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https://www.readbyqxmd.com/read/29028570/bovine-ovarian-follicular-growth-and-development-correlate-with-lysophosphatidic-acid-expression
#1
Emilia Sinderewicz, Katarzyna Grycmacher, Dorota Boruszewska, Ilona Kowalczyk-Zięba, Joanna Staszkiewicz, Tomasz Ślężak, Izabela Woclawek-Potocka
The basis of successful reproduction is proper ovarian follicular growth and development. In addition to prostaglandins and vascular endothelial growth factor, a number of novel factors are suggested as important regulators of follicular growth and development: PGES, TFG, CD36, RABGAP1, DBI and BTC. This study focuses on examining the expression of these factors in granulosa and thecal cells that originate from different ovarian follicle types and their link with the expression of lysophosphatidic acid (LPA), known local regulator of reproductive functions in the cow...
September 25, 2017: Theriogenology
https://www.readbyqxmd.com/read/29027050/characterization-and-origin-of-organic-and-inorganic-pollution-in-urban-soils-in-pisa-tuscany-italy
#2
Roberto Cardelli, Giacomo Vanni, Fausto Marchini, Alessandro Saviozzi
We assessed the quality of 31 urban soils in Pisa by analyzing total petroleum hydrocarbons (TPHs), Cd, Cr, Cu, Hg, Mn, Ni, Pb, Zn, and the platinum group elements (PGEs). The risk was evaluated by the geological accumulation index (I geo) and the enrichment factor (EF). Results were compared with those obtained from a non-urban site and with the quantitative limits fixed by Italian legislation. In nearly all the monitored sites, the legal limit for TPH of 60 mg/kg in residential areas was exceeded, indicating widespread and intense pollution throughout the entire city area...
October 12, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28992492/tracing-platinum-accumulation-kinetics-in-oyster-crassostrea-gigas-a-sentinel-species-in-coastal-marine-environments
#3
Melina Abdou, Lionel Dutruch, Jörg Schäfer, Beñat Zaldibar, Rebeca Medrano, Urtzi Izagirre, Teba Gil-Díaz, Cécile Bossy, Charlotte Catrouillet, Ruoyu Hu, Alexandra Coynel, Antoine Lerat, Antonio Cobelo-García, Gérard Blanc, Manu Soto
Platinum Group Elements (PGEs) are extremely scarce in the Earth's Crust and of strong interest for high-end technologies due to their specific properties. They belong to the Technology Critical Elements (TCEs) for which use is forecast to increase, implying growing emissions into the environment in the following years. In particular, with the intensive use of platinum (Pt) in car catalytic converters, the anthropogenic geochemical cycle of this element has surpassed the natural cycle. Yet, environmental Pt levels are still in the sub picomolar range, making its analytical detection a challenge...
October 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28979673/cox-2-mediates-pm2-5-induced-apoptosis-and-inflammation-in-vascular-endothelial-cells
#4
Jie Yin, Weiwei Xia, Yuanyuan Li, Chuchu Guo, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhang
Emerging evidence demonstrated that particulate matter 2.5 (PM2.5) exposure served as an important risk factor of cardiovascular diseases. Some studies also reported that COX-2/mPGES-1/PGE2 cascade played a pathogenic role in vascular injury. However, the relationship between the PM2.5 exposure and the activation of COX-2/mPGES-1/PGE2 cascade in endothelial cells is still unknown. In the present study, mouse aorta endothelial cells were exposed to PM2.5. Strikingly, following the PM2.5 treatment, we observed dose- and time-dependent upregulation of COX-2 at both protein and mRNA levels as determined by Western blotting and qRT-PCR, respectively...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28854439/mpges-1-derived-pge2-contributes-to-indoxyl-sulfate-induced-mesangial-cell-proliferation
#5
Shuzhen Li, Zhenzhen Sun, Guixia Ding, Wei Gong, Jing Yu, Weiwei Xia, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia
BACKGROUND/AIMS: We previously reported that indoxyl sulfate (IS) could cause mesangial cell (MC) proliferation via a cyclooxygenase (COX)-2-dependent mechanism. However, the specific prostaglandin contributing to COX-2 effect on IS-induced MC proliferation remained unknown. Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation. METHODS: IS was administered to the MCs with or without mPGES-1 siRNA pretreatment to induce the MC proliferation which was determined by cell cycle analysis, DNA synthesis, and the expressions of cyclins...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28845442/etherification-of-glycerol-with-propylene-or-1-butene-for-fuel-additives
#6
Chakrapong Saengarun, Amorn Petsom, Duangamol Nuntasri Tungasmita
The etherification of glycerol with propylene over acidic heterogeneous catalysts, Amberlyst-15, S100, and S200 resins, produced mono-propyl glycerol ethers (MPGEs), 1,3-di- and 1,2-di-propyl glycerol ethers (DPGEs), and tri-propyl glycerol ether (TPGE). The propylation of glycerol over Amberlyst-15 yielded only TPGE. The glycerol etherification with 1-butene over Amberlyst-15 and S200 resins produced 1-mono-, 2-mono-, 1,2-di-, and 1,3-di-butyl glycerol ethers (1-MBGE, 2-MBGE, 1,2-DBGE, and 1,3-DBGE). The use of Amberlyst-15 resulted in the propylation and butylation of glycerol with higher yields than those obtained from the S100 and S200 resins...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28820025/interaction-between-progesterone-and-interleukin-1%C3%AE-in-modulating-progesterone-receptor-expression-and-the-inflammatory-phenotype-in-human-cervical-fibroblasts
#7
Stephanie Pierce, Amy E Roberson, Kimberly Hyatt, Krista Singleton, David Deschamps, Dean A Myers
Progesterone helps maintain cervical structure during pregnancy via the progesterone receptor (PR). Two PR isoforms exist, PR-A and PR-B, which have overlapping as well as isoform-specific target genes. During late gestation, leukocytes infiltrate the cervical stroma accompanied by increased cervical cytokine levels, resembling an inflammatory process. We examined interleukin (IL)-1β regulation of the expression of PR-A, PR-B, and genes governing prostaglandin synthesis in human cervical fibroblasts (HCFs)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28714130/nocturnal-seizures-are-associated-with-more-severe-hypoxemia-and-increased-risk-of-postictal-generalized-eeg-suppression
#8
Véronique Latreille, Myriam Abdennadher, Barbara A Dworetzky, Judith Ramel, David White, Eliot Katz, Marcin Zarowski, Sanjeev Kothare, Milena Pavlova
Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal oxygen saturation. Respiratory measures were examined in 48 recorded seizures (sleep, n = 23, wake, n = 25) from 20 adult patients with epilepsy. Seizures from sleep were associated with lower saturation, as compared to seizures from wakefulness, both during ictal (sleep median = 90...
September 2017: Epilepsia
https://www.readbyqxmd.com/read/28668370/development-of-a-conductivity-based-photothermal-absorbance-detection-microchip-using-polyelectrolytic-gel-electrodes
#9
Honggu Chun, Patty J Dennis, Erin R Ferguson Welch, Jean Pierre Alarie, James W Jorgenson, J Michael Ramsey
The development and application of polyelectrolytic gel electrodes (PGEs) for a microfluidic photothermal absorbance detection system is described. The PGEs are used to measure changes in conductivity based on heat generation by analytes absorbing light and changing the solution viscosity. The PGEs are suitable for direct contact conductivity measurements since they do not degrade with exposure to high electric fields. Both a 2-electrode system with DC voltages and a 3-electrode system with AC voltages were investigated...
June 22, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28600313/novel-microbial-assemblages-dominate-weathered-sulfide-bearing-rock-from-copper-nickel-deposits-in-the-duluth-complex-minnesota-usa
#10
Daniel S Jones, Kim A Lapakko, Zachary J Wenz, Michael C Olson, Elizabeth W Roepke, Michael J Sadowsky, Paige J Novak, Jake V Bailey
The Duluth Complex in northeastern Minnesota hosts economically significant deposits of copper, nickel, and platinum group elements (PGEs). The primary sulfide mineralogy of these deposits includes the minerals pyrrhotite, chalcopyrite, pentlandite, and cubanite, and weathering experiments show that most sulfide-bearing rock from the Duluth Complex generates moderately acidic leachate (pH 4 to 6). Microorganisms are important catalysts for metal sulfide oxidation and could influence the quality of water from mines in the Duluth Complex...
August 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28576433/postictal-apnea-as-an-important-mechanism-for-sudep-a-near-sudep-with-continuous-eeg-ecg-emg-recording
#11
Lang Jin, Ying Zhang, Xiao-Li Wang, Wen-Juan Zhang, Yong-Hong Liu, Zhao Jiang
Sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death among patients with epilepsy. Most SUDEP or near-SUDEP are unwitnessed and not observed or recorded during video-EEG recording in epilepsy monitoring units. This report describes a young woman with post ictal apnea and generalized EEG suppression (PGES) after a secondary generalized tonic-clonic seizure (sGTCS). This was accompanied by bradycardia and then ventricular tachycardia (VT). But at the end of VT, the patient's breath recovered without any intervention, such as cardio-respiratory resuscitation...
September 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28555759/postictal-generalized-eeg-suppression-and-respiratory-dysfunction-following-generalized-tonic-clonic-seizures-in-sleep-and-wakefulness
#12
Weifeng Peng, Jessica L Danison, Masud Seyal
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a common cause of death in epilepsy and frequently occurs following generalized tonic-clonic seizures (GTCS) in sleep. Postictal generalized electroencephalography (EEG) suppression (PGES), postictal immobility, and periictal respiratory dysfunction are potential risk factors for SUDEP. We sought to determine whether there was a difference in respiratory dysfunction, PGES, and postictal immobility for GTCS occurring during wakefulness or sleep...
August 2017: Epilepsia
https://www.readbyqxmd.com/read/28506876/role-of-prostacyclin-synthase-in-carcinogenesis
#13
REVIEW
Yuka Sasaki, Tsubasa Ochiai, Masaya Takamura, Yukihiro Kondo, Chieko Yokoyama, Shuntaro Hara
Prostacyclin (PGI2) synthase (PGIS) and microsomal prostaglandin (PG) E synthase-1 (PGES-1) functionally couple with inducible cyclooxygenase-2 (COX-2) as their upstream enzymes to produce PGI2 and PGE2, respectively. Non-steroidal anti-inflammatory drugs exert their pharmacological effects including antitumor effects by the inhibition of COX-2 and thereby suppress this PG biosynthesis. PGIS is abundantly expressed in vascular endothelial and smooth muscle cells and was shown to be critical for the regulation of platelet aggregation and vascular tone...
May 12, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28415412/graphene-oxide-modified-single-use-electrodes-and-their-application-for-voltammetric-mirna-analysis
#14
Deniz Isin, Ece Eksin, Arzum Erdem
The modification of graphene oxide (GO) onto the surfaces of chemically activated pencil graphite electrodes (PGEs) was performed herein, and then these electrodes were applied for the first time on voltammetric monitoring of miRNAs. The specific recognition of miRNA-34a, which has been related to Alzheimer disease, was explored in the presence of DNA-RNA hybridization by using CA/GO/PGEs in combination with differential pulse voltammetry (DPV) technique. The characterization of CA/GO/PGE was investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28392405/prostaglandin-synthases-molecular-characterization-and-involvement-in-prostaglandin-biosynthesis
#15
REVIEW
Min-Ju Seo, Deok-Kun Oh
Prostaglandins (PGs) belong to a subclass of eicosanoids and are classified based on the structures of the cyclopentane ring and their number of double bonds in their hydrocarbon structures. PGs are important lipid mediators that are involved in inflammatory response. The biosynthesis of diverse PGs from unsaturated C20 fatty acids containing at least three double bonds such as dihomo-γ-linoleic acid (20:3(Δ8Z,11Z,14Z)), arachidonic acid (20:4(Δ5Z,8Z,11Z,14Z)), and eicosapentaenoic acid (20:5(Δ5Z,8Z,11Z,14Z,17Z)) is enables by various PG synthases, including prostaglandin H synthase (PGHS), 15-hydroxyprostaglandin dehydrogenase (15-HPGD), PGES, PGDS, PGFS, PGIS, and thromboxane A synthase (TXAS)...
April 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28380395/equivocal-significance-of-post-ictal-generalized-eeg-suppression-as-a-marker-of-sudep-risk
#16
Joon Y Kang, Amin H Rabiei, Leslie Myint, Maromi Nei
PURPOSE: Our objective was to determine the significance of PGES as a possible EEG marker of increased risk for SUDEP and explore factors that influence PGES. METHODS: We identified 17 patients who died due to definite or probable SUDEP and 52 living control patients with drug resistant focal epilepsy who underwent EEG monitoring and least one seizure recorded on EEG. We reviewed 305 seizures on EEG and when available, on video, for presence or absence of PGES, the duration of PGES immediately after seizure end, seizure type, state seizure occurred (sleep vs...
May 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28315002/determination-of-platinum-group-elements-in-particulate-matter-by-inductively-coupled-plasma-mass-spectrometry
#17
Jasmina Rinkovec, Gordana Pehnec, Silva Žužul, Sanda Rončević
This study examined a method for determination of rhodium (Rh), palladium (Pd) and platinum (Pt) in particulate matter using standard solutions, model samples and certified reference materials (NIST 1648a and ERM CZ120). The method was based on microwave digestion followed by inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the stability of the standard solution mixture of Rh, Pd and Pt was better when chlorides were present in the solution. A membrane filter and one type of quartz filter were the most adequate for analyzing platinum group elements (PGE)...
May 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28258428/ecotoxicological-characterization-of-polyoxyethylene-glycerol-ester-non-ionic-surfactants-and-their-mixtures-with-anionic-and-non-ionic-surfactants
#18
Francisco Ríos, Alejandro Fernández-Arteaga, Manuela Lechuga, Mercedes Fernández-Serrano
This paper reports on a study that investigated the aquatic toxicity of new non-ionic surfactants derived from renewable raw materials, polyoxyethylene glycerol ester (PGE), and their binary mixtures with anionic and non-ionic surfactants. Toxicity of pure PGEs was determined using representative organisms from different trophic levels: luminescent bacteria (Vibrio fischeri), microalgae (Pseudokirchneriella subcapitata), and freshwater crustaceans (Daphnia magna). Relationships between toxicity and the structural parameters such as unit of ethylene oxide (EO) and hydrophilic-lipophilic balance (HLB) were evaluated...
April 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28255500/pencil-graphite-electrodes-a-versatile-tool-in-electroanalysis
#19
REVIEW
Iulia Gabriela David, Dana-Elena Popa, Mihaela Buleandra
Due to their electrochemical and economical characteristics, pencil graphite electrodes (PGEs) gained in recent years a large applicability to the analysis of various types of inorganic and organic compounds from very different matrices. The electrode material of this type of working electrodes is constituted by the well-known and easy commercially available graphite pencil leads. Thus, PGEs are cheap and user-friendly and can be employed as disposable electrodes avoiding the time-consuming step of solid electrodes surface cleaning between measurements...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28214748/electrochemical-monitoring-of-biointeraction-by-graphene-based-material-modified-pencil-graphite-electrode
#20
Ece Eksin, Erhan Zor, Arzum Erdem, Haluk Bingol
Recently, the low-cost effective biosensing systems based on advanced nanomaterials have received a key attention for development of novel assays for rapid and sequence-specific nucleic acid detection. The electrochemical biosensor based on reduced graphene oxide (rGO) modified disposable pencil graphite electrodes (PGEs) were developed herein for electrochemical monitoring of DNA, and also for monitoring of biointeraction occurred between anticancer drug, Daunorubicin (DNR), and DNA. First, rGO was synthesized chemically and characterized by using UV-Vis, TGA, FT-IR, Raman Spectroscopy and SEM techniques...
June 15, 2017: Biosensors & Bioelectronics
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