keyword
https://read.qxmd.com/read/38375664/dermal-absorption-of-cyclic-and-linear-siloxanes-a-review
#21
REVIEW
Harvey Clewell, Tracy Greene, Robinan Gentry
Cyclic and linear siloxanes are compounds synthesized from silicon consisting of alternating atoms of silicone and oxygen [Si-O] units with organic side chains. The most common cyclic siloxanes are octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), while the most common linear siloxanes are high molecular weight polydimethylsiloxanes (PDMS) and low molecular weight volatile linear siloxanes known as hexamethyldisiloxane (L2), octamethyltrisiloxane (L3), decamethyltetrasiloxane (L4), dodecamethylpentasiloxane (L5)...
February 20, 2024: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://read.qxmd.com/read/38371137/the-management-of-plaque-psoriasis-with-halobetasol-and-tacrolimus-combination-therapy-versus-calcipotriol-monotherapy-a-case-report
#22
Mohammed Z Sarwar, Nawaid H Khan, MIrza Masroor Ali Beg, Niloufer Mariam Javeed Ankolvi, Kudaibergen Osmonaliev
Psoriasis is an inflammatory, immune-mediated, persistent, and multifactorial skin disease. Chronic plaque psoriasis is the most common clinical form of psoriasis. Pro-inflammatory cytokines play a primary role in the pathogenicity of this disease. Psoriasis is mainly diagnosed using clinical and dermoscopic examination of the cutaneous lesions, and skin biopsy is used in atypical cases. Psoriasis has no definitive cure. However, several topical agents are effective in managing mild and chronic cases. Combination therapy with these topical agents is more effective than with a single agent...
January 2024: Curēus
https://read.qxmd.com/read/38351985/the-effect-of-osthole-on-transient-receptor-potential-channels-a-possible-alternative-therapy-for-atopic-dermatitis
#23
JOURNAL ARTICLE
Natalia Karolina Kordulewska, Angelika Król-Grzymała
INTRODUCTION: Chronic recurrent skin inflammation and severe itching in patients with atopic dermatitis (AD) significantly impair their quality of life. The H4 histamine receptor plays a key role in histamine-induced itching. During the skin inflammation associated with AD, pro-inflammatory mediators (interleukins, cytokines) are released from neurons. Ultimately, a cascade of reactions leads to the activation and sensitization of transient receptor potential channels (TRP), which exacerbate the inflammation and itching associated with AD...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38337555/should-emollients-be-recommended-for-the-prevention-of-atopic-dermatitis-new-evidence-and-current-state-of-knowledge
#24
REVIEW
Magdalena Grześk-Kaczyńska, Justyna Petrus-Halicka, Szymon Kaczyński, Zbigniew Bartuzi, Natalia Ukleja-Sokołowska
INTRODUCTION: Atopic dermatitis (AD) is a chronic, pruritic skin disease with complex pathogenesis, which affects about 43 million children aged 1-4 years. One of the most known methods of alleviating symptoms of AD is emollient treatment, which varies depending on formulation and additional active ingredients. There is some evidence that emollients could be used in AD prevention in high-risk children. MATERIALS AND METHODS: A search of the literature from Cochrane Library, PubMed and Medline was conducted between August and September 2023 with the following keywords: "atopic dermatitis", "emollients", and "prevention"...
February 1, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38333201/small-angle-neutron-scattering-insights-into-2-ethylhexyl-laurate-a-remarkable-bioester
#25
JOURNAL ARTICLE
Oliver S Hammond, Daniel C Morris, Guillaume Bousrez, Sichao Li, Liliana de Campo, Carl Recsei, Michael Moir, Sergei Glavatskih, Mark W Rutland, Anja-Verena Mudring
Commercial (protiated) samples of the "green" and biodegradable bioester 2-ethylhexyl laurate (2-EHL) were mixed with D-2-EHL synthesized by hydrothermal deuteration, with the mixtures demonstrating bulk structuring in small-angle neutron scattering measurements. Analysis in a polymer scattering framework yielded a radius of gyration ( R g ) of 6.5 Å and a Kuhn length (alternatively described as the persistence length or average segment length) of 11.2 Å. Samples of 2-EHL dispersed in acetonitrile formed self-assembled structures exceeding the molecular dimensions of the 2-EHL, with a mean aggregation number ( N agg ) of 3...
February 5, 2024: ACS Sustainable Chemistry & Engineering
https://read.qxmd.com/read/38312314/interaction-between-the-microbiota-and-the-skin-barrier-in-aging-skin-a-comprehensive-review
#26
REVIEW
Yu Ri Woo, Hei Sung Kim
The interplay between the microbes and the skin barrier holds pivotal significance in skin health and aging. The skin and gut, both of which are critical immune and neuroendocrine system, harbor microbes that are kept in balance. Microbial shifts are seen with aging and may accelerate age-related skin changes. This comprehensive review investigates the intricate connection between microbe dynamics, skin barrier, and the aging process. The gut microbe plays essential roles in the human body, safeguarding the host, modulating metabolism, and shaping immunity...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38294264/-diagnosis-and-management-of-pruritus-associated-with-chronic-kidney-disease-in-hemodialyzed-patients
#27
JOURNAL ARTICLE
Antoine Lanot, Laurent Misery, Guy Rostoker, Angelo Testa, Philippe Chauveau, Maxime Touzot, Nans Florens, Pierre Bataille
Chronic kidney disease-associated pruritus (CKD-aP) is a disabling symptom which is frequent and often underestimated. Pa-MRC has a negative impact on quality of life, and is frequently accompanied by sleep disorders and depression. The approval of difelikefalin – a kappa opioid receptor agonist – in this indication requires updated recommendations. As a first step, secondary causes of pruritus without skin lesions must be ruled out, and general measures taken (emollients, psychological support, optimization of dialysis, normalization of serum calcium, phosphate and PTH in the range proposed by the KGIDO guidelines, treatment of iron deficiency)...
January 31, 2024: Néphrologie & Thérapeutique
https://read.qxmd.com/read/38287323/m%C3%A4-nuka-oil-based-ecmt-154-versus-vehicle-control-for-the-topical-treatment-of-eczema-study-protocol-for-a-randomised-controlled-trial-in-community-pharmacies-in-aotearoa-new-zealand
#28
JOURNAL ARTICLE
Gabrielle Shortt, Nicholas Shortt, Georgina Bird, Kyley Kerse, Nico Lieffering, Alexander Martin, Allie Eathorne, Bianca Black, Bob Kim, Marius Rademaker, Louise Reiche, Selwyn Te Paa, Suki Harding, Mike Armour, Alex Semprini
BACKGROUND: Eczema is a chronic, relapsing skin condition commonly managed by emollients and topical corticosteroids. Prevalence of use and demand for effective botanical therapies for eczema is high worldwide, however, clinical evidence of benefit is limited for many currently available botanical treatment options. Robustly-designed and adequately powered randomised controlled trials (RCTs) are essential to determine evidence of clinical benefit. This protocol describes an RCT that aims to investigate whether a mānuka oil based emollient cream, containing 2% ECMT-154, is a safe and effective topical treatment for moderate to severe eczema...
January 29, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38282883/prevalence-of-major-food-allergens-in-skincare-products-for-atopic-dermatitis
#29
JOURNAL ARTICLE
Klaudia Ryczaj, Magdalena Chojnowska-Wójtowicz, Karolina Dumycz, Wojciech Feleszko, Marek Kulus
INTRODUCTION: Food allergy is a common concomitant disease in patients with atopic dermatitis. Sensitisation and subsequent development of food allergy might result from the application of skincare products containing food allergens, particularly when the skin barrier is impaired and inflamed. Emollients are the mainstay of the management of atopic dermatitis; however, the prevalence of food allergens in skincare products used for atopic dermatitis is unknown. AIM: To analyse the prevalence of major food allergens in skincare products for atopic dermatitis...
December 2023: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38278753/updates-in-atopic-dermatitis-for-the-primary-care-physician-a-review-of-advances-in-the-understanding-and-treatment-of-atopic-dermatitis
#30
JOURNAL ARTICLE
Zi-Yi Choo, Stephanie L Mehlis, Joel C Joyce
Atopic dermatitis (AD) is a common inflammatory skin condition occurring in both pediatric and adult patients. Pruritus is a clinical hallmark of the disease, and patients with AD often experience disruptions to their quality of life. The pathogenesis of AD is a complex and multifactorial interplay between genetic factors, epidermal barrier disruption, and immune dysregulation. Clinically, AD is characterized by pruritus, eczematous skin changes, and age-specific lesion distribution patterns. Infants and young children tend to have AD lesions on their face and extensor surfaces of their extremities while older children and adults tend to have AD lesions on flexural surfaces of their extremities...
January 25, 2024: Disease-a-month: DM
https://read.qxmd.com/read/38253270/emollients-in-dermatological-creams-early-evaluation-for-tailoring-formulation-and-therapeutic-performance
#31
JOURNAL ARTICLE
M E Franco-Gil, A Graça, A Martins, J Marto, H M Ribeiro
The targeted choice of the emollient of a cream determines its physicochemical properties and clinical effectiveness. This work researched the effects of emollient properties on the final characteristics and potential performance of oil-in-water dermatological creams. Seven emollients with different chemical characteristics and structures (alkane, triglyceride, ether, silicone, vegetable oils, and mineral oil) were tested in a model formulation. Early stability, pH, droplet size distribution, rheology, tackiness, adhesivity, spreadability, tribology, and release profile of a lipophilic substance model (in Franz cells, through a synthetic membrane, for six hours) were assessed...
January 20, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38253125/skin-as-the-target-for-allergy-prevention-and-treatment
#32
REVIEW
Andreina Marques-Mejias, Irene Bartha, Christina E Ciaccio, R Sharon Chinthrajah, Susan Chan, Gurjit K Khurana Hershey, Jessica W Hui-Beckman, Laurie Kost, Gideon Lack, Janice A Layhadi, Donald Y M Leung, Hannah F Marshall, Kari C Nadeau, Suzana Radulovic, Reena Rajcoomar, Mohamed H Shamji, Sayantani Sindher, Helen A Brough
The fact that genetic and environmental factors could trigger disruption of the epithelial barrier and subsequently initiate a Th2 inflammatory cascade conversely proposes that protecting the same barrier and promoting adequate interactions with other organs, like the gut, may be crucial for lowering the risk and preventing atopic diseases particularly, food allergies. In this review, we provide an overview of structural characteristics that support the epithelial barrier hypothesis in AD patients, including the most relevant filaggrin gene mutations, the recent discovery of the role of the transient receptor potential vanilloid 1 (TRPV1), and the role involvement of the microbiome in healthy and damaged skin...
January 20, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38247728/supporting-children-young-people-and-families-to-self-manage-atopic-eczema
#33
JOURNAL ARTICLE
Emma Williams, Samantha Lakkiss
Atopic eczema is common in childhood and can continue into adulthood. Adherence to treatment is a significant factor in its effective management, but the complexity of treatment regimens can make adherence challenging. Additionally, living with the condition can have adverse psychosocial consequences for young people in particular. This article discusses treatment regimens for moderate-to-severe atopic eczema and some of the challenges encountered by children, young people and families in self-managing the condition...
January 22, 2024: Nursing Children and Young People
https://read.qxmd.com/read/38229798/intermittent-or-sequential-topical-tacrolimus-in-atopic-dermatitis-systematic-review-and-meta-analysis
#34
REVIEW
Sandipan Dhar, Abhishek De, Abhijit Saha, Kruttika R Chitnis, Abhishek Mane, Dhiraj Dhoot, Hanmant Barkate
Topical calcineurin inhibitors (TCIs) and topical corticosteroids (TCS) are the mainstays of flare management for atopic eczema or atopic dermatitis (AD). Tacrolimus (an immunomodulator), belongs to the class of calcineurin inhibitors, with promising efficacy in AD. We performed this systematic review to obtain an up-to-date coverage map of controlled clinical trials of sequential or intermittent treatments with TCI as a therapeutic intervention for AD. Articles of interest were retrieved from PubMed, Google Scholar, and EMBASE published between between January 2000 and March 2023...
December 2023: Curēus
https://read.qxmd.com/read/38226937/immunosuppressive-and-immunomodulating-therapy-for-atopic-dermatitis-in-pregnancy-an-appraisal-of-the-literature
#35
JOURNAL ARTICLE
Aska Drljevic-Nielsen, Sofine Heilskov, Mette S Deleuran, Christian Vestergaard
Atopic dermatitis (AD) is the most common dermatological diagnosis during pregnancy. Treatment of AD during pregnancy can be challenging, due to the unpredictable course and the fact that the therapy needs to be safe for both the mother and the fetus. Here we present an up-to-date appraisal of the literature on the treatment options available for AD in patients planning pregnancy, during pregnancy, and during breastfeeding. All patients with AD are recommended to supplement any medical treatment with daily applications of emollients...
January 16, 2024: Italian journal of dermatology and venereology
https://read.qxmd.com/read/38221777/adult-adolescent-and-caregiver-preferences-for-attributes-of-topical-treatments-for-mild-to-moderate-atopic-dermatitis-a-discrete-choice-experiment
#36
JOURNAL ARTICLE
Steven R Feldman, Jacob P Thyssen, Marco Boeri, Robert Gerber, Maureen P Neary, Amy Cha, Brett Hauber, Joseph C Cappelleri, Jason Xenakis, Colton Leach, Joshua Zeichner
Purpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative importance (CRI) of attributes of topical treatments for MM AD among adult and adolescent patients and caregivers of children with MM AD. Materials and methods: A discrete-choice experiment (DCE) survey was administered to US adults and adolescents with MM AD and caregivers of children with MM AD...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38214352/evaluation-of-the-benefit-of-the-addition-of-1-topical-luliconazole-versus-topical-bland-emollient-to-the-systemic-itraconazole-therapy-for-the-management-of-disseminated-dermatophytosis-a-randomised-control-trial
#37
JOURNAL ARTICLE
Deval K Rana, Tithi S Shah, Mansi H Rohit, Nayankumar H Patel, Avinash D Khadela, Yaksh P Oza, Jigna K Padhiyar
BACKGROUND: The present epidemic of dermatophytosis in India is marked by an increase in chronic, recurrent and disseminated cases. A combination of oral itraconazole and topical luliconazole is being increasingly utilised by dermatologists in India. The superiority of this combination is not supported by robust clinical trial data. OBJECTIVE: We conducted this randomised, open-label, two arms, parallel assignment intervention trial between November 2022 and May 2023 to determine the superiority of topical 1% Luliconazole over bland emollient as adjuvant to systemic Itraconazole therapy in the management of dermatophytosis...
January 2024: Mycoses
https://read.qxmd.com/read/38206153/evaluation-of-a-moisturizing-cream-with-20-urea-for-keratosis-pilaris
#38
JOURNAL ARTICLE
Erika McCormick, Dillon Nussbaum, Adam Friedman, Hanh Pham, Matthew H Meckfessel, Christine Emesiani
Keratosis pilaris (KP) is a benign dermatosis consisting of folliculocentric keratotic papules or pustules with surrounding erythema, often on proximal extensor surfaces of extremities. Management strategies for KP largely center on moisturization and exfoliation. Urea, a well-established ingredient in topical skincare, is a component of the natural moisturizing factors with concentration-dependent humectant, emollient, and exfoliative properties.  Given the overlap of urea’s properties and management goals of KP, a 4-week, open-label, noncomparative clinical study was conducted to evaluate a moisturizing cream formulated with 20% urea for use in KP...
January 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38196407/the-importance-of-p16-and-p53-immunohistochemical-staining-in-diagnosing-vulvar-lichen-simplex-chronicus-mimicking-vulvar-intraepithelial-neoplasia-with-false-positive-human-papillomavirus-type-66
#39
Pati Aji Achdiat, Muhamad Radyn Haryadi Widjaya, Rasmia Rowawi, Hermin Aminah Usman, Retno Hesty Maharani
Vulvar intraepithelial neoplasia (VIN), the precursor lesion of vulvar squamous cell carcinoma (VSCC), may present as pruritic or asymptomatic lichenified plaques surrounded by single or multiple discrete or confluent macules or papules. VIN is divided into high-grade squamous intraepithelial lesion (HSIL), which is human papillomavirus (HPV)-driven, and differentiated VIN (DVIN), which develops independently of HPV. Histopathological examination and HPV genotyping polymerase chain reaction (PCR) tests should be performed to distinguish between HSIL and DVIN...
2024: International Journal of Women's Health
https://read.qxmd.com/read/38175365/maintenance-of-an-acidic-skin-surface-with-a-novel-zinc-lactobionate-emollient-preparation-improves-skin-barrier-function-in-patients-with-atopic-dermatitis
#40
JOURNAL ARTICLE
Paul V Andrew, Abigail Pinnock, Anna Poyner, Kirsty Brown, John Chittock, Linda J Kay, Michael J Cork, Simon G Danby
INTRODUCTION: The skin of patients with atopic dermatitis (AD) is characterised by elevated pH. As a central homeostatic regulator, an increased pH accelerates desquamation and suppresses lipid processing, resulting in diminished skin barrier function. The aim of this study was to determine whether a novel zinc lactobionate emollient cream can strengthen the skin barrier by lowering skin surface pH. METHODS: A double-blind, forearm-controlled cohort study was undertaken in patients with AD...
January 4, 2024: Dermatology and Therapy
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