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https://www.readbyqxmd.com/read/28745143/high-fat-simple-carbohydrate-hfsc-diet-impairs-hypothalamic-and-corpus-striatal-serotonergic-metabolic-pathway-in-metabolic-syndrome-mets-induced-c57bl-6j-mice
#1
DSouza Serena Stephen, Asha Abraham
OBJECTIVES: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. METHODS: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector...
July 26, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28728347/pros-and-cons-of-health-transformation-program-in-iran-evidence-from-financial-outcomes-at-household-level
#2
Enayatollah Homaie Rad, Vahid Yazdi-Feyzabadi, Shahrokh Yousefzadeh-Chabok, Abolhasan Afkar, Ahmad Naghibzadeh Tahami
Purpose: Health transformation program (HTP) is one of the recent reforms in health system of Iran implemented in early 2014. Improving the equity of payments and reducing out of pocket (OOP) and catastrophic health expenditures (CHE) were some of the program's important goals. In this study these goals were evaluated using a before-after analysis. Methods: Household income and expenditures data of Guilan province were gathered for years 2013-2015. OOP payments for outpatient, inpatient and drug services were calculated and the results were compared using propensity score matching technique after adjustment of confounding variables...
July 18, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28724067/multitrait-random-regression-or-simple-repeatability-model-in-high-throughput-phenotyping-data-improve-genomic-prediction-for-wheat-grain-yield
#3
Jin Sun, Jessica E Rutkoski, Jesse A Poland, José Crossa, Jean-Luc Jannink, Mark E Sorrells
High-throughput phenotyping (HTP) platforms can be used to measure traits that are genetically correlated with wheat ( L.) grain yield across time. Incorporating such secondary traits in the multivariate pedigree and genomic prediction models would be desirable to improve indirect selection for grain yield. In this study, we evaluated three statistical models, simple repeatability (SR), multitrait (MT), and random regression (RR), for the longitudinal data of secondary traits and compared the impact of the proposed models for secondary traits on their predictive abilities for grain yield...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28709369/deposition-and-light-absorption-characteristics-of-precipitation-dissolved-organic-carbon-doc-at-three-remote-stations-in-the-himalayas-and-tibetan-plateau-china
#4
Chaoliu Li, Fangping Yan, Shichang Kang, Pengfei Chen, Zhaofu Hu, Xiaowen Han, Guoshuai Zhang, Shaopeng Gao, Bin Qu, Mika Sillanpää
The concentrations, depositions and optical properties of precipitation DOC at three remote stations (Nam Co, Lulang and Everest) were investigated in the Himalayas and Tibetan Plateau (HTP). The results showed that their volume-weighted mean DOC concentrations were 1.05±1.01mgCL(-1), 0.83±0.85mgCL(-1) and 0.86±0.91mgCL(-1), respectively, close to those of other remote areas in the world and lower than those of typical polluted urban cities. Combined with precipitation amounts, the DOC depositions at these three stations were calculated to be 0...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28686023/phoxi-a-high-quantum-yield-solvent-sensitive-blue-fluorescent-5-hydroxytryptophan-derivative-synthesized-within-ten-minutes-under-aqueous-ambient-conditions
#5
Alexandre Grigoryan, Azaria S Eisenberg, Laura J Juszczak
Multiple tryptophan (Trp) proteins are not amenable to fluorescence study because individual residue emission is not resolvable. Biosynthetic incorporation of an indole analogue such as 5-hydroxyindole has not provided sufficient spectroscopic resolution because of low quantum yield and small emission shift. Here, 5-hydroxyindole is used as the starting framework for building a blue emitting fluorophore of high quantum yield, 2-phenyl-6H-oxazolo[4,5-e]indole (PHOXI). This is a three reagent reaction completed in 10 min under ambient conditions in borate buffer at pH 8...
July 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28677038/arsenate-removal-from-aqueous-solution-by-siderite-synthesized-under-high-temperature-and-high-pressure
#6
Zhilin Yang, Wei Xiu, Huaming Guo, Fulan Li
In present study, a novel method was developed to synthesize siderite under high temperature and high pressure (SID-HTP). SID-HTP was characterized by N2 adsorption-desorption isotherms (BET), XRD, SEM, and FTIR and utilized to remove arsenic(V) (As(V)) from aqueous solution. Results showed that, under oxic condition, pH had ignorable effect on As(V) adsorption. However, adsorption capacity increased with increasing pH from 2 to 7 and remained relatively constant at higher pH until 10 under anoxic condition...
July 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28671157/primary-hyperparathyroidism-in-pregnancy
#7
Meryem Rchachi, Hanan El Ouahabi, Saïd Boujraf, Farida Ajdi
Primary hyperparathyroidism (PHT) is a frequent and asymptomatic pathology in 80% of patients, and a parathyroidal adenoma is found in the most case. However, rare cases might occur during pregnancy; and the literature reported up to 200 cases. We report three cases of PHT that occurred during the second and last third trimesters of pregnancy stage in patients aged 26, 42 and 32-year-old. Despite diagnosis limitations, since scintigraphy is prohibited in pregnancy, the patients were managed conservatively with good prognosis for both mothers and babies...
July 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28601766/trace-level-determination-of-5-hydroxytryptamine-and-its-related-indoles-in-amniotic-fluid-by-gas-chromatography-mass-spectrometry
#8
Hongmei Shi, Bo Wang, Lingmei Niu, Mengsi Cao, Weijun Kang, Kaoqi Lian, Pingping Zhang
5-hydroxytryptamine (5-HT) and its derivatives are endogenously active substances involved in multiple physiological and pathological processes. A novel method of detetermining 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-HT in amniotic fluid by gas chromatography-mass spectrometry (GC-MS) was established based on a modified method of derivatization by silanization, in combination with solid-phase extraction pretreatment. Good linearity was achieved in the tested calibration range...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28600943/investigating-hydrothermal-pretreatment-of-food-waste-for-two-stage-fermentative-hydrogen-and-methane-co-production
#9
Lingkan Ding, Jun Cheng, Dan Qiao, Liangchen Yue, Yu-You Li, Junhu Zhou, Kefa Cen
The growing amount of food waste (FW) in China poses great pressure on the environment. Complex solid organics limit the hydrolysis of FW, hence impairing anaerobic digestion. This study employed hydrothermal pretreatment (HTP) to facilitate the solubilization of FW. When HTP temperature increased from 100 to 200°C, soluble carbohydrate content first increased to a peak at 140°C and then decreased, whereas total carbohydrate content was negatively correlated with increasing temperature due to the enhanced degradation and Maillard reactions...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28574702/high-throughput-platform-for-synthesis-of-melamine-formaldehyde-microcapsules
#10
Seda Çakir, Erwin Bauters, Guadalupe Rivero, Tom Parasote, Johan Paul, Filip E Du Prez
The synthesis of microcapsules via in situ polymerization is a labor-intensive and time-consuming process, where many composition and process factors affect the microcapsule formation and its morphology. Herein, we report a novel combinatorial technique for the preparation of melamine-formaldehyde microcapsules, using a custom-made and automated high-throughput platform (HTP). After performing validation experiments for ensuring the accuracy and reproducibility of the novel platform, a design of experiment study was performed...
June 15, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28555087/strategic-incorporation-of-fluorine-in-the-drug-discovery-of-new-generation-antitubercular-agents-targeting-bacterial-cell-division-protein-ftsz
#11
Iwao Ojima, Divya Awasthi, Longfei Wei, Krupanandan Haranahalli
This article presents an account of our research on the discovery and development of new-generation fluorine-containing antibacterial agents against drug-resistant tuberculosis, targeting FtsZ. FtsZ is an essential protein for bacterial cell division and a highly promising therapeutic target for antibacterial drug discovery. Through design, synthesis and semi-HTP screening of libraries of novel benzimidazoles, followed by SAR studies, we identified highly potent lead compounds. However, these lead compounds were found to lack sufficient metabolic and plasma stabilities...
April 2017: Journal of Fluorine Chemistry
https://www.readbyqxmd.com/read/28525289/high-throughput-phenotyping-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-and-neurons-using-electric-field-stimulation-and-high-speed-fluorescence-imaging
#12
Neil J Daily, Zhong-Wei Du, Tetsuro Wakatsuki
Electrophysiology of excitable cells, including muscle cells and neurons, has been measured by making direct contact with a single cell using a micropipette electrode. To increase the assay throughput, optical devices such as microscopes and microplate readers have been used to analyze electrophysiology of multiple cells. We have established a high-throughput (HTP) analysis of action potentials (APs) in highly enriched motor neurons and cardiomyocytes (CMs) that are differentiated from human induced pluripotent stem cells (iPSCs)...
May 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28521159/distribution-and-genetic-diversity-of-microbial-populations-in-the-pilot-scale-biofilter-for-simultaneous-removal-of-ammonia-iron-and-manganese-from-real-groundwater
#13
Qingfeng Cheng, Lichao Nengzi, Linlin Bao, Yang Huang, Shengyu Liu, Xiuwen Cheng, Bo Li, Jie Zhang
A pilot-scale biofilter treating real groundwater was developed in this study, which showed that ammonia, iron and manganese were mainly removed at 0.4, 0.4 and 0.8 m of the filter bed, respectively, and the corresponding removal efficiencies were 90.82%, 95.48% and 95.90% in steady phase, respectively. The variation of microbial populations in the biofilter during start-up process was also investigated using high-throughput pyrosequencing (HTP). Results indicated that the main functional microbes for ammonia, iron and manganese removal were Nitrosomonas, Crenothrix and Crenothrix, respectively, which was mainly distributed at 0...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28513694/atomic-scale-observation-of-a-defect-mediated-first-order-phase-transition-in-vo2-a
#14
Chao Jiang, Lu Chen, Shidong Ji, Jun Liu, Zhengfei Zhang, Ping Jin, Yong Wang, Ze Zhang
The study of first-order structural transformations has attracted extensive attention due to their significant scientific and industrial importance. However, it remains challenging to exactly determine the nucleation sites at the very beginning of the transformation. Here, we report the atomic scale real-time observation of a unique defect-mediated reversible phase transition between the low temperature phase (LTP) and the high temperature phase (HTP) of VO2(A). In situ Cs-corrected scanning transmission electron microscopy (STEM) images clearly indicate that both phase transitions (from the HTP to the LTP and from the LTP to the HTP) start at the defect sites in parent phases...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28502117/passive-membrane-penetration-of-the-serotonin-precursor-5-hydroxytryptophan-is-controlled-by-its-zwitterion
#15
Károly Mazák, Béla Noszál
Species-specific partition coefficients in the octanol/water system were determined for the neurotransmitter serotonin (5-HT) and its precursor 5-hydroxytryptophan (5-HTP). The pH-independent partition coefficients (p) of the individual microspecies were determined by combination of experimentally measured distribution constants and a custom-tailored evaluation method, using highly similar auxiliary compounds. Experimental microscopic partition coefficients for triprotic molecules have only been reported before for thyroxine and its derivatives...
May 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28489830/-clinical-and-laboratory-characteristics-of-patients-with-pulmonary-hypertension-and-pulmonary-vascular-complications-hospitalized-at-the-instituto-nacional-de-salud-del-ni%C3%A3-o
#16
Alexis Jose Ormeño Julca, Carlos Melchor Alvarez Murillo, Pedro Miguel Amoretti Alvino, Angel Aladino Florian Florian, Rosa Aurora Castro Johanson, Maria Danisa Celi Perez, Olga Rocío Huamán Prado
The hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPHN) are distinct pulmonary vascular complications of portal hypertension (PHT) and are associated with increased morbidity and mortality. OBJECTIVES: To describe the clinical and laboratory characteristics of patients with pulmonary hypertension and pulmonary vascular complications hospitalized at the Instituto Nacional de Salud del Niño. MATERIALS AND METHODS: We included patients with HTP hospitalized from January 2012 to June 2013 and that during its evolution progressed with SHP or HTPP...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28485580/solution-processed-organic-and-halide-perovskite-transistors-on-hydrophobic-surfaces
#17
Jeremy W Ward, Hannah L Smith, Andrew Zeidell, Peter J Diemer, Stephen R Baker, Hyunsu Lee, Marcia M Payne, John E Anthony, Martin Guthold, Oana D Jurchescu
Solution-processable electronic devices are highly desirable due to their low cost and compatibility with flexible substrates. However, they are often challenging to fabricate due to the hydrophobic nature of the surfaces of the constituent layers. Here, we use a protein solution to modify the surface properties and to improve the wettability of the fluoropolymer dielectric Cytop. The engineered hydrophilic surface is successfully incorporated in bottom-gate solution-deposited organic field-effect transistors (OFETs) and hybrid organic-inorganic trihalide perovskite field-effect transistors (HTP-FETs) fabricated on flexible substrates...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28456683/patchouli-alcohol-ameliorates-dextran-sodium-sulfate-induced-experimental-colitis-and-suppresses-tryptophan-catabolism
#18
Chang Qu, Zhong-Wen Yuan, Xiu-Ting Yu, Yan-Feng Huang, Guang-Hua Yang, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su, Hui-Fang Zeng, Ying Xie, Xiao-Jun Zhang
Despite the increased morbidity of ulcerative colitis (UC) in recent years, available treatments remain unsatisfactory. Pogostemon cablin has been widely applied to treat a variety of gastrointestinal disorders in clinic for centuries, in which patchouli alcohol (PA, C15H26O) has been identified as the major active component. This study attempted to determine the bioactivity of PA on dextran sulfate sodium (DSS)-induced mice colitis and clarify the mechanism of action. Acute colitis was induced in mice by 3% DSS for 7 days...
April 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28447897/specific-hepatic-stellate-cell-penetrating-peptide-targeted-delivery-of-a-kla-peptide-reduces-collagen-accumulation-by-inducing-apoptosis
#19
Zhengrong Guo, Dong Li, Huanyan Peng, Jiwen Kang, Xiaoyu Jiang, Xiaoli Xie, Dianxing Sun, Huiqing Jiang
Liver fibrosis is an aberrant wound-healing process to chronic hepatic inflammation and is characterized by excessive accumulation of extracellular matrix (ECM) that is produced by activated hepatic stellate cells (HSCs). Thus, activated HSCs play a key role in the pathogenesis of liver fibrosis and are a potential target for the treatment of liver fibrosis. Herein, we report that a specific HSC-penetrating peptide reduced collagen accumulation by inducing the apoptosis of HSC-T6 cells. We first screened HSC-specific transduction peptides and identified a novel HSC-targeted cell-penetrating peptide (HTP) that specifically interacted with HSC-T6 cells...
September 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28434742/endocrine-and-metabolic-changes-in-transition-dairy-cows-are-affected-by-prepartum-infusions-of-a-serotonin-precursor
#20
Lorenzo E Hernández-Castellano, Laura L Hernandez, Helga Sauerwein, Rupert M Bruckmaier
Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period...
April 20, 2017: Journal of Dairy Science
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