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https://www.readbyqxmd.com/read/28214748/electrochemical-monitoring-of-biointeraction-by-graphene-based-material-modified-pencil-graphite-electrode
#1
Ece Eksin, Erhan Zor, Arzum Erdem, Haluk Bingol
Recently, the low-cost effective biosensing systems based on advanced nanomaterials have received a key attention for development of novel assays for rapid and sequence-specific nucleic acid detection. The electrochemical biosensor based on reduced graphene oxide (rGO) modified disposable pencil graphite electrodes (PGEs) were developed herein for electrochemical monitoring of DNA, and also for monitoring of biointeraction occurred between anticancer drug, Daunorubicin (DNR), and DNA. First, rGO was synthesized chemically and characterized by using UV-Vis, TGA, FT-IR, Raman Spectroscopy and SEM techniques...
February 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28213234/dna-wrapped-multi-walled-carbon-nanotube-modified-electrochemical-biosensor-for-the-detection-of-escherichia-coli-from-real-samples
#2
Dilsat Ozkan-Ariksoysal, Yasin Ugur Kayran, Fethiye Ferda Yilmaz, Anton Alexandru Ciucu, Iulia Gabriela David, Vasile David, Mine Hosgor-Limoncu, Mehmet Ozsoz
This paper introduces DNA-wrapped multi-walled carbon nanotube (MWCNT)-modified genosensor for the detection of Escherichia coli (E. coli) from polymerase chain reaction (PCR)-amplified real samples while Staphylococcus aureus (S. aureus) was used to investigate the selectivity of the biosensor. The capture probe specifically recognizing E. coli DNA and it was firstly interacted with MWCNTs for wrapping of single-stranded DNA (ssDNA) onto the nanomaterial. DNA-wrapped MWCNTs were then immobilised on the surface of disposable pencil graphite electrode (PGE) for the detection of DNA hybridization...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28086912/wwl70-attenuates-pge2-production-derived-from-2-arachidonoylglycerol-in-microglia-by-abhd6-independent-mechanism
#3
Mikiei Tanaka, Sean Moran, Jie Wen, Kwame Affram, Tinghua Chen, Aviva J Symes, Yumin Zhang
BACKGROUND: α/β-Hydrolase domain 6 (ABHD6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-AG) hydrolysis in microglia cells. Our recent studies have shown that a selective ABHD6 inhibitor WWL70 has anti-inflammatory and neuroprotective effects in animal models of traumatic brain injury and multiple sclerosis. However, the role of ABHD6 in the neuroinflammatory response and the mechanisms by which WWL70 suppresses inflammation has not yet been elucidated in reactive microglia...
January 10, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28043376/disorders-in-barrier-protein-mrna-expression-and-placenta-secretory-activity-under-the-influence-of-polychlorinated-biphenyls-in%C3%A2-vitro
#4
A Wojciechowska, J Mlynarczuk, J Kotwica
Pregnancy disorders are often correlated with the presence of organic pollutants in the tissues of living bodies. The aim of this study was to investigate the effects (over 24 and 48 hours) of polychlorinated biphenyls (PCBs) 153, 126, and 77 at doses of 1, 10, and 100 ng/mL on barrier function and secretory activity in cow placentome sections collected during the second trimester of pregnancy. None of the PCBs affected the viability of the sections (P > 0.05). Polychlorinated biphenyl 153 decreased (P < 0...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/27894940/changes-in-the-mrna-expression-of-structural-proteins-hormone-synthesis-and-secretion-from-bovine-placentome-sections-after-ddt-and-dde-treatment
#5
A Wojciechowska, J Mlynarczuk, J Kotwica
Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metabolite 1,1-dichloro-2,2-bis-4-chlorophenyl-ethene (DDE) (for 24 or 48h) at doses of 1, 10 or 100ng/ml on the function of cow placentome sections in the second trimester of pregnancy. DDT and DDE affected neither (P>0...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27824861/identification-of-biomarkers-of-impaired-sensory-profiles-among-autistic-patients
#6
Afaf El-Ansary, Wail M Hassan, Hanan Qasem, Undurti N Das
BACKGROUND: Autism is a neurodevelopmental disorder that displays significant heterogeneity. Comparison of subgroups within autism, and analyses of selected biomarkers as measure of the variation of the severity of autistic features such as cognitive dysfunction, social interaction impairment, and sensory abnormalities might help in understanding the pathophysiology of autism. METHODS AND PARTICIPANTS: In this study, two sets of biomarkers were selected. The first included 7, while the second included 6 biomarkers...
2016: PloS One
https://www.readbyqxmd.com/read/27816460/cuprac-colorimetric-and-electroanalytical-methods-determining-antioxidant-activity-based-on-prevention-of-oxidative-dna-damage
#7
Seda Uzunboy, Sema Demirci Çekiç, Ece Eksin, Arzum Erdem, Reşat Apak
An unbalanced excess of oxygen/nitrogen species (ROS/RNS) can give oxidative hazard to DNA and other biomacromolecules under oxidative stress conditions. While the 'comet' assay for measuring DNA damage is neither specific nor practical, monitoring oxidative changes on individual DNA bases and other oxidation products needs highly specialized equipment and operators. Thus, we developed a modified CUPRAC (cupric ion reducing antioxidant capacity) colorimetric method to determine the average total damage on DNA produced by Fenton oxidation, taking advantage of the fact that the degradation products of DNA but not the original macromolecule is CUPRAC-responsive...
February 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/27733774/time-lagging-interplay-effect-and-excess-risk-of-meteorological-mosquito-parameters-and-petrochemical-gas-explosion-on-dengue-incidence
#8
Ko Chang, Chaur-Dong Chen, Chien-Ming Shih, Tzu-Chi Lee, Ming-Tsang Wu, Deng-Chyang Wu, Yen-Hsu Chen, Chih-Hsing Hung, Meng-Chieh Wu, Chun-Chi Huang, Chien-Hung Lee, Chi-Kung Ho
In Kaohsiung, a metropolitan city in Taiwan at high risk of dengue epidemic, weather factors combined with an accidental petrochemical gas explosion (PGE) may affect mosquito‒human dynamics in 2014. Generalized estimating equations with lagged-time Poisson regression analyses were used to evaluate the effect of meteorological/mosquito parameters and PGE on dengue incidences (2000-2014) in Kaohsiung. Increased minimum temperatures rendered a 2- and 3-month lagging interactive effect on higher dengue risks, and higher rainfall exhibited a 1- and 2-month lagging interplay effect on lower risks (interaction, P ≤ 0...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27563731/effects-of-tio2-and-tic-nanofillers-on-the-performance-of-dye-sensitized-solar-cells-based-on-the-polymer-gel-electrolyte-of-a-cobalt-redox-system
#9
Shanmuganathan Venkatesan, I-Ping Liu, Li-Tung Chen, Yi-Chen Hou, Chiao-Wei Li, Yuh-Lang Lee
Polymer gel electrolytes (PGEs) of cobalt redox system are prepared for dye sensitized solar cell (DSSC) applications. Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) is used as a gelator of an acetonitrile (ACN) liquid electrolyte containing tris(2,2'-bipyridine)cobalt(II/III) redox couple. Titanium dioxide (TiO2) and titanium carbide (TiC) nanoparticles are utilized as nanofillers (NFs) of this PGE, and the effects of the two NFs on the conductivity of the PGEs, charge-transfer resistances at the electrode/PGE interface, and the performance of the gel-state DSSCs are studied and compared...
September 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27536525/anthropogenic-platinum-group-element-pt-pd-rh-concentrations-in-pm10-and-pm2-5-from-kolkata-india
#10
Huey Ting Diong, Reshmi Das, Bahareh Khezri, Bijayen Srivastava, Xianfeng Wang, Pradip K Sikdar, Richard D Webster
This study investigates platinum group elements (PGEs) in the breathable (PM10) and respirable (PM2.5) fractions of air particulates from a heavily polluted Indian metro city. The samples were collected from traffic junctions at the heart of the city and industrial sites in the suburbs during winter and monsoon seasons of 2013-2014. PGE concentrations were determined by inductively coupled plasma-mass spectrometry (ICP-MS). The PGE concentrations in the samples from traffic junctions are within the range of 2...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27494359/local-brain-activity-persists-during-apparently-generalized-postictal-eeg-suppression
#11
Dirk-Matthias Altenmüller, Andreas Schulze-Bonhage, Christian E Elger, Rainer Surges
OBJECTIVES: Postictal generalized EEG suppression (PGES) frequently occurs after generalized convulsive seizures (GCS) and may be involved in the pathophysiology of sudden unexpected death in epilepsy (SUDEP). It is usually determined using conventional scalp EEG which is likely to miss cerebral activity in deeper brain structures. Here, we examined intracranial EEG activity after GCS to unravel the pattern and extent of local brain activity during apparent PGES on scalp EEG (s-PGES)...
September 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27488032/the-effect-of-coumestrol-on-progesterone-and-prostaglandin-production-in-the-mare-in-vitro-and-in-vivo-studies
#12
Anna Z Szóstek, Agnieszka Sadowska, Katarzyna K Piotrowska-Tomala, Marta Botelho, Maria João Fradinho, Maria Rosa Rebordão, Graça M Ferreira-Dias, Dariusz J Skarzynski
Coumestrol (Cou) is a plant-derived phytoestrogen that induces various pathologies in the female reproductive tract. Although effects of phytoestrogens on reproductive function in other species are well documented, their influence on progesterone (P4) and prostaglandin (PG) secretion in the mare is unknown. The aim of this study was to determine if Cou directly affects P4 and PG concentrations (in vivo) and endometrial PG secretion (in vitro) in the mare. In Experiment 1, the mares (n=4) were fed for 14 days with a diet containing increasing proportions of alfalfa pellets (250 g to 1 kg/day)...
August 3, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27477116/ppar-ligand-association-with-prostaglandin-f2%C3%AE-and-e2-synthesis-in-the-pig-corpus-luteum-an-in-vitro-study
#13
A Kurzynska, K Chojnowska, M Bogacki, I Bogacka
The present study evaluated the involvement of PPARs in prostaglandin (PG) E2 and F2α production in the corpus luteum (CL) of pigs on days 10-12 and 14-16 of the estrous cycle or pregnancy. The tissue explants were incubated for 6h in the presence of PPARα, PPARβ, PPARγ ligands. The concentration of PGs in the incubation media was determined by radioimmunoassay, while mRNA abundance of PG synthetases (PGES and PGFS) was analyzed by quantitative real-time PCR. It was found that L-165,045 and rosiglitazone stimulated PGES synthesis on days 10-12 of the estrous cycle, whereas all factors that were assessed did not affect PGE2 release...
September 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27431225/emergence-and-plasmid-analysis-of-klebsiella-pneumoniae-kp01-carrying-blages-5-from-guangzhou-china
#14
Ding-Qiang Chen, Ai-Wu Wu, Ling Yang, Dan-Hong Su, Yong-Ping Lin, Yan-Wei Hu, Lei Zheng, Qian Wang
Klebsiella pneumoniae strain KP01 carrying blaGES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned blaGES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array of orf28-orf28-blaGES-5 was identified on pGES-GZ, within which orf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27357326/automated-video-detection-of-epileptic-convulsion-slowing-as-a-precursor-for-post-seizure-neuronal-collapse
#15
Stiliyan N Kalitzin, Prisca R Bauer, Robert J Lamberts, Demetrios N Velis, Roland D Thijs, Fernando H Lopes Da Silva
Automated monitoring and alerting for adverse events in people with epilepsy can provide higher security and quality of life for those who suffer from this debilitating condition. Recently, we found a relation between clonic slowing at the end of a convulsive seizure (CS) and the occurrence and duration of a subsequent period of postictal generalized EEG suppression (PGES). Prolonged periods of PGES can be predicted by the amount of progressive increase of interclonic intervals (ICIs) during the seizure. The purpose of the present study is to develop an automated, remote video sensing-based algorithm for real-time detection of significant clonic slowing that can be used to alert for PGES...
December 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27179861/novel-concepts-on-the-role-of-prostaglandins-on-luteal-maintenance-and-maternal-recognition-and-establishment-of-pregnancy-in-ruminants
#16
Joe A Arosh, Sakhila K Banu, John A McCracken
In ruminants, the corpus luteum (CL) of early pregnancy is resistant to luteolysis. Prostaglandin (PG)E2 is considered a luteoprotective mediator. Early studies indicate that during maternal recognition of pregnancy (MRP) in ruminants, a factor(s) from the conceptus or gravid uterus reaches the ovary locally through the utero-ovarian plexus (UOP) and protects the CL from luteolysis. The local nature of the embryonic antiluteolytic or luteoprotective effect precludes any direct effect of a protein transported or acting between the gravid uterus and CL in ruminants...
July 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27043176/non-microbial-sources-of-microbial-volatile-organic-compounds
#17
Hyunok Choi, Norbert Schmidbauer, Carl-Gustaf Bornehag
BACKGROUND: The question regarding the true sources of the purported microbial volatile organic compounds (MVOCs) remains unanswered. OBJECTIVE: To identify microbial, as well as non-microbial sources of 28 compounds, which are commonly accepted as microbial VOCs (i.e. primary outcome of interest is Σ 28 VOCs). METHODS: In a cross-sectional investigation of 390 homes, six building inspectors assessed water/mold damage, took air and dust samples, and measured environmental conditions (i...
July 2016: Environmental Research
https://www.readbyqxmd.com/read/27035829/effects-of-1-25-dihydroxy-vitamin-d3-on-endometriosis
#18
Mariko Miyashita, Kaori Koga, Gentaro Izumi, Fusako Sue, Tomoko Makabe, Ayumi Taguchi, Miwako Nagai, Yoko Urata, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
CONTEXT: Endometriosis is an estrogen-dependent, chronic inflammatory disease. Recent studies have shown that vitamin D (VD) is an effective modulator of the immune system and plays an important role in controlling many inflammatory diseases. OBJECTIVE: The objective of the study was to clarify the in vitro effects of 1,25-dihydroxy vitamin D3 (1,25[OH]2D3) on human endometriotic stromal cells (ESCs) and to determine the serum levels of VD in endometriosis patients...
June 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27033056/misoprostol-reverse-hippocampal-neuron-cyclooxygenase-2-downstream-signaling-imbalance-in-aluminum-overload-rats
#19
Yuanxin Guo, Wenjuan Lei, Jianfeng Wang, Xinyue Hu, Yuling Wei, Chaonan Ji, Junqing Yang
Although COX-2 inhibition in animal models of neurodegenerative diseases has shown neuroprotection, recent studies have revealed some serious side effects (ulcers, bleeding, fatal cerebrovascular diseases etc.) and the limited benefits of COX-2 inhibitors. A more focused approach is necessary to explore the therapeutic effect of the COX downstream signaling pathway in neurological research. The aim of this study was to explore the alterations of the PGES-PGE2-EP signal pathway and the effect of misoprostol on neurodegeneration by chronic aluminum-overload in rats...
2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27013739/chondroitin-sulfate-immobilized-on-a-biomimetic-scaffold-modulates-inflammation-while-driving-chondrogenesis
#20
Bruna Corradetti, Francesca Taraballi, Silvia Minardi, Jeffrey Van Eps, Fernando Cabrera, Lewis W Francis, Salvatore A Gazze, Mauro Ferrari, Bradley K Weiner, Ennio Tasciotti
UNLABELLED: Costs associated with degenerative inflammatory conditions of articular cartilage are exponentially increasing in the aging population, and evidence shows a strong clinical need for innovative therapies. Stem cell-based therapies represent a promising strategy for the treatment of innumerable diseases. Their regenerative potential is undeniable, and it has been widely exploited in many tissue-engineering approaches, especially for bone and cartilage repair. Their immune-modulatory capacities in particular make stem cell-based therapeutics an attractive option for treating inflammatory diseases...
May 2016: Stem Cells Translational Medicine
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