keyword
https://read.qxmd.com/read/38534082/extragenital-sexually-transmitted-infections-among-high-risk-men-who-have-sex-with-men-in-johannesburg-south-africa
#1
JOURNAL ARTICLE
Bianca Da Costa Dias, Windy Sekgele, Duduzile Nhlapo, Mahlape P Mahlangu, Johanna M E Venter, Dumisile V Maseko, Etienne E Müller, Maurice Greeves, Paul Botha, Frans Radebe, Tendesayi Kufa, Ranmini S Kularatne
BACKGROUND: In South Africa, extragenital etiological sexually transmitted infection (STI) screening among men who have sex with men (MSM) is not routinely available. We aimed to determine the prevalence of STI pathogens at rectal and pharyngeal sites, syphilis seroprevalence, and associated risk factors among a selection of high-risk MSM without symptomatic urethritis attending a men's health clinic in Johannesburg, South Africa. METHODS: A cross-sectional study was conducted in 2022...
April 1, 2024: Sexually Transmitted Diseases
https://read.qxmd.com/read/38509173/antimicrobial-treatment-and-resistance-in-sexually-transmitted-bacterial-infections
#2
REVIEW
Jorgen S Jensen, Magnus Unemo
Sexually transmitted infections (STIs) have been part of human life since ancient times, and their symptoms affect quality of life, and sequelae are common. Socioeconomic and behavioural trends affect the prevalence of STIs, but the discovery of antimicrobials gave hope for treatment, control of the spread of infection and lower rates of sequelae. This has to some extent been achieved, but increasing antimicrobial resistance and increasing transmission in high-risk sexual networks threaten this progress. For Neisseria gonorrhoeae, the only remaining first-line treatment (with ceftriaxone) is at risk of becoming ineffective, and for Mycoplasma genitalium, for which fewer alternative antimicrobial classes are available, incurable infections have already been reported...
March 20, 2024: Nature Reviews. Microbiology
https://read.qxmd.com/read/38504874/-mycoplasma-genitalium-infection-among-gay-bisexual-and-other-men-who-have-sex-with-men-in-montr%C3%A3-al-canada
#3
JOURNAL ARTICLE
Anne-Sophie Lê, Annie-Claude Labbé, Alain Fourmigue, Milada Dvorakova, Joseph Cox, Claude Fortin, Irene Martin, Daniel Grace, Trevor Hart, David Moore, Gilles Lambert
BACKGROUND: The bacteria Mycoplasma genitalium has been identified as a causative agent of urethritis in men, especially in gay, bisexual and other men who have sex with men (gbMSM). Canadian clinic-based data have identified a high prevalence of M. genitalium and resistance to antibiotic treatments. This article estimates the prevalence of M. genitalium infections among Montréal gbMSM, explores correlates for M. genitalium infection and estimates the prevalence of mutations associated with antimicrobial resistance (AMR)...
November 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38491782/treatment-of-mycoplasma-genitalium-infection-in-pregnancy-a%C3%A2-systematic-review-of-international-guidelines
#4
REVIEW
Richard J Drew, Maeve Eogan
BACKGROUND: Mycoplasma genitalium is an emerging pathogen, which has been linked to cervicitis, urethritis and pelvic inflammatory disease (PID). With the advent of multiplex polymerase chain reaction (PCR) panels for sexually transmitted infections, it is increasingly being identified in pregnant women. OBJECTIVES: The aim was to review international guidelines, which had explicit recommendations for treatment of M. genitalium infection in pregnancy and breastfeeding...
March 15, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38465972/comparative-clinical-evaluation-of-the-alinity-m-sti-multiplex-pcr-assay-for-diagnosis-and-surveillance-of-chlamydia-trachomatis-neisseria-gonorrhea-trichomonas-vaginalis-and-mycoplasma-genitalium
#5
JOURNAL ARTICLE
Amorce Lima, Dominic Uy, Joshua Kostera, Suzane Silbert
BACKGROUND: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are routinely tested and reported; however, Trichomonas vaginalis (TV) is the most common STI in the US and the prevalence of Mycoplasma genitalium (MG) infections is likely higher than estimated. We examined the clinical performance of the Alinity m STI assay for detection and surveillance of CT/NG/TV/MG in urine specimens from patients at a large academic medical center. METHODS: Urine specimen from 198 patients were tested in this evaluation...
March 4, 2024: Sexually Transmitted Diseases
https://read.qxmd.com/read/38425195/prevalence-of-chlamydia-trachomatis-neisseria-gonorrhoeae-trichomonas-vaginalis-and-mycoplasma-genitalium-and-risk-factors-among-pregnant-women-in-brazil-results-from-the-national-molecular-diagnosis-implementation-project
#6
JOURNAL ARTICLE
Angélica Espinosa Miranda, Pâmela Cristina Gaspar, Marcos André Schörner, Fernando Hartmann Barazzetti, Guilherme Borges Dias, Alisson Bigolin, Ana Roberta Pati Pascom, Dráurio Barreira, Maria Luiza Bazzo
BACKGROUND: Sexually transmitted infections (STIs) are a public health problem. The aim of the present study was to assess the prevalence and risk factors associated with at least one STI (Chlamydia trachomatis [CT], Neisseria gonorrhoeae [NG], Trichomonas vaginalis [TV], and Mycoplasma genitalium [MG]) in Brazil. METHODS: A cross-sectional study was conducted using secondary data from the pilot implementation of the National Service for molecular diagnosis of CT, NG, TV, and MG in pregnancy...
February 29, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38390016/-tropical-sexually-transmitted-infections-summary-of-the-sfmtsi-scientific-day-of-november-9-2023
#7
JOURNAL ARTICLE
Éric Caumes
Sexually transmitted infections (STIs) deserve more attention today than ever in the tropics. Indeed, the emergence of monkeypox in 2022 in Western countries reminds the risk of exporting STIs from the tropics as it was already known for decades with the worldwide spread of HIV/AIDS infection from tropical Africa. Some hazards are already well identified. According to WHO 2023 report STIs are increasing in the world. Antibiotic resistance is increasing for Neisseria gonorrhoeae, and already well established for Mycoplasma genitalium, whereas Treponema pallidum has become resistant to macrolides within the last twenty years...
December 31, 2023: Med Trop Sante Int
https://read.qxmd.com/read/38372542/prospective-cohort-study-of-treatment-outcomes-of-vaginal-discharge-syndrome-in-women-in-windhoek-namibia
#8
JOURNAL ARTICLE
Cara M Dunaiski, Marleen M Kock, Hyunsul Jung, Remco P H Peters
BACKGROUND: Syndromic treatment is the standard of care for vaginal discharge syndrome (VDS) in resource-constrained settings. However, the outcomes of VDS treatment have not been well documented. This study aimed to determine the incidence, risk factors, and microbial etiology of treatment failure in women with VDS. METHODS: This prospective cohort study of women with VDS was conducted between September 2021 and March 2022 at Katutura Intermediate Hospital in Windhoek, Namibia...
February 19, 2024: Sexually Transmitted Diseases
https://read.qxmd.com/read/38372541/sti-prevalence-partner-notification-and-hiv-risk-perception-in-a-cohort-of-women-completing-sti-screening-as-part-of-a-safer-conception-study
#9
JOURNAL ARTICLE
Ivana Beesham, Oluwaseyi Isehunwa, Yolandie Kriel, Manjeetha Jaggernath, Kara Bennett, Kathleen Hurwitz, Patricia M Smith, Pooja Chitneni, Shannon Bosman, David R Bangsberg, Jeanne M Marrazzo, Jennifer A Smit, Lynn T Matthews
BACKGROUND: Integrating STI and pre-exposure prophylaxis (PrEP) care may optimize sexual and reproductive health. METHODS: We nested an STI-sub-study within an HIV prevention cohort (Parent study) of 18-35-year-old women from South Africa, planning pregnancy with a partner with HIV or of unknown-serostatus. Parent-study women completed annual surveys regarding HIV-risk perceptions and were offered oral PrEP. PrEP initiators completed quarterly plasma tenofovir testing...
February 19, 2024: Sexually Transmitted Diseases
https://read.qxmd.com/read/38362626/estimation-of-antimicrobial-resistance-of-mycoplasma-genitalium-belgium-2022
#10
JOURNAL ARTICLE
Irith De Baetselier, Hilde Smet, Kaat Kehoe, Imelda Loosen, Marijke Reynders, Iqbal Mansoor, Lorenzo Filippin, Mathieu Cauchie, Ellen Van Even, Nadia Makki, Gilberte Schiettekatte, Wouter Vandewal, Bart Glibert, Veerle Matheeussen, Yolien Van der Beken, Reinoud Cartuyvels, Sophia Steyaert, Ann Lemmens, Maria-Grazia Garrino, Henry Paridaens, Elena Lazarova, Bénédicte Lissoir, Marine Deffontaine, Amélie Heinrichs, Veroniek Saegeman, Elizaveta Padalko, Amaryl Lecompte, Wim Vanden Berghe, Chris Kenyon, Dorien Van den Bossche
BackgroundAntimicrobial resistance (AMR) of Mycoplasma genitalium (MG) is a growing concern worldwide and surveillance is needed. In Belgium, samples are sent to the National Reference Centre of Sexually Transmitted Infections (NRC-STI) on a voluntary basis and representative or robust national AMR data are lacking.AimWe aimed to estimate the occurrence of resistant MG in Belgium.MethodsBetween July and November 2022, frozen remnants of MG-positive samples from 21 Belgian laboratories were analysed at the NRC-STI...
February 2024: Euro Surveillance
https://read.qxmd.com/read/38360847/aetiological-molecular-identification-of-sexually-transmitted-infections-that-cause-urethral-discharge-syndrome-and-genital-ulcer-disease-in-brazilian-men-a-nationwide-study
#11
JOURNAL ARTICLE
Maria Luiza Bazzo, Hanalydia de Melo Machado, Jessica Motta Martins, Marcos André Schörner, Ketlyn Buss, Fernando Hartmann Barazzetti, Pamela Cristina Gaspar, Alisson Bigolin, Adele Benzaken, Simone Veloso Faria de Carvalho, Lidiane da Fonseca Andrade, William Antunes Ferreira, François Figueiroa, Rafael Mialski Fontana, Miralba Freire de Carvalho Ribeiro da Silva, Roberto José Carvalho Silva, Luiz Fernando Aires Junior, Lis Aparecida de Souza Neves, Angelica Espinosa Miranda, Brazilian-Gasp Network
BACKGROUND: Little is known about the aetiology of urethral discharge syndrome (UDS) and genital ulcer disease (GUD) in Brazil due to limited access to laboratory tests and treatment based mainly on the syndromic approach. OBJECTIVES: To update Brazilian treatment guidelines according to the current scenario, the first nationwide aetiological study for UDS and GUD was performed. METHODS: Male participants with urethral discharge (UD) and/or genital ulcer (GU) reports were enrolled...
February 15, 2024: Sexually Transmitted Infections
https://read.qxmd.com/read/38349187/detection-of-resistance-to-macrolides-and-fluoroquinolones-in-mycoplasma-genitalium-by-targeted-next-generation-sequencing
#12
JOURNAL ARTICLE
Calin B Chiribau, Sarah Schmedes, Yibo Dong, Namratha Tarigopula, Omer Tekin, Andrew Cannons, Jill Roberts, Donna Haiduven, Susanne R Crowe
Mycoplasma genitalium is fastidious to culture, and its detection in human clinical specimens relies mainly on molecular methods. Phenotypic determination of antibiotic susceptibility for this bacterium is not a timely or feasible option for most clinical laboratories. This study sought to determine whether next-generation sequencing technologies can effectively be employed in determining genetic mutations associated with drug resistance in M. genitalium samples collected in Aptima Hologic tubes and possibly integrating them into viable workflows in public health laboratories...
February 13, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38346403/prevalence-of-urogenital-mycoplasma-genitalium-infection-at-two-us-army-medical-facilities
#13
JOURNAL ARTICLE
Matthew L Romo, Sarah C Moreland, Adam M Yates, Trevor A Crowell, Maureen Sevilla, John L MacArthur, Paul Faestel, Anjali Kunz, Julie A Ake, Tatjana Calvano, Donn J Colby
BACKGROUND: Sexually transmitted infections (STIs) have a high incidence in the US Armed Forces and can adversely impact service members' ability to perform their duties. Better knowledge of Mycoplasma genitalium (MG) epidemiology in the military is needed to understand the potential impact of this emerging pathogen on force readiness. METHODS: We conducted cross-sectional analyses of data from US Army service members and other Military Health System beneficiaries participating in a trial of an STI/HIV behavioral intervention at Fort Liberty, NC and Joint Base Lewis-McChord, WA...
February 12, 2024: Sexually Transmitted Diseases
https://read.qxmd.com/read/38331484/proctitis-an-approach-to-the-symptomatic-patient
#14
REVIEW
Candice J McNeil, Luis F Barroso, Kimberly Workowski
Proctitis is an inflammatory condition of the distal rectum that can be associated with common sexually transmitted infections (STIs), such as gonorrhea, chlamydia, and syphilis. For persons presenting with ulcerative findings on examination, in addition to syphilis, Mpox, lymphogranuloma venereum, and herpes simplex virus should be in the differential. Providers should also be aware that there are evolving data to support a role for Mycoplasma genitalium in proctitis. Performing a comprehensive history, clinical evaluation including anoscopy, and rectal nucleic amplification STI testing may be useful in identifying the cause of proctitis and targeting treatment...
March 2024: Medical Clinics of North America
https://read.qxmd.com/read/38331481/mycoplasma-genitalium-key-information-for-the-primary-care-clinician
#15
REVIEW
Oluyomi A Obafemi, Sarah E Rowan, Masayo Nishiyama, Karen A Wendel
Mycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend testing for persistent male urethritis, cervicitis, and proctitis and state that testing should be considered in cases of PID...
March 2024: Medical Clinics of North America
https://read.qxmd.com/read/38292654/near-to-patient-testing-to-inform-targeted-antibiotic-use-for-sexually-transmitted-infections-in-a-public-sexual-health-clinic-the-neptune-cohort-study
#16
JOURNAL ARTICLE
Lenka A Vodstrcil, Kay Htaik, Erica L Plummer, Vesna De Petra, Melodi G Sen, Deborah A Williamson, Jason J Ong, Jason Wu, Monica Owlad, Gerald Murray, Eric P F Chow, Christopher K Fairley, Catriona S Bradshaw
BACKGROUND: Empiric treatment of sexually transmitted infections can cause unnecessary antibiotic use. We determined if near-to-patient-testing (NPT) for Neisseria gonorrhoeae , Chlamydia trachomatis and Mycoplasma genitalium (MG) improved antibiotic-use for a range of clinical presentations. METHODS: Clients attending with non-gonococcal urethritis (NGU), proctitis, as STI-contacts, or for an MG-test-of-cure (MG-TOC) between March and December 2021 were recruited...
March 2024: The Lancet Regional Health. Western Pacific
https://read.qxmd.com/read/38289395/modelling-of-doxycycline-based-prevention-of-bacterial-sexually-transmitted-infections-in-comparison-to-condom-based-and-test-based-prevention
#17
JOURNAL ARTICLE
Andreas Hahn, Hagen Frickmann, Ulrike Loderstädt
BACKGROUND: Doxycycline-based prevention of bacterial sexually transmitted infections (STIs) has been assessed in various studies and has been recommended by the European AIDS Clinical Society to be proposed to persons with repeated STIs on a case-by-case basis. However, while good preventive effects could be shown for Chlamydia trachomatis and Treponema pallidum in Europe, no reliable prevention against doxycycline resistance-affected bacterial causes of STIs like Neisseria gonorrhoeae and Mycoplasma genitalium was confirmed...
January 30, 2024: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/38244245/comparison-of-two-testing-strategies-for-mycoplasma-genitalium-in-emergency-department-patients-across-a-statewide-health-system
#18
JOURNAL ARTICLE
Emily Johnson, Molly Tieman, Krista Dumkow, Emily Pavich
PURPOSE: Mycoplasma genitalium (Mgen) is a sexually transmitted infection (STI) that has an estimated prevalence in the general population of 2.3% in women and 1.1% in men aged 21-23 years. (Hilbert and Reno, 2018) A cross-sectional study conducted in a community emergency department (ED) determined that the prevalence of Mgen was 14.8% in asymptomatic female patients. (Centers for Disease Control and Prevention (CDC). Sexually Transmitted Infections Treatment Guidelines, 2021) The Centers for Disease Control and Prevention (CDC) 2021 STI Treatment Guidelines recommend testing for Mgen in select circumstances...
January 12, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38197747/2023-korean-sexually-transmitted-infections-treatment-guidelines-for-mycoplasma-genitalium-by-kautii
#19
REVIEW
Seung-Ju Lee, Jin Bong Choi, Sangrak Bae, Seong Woong Na, Hae Do Jung, Hyun Jin Jung, Seung Il Jung, Phil Hyun Song, Gilho Lee
The Korean Association of Urogenital Tract Infection and Inflammation and the Korea Disease Control and Prevention Agency updated the Korean sexually transmitted infections (STIs) guidelines to respond to the changing epidemiologic trends, evolving scientific evidence, and advances in laboratory diagnostics and research. The main recommendations in the Mycoplasma genitalium infection parts of the Korean STIs guidelines 2023 revision are as follows: 1) For initial treatment: azithromycin 500 mg orally in a single dose, then 250 mg once daily for 4 days...
January 2024: Investigative and Clinical Urology
https://read.qxmd.com/read/38187347/the-association-between-non-viral-sexually-transmitted-infections-and-pregnancy-outcome-in-latin-america-and-the-caribbean-a-systematic-review
#20
JOURNAL ARTICLE
Maria Lara-Escandell, Carlotta Gamberini, Naomi C A Juliana, Salwan Al-Nasiry, Servaas A Morré, Elena Ambrosino
INTRODUCTION: Non-viral sexually transmitted infections are known to be associated with adverse pregnancy outcomes. For these pathogens, standard antenatal screening is not broadly performed in Latin America and the Caribbean. The aim of this study was to comprehensively review the association of non-viral sexually transmitted infections and neonatal outcomes among pregnant women in the region. METHODS: Four databases (PubMed, Embase, SciELO and LILACS) were examined to identify eligible studies published up to September 2022...
January 15, 2024: Heliyon
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