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https://www.readbyqxmd.com/read/29768078/wet-wrap-therapy-with-halometasone-cream-for-severe-adult-atopic-dermatitis
#1
Wei Xu, Yan Li, Zeyu Chen, Teng Liu, Shan Wang, Linfeng Li
BACKGROUND: Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient. METHODS: Twelve patients (8 men and 4 women) with severe AD (SCORing Atopic Dermatitis [SCORAD] score≥50) treated between January 2015 and September 2017 in our hospital were included. The patients underwent WWT (daily dose: 15g halometasone cream+100g Vaseline ointment) twice daily for 2 hours/session for 7 days...
May 16, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29747248/-experience-of-successful-rescue-from-5-cases-of-internal-carotid-artery-injury-during-transnasal-endoscopic-skull-base-surgery
#2
F Yin, J W Sun, Y F Wang, T Guo, W Zhao
Objective: To investigate the cause and urgent management of internal carotid artery injury during transnasal endoscopic skull base surgery. Methods: Five cases of internal carotid artery injury encountered during transnasal endoscopic skull base surgery in Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of University of Science of Technology of China, Anhui Provincial Hospital from December 2010 to July 2017 were analysed retrospectively. There were 2 cases of adenoid cystic carcinoma, 1 case of salivary gland-type adenocarcinoma, 1 case of petrous apex cholesterol granulomas and 1 case of squamous carcinoma...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29723852/flexural-strength-of-glass-carbomer-cement-and-conventional-glass-ionomer-cement-stored-in-different-storage-media-over-time
#3
Muhammad Ali Faridi, Abdul Khabeer, Saad Haroon
OBJECTIVES: Glass Ionomer Cement (GIC) is routinely placed as a restorative material in dentistry. However, due to its poor physical properties, its use is limited to cases where the level of stress on the restoration is minimal. Improved formulations of GIC have been developed to overcome these drawbacks. The purpose of the study was to evaluate the flexural strength of a conventional GIC (Fuji IX) against the newly developed Glass Carbomer Cement (GCP). MATERIALS AND METHODS: A total of 80 blocks for Fuji IX and GCP were prepared and divided into 16 groups (n = 5)...
May 3, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29719840/local-xenotransplantation-of-bone-marrow-derived-mast-cells-bmmcs-improves-functional-recovery-of-transected-sciatic-nerve-in-cat-a-novel-approach-in-cell-therapy
#4
Rahim Mohammadi, Dana Anousheh, Mohammad-Hazhir Alaei, Amin Nikpasand, Hawdam Rostami, Rasoul Shahrooz
Objective: To determine the effects of bone marrow derived mast cells (BMMCs) on functional recovery of transected sciatic nerve in animal model of cat. Method: A 20-mm sciatic nerve defect was bridged using a silicone nerve guide filled with BMMCs in BMMC group. In Sham-surgery group (SHAM), the sciatic nerve was only exposed and manipulated. In control group (SILOCONE) the gap was repaired with a silicone nerve guide and both ends were sealed using sterile Vaseline to avoid leakage and the nerve guide was filled with 100 μL of phosphate-buffered saline alone...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29718810/comparison-of-dna-damage-and-apoptosis-induced-by-silver-nanoparticle-containing-dressing-materials-during-wound-healing
#5
Young Suk Choi, Heui-Chul Gwak, Jae Keun Park, Ji Yun Lim, Eui Dong Yeo, Eunseok Park, Junyong Kim, Young Koo Lee
INTRODUCTION: Silver nanoparticle (AgNP)-containing dressings are used worldwide for the treatment of wounds; however, many studies have indicated that AgNPs are toxic to humans and cause cell death, primarily via apoptosis. OBJECTIVE: In this study, the investigators compare the apoptotic effects of various AgNP dressing materials, with the hypothesis that nanosilver would be less toxic than ionic silver. MATERIALS AND METHODS: For the in vivo experiments, Sprague-Dawley (SD) and streptozotocin (STZ)-induced diabetic rats were treated with 5 dressing materials: Aquacel Ag (product A, silver ion; ConvaTec, Berkshire, UK), Acticoat (product B, AgNP; Smith & Nephew, Fort Worth, TX), Medifoam Silver (product C, silver ion; Genewel Science Co Ltd, Seongnam, South Korea), PolyMem Silver (product D, AgNP; Ferris Mfg Corp, Fort Worth, TX), and Vaseline-impregnated dressing gauze (control; Unilever, London, UK)...
April 13, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29665712/nocardia-rubra-cell-wall-skeleton-accelerates-cutaneous-wound-healing-by-enhancing-macrophage-activation-and-angiogenesis
#6
Yi Wang, Ying Hu, Ben Ma, Fei Wang, Sheng Liu, Jing Xu, Xu-Lin Chen, Xiong-Wen Lü
Objective This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. Methods Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29651394/the-healing-effect-of-sesame-oil-camphor-and-honey-on-second-degree-burn-wounds-in-rat
#7
Reza Vaghardoost, Seyed GholamReza Mousavi Majd, Hamid Tebyanian, Hamid Babavalian, Leila Malaei, Mitra Niazi, Ali Javdani
BACKGROUND: Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline. METHODS: Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649320/strychnos-pseudoquina-modulates-the-morphological-reorganization-of-the-scar-tissue-of-second-intention-cutaneous-wounds-in-rats
#8
Mariáurea Matias Sarandy, Lyvia Lopes Miranda, Luciana Schulthais Altoé, Rômulo Dias Novaes, Virgínia Vinha Zanuncio, João Paulo Viana Leite, Reggiani Vilela Gonçalves
Natural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no...
2018: PloS One
https://www.readbyqxmd.com/read/29643046/-efficacy-of-dermal-scaffold-for-promoting-repair-of-acute-full-thickness-skin-defects-in-pigs
#9
Xue-Wen Qiu, Jia-Han Wang
OBJECTIVE: To investigate the efficacy of Lando® dermal scaffold for promoting repair of acute full-thickness skin defects in pigs and explore the possible mechanism. METHODS: Three 5 cm×5 cm full-thickness skin defects were created on the left dorsal skin (control group) and another 3 on the right dorsal skin (treatment group) of each of 6 Tibetan pigs. The wounds in the treatment group were covered with a bilayer artificial skin (Lando) and the control wounds with vaseline gauze...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29575942/effects-of-plantago-lanceolata-l-extract-on-full-thickness-excisional-wound-healing-in-a-mouse-model
#10
B Kurt, N Bilge, M Sözmen, U Aydın, T Önyay, I Özaydın
Wound healing requires cells that increase both collagen production as a result of inflammatory events and regeneration of epithelial tissue. The Plantago species of herbs have been used in traditional treatment of skin disorders and infectious diseases, and digestive, respiratory, reproductive and circulatory conditions. We investigated the efficacy of different concentrations of Plantago lanceolata L. extract (PLE) for wound healing owing to its anti-inflammatory, anti-bacterial, anti-fungal, anti-oxidant, anti-ulcerative, analgesic and immunomodulatory properties...
March 26, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29500077/protective-role-of-6-formylindolo-3-2-b-carbazole-ficz-an-endogenous-ligand-for-arylhydrocarbon-receptor-in-chronic-mite-induced-dermatitis
#11
Mari Kiyomatsu-Oda, Hiroshi Uchi, Saori Morino-Koga, Masutaka Furue
BACKGROUND: Chronic eczema such as atopic dermatitis imposes significant socio-econo-psychologic burdens on the affected individuals. In addition to conventional topical treatments, phototherapy is recommended for patients with extensive lesions. Although immunosuppression is believed to explain its primary effectiveness, the underlying mechanisms of phototherapy remain unsolved. Ultraviolet irradiation generates various tryptophan photoproducts including 6-formylindolo[3,2-b]-carbazole (FICZ)...
June 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29491655/follicular-unit-grafting-in-chronic-nonhealing-leg-ulcers-a-clinical-study
#12
Leelavathy Budamakuntla, Eswari Loganathan, Sacchidananda A Sarvajnamurthy, H V Nataraj
Introduction and Objectives: The restoration of the epithelium after injury takes place by migration of epithelial cells adjoining a wound or by centrifugal migration from hair follicles. To evaluate the feasibility and potential healing capacity of scalp follicular unit grafts transplanted into the wound bed of chronic leg ulcers. Materials and Methods: Patients with chronic nonhealing ulcers of more than 6 weeks duration were selected for the study. Those with infected ulcers and uncontrolled diabetes were excluded from the study...
October 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29476878/low-systemic-exposure-and-calcemic-effect-of-calcipotriol-betamethasone-ointment-in-rats-with-imiquimod-induced-psoriasis-like-dermatitis
#13
Kyosuke Satake, Toru Amano, Tadao Okamoto
Vitamin D3 (VD3 ) analogues-containing ointments are known to occasionally cause hypercalcemia in psoriasis patients, and the frequency of hypercalcemia is suggested to vary based on the VD3 analogue used. In this study, to address the differences in calcemic effects of VD3 -containing ointments, the calcemic effects of marketed VD3 -containing ointments, including calcipotriol (Cal), maxacalcitol (Max), tacalcitol (Tac), calcipotriol/betamethasone dipropionate (Cal/BDP) and maxacalcitol/betamethasone butyrate propionate (Max/BBP) ointments, were evaluated in a rat model of imiquimod-induced dermatitis...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29464980/evaluation-the-efficacy-of-trichloroacetic-acid-tca-33-in-treatment-of-oral-retinoid-induced-cheilitis-compared-with-placebo-vaseline-a-randomized-pilot-study
#14
Parvin Mansouri, Zahra Azizian, Somayeh Hejazi, Reza Chalangari, Katalin Martits Chalangari
BACKGROUND: Oral Isotretinoin (13-cis-retinoic acid) is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication. We designed this novel study to investigate the therapeutic effect of trichloroacetic acid (TCA) 33% as compared with placebo to treat cheilitis. METHODS: In this pilot study, 90 acne vulgaris patients between 18 and 50 years, who referred dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015 with data analysis in 2016...
March 6, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29372039/monitoring-wound-healing-of-burn-in-rat-model-using-human-wharton-s-jelly-mesenchymal-stem-cells-containing-cgfp-integrated-by-lentiviral-vectors
#15
Mohammad Reza Pourfath, Abbas Behzad-Behbahani, Seyedeh Sara Hashemi, Amin Derakhsahnfar, Mohammad Naser Taheri, Saeede Salehi
Objectives: Human Wharton's Jelly mesenchymal stem cells (hWMSCs) are undifferentiated cells commonly used in regenerative medicine. The aim of this study was to develop a reliable tool for tracking hWMSCs when utilized as therapeutics in burnt disorders and also to optimize the cell-based treatment procedure. Materials and Methods: The hWMSCs were first isolated from fresh umbilical cord Wharton's jelly and cultured. The 293LTV cell line was transfected by cGFP containing lentiviral vector and the helper plasmids for production of the viral particle...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29330848/cultured-allogeneic-fibroblast-injection-versus-fibroblasts-cultured-on-amniotic-membrane-scaffold-for-dystrophic-epidermolysis-bullosa-treatment
#16
H Moravvej, F Abdollahimajd, M-H Naseh, Z Piravar, E Abolhasani, N Mozafari, H Niknejad
BACKGROUND: Different methods of fibroblast application have been examined to treat recessive dystrophic epidermolysis bullosa (RDEB). OBJECTIVE: To compare the effects of intradermal injection of cultured allogeneic fibroblasts in healing RDEB wounds with that of fibroblasts seeded on amniotic membrane scaffolds (FAMS) or standard wound care (SWC) with Vaseline gauze as controls. MATERIALS &METHODS: Seven patients were recruited, and seven wounds were assessed in each patient: three wounds were treated with injection of intradermal fibroblasts, three were treated with FAMS, and one was dressed with SWC...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29322644/rosemary-castor-oils-and-propolis-extract-activity-against-candida-albicans-and-alterations-on-properties-of-dental-acrylic-resins
#17
Daiane Heidrich, Carmen Beatriz Borges Fortes, Aline Taís Mallmann, Clarissa Machado Vargas, Paula Borges Arndt, Maria Lúcia Scroferneker
PURPOSE: To evaluate the in vitro activity of 8% rosemary, 2% castor oils, and 12% propolis glycolic extract against Candida albicans, as well as the physical changes of properties in colorless and pink acrylic resins after immersion in these liquids. MATERIALS AND METHODS: Colorimetric, roughness, and Knoop microhardness assays were evaluated in 25 specimens distributed into five groups (3 test groups and 2 control groups - distilled water and hypochlorite 1%), totaling five specimens per group for each acrylic resin (colorless and pink)...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29320909/vascularization-of-lando-%C3%A2-dermal-scaffold-in-an-acute-full-thickness-skin-defect-porcine-model
#18
Xuewen Qiu, Jiahan Wang, Guifang Wang, Huangdin Wen
The Lando® dermal scaffold is a newly developed, tissue-engineered dermal scaffold material. This study sought to observe its vascularization in an acute full-thickness skin-defect porcine model. There were eight Tibetan pigs in this research. Six 5 × 5 cm full-thickness skin-defect wounds were prepared on the dorsal area of each pig, which were divided into two groups. The experimental group wounds were covered by Lando® dermal scaffolds, while the other received Vaseline gauzes as blank control. At day 3, 7, 14 and 21 after injury, the general condition of wounds was observed, and wound specimens were obtained for HE staining, Masson staining and the expression of CD31, α-SMA and VEGF, which were examined by immunohistochemistry...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29279803/wound-healing-potential-of-oil-of-hypercium-perforatum-in-excision-wounds-of-male-sprague-dawley-rats
#19
Shivananada B Nayak, Kubra Isik, Julien R Marshall
Objective: To evaluate the wound-healing activity of oil of Hypercium perforatum (St. John's wort), in excision wounds of male white rats. Approach: The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Hyperforin and Hypericin are important phytochemical constituents found in H. perforatum, which have been highlighted for their antimicrobial, antiviral, and anti-inflammatory properties in recent times...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29083336/skin-graft-donor-site-a-procedure-for-a-faster-healing
#20
Roberto Cuomo, Luca Grimaldi, Cesare Brandi, Giuseppe Nisi, Carlo D'Aniello
BACKGROUND: The authors want to evaluate the efficacy of fibrillary tabotamp dressing in skin graft-donor site. A comparison was made with Vaseline gauzes. Tabotamp is an absorbable haemostatic product of Ethicon (Johnson and Johnson) obtained by sterile and oxidized regenerated cellulose (Rayon). It is used for mild to moderate bleeding. MATERIALS AND METHODS: 276 patients were subject to skin graft and divided into two group: Group A and Group B. The donor site of patients in Group A was medicated with fibrillary tabotamp, while the patients of Group B were medicated only with Vaseline gauze...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
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