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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/28608794/mycoplasma-genitalium-antibiotic-resistance-mediating-mutations-in-canadian-women-with-or-without-chlamydia-trachomatis-infection
#1
Max A Chernesky, Dan Jang, Irene Martin, Linda M N Hoang, Prenilla Naidu, Paul N Levett, John Wylie, Anu Rebbapragada, Sam Ratnam, Marek Smieja, Barbara Weinbaum, Damon Getman
Testing remnant Aptima specimens from women infected with Chlamydia trachomatis detected 13.4% (53/396) with Mycoplasma genitalium compared with 5.4% (22/406) in matched C. trachomatis-negative women. Overall, 9.4% (provincial ranges of 3-20%) were infected with M. genitalium and resistance mediating mutations were found in 47.3% (26/55) to macrolides and 1.9% (1/53) to fluoroquinolones by sequencing.
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28608793/the-immunopathogenesis-of-mycoplasma-genitalium-infections-in-women-a-narrative-review
#2
Patricia M Dehon, Chris L McGowin
Mycoplasma genitalium is a common, predominately asymptomatic, and often undiagnosed sexually transmitted infection that is associated with inflammatory urogenital and reproductive tract disease syndromes of men and women. Without programmatic screening in the United States, and with increasing resistance to antibiotics used in empiric sexually transmitted infection management, undiagnosed M. genitalium infections put many women at risk for cervicitis and pelvic inflammatory disease. Chronic infection may also lead to tubal-factor infertility, adverse pregnancy outcomes in expectant mothers, and is a risk factor for acquisition and transmission of human immunodeficiency virus...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28590237/evaluation-of-self-collected-rectal-swabs-for-the-detection-of-bacteria-responsible-for-sexually-transmitted-infections-in-a-cohort-of-hiv-1-infected-patients
#3
Sophie Edouard, Catherine Tamalet, Hervé Tissot-Dupont, Philippe Colson, Amélie Ménard, Isabelle Ravaux, Catherine Dhiver, Christelle Tomei, Andreas Stein, Didier Raoult
PURPOSE: The standard approach to screening sexually transmitted infections (STIs) has often been restricted to urogenital specimens. Most current guidelines, however, also recommend testing extra-genital sites, including rectal locations, because asymptomatic rectal carriage of pathogens has often been reported. The aim of our study was to evaluate self-collected rectal swabs to screen bacterial STIs in HIV-infected patients in Marseille, France. METHODOLOGY: Between January 2014 and December 2015, 118 HIV-infected patients (93 males and 25 females) agreed to self-sample anal swabs for detection of bacterial STI...
June 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28529540/the-potential-role-of-infectious-agents-and-pelvic-inflammatory-disease-in-ovarian-carcinogenesis
#4
REVIEW
Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall, Jan Blaakaer
BACKGROUND: The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM: To review the literature on studies examining the association between ovarian cancer and bacterial or viral infection or pelvic inflammatory disease. METHODS: Database search through MEDLINE, applying the medical subject headings: "Ovarian neoplasms", AND "Chlamydia infections", "Neisseria gonorrhoeae", "Mycoplasma genitalium", "Papillomaviridae", or "pelvic inflammatory disease"...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28472225/recent-bacterial-vaginosis-is-associated-with-acquisition-of-mycoplasma-genitalium
#5
Erica M Lokken, Jennifer E Balkus, James Kiarie, James P Hughes, Walter Jaoko, Patricia A Totten, R Scott McClelland, Lisa E Manhart
We assessed the association between recent bacterial vaginosis (BV) and incident Mycoplasma genitalium, a sexually transmitted bacterium associated with adverse female reproductive health outcomes. Female sex workers in Mombasa, Kenya completed a monthly sexual behavior interview and clinical examination. During February 2005-February 2006, vaginal fluid specimens collected from women every other month were tested for M. genitalium by nucleic acid amplification testing. Vaginal microbiota was assessed monthly and categorized by Nugent score (0-3 normal, 4-6 intermediate microbiota, 7-10 BV)...
May 3, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28468853/high-macrolide-resistance-in-mycoplasma-genitalium-strains-causing-infection-in-auckland-new-zealand
#6
Indira Basu, Sally A Roberts, James E Bower, Gillian Henderson, Murray Reid
Mycoplasma genitalium has been implicated as a cause of acute and chronic non-chlamydial non-gonococcal urethritis (NCNGU) and pelvic inflammatory disease (PID) (1).….
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28462860/emergence-of-mycoplasma-genitalium-with-clinically-significant-fluoroquinolone-resistance-conferred-by-amino-acid-changes-both-in-gyra-and-parc-in-japan
#7
Takashi Deguchi, Shin Ito, Mitsuru Yasuda, Hiromi Kondo, Yoshiteru Yamada, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano
We observed fluoroquinolone treatment failures in 2 men with Mycoplasma genitalium-positive non-gonococcal urethritis in Japan. A fluoroquinolone regimen of sitafloxacin 100 mg twice daily for 7 days failed to eradicate M. genitalium. In both cases, M. genitalium had fluoroquinolone resistance-associated amino acid changes both in GyrA and ParC and a macrolide resistance-associated mutation in the 23S rRNA gene. The emergence of such multi-drug resistant strains can threaten antimicrobial chemotherapy for M...
April 24, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28457846/women-with-symptoms-of-a-urinary-tract-infection-but-a-negative-urine-culture-pcr-based-quantification-of-escherichia-coli-suggests-infection-in-most-cases
#8
S Heytens, A De Sutter, L Coorevits, P Cools, J Boelens, L Van Simaey, T Christiaens, M Vaneechoutte, G Claeys
OBJECTIVES: Our objective was to examine whether or not women with symptoms of a urinary tract infection but with a negative culture (20%-30%) do have an infection. METHODS: We performed quantitative PCR (qPCR) for Escherichia coli and Staphylococcus saprophyticus, on top of a standard culture, in urine samples from 220 women with dysuria and/or frequency and/or urgency and from 86 women without symptoms. For symptomatic women, qPCR was also carried out for four sexually transmitted agents...
April 21, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28439608/isolation-of-mycoplasma-genitalium-from-endocervical-swabs-of-infertile-women
#9
Dunia A Alfarraj, Ali M Somily
To determine the occurrence of Mycoplasma genitalium (M. genitalium) infection in infertile women attending infertility clinic and its association to infertility. Methods: Endocervical specimens were collected from women presenting with primary and secondary infertility and from fertile women as control group. Real-time polymerase chain reaction (PCR)  assay was performed to detect the presence of M. genitalium from these endocervical specimens.  Results: Mycoplasma genitalium was detected in 3% of infertile women...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28438948/macrolide-and-quinolone-resistant-mycoplasma-genitalium-in-a-man-with-persistent-urethritis-the-tip-of-the-british-iceberg
#10
Suneeta Soni, Andy Parkhouse, Gillian Dean
There is growing concern worldwide for macrolide resistance in M. genitalium following liberal use of 1 g azithromycin to treat non-gonococcal urethritis and confirmed C. trachomatis infection. Moxifloxacin is the second-line treatment for M. genitalium and still has excellent efficacy against it. However, recent reports indicating that quinolone resistance is more prevalent than previously thought are worrying. Routine testing of symptomatic men and women for M. genitalium is not currently recommended in BASHH guidelines, and attempts to implement such testing have been hampered by a lack of commercially available assays...
April 24, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28418319/increasing-macrolide-and-fluoroquinolone-resistance-in-mycoplasma-genitalium
#11
Gerald L Murray, Catriona S Bradshaw, Melanie Bissessor, Jennifer Danielewski, Suzanne M Garland, Jørgen S Jensen, Christopher K Fairley, Sepehr N Tabrizi
Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28407014/prevalence-of-macrolide-and-fluoroquinolone-resistance-mediating-mutations-in-mycoplasma-genitalium-in-five-cities-in-russia-and-estonia
#12
Elena Shipitsyna, Tatiana Rumyantseva, Daniel Golparian, Guzel Khayrullina, Amaya C Lagos, Inna Edelstein, Kai Joers, Jörgen S Jensen, Alevtina Savicheva, Natalia Rudneva, Larisa Sukhanova, Roman Kozlov, Alexander Guschin, Magnus Unemo
BACKGROUND AND OBJECTIVE: Resistance in the sexually transmitted bacterium Mycoplasma genitalium to all recommended therapeutic antimicrobials have rapidly emerged. However, to date, internationally reported resistance surveillance data for M. genitalium strains circulating in Eastern Europe are entirely lacking. The aim of this study was to estimate the prevalence of macrolide and fluoroquinolone resistance-associated mutations in M. genitalium in four cities in Russia and one in Estonia, 2013-2016...
2017: PloS One
https://www.readbyqxmd.com/read/28381611/prospective-evaluation-of-resistanceplus-mg-a-new-multiplex-quantitative-pcr-assay-for-detection-of-mycoplasma-genitalium-and-macrolide-resistance
#13
S N Tabrizi, J Su, C S Bradshaw, C K Fairley, S Walker, L Y Tan, E Mokany, S M Garland
Mycoplasma genitalium is a significant pathogen for which first-line treatment is becoming less effective due to increased resistance to macrolides. As conventional culture and antimicrobial susceptibility testing is not feasible for routine detection of this pathogen, molecular markers such as detection of mutations in the 23S rRNA gene have been described to predict resistance. Recently, a novel multiplex quantitative PCR (qPCR) assay, ResistancePlus MG, has been described for the simultaneous detection of Mycoplasma genitalium and macrolide resistance...
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28377334/mycoplasma-genitalium-a-mycoplasma-still-underestimated
#14
Julie Plantamura, Christine Bigaillon, Aurore Bousquet, Déborah Delaune, Sébastien Larréché, Sarah Bugier, Audrey Mérens, Cécile Ficko
Three men referred to the emergency department with suspected sexually transmitted infection like urethritis. After collection of several clinical specimens, they are sent home with a probabilistic treatment. Mycoplasma genitalium research is performed in first line, as Neisseria gonorrhoeae and Chlamydia trachomatis, and comes back positive. Patients are recalled in order to evaluate probabilistic treatment efficiency. M. genitalium, still underestimated because of its recent discovery, is responsible for 10 to 35% of non gonococcal acute and chronical urethritis...
April 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28361246/multidrug-resistant-mycoplasma-genitalium-infections-in-europe
#15
J F Braam, L van Dommelen, C J M Henquet, J H B van de Bovenkamp, J G Kusters
In Japan and Australia, multidrug-resistant Mycoplasma genitalium infections are reported with increasing frequency. Although macrolide-resistant M. genitalium strains are common in Europe and North America, fluoroquinolone-resistant strains are still exceptional. However, an increase of multidrug-resistant M. genitalium in Europe and America is to be expected. The aim of this paper is to increase awareness on the rising number of multidrug-resistant M. genitalium strains. Here, one of the first cases of infection with a genetically proven multidrug-resistant M...
March 30, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28301989/routine-testing-of-mycoplasma-genitalium-and-trichomonas-vaginalis
#16
Marieke L M Jenniskens, Jan H W Veerbeek, Koen L Deurloo, Erik J van Hannen, Steven F T Thijsen
BACKGROUND: Mycoplasma genitalium (MG) and Trichomonas vaginalis (TV) are common sexual transmitted infections (STI). However, most STI screening programmes do not include routinely detection of these pathogens. Consequently, epidemiological data about MG and TV in the general population is lacking. The current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. METHODS: Between February 2013 and August 2015, all samples sent to the laboratory of Diakonessenhuis Utrecht for STI testing (i...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28291669/mycoplasma-genitalium-in-spain-prevalence-of-genital-infection-and-frequency-of-resistance-to-macrolides
#17
Alejandra Asenjo, Johannes G Kusters, Tim T Severs, Juan-Ignacio Alós
INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015. METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced...
March 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28268197/microbial-invasion-of-the-amniotic-cavity-in-midtrimester-pregnancies-using-molecular-microbiology
#18
Shelley Rowlands, Jennifer A Danielewski, Sepehr N Tabrizi, Susan P Walker, Suzanne M Garland
OBJECTIVE: The objective of the study was to determine the frequency of microbial invasion of the amniotic cavity in the midtrimester of pregnancy in patients undergoing amniocentesis for clinical indications. STUDY DESIGN: This was a prospective investigation of the amniotic fluid of 344 asymptomatic women recruited in midpregnancy for the presence of microbial DNA. Amniotic samples obtained at the time of amniocentesis for genetic testing on women between 15 and 22 weeks of gestation were tested specifically for the presence of Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium as well as for other bacteria and fungi using broad-range polymerase chain reaction only...
March 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28263902/mollicutes-in-vaginal-microbiology-mycoplasma-hominis-ureaplasma-urealyticum-ureaplasma-parvum-and-mycoplasma-genitalium
#19
David Taylor-Robinson
Mycoplasma hominis was isolated in 1937 from the human genital tract, followed 17 years later by Ureaplasma urealyticum and 27 years after that by Mycoplasma genitalium. The first two proved relatively easy to culture but the latter required a polymerase chain reaction assay for further studies. In sexually mature women, M. hominis may be found in the vagina/cervix of about 20-50%, ureaplasmas in 40-80% and M. genitalium in 0-5%. Some heterogeneity has been found among strains of all these species, sufficient to divide ureaplasmas into two species, namely U...
March 2, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28260146/simultaneous-detection-and-identification-of-sti-pathogens-by-multiplex-real-time-pcr-in-genital-tract-specimens-in-a-selected-area-of-apulia-a-region-of-southern-italy
#20
Raffaele Del Prete, Luigi Ronga, Mirella Lestingi, Grazia Addati, Umberto Filippo Angelotti, Domenico Di Carlo, Giuseppe Miragliotta
PURPOSE: Genital tract infections are globally a major cause of morbidity in sexually active individuals. The aim of this study was to investigate the prevalence and associations of co-infections of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis (MH), Mycoplasma genitalium, Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) in specimens collected from female (SF) and male (SM) patients. METHODS: 1575 samples from 1575 individuals from the geographical area around Bari, Apulia region in Southern Italy, were collected and analyzed by a multiplex Real-Time PCR (mRT-PCR) (Anyplex(TM) II STI-7, Seegene, Inc...
March 4, 2017: Infection
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