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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/29198181/2017-european-guideline-for-the-management-of-pelvic-inflammatory-disease
#1
Jonathan Ross, Secondo Guaschino, Marco Cusini, Jorgen Jensen
The European guideline for the management of pelvic inflammatory disease includes evidence-based advice on the investigation and treatment of pelvic inflammatory disease (PID). It has been updated to acknowledge the role of Mycoplasma genitalium as an important cause of PID with testing now recommended for women presenting with possible PID and for the male partners of women with confirmed M. genitalium infection. Recent evidence suggests that serious adverse events are uncommon when using moxifloxacin and its use is now recommended as a first-line therapy, especially in those women with M...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29198180/converging-epidemics-of-sexually-transmitted-infections-and-bacterial-vaginosis-in-southern-african-female-adolescents-at-risk-of-hiv
#2
Shaun L Barnabas, Smritee Dabee, Jo-Ann S Passmore, Heather B Jaspan, David A Lewis, Shameem Z Jaumdally, Hoyam Gamieldien, Lindi Masson, Etienne Muller, Venessa D Maseko, Nonhlanhla Mkhize, Zizipho Mbulawa, Anna-Lise Williamson, Clive M Gray, Thomas J Hope, Francesca Chiodi, Janan Dietrich, Glenda Gray, Linda-Gail Bekker
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years) from two South African communities (Soweto and Cape Town). STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) by Roche Linear Array, and BV by Nugent scoring...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29182717/doxycycline-in-the-management-of-sexually-transmitted-infections
#3
Hélène Peyriere, Alain Makinson, Hélène Marchandin, Jacques Reynes
Doxycycline is a second-generation tetracycline, available worldwide for half a century. It is an inexpensive broad-spectrum antimicrobial agent largely used in the management of several bacterial infections, particularly involving intracellular pathogens, as well as in the treatment of acne or for the prophylaxis of malaria. Physicochemical characteristics of doxycycline (liposolubility) allow a high diffusion in the tissues and organs. It has high bioavailability and a long elimination half-life allowing oral administration of one or two daily doses...
November 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29170443/should-we-screen-for-the-sexually-transmitted-infection-mycoplasma-genitalium-evidence-synthesis-using-a-transmission-dynamic-model
#4
Ruthie Birger, John Saunders, Claudia Estcourt, Andrew John Sutton, Catherine H Mercer, Tracy Roberts, Peter J White
There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. genitalium's natural history is poorly-understood, making screening's effectiveness unclear. We used a transmission-dynamic compartmental model to synthesise evidence from surveillance data and epidemiological and behavioural studies to better understand M...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29124647/improvement-of-semen-parameters-after-antibiotic-therapy-in-asymptomatic-infertile-men-infected-with-mycoplasma-genitalium
#5
Mohammad Hossein Ahmadi, Akbar Mirsalehian, Mohammad Ali Sadighi Gilani, Abbas Bahador, Malihe Talebi
OBJECTIVES: To elucidate the association between asymptomatic infections caused by Mycoplasma genitalium and male infertility, and evaluate the role of antibiotic therapy in treatment of this failure. METHODS: A total of 165 infertile males having abnormal semen parameters (study group) and 165 healthy fertile men (control group) were included. Semen samples were taken from all participants and after analyzing for semen parameters, undergone real-time PCR, microbial culture, and reactive oxygen species (ROS), as well as total antioxidant capacity (TAC) assays...
November 9, 2017: Infection
https://www.readbyqxmd.com/read/29101246/evaluation-of-the-mycoplasma-genitalium-resistance-plus-kit-for-the-detection-of-m-genitalium-and-mutations-associated-with-macrolide-resistance
#6
Rachel Pitt, Michelle Jayne Cole, Helen Fifer, Neil Woodford
OBJECTIVES: To compare performance of the ResistancePlus kit (SpeeDx, Australia) with in-house methods for the detection of Mycoplasma genitalium-specific DNA and mutations associated with resistance to macrolide antimicrobials, directly from clinical specimens. METHODS: Assay specificity and sensitivity was analysed using DNA from 46 non-M. genitalium organisms and standard curve analysis, respectively. A panel of archived DNA extracted from 97 M. genitalium-positive clinical specimens, for which the macrolide susceptibility genotype had been previously determined, were tested on the assay and results compared...
November 3, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29093102/evaluation-of-the-speedx-resistanceplus%C3%A2-mg-diagnostic-test-for-mycoplasma-genitalium-on-the-applied-biosystems-7500-fast-quantitative-pcr-platform
#7
Jenny Su, Lit Y Tan, Suzanne M Garland, Sepehr N Tabrizi, Elisa Mokany, Samantha Walker, Catriona S Bradshaw, Tim Read, Gerald L Murray
Mycoplasma genitalium is a sexually transmitted bacterium that causes urethritis in men and is associated with potentially serious sequelae in women (1).….
November 1, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29078032/synthetic-genomes
#8
Shi Chen, Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng
Rapid technological advances enabling the construction of designer gene networks, biosynthetic pathways, and even entire genomes are moving the fields of genetics and genomics from descriptive to synthetic applications. Following the synthesis of small viral genomes, advances in DNA assembly and rewriting have enabled the hierarchical synthesis of bacterial genomes, such as Mycoplasma genitalium, as well as the recoding of the Escherichia coli genome by reducing the number of codons from 64 to 57. The field has advanced to the point of synthesizing an entire eukaryotic genome...
October 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29047422/mycoplasma-genitalium-infection-in-adults-reporting-sexual-contact-with-infected-partners-australia-2008-2016
#9
Josephine B Slifirski, Lenka A Vodstrcil, Christopher K Fairley, Jason J Ong, Eric P F Chow, Marcus Y Chen, Timothy R H Read, Catriona S Bradshaw
Data on the likelihood of Mycoplasma genitalium infection in sexual contacts, particularly for men who have sex with men (MSM), are needed to form an evidence base for guidelines. We conducted a cross-sectional analysis of patients attending a sexual health clinic in Melbourne, Victoria, Australia, during 2008-2016. We calculated the proportion of contacts with M. genitalium infection and determined factors associated with infection. Among those patients reporting sexual contact with an M. genitalium-infected person, 48...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29028993/high-prevalence-of-multidrug-resistant-mycoplasma-genitalium-in-hiv-infected-men-who-have-sex-with-men-in-alabama
#10
J Dionne-Odom, W M Geisler, K J Aaron, K B Waites, A O Westfall, B Van Der Pol, L Xiao
We tested for Mycoplasma genitalium in 157 HIV-infected men in Alabama who were mostly asymptomatic. Urogenital and rectal prevalence were 10.8% and 6.4%, respectively. Macrolide resistance mutations were detected in 70.6% and 80% of urogenital and rectal samples and fluoroquinolone resistance mutations in 26.7% and 40% of samples, respectively.
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020330/enhanced-sexually-transmitted-infection-screening-for-mycoplasma-genitalium-in-human-immunodeficiency-virus-infected-us-air-force-personnel
#11
Shilpa Hakre, Rosemary O Casimier, Brooke A Danboise, Sheila A Peel, Nelson L Michael, Paul T Scott, Jason F Okulicz
Three-site genital and extragenital screening for Mycoplasma genitalium in 102 asymptomatic Air Force members with human immunodeficiency virus (HIV) infection revealed 19 (18.6%) cases of M. genitalium, commonly (58%) in rectal samples. Because M. genitalium is associated with both HIV acquisition and transmission, these findings suggest that it should be included in routine screening of HIV-infected individuals for sexually transmitted infections.
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28988903/macrolide-resistance-in-mycoplasma-genitalium-in-female-sex-workers-belgium
#12
Liselotte Coorevits, Ans Traen, Luk Bingé, Patrick Descheemaeker, Jerina Boelens, Marijke Reynders, Elizaveta Padalko
OBJECTIVES: Mycoplasma genitalium is emerging as an etiological agent of sexually transmitted infections. Though M. genitalium is commonly treated with azithromycin, macrolide resistance associated with point mutations in the 23S rRNA gene is emerging. METHODS: We evaluated the prevalence of (macrolide-resistant) M. genitalium in female sex workers in Belgium, by means of a prospective study conducted between 2015 and 2016. Vaginal swabs were sampled from 303 participants who underwent testing for M...
October 5, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28979150/mycoplasma-genitalium-infections-current-treatment-options-and-resistance-issues
#13
REVIEW
Sunil Sethi, Kamran Zaman, Neha Jain
Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen over a period of time was changed to extended regimen following studies showing better clinical cures and less risk of resistance development. However, emerging macrolide resistance, either due to transmission of resistance or drug pressure has further worsened the management of this infection...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28960028/prevalence-of-and-risk-factors-for-sexually-transmitted-infections-among-korean-adolescents-under-probation
#14
Jin Ju Park, Yu Bin Seo, Sookyung Jeong, Jacob Lee
There is limited research on sexually transmitted infections (STIs) among adolescents in Korea. The objective of this study was to explore the prevalence of and risk factors for STIs among Korean adolescents under probation. A cross-sectional analysis was conducted in one juvenile-delinquent center and five probation offices in Korea to determine the prevalence of STIs caused by the following pathogens: Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, herpes simplex virus (HSV), human immunodeficiency virus (HIV), Treponema pallidum, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, and Ureaplasma parvum...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28927691/comparative-genomics-of-four-mycoplasma-species-of-the-human-urogenital-tract-analysis-of-their-core-genomes-and-virulence-genes
#15
Orville St E Roachford, Karen E Nelson, Bidyut R Mohapatra
The variation in Mycoplasma lipoproteins attributed to genome rearrangements and genetic insertions leads to phenotypic plasticity that allows for the evasion of the host's defence system and pathogenesis. This paper compared for the first time the genomes of four human urogenital Mycoplasma species (M. penetrans HF-2, M. fermentans JER, M. genitalium G37 and M. hominis PG21) to categorise the metabolic functions of the core genes and to assess the effects of tandem repeats, phage-like genetic elements and prophages on the virulence genes...
September 5, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-%C3%A2-genitalium-prevalence-and-antimicrobial-resistance-in-m-%C3%A2-genitalium-in-denmark-norway-and-sweden-in-2016
#16
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Stezckó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new Conformité Européene (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28893363/high-levels-of-macrolide-resistant-mycoplasma-genitalium-in-queensland-australia
#17
Ella Trembizki, Cameron Buckley, Cheryl Bletchly, Graeme R Nimmo, David M Whiley
The macrolide azithromycin is recommended for treatment of Mycoplasma genitalium infection; however, M. genitalium strains possessing macrolide resistance-mediating mutations (MRMMs) are increasingly being reported. Here, we used the SpeeDx ResistancePlus MG kit, which provides simultaneous detection of M. genitalium and MRMMs, to assess MRMM carriage among M. genitalium infections in Queensland, Australia. Performance characteristics of the ResistancePlus MG kit for M. genitalium detection were compared to in-house PCR...
October 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28882163/prevalence-and-significance-of-mycoplasma-genitalium-in-women-living-with-hiv-in-denmark
#18
Anne Marie Rosendahl Madsen, Kristina Thorsteinsson, Anne-Mette Lebech, Merete Storgaard, Terese L Katzenstein, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Noerregaard Nielsen, Aase Bengaard Andersen, Jørgen Skov Jensen
OBJECTIVE: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. genitalium and HIV infection, therefore screening and treatment for M. genitalium has been suggested as part of HIV prevention strategies. The objective of this study was to determine the prevalence of M. genitalium in women living with HIV (WLWH) in Denmark, and to compare the result with data on symptoms from the lower abdomen, sexual habits and immune status...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28878004/mycoplasma-genitalium-macrolide-and-fluoroquinolone-resistance-detection-and-clinical-implications-in-a-selected-cohort-in-new-zealand
#19
Trevor Anderson, Edward Coughlan, Anja Werno
Mycoplasma genitalium has been associated with infections of the genitourinary tract, and prevalence is secondary to Chlamydia trachomatis The clinical observation of increasing treatment failure indicating antibiotic resistance, especially in cases of recurrent urethritis, has been confirmed by molecular testing. Mutations in the 23S rRNA gene can cause macrolide resistance, and topoisomerase/gyrase mutations can cause fluoroquinolone resistance. In this study, 115 M. genitalium DNA-positive samples were analyzed...
November 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28868962/prevalence-of-mycoplasma-genitalium-and-other-sexually-transmitted-infections-causing-urethritis-among-high-risk-heterosexual-male-patients-in-estonia
#20
Stanislav Tjagur, Reet Mändar, Margus Punab
BACKGROUND: We aimed to evaluate the prevalence of sexually transmitted infections (STI, including Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis) among high-risk heterosexual male patients and to clarify their potency to cause complaints and inflammation. METHODS: The study group included 825 men (18.0-49.5 y) consulting andrologist at Tartu University Hospital (Estonia) due to subjectively perceived risk of STI. Patients completed STI risk behaviour questionnaire...
September 4, 2017: Infectious Diseases
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