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https://www.readbyqxmd.com/read/29143926/prolonging-time-to-flare-in-pediatric-atopic-dermatitis-a-randomized-investigator-blinded-controlled-multicenter-clinical-study-of-a-ceramide-containing-moisturizer
#1
Lin Ma, Ping Li, Jianping Tang, Yifeng Guo, Chunping Shen, Jing Chang, Nabil Kerrouche
INTRODUCTION: Delaying or preventing flares is important in atopic dermatitis (AD) management. The objective of the study was to evaluate whether using a ceramide-containing moisturizer in addition to a body wash during latent AD can delay flares. METHODS: This was a randomized, investigator-blinded, parallel-group, controlled study among Chinese children with a history of mild to moderate AD, within 1 week of successful treatment with a topical corticosteroid...
November 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29134748/novel-topical-agent-containing-superoxide-dismutase-100%C3%A2-000%C3%A2-iu-and-4-of-plant-extracts-as-a-mono-therapy-for-atopic-dermatitis
#2
Dimitrios Sgouros, Alexander Katoulis, Dimitrios Rigopoulos
INTRODUCTION: Corticosteroids are the mainstay of treatment for the acute phase of atopic dermatitis (AD), whereas topical emollients are mainly used for maintenance of remission. A topical agent that combines emollient and anti-inflammatory properties would achieve control of all phases of AD, without the need for chronic corticosteroid use. AIM: To assess the efficacy of a novel topical agent containing superoxide dismutase (SOD) 100 000 IU and 4% of a combination of plant extracts (blackcurrant seed oil, sunflower oil concentrate, balloon vine extract)...
November 13, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29134613/dfd-01-reduces-transepidermal-water-loss-and-improves-skin-hydration-and-flexibility
#3
J Mark Jackson, Gary L Grove, Kent Allenby, Tim Houser
INTRODUCTION: In plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0.05%) is a formulation composed of a topical steroid in an emollient-like vehicle that enhances penetration to the target site of inflammation in the skin. The aim of this study was to assess the effect of DFD-01 and its vehicle on skin hydration and barrier function in compromised skin and to evaluate its effect on flexibility in healthy skin...
November 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29124712/safety-and-efficacy-of-phototherapy-in-the-management-of-eczema
#4
Annalisa Patrizi, Beatrice Raone, Giulia Maria Ravaioli
Atopic Dermatitis (AD), a common skin disease, can occur in patients of all age, gender and ethnicity. It is an inflammatory affection, characterized by chronic and highly debilitating behavior. First-line interventions against AD include environmental measures and topical emollients, corticosteroids or calcineurin inhibitors. When these measures are not sufficient, phototherapy represents an efficient second-line option of treatment; it can be administered on its own, or in the most severe cases combined with systemic medicaments such as corticosteroids...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29096848/immunoadsorption-for-treatment-of-severe-atopic-dermatitis
#5
Joanna Wegner, Julia Weinmann-Menke, Esther von Stebut
Atopic dermatitis (AD) is a common disease affecting up to 10-20% of the population with the largest disease burden in childhood. Treatment options include basic emollient treatment, topical as well as systemic immunosuppressants. The pathogenesis is complex and among various triggers, genetic predisposition and immunological alterations contribute to development of disease. Atopy is common in patients with AD and many patients have high levels of Immunoglobulin E (IgE), some of which recognizes exogenous or auto/self-allergens...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29064881/propylene-glycol-in-contact-dermatitis-a-systematic-review
#6
Maria A McGowan, Andrew Scheman, Sharon E Jacob
Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018. Contact, systemic, and irritant cutaneous reactions have been documented for PG, which has become an increasingly common ingredient. Propylene glycol is as contentious as it is ubiquitous because it acts as both a weak sensitizer and an irritant, confounding the results of positive patch tests...
October 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/29064431/release-behavior-and-antibacterial-activity-of-chitosan-alginate-blends-with-aloe-vera-and-silver-nanoparticles
#7
Luisa Fernanda Gómez Chabala, Claudia Elena Echeverri Cuartas, Martha Elena Londoño López
Aloe vera is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effects to integrate the antibacterial capacity of silver nanoparticles with the healing and emollient properties of Aloe vera gel...
October 24, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29063438/atopic-dermatitis-managing-the-itch
#8
William S Farmer, Kalyani S Marathe
Atopic dermatitis has a substantial impact on sleep, appearance, psychological well-being, and other qualities of life. The visual appearance of lichenification, cheilitis, hyperpigmentation, ichthyosis, and erythema can be socially stigmatizing, and treatment of these symptoms is challenging. In managing pruritus in patients, practitioners should assess and document pruritus through questionnaires at each routine visit. Initially, practitioners should advise patients to employ non-pharmaceutical treatments such as emollients with wet wraps, elimination of triggers, changing scratching habits, and psychological interventions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29063436/non-prescription-treatment-options
#9
Sandy François, Kayla Felix, Leah Cardwell, Taylor Edwards, Zakiya Rice
The pathogenesis of atopic dermatitis (AD) is complex and multifactorial. However, recent advancements in the genetics and pathophysiology of AD suggest that epidermal barrier dysfunction is paramount in the development and progression of the condition (Boguniewicz and Leung, Immunol Rev 242(1):233-246, 2011). In addition to standard therapy for AD, there are a plethora of non-prescription treatment modalities which may be employed. Over-the-counter treatments for atopic dermatitis can come in the form of topical corticosteroids, moisturizers/emollients, and oral anti-histamines...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29063435/prescription-treatment-options
#10
Brad Ackerson, Ryan Thorpe, Matilda W Nicholas
Atopic dermatitis frequently requires the use of over-the-counter and prescription medications for effective management. Emollients and topical corticosteroids are effective for most patients and are the most commonly utilized agents by experienced dermatologists. Antihistamines, antibiotics, and calcineurin inhibitors may also prove helpful in the correct clinical scenarios. Severe atopic dermatitis, however, can be difficult to manage and not infrequently require substantial immunomodulatory medications. Targeted molecular therapies, such as dupilumab, are promising, emerging atopic dermatitis therapies...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29061876/bet-1-does-the-use-of-emollients-prevent-frostbite-to-the-face
#11
Emmy De Buck
A short cut review was carried out to establish whether routine use of emollients on the face reduced the incidence of frostbite in cold environments. 126 papers were found using the reported searches, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that the use of emollients on the face is not a good protection against frostbite and may even result in a higher risk...
November 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29059092/allergen-of-the-year-propylene-glycol
#12
Sharon E Jacob, Andrew Scheman, Maria A McGowan
Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018. Allergic and irritant contact dermatitis and systemic cutaneous reactions to PG, which has become an increasingly common ingredient, have been documented. Propylene glycol is as contentious as it is ubiquitous because it acts as both a weak sensitizer and an irritant, confounding the results of positive patch tests...
November 10, 2017: Dermatitis
https://www.readbyqxmd.com/read/29055852/skin-care-for-healthy-babies-at-term-a-systematic-review-of-the-evidence
#13
REVIEW
Alison Cooke, Carol Bedwell, Malcolm Campbell, Linda McGowan, Steven J Ersser, Tina Lavender
OBJECTIVES: to identify what skin practices are important for the protection of baby skin in healthy term babies (0-6 months) and generate evidence-based conclusions to inform health professionals and parents. DESIGN: eleven databases were searched for all empirical quantitative and qualitative research published between 2000-2015 which explored baby skin care for bathing and cleansing, nappy care, hair and scalp care, management of dry skin or baby massage, for healthy term babies up to 6 months old...
October 6, 2017: Midwifery
https://www.readbyqxmd.com/read/29048238/superiority-of-a-vitamin-b12-containing-emollient-compared-to-a-standard-emollient-in-the-maintenance-treatment-of-mild-to-moderate-plaque-psoriasis
#14
Ester Del Duca, Francesca Farnetani, Nathalie De Carvalho, Ugo Bottoni, Giovanni Pellacani, Steven P Nisticò
Psoriasis is a chronic inflammatory skin disease affecting 2%-3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks...
October 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29042087/methyl-siloxanes-in-barbershops-and-residence-indoor-dust-and-the-implication-for-human-exposures
#15
Nannan Liu, Lin Xu, Yaqi Cai
Methyl siloxanes (MSs) have been widely added as emollients or solvents in various personal care products (PCPs) such as soap, shampoo and hair conditioner. A considerable percentage of MSs are released into the atmosphere directly from the use of PCPs in indoor environments. Indoor dust is a major reservoir of MSs, due to their particle-binding affinity. Dust ingestion could be one exposure pathway for special populations (hairdressers, for example). Though the toxicity of MSs is known, there is no information regarding the occurrence of MSs in barbershop dusts and the exposure of hairdressers through indoor dust ingestion...
October 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29020907/atopic-dermatitis-the-new-frontier
#16
REVIEW
Victoria R Harris, Alan J Cooper
Atopic dermatitis (AD) is the most common inflammatory skin condition in adults and children. AD is a chronic disease that has a considerable negative impact on the quality of life of patients and their families. Most cases of AD may be effectively treated with topical therapies that are directed at decreasing cutaneous inflammation and alleviating pruritus. These therapies include emollients, antihistamines, topical corticosteroids, topical calcineurin inhibitors and antimicrobial and antiseptic measures; more refractory cases may require additional oral immunosuppression (eg, cyclosporine, azathioprine, methotrexate and mycophenolate)...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28970453/knowledge-attitude-and-advice-giving-behaviour-of-community-pharmacists-regarding-topical-corticosteroids
#17
Wing Man Lau, Parastou Donyai
This study examines the relationship between community pharmacists' knowledge, attitudes to information provision and self-reported counselling behaviours in relation to topical corticosteroids and adjunct therapy in atopic eczema. A mixed-methods approach was used whereby data from interviews with community pharmacists were used to design a structured questionnaire that a larger sample of community pharmacists completed anonymously. The questionnaire was completed and returned by 105 pharmacists (36% response rate)...
July 25, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28940800/orofacial-granulomatosis-in-a-12-year-old-girl-successfully-treated-with-intravenous-pulse-corticosteroid-therapy-and-chloroquine
#18
Jovan Lalosevic, Mirjana Gajic-Veljic, Milos Nikolic
Orofacial granulomatosis, a rare disease in childhood, is characterized by orofacial swelling in the absence of systemic disease. We report the case of a 12-year-old girl with asymptomatic erythematous infiltration of her upper lip, cheeks, and chin that had persisted for more than 2 years; biopsy confirmed granuloma formation. Because a large area was affected, intralesional corticosteroids were inappropriate and six cycles of 3-day intravenous pulse corticosteroid therapy (dexamethasone 1.5mg/kg), repeated once after 4 weeks, was given...
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28940734/warming-up-to-the-idea-of-wet-wraps
#19
Chelsea A Cooper, Cynthia M C DeKlotz
Atopic dermatitis (AD) is a prevalent condition in the pediatric population that can have a significant effect on a child's quality of life. Management is multifactorial, involving topical pharmacotherapy, emollients, and a bathing regimen in conjunction with close supervision from the caregiver and physician. In the case of moderate to severe or refractory AD, wet wraps can be used. As part of our wet wrap regimen, we propose warming damp cotton pajamas in the dryer before application. This makes the wet wraps more comfortable for children, increasing adherence to the prescribed regimen...
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28940653/the-clinicoaetiological-hormonal-and-histopathological-characteristics-of-melasma-in-men
#20
S Handa, D De, G Khullar, B D Radotra, N Sachdeva
BACKGROUND: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings. AIM: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma. METHODS: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded...
September 22, 2017: Clinical and Experimental Dermatology
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