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https://www.readbyqxmd.com/read/29330848/cultured-allogeneic-fibroblast-injection-versus-fibroblasts-cultured-on-amniotic-membrane-scaffold-for-dystrophic-epidermolysis-bullosa-treatment
#1
H Moravvej, F Abdollahimajd, M-H Naseh, Z Piravar, E Abolhasani, N Mozafari, H Niknejad
BACKGROUND: Different methods of fibroblast application have been examined to treat recessive dystrophic epidermolysis bullosa (RDEB). OBJECTIVE: To compare the effects of intradermal injection of cultured allogeneic fibroblasts in healing RDEB wounds with that of fibroblasts seeded on amniotic membrane scaffolds (FAMS) or standard wound care (SWC) with Vaseline gauze as controls. MATERIALS &METHODS: Seven patients were recruited, and seven wounds were assessed in each patient: three wounds were treated with injection of intradermal fibroblasts, three were treated with FAMS, and one was dressed with SWC...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29322644/rosemary-castor-oils-and-propolis-extract-activity-against-candida-albicans-and-alterations-on-properties-of-dental-acrylic-resins
#2
Daiane Heidrich, Carmen Beatriz Borges Fortes, Aline Taís Mallmann, Clarissa Machado Vargas, Paula Borges Arndt, Maria Lúcia Scroferneker
PURPOSE: To evaluate the in vitro activity of 8% rosemary, 2% castor oils, and 12% propolis glycolic extract against Candida albicans, as well as the physical changes of properties in colorless and pink acrylic resins after immersion in these liquids. MATERIALS AND METHODS: Colorimetric, roughness, and Knoop microhardness assays were evaluated in 25 specimens distributed into five groups (3 test groups and 2 control groups - distilled water and hypochlorite 1%), totaling five specimens per group for each acrylic resin (colorless and pink)...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29320909/vascularization-of-lando%C3%A2-dermal-scaffold-in-an-acute-full-thickness-skin-defect-porcine-model
#3
Xuewen Qiu, Jiahan Wang, Guifang Wang, Huangdin Wen
The Lando® dermal scaffold is a newly developed, tissue-engineered dermal scaffold material. This study sought to observe its vascularization in an acute full-thickness skin-defect porcine model. There were eight Tibetan pigs in this research. Six 5 × 5 cm full-thickness skin-defect wounds were prepared on the dorsal area of each pig, which were divided into two groups. The experimental group wounds were covered by Lando® dermal scaffolds, while the other received Vaseline gauzes as blank control. At day 3, 7, 14 and 21 after injury, the general condition of wounds was observed, and wound specimens were obtained for HE staining, Masson staining and the expression of CD31, α-SMA and VEGF, which were examined by immunohistochemistry...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29279803/wound-healing-potential-of-oil-of-hypercium-perforatum-in-excision-wounds-of-male-sprague-dawley-rats
#4
Shivananada B Nayak, Kubra Isik, Julien R Marshall
Objective: To evaluate the wound-healing activity of oil of Hypercium perforatum (St. John's wort), in excision wounds of male white rats. Approach: The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Hyperforin and Hypericin are important phytochemical constituents found in H. perforatum, which have been highlighted for their antimicrobial, antiviral, and anti-inflammatory properties in recent times...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29083336/skin-graft-donor-site-a-procedure-for-a-faster-healing
#5
Roberto Cuomo, Luca Grimaldi, Cesare Brandi, Giuseppe Nisi, Carlo D'Aniello
BACKGROUND: The authors want to evaluate the efficacy of fibrillary tabotamp dressing in skin graft-donor site. A comparison was made with Vaseline gauzes. Tabotamp is an absorbable haemostatic product of Ethicon (Johnson and Johnson) obtained by sterile and oxidized regenerated cellulose (Rayon). It is used for mild to moderate bleeding. MATERIALS AND METHODS: 276 patients were subject to skin graft and divided into two group: Group A and Group B. The donor site of patients in Group A was medicated with fibrillary tabotamp, while the patients of Group B were medicated only with Vaseline gauze...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29077629/mechanism-of-action-of-topical-garlic-on-wound-healing
#6
Minhal Alhashim, Jamie Lombardo
BACKGROUND: Allicin, the active component of garlic, has been shown to have antimicrobial and anti-inflammatory properties. Garlic has also been used historically by many cultures to heal wounds. Several animal studies have shown that garlic extracts increase the rate of wound healing and decrease the rate of infection. OBJECTIVE: Fibroblasts play a key role in wound healing. Here we hypothesize that fibroblasts are being activated by allicin, leading to more organized and rapid wound repair...
October 26, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29071965/-inhibitory-effect-of-acupoint-application-on-airway-remodeling-and-expression-of-tgf-%C3%AE-1-smad-3-in-the-lung-tissue-of-chronic-asthma-mice
#7
Cheng-Yong Liu, Shan Qin, Lan-Ying Liu, Ya-Min He, He-Sheng Wang, Wen-Zhong Wu, Dong Chen, Cong Zhang
OBJECTIVE: To observe the effect of acupoint application on transforming growth factor (TGF)-β 1/Smad 3 signaling pathway, so as to reveal its mechanism underlying improvement of airway remodeling in chronic asthma mice. METHODS: BALB/c mice were randomly divided into normal group,model group,sham acupoint application group (sham group),acupoint application group, and dexamethasone group (n=8 in each group). The chronic asthma model was established by intraperitoneal injection of ovalbumin sensitization...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29019590/schinus-terebinthifolius-raddi-aroeira-leaves-oil-attenuates-inflammatory-responses-in-cutaneous-wound-healing-in-mice-1
#8
Lígia Reis Moura Estevão, Ricardo Santos Simões, Puebla Cassini-Vieira, Maria Cecilia Campos Canesso, Lucíola da Silva Barcelos, Milene Alvarenga Rachid, Cláudio Augusto Gomes da Câmara, Joaquim Evêncio-Neto
PURPOSE: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. METHODS: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO- treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28982338/thalidomide-improves-psoriasis-like-lesions-and-inhibits-cutaneous-vegf-expression-without-alteration-of-microvessel-density-in-imiquimod-induced-psoriatic-mouse-model
#9
Juan-Hua Liu, Hui-Hui Wu, Yu-Kun Zhao, Fang Wang, Qian Gao, Di-Qing Luo
Background Psoriasis is a chronic inflammatory skin disorder of unknown etiology. Increasing evidence suggests that psoriasis is probably an angiogenesis-dependent disease. Thalidomide has been reported being able to inhibit the effects of fibroblast growth factor 2 and vascular endothelial growth factor (VEGF), and inhibit tumour necrosis factor-alpha synthesis, and suppress tumour necrosis factor-induced nuclear factor-kappa B activation in Jurkat cells, resulting in suppression of proliferation inflammation, angiogenesis, and the immune system, which are related to the pathogenesis of psoriasis...
October 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28977118/effects-of-vacuum-sealing-drainage-on-the-treatment-of-cranial-bone-exposed-wounds-in-rabbits
#10
X J Chen, S Liu, G Z Gao, D X Yan, W S Jiang
This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2×2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0±0.65 kg). Animals were randomly divided into 4 groups: periosteum-intact wounds treated with traditional dressing (p+control), periosteum-intact wounds treated with VSD (p+VSD), periosteum-lacking wounds treated with traditional dressing (p-control) and periosteum-lacking wounds treated with VSD (p-VSD)...
October 2, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28938325/the-effect-of-dexpanthenol-vitamin-a-nazalnem-on-silastic-splints-after-nasal-septal-surgery
#11
Güven Yildirim, Tolgar Lütfi Kumral, Cem Altindağ, Erdi Özdemir, Yavuz Uyar
OBJECTIVE: To investigate the effect of dexpanthenol-vitamin A (Nazalnem) ointment applied to the surface of silastic splints with an airway immediately after nasal septal surgery on postoperative complaints and nasal mucosa function. MATERIALS AND METHODS: The study enrolled 60 patients undergoing nasal septoplasty surgery. Group 1 (n = 30) received silastic splints with ointment containing dexpanthenol-vitamin A (Nazalnem), and Group 2 (n = 30), the control group, received silastic splints with vaseline...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28926878/-effects-of-arnebia-root-oil-on-wound-healing-of-rats-with-full-thickness-skin-defect-and-the-related-mechanism
#12
J Y Shen, Q Ma, Z B Yang, J J Gong, Y S Wu
Objective: To observe the effects of arnebia root oil on wound healing of rats with full-thickness skin defect, and to explore the related mechanism. Methods: Eighty SD rats were divided into arnebia root oil group and control group according to the random number table, with 40 rats in each group, then full-thickness skin wounds with area of 3 cm×3 cm were inflicted on the back of each rat. Wounds of rats in arnebia root oil group and control group were treated with sterile medical gauze and bandage package infiltrated with arnebia root oil gauze or Vaseline gauze, respectively, with dressing change of once every two days...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28904977/misuse-of-topical-corticosteroids-for-cosmetic-purpose-in-antananarivo-madagascar
#13
F A Sendrasoa, I M Ranaivo, M Andrianarison, O Raharolahy, N H Razanakoto, L S Ramarozatovo, F Rapelanoro Rabenja
This cross-sectional study was conducted in Antananarivo, Madagascar, from June to September 2012. We aim to evaluate the misuse of TC on the face for cosmetic purpose and the adverse effects due to its application. A questionnaire-based analysis was done among females who use topical corticosteroids on the face for cosmetic purpose. Of the 770 women questioned, 384 (49,8%) used topical corticosteroids for cosmetic purpose whose mean age was 38 years (range 16-73 years). Two hundred and sixty-one females (68%) used TC combined with handcrafted cosmetics, and 123 (32%) used TC alone...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28888529/eyelid-inflammation-an-uncommon-cause-in-occidental-countries
#14
Hélène Devambez, Morgane Richeux, Maximilien Guericolas, Christophe Choquet, Enrique Casalino, Aiham Daniel Ghazali
BACKGROUND: Myiasis designates the infestation of live human and vertebrate animals with dipterous (two-winged) larvae (maggots) and is the fourth most common travel-associated skin disease. Furuncle is the most common aspect of cutaneous myiasis. CASE PRESENTATION: A 24-year-old Caucasian female had been back from Cap-Vert. She described pruritus, slight pain, and the sensation of a foreign body moving in the eyelid. Physical examination showed a single furuncle-like nodule with surrounding erythema and a central pore of the upper eyelid through which a serosanguinous fluid was exuding...
November 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28852444/heterologous-expression-of-a-truncated-form-of-human-recombinant-vascular-endothelial-growth-factor-a-and-its-biological-activity-in-wound-healing
#15
Mohsen Khaki, Ali Hatef Salmanian, Ghasem Mosayebi, Maryam Baazm, Saeed Babaei, Neda Molaee, Hamid Abtahi
OBJECTIVES: Vascular endothelial growth factor (VEGF) is one of the most effective proteins in angiogenesis, mesenchymal stem cells (MSCs) differentiation and wound healing. These abilities are therapeutic potential of VEGF in diabetic retinopathy, nephropathy and other tissue damage circumstances. In this study, recombinant VEGF was produced in Escherichia coli (E. coli) system and then biological activity of this protein was evaluated in animal wound healing. MATERIALS AND METHODS: E...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28816717/comparison-of-negative-pressure-wound-therapy-and-conventional-therapy-for-cranial-bone-exposed-wounds-in-rabbits
#16
Lin Chen, Guorui Li, Sha Liu, Xianjie Ma, Xueyong Li, Yingjun Su, Shuzhong Guo
BACKGROUND: Bone-exposed wounds with intact or defected periosteum are difficult to heal. To provide relevant experimental evidence for guidance of clinical therapy, we established a rabbit model to compare the efficacies of negative pressure wound therapy (NPWT) and conventional guaze dressing therapy on the healing of cranial bone-exposed wounds. METHODS: Full-thickness excisional circular wounds of 2.0 cm in diameter with exposed bones covered with or without periosteum were created at the parietal regions in 88 rabbits that were further randomly divided into the following treatment groups: periosteum-intact wounds treated with conventional vaseline gauze dressings (P + Control group), periosteum-intact wounds treated with NPWT (P + NPWT group), periosteum-lacking wounds treated with conventional vaseline gauze dressings (P-Control group), and periosteum-lacking wounds treated with NPWT (P-NPWT group)...
October 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28738899/a-rare-manifestation-of-burns-after-lightning-strike-in-rural-ghana-a-case-report
#17
Paschal Awingura Apanga, John Atigiba Azumah, Joseph Bayewala Yiranbon
BACKGROUND: Lightning is a natural phenomenon that mostly affects countries in the tropical and subtropical regions of the globe, including Ghana. Lightning strikes pose a global public health issue. Although strikes to humans are uncommon, it is associated with high morbidity and mortality. CASE PRESENTATION: We present a case of a 10-year-old Ghanaian girl who got second-degree burns after being struck by lightning. She was put on an intravenous broad-spectrum antibiotic (ceftriaxone), Ringer's lactate, and her burns were dressed with sterile gauze impregnated with Vaseline (petroleum jelly) and silver sulfadiazine ointment...
July 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28700086/antiseptics-for-burns
#18
REVIEW
Gill Norman, Janice Christie, Zhenmi Liu, Maggie J Westby, Jayne M Jefferies, Thomas Hudson, Jacky Edwards, Devi Prasad Mohapatra, Ibrahim A Hassan, Jo C Dumville
BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting...
July 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28698000/topical-diltiazem-ointment-in-post-hemorrhoidectomy-pain-relief-a-meta-analysis-of-randomized-controlled-trials
#19
Yan-Jiun Huang, Chien-Yu Chen, Ray-Jade Chen, Yi-No Kang, Po-Li Wei
BACKGROUND: Hemorrhoidectomy is commonly associated with postoperative pain. Calcium channel blockers are known to cause relaxation of gastrointestinal smooth muscle and oral diltiazem has also been shown to reduce the resting anal pressure. OBJECTIVE: We attempted to analyze efficacy and side effects of topical diltiazem oint. in post-operative pain control. METHODS: This is a meta-analysis of patients who underwent hemorrhoidectomy using topical diltiazem oint...
July 8, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28662298/advanced-film-forming-gel-formula-vs-spring-thermal-water-and-white-petrolatum-as-primary-dressings-after-full-face-ablative-fractional-co2-laser-resurfacing-a-comparative-split-face-pilot-study
#20
Leonardo Marini
BACKGROUND: Aesthetically pleasing results and fast, uneventful recovery are highly desirable after rejuvenating ablative laser procedures. Wound dressings following ablative laser procedures should ideally improve and optimize the wound healing environment. OBJECTIVE: The purpose of this comparative split face, single blinded, prospective observational study was to assess the efficacy and acceptability of two primary wound dressings immediately after a full face fractional CO2 laser resurfacing procedure...
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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