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https://www.readbyqxmd.com/read/29705832/green-light-photoselective-vaporization-of-the-prostate-a-safe-and-effective-treatment-for-elderly-high-risk-benign-prostate-hyperplasia-patients-with-gland-over-80-ml
#1
Jie Sun, An Shi, Zhen Tong, Chenfei Chi
To analyze the efficacy of Green Light photoselective vaporization of the prostate (PVP) in elderly high-risk benign prostatic hyperplasia (BPH) patients with glands over 80 ml. From December 2013 to February 2016, we allocated 84 elderly (age 71-97) high-risk patients who underwent preoperative transrectal ultrasound (TRUS) examination with glands over 80 ml and divided them into two groups to receive 120 W (n = 40) and 180 W (n = 44) PVP. All the patients have been observed at least one intraoperative comorbidity: hypertension, diabetes mellitus, NYHA II, or combined...
April 28, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29645352/the-uk-rope-study-efficacy-and-safety-of-prostate-artery-embolisation-for-benign-prostatic-hyperplasia-an-observational-study-and-propensity-matched-comparison-with-transurethral-resection-of-the-prostate
#2
A F Ray, J Powell, M J Speakman, N T Longford, R DasGupta, T Bryant, S Modi, J Dyer, M Harris, G Carolan-Rees, N Hacking
OBJECTIVES: The UK Register of Prostate Embolisation (UK ROPE) study aimed to assess the efficacy and safety of Prostate Artery Embolisation (PAE) for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) patients. The main secondary aim was an indirect comparison with transurethral resection of the prostate (TURP). SUBJECTS/PATIENTS AND METHODS: As a joint initiative between BSIR, BAUS and NICE, this study recruited 305 patients across 17 UK urological / interventional radiology centres: 216 PAE, 89 TURP...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29569259/varicocele-is-the-root-cause-of-bph-destruction-of-the-valves-in-the-spermatic-veins-produces-elevated-pressure-which-diverts-undiluted-testosterone-directly-from-the-testes-to-the-prostate
#3
M Goren, Y Gat
In varicocele, there is venous flow of free testosterone (FT) directly from the testes into the prostate. Intraprostatic FT accelerates prostate cell production and prolongs cell lifespan, leading to the development of BPH. We show that in a large group of patients presenting with BPH, bilateral varicocele is found in all patients. A total of 901 patients being treated for BPH were evaluated for varicocele. Three diagnostic methods were used as follows: physical examination, colour flow Doppler ultrasound and contact liquid crystal thermography...
March 22, 2018: Andrologia
https://www.readbyqxmd.com/read/29556488/lipid-associated-antioxidants-arylesterase-and-paraoxonase-1-in-benign-prostatic-hyperplasia-treatment-na%C3%A3-ve-patients
#4
George Awuku Asare, Sabina Ekua Andam, Henry Asare-Anane, Seth Ammanquah, Yvonne Anang-Quartey, Daniel K Afriyie, Iddis Musah
Background: Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients. PON1 and ARE, a high-density lipoprotein (HDL) cholesterol-bound enzyme system of antioxidants, protect low-density lipoprotein (LDL) cholesterol and HDL from oxidation by hydrolysis...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29430969/retrospective-analysis-of-short-term-outcomes-after-monopolar-versus-laser-endoscopic-enucleation-of-the-prostate-a-single-center-experience
#5
Dmitry Enikeev, Petr Glybochko, Zhamshid Okhunov, Yuriy Alyaev, Leonid Rapoport, Dmitry Tsarichenko, Mikhail Enikeev, Nikolay Sorokin, Alim Dymov, Mark Taratkin
INTRODUCTION: Endoscopic enucleation of the prostate (EEP) has been recognized as a viable treatment modality for men with benign prostatic hyperplasia (BPH). The aim of our study was to compare the efficacy and functional outcomes of three different techniques of EEP, including monopolar enucleation (MEP), holmium laser enucleation of the prostate (HoLEP), and thulium laser enucleation of the prostate (ThuLEP). METHODS: The study consisted of a retrospective comparison of pre- and postoperative parameters in men undergoing three types of EEP: MEP, HoLEP, and ThuLEP...
March 13, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29313161/benign-prostatic-hyperplasia-surgical-scoring-bphss-an-novel-scoring-system-for-the-perioperative-outcomes-of-holmium-laser-enucleation-of-the-prostate
#6
Huan Xu, Zhikang Cai, Yanbo Chen, Meng Gu, Qi Chen, Zhong Wang
To develop a standardized scoring system, the BPH surgical scoring (BPHSS) system, to quantify the ability to predict the perioperative outcomes resulting from an enlarged prostate. There are two parts included in this study: the retrospective observational study (875 patients treated with holmium laser enucleation of the prostate, HoLEP) and the prospective observational study (111 patient underwent HoLEP). All the outcome data included the following: the basic patient preoperative characteristics, operation time (OT), pre- and post- surgery hemoglobin decrease, Na+ variation, hospital stay duration, duration of bladder irrigation, catheterization time, and hospitalization time...
April 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29135144/-the-use-of-prostadoz-in-patients-with-benign-prostatic-hyperplasia-and-coexistent-high-grade-prostatic-intraepithelial-neoplasia
#7
A G Antonov, V V Gordeev, S B Fedorchuk, D O Laptev
INTRODUCTION: In recent years there has been an increasing interest in the drug treatment of benign prostatic hyperplasia (BPH) to improve the patients quality of life without surgical treatment. In this connection, phytotherapeutic drugs and biologically active dietary supplements (BADS), consisting of a combination of microelements, vitamins and plant extracts, have been increasingly used in addition to synthetic preparations. OBJECTIVE: To investigate the clinical effectiveness of dietary supplement ProstaDoz in the treatment of BPH with coexistent high-grade prostatic intraepithelial neoplasia (PIN)...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29135141/-effectiveness-of-omnic-and-omnic-ocas-in-patients-with-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-multi-center-observing-program
#8
MULTICENTER STUDY
B U Shalekenov, Y A Kuandykov, S B Shalekenov
AIM: To investigate the effectiveness and safety of six-month treatment course of Omnic and Omnic Ocas in patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) in a routine urology practice in Kazakhstan. DESIGN: This was a multicenter prospective observational program involving the collection of data from patients with LUTS caused by BPH, who received Omnic Ocas or Omnic as the first line treatment. MATERIALS AND METHODS: The program comprised 1513 patients with a verified diagnosis of LUTS/BPH, who received Omnic Ocas or Omnic (tamsulosin) administered by urologists at hospitals in the Republic of Kazakhstan...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29135135/-ultrasound-indicators-of-the-prostate-urinary-bladder-and-uroflowmetry-parameters-in-the-diagnosis-of-infravesical-obstruction-in-men-with-benign-prostatic-hyperplasia
#9
G G Krivoborodov, N S Efremov, A D Bolotov
RELEVANCE: Benign prostatic hyperplasia (BPH) is one of the most common urologic diseases of males. In patients who failed drug therapy of lower urinary tract symptoms (LUTS) caused by BPH, the most important indication for surgery is the presence of infravesical obstruction (IVO). IVO is detected by pressure-flow studies and is characterized by high detrusor pressure with decreased urinary flow rate. The invasiveness and high cost of this investigation has stimulated a search for non-invasive techniques that could reliably characterize the presence of IVO secondary to BPH...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29129027/factors-affecting-the-efficacy-and-safety-of-phosphodiesterase-5-inhibitor-and-placebo-in-treatment-for-lower-urinary-tract-symptoms-meta-analysis-and-meta-regression
#10
Hwa Yeon Sun, Bora Lee, Jae Heon Kim
PURPOSE: We aimed to investigate the real benefit and safety of phosphodiesterase 5 inhibitor (PDE 5I) for benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) by determining the affecting factors and to overcome the previous meta-analysis studies. METHODS: We conducted a systematic review of improvements in LUTS using International Prostate Symptom Score (IPSS), voiding subscore of IPSS (voiding IPSS), storage subscore of IPSS (storage IPSS), quality of life (QoL), maximal urinary flow rate (Qmax), and post-voided residual volume (PVR), and also investigated adverse events and relevant withdrawal rate...
January 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29128994/radiologists-preferences-regarding-content-of-prostate-mri-reports-a-survey-of-the-society-of-abdominal-radiology
#11
Benjamin Spilseth, Daniel J Margolis, Sangeet Ghai, Nayana U Patel, Andrew B Rosenkrantz
PURPOSE: To evaluate radiologist preferences regarding specific content that warrants inclusion in prostate MRI reports. METHODS: Sixty-one members of the Society of Abdominal Radiology responded to a 74-item survey regarding specific content warranted in prostate MRI reports, conducted in August 2016. RESULTS: General items deemed essential report content by ≥ 50% of respondents were prostate volume (80%), extent of prostate hemorrhage (74%), TURP defects (69%), coil type (64%), BPH (61%), contrast dose (61%), contrast agent (59%), medications administered (59%), and magnet strength (54%)...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29048492/stability-indicating-uplc-and-tlc-densitometric-methods-for-determination-of-benztropine-mesylate-and-its-carcinogenic-degradation-product
#12
Michel Y Fares, Nada S Abdelwahab, Maha M Abdelrahman, Hamdy M Abdel-Rahman
Two accurate, precise and highly selective stability-indicating methods were adopted for simultaneous determination of benztropine mesylate (BNZ) in presence of its hepatotoxic and carcinogenic degradation product, benzophenone (BPH) either in pure form or in the pharmaceutical formulation without any preliminary separation steps. The first method is a thin layer chromatography (TLC)-densitometric method that depended on separation of BNZ from its degradate on TLC aluminum plates precoated with silica gel 60 F254 as the stationary phase using a developing system consisted of hexane:methylene chloride:triethylamine (5:5:0...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28991765/effects-of-serenoa-repens-alcohol-extract-on-benign-prostate-hyperplasia
#13
Skender Saidi, Sotir Stavridis, Oliver Stankov, Sasho Dohcev, Sasho Panov
An increasing tendency has recently emerged for the use of phytotherapeutic agents as alternative to commercial pharmacological agents for the treatment of benign prostate hyperplasia (BPH). The purpose of this study is to evaluate the effects of Serenoa repens alcohol extract treatment on BPH patients' symptoms and major parameters during one-year follow-up. The study was performed on 70 men aged 40 - 79 years (mean 60.58) with symptomatic BPH that were divided into a group of 40 patients treated with Serenoa repens extract (SRT) and a control group of 30 patients that received no treatment and were observed only...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28986510/combined-18-f-fluciclovine-pet-mri-shows-potential-for-detection-and-characterization-of-high-risk-prostate-cancer
#14
Mattijs Elschot, Kirsten M Selnæs, Elise Sandsmark, Brage Krüger-Stokke, Øystein Størkersen, Guro F Giskeødegård, May-Britt Tessem, Siver A Moestue, Helena Bertilsson, Tone F Bathen
The objective of this study is to investigate if quantitative imaging features derived from combined (18)F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for detection and characterization of primary prostate cancer. Methods: Twenty-eight (28) patients diagnosed with high-risk prostate cancer underwent simultaneous (18)F-Fluciclovine PET/MRI before radical prostatectomy. Volumes-of-interest (VOIs) of prostate tumors, benign prostatic hyperplasia (BPH) nodules, prostatitis, and healthy tissue were delineated on T2-weighted images using histology as a reference...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28948696/benign-prostatic-hyperplasia-long-term-follow-up-of-prostate-volume-reduction-after-sclerotherapy-of-the-internal-spermatic-veins
#15
Y Gat, M Goren
The purpose was to examine the results of bilateral percutaneous sclerotherapy of the internal spermatic veins on prostate volume and prostatic symptoms. We previously showed that destruction of one-way valves in the internal spermatic veins (varicocele) elevates hydrostatic pressure in the vertical testicular venous drainage system in the erect human. This diverts free testosterone (FT) flow at high concentrations directly from the testes into the prostate. High intraprostatic FT prolongs prostate cell life and increases cell proliferation rate-synergistic effects resulting in increased cell population (BPH)...
March 2018: Andrologia
https://www.readbyqxmd.com/read/28902866/5-year-long-term-efficacy-of-120-w-greenlight-photoselective-vaporization-of-the-prostate-for-benign-prostate-hyperplasia
#16
Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
PURPOSE: To investigate 5-year long-term postoperative efficacy in benign prostate hyperplasia (BPH) following 120-W GreenLight high-performance system photoselective vaporization of the prostate (HPS-PVP). METHODS: This was a retrospective study of surgical outcomes in 159 men who underwent HPS-PVP and were followed over 60 months postoperatively. Definitions of treatment success were established based on the following three variables: international prostate symptom scores (IPSS), maximum flow rates (Qmax), and quality of life scores QoL)...
2017: PloS One
https://www.readbyqxmd.com/read/28889714/-clinical-study-of-holep-for-the-patients-with-benign-prostatic-hyperplasia-who-are-on-oral-antithrombotics
#17
Takashi Matuoka, Issei Suzuki, Ryosuke Suzuki, Arinobu Fukunaga, Yoichiro Dohi, Yoshio Sugino, Koji Inoue, Mutsushi Kawakita
Recently, holmium laserenucleation of the prostate (HoLEP) was associated with less bleeding compared with transurethral resection of prostate. Since 2012, we have performed HoLEP for benign prostatic hyperplasia (BPH) under continuous oral antithrombotics (OA). Between October 2004 and March 2015, 54 patients with BPH underwent HoLEP while on OA at our hospital. Eight patients underwent HoLEP without OA cessation and 46 patients with temporary OA cessation. No significant between-group difference was observed in age, prostate volume, transitional zone prostate volume, operation time, resection weight, resection weight per minute, urethral catheter duration, Hb decrease on day 1 post- HoLEP, hospital stay after HoLEP, bleeding intraoperative rate, bleeding rate after HoLEP and transfusion rate...
August 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28860509/age-related-differences-in-responsiveness-to-sildenafil-and-tamsulosin-are-due-to-myogenic-smooth-muscle-tone-in-the-human-prostate
#18
Sophie N Lee, Basu Chakrabarty, Brad Wittmer, Melissa Papargiris, Andrew Ryan, Mark Frydenberg, Nathan Lawrentschuk, Ralf Middendorff, Gail P Risbridger, Stuart J Ellem, Betty Exintaris
Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) are highly prevalent in older men, having a profound impact on patient quality of life. Current therapeutics for BPH/LUTS target neurogenic smooth muscle tone, but response is unpredictable and many patients fail to respond. Spontaneous myogenic tone is another component of smooth muscle contractility that is uncharacterized in human prostate. To better understand and improve the predictability of patient response, we defined myogenic contractility using human prostate specimens and examined the effect of existing therapeutics...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780626/prospective-controlled-assessment-of-men-s-sexual-function-changes-following-holmium-laser-enucleation-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia
#19
Ahmed M Elshal, Ahmed El-Assmy, Ramy Mekkawy, Diaa-Eldin Taha, Ahmed R El-Nahas, Mahmoud Laymon, Hamdy El-Kappany, El-Housseiny Ibrahiem
OBJECTIVES: To assess how much Holmium laser enucleation of the prostate (HoLEP) is detrimental on men sexuality. METHODS: Between January and December 2013, all patients presented for BPH surgery were assessed using IIEF-15 (international index of erectile function-15) and Ej-MSHQ (ejaculatory domain-male sexual health questionnaire). Changes in men's sexuality following HoLEP in relation to control procedure were prospectively assessed. Intervention group included legible consecutive patients treated by HoLEP...
October 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28632494/long-term-dutasteride-therapy-in-men-with-benign-prostatic-hyperplasia-alters-glucose-and-lipid-profiles-and-increases-severity-of-erectile-dysfunction
#20
Abdulmaged Traish, Karim Sultan Haider, Gheorghe Doros, Ahmad Haider
Background Dutasteride has been successfully used in treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). However, dutasteride inhibits 5α-reductase type 1 and type 2 enzymes and may compromises glucocorticoids and androgen metabolism and alters metabolic function resulting in undesirable metabolic and sexual adverse side effects. Aim The aim of this study was to investigate the long-term adverse effects of dutasteride therapy in men with BPH on: i) blood glucose, ii) glycated hemoglobin (HbA1c), iii) low density lipoprotein-cholesterol (LDL-C); high density lipoprotein-cholesterol (HDL-C) and total cholesterol (TC), iv) testosterone (T), v) liver alanine and aspartate aminotransferases (ALT and AST) and vi) erectile dysfunction (ED)...
June 21, 2017: Hormone Molecular Biology and Clinical Investigation
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