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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/29028993/high-prevalence-of-multidrug-resistant-mycoplasma-genitalium-in-hiv-infected-men-who-have-sex-with-men-in-alabama
#1
J Dionne-Odom, W M Geisler, K J Aaron, K B Waites, A O Westfall, B Van Der Pol, L Xiao
We tested for Mycoplasma genitalium in 157 HIV-infected men in Alabama who were mostly asymptomatic. Urogenital and rectal prevalence were 10.8% and 6.4%, respectively. Macrolide resistance mutations were detected in 70.6% and 80% of urogenital and rectal samples and fluoroquinolone resistance mutations in 26.7% and 40% of samples, respectively.
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020330/enhanced-sexually-transmitted-infection-screening-for-mycoplasma-genitalium-in-human-immunodeficiency-virus-infected-us-air-force-personnel
#2
Shilpa Hakre, Rosemary O Casimier, Brooke A Danboise, Sheila A Peel, Nelson L Michael, Paul T Scott, Jason F Okulicz
Three-site genital and extragenital screening for Mycoplasma genitalium in 102 asymptomatic Air Force members with human immunodeficiency virus (HIV) infection revealed 19 (18.6%) cases of M. genitalium, commonly (58%) in rectal samples. Because M. genitalium is associated with both HIV acquisition and transmission, these findings suggest that it should be included in routine screening of HIV-infected individuals for sexually transmitted infections.
August 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28988903/macrolide-resistance-in-mycoplasma-genitalium-in-female-sex-workers-belgium
#3
Liselotte Coorevits, Ans Traen, Luk Bingé, Patrick Descheemaeker, Jerina Boelens, Marijke Reynders, Elizaveta Padalko
OBJECTIVES: Mycoplasma genitalium is emerging as an etiological agent of sexually transmitted infections. Though M. genitalium is commonly treated with azithromycin, macrolide resistance associated with point mutations in the 23S rRNA gene is emerging. METHODS: We evaluated the prevalence of (macrolide-resistant) M. genitalium in female sex workers in Belgium, by means of a prospective study conducted between 2015 and 2016. Vaginal swabs were sampled from 303 participants who underwent testing for M...
October 5, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28979150/mycoplasma-genitalium-infections-current-treatment-options-and-resistance-issues
#4
REVIEW
Sunil Sethi, Kamran Zaman, Neha Jain
Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen over a period of time was changed to extended regimen following studies showing better clinical cures and less risk of resistance development. However, emerging macrolide resistance, either due to transmission of resistance or drug pressure has further worsened the management of this infection...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28960028/prevalence-of-and-risk-factors-for-sexually-transmitted-infections-among-korean-adolescents-under-probation
#5
Jin Ju Park, Yu Bin Seo, Sookyung Jeong, Jacob Lee
There is limited research on sexually transmitted infections (STIs) among adolescents in Korea. The objective of this study was to explore the prevalence of and risk factors for STIs among Korean adolescents under probation. A cross-sectional analysis was conducted in one juvenile-delinquent center and five probation offices in Korea to determine the prevalence of STIs caused by the following pathogens: Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, herpes simplex virus (HSV), human immunodeficiency virus (HIV), Treponema pallidum, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, and Ureaplasma parvum...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28927691/comparative-genomics-of-four-mycoplasma-species-of-the-human-urogenital-tract-analysis-of-their-core-genomes-and-virulence-genes
#6
Orville St E Roachford, Karen E Nelson, Bidyut R Mohapatra
The variation in Mycoplasma lipoproteins attributed to genome rearrangements and genetic insertions leads to phenotypic plasticity that allows for the evasion of the host's defence system and pathogenesis. This paper compared for the first time the genomes of four human urogenital Mycoplasma species (M. penetrans HF-2, M. fermentans JER, M. genitalium G37 and M. hominis PG21) to categorise the metabolic functions of the core genes and to assess the effects of tandem repeats, phage-like genetic elements and prophages on the virulence genes...
September 5, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-genitalium-prevalence-and-antimicrobial-resistance-in-m-genitalium-in-denmark-norway-and-sweden-in-2016
#7
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Steczkó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new CE/IVD Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 15, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28893363/high-levels-of-macrolide-resistant-mycoplasma-genitalium-in-queensland-australia
#8
Ella Trembizki, Cameron Buckley, Cheryl Bletchly, Graeme R Nimmo, David M Whiley
The macrolide azithromycin is recommended for treatment of Mycoplasma genitalium infection; however, M. genitalium strains possessing macrolide resistance-mediating mutations (MRMMs) are increasingly being reported. Here, we used the SpeeDx ResistancePlus MG kit, which provides simultaneous detection of M. genitalium and MRMMs, to assess MRMM carriage among M. genitalium infections in Queensland, Australia. Performance characteristics of the ResistancePlus MG kit for M. genitalium detection were compared to in-house PCR...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28882163/prevalence-and-significance-of-mycoplasma-genitalium-in-women-living-with-hiv-in-denmark
#9
Anne Marie Rosendahl Madsen, Kristina Thorsteinsson, Anne-Mette Lebech, Merete Storgaard, Terese L Katzenstein, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Noerregaard Nielsen, Aase Bengaard Andersen, Jørgen Skov Jensen
OBJECTIVE: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. genitalium and HIV infection, therefore screening and treatment for M. genitalium has been suggested as part of HIV prevention strategies. The objective of this study was to determine the prevalence of M. genitalium in women living with HIV (WLWH) in Denmark, and to compare the result with data on symptoms from the lower abdomen, sexual habits and immune status...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28878004/mycoplasma-genitalium-macrolide-and-fluoroquinolone-resistance-detection-and-clinical-implications-in-a-selected-cohort-in-new-zealand
#10
Trevor Anderson, Edward Coughlan, Anja Werno
Mycoplasma genitalium has been associated with infections of the genitourinary tract and prevalence is secondary to Chlamydia trachomatis The clinical observation of increasing treatment failure indicating antibiotic resistance, especially in cases of recurrent urethritis, has been confirmed by molecular testing. Mutations in the 23S rRNA gene can cause macrolide resistance and topoisomerase/gyrase mutations can cause fluoroquinolone resistance. In this study, 115 M. genitalium DNA positive samples were analysed...
September 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28868962/prevalence-of-mycoplasma-genitalium-and-other-sexually-transmitted-infections-causing-urethritis-among-high-risk-heterosexual-male-patients-in-estonia
#11
Stanislav Tjagur, Reet Mändar, Margus Punab
BACKGROUND: We aimed to evaluate the prevalence of sexually transmitted infections (STI, including Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis) among high-risk heterosexual male patients and to clarify their potency to cause complaints and inflammation. METHODS: The study group included 825 men (18.0-49.5 y) consulting andrologist at Tartu University Hospital (Estonia) due to subjectively perceived risk of STI. Patients completed STI risk behaviour questionnaire...
September 4, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28838079/developing-a-public-health-response-to-mycoplasma-genitalium
#12
REVIEW
Matthew R Golden, Kimberly A Workowski, Gail Bolan
Although Mycoplasma genitalium is increasingly recognized as a sexually transmitted pathogen, at present there is no defined public health response to this relatively newly identified sexually transmitted infection. Currently available data are insufficient to justify routinely screening any defined population for M. genitalium infection. More effective therapies, data on acceptability of screening and its impact on clinical outcomes, and better information on the natural history of infection will likely be required before the value of potential screening programs can be adequately assessed...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838078/mycoplasma-genitalium-in-women-current-knowledge-and-research-priorities-for-this-recently-emerged-pathogen
#13
REVIEW
Harold C Wiesenfeld, Lisa E Manhart
Health consequences of sexually transmitted diseases disproportionately affect women, making it important to determine whether newly emerged pathogens cause sequelae. Although the pathogenic role of Mycoplasma genitalium in male urethritis is clear, fewer studies have been conducted among women to determine its pathogenic role in the female reproductive tract. Pelvic inflammatory disease (PID) is an important cause of infertility and ectopic pregnancy, and Chlamydia trachomatis and Neisseria gonorrhoeae are recognized microbial causes...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838077/the-unique-microbiology-and-molecular-pathogenesis-of-mycoplasma-genitalium
#14
REVIEW
Chris L McGowin, Patricia A Totten
Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women. Despite these disease associations, which parallel those of Chlamydia trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular damage, and persists in its only natural host (humans) are unique and are not fully understood...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838076/mycoplasma-genitalium-from-basic-science-to-public-health-implications-results-of-a-national-institute-of-allergy-and-infectious-diseases-technical-consultation
#15
David H Martin
No abstract text is available yet for this article.
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838075/mycoplasma-genitalium-from-basic-science-to-public-health-summary-of-the-results-from-a-national-institute-of-allergy-and-infectious-disesases-technical-consultation-and-consensus-recommendations-for-future-research-priorities
#16
REVIEW
David H Martin, Lisa E Manhart, Kimberly A Workowski
This article lays out the research priorities for Mycoplasma genitalium research agreed upon by the participants in a 2016 National Institutes of Allergy and Infectious Diseases-funded Technical Consultation focused on this organism. The state of current knowledge concerning the microbiology, epidemiology, clinical manifestations of infection, treatment, and public health significance of M. genitalium reviewed at the meeting is described in detail in the individual articles included in this supplemental edition of the Journal of Infectious Diseases...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838074/mycoplasma-genitalium-infection-in-men
#17
REVIEW
Patrick J Horner, David H Martin
Mycoplasmagenitalium is one of the major causes of nongonococcal urethritis (NGU) worldwide but an uncommon sexually transmitted infection (STI) in the general population. The risk of sexual transmission is probably lower than for Chlamydia trachomatis. Infection in men is usually asymptomatic and it is likely that most men resolve infection without developing disease. The incubation period for NGU caused by Mycoplasma genitalium is probably longer than for NGU caused by C. trachomatis. The clinical characteristics of symptomatic NGU have not been shown to identify the pathogen specific etiology...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838073/new-horizons-in-mycoplasma-genitalium-treatment
#18
REVIEW
Catriona S Bradshaw, Jorgen S Jensen, Ken B Waites
Mycoplasmagenitalium is an important sexually transmitted pathogen responsible for both male and female genital tract disease. Appreciation of its significance in human disease has been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molecular-based tests for rapid detection. Comparatively few in vitro data on antimicrobial susceptibility are available due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determine minimum inhibitory concentrations for M...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838072/mycoplasma-genitalium-accurate-diagnosis-is-necessary-for-adequate-treatment
#19
REVIEW
Charlotte A Gaydos
Background: Mycoplasma genitalium is very difficult to grow in culture but has been more able to be studied for disease associations since the advent of research molecular amplification assays. Polymerase chain reaction (PCR) and other molecular assays have demonstrated an association with adverse disease outcomes, such as urethritis or nongonococcal urethritis in men and adverse reproductive sequelae in women-for example, cervicitis, endometritis, and pelvic inflammatory disease (PID), including an association with risk for human immunodeficiency virus...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28803864/the-detection-of-microorganisms-related-to-urethritis-from-the-oral-cavity-of-male-patients-with-urethritis
#20
Phuong Thi Le, Ryoichi Hamasuna, Masahiro Matsumoto, Keiichi Furubayashi, Masayuki Hatanaka, Shuichi Kawai, Takamasa Yamaguchi, Kazutaka Uehara, Norihiko Murakami, Masaru Yoshioka, Ken Nakayama, Yutaka Shiono, Keisuke Muraoka, Masahiko Suzuki, Naohiro Fujimoto, Tetsuro Matsumoto
OBJECTIVES: To investigate the presence of microorganisms related to urethritis in the oral cavity of male patients with urethritis and the efficacies of antimicrobials for urethritis on microorganisms in the oral cavity. METHODS: Ninety-two male patients with urethritis and 17 male controls participated to this study at 12 urology clinics in Japan between March 2014 and March 2015. The first voided urine (FVU) and oral wash fluid (OWF) specimens were collected from the participants...
October 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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