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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/29444242/in-vitro-activity-of-zoliflodacin-etx0914-against-macrolide-resistant-fluoroquinolone-resistant-and-antimicrobial-susceptible-mycoplasma-genitalium-strains
#1
A C Damião Gouveia, M Unemo, J S Jensen
Background: Mycoplasma genitalium is estimated to be the second most common cause of bacterial sexually transmitted infection in Europe. It is of increasing public health concern due to the rapid development of resistance to different antimicrobial classes, including the preferred first- and second-line treatments azithromycin and moxifloxacin. Thus, new antimicrobial agents are urgently needed, especially for the treatment of MDR strains. Methods: The in vitro activity of the new spiropyrimidinetrione zoliflodacin against 47 M...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29431025/highlighting-the-clinical-need-for-diagnosing-mycoplasma-genitalium-infection
#2
Catherine A Ison, Helen Fifer, Simon Gwynn, Paddy Horner, Peter Muir, Jane Nicholls, Keith Radcliffe, Jonathan Ross, David Taylor-Robinson, John White
Despite Mycoplasma genitalium (MG) being increasingly recognised as a genital pathogen in men and women, awareness and utility of commercially available MG-testing has been low. The opinion of UK sexual health clinicians and allied professionals was sought on how MG-testing should be used. Thirty-two consensus statements were developed by an expert group and circulated to clinicians and laboratory staff, who were asked to evaluate their level of agreement with each statement; 75% agreement was set as the threshold for defining consensus for each statement...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29428309/mycoplasma-genitalium-can-modulate-the-local-immune-response-in-patients-with-endometriosis
#3
Guilherme B Campos, Lucas M Marques, Izadora S Rezende, Maysa S Barbosa, Mauricio S Abrão, Jorge Timenetsky
OBJECTIVE: To detect Mollicutes in women with endometriosis and healthy peritoneal tissues and evaluate the participation of these bacteria in the immune response during endometriosis. DESIGN: Cross-sectional study. SETTING: University hospitals. PATIENT (S): Women with endometriosis (n = 73) and without endometriosis (n = 31). INTERVENTION(S): Endocervical swabs, peritoneal fluid, and biopsied lesions of endometriosis of women with endometriosis (study group) and healthy peritoneal tissues (control group) were collected during surgery...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29393016/analysis-of-the-mycoplasma-bovis-lactate-dehydrogenase-reveals-typical-enzymatic-activity-despite-the-presence-of-an-atypical-catalytic-site-motif
#4
Yumiko Masukagami, Kelly Anne Tivendale, Glenn Francis Browning, Fiona Margaret Sansom
The lactate dehydrogenase (LDH) of Mycoplasma genitalium has been predicted to also act as a malate dehydrogenase (MDH), but there has been no experimental validation of this hypothesized dual function for any mollicute. Our analysis of the metabolite profile of Mycoplasma bovis using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) detected malate, suggesting that there may be MDH activity in M. bovis. To investigate whether the putative l-LDH enzyme of M. bovis has a dual function (MDH and LDH), we performed bioinformatic and functional biochemical analyses...
February 2018: Microbiology
https://www.readbyqxmd.com/read/29387826/the-prevalence-of-and-risk-factors-for-mycoplasma-genitalium-infection-among-infertile-women-in-ibadan-a-cross-sectional-study
#5
Tinuade Adesola Ajani, Timothy A Olusesan Oluwasola, Mustapha A Ajani, Rasheed Ajani Bakare
Background: The association of mycoplasma genitalium (M. genitalium) with infertility has been documented. The infections are asymptomatic and difficult to diagnose. Understanding the associated risk factors will help in facilitating better screening measures for at-risk groups. Objective: The aim was to determine the prevalence of, and risk factors for, M. genitalium infection among infertile women in Ibadan. Materials and Methods: In this cross-sectional study, 402 women (267 infertile and 135 fertile) referred to 2 hospitals in Ibadan between March and November 2015 were enrolled...
October 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29376018/effects-of-infections-with-five-sexually-transmitted-pathogens-on-sperm-quality
#6
Sung Jae Kim, Doo-Jin Paik, Joong Shik Lee, Hyo Serk Lee, Ju Tae Seo, Mi Seon Jeong, Jae-Ho Lee, Dong Wook Park, Sangchul Han, Yoo Kyung Lee, Ki Heon Lee, In Ho Lee, Kyeong A So, Seon Ah Kim, Juree Kim, Tae Jin Kim
Objective: This study investigated the prevalence of infections with human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and Mycoplasma genitalium in the semen of Korean infertile couples and their associations with sperm quality. Methods: Semen specimens were collected from 400 men who underwent a fertility evaluation. Infection with above five pathogens was assessed in each specimen. Sperm quality was compared in the pathogen-infected group and the non-infected group...
December 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29369931/identifying-acute-cervicitis-in-an-era-of-less-frequent-routine-gynecologic-examinations
#7
Margaret Allen
Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated...
February 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29358335/mycoplasma-genitalium-non-adherent-phase-variants-arise-by-multiple-mechanisms-and-escape-antibody-dependent-growth-inhibition
#8
Raul Burgos, Gwendolyn E Wood, Stefanie Iverson-Cabral, Patricia A Totten
Antigenic variation of the immunodominant MgpB and MgpC proteins has been suggested as a mechanism of immune evasion of the human pathogen Mycoplasma genitalium, a cause of several reproductive tract disease syndromes. Phase variation resulting in the loss of adherence has also been documented, but the molecular mechanisms underlying this process and its role in pathogenesis are still poorly understood. In this study we isolated and characterized 40 spontaneous, non-adherent phase variants from in vitro-passaged M...
January 22, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29350154/use-of-pristinamycin-for-macrolide-resistant-mycoplasma-genitalium-infection
#9
Tim R H Read, Jørgen S Jensen, Christopher K Fairley, Mieken Grant, Jennifer A Danielewski, Jenny Su, Gerald L Murray, Eric P F Chow, Karen Worthington, Suzanne M Garland, Sepehr N Tabrizi, Catriona S Bradshaw
High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Microbiologic cure was determined by M. genitalium-specific 16S PCR 14-90 days after treatment began. Of 114 persons treated with pristinamycin, infection was cured in 85 (75%). This percentage did not change when pristinamycin was given at daily doses of 2 g or 4 g or at 3 g combined with 200 mg doxycycline...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29342269/a-silent-epidemic-the-prevalence-incidence-and-persistence-of-mycoplasma-genitalium-among-young-asymptomatic-high-risk-women-in-the-united-states
#10
Arlene C Seña, Jeannette Y Lee, Jane Schwebke, Susan S Philip, Harold C Wiesenfeld, Anne M Rompalo, Robert L Cook, Marcia M Hobbs
Background: Mycoplasma genitalium (MG) is a sexually transmitted infection (STI) that can result in pelvic inflammatory disease and adverse pregnancy outcomes. We analyzed data collected from a prospective study of asymptomatic bacterial vaginosis (BV) to determine the natural history of MG. Methods: Women aged 15-25 years, with ≥2 STI risk factors and asymptomatic BV were recruited from 10 sites throughout the United States. Vaginal swabs were collected at enrollment, and by home-based testing every 2 months over 12 months...
January 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29338247/lattice-models-of-bacterial-nucleoids
#11
David S Goodsell, Ludovic Autin, Arthur J Olson
Mesoscale molecular modeling is providing a new window on the inner workings of living cells. Modeling of genomes, however, remains a technical challenge, due to their large size and complexity. We describe a lattice method for rapid generation of bacterial nucleoid models that integrates experimental data from a variety of biophysical techniques and provides a starting point for simulation and hypothesis generation. The current method builds models of a circular bacterial genome with supercoiled plectonemes, packed within the small space of the bacterial cell...
January 16, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29281972/mycoplasma-genitalium-whole-genome-sequence-analysis-recombination-and-population-structure
#12
Maria C Fookes, James Hadfield, Simon Harris, Surendra Parmar, Magnus Unemo, Jørgen S Jensen, Nicholas R Thomson
BACKGROUND: Although Mycoplasma genitalium is a common sexually transmitted pathogen causing clinically distinct diseases both in male and females, few genomes have been sequenced up to now, due mainly to its fastidious nature and slow growth. Hence, we lack a robust phylogenetic framework to provide insights into the population structure of the species. Currently our understanding of the nature and diversity of M. genitalium relies on molecular tests targeting specific genes or regions of the genome and knowledge is limited by a general under-testing internationally...
December 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29262291/diagnosis-of-chlamydia-trachomatis-neisseria-gonorrhoeae-trichomonas-vaginalis-and-mycoplasma-genitalium-an-observational-study-of-testing-patterns-prevalence-and-co-infection-rates-in-northern-new-zealand
#13
Arlo Upton, Liselle Bissessor, Peter Lowe, Xiaoying Wang, Gary McAuliffe
Background: This study sought to determine community prevalence, epidemiology and testing patterns for sexually transmissible infections (STI) in northern New Zealand. Methods: A total of 2643 samples submitted for STI testing between 26 November 2015 and 7 December 2015 underwent analysis by Aptima Combo 2 (Hologic, San Diego, CA, USA), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) assays. Results were analysed by patient demographics. Results: Four hundred and eleven pathogens were detected from 359 patients, with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), TV, and MG detected in 178 (6...
December 21, 2017: Sexual Health
https://www.readbyqxmd.com/read/29240635/the-etiology-of-male-urethral-discharge-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#14
Cornelis A Rietmeijer, More Mungati, Anna Machiha, Owen Mugurungi, Vitalis Kupara, Luanne Rodgers, Peter H Kilmarx, Amy Herman Roloff, Elizabeth Gonese, Beth A Tippett-Barr, Gerald Shambira, David A Lewis, H Hunter Handsfield, Mufuta Tshimanga
INTRODUCTION: Sexually transmitted infections (STIs) are managed syndromically in most developing countries. In Zimbabwe, men presenting with urethral discharge are treated with a single intramuscular dose of kanamycin or ceftriaxone in combination with a week's course of oral doxycycline. This study was designed to assess the current etiology of urethral discharge and other STIs to inform current syndromic management regimens. METHODS: We conducted a study among 200 men with urethral discharge presenting at 6 regionally diverse STI clinics in Zimbabwe...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29235145/macrolide-and-fluoroquinolone-resistance-in-mycoplasma-genitalium-in-two-swedish-counties-2011-2015
#15
Ronza Hadad, Daniel Golparian, Amaya C Lagos, Johan Ljungberg, Peter Nilsson, Jörgen S Jensen, Hans Fredlund, Magnus Unemo
Mycoplasma genitalium, causing non-gonococcal non-chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first-line treatment) and the fluoroquinolone moxifloxacin (second-line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011-2015. In total, 672 M. genitalium positive urogenital samples were sequenced for 23S rRNA and parC gene mutations associated with macrolide and fluoroquinolone resistance, respectively...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29198181/2017-european-guideline-for-the-management-of-pelvic-inflammatory-disease
#16
Jonathan Ross, Secondo Guaschino, Marco Cusini, Jorgen Jensen
The European guideline for the management of pelvic inflammatory disease includes evidence-based advice on the investigation and treatment of pelvic inflammatory disease (PID). It has been updated to acknowledge the role of Mycoplasma genitalium as an important cause of PID with testing now recommended for women presenting with possible PID and for the male partners of women with confirmed M. genitalium infection. Recent evidence suggests that serious adverse events are uncommon when using moxifloxacin and its use is now recommended as a first-line therapy, especially in those women with M...
February 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29198180/converging-epidemics-of-sexually-transmitted-infections-and-bacterial-vaginosis-in-southern-african-female-adolescents-at-risk-of-hiv
#17
Shaun L Barnabas, Smritee Dabee, Jo-Ann S Passmore, Heather B Jaspan, David A Lewis, Shameem Z Jaumdally, Hoyam Gamieldien, Lindi Masson, Etienne Muller, Venessa D Maseko, Nonhlanhla Mkhize, Zizipho Mbulawa, Anna-Lise Williamson, Clive M Gray, Thomas J Hope, Francesca Chiodi, Janan Dietrich, Glenda Gray, Linda-Gail Bekker
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years) from two South African communities (Soweto and Cape Town). STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) by Roche Linear Array, and BV by Nugent scoring...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29182717/doxycycline-in-the-management-of-sexually-transmitted-infections
#18
Hélène Peyriere, Alain Makinson, Hélène Marchandin, Jacques Reynes
Doxycycline is a second-generation tetracycline, available worldwide for half a century. It is an inexpensive broad-spectrum antimicrobial agent largely used in the management of several bacterial infections, particularly involving intracellular pathogens, as well as in the treatment of acne or for the prophylaxis of malaria. Physicochemical characteristics of doxycycline (liposolubility) allow a high diffusion in the tissues and organs. It has high bioavailability and a long elimination half-life allowing oral administration of one or two daily doses...
November 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29170443/should-we-screen-for-the-sexually-transmitted-infection-mycoplasma-genitalium-evidence-synthesis-using-a-transmission-dynamic-model
#19
Ruthie Birger, John Saunders, Claudia Estcourt, Andrew John Sutton, Catherine H Mercer, Tracy Roberts, Peter J White
There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. genitalium's natural history is poorly-understood, making screening's effectiveness unclear. We used a transmission-dynamic compartmental model to synthesise evidence from surveillance data and epidemiological and behavioural studies to better understand M...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29124647/improvement-of-semen-parameters-after-antibiotic-therapy-in-asymptomatic-infertile-men-infected-with-mycoplasma-genitalium
#20
Mohammad Hossein Ahmadi, Akbar Mirsalehian, Mohammad Ali Sadighi Gilani, Abbas Bahador, Malihe Talebi
OBJECTIVES: To elucidate the association between asymptomatic infections caused by Mycoplasma genitalium and male infertility, and evaluate the role of antibiotic therapy in treatment of this failure. METHODS: A total of 165 infertile males having abnormal semen parameters (study group) and 165 healthy fertile men (control group) were included. Semen samples were taken from all participants and after analyzing for semen parameters, undergone real-time PCR, microbial culture, and reactive oxygen species (ROS), as well as total antioxidant capacity (TAC) assays...
November 9, 2017: Infection
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