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Mycoplasma genitalium

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https://www.readbyqxmd.com/read/28301989/routine-testing-of-mycoplasma-genitalium-and-trichomonas-vaginalis
#1
Marieke L M Jenniskens, Jan H W Veerbeek, Koen L Deurloo, Erik J van Hannen, Steven F T Thijsen
BACKGROUND: Mycoplasma genitalium (MG) and Trichomonas vaginalis (TV) are common sexual transmitted infections (STI). However, most STI screening programmes do not include routinely detection of these pathogens. Consequently, epidemiological data about MG and TV in the general population is lacking. The current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. METHODS: Between February 2013 and August 2015, all samples sent to the laboratory of Diakonessenhuis Utrecht for STI testing (i...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28291669/mycoplasma-genitalium-in-spain-prevalence-of-genital-infection-and-frequency-of-resistance-to-macrolides
#2
Alejandra Asenjo, Johannes G Kusters, Tim T Severs, Juan-Ignacio Alós
INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015. METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced...
March 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28268197/microbial-invasion-of-the-amniotic-cavity-in-midtrimester-pregnancies-using-molecular-microbiology
#3
Shelley Rowlands, Jennifer A Danielewski, Sepehr N Tabrizi, Susan P Walker, Suzanne M Garland
OBJECTIVE: The objective of the study was to determine the frequency of microbial invasion of the amniotic cavity in the midtrimester of pregnancy in patients undergoing amniocentesis for clinical indications. STUDY DESIGN: This was a prospective investigation of the amniotic fluid of 344 asymptomatic women recruited in midpregnancy for the presence of microbial DNA. Amniotic samples obtained at the time of amniocentesis for genetic testing on women between 15 and 22 weeks of gestation were tested specifically for the presence of Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium as well as for other bacteria and fungi using broad-range polymerase chain reaction only...
March 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28263902/mollicutes-in-vaginal-microbiology-mycoplasma-hominis-ureaplasma-urealyticum-ureaplasma-parvum-and-mycoplasma-genitalium
#4
David Taylor-Robinson
Mycoplasma hominis was isolated in 1937 from the human genital tract, followed 17 years later by Ureaplasma urealyticum and 27 years after that by Mycoplasma genitalium. The first two proved relatively easy to culture but the latter required a polymerase chain reaction assay for further studies. In sexually mature women, M. hominis may be found in the vagina/cervix of about 20-50%, ureaplasmas in 40-80% and M. genitalium in 0-5%. Some heterogeneity has been found among strains of all these species, sufficient to divide ureaplasmas into two species, namely U...
March 2, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28260146/simultaneous-detection-and-identification-of-sti-pathogens-by-multiplex-real-time-pcr-in-genital-tract-specimens-in-a-selected-area-of-apulia-a-region-of-southern-italy
#5
Raffaele Del Prete, Luigi Ronga, Mirella Lestingi, Grazia Addati, Umberto Filippo Angelotti, Domenico Di Carlo, Giuseppe Miragliotta
PURPOSE: Genital tract infections are globally a major cause of morbidity in sexually active individuals. The aim of this study was to investigate the prevalence and associations of co-infections of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis (MH), Mycoplasma genitalium, Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) in specimens collected from female (SF) and male (SM) patients. METHODS: 1575 samples from 1575 individuals from the geographical area around Bari, Apulia region in Southern Italy, were collected and analyzed by a multiplex Real-Time PCR (mRT-PCR) (Anyplex(TM) II STI-7, Seegene, Inc...
March 4, 2017: Infection
https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#6
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28159916/impact-of-deploying-multiple-point-of-care-tests-with-a-sample-first-approach-on-a-sexual-health-clinical-care-pathway-a-service-evaluation
#7
Emma M Harding-Esch, Achyuta V Nori, Aseel Hegazi, Marcus J Pond, Olanike Okolo, Anthony Nardone, Catherine M Lowndes, Phillip Hay, S Tariq Sadiq
OBJECTIVES: To assess clinical service value of STI point-of-care test (POCT) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). Specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (NAAT) for Chlamydia trachomatis/Neisseria gonorrhoeae (CT/NG) could be used as a POCT in practice; feasibility of non-NAAT POCT implementation for Trichomonas vaginalis (TV) and bacterial vaginosis (BV); impact on patient diagnosis and treatment...
February 3, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28158595/high-prevalence-of-the-a2058t-macrolide-resistance-associated-mutation-in-mycoplasma-genitalium-strains-from-the-netherlands
#8
Joyce F Braam, Brenda Slotboom, Sebastian Van Marm, Tim T Severs, Noortje M Van Maarseveen, Ton Van Zwet, Edwin C H Boel, Hanneke Berkhout, Ferry Hagen, Jeroen H B Van De Bovenkamp, Laura Van Dommelen, Johannes G Kusters
No abstract text is available yet for this article.
February 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28118803/meta-analysis-of-the-efficacy-of-moxifloxacin-in-treating-mycoplasma-genitalium-infection
#9
Yang Li, Wen-Jing Le, Sai Li, Yu-Ping Cao, Xiao-Hong Su
Mycoplasma genitalium is an important pathogen that is transmitted through sexual contact. For patients diagnosed with M. genitalium infection, the current guidelines recommend 1 g of azithromycin as the first-line treatment. Moxifloxacin is used as a second-line drug due to its remarkable efficacy; however, increased use of moxifloxacin to treat M. genitalium infections has caused the emergence of cases of moxifloxacin treatment failure. This meta-analysis aims to estimate the treatment efficacy of moxifloxacin for M...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28114309/superior-multiplexing-capacity-of-plexprimers-enables-sensitive-and-specific-detection-of-snps-and-clustered-mutations-in-qpcr
#10
Lit Yeen Tan, Samantha Michelle Walker, Tina Lonergan, Nicole Elizabeth Lima, Alison Velyian Todd, Elisa Mokany
BACKGROUND: Whilst qPCR provides an extremely powerful tool for genetic analysis, some applications such as multiplexing variant alleles (eg SNPs, point mutations or deletions), remain challenging using current primer/probe systems. The novel design features of PlexPrimers allow sensitive, multiplexed analysis of variant alleles even when these are tightly clustered. METHOD: PlexPrimers were combined with PlexZymes in qPCR assays for the detection of SNPs in human absorption, distribution, metabolism, and excretion (ADME) genes; clustered mutations in the 23S rRNA gene which confer antibiotic resistance to Mycoplasma genitalium; and deletions within the human epidermal growth factor receptor (EGFR) gene...
2017: PloS One
https://www.readbyqxmd.com/read/28112332/-molecular-detection-of-sexually-transmitted-agents-in-a-symptomatic-group-of-men-and-its-relationship-with-sexual-behavior
#11
Daniela León, Javier Retamal, Ramón Silva, Carmen Ili, Stephanie Mieville, Pablo Guzmán, Gastón Briceño, Priscilla Brebi
BACKGROUND: Sexually transmitted infections (STIs) affect sexual and reproductive health of millions of men. Pathogens such as human papillomavirus (HPV), herpes simplex virus type 1 and 2 (HSV-1 y HSV-2), Chlamydia trachomatis,Mycoplasmagenitalium,Mycoplasma hominis and Ureaplasma urealyticum are associated with STIs. AIM: To detect pathogens associated with STIs in symptomatic men and its relationship with sexual behavior. METHODOLOGY: DNA was obtained from exfoliated cells of penis from 20 symptomatic men...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28099135/mycoplasma-ureaplasma-infection-in-pregnancy-to-screen-or-not-to-screen
#12
Gilbert G G Donders, Kateryna Ruban, Gert Bellen, Ljubomir Petricevic
Mycoplasmata have been linked to pregnancy complications and neonatal risk. While formerly a limited number of species could be discovered by cultures, molecular biology nowadays discovers both lower quantities and more diverse species, making us realize that mycoplasmata are ubiquitous in the vaginal milieu and do not always pose a danger for pregnant women. As the meaning of mycoplasmata in pregnancy is not clear to many clinicians, we summarized the current knowledge about the meaning of different kinds of mycoplasmata in pregnancy and discuss the potential benefits and disadvantages of treatment...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28079749/should-female-partners-of-men-with-non-gonococcal-urethritis-negative-for-chlamydia-trachomatis-and-mycoplasma-genitalium-be-informed-and-treated-clinical-outcomes-from-a-partner-study-of-heterosexual-men-with-ngu
#13
Jason J Ong, Angela Sarumpaet, Eric P F Chow, Catriona Bradshaw, Marcus Chen, Tim Read, Christopher K Fairley
BACKGROUND: To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection. METHODS: Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28072403/antimicrobial-resistant-sexually-transmitted-infections-gonorrhoea-and-mycoplasma-genitalium
#14
REVIEW
Magnus Unemo, Jorgen S Jensen
The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro and clinically, to essentially all antimicrobials available for treatment, causing exceedingly difficult-to-treat or untreatable STIs and threatening global public health. Widespread AMR in these bacteria is likely to persist and even worsen in the future, owing to the high number of infections, widespread and uncontrolled use of antimicrobials, limited surveillance of AMR and clinical failures, as well as the extraordinary capacity of these bacteria to develop AMR...
January 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28032361/relationship-between-chlamydia-trachomatis-and-mycoplasma-genitalium-infection-and-pregnancy-rate-and-outcome-in-iranian-infertile-couples
#15
L Dehghan Marvast, A Aflatoonian, A R Talebi, A Eley, A A Pacey
The study was performed to investigate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in a population of infertile couples from Iran and how this relates to tubal factor infertility, pregnancy rate and outcome of pregnancy. Blood, semen and first-void urine samples were obtained from 250 infertile couples and 250 fertile women as a control. Infertile couples were followed up after 24 months to determine diagnosis, referral for assisted conception, any pregnancy and pregnancy outcome. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C...
December 29, 2016: Andrologia
https://www.readbyqxmd.com/read/28031435/evaluation-of-a-commercial-multiplex-quantitative-pcr-qpcr-assay-for-simultaneous-detection-of-mycoplasma-genitalium-and-macrolide-resistance-associated-mutations-in-clinical-specimens
#16
LETTER
Chloé Le Roy, Nadège Hénin, Cécile Bébéar, Sabine Pereyre
No abstract text is available yet for this article.
March 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28011607/azithromycin-1-5g-over-5-days-compared-to-1g-single-dose-in-urethral-mycoplasma-genitalium-impact-on-treatment-outcome-and-resistance
#17
Tim R H Read, Christopher K Fairley, Sepehr N Tabrizi, Melanie Bissessor, Lenka Vodstrcil, Eric P F Chow, Mieken Grant, Jennifer Danielewski, Suzanne M Garland, Jane S Hocking, Marcus Y Chen, Catriona S Bradshaw
BACKGROUND: We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 and compared this to cases treated with azithromycin 1g in 2012-2013. METHODS: Microbiological cure was determined for men with M. genitalium urethritis treated with azithromycin 1.5g using quantitative polymerase chain reaction specific for M. genitalium DNA on samples 14-100 days post-treatment...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28007229/sexually-transmitted-diseases-and-infertility
#18
REVIEW
Danielle G Tsevat, Harold C Wiesenfeld, Caitlin Parks, Jeffrey F Peipert
Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27981387/-non-viral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostics-and-therapy-part%C3%A2-2-chlamydia-and-mycoplasma
#19
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
Chlamydia trachomatis is the most common pathogen of sexually transmitted bacterial infections worldwide. Every year in Germany approximately 300,000 new infections are to be expected. Chlamydia infections occur nearly exclusively in the postpubertal period. The peak age group is 15-25 years. The infection usually runs an asymptomatic course and the diagnosis is made by nucleic acid amplification techniques (NAAT) often after chlamydial screening or if complications occur. For treatment of chlamydial infections oral doxycycline 100 mg twice daily over 7 days is initially used or alternatively oral azithromycin 1...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27935945/correction-improved-metabolic-models-for-e-coli-and-mycoplasma-genitalium-from-globalfit-an-algorithm-that-simultaneously-matches-growth-and-non-growth-data-sets
#20
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1005036.].
December 2016: PLoS Computational Biology
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