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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/28099135/mycoplasma-ureaplasma-infection-in-pregnancy-to-screen-or-not-to-screen
#1
Gilbert G G Donders, Kateryna Ruban, Gert Bellen, Ljubomir Petricevic
Mycoplasmata have been linked to pregnancy complications and neonatal risk. While formerly a limited number of species could be discovered by cultures, molecular biology nowadays discovers both lower quantities and more diverse species, making us realize that mycoplasmata are ubiquitous in the vaginal milieu and do not always pose a danger for pregnant women. As the meaning of mycoplasmata in pregnancy is not clear to many clinicians, we summarized the current knowledge about the meaning of different kinds of mycoplasmata in pregnancy and discuss the potential benefits and disadvantages of treatment...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28079749/should-female-partners-of-men-with-non-gonococcal-urethritis-negative-for-chlamydia-trachomatis-and-mycoplasma-genitalium-be-informed-and-treated-clinical-outcomes-from-a-partner-study-of-heterosexual-men-with-ngu
#2
Jason J Ong, Angela Sarumpaet, Eric P F Chow, Catriona Bradshaw, Marcus Chen, Tim Read, Christopher K Fairley
BACKGROUND: To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection. METHODS: Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28072403/antimicrobial-resistant-sexually-transmitted-infections-gonorrhoea-and-mycoplasma-genitalium
#3
REVIEW
Magnus Unemo, Jorgen S Jensen
The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro and clinically, to essentially all antimicrobials available for treatment, causing exceedingly difficult-to-treat or untreatable STIs and threatening global public health. Widespread AMR in these bacteria is likely to persist and even worsen in the future, owing to the high number of infections, widespread and uncontrolled use of antimicrobials, limited surveillance of AMR and clinical failures, as well as the extraordinary capacity of these bacteria to develop AMR...
January 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28032361/relationship-between-chlamydia-trachomatis-and-mycoplasma-genitalium-infection-and-pregnancy-rate-and-outcome-in-iranian-infertile-couples
#4
L Dehghan Marvast, A Aflatoonian, A R Talebi, A Eley, A A Pacey
The study was performed to investigate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in a population of infertile couples from Iran and how this relates to tubal factor infertility, pregnancy rate and outcome of pregnancy. Blood, semen and first-void urine samples were obtained from 250 infertile couples and 250 fertile women as a control. Infertile couples were followed up after 24 months to determine diagnosis, referral for assisted conception, any pregnancy and pregnancy outcome. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C...
December 29, 2016: Andrologia
https://www.readbyqxmd.com/read/28031435/evaluation-of-a-commercial-multiplex-qpcr-assay-for-simultaneous-detection-of-mycoplasma-genitalium-and-macrolide-resistance-associated-mutations-in-clinical-specimens
#5
Chloé Le Roy, Nadège Hénin, Cécile Bébéar, Sabine Pereyre
Macrolide antibiotics are the first-line treatment for Mycoplasma genitalium infections however macrolide resistance has increased up to 40% in several countries (1-3).….
December 28, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28011607/azithromycin-1-5g-over-5-days-compared-to-1g-single-dose-in-urethral-mycoplasma-genitalium-impact-on-treatment-outcome-and-resistance
#6
Tim R H Read, Christopher K Fairley, Sepehr N Tabrizi, Melanie Bissessor, Lenka Vodstrcil, Eric P F Chow, Mieken Grant, Jennifer Danielewski, Suzanne M Garland, Jane S Hocking, Marcus Y Chen, Catriona S Bradshaw
BACKGROUND: We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 and compared this to cases treated with azithromycin 1g in 2012-2013. METHODS: Microbiological cure was determined for men with M. genitalium urethritis treated with azithromycin 1.5g using quantitative polymerase chain reaction specific for M. genitalium DNA on samples 14-100 days post-treatment...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28007229/sexually-transmitted-diseases-and-infertility
#7
REVIEW
Danielle G Tsevat, Harold C Wiesenfeld, Caitlin Parks, Jeffrey F Peipert
Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27981387/-non-viral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostics-and-therapy-part%C3%A2-2-chlamydia-and-mycoplasma
#8
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
Chlamydia trachomatis is the most common pathogen of sexually transmitted bacterial infections worldwide. Every year in Germany approximately 300,000 new infections are to be expected. Chlamydia infections occur nearly exclusively in the postpubertal period. The peak age group is 15-25 years. The infection usually runs an asymptomatic course and the diagnosis is made by nucleic acid amplification techniques (NAAT) often after chlamydial screening or if complications occur. For treatment of chlamydial infections oral doxycycline 100 mg twice daily over 7 days is initially used or alternatively oral azithromycin 1...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27935945/correction-improved-metabolic-models-for-e-coli-and-mycoplasma-genitalium-from-globalfit-an-algorithm-that-simultaneously-matches-growth-and-non-growth-data-sets
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1005036.].
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27898565/quantitative-real-time-polymerase-chain-reaction-for-the-diagnosis-of-mycoplasma-genitalium-infection-in-south-african-men-with-and-without-symptoms-of-urethritis
#10
Marie Cecilia le Roux, Anwar Ahmed Hoosen
BACKGROUND: This study was done to diagnose Mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. METHODS: Urine specimens from 94 men with visible urethral discharge, 206 with burning on micturition and 75 without symptoms presenting to a family practitioner were tested for M. genitalium as well as Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis by transcription-mediated amplification assays...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27894204/clinical-laboratory-assessments-for-mycoplasma-genitalium-in-a-high-prevalence-sexually-transmitted-infection-community-reveal-epidemiologic-dichotomies-with-trichomonas-vaginalis
#11
Erik Munson, Kimber L Munson, Ronald F Schell
Mycoplasma genitalium is an emerging agent of sexually-transmitted infection and is responsible for clinically-significant genital tract disease in both females and males. Similar to scenarios recently experienced with the urogenital flagellate Trichomonas vaginalis, an evolving molecular diagnostic reference standard based on transcription-mediated amplification allows for accurate detection of the organism, plus additional insight into disease epidemiology. Areas covered. The basis for this article includes primary peer-reviewed literature plus compilations of data derived from routine clinical laboratory screening of females and males for agents of sexually-transmitted infection...
December 10, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27893600/prevalence-and-correlates-of-genital-infections-among-newly-diagnosed-human-immunodeficiency-virus-infected-adults-entering-human-immunodeficiency-virus-care-in-windhoek-namibia
#12
Gaston Djomand, Madeleine Schlefer, Steve Gutreuter, Sarah Tobias, Roopal Patel, Nickolas DeLuca, Julia Hood, Souleymane Sawadogo, Cheng Chen, Alexinah Muadinohamba, David W Lowrance, Naomi Bock
BACKGROUND: Identifying and treating genital infections, including sexually transmitted infections (STI), among newly diagnosed human immunodeficiency virus (HIV)-infected individuals may benefit both public and individual health. We assessed prevalence of genital infections and their correlates among newly diagnosed HIV-infected individuals enrolling in HIV care services in Namibia. METHODS: Newly diagnosed HIV-infected adults entering HIV care at 2 health facilities in Windhoek, Namibia, were recruited from December 2012 to March 2014...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27882384/prevalence-of-mycoplasma-genitalium-infection-and-relationship-with-symptoms-among-adults-attending-a-sexual-health-centre
#13
Maeva Lefebvre, Julie Coutherut, Sophie Gibaud, Charlotte Biron, Marine Chalopin, Claire Bernier, François Raffi
is missing (Short communication).
November 24, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27872239/experimental-infection-of-pig-tailed-macaques-macaca-nemestrina-with-mycoplasma-genitalium
#14
Gwendolyn E Wood, Dorothy L Patton, Peter K Cummings, Stefanie L Iverson-Cabral, Patricia A Totten
Mycoplasma genitalium is an underappreciated cause of human reproductive tract disease, characterized by persistent, often asymptomatic, infection. Building on our previous experiments using a single female pig-tailed macaque as a model for M. genitalium infection (G. E. Wood, S. L. Iverson-Cabral, D. L. Patton, P. K. Cummings, Y. T. Cosgrove Sweeney, and P. A. Totten, Infect Immun 81:2938-2951, 2013, doi: 10.1128/IAI.01322-12), we cervically inoculated eight additional animals, two of which were simultaneously inoculated in salpingeal tissue autotransplanted into abdominal pockets...
November 21, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27836808/mycoplasma-genitalium-and-trichomonas-vaginalis-in-france-a-point-prevalence-study-in-people-screened-for-sexually-transmitted-diseases
#15
Sabine Pereyre, Cécile Laurier Nadalié, Cécile Bébéar
OBJECTIVES: Mycoplasma genitalium and Trichomonas vaginalis are common causes of sexually transmitted infections but limited prevalence data are available in France. We aimed to evaluate the prevalence of M. genitalium and T. vaginalis infections and to assess prevalence by gender, age, sample collection sites and clinical symptoms. A multicentre collection of specimens was intended to obtain a nationwide overview of the epidemiology. METHODS: Between September 2014 and January 2015, 2652 consecutive urogenital specimens submitted to the microbiology diagnostic departments of 16 French university hospitals for Chlamydia trachomatis and Neisseria gonorrhoeae detection were collected...
November 8, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27829780/bacterial-load-in-daily-urine-samples-of-patients-infected-with-mycoplasma-genitalium-mutation-analysis-and-response-to-treatment
#16
M Gossé, S A Nordbø, B Pukstad
Objective. Increasing macrolide resistant strains of Mycoplasma genitalium is a challenge, and to differentiate between treatment failure and reinfection a timely test of cure (TOC) is warranted. The aim of this study was to evaluate the best time for TOC after five days' treatment of Mycoplasma genitalium infection with azithromycin. Methods. Nineteen patients with positive PCR for Mycoplasma genitalium in urine provided urine samples daily for 2 weeks and on days 21, 28, and 35. Samples were tested by a commercial qPCR and by sequencing of the 23S rRNA gene...
2016: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27812493/a-case-control-study-on-the-relationship-between-mycoplasma-genitalium-infection-in-women-with-normal-pregnancy-and-spontaneous-abortion-using-polymerase-chain-reaction
#17
Rashid Ramazanzadeh, Mazaher Khodabandehloo, Fariba Farhadifar, Samaneh Rouhi, Amjad Ahmadi, Shaho Menbari, Fariba Fallahi, Reza Mirnejad
OBJECTIVES: Mycoplasma genitalium infections are suggested as causes of a number of pathological outcomes in pregnant women. The aim of this study was to evaluate the frequency of M. genitalium infections among pregnant women and its association with spontaneous abortion. METHODS: In this case-control study we included 109 women with spontaneous abortion with a gestational age of 10-20 weeks (patients), and 109 women with normal pregnancy with a gestational age of 20-37 weeks (controls) in Sanandaj, Iran...
October 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/27797534/thermodynamics-of-macromolecular-association-in-heterogeneous-crowding-environments-theoretical-and-simulation-studies-with-a-simplified-model
#18
Tadashi Ando, Isseki Yu, Michael Feig, Yuji Sugita
The cytoplasm of a cell is crowded with many different kinds of macromolecules. The macromolecular crowding affects the thermodynamics and kinetics of biological reactions in a living cell, such as protein folding, association, and diffusion. Theoretical and simulation studies using simplified models focus on the essential features of the crowding effects and provide a basis for analyzing experimental data. In most of the previous studies on the crowding effects, a uniform crowder size is assumed, which is in contrast to the inhomogeneous size distribution of macromolecules in a living cell...
November 23, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27773499/-mycoplasma-genitalium
#19
I Alcaraz, N Dupin, M Janier, C Derancourt, B Milpied, A Bertolotti
No abstract text is available yet for this article.
November 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27756249/ureaplasma-parvum-genotype-combined-vaginal-colonisation-with-candida-albicans-and-spontaneous-preterm-birth-in-an-australian-cohort-of-pregnant-women
#20
Matthew S Payne, Demelza J Ireland, Rory Watts, Elizabeth A Nathan, Lucy L Furfaro, Matthew W Kemp, Jeffrey A Keelan, John P Newnham
BACKGROUND: Detection of Ureaplasma, Mycoplasma and Candida spp. in the vagina during pregnancy has previously been associated with preterm birth (PTB). However, the prevalence of these microorganisms and the associated obstetric risks (likely to be population-specific) have not been determined in Australian women; furthermore, in the case of Ureaplasma spp., very few studies have attempted characterisation at the species level and none have examined genotype/serovar status to further refine risk assessment...
October 18, 2016: BMC Pregnancy and Childbirth
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