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Boris Julg, Amarendra Pegu, Peter Abbink, Jinyan Liu, Amanda Brinkman, Katherine Molloy, Shanell Mojta, Abishek Chandrashekar, Katherine Callow, Keyun Wang, Xuejun Chen, Stephen D Schmidt, Jinghe Huang, Richard A Koup, Michael S Seaman, Brandon F Keele, John R Mascola, Mark Connors, Dan H Barouch
Passive immunotherapy against HIV-1 will most likely require broadly neutralizing antibodies (bnAbs) with maximum breadth and potency to ensure therapeutic efficacy. Recently, the novel CD4 binding site antibody N6 demonstrated extraordinary neutralization breadth and potency against large panels of cross-clade pseudoviruses. We evaluated the in vivo antiviral activity of N6-LS, alone or in combination with the established V3-glycan antibody PGT121, in chronically simian-human immunodeficiency virus (SHIV)-SF162P3-infected macaques...
August 15, 2017: Journal of Virology
Malika Aid, Peter Abbink, Rafael A Larocca, Michael Boyd, Ramya Nityanandam, Ovini Nanayakkara, Amanda J Martinot, Edward T Moseley, Eryn Blass, Erica N Borducchi, Abishek Chandrashekar, Amanda L Brinkman, Katherine Molloy, David Jetton, Lawrence J Tartaglia, Jinyan Liu, Katharine Best, Alan S Perelson, Rafael A De La Barrera, Mark G Lewis, Dan H Barouch
Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study...
May 4, 2017: Cell
Katrina M Morris, Denis O'Meally, Thiri Zaw, Xiaomin Song, Amber Gillett, Mark P Molloy, Adam Polkinghorne, Katherine Belov
Production of milk is a key characteristic of mammals, but the features of lactation vary greatly between monotreme, marsupial and eutherian mammals. Marsupials have a short gestation followed by a long lactation period, and milk constituents vary greatly across lactation. Marsupials are born immunologically naïve and rely on their mother's milk for immunological protection. Koalas (Phascolarctos cinereus) are an iconic Australian species that are increasingly threatened by disease. Here we use a mammary transcriptome, two milk proteomes and the koala genome to comprehensively characterise the protein components of koala milk across lactation, with a focus on immune constituents...
October 7, 2016: Scientific Reports
Peter Abbink, Rafael A Larocca, Rafael A De La Barrera, Christine A Bricault, Edward T Moseley, Michael Boyd, Marinela Kirilova, Zhenfeng Li, David Ng'ang'a, Ovini Nanayakkara, Ramya Nityanandam, Noe B Mercado, Erica N Borducchi, Arshi Agarwal, Amanda L Brinkman, Crystal Cabral, Abishek Chandrashekar, Patricia B Giglio, David Jetton, Jessica Jimenez, Benjamin C Lee, Shanell Mojta, Katherine Molloy, Mayuri Shetty, George H Neubauer, Kathryn E Stephenson, Jean Pierre S Peron, Paolo M de A Zanotto, Johnathan Misamore, Brad Finneyfrock, Mark G Lewis, Galit Alter, Kayvon Modjarrad, Richard G Jarman, Kenneth H Eckels, Nelson L Michael, Stephen J Thomas, Dan H Barouch
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico...
September 9, 2016: Science
Alice Coffey, Geraldine McCarthy, Elizabeth Weathers, M Isabel Friedman, Katherine Gallo, Mally Ehrenfeld, Sophia Chan, William H C Li, Piera Poletti, Renzo Zanotti, D William Molloy, Ciara McGlade, Joyce J Fitzpatrick, Michal Itzhaki
Nurses' knowledge regarding advance directives may affect their administration and completion in end-of-life care. Confidence among nurses is a barrier to the provision of quality end-of-life care. This study investigated nurses' knowledge of advance directives and perceived confidence in end-of-life care, in Hong Kong, Ireland, Israel, Italy and the USA using a cross-sectional descriptive design (n = 1089). In all countries, older nurses and those who had more professional experience felt more confident managing patients' symptoms at end-of-life and more comfortable stopping preventive medications at end-of-life...
June 2016: International Journal of Nursing Practice
Debra L Roter, Lori H Erby, Rajiv N Rimal, Katherine C Smith, Susan Larson, Ian M Bennett, Katie Washington Cole, Yue Guan, Matthew Molloy, Jessica Bienstock
This study was designed to evaluate the impact of an interactive computer program developed to empower prenatal communication among women with restricted literacy skills. A total of 83 women seeing 17 clinicians were randomized to a computer-based communication activation intervention (Healthy Babies Healthy Moms [HBHM]) or prenatal education (Baby Basics [BB]) prior to their prenatal visit. Visit communication was coded with the Roter Interaction Analysis System, and postvisit satisfaction was reported. Participants were on average 24 years of age and 25 weeks pregnant; 80% were African American...
2015: Journal of Health Communication
Anna M Seekatz, Casey M Theriot, Caitlyn T Molloy, Katherine L Wozniak, Ingrid L Bergin, Vincent B Young
Recurrent Clostridium difficile infection (CDI) is of particular concern among health care-associated infections. The role of the microbiota in disease recovery is apparent given the success of fecal microbiota transplantation (FMT) for recurrent CDI. Here, we present a murine model of CDI relapse to further define the microbiota recovery following FMT. Cefoperazone-treated mice were infected with C. difficile 630 spores and treated with vancomycin after development of clinical disease. Vancomycin treatment suppressed both C...
October 2015: Infection and Immunity
Timothy J Peters, Michael J Buckley, Aaron L Statham, Ruth Pidsley, Katherine Samaras, Reginald V Lord, Susan J Clark, Peter L Molloy
BACKGROUND: The identification and characterisation of differentially methylated regions (DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We present a novel method, DMRcate, that fits replicated methylation measurements from the Illumina HM450K BeadChip (or 450K array) spatially across the genome using a Gaussian kernel. DMRcate identifies and ranks the most differentially methylated regions across the genome based on tunable kernel smoothing of the differential methylation (DM) signal...
2015: Epigenetics & Chromatin
Claire E Kelly, Jeanie L Y Cheong, Carly Molloy, Peter J Anderson, Katherine J Lee, Alice C Burnett, Alan Connelly, Lex W Doyle, Deanne K Thompson
BACKGROUND: Adolescents born extremely preterm (EP; <28 weeks' gestation) and/or extremely low birthweight (ELBW; <1000 g) experience high rates of visual impairments, however the potential neural correlates of visual impairments in EP/ELBW adolescents require further investigation. This study aimed to: 1) compare optic radiation and primary visual cortical structure between EP/ELBW adolescents and normal birthweight controls; 2) investigate associations between perinatal factors and optic radiation and primary visual cortical structure in EP/ELBW adolescents; 3) investigate associations between optic radiation and primary visual cortical structure in EP/ELBW adolescents and the odds of impaired vision...
2014: PloS One
Jeanie L Y Cheong, Peter J Anderson, Gehan Roberts, Alice C Burnett, Katherine J Lee, Deanne K Thompson, Carly Molloy, Michelle Wilson-Ching, Alan Connelly, Marc L Seal, Stephen J Wood, Lex W Doyle
OBJECTIVES: Extremely preterm (EP) survivors have smaller brains, lower IQ, and worse educational achievement than their term-born peers. The contribution of smaller brain size to the IQ and educational disadvantages of EP is unknown. This study aimed (i) to compare brain volumes from multiple brain tissues and structures between EP-born (< 28 weeks) and term-born (≥ 37 weeks) control adolescents, (ii) to explore the relationships of brain tissue volumes with IQ and basic educational skills and whether this differed by group, and (iii) to explore how much total brain tissue volume explains the underperformance of EP adolescents compared with controls...
2013: PloS One
Nathaniel Liddy, Giovanna Bossi, Katherine J Adams, Anna Lissina, Tara M Mahon, Namir J Hassan, Jessie Gavarret, Frayne C Bianchi, Nicholas J Pumphrey, Kristin Ladell, Emma Gostick, Andrew K Sewell, Nikolai M Lissin, Naomi E Harwood, Peter E Molloy, Yi Li, Brian J Cameron, Malkit Sami, Emma E Baston, Penio T Todorov, Samantha J Paston, Rebecca E Dennis, Jane V Harper, Steve M Dunn, Rebecca Ashfield, Andy Johnson, Yvonne McGrath, Gabriela Plesa, Carl H June, Michael Kalos, David A Price, Annelise Vuidepot, Daniel D Williams, Deborah H Sutton, Bent K Jakobsen
T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a minority of patients with cancer. In the majority of these individuals, however, there is a failure of the specific T cell receptor (TCR)–mediated immune recognition and activation process. Here we describe the engineering and characterization of new reagents termed immune-mobilizing monoclonal TCRs against cancer (ImmTACs). Four such ImmTACs, each comprising a distinct tumor-associated epitope-specific monoclonal TCR with picomolar affinity fused to a humanized cluster of differentiation 3 (CD3)-specific single-chain antibody fragment (scFv), effectively redirected T cells to kill cancer cells expressing extremely low surface epitope densities...
June 2012: Nature Medicine
Michele M Schantz, Mary Bedner, Stephen E Long, John L Molloy, Karen E Murphy, Barbara J Porter, Karsten Putzbach, Catherine A Rimmer, Lane C Sander, Katherine E Sharpless, Jeanice B Thomas, Stephen A Wise, Laura J Wood, James H Yen, Takashi Yarita, Agnes NguyenPho, Wendy R Sorenson, Joseph M Betz
As part of a collaboration with the National Institutes of Health's Office of Dietary Supplements and the Food and Drug Administration's Center for Drug Evaluation and Research, the National Institute of Standards and Technology has developed two standard reference materials (SRMs) representing different forms of saw palmetto (Serenoa repens), SRM 3250 Serenoa repens fruit and SRM 3251 Serenoa repens extract. Both of these SRMs have been characterized for their fatty acid and phytosterol content. The fatty acid concentration values are based on results from gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC/MS) analysis while the sterol concentration values are based on results from GC-FID and liquid chromatography with mass spectrometry analysis...
October 2008: Analytical and Bioanalytical Chemistry
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