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https://www.readbyqxmd.com/read/29763816/design-of-a-phase-3-trial-of-intracoronary-administration-of-human-adenovirus-5-encoding-human-adenylyl-cyclase-type-6-rt-100-gene-transfer-in-patients-with-heart-failure-with-reduced-left-ventricular-ejection-fraction-the-flourish-clinical-trial
#1
William F Penny, Timothy D Henry, Matthew W Watkins, Amit N Patel, H Kirk Hammond
The prognosis of patients with HFrEF remains poor despite the use of current medical and device therapies. Preclinical studies of HFrEF using IC delivery of RT-100, a replication deficient, E1/E3-deleted human adenovirus 5 encoding human AC6 was associated with favorable effects on LV function and remodeling. A recent multicenter, double-blind, placebo-controlled, phase 2 study demonstrated the safety of IC delivery of RT-100 in HFrEF patients and potential efficacy at the higher doses. This phase 2 dose finding study, which included doses not expected to be effective, identified a potential reduction in congestive heart failure admissions in the AC6-treated group one year after randomization...
April 6, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29762797/contrasting-incoming-medical-students-attitudes-dual-degree-vs-traditional-tracks
#2
Kristina A Monteiro, Karl Dietrich, Jeffrey Borkan, Luba Dumenco, Allan R Tunkel, Richard Dollase, Paul George
BACKGROUND AND OBJECTIVES: The Warren Alpert Medical School of Brown University (AMS) recently implemented a novel dual degree MD-ScM program in primary care and population medicine (PC-PM) that enrolls up to 24 of its nearly 144 yearly matriculants. The overarching goal of this track is to train medical students to become physician leaders who focus on issues in population medicine within primary care. METHODS: We conducted a baseline assessment of the students enrolled in this parallel track in comparison to our traditional students to identify characteristics of and group differences between students in the PC-PM program and traditional students...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29760830/patient-and-provider-perspectives-on-adherence-to-and-care-coordination-of-lynch-syndrome-surveillance-recommendations-findings-from-qualitative-interviews
#3
Jennifer L Schneider, Katrina A B Goddard, Kristin R Muessig, James V Davis, Alan F Rope, Jessica E Hunter, Susan K Peterson, Louise S Acheson, Sapna Syngal, Georgia L Wiesner, Jacob A Reiss
Background: Patients with a genetic variant associated with Lynch syndrome (LS) are recommended to undergo frequent and repeated cancer surveillance activities to minimize cancer-related morbidity and mortality. Little is known about how patients and primary care providers (PCPs) track and manage these recommendations. We conducted a small exploratory study of patient and PCP experiences with recommended LS surveillance activities and communication with family members in an integrated health care system...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29753915/the-eyes-reveal-uncertainty-about-object-distinctions-in-semantic-variant-primary-progressive-aphasia
#4
Andreia V Faria, David Race, Kevin Kim, Argye E Hillis
At least three distinct variants of primary progressive aphasia (PPA) have been described, but they are difficult to distinguish early in the course, when individuals experience primarily anomia. People with svPPA are often the hardest to care for, because they have impaired comprehension of words and objects and often have negative changes in comportment. We sought to identify an early marker of semantic variant primary progressive aphasia (svPPA) and to enhance the understanding of the semantic deficit in svPPA...
April 3, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29751746/validating-the-use-of-veterans-affairs-tobacco-health-factors-for-assessing-change-in-smoking-status-accuracy-availability-and-approach
#5
Anne C Melzer, Erika A Pinsker, Barbara Clothier, Siamak Noorbaloochi, Diana J Burgess, Elisheva R Danan, Steven S Fu
BACKGROUND: Accurate smoking status is key for research purposes, but can be costly and difficult to measure. Within the Veteran's Health Administration (VA), smoking status is recorded as part of routine care as "health factors" (HF)-fields that researchers can query through the electronic health record (EHR). Many researchers are interested in using these fields to track changes in smoking status over time, however the validity of this measure for assessing change is unknown...
May 11, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29743224/implementation-of-health-insurance-support-tools-in-community-health-centers
#6
Nathalie Huguet, Brigit Hatch, Aleksandra Sumic, Carrie Tillotson, Elizabeth Hicks, Joan Nelson, Jennifer E DeVoe
BACKGROUND: Health information technology (HIT) provides new opportunities for primary care clinics to support patients with health insurance enrollment and maintenance. We present strategies, early findings, and clinic reflections on the development and implementation of HIT tools designed to streamline and improve health insurance tracking at community health centers. METHODS: We are conducting a hybrid implementation-effectiveness trial to assess novel health insurance enrollment and support tools in primary care clinics...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29743217/strategies-for-addressing-the-challenges-of-patient-centered-medical-home-implementation-lessons-from-oregon
#7
Sherril Gelmon, Nicole Bouranis, Billie Sandberg, Shauna Petchel
BACKGROUND: Patient-centered medical homes (PCMHs) are at the forefront of the transformation of primary care as part of health systems reform. Despite robust literature describing implementation challenges, few studies describe strategies being used to overcome these challenges. This article addresses this gap through observations of exemplary PCMHs in Oregon, where the Oregon Health Authority supports and recognizes Patient-Centered Primary Care Homes (PCPCH). METHODS: Twenty exemplary PCPCHs were selected using program scores, with considerations for diversity in clinic characteristics...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29730244/family-caregiver-marginalization-is-associated-with-decreased-primary-and-subspecialty-asthma-care-in-head-start-children
#8
S Christy Sadreameli, Kristin A Riekert, Elizabeth C Matsui, Cynthia S Rand, Michelle N Eakin
BACKGROUND: Urban minority children are at risk for poor asthma outcomes and may not receive appropriate primary or subspecialty care. OBJECTIVE: We hypothesized that preschool children with asthma whose caregivers reported more barriers to care would be less likely to have seen their primary care provider (PCP) or an asthma subspecialist and more likely to have had a recent emergency department (ED) visit for asthma. METHODS: The Barriers to Care Questionnaire (BCQ) measures expectations, knowledge, marginalization, pragmatics, and skills...
May 3, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29728349/-the-doctor-needs-to-know-acceptability-of-smartphone-location-tracking-for-care-coordination
#9
David T Liss, Eloisa Serrano, Julie Wakeman, Christine Nowicki, David R Buchanan, Ana Cesan, Tiffany Brown
BACKGROUND: Care coordination can be highly challenging to carry out. When care is fragmented across health systems and providers, there is an increased likelihood of hospital readmissions and wasteful health care spending. During and after care transitions, smartphones have the potential to bolster information transfer and care coordination. However, little research has examined patients' perceptions of using smartphones to coordinate care. OBJECTIVE: This study's primary objective was to explore patient acceptability of a smartphone app that could facilitate care coordination in a safety net setting...
May 4, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29721362/career-paths-of-pathology-informatics-fellowship-alumni
#10
Joseph W Rudolf, Christopher A Garcia, Matthew G Hanna, Christopher L Williams, Ulysses G Balis, Liron Pantanowitz, J Mark Tuthill, John R Gilbertson
Background: The alumni of today's Pathology Informatics and Clinical Informatics fellowships fill diverse roles in academia, large health systems, and industry. The evolving training tracks and curriculum of Pathology Informatics fellowships have been well documented. However, less attention has been given to the posttraining experiences of graduates from informatics training programs. Here, we examine the career paths of subspecialty fellowship-trained pathology informaticians. Methods: Alumni from four Pathology Informatics fellowship training programs were contacted for their voluntary participation in the study...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29720359/diffusion-of-the-digital-health-self-tracking-movement-in-canada-results-of-a-national-survey
#11
Guy Paré, Chad Leaver, Claire Bourget
BACKGROUND: With the ever-increasing availability of mobile apps, consumer wearables, and smart medical devices, more and more individuals are self-tracking and managing their personal health data. OBJECTIVE: The aim of this study was to investigate the diffusion of the digital self-tracking movement in Canada. It provides a comprehensive, yet detailed account of this phenomenon. It examines the profile of digital self-trackers, traditional self-trackers, and nontrackers, further investigating the primary motivations for self-tracking and reasons for nontracking; barriers to adoption of connected care technologies; users' appreciation of their self-tracking devices, including what they perceive to be the main benefits; factors that influence people's intention to continue using connected care technologies in the future; and the reasons for usage discontinuance...
May 2, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29713588/three-parallel-information-systems-for-malaria-elimination-in-swaziland-2010-2015-are-the-numbers-the-same
#12
Z Zulu, S Kunene, N Mkhonta, P Owiti, W Sikhondze, M Mhlanga, Z Simelane, E Geoffroy, R Zachariah
Background: To be able to eliminate malaria, accurate, timely reporting and tracking of all confirmed malaria cases is crucial. Swaziland, a country in the process of eliminating malaria, has three parallel health information systems. Design: This was a cross-sectional study using country-wide programme data from 2010 to 2015. Methods: The Malaria Surveillance Database System (MSDS) is a comprehensive malaria database, the Immediate Disease Notification System (IDNS) is meant to provide early warning and trigger case investigations to prevent onward malaria transmission and potential epidemics, and the Health Management Information Systems (HMIS) reports on all morbidity at health facility level...
April 25, 2018: Public Health Action
https://www.readbyqxmd.com/read/29693481/express-streamlining-cardiopulmonary-exercise-testing-for-use-as-a-screening-and-tracking-tool-in-primary-care
#13
Chul-Ho Kim, Erik H Van Iterson, James E Hansen, Dean J MacCarter, Bruce D Johnson
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29664873/effects-of-a-picu-status-asthmaticus-de-escalation-pathway-on-length-of-stay-and-albuterol-use
#14
Steven Brennan, Lia Lowrie, Jamie Wooldridge
OBJECTIVES: Evaluate the effects of an asthma de-escalation clinical pathway on selected outcomes for patients admitted to a PICU with status asthmaticus. DESIGN: Time series quality improvement trial. SETTING: PICU in a tertiary care children's hospital. PATIENTS: Children age 2-18 years old with a known diagnosis of asthma presenting with status asthmaticus. INTERVENTION: One-hundred five admissions to a PICU for status asthmaticus were treated according to a new de-escalation pathway between August 15, 2015, and August 30, 2016...
April 16, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29655517/integrating-pregnancy-prevention-into-an-hiv-counseling-and-testing-program-in-pediatric-primary-care
#15
Noah J Wheeler, Krishna K Upadhya, Marie-Sophie Tawe, Kathy Tomaszewski, Renata Arrington-Sanders, Arik V Marcell
PURPOSE: Certified health educator (CHE)-based HIV counseling and testing typically focus on HIV and sexually transmitted infection (STI) prevention only. A quality improvement initiative examined integrating assessment of reproductive life plans, counseling about pregnancy prevention, and contraception referral into a CHE-based HIV testing program. METHODS: Between February 2014 and January 2017, in one urban pediatric primary care clinic serving patients aged 0-25, CHEs assessed sexual history, HIV risk, short-term (i...
April 11, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29643170/treatment-options-in-idiopathic-subglottic-stenosis-protocol-for-a-prospective-international-multicentre-pragmatic-trial
#16
Alexander Gelbard, Yu Shyr, Lynne Berry, Alexander T Hillel, Dale C Ekbom, Eric S Edell, Jan L Kasperbauer, David G Lott, Donald T Donovan, C Gaelyn Garrett, Guri Sandhu, James J Daniero, James L Netterville, Josh S Schindler, Marshall E Smith, Paul C Bryson, Robert R Lorenz, David O Francis
INTRODUCTION: Idiopathic subglottic stenosis (iSGS) is an unexplained progressive obstruction of the upper airway that occurs almost exclusively in adult, Caucasian women. The disease is characterised by mucosal inflammation and localised fibrosis resulting in life-threatening blockage of the upper airway. Because of high recurrence rates, patients with iSGS will frequently require multiple procedures following their initial diagnosis. Both the disease and its therapies profoundly affect patients' ability to breathe, communicate and swallow...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29643053/a-novel-mobile-app-and-population-management-system-to-manage-rheumatoid-arthritis-flares-protocol-for-a-randomized-controlled-trial
#17
Penny Wang, Dee Luo, Fengxin Lu, Josephine S Elias, Adam B Landman, Kaleb D Michaud, Yvonne C Lee
BACKGROUND: Rheumatoid arthritis flares have a profound effect on patients, causing pain and disability. However, flares often occur between regularly scheduled health care provider visits and are, therefore, difficult to monitor and manage. We sought to develop a mobile phone app combined with a population management system to help track RA flares between visits. OBJECTIVE: The objective of this study is to implement the mobile app plus the population management system to monitor rheumatoid arthritis disease activity between scheduled health care provider visits over a period of 6 months...
April 11, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29629923/organizational-processes-and-patient-experiences-in-the-patient-centered-medical-home
#18
Jaya Aysola, Marilyn M Schapira, Hairong Huo, Rachel M Werner
BACKGROUND: There is increasing emphasis on the use of patient-reported experience data to assess practice performance, particularly in the setting of patient-centered medical homes. Yet we lack understanding of what organizational processes relate to patient experiences. OBJECTIVE: Examine associations between organizational processes practices adopt to become PCMH and patient experiences with care. RESEARCH DESIGN: We analyzed visit data from patients (n=8356) at adult primary care practices (n=22) in a large health system...
April 6, 2018: Medical Care
https://www.readbyqxmd.com/read/29625232/shared-care-using-an-electronic-consult-form-to-facilitate-pcp-specialty-care-coordination
#19
Corinna J Rea, Larissa M Wenren, Katherine D Tran, Eric Zwemer, Daniel Mallon, Miya Bernson-Leung, Ronald C Samuels, Sara L Toomey
OBJECTIVE: The quality of children's health is compromised by poor care coordination between primary care providers (PCPs) and specialists. Our objective was to determine how an electronic consultation and referral system impacts referral patterns and PCP-specialist communication. METHODS: The primary care clinic at Boston Children's Hospital piloted an electronic referral and consultation system with the Neurology and Gastroenterology departments from 4/1/14-10/31/16...
April 3, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29622527/epic-allies-a-gamified-mobile-phone-app-to-improve-engagement-in-care-antiretroviral-uptake-and-adherence-among-young-men-who-have-sex-with-men-and-young-transgender-women-who-have-sex-with-men-protocol-for-a-randomized-controlled-trial
#20
Sara LeGrand, Kathryn E Muessig, Alyssa Platt, Karina Soni, Joseph R Egger, Nkechinyere Nwoko, Tobias McNulty, Lisa B Hightow-Weidman
BACKGROUND: In the United States, young men who have sex with men (YMSM) and transgender women who have sex with men (YTWSM) bear a disproportionate burden of prevalent and incident HIV infections. Once diagnosed, many YMSM and YTWSM struggle to engage in HIV care, adhere to antiretroviral therapy (ART), and achieve viral suppression. Computer-based interventions, including those focused on behavior change, are recognized as effective tools for engaging youth. OBJECTIVE: The purpose of the study described in this protocol is to evaluate the efficacy of Epic Allies, a theory-based mobile phone app that utilizes game mechanics and social networking features to improve engagement in HIV care, ART uptake, ART adherence, and viral suppression among HIV-positive YMSM and YTWSM...
April 5, 2018: JMIR Research Protocols
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