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Patent ductus arteriosus

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https://www.readbyqxmd.com/read/29243317/il-17-in-neonatal-health-and-disease
#1
Shelley M Lawrence, Jessica Lauren Ruoss, James L Wynn
Over the last few years, scientific interest in the cytokine IL-17A has intensified as its role in human health and disease has been elucidated. Discovered almost a quarter century ago, IL-17A is known to have poor biologic activity when acting alone, but attains robust actions when working synergistically with potent mediators of proinflammatory immune responses, such as IL-6 and IL-8. IL-17A is produced by specialized innate immune cells that protect host barriers from the outside world. Like sentries, these innate immune cells can "sound the alarm" through increased production of IL-17A, causing activation and recruitment of primed neutrophils and monocytes when pathogens escape initial host defenses...
December 15, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29242571/divergent-risk-factors-for-cerebellar-and-intraventricular-hemorrhage
#2
Zachary A Vesoulis, Maja Herco, Amit M Mathur
OBJECTIVE: To identify whether intraventricular hemorrhage (IVH) and cerebellar hemorrhage (CH) have common or divergent risk factors. STUDY DESIGN: This is a retrospective cross-sectional cohort of infants including all infants born <30 weeks from 2007 to 2016. Comprehensive perinatal and clinical factors were extracted from the medical record. Outborn infants, infants with major congenital anomaly, those transferred prior to discharge, and those with mixed or no brain injury were excluded...
December 15, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29242415/bronchopulmonary-dysplasia-in-preterm-neonates-in-a-level-iii-neonatal-unit-in-india
#3
Savita Bhunwal, Kanya Mukhopadhyay, Shalmoli Bhattacharya, Pranab Dey, Lakhbir Kaur Dhaliwal
OBJECTIVE: To find out the incidence and associations of bronchopulmonary dysplasia (BPD) in preterm neonates. DESIGN: Prospective, observational. METHODS: All consecutively born neonates <33 weeks gestation requiring oxygen or respiratory support first 3 days of life were enrolled from a level III neonatal unit in Chandigarh, India. Those with malformations were excluded. Placenta was examined for histological chorioamnionitis in preterm rupture of membranes and/or preterm spontaneous onset of labour...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29239259/oral-paracetamol-versus-oral-ibuprofen-for-treatment-of-patent-ductus-arteriosus
#4
Manar Al-Lawama, Iyad Alammori, Tariq Abdelghani, Eman Badran
Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29237020/extrinsic-compression-of-left-main-coronary-artery-by-aneurysmal-pulmonary-artery-in-severe-pulmonary-hypertension-its-correlates-clinical-impact-and-management-strategies
#5
Ozgur Yasar Akbal, Cihangir Kaymaz, Ibrahim Halil Tanboga, Aykun Hakgor, Fatih Yilmaz, Sevim Turkday, Cem Dogan, Seda Tanyeri, Durmus Demir, Zubeyde Bayram, Mahmut Bugrahan Cicek, Rezzan Deniz Acar, Nihal Ozdemir
Aims: Although left main coronary artery (LMCA) compression (Co) by pulmonary artery (PA) aneurysm (A) has been reported in some pulmonary hypertension (PH) series, clinical importance and management of this complication remain to be determined. In this single-centre prospective study, we evaluated correlates, clinical impact, and management strategies of LMCA-Co in patients with PH. Methods and results: Our study group comprised 269 (female 166, age 52.9 ± 17...
December 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29234596/exploring-the-multiple-hit-hypothesis-of-preterm-white-matter-damage-using-diffusion-mri
#6
Madeleine L Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A Kimpton, Nigel Kennea, Mary Rutherford, A David Edwards, Serena J Counsell
Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk factors. Our aim was to test this hypothesis in a large cohort of preterm infants using diffusion weighted magnetic resonance imaging (dMRI). Methods: We studied 491 infants (52% male) without focal destructive brain lesions born at < 34 weeks, who underwent structural and dMRI at a specialist Neonatal Imaging Centre...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29234148/quality-improvement-to-reduce-chronic-lung-disease-rates-in-very-low-birth-weight-infants-high-compliance-with-a-respiratory-care-bundle-in-a-small-nicu
#7
Zuzanna Kubicka, Eyad Zahr, Tamara Rousseau, Henry A Feldman, John Fiascone
OBJECTIVE: Reduce chronic lung disease by 10% among very-low birth weight infants by implementing a consistent respiratory care bundle. STUDY DESIGN: Prospective quality improvement study of infants below 32 weeks gestation in a small neonatal intensive care unit. A respiratory care bundle to eliminate inter-provider variability and minimize use of mechanical ventilation was implemented. This included: defining delivery room management with use of continuous positive airway pressure/nasal intermittent positive pressure ventilation, uniform intubation/extubation criteria, and standardizing ventilation/post-extubation support...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29233212/percutaneous-closure-of-a-large-patent-ductus-arteriosus-in-a-preterm-newborn-weighing-1400-g-without-using-arterial-sheath-an-innovative-technique
#8
Gaurav Garg, Vishal Garg, Amit Prakash
Percutaneous closure of patent ductus arteriosus is well established in infants weighing >5 kg, but data regarding outcome of preterm especially very low birth weight infants is minimal. Although surgical ligation of patent ductus arteriosus is the preferred and well-accepted modality of treatment after failure of drug therapy in preterm infants, it has also got its own demerits in such a small and fragile subset. Device closure in infants weighing <1.5 kg is rarely attempted because of high chances of complications, especially acute arterial injury due to the arterial sheath...
December 13, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29224772/resolution-of-vocal-fold-immobility-in-preterm-infants
#9
Jad Jabbour, Thomas Robey
INTRODUCTION: Vocal fold immobility (VFI) is an important sequela of preterm birth due to patent ductus arteriosus (PDA) ligation and invasive ventilation. A minority of these patients experience VFI resolution. The purpose of this study is to determine factors associated with VFI resolution in preterm infants. METHODS: This is a case control study of preterm (<37 weeks gestation) infants admitted to a metropolitan Level IV neonatal intensive care unit from 2006 to 2012...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29222766/electrical-velocimetry-for-non-invasive-monitoring-of-the-closure-of-the-ductus-arteriosus-in-preterm-infants
#10
Ana Rodríguez Sánchez de la Blanca, M Sánchez Luna, N González Pacheco, M Arriaga Redondo, N Navarro Patiño
Closure of a patent ductus arteriosus (PDA) in preterm infants modifies cardiac output and induces adaptive changes in the hemodynamic situation. The present study aims to analyze those changes, through a non-invasive cardiac output monitor based on blood electrical velocimetry, in preterm babies. A prospective observational study of preterm infants with a gestational age of less than 28 weeks, and a hemodynamic significant PDA, requires intravenous ibuprofen or surgical closure. All patients were monitored with electrical velocimetry before treatment and through the following 72 h...
December 8, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29214091/keeping-an-open-mind-cognitive-bias-in-the-evaluation-of-an-infant-with-posterior-lateral-rib-fractures
#11
Katie Johnson, Donald Chris Derauf, Raymond Stetson, Paul Galardy, Jason Homme
A four-month-old former premature male is incidentally found to have posterior-lateral rib fractures during evaluation of a febrile illness. This finding led to the initiation of a workup for nonaccidental trauma. A thorough history and physical exam ultimately led to the diagnosis, which was not related to abuse. This case highlights a rare sequela of patent ductus arteriosus repair, cautions medical teams to remain aware of how cognitive bias can affect diagnostic decision-making, and emphasizes the importance of a thorough history, physical exam, and medical record review in cases of suspected nonaccidental trauma...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29211219/incidence-and-treatment-of-chylothorax-in-children-undergoing-corrective-surgery-for-congenital-heart-diseases
#12
Nicolle Martin Christofe, Cristiane Felix Ximenes Pessotti, Laércio Paiva, Ieda Biscegli Jatene
INTRODUCTION: Chylothorax is a lymphatic extravasation into pleural cavity and its incidence is 0.25%-5.3% in children undergoing cardiac surgery. OBJECTIVE: To evaluate the incidence of chylothorax in pediatrics patients operated, linking it in each surgical intervention. Evaluate treatment types and efficiency. METHODS: Retrospective study using medical records of children undergoing cardiac surgery in the Hospital do Coração between 2004 and 2014...
September 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29203106/oral-pharmacological-treatment-for-patent-ductus-arteriosus-in-premature-neonates-with-hemodynamic-repercussions
#13
Clarissa de Albuquerque Botura, Bruno Ambrósio da Rocha, Thiely Balensiefer, Franciele Queiroz Ames, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
OBJECTIVE: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus (PDA) in premature neonates with significant clinical and hemodynamic repercussions (CHRs) and to determine the effect of these respective treatments on renal function. METHODS: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin [0...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29202750/assessment-of-tetralogy-of-fallot-associated-congenital-extracardiac-vascular-anomalies-in-pediatric-patients-using-low-dose-dual-source-computed-tomography
#14
Bi-Yue Hu, Ke Shi, Yu-Ping Deng, Kai-Yue Diao, Hua-Yan Xu, Rui Li, Zhi-Gang Yang, Ying-Kun Guo
BACKGROUND: To investigate the diagnostic value of dual-source computed tomography (DSCT) in the evaluation of tetralogy of Fallot (TOF)-associated extracardiac vascular abnormalities in pediatric patients compared with transthoracic echocardiography (TTE). METHODS: One hundred and twenty-three pediatric patients diagnosed with TOF were included in this retrospective study. All patients underwent DSCT and TTE preoperatively. All associated extracardiac vascular abnormalities and their percentages were recorded...
December 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29201998/treatment-and-outcome-for-children-with-esophageal-atresia-from-a-gender-perspective
#15
Julia Ekselius, Martin Salö, Einar Arnbjörnsson, Pernilla Stenström
Background: Besides the incidence of esophageal atresia (EA) being higher in males, no other gender-specific differences in EA have been reported. The aim of this study was to search for gender-specific differences in EA. Methods: A retrospective study was conducted at a tertiary center for pediatric surgery. The medical charts of infants born with EA were reviewed. 20 girls were identified, and 20 boys were selected as matched controls with respect to concomitant malformations...
2017: Surgery Research and Practice
https://www.readbyqxmd.com/read/29199861/stenting-the-complex-patent-ductus-arteriosus-in-tetralogy-of-fallot-with-pulmonary-atresia-challenges-and-outcomes
#16
Rizwan Rehman, Mood Che Marhisham, Mazeni Alwi
Patent ductus arteriosus (PDA) stenting has gained acceptance for palliation in cyanotic congenital heart disease. The PDA in tetralogy of Fallot with pulmonary atresia (ToF-PA) arises, in the left aortic arch, from underneath the arch and connects to the proximal left pulmonary artery, often resulting in stenosis. The PDA is usually elongated and tortuous, making stent implantation challenging. Shorter duration of palliation, aggravation of branch pulmonary artery stenosis resulting in poor growth and difficulty at surgery makes ductal stenting controversial...
December 4, 2017: Future Cardiology
https://www.readbyqxmd.com/read/29198223/ibuprofen-and-indomethacin-differentially-regulate-vascular-endothelial-growth-factor-and-its-receptors-in-ductus-arteriosus-endothelial-cells
#17
Hannes Sallmon, Sandra Akanbi, Sven C Weber, Alexander Gratopp, Cornelia Rheinländer, Petra Koehne
BACKGROUND: Cyclooxygenase inhibitors are widely applied to facilitate ductal closure in preterm infants. The mechanisms that lead to patent ductus arteriosus closure are incompletely understood. Vascular endothelial growth factor plays pivotal roles during ductal closure and remodelling. Aim The aim of this study was to investigate the effects of ibuprofen and indomethacin on the expression of vascular endothelial growth factor and its receptors in a primary rat ductus arteriosus endothelial cell culture...
December 4, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29193158/terlipressin-induced-modifications-of-doppler-ultrasound-signals-of-systemic-arteries-in-preterm-infants-with-vasoactive-resistant-patent-ductus-arteriosus-a-pilot-study
#18
M Radicioni, V Bini, G M Campus, P G Camerini
PURPOSE: To study the effects of terlipressin (TP) infusion on systemic perfusion, estimated with pulsed-wave Doppler ultrasonography of systemic arteries, in a population of extremely low birth-weight (ELBW) preterm infants with vasoactive-resistant ductus arteriosus. METHODS: This prospective, observational cohort included, during five years, 12 ELBW infants with hemodynamically significant patent ductus arteriosus and absent or reversed diastolic flow at Doppler ultrasonography of systemic arteries, despite treatment and high-dose vasoactive support...
November 28, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29184005/an-infant-with-congenital-rubella-syndrome-in-developing-india
#19
Ajit Singh, Sharon Narula, Hashir Kareem, Tom Devasia
Congenital rubella syndrome (CRS), caused by rubella virus infection during pregnancy, remains a public health concern in developing countries. Three to five per cent of all suspected CRS cases in India have been proven to be a rubella infection. Only about 45%-60% of pregnant women and infants in India receive the rubella vaccination. We present a case of a preterm female infant who tested positive for the rubella virus. The baby was born with low birth weight and, on examination, showed pallor and hepatosplenomegaly...
November 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29178522/direct-hyperbilirubinemia-in-infants-with-congenital-heart-disease
#20
Jun Fujishiro, Masahiko Sugiyama, Tetsuya Ishimaru, Miho Watanabe, Kaori Sato, Noriko Hoshino, Chizue Uotani, Mai Kutsukake, Yoichiro Hirata, Akira Oka
BACKGROUND: An association between congenital heart disease (CHD) and infantile cholestasis, a key finding for the diagnosis of biliary atresia (BA), remains unknown. The aim of this study was to investigate the characteristics of direct hyperbilirubinemia (D-HB) in infants with CHD. METHODS: All neonates who were admitted to our hospital and diagnosed with CHD in 2015 and 2016 were included. D-HB (direct bilirubin≧ 2.0 mg/dL) within 60 days of age and other clinical parameters were retrospectively reviewed...
November 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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