Liangpunsakul, Bin Gao
OBJECTIVES: Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral neutrophils and liver injury in alcoholics, and how miR-223, one of the most abundant microRNAs (miRNAs) in neutrophils, modulates neutrophil function and liver injury in ethanol-fed mice. DESIGNS: Three hundred alcoholics with (n=140) or without (n=160) recent excessive drinking and 45 healthy controls were enrolled...
September 27, 2016: Gut
https://www.readbyqxmd.com/read/27661412/use-of-biomarkers-to-establish-potential-role-and-function-of-circulating-micrornas-in-acute-heart-failure
#20
Eline L Vegter, Daniela Schmitter, Yanick Hagemeijer, Ekaterina S Ovchinnikova, Pim van der Harst, John R Teerlink, Christopher M O'Connor, Marco Metra, Beth A Davison, Daniel Bloomfield, Gad Cotter, John G Cleland, Michael M Givertz, Piotr Ponikowski, Dirk J van Veldhuisen, Peter van der Meer, Eugene Berezikov, Adriaan A Voors, Mohsin A F Khan
BACKGROUND: Circulating microRNAs (miRNAs) emerge as potential heart failure biomarkers. We aimed to identify associations between acute heart failure (AHF)-specific circulating miRNAs and well-known heart failure biomarkers. METHODS: Associations between 16 biomarkers predictive for 180day mortality and the levels of 12 AHF-specific miRNAs were determined in 100 hospitalized AHF patients, at baseline and 48hours. Patients were divided in 4 pre-defined groups, based on clinical parameters during hospitalization...
September 11, 2016: International Journal of Cardiology
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