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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#1
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28159916/impact-of-deploying-multiple-point-of-care-tests-with-a-sample-first-approach-on-a-sexual-health-clinical-care-pathway-a-service-evaluation
#2
Emma M Harding-Esch, Achyuta V Nori, Aseel Hegazi, Marcus J Pond, Olanike Okolo, Anthony Nardone, Catherine M Lowndes, Phillip Hay, S Tariq Sadiq
OBJECTIVES: To assess clinical service value of STI point-of-care test (POCT) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). Specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (NAAT) for Chlamydia trachomatis/Neisseria gonorrhoeae (CT/NG) could be used as a POCT in practice; feasibility of non-NAAT POCT implementation for Trichomonas vaginalis (TV) and bacterial vaginosis (BV); impact on patient diagnosis and treatment...
February 3, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28158595/high-prevalence-of-the-a2058t-macrolide-resistance-associated-mutation-in-mycoplasma-genitalium-strains-from-the-netherlands
#3
Joyce F Braam, Brenda Slotboom, Sebastian Van Marm, Tim T Severs, Noortje M Van Maarseveen, Ton Van Zwet, Edwin C H Boel, Hanneke Berkhout, Ferry Hagen, Jeroen H B Van De Bovenkamp, Laura Van Dommelen, Johannes G Kusters
No abstract text is available yet for this article.
February 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28118803/meta-analysis-of-the-efficacy-of-moxifloxacin-in-treating-mycoplasma-genitalium-infection
#4
Yang Li, Wen-Jing Le, Sai Li, Yu-Ping Cao, Xiao-Hong Su
Mycoplasma genitalium is an important pathogen that is transmitted through sexual contact. For patients diagnosed with M. genitalium infection, the current guidelines recommend 1 g of azithromycin as the first-line treatment. Moxifloxacin is used as a second-line drug due to its remarkable efficacy; however, increased use of moxifloxacin to treat M. genitalium infections has caused the emergence of cases of moxifloxacin treatment failure. This meta-analysis aims to estimate the treatment efficacy of moxifloxacin for M...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28114309/superior-multiplexing-capacity-of-plexprimers-enables-sensitive-and-specific-detection-of-snps-and-clustered-mutations-in-qpcr
#5
Lit Yeen Tan, Samantha Michelle Walker, Tina Lonergan, Nicole Elizabeth Lima, Alison Velyian Todd, Elisa Mokany
BACKGROUND: Whilst qPCR provides an extremely powerful tool for genetic analysis, some applications such as multiplexing variant alleles (eg SNPs, point mutations or deletions), remain challenging using current primer/probe systems. The novel design features of PlexPrimers allow sensitive, multiplexed analysis of variant alleles even when these are tightly clustered. METHOD: PlexPrimers were combined with PlexZymes in qPCR assays for the detection of SNPs in human absorption, distribution, metabolism, and excretion (ADME) genes; clustered mutations in the 23S rRNA gene which confer antibiotic resistance to Mycoplasma genitalium; and deletions within the human epidermal growth factor receptor (EGFR) gene...
2017: PloS One
https://www.readbyqxmd.com/read/28112332/-molecular-detection-of-sexually-transmitted-agents-in-a-symptomatic-group-of-men-and-its-relationship-with-sexual-behavior
#6
Daniela León, Javier Retamal, Ramón Silva, Carmen Ili, Stephanie Mieville, Pablo Guzmán, Gastón Briceño, Priscilla Brebi
BACKGROUND: Sexually transmitted infections (STIs) affect sexual and reproductive health of millions of men. Pathogens such as human papillomavirus (HPV), herpes simplex virus type 1 and 2 (HSV-1 y HSV-2), Chlamydia trachomatis,Mycoplasmagenitalium,Mycoplasma hominis and Ureaplasma urealyticum are associated with STIs. AIM: To detect pathogens associated with STIs in symptomatic men and its relationship with sexual behavior. METHODOLOGY: DNA was obtained from exfoliated cells of penis from 20 symptomatic men...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28099135/mycoplasma-ureaplasma-infection-in-pregnancy-to-screen-or-not-to-screen
#7
Gilbert G G Donders, Kateryna Ruban, Gert Bellen, Ljubomir Petricevic
Mycoplasmata have been linked to pregnancy complications and neonatal risk. While formerly a limited number of species could be discovered by cultures, molecular biology nowadays discovers both lower quantities and more diverse species, making us realize that mycoplasmata are ubiquitous in the vaginal milieu and do not always pose a danger for pregnant women. As the meaning of mycoplasmata in pregnancy is not clear to many clinicians, we summarized the current knowledge about the meaning of different kinds of mycoplasmata in pregnancy and discuss the potential benefits and disadvantages of treatment...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28079749/should-female-partners-of-men-with-non-gonococcal-urethritis-negative-for-chlamydia-trachomatis-and-mycoplasma-genitalium-be-informed-and-treated-clinical-outcomes-from-a-partner-study-of-heterosexual-men-with-ngu
#8
Jason J Ong, Angela Sarumpaet, Eric P F Chow, Catriona Bradshaw, Marcus Chen, Tim Read, Christopher K Fairley
BACKGROUND: To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection. METHODS: Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28072403/antimicrobial-resistant-sexually-transmitted-infections-gonorrhoea-and-mycoplasma-genitalium
#9
REVIEW
Magnus Unemo, Jorgen S Jensen
The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro and clinically, to essentially all antimicrobials available for treatment, causing exceedingly difficult-to-treat or untreatable STIs and threatening global public health. Widespread AMR in these bacteria is likely to persist and even worsen in the future, owing to the high number of infections, widespread and uncontrolled use of antimicrobials, limited surveillance of AMR and clinical failures, as well as the extraordinary capacity of these bacteria to develop AMR...
January 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28032361/relationship-between-chlamydia-trachomatis-and-mycoplasma-genitalium-infection-and-pregnancy-rate-and-outcome-in-iranian-infertile-couples
#10
L Dehghan Marvast, A Aflatoonian, A R Talebi, A Eley, A A Pacey
The study was performed to investigate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in a population of infertile couples from Iran and how this relates to tubal factor infertility, pregnancy rate and outcome of pregnancy. Blood, semen and first-void urine samples were obtained from 250 infertile couples and 250 fertile women as a control. Infertile couples were followed up after 24 months to determine diagnosis, referral for assisted conception, any pregnancy and pregnancy outcome. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C...
December 29, 2016: Andrologia
https://www.readbyqxmd.com/read/28031435/evaluation-of-a-commercial-multiplex-qpcr-assay-for-simultaneous-detection-of-mycoplasma-genitalium-and-macrolide-resistance-associated-mutations-in-clinical-specimens
#11
Chloé Le Roy, Nadège Hénin, Cécile Bébéar, Sabine Pereyre
Macrolide antibiotics are the first-line treatment for Mycoplasma genitalium infections however macrolide resistance has increased up to 40% in several countries (1-3).….
December 28, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28011607/azithromycin-1-5g-over-5-days-compared-to-1g-single-dose-in-urethral-mycoplasma-genitalium-impact-on-treatment-outcome-and-resistance
#12
Tim R H Read, Christopher K Fairley, Sepehr N Tabrizi, Melanie Bissessor, Lenka Vodstrcil, Eric P F Chow, Mieken Grant, Jennifer Danielewski, Suzanne M Garland, Jane S Hocking, Marcus Y Chen, Catriona S Bradshaw
BACKGROUND: We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 and compared this to cases treated with azithromycin 1g in 2012-2013. METHODS: Microbiological cure was determined for men with M. genitalium urethritis treated with azithromycin 1.5g using quantitative polymerase chain reaction specific for M. genitalium DNA on samples 14-100 days post-treatment...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28007229/sexually-transmitted-diseases-and-infertility
#13
REVIEW
Danielle G Tsevat, Harold C Wiesenfeld, Caitlin Parks, Jeffrey F Peipert
Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27981387/-non-viral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostics-and-therapy-part%C3%A2-2-chlamydia-and-mycoplasma
#14
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
Chlamydia trachomatis is the most common pathogen of sexually transmitted bacterial infections worldwide. Every year in Germany approximately 300,000 new infections are to be expected. Chlamydia infections occur nearly exclusively in the postpubertal period. The peak age group is 15-25 years. The infection usually runs an asymptomatic course and the diagnosis is made by nucleic acid amplification techniques (NAAT) often after chlamydial screening or if complications occur. For treatment of chlamydial infections oral doxycycline 100 mg twice daily over 7 days is initially used or alternatively oral azithromycin 1...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27935945/correction-improved-metabolic-models-for-e-coli-and-mycoplasma-genitalium-from-globalfit-an-algorithm-that-simultaneously-matches-growth-and-non-growth-data-sets
#15
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1005036.].
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27898565/quantitative-real-time-polymerase-chain-reaction-for-the-diagnosis-of-mycoplasma-genitalium-infection-in-south-african-men-with-and-without-symptoms-of-urethritis
#16
Marie Cecilia le Roux, Anwar Ahmed Hoosen
BACKGROUND: This study was done to diagnose Mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. METHODS: Urine specimens from 94 men with visible urethral discharge, 206 with burning on micturition and 75 without symptoms presenting to a family practitioner were tested for M. genitalium as well as Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis by transcription-mediated amplification assays...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27894204/clinical-laboratory-assessments-for-mycoplasma-genitalium-in-a-high-prevalence-sexually-transmitted-infection-community-reveal-epidemiologic-dichotomies-with-trichomonas-vaginalis
#17
Erik Munson, Kimber L Munson, Ronald F Schell
Mycoplasma genitalium is an emerging agent of sexually-transmitted infection and is responsible for clinically-significant genital tract disease in both females and males. Similar to scenarios recently experienced with the urogenital flagellate Trichomonas vaginalis, an evolving molecular diagnostic reference standard based on transcription-mediated amplification allows for accurate detection of the organism, plus additional insight into disease epidemiology. Areas covered. The basis for this article includes primary peer-reviewed literature plus compilations of data derived from routine clinical laboratory screening of females and males for agents of sexually-transmitted infection...
December 10, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27893600/prevalence-and-correlates-of-genital-infections-among-newly-diagnosed-human-immunodeficiency-virus-infected-adults-entering-human-immunodeficiency-virus-care-in-windhoek-namibia
#18
Gaston Djomand, Madeleine Schlefer, Steve Gutreuter, Sarah Tobias, Roopal Patel, Nickolas DeLuca, Julia Hood, Souleymane Sawadogo, Cheng Chen, Alexinah Muadinohamba, David W Lowrance, Naomi Bock
BACKGROUND: Identifying and treating genital infections, including sexually transmitted infections (STI), among newly diagnosed human immunodeficiency virus (HIV)-infected individuals may benefit both public and individual health. We assessed prevalence of genital infections and their correlates among newly diagnosed HIV-infected individuals enrolling in HIV care services in Namibia. METHODS: Newly diagnosed HIV-infected adults entering HIV care at 2 health facilities in Windhoek, Namibia, were recruited from December 2012 to March 2014...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27882384/prevalence-of-mycoplasma-genitalium-infection-and-relationship-with-symptoms-among-adults-attending-a-sexual-health-centre
#19
Maeva Lefebvre, Julie Coutherut, Sophie Gibaud, Charlotte Biron, Marine Chalopin, Claire Bernier, François Raffi
is missing (Short communication).
November 24, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27872239/experimental-infection-of-pig-tailed-macaques-macaca-nemestrina-with-mycoplasma-genitalium
#20
Gwendolyn E Wood, Dorothy L Patton, Peter K Cummings, Stefanie L Iverson-Cabral, Patricia A Totten
Mycoplasma genitalium is an underappreciated cause of human reproductive tract disease, characterized by persistent, often asymptomatic, infection. Building on our previous experiments using a single female pig-tailed macaque as a model for M. genitalium infection (G. E. Wood, S. L. Iverson-Cabral, D. L. Patton, P. K. Cummings, Y. T. Cosgrove Sweeney, and P. A. Totten, Infect Immun 81:2938-2951, 2013, https://doi.org/10.1128/IAI.01322-12), we cervically inoculated eight additional animals, two of which were simultaneously inoculated in salpingeal tissue autotransplanted into abdominal pockets...
February 2017: Infection and Immunity
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