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trichosporon asahii

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https://www.readbyqxmd.com/read/28510690/trichosporonosis-in-pediatric-patients-with-a-hematologic-disorder
#1
Catherine E Foster, Morven S Edwards, Julienne Brackett, Deborah A Schady, C Mary Healy, Carol J Baker
Background.: Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods.: We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute lymphoblastic leukemia at Texas Children's Hospital in Houston, Texas. We also conducted a literature review and identified 16 additional reports of pediatric patients with invasive T asahii infection and an underlying malignant or nonmalignant hematologic disorder...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28506251/diversity-in-vitro-virulence-traits-and-antifungal-susceptibility-pattern-of-gastrointestinal-yeast-flora-of-healthy-poultry-gallus-gallus-domesticus
#2
Supram Hosuru Subramanya, Nawal Kishor Sharan, Bharat Prasad Baral, Deependra Hamal, Niranjan Nayak, Peralam Yegneswaran Prakash, Brijesh Sathian, Indira Bairy, Shishir Gokhale
BACKGROUND: Poultry farming and consumption of poultry (Gallus gallus domesticus) meat and eggs are common gastronomical practices worldwide. Till now, a detailed understanding about the gut colonisation of Gallus gallus domesticus by yeasts and their virulence properties and drug resistance patterns in available literature remain sparse. This study was undertaken to explore this prevalent issue. RESULTS: A total of 103 specimens of fresh droppings of broiler chickens (commercial G domesticus) and domesticated chickens (domesticated G domesticus) were collected from the breeding sites...
May 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28458355/growth-inhibition-of-an-opportunistic-yeast-pathogen-trichosporon-asahii-by-staphylococcus-epidermidis
#3
Reiko Ikeda, Yuki Ogasawara, Kazuhiko Takatori, Tomoe Ichikawa, Miki Nakajima, Kazuko Harigaya, Miho Watanabe, Erika Okudaira, Hanari Yoshikawa, Kazuki Yanagisawa
In the co-culture of Staphylococcus epidermidis and Trichosporon asahii, a fungal pathogen, it was observed that live S. epidermidis inhibited the growth of T. asahii. Soluble active anti-T. asahii substances were speculated to be produced by S. epidermidis in culture medium. Using (1)H- and (13)C-NMR spectra and electron ionization-high resolution mass spectrometry (HR-negative-FAB-MS), we separated the active molecule and identified it as lactic acid. Commercially available L-lactic acid and D-lactic acid inhibited the growth of T...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28439501/the-cell-biology-of-the-trichosporon-host-interaction
#4
REVIEW
Cláudio Duarte-Oliveira, Fernando Rodrigues, Samuel M Gonçalves, Gustavo H Goldman, Agostinho Carvalho, Cristina Cunha
Fungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among immunocompromised hosts, such as hematological patients and solid organ transplant recipients. The initiation of commensal or pathogenic programs by Trichosporon spp. involves the adaptation to the host microenvironment and its immune system...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28340200/cytokines-profile-in-immunocompetent-mice-during-trichosporon-asahii-infection
#5
Alexandra M Montoya, Gloria M González, Azalia M Martinez-Castilla, Sonia A Aguilar, Moises A Franco-Molina, Erika Coronado-Cerda, Adrián G Rosas-Taraco
Trichosporon asahii is an opportunistic yeastlike fungus commonly associated with systemic infections in immunocompromised patients. Neutropenia is recognized as the main risk factor in infections by T. asahii; however, little is known about the cytokine response during trichosporonosis. Here, we evaluated systemic and local cytokine production and histological damage in immunocompetent mice during systemic infection with T. asahii. We found a significant increased presence of G-CSF, TNF-α, IFN-γ, and IL-6 in sera samples...
March 15, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28339535/fungemia-due-to-rare-opportunistic-yeasts-data-from-a-population-based-surveillance-in-spain
#6
Mario Fernández-Ruiz, Jesús Guinea, Mireia Puig-Asensio, Óscar Zaragoza, Benito Almirante, Manuel Cuenca-Estrella, José María Aguado
Fungemia due to rare yeasts constitutes an emerging but poorly investigated condition. Data on risk factors, clinical features, therapy, and outcome of episodes of fungemia due to rare (non-Candida, non-Cryptococcus) yeasts were analyzed in a population-based surveillance program conducted in 29 Spanish hospitals between May 2010 and April 2011. Species identification (DNA sequencing) and antifungal susceptibility testing (EUCAST and CLSI methods) were centrally performed. Fourteen out of 767 episodes of fungemia (1...
August 5, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28303817/screening-of-invasive-fungal-infections-by-a-real-time-panfungal-pan-acf-polymerase-chain-reaction-assay-in-patients-with-haematological-malignancy
#7
COMPARATIVE STUDY
Malini Rajinder Capoor, Shikha Puri, Hitesh Raheja, Ritin Mohindra, Dinesh Kumar Gupta, Pradeep Kumar Verma, Ranadeep Chowdhary
BACKGROUND: Invasive fungal infection (IFI) is a fatal infection in haematology patients. There is an urgent need for reliable screening methods facilitating timely diagnosis and treatment. A real-time panfungal polymerase chain reaction (PCR) assay based on TaqMan technology targeting 18S ribosomal RNA gene was used to screen whole blood specimen obtained from series of Haematology malignancy patients for IFIs. MATERIALS AND METHODS: The panfungal (Pan-ACF) assay was employed to investigate specimen from 133 patients in duplicate with suspected IFI...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28250360/a-new-amino-acid-substitution-at-g150s-in-lanosterol-14-%C3%AE-demethylase-erg11-protein-in-multi-azole-resistant-trichosporon-asahii
#8
Hisako Kushima, Issei Tokimatsu, Hiroshi Ishii, Rie Kawano, Kentaro Watanabe, Jun-Ichi Kadota
The mechanisms of azole resistance in Trichosporon asahii have not yet been fully clarified. We previously showed that T. asahii has the ERG11 gene, coding lanosterol 14-α-demethylase (Erg11 protein; Erg11p), which is the primary target of azoles. A single amino acid substitution at G453R in Erg11p was found to induce changes in the affinity of this enzyme for azoles, especially fluconazole, in vitro. In the present study, we investigated the DNA sequences of the ERG11 gene using six different strains of clinically isolated T...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28144822/in-vitro-activity-of-berberine-alone-and-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-trichosporon-asahii
#9
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients, with high mortality rates up to 80% despite treated with antifungal drugs. The biofilms-forming ability of T. asahii on indwelling medical devices may account for the resistance to antifungal drugs. Berberine (BBR) has been demonstrated to have antifungal activity and synergistic effects in combination with antifungal drugs against pathogenic fungi. In the present study, the in vitro activities of BBR alone or combined with fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against planktonic forms and biofilms of 21 clinical T...
January 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28141498/first-genotype-identification-of-trichosporon-asahii-in-sfax-tunisia
#10
Hayet Sellami, Houaida Trabelsi, Sourour Neji, Imen Amouri, Fatma Cheikhrouhou, Fattouma Makni, Ali Ayadi
PURPOSE: The objectives of our study were species identification and genotyping of Trichosporon isolates collected at the Parasitology and Mycology Laboratory in Sfax, Tunisia. METHODOLOGY: Molecular identification was carried out by analysing the IGS1 regions of the rDNA of 30 Trichosporon isolates. RESULTS: Trichosporon asahii was the most frequent species detected. Furthermore, four genotypes were identified in Tunisia: 1 (46.4 %), 4 (35...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28031829/summer-type-hypersensitivity-pneumonitis-in-a-patient-with-rheumatoid-arthritis-on-methotrexate-and-tacrolimus
#11
Hirotsugu Ohkubo, Minami Okayama, Kensuke Fukumitsu, Akio Niimi
A 59-year-old woman receiving methotrexate and tacrolimus for rheumatoid arthritis (RA) was referred to our hospital following bilateral ground-glass opacity observed in her chest X-ray and elevated serum KL-6. After methotrexate and tacrolimus cessation, shortness of breath developed and ground-glass opacity observed in the chest computed tomography rapidly worsened. Bronchoalveolar lavage showed increased lymphocytes, and trans-bronchial lung biopsy confirmed lymphocytic alveolitis. In addition, the patient had serum antibodies against Trichosporon asahii, a fungal pathogen...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/27930704/in-vitro-antifungal-activity-of-sertraline-and-synergistic-effects-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-clinical-trichosporon-asahii-isolates
#12
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is the major pathogen of invasive trichosporonosis which occurred mostly in immunocompromised patients. The biofilms formation ability of T. asahii may account for resistance to antifungal drugs and results a high mortality rate. Sertraline, a commonly prescribed antidepressant, has been demonstrated to show in vitro and in vivo antifungal activities against many kinds of pathogenic fungi, especially Cryptococcus species. In the present study, the in vitro activities of sertraline alone or combined with fluconazole, voriconazole, itraconazole, caspofungin and amphotericin B against planktonic forms and biofilms of 21 clinical T...
2016: PloS One
https://www.readbyqxmd.com/read/27886119/synthesis-and-antifungal-screening-of-2-1-5-alkyl-arylalkylpyrazin-2-yl-ethylidene-hydrazono-1-3-thiazolidin-4-ones
#13
Veronika Opletalova, Jan Dolezel, Jiri Kunes, Vladimir Buchta, Marcela Vejsova, Marta Kucerova-Chlupacova
Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27862261/cell-surface-hydrophobicity-and-colony-morphology-of-trichosporon-asahii-clinical-isolates
#14
Tomoe Ichikawa, Chihiro Hirata, Mizuki Takei, Naoyuki Tagami, Hiromi Murasawa, Reiko Ikeda
Trichosporon asahii is a pathogenic basidiomycetous yeast. Individual strains of T. asahii have different colony morphologies. However, it is not clear whether cell surface phenotypes differ among the colony morphologies. Here we characterized the cell surface hydrophobicity and analysed the carbohydrate contents of the cell surface polysaccharides in T. asahii clinical isolates with various colony morphologies. Among the three distinctive colony morphologies obtained from one clinical isolate, the white-type morphology exhibited higher hydrophobicity...
November 8, 2016: Yeast
https://www.readbyqxmd.com/read/27816903/molecular-and-antifungal-susceptibility-study-on-trichosporonemia-and-emergence-of-trichosporon-mycotoxinivorans-as-a-bloodstream-pathogen
#15
Yubhisha Dabas, Immaculata Xess, Pratibha Kale
A total of 21 Trichosporon spp. isolates from blood over a period of 5 years (January 2009 to December 2013) were included in the study. The most common underlying diseases found were pancreatitis (33.3%) and cancer (33.3%). Trichosporon asahii (80.9%) was the commonest species followed by Trichosporon mycotoxinivorans (14.2%) and Trichosporon faecale (4.7%). On IGS1 region sequencing the most predominant T. asahii type in our region was genotype 1 (16/17 isolates; 94.1%) and one isolate belonged to genotype 4...
November 5, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27799926/invasive-trichosporon-infection-a-systematic-review-on-a-re-emerging-fungal-pathogen
#16
REVIEW
João N de Almeida Júnior, Christophe Hennequin
Objectives: This review aimed to better depict the clinical features and address the issue of therapeutic management of Trichosporon deep-seated infections. Methods: We comprehensively reviewed the cases of invasive Trichosporon infection reported in the literature from 1994 (date of taxonomic modification) to 2015. Data from antifungal susceptibility testing (AST) studies were also analyzed. Results: Two hundred and three cases were retained and split into four groups: homeopathy (n = 79), other immunodeficiency conditions (n = 41), miscellaneous (n = 58) and newborns (n = 25)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27794247/diversity-of-spoilage-fungi-associated-with-various-french-dairy-products
#17
Lucille Garnier, Florence Valence, Audrey Pawtowski, Lizaveta Auhustsinava-Galerne, Nicolas Frotté, Riccardo Baroncelli, Franck Deniel, Emmanuel Coton, Jérôme Mounier
Yeasts and molds are responsible for dairy product spoilage, resulting in significant food waste and economic losses. Yet, few studies have investigated the diversity of spoilage fungi encountered in dairy products. In the present study, 175 isolates corresponding to 105 from various spoiled dairy products and 70 originating from dairy production environments, were identified using sequencing of the ITS region, the partial β-tubulin, calmodulin and/or EFα genes, and the D1-D2 domain of the 26S rRNA gene for filamentous fungi and yeasts, respectively...
January 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27784941/study-on-antioxidant-enzymatic-activities-of-trichosporon-asahii
#18
Yangmei Zhang, Haitao Li, Rongya Yang, Congmin Wang
Superoxide dismutase (SOD) and catalase are considered the most important antioxidant enzymes which protect fungus from the oxidant damage of reactive oxygen species. In this study, we collected 44 strains of Trichosporon asahii (T. asahii) from different sources and investigated their SOD and catalase activities. The results showed that the SOD and catalase activities of Clinical group were significantly higher than those of Environment group (p < 0.01). The SOD and catalase activities of T. asahii in Internal passage group went up gradually after passage in mice, and were significantly higher in 5th generation of Internal passage group (p < 0...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27697432/antifungal-activities-of-tacrolimus-in-combination-with-antifungal-agents-against-fluconazole-susceptible-and-fluconazole-resistant-trichosporon-asahii-isolates
#19
Thaís Felli Kubiça, Laura Bedin Denardi, Maria Isabel Azevedo, Vanessa Oliveira, Luiz Carlos Severo, Janio Morais Santurio, Sydney Hartz Alves
The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of both fluconazole-susceptible and fluconazole-resistant Trichosporon asahii. For these analyses, we used the broth microdilution method based on the M27-A3 technique and checkerboard microdilution method. Tacrolimus showed no activity against T...
November 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27495321/fungemia-due-to-rare-opportunistic-yeasts-data-from-a-population-based-surveillance-in-spain
#20
Mario Fernández-Ruiz, Jesús Guinea, Mireia Puig-Asensio, Óscar Zaragoza, Benito Almirante, Manuel Cuenca-Estrella, José María Aguado
Fungemia due to rare yeasts constitutes an emerging but poorly investigated condition. Data on risk factors, clinical features, therapy, and outcome of episodes of fungemia due to rare (non-Candida, non-Cryptococcus) yeasts were analyzed in a population-based surveillance program conducted in 29 Spanish hospitals between May 2010 and April 2011. Species identification (DNA sequencing) and antifungal susceptibility testing (EUCAST and CLSI methods) were centrally performed. Fourteen out of 767 episodes of fungemia (1...
February 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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