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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/29664764/epstein-barr-virus-high-risk-human-papillomavirus-and-abnormal-cervical-cytology-in-a-prospective-cohort-of-african-female-sex-workers
#1
Jennifer E Cameron, Anne F Rositch, Nadja A Vielot, Nelly R Mugo, Jessie K L Kwatampora, Wairimu Waweru, Aubrey E Gilliland, Michael E Hagensee, Jennifer S Smith
BACKGROUND: High oncogenic-risk human papillomavirus (hrHPV) is necessary, although insufficient, to promote cervical cancer. Like HPV, Epstein-Barr virus (EBV) is a common pathogen with the capacity to promote epithelial neoplasms. We examined the association between cervical EBV, hrHPV, and cytology in female sex workers in Nairobi, Kenya. METHODS: Women (n=332) with known cervical cytology and hrHPV mRNA results were evaluated for cervical EBV DNA by conventional PCR...
April 17, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29659762/activation-of-%C3%AF-20-dependent-recombination-and-horizontal-gene-transfer-in-mycoplasma-genitalium
#2
Sergi Torres-Puig, Carlos Martínez-Torró, Ignasi Granero-Moya, Enrique Querol, Jaume Piñol, Oscar Q Pich
In the human pathogen Mycoplasma genitalium, homologous recombination is under the control of σ20, an alternative sigma factor that boosts the generation of genetic and antigenic diversity in the population. Under laboratory growth conditions, σ20 activation is rare and the factors governing its intermittent activity are unknown. Two σ20-regulated genes, rrlA and rrlB, showed to be important for recombination of homologous DNA sequences in this bacterium. Herein, we demonstrate that rrlA and rrlB code for two small proteins that participate in a feed-forward loop essential for σ20 function...
April 11, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29620787/distribution-of-genital-mollicutes-in-the-vaginal-ecosystem-of-women-with-different-clinical-conditions
#3
Claudio Foschi, Melissa Salvo, Antonietta D'Antuono, Valeria Gaspari, Nicoletta Banzola, Roberto Cevenini, Antonella Marangoni
Ureaplasma urelayticum (UU), Ureaplasma parvum (UP), Mycoplasma hominis (MH) and Mycoplasma genitalium (MG) are the most common Mollicutes of the female genital tract. Although many studies have addressed their possible role in the vaginal ecosystem, many aspects remain to be elucidated. The aim of this study was to evaluate the vaginal presence of ureaplasmas/mycoplasmas in women with different clinical conditions. By means of quantitative PCR assays, the prevalence and load of each Mollicute were assessed in different groups of pre-menopausal women: 'healthy' (n=29), women with bacterial vaginosis (BV) (n=21), patients with Chlamydia trachomatis (CT) infection (n=25) and subjects with vulvo-vaginal candidiasis (VVC) (n=23)...
April 5, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29619908/prevalence-of-sexually-transmitted-diseases-in-asymptomatic-renal-transplant-recipients
#4
Mehmet Sarier, Nevgun Sepin Ozen, Hicran Guler, Ibrahim Duman, Yücel Yüksel, Sabri Tekin, Asuman Havva Yavuz, Levent Yucetin, Mine Erdogan Yilmaz
OBJECTIVES: Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays. MATERIALS AND METHODS: This prospective controlled study was conducted between November 2016 and January 2017 in our hospital...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29599387/clinical-and-sexual-risk-correlates-of-mycoplasma-genitalium-in-urban-pregnant-and-non-pregnant-young-women-cross-sectional-outcomes-using-the-baseline-data-from-the-women-s-biohealth-study
#5
Maria Trent, Jenell S Coleman, Justin Hardick, Jamie Perin, Lisa Tabacco, Steven Huettner, Jocelyn Ronda, Rebecca Felter-Wernsdorfer, Charlotte A Gaydos
OBJECTIVE: Research exploring the clinical and sexual risk correlates is essential to define universal standards for screening and management for Mycoplasma genitalium (MG). The objective of this study is to determine the baseline prevalence of MG and associated clinical risks using cross-sectional data. METHODS: Adolescent and young adult women 13-29 years were recruited during clinical visits during which biological specimens were collected for Neisseriagonorrhoeae (NG) and Chlamydia trachomatis (CT) testing to provide vaginal specimens for MG and Trichomonasvaginalis (TV) testing...
March 29, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29567802/-mycoplasma-genitalium-high-prevalence-of-resistance-to-macrolides-and-frequent-anorectal-infection-in-men-who-have-sex-with-men-in-western-sydney
#6
Deborah L Couldwell, Dean Jalocon, Melissa Power, Neisha J Jeoffreys, Sharon C-A Chen, David A Lewis
OBJECTIVES: We aimed to estimate the prevalence of Mycoplasma genitalium infection and of mutations linked to macrolide resistance using the ResistancePlus MG assay (SpeeDx, Sydney, New South Wales, Australia) in first-void urine (FVU), anorectal and oropharyngeal samples from men who have sex with men (MSM) attending Western Sydney Sexual Health Centre (WSSHC). METHODS: Consecutive symptomatic and asymptomatic MSM attending for STI testing were prospectively enrolled...
March 22, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29564244/prevalence-of-mycoplasma-genitalium-and-other-sexually-transmitted-pathogens-among-high-risk-individuals-in-greece
#7
Paraskevi Chra, Joseph Papaparaskevas, Eleni Papadogeorgaki, George Panos, Michalis Leontsinidis, George Arsenis, Athanassios Tsakris
Background: The aim of the present study was to determine the prevalence of Mycoplasma genitalium (MG) infection among individuals at high risk for sexually-transmitted diseases (STDs) at a major urban STD clinic in Athens, in view of the lack of data pertaining to this infection in Greece. Methods: Urethral and cervical samples from 176 individuals consecutively attending the clinic and agreeing to participate were prospectively collected and tested for MG infection using conventional PCR and TaqMan Real-Time PCR...
March 2018: Germs
https://www.readbyqxmd.com/read/29563165/risk-factors-for-mycoplasma-genitalium-endometritis-and-incident-infection-a-secondary-data-analysis-of-the-t-cell-response-against-chlamydia-trac-study
#8
Brandie D Taylor, Xiaojing Zheng, Catherine M O'Connell, Harold C Wiesenfeld, Sharon L Hillier, Toni Darville
OBJECTIVE: Assess risk factors for incident and endometrial Mycoplasma genitalium infection and determine if M. genitalium is associated with histological endometritis, an indicator of pelvic inflammatory disease. METHODS: This study was a secondary data analysis within the T cell Response Against Chlamydia (TRAC) Study, a prospective evaluation of 246 women with or at risk for Chlamydia trachomatis from urban outpatient clinics, who were followed quarterly for 12 months...
March 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29559392/identifying-a-consensus-sample-type-to-test-for-chlamydia-trachomatis-neisseria-gonorrhoeae-mycoplasma-genitalium-trichomonas-vaginalis-and-human-papillomavirus
#9
Liselotte Coorevits, Ans Traen, Luk Bingé, Jo Van Dorpe, Marleen Praet, Jerina Boelens, Elizaveta Padalko
OBJECTIVES: Sexually transmitted infections (STIs) are a global cause of acute illness. Early detection plays a crucial role in interrupting transmission and preventing complications. However, the accessibility of STI testing is curbed by the lack of an overall preferred sample type. By means of a prospective study in female sex workers (FSW), we compared the sensitivity of samples from different anatomical sites in detecting Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium and human papillomavirus...
March 17, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29553074/-validation-of-the-kit-for-detecting-mycoplasma-genitalium-from-the-male-urethritis
#10
Ryoichi Hamasuna, Masahiro Matsumoto, Phuong Thi LE, Naohiro Fujimoto, Tetsuro Matsumoto
Mycoplasma genitalium is one of the pathogenic microorganisms in male urethritis as a sexually transmitted infection (STI). M.genitalium is detected in the urine specimens of 15-25% male patients with urethritis. The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide, but there is no commercial-based detecting kits accepted by the national insurance in Japan. In this study, we tested the validity of a molecular kit for detecting seven microorganisms related to STI (Anyplex™ II STI-7 Detection which detects Neisseria gonorrhoeae, Chlamydia trachomatis, M...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29551599/cyclophilin-a-is-the-potential-receptor-of-the-mycoplasma-genitalium-adhesion-protein
#11
Xiangying Deng, Pei Dai, Minjun Yu, Liesong Chen, Cuiming Zhu, Xiaoxing You, Lingling Li, Yanhua Zeng
The Mycoplasma genitalium adhesion protein (MgPa), the most important outer membrane protein of M. genitalium, plays a vital role in the adhesion to and invasion of host cells by M. genitalium. Identification of MgPa receptors will help elucidate the pathogenic mechanism of M. genitalium. However, the receptor protein of MgPa has not been reported to date. In this study, an MgPa-binding protein with a molecular weight of approximately 17 kDa was screened from SV-HUC-1 cell membrane proteins by a modified virus overlay protein binding assay (VOPBA)...
March 12, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29541667/data-independent-proteome-profile-of-mycoplasma-gallisepticum-under-normal-conditions-and-heat-stress
#12
Ivan Butenko, Olga Pobeguts, Daria Matyushkina, Sergey Kovalchuk, Nickolay Anikanov, Gleb Fisunov, Vadim Govorun
The data reported is a large-scale untargeted proteome profile for Mycoplasma gallisepticum - a model organism for studying both regulation in genome-reduced bacteria and intracellular infection (Mazin et al., 2014) [1,2]. While seminal whole-proteome studies were performed on Mycoplasma genitalium [3] and a few proteome datasets are available for Mycoplasma pneumoniae , no data-independent (DIA) proteome profiling has been published for bacteria of Mycoplasma genus. Since DIA-based proteome profiling allows to extract evidence on presence and quantity of any protein of interest in a post-acquisition manner and the data presented is describing a model which is suitable to study both proteome regulation in general and details of mycoplasma infection process [4], the proteome profiling data presented here is of value for deep annotation...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29530863/-in-vitro-activity-of-lefamulin-against-sexually-transmitted-bacterial-pathogens
#13
Susanne Paukner, Astrid Gruss, Jørgen Skov Jensen
The pleuromutilin antibiotic lefamulin demonstrated in vitro activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI) including Chlamydia trachomatis (MIC50/90 of 0.02/0.04 mg/L, n =15), susceptible and multidrug-resistant Mycoplasma genitalium (MIC range 0.002-0.063 mg/L, n =6) and susceptible and resistant Neisseria gonorrhoeae (MIC50/90 , 0.12/0.5 mg/L, n =25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high resistance rates to standard of care antibiotics...
March 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29520883/the-nucleotide-bound-substrate-bound-conformation-of-the-mycoplasma-genitalium-dnak-chaperone
#14
Maria Adell, Bárbara M Calisto, Ignacio Fita, Luca Martinelli
Hsp70 chaperones keep protein homeostasis facilitating the response of organisms to changes in external and internal conditions. Hsp70s have two domains - Nucleotide Binding Domain (NBD) and Substrate Binding Domain (SBD) - connected by a conserved hydrophobic linker. Functioning of Hsp70s depend on tightly regulated cycles of ATP hydrolysis allosterically coupled, often together with co-chaperones, to the binding/release of peptide substrates. Here we describe the crystal structure of the Mycoplasma genitalium DnaK (MgDnaK) protein, an Hsp70 homolog, in the non-compact, nucleotide-bound/substrate-bound conformation...
March 9, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29520664/association-between-genital-mycoplasmas-infection-and-human-papillomavirus-infection-abnormal-cervical-cytopathology-and-cervical-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Hui Ye, Tiange Song, Xi Zeng, Lin Li, Minmin Hou, Mingrong Xi
BACKGROUND: Some studies demonstrated that female genital mycoplasmas play important roles in human papillomavirus (HPV) infection, abnormal cervical cytopathology, and cervical cancer. However, those results remained inconclusive. We aimed to perform a systematic review and meta-analysis to investigate the association between female genital mycoplasmas and those disorders. METHODS: Computerized databases were comprehensively searched before 26 January 2017. Pooled odd radios (ORs) and correlative 95% confidence intervals (CIs) were adopted to evaluate the strength of association...
March 8, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29510884/evaluation-of-a-real-time-pcr-assay-for-detection-of-mycoplasma-genitalium-and-macrolide-resistance-mediating-mutations-from-clinical-specimens
#16
Li Xiao, Ken B Waites, Hong Wang, Barbara Van Der Pol, Amy E Ratliff, William M Geisler
Mycoplasma genitalium (MG) is a sexually transmitted pathogen for which there is no FDA-approved diagnostic test available in the United States. A modified real-time polymerase chain reaction assay for detecting MG and simultaneously identifying macrolide resistance mutations from clinical specimens was evaluated and proved to be sensitive and accurate for diagnostic purposes.
February 9, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29509566/prevalence-of-mycoplasma-genitalium-and-azithromycin-resistant-infections-among-remnant-clinical-specimens-los-angeles
#17
Lao-Tzu Allan-Blitz, Elisa Mokany, Shelley Miller, Rachel Wee, Chelsea Shannon, Jeffrey D Klausner
BACKGROUND: Mycoplasma genitalium is an important cause of bacterial sexually transmitted diseases. Diagnosis and susceptibility testing of Mycoplasma genitalium are limited by the fastidious nature of the organism. Therefore, the prevalence of infection and azithromycin resistance are poorly studied. METHODS: We conducted an exploratory study on remnant clinical specimens. We collected remnant DNA from urine samples and clinical swabs (cervical/vaginal, rectal, and pharyngeal) previously tested for Neisseria gonorrhoeae and Chlamydia trachomatis using the Cobas 4800 CT/NG assay (Roche Molecular Systems, Pleasanton, CA) between March-April 2017 from across the University of California, Los Angeles Health System...
March 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29487171/-mycoplasma-genitalium-an-important-sexually-transmitted-infection-comes-into-focus
#18
EDITORIAL
Joseph D Tucker, Jason J Ong
No abstract text is available yet for this article.
February 27, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29470847/cryo-electron-tomography-analyses-of-terminal-organelle-mutants-suggest-the-motility-mechanism-of-mycoplasma-genitalium
#19
Anja Seybert, Luis Gonzalez-Gonzalez, Margot P Scheffer, Maria Lluch-Senar, Ana M Mariscal, Enrique Querol, Franziska Matthaeus, Jaume Piñol, Achilleas S Frangakis
The terminal organelle of Mycoplasma genitalium is responsible for bacterial adhesion, motility and pathogenicity. Localized at the cell tip, it comprises an electron-dense core that is anchored to the cell membrane at its distal end and to the cytoplasm at its proximal end. The surface of the terminal organelle is also covered with adhesion proteins. We performed cellular cryo-electron tomography on deletion mutants of eleven proteins that are implicated in building the terminal organelle, in order to systematically analyse the ultrastructural effects...
February 22, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29465674/the-etiology-of-vaginal-discharge-syndrome-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#20
Z Mike Chirenje, Nicholas Dhibi, H Hunter Handsfield, Elizabeth Gonese, Beth Tippett Barr, Lovemore Gwanzura, Ahmed S Latif, Dumisili Venessa Maseko, Ranmini S Kularatne, Mufuta Tshimanga, Peter H Kilmarx, Anna Machiha, Owen Mugurungi, Cornelis A Rietmeijer
INTRODUCTION: Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STI) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines...
November 29, 2017: Sexually Transmitted Diseases
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