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https://www.readbyqxmd.com/read/28522399/anti-allergic-and-profilaggrin-proflg-mrna-expression-modulatory-effects-of-sacran
#1
Nlandu R Ngatu, Keiichi Motoyama, Yasumitsu Nishimura, Maiko Kaneko Okajima, Ryoji Hirota, Taishi Higashi, Suni Lee, Hidetoshi Arima, Mitsunori Ikeda, Sayumi Nojima, Tatsuo Kaneko
Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0.2% and 1%sacran; 0.1% Tacrolimus; Vaseline and buffer-treated controls. Blood samples were drawn and serum levels of representative Th-1, Th-2 and also Th-17 (IL-17A) cytokines were assayed by Cytometric Bead Array (CBA)...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28522073/cell-based-skin-substitutes-accelerate-regeneration-of-extensive-burn-wounds-in-rats
#2
Sadrollah Motamed, Ehsan Taghiabadi, Hojjat Molaei, Niloofar Sodeifi, Seyed Esmaeil Hassanpour, Saeed Shafieyan, Enzollah Azargashb, Fatemeh Farajzadeh-Vajari, Nasser Aghdami, Amir Bajouri
BACKGROUND: This study investigated the effects of amniotic membrane combined with adipose-derived stem cells or fetal fibroblasts on regenerating extensive burns in rats. METHODS: Third degree burns of 1100-1800 mm(2) were induced on 32 Sprague-Dawley rats. Burned sites were excised and randomly covered with Vaseline gauze (control), human amniotic membrane (HAM), human fetal fibroblasts seeded on HAM (HAM-FF), or human adipose-derived stem cells seeded on HAM (HAM-ASC), and followed by wound closure and histological assessments...
April 27, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28480439/evaluation-of-crude-flaxseed-linum-usitatissimum-l-oil-in-burn-wound-healing-in-new-zealand-rabbits
#3
Katiba Beroual, Amir Agabou, Mohamed-Cherif Abdeldjelil, Naima Boutaghane, Saîd Haouam, Youcef Hamdi-Pacha
BACKGROUND: Burns are among the most prevalent injuries in humans with high cost in health care and heavy prolonged or permanent physical, psychological and social consequences. Commercial antimicrobial creams and dressing agents are unsuccessful in healing deep burn wounds. MATERIALS AND METHODS: A study was conducted to assess the impact of crude linseed oil (LSO) topical application on burn wounds healing in rabbits in comparison with untreated wounds (NAT) and those treated with Vaseline gel (VAG) and Cicatryl-Bio ointment (CBO)...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28415466/effect-of-lubricant-on-the-reliability-of-dental-implant-abutment-screw-joint-an-in-vitro-laboratory-and-three-dimension-finite-element-analysis
#4
Tingting Wu, Hongyi Fan, Ruiyang Ma, Hongyu Chen, Zhi Li, Haiyang Yu
Biomechanical factors play a key role in the success of dental implants. Fracture and loosening of abutment screws are major issues. This study investigated the effect of lubricants on the stability of dental implant-abutment connection. As lubricants, graphite and vaseline were coated on the abutment screw surface, respectively, and a blank without lubricant served as the control. The total friction coefficient (μtot), clamping force, fatigue behavior and detorque of the joint combined with dynamic cyclic loading were measured under different lubricating conditions...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28400845/wound-healing-effects-of-prunus-yedoensis-matsumura-bark-in-scalded-rats
#5
Jin-Ho Lee, Kyungjin Lee, Mi-Hwa Lee, Bumjung Kim, Khanita Suman Chinannai, Heseung Hur, Inhye Ham, Ho-Young Choi
Pruni Cortex has been used to treat asthma, measles, cough, urticaria, pruritus, and dermatitis in traditional Korean medicine. The objective of this study was to investigate the effects of Prunus yedoensis Matsumura bark methanol extract (PYE) on scald-induced dorsal skin wounds in rats. Scalds were produced in Sprague-Dawley rats with 100°C water and treated with 5% and 20% PYE (using Vaseline as a base), silver sulfadiazine (SSD), and Vaseline once a day for 21 days, beginning 24 hours after scald by treatment group allocation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28326861/cutaneous-applied-nano-zno-reduce-the-ability-of-hair-follicle-stem-cells-to-differentiate
#6
Wei Ge, Yong Zhao, Fang-Nong Lai, Jing-Cai Liu, Yuan-Chao Sun, Jun-Jie Wang, Shun-Feng Cheng, Xi-Feng Zhang, Li-Lan Sun, Lan Li, Paul W Dyce, Wei Shen
The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0...
March 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28203322/congenital-ichthyosis-a-case-treated-successfully-with-acitretin
#7
Selvi Gulasi
INTRODUCTION: Lamellar ichthyosis (collodion baby) is a cornification disorder classified under the category of autosomal recessive congenital ichthyosis and characterized by hyperkeratosis. Early-stage retinoid treatment has been shown to improve survival in these patients. In this article, a lamellar ichthyosis case is presented of an infant who had the symptoms at birth and was treated successfully with acitretin. CASE PRESENTATION: A term newborn infant presented after delivery...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28096316/bay-11-7082-inhibits-the-nf-kb-and-nlrp3-inflammasome-pathways-and-protects-against-imq-induced-psoriasis
#8
Natasha Irrera, Mario Vaccaro, Alessandra Bitto, Giovanni Pallio, Gabriele Pizzino, Maria Lentini, Vincenzo Arcoraci, Letteria Minutoli, Michele Scuruchi, Giuseppina Cutroneo, Giuseppe Pio Anastasi, Roberta Ettari, Francesco Squadrito, Domenica Altavilla
BAY 11-7082 antagonizes I-κB kinase-β preventing nuclear translocation of NF-κB; it also inhibits NLRP3 inflammasome activation.NF-κB is involved in psoriasis, while the role of NLRP3 is controversial. We investigated BAY 11-7082 effects in an experimental model of psoriasis-like dermatitis. Psoriasis-like lesions were induced by a topical application of imiquimod cream (IMQ; 62.5 mg/day) on the shaved back skin of C57BL/6 and NLRP3 knock-out mice for 7 consecutive days. Sham psoriasis animals were challenged with vaseline cream...
January 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28078772/skin-cleansing-and-emolliating-for-older-people-a-quasi-experimental-pilot-study
#9
Jill Brooks, Fiona Cowdell, Steven J Ersser, Eric D Gardiner
AIMS: The aims of this study were to (i) assess the effect of low-cost hygiene and emollient regimens on the skin barrier function (SBF) of people aged >65 year with xerosis (dry skin) on their lower legs; (ii) to assess the utility of portable measures of skin barrier function in terms of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in community settings; and iii) to provide evidence for a randomised controlled trial on the treatment of adults in a resource-poor country with dry skin on their lower legs which causes and exacerbates the skin disease podoconiosis (non-filarial elephantiasis)...
January 12, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28069324/differences-in-therapeutic-effects-of-topically-applied-corticosteroid-and-tacrolimus-on-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#10
Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Kyi Chan Ko, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
BACKGROUND: Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. OBJECTIVE: This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms...
April 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28040363/wound-healing-promoting-effect-of-total-tannins-from-entada-phaseoloides-l-merr-in-rats
#11
Xiaowen Su, Xinguang Liu, Shouyu Wang, Bin Li, Taowen Pan, Dingrui Liu, Fei Wang, Yunpeng Diao, Kun Li
The healing of wounds has always provided challenges for the medical community whether chronic or acute. Modern and traditional medicine has proved that herbal medicine shown superiority over chemical drugs. Herein, we report an Entada phaseoloides (L.) Merr. extract with a total tannin content of 76.18% showed wound-healing promoting effect in rat model. We found significantly accelerated wound closure already on day 7 in animals treated with total Entada phaseoloides (L.) Merr. tannins (TEPT) as compared to vaseline treated controls (p<0...
December 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28006800/a-simple-and-quick-method-of-displaying-liquid-preserved-morphological-structures-for-microphotography
#12
You Ning Su
Stabilising microstructures and small organisms for microphotography can be frustrating. If it is desired to take photographs in water from structures just cleared in potassium hydroxide, some sort of stabilisation is necessary otherwise the structures drift. Similarly, specimens taken from glycerol or alcohol, or those placed in alcohol, drift even more as the alcohol evaporates. Bits of crushed coverslip, glass beads, micro pins and dobs of Vaseline® have all been used to help keep the structures in place...
December 21, 2016: Zootaxa
https://www.readbyqxmd.com/read/27894387/-effect-of-hydrocinnamoyl-l-valyl-pyrrolidine-on-healing-quality-of-deep-partial-thickness-scald-wound-in-mice
#13
M L Yang, Y H Li, Q Tan, J T Li, L L Que
Objective: To observe the effect of Toll interleukin-1 recptor homology/BB-loop mimetic hydrocinnamoyl-L-valyl pyrrolidine (AS-1) on the healing quality of deep partial-thickness scald wound in mice. Methods: Forty-two adult C57BL/6 mice were divided into sham injury group (SI), scald group (S), early AS-1 treatment group (EAT), early dimethyl sulfoxide (DMSO) control group (EDC), late AS-1 treatment group (LAT), late DMSO control group (LDC) according to the random number table, with 7 mice in each group. Mice in group SI were sham injured without other treatment...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27876906/topical-terbinafine-in-the-treatment-of-cutaneous-leishmaniasis-triple-blind-randomized-clinical-trial
#14
Saeedeh Farajzadeh, Amireh Heshmatkhah, Behrooz Vares, Elham Mohebbi, Azadeh Mohebbi, Mahin Aflatoonian, Sana Eybpoosh, Iraj Sharifi, Mohammad Reza Aflatoonian, Simin Shamsi Meymandi, Ali Reza Fekri, Mahshid Mostafavi
Leishmaniasis is a spectrum of disease condition with considerable health impacts, caused by different species of Leishmania. This disease is currently endemic in 98 countries and territories in the world. There are many treatment modalities for cutaneous leishmaniasis. The use of topical terbinafine in the treatment of cutaneous leishmaniasis has recently been considered. Eighty-eight participants more than two years old with proven acute CL by a positive direct smear were randomly allocated to one of the two study arms: first group received meglumine antimoniate (Glucantime) 20 mg/kg/day intramuscular injection (IM) plus a placebo ointment (Mahan Vaseline) for 20 days...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#15
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27817210/evaluation-of-a-new-topical-skin-protectant-rd1433-for-the-prevention-and-treatment-of-incontinence-associated-dermatitis
#16
Hazem Matar, Joanne Larner, Vanessa Viegas, Sneha Kansagra, Karen L Atkinson, Satyajit Shetage, John T Skamarauskas, Baveetharan Theivendran, Virginia S Goldman, Robert P Chilcott
CONTEXT: Incontinence-associated dermatitis (IAD) is a type of moisture-associated dermatitis caused by repeated skin exposure to urine or stool. A product that could mitigate such symptoms would have a significant impact on cost of care and patients' quality of life. OBJECTIVE: This study compared the clinical efficacy of RD1433 and a comparator product (Vaseline®) in preventing and treating experimental IAD skin lesions. MATERIALS AND METHODS: For the "prevention" part of the study, skin sites in eight human volunteers were treated daily for five days with either RD1433 or Vaseline® immediately prior to synthetic urine exposure...
November 6, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27795221/-acute-generalized-exanthematous-pustulosis-induced-by-piroxicam
#17
Ingrid Bissinger, Gustavo Matute-Turizo, María Natalia Mejía-Barreneche
BACKGROUND: Between 62 and 90% of cases of acute generalized exanthematous pustulosis are caused by drugs. Its onset is rapid with generalized pustules, fever, and blood neutrophil count over 7000; pustules resolve spontaneously in less than 15 days. A case associated with piroxicam described. CASE REPORT: A 36-year-old with initial erythema of the thorax and abdomen, accompanied by burning, without fever, which later spread to his forearms, upper arms, and thighs, with face edema...
October 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27781111/comparison-of-hydrogel-produced-by-radiation-as-applied-at-the-research-center-yazd-branch-with-maxgel-and-routine-dressing-for-second-degree-burn-repair-in-yazd-burn-hospital
#18
Mohammad Taghi Noorbala, Mohammad Noorbala, Mohammad Hossein Dashti-Rahmatabadi, Mahdi Noorbala, Roghaye Noorbala, Behare Mozaffary
BACKGROUND: Recently, the radiation application research center for the atomic energy organization of Yazd (Iran) has developed a hydrogel dressing which was evaluated for quality and safety in 2008. Its efficacy for assisting in the wound healing process was approved for animal use, and its use has proven to be more effective than a related Syrian material. OBJECTIVES: We have already confirmed the safety and efficacy of Irgel use on mice (1, 2), so this study was conducted in order to further evaluate its effectiveness on human burn wounds, and to compare its efficacy with MaxGel, another hydrogel...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27716154/effect-of-the-herbal-mixture-composed-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrha-on-wound-healing-in-streptozotocin-induced-diabetic-rats
#19
Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals...
October 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27706396/wound-healing-potential-of-sebastiania-hispida-mart-pax-euphorbiaceae-ointment-compared-to-low-power-laser-in-rats
#20
E S Rizzi, D M Dourado, R Matias, J A I Muller, J F Guilhermino, A T G Guerrero, D L Moreira, B A K Silva, M Barbosa-Ferreira
Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia...
October 3, 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
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