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Thyroid imaging

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https://www.readbyqxmd.com/read/29162036/sorafenib-treatment-for-papillary-thyroid-carcinoma-with-diffuse-lung-metastases-in-a-child-with-autism-spectrum-disorder-a-case-report
#1
Yousuke Higuchi, Takayuki Motoki, Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Takanori Oyama, Takuo Noda, Yasuko Tsurumaru, Ayumi Okada, Hirokazu Tsukahara, Akira Shimada
BACKGROUND: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging. CASE PRESENTATION: An 11-year-old boy with autism spectrum disorder and moderate intellectual impairment presented with dyspnea on exertion with thyroid carcinoma and diffuses lung metastases...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29160180/incidental-findings-on-fdg-pet-ct-in-head-and-neck-cancer
#2
Christopher J Britt, Austin M Maas, Tabassum A Kennedy, Gregory K Hartig
Objective 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG PET/CT) imaging is common in head and neck cancer and often identifies incidental findings that necessitate additional patient evaluations. Our goal was to assess the frequency and nature of these incidental imaging findings on FDG-PET/CT. Study Design Retrospective cohort study. Setting Tertiary medical center. Subjects and Methods All patients with head and neck cancer who had undergone FDG-PET/CT imaging between January 2014 and June 2015 at our institution were evaluated for incidental findings...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29158366/therapeutic-anticoagulation-in-patients-with-primary-brain-tumors-or-secondary-brain-metastasis
#3
REVIEW
Richard J Lin, David L Green, Gunjan L Shah
Patients with primary or metastatic brain tumors are at increased risk of developing venous thromboses. However, the potential benefit of therapeutic anticoagulation in these patients must be weighed against the deadly complication of intracranial hemorrhage. In this review, we summarize available evidence and recent studies of intracranial bleeding risks in primary and metastatic tumors and the impact of therapeutic anticoagulation. We find that for the majority of primary and treated metastatic brain tumors, the risk of spontaneous bleeding is acceptable and not further increased by careful therapeutic anticoagulation with low molecular weight heparin or direct oral anticoagulants, although thrombocytopenia (platelet count less than 50,000/μL) and other coagulopathies are relative contraindications...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29152294/awake-tracheotomy-in-a-patient-with-stridor-and-dyspnoea-caused-by-a-sizeable-malignant-thyroid-tumor-a-case-report-and-short-review-of-the-literature
#4
Andreas Hohn, Tālis Kauliņš, Jochen Hinkelbein, Krista Kauliņa, Andreas Kopp, Sebastian G Russo, Sigurd Kohlen, Stefan Schröder
Individual airway management is mandatory in patients with large goiters undergoing thyroid surgery. Preoperative endoscopic airway evaluation and imaging studies can support clinical decision making. Awake tracheotomy can be an effective and reasonable airway management strategy in such patients.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29152292/concomitant-occurrence-of-primary-hyperparathyroidism-phpt-due-to-mediastinal-parathyroid-adenoma-and-sublingual-thyroid-gland-the-role-of-parathyroid-technetium-99m-mibi-scintigraphy
#5
Sara Choukry, Jaafar Benouhoud, Ghofrane Cherkaoui Salhi, Sara Taleb, Amal Guensi, Karim Choukry
The concomitant appearance of a sublingual thyroid and primary hyperparathyroidism due to parathyroid mediastinal adenoma is not common. This co-occurrence can lead to a misdiagnosis by morphological imaging methods alone. This case emphasizes the role of 99mTc-MIBI scintigraphy in the detection of parathyroid ectopic adenoma in a patient with an ectopic thyroid gland. This more accurate location of parathyroid scintigraphy is of great benefit to the surgeon for surgical excision.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29150742/associations-between-nucleus-size-and-immunohistochemical-galectin-3-cytokeratine-19-and-hbme-1-markers-in-thyroid-papillary-carcinoma-a-morphometric-analyze
#6
Hatice Toy, Ozlem Etli, Zeliha Esin Celik, Arsenal Sezgin Alikanoglu
This study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining...
November 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#7
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29142851/the-use-of-icg-enhanced-fluorescence-for-the-evaluation-of-parathyroid-gland-preservation
#8
REVIEW
Pornpeera Jitpratoom, Angkoon Anuwong
Indocyanine green (ICG) enhanced fluorescence imaging is recent innovation as the "real-time intraoperative imaging" technique. Many clinical studies have been reported in the literature which use different devices and techniques that employ various doses and usages of ICG as a non-specific contrast agent. Several groups have performed studies in endocrine surgery, especially with regards to parathyroid-related outcomes after thyroid and parathyroid surgery. However, there is no consensus on the technical details that should be applied...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142843/intraoperative-real-time-localization-of-parathyroid-gland-with-near-infrared-fluorescence-imaging
#9
REVIEW
Sung Won Kim, Hyoung Shin Lee, Kang Dae Lee
Surgeons have cited difficulties in identifying the parathyroid glands (PG) during thyroidectomy. To overcome the limitation of naked eye, many studies on near-infrared fluorescence imaging of PGs have been introduced and suggested that fluorescence imaging is useful for both localizing PGs and evaluating their function. This imaging technique has been reported in two ways: (I) imaging using a fluorescent material called indocyanine green (ICG); and (II) autofluorescence using intrinsic fluorophores. These innovative and novel techniques are expected to have a significant impact on performing thyroid or parathyroid surgery...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29140118/-11-c-choline-pet-ct-for-detection-and-localization-of-parathyroid-adenomas
#10
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of (11)C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 (11)C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29130586/prognostic-implication-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-recurrent-papillary-thyroid-cancer
#11
Ji-Hun Kang, Da-Woon Jung, Kyoung-June Pak, In-Ju Kim, Hak-Jin Kim, Jae-Keun Cho, Sung-Chan Shin, Soo-Geun Wang, Byung-Joo Lee
BACKGROUND: Fluorine-18 fluorodeoxyglucose positron emission tomography/CT ((18) F-FDG PET/CT) has been widely accepted as an effective method for detecting recurrent papillary thyroid cancer (PTC) in patients with increased serum thyroglobulin (Tg) or Tg antibody (TgAb) levels and negative whole-body scintigraphy (WBS) results. The role of WBS as a diagnostic tool in detecting recurrence has relatively decreased recently. However, only a few studies have examined the usefulness of (18) F-FDG PET/CT for evaluating patients with recurrent PTC, regardless of the WBS results...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29128184/importance-of-surgeon-performed-ultrasound-in-the-preoperative-nodal-assessment-of-patients-with-potential-thyroid-malignancy
#12
Rosebel Monteiro, Amy Han, Muhammad Etiwy, Andrew Swearingen, Vikram Krishnamurthy, Judy Jin, Joyce J Shin, Eren Berber, Allan E Siperstein
INTRODUCTION: A comprehensive cervical ultrasound evaluation is essential in the operative planning of patients with thyroid disease. Reliance on radiographic reports alone may result in incomplete operative management as pathologic lymph nodes are often not palpable and evaluation of the lateral neck is not routine. This study examined the role of surgeon-performed ultrasound in the evaluation of patients who underwent lateral neck dissection for thyroid cancer. METHODS: We conducted a retrospective review of a prospectively maintained database of patients who underwent therapeutic lymph node dissection for thyroid cancer between 2001 and 2016 at our tertiary referral center...
November 8, 2017: Surgery
https://www.readbyqxmd.com/read/29127244/imaging-of-the-thyroid-and-parathyroid-using-a-cardiac-cadmium-zinc-telluride-camera-phantom-studies
#13
Yosuke Miyazaki, Yasuhiro Kato, Akira Imoto, Kazuki Fukuchi
Purpose: Cadmium zinc telluride (CZT) detectors have recently been introduced to the field of clinical nuclear cardiology. However, the feasibility of using them for organs other than the heart remains unclear. The aim of this study was to evaluate the potential of a cardiac CZT camera to acquire thyroid and parathyroid images. We used custom-made phantoms and the currently available standard protocols for CZT, instead of a sodium-iodine scintillation (NaI) camera. Materials and Methods: Thyroid phantoms with or without parathyroid adenomas were made from agar using radiopharmaceuticals ((99m)Tc or (123)I) and imaged using CZT and NaI cameras...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29127242/gamma-camera-based-method-for-131-i-capsule-counting-an-alternate-method-to-uptake-probe-method
#14
Biju K Menon, Awasare S Uday, Baghel N Singh
The main objective of this study was to check the validity of using gamma camera as an alternate method to thyroid uptake probe, for counting 25uCi (0.925 MBq) and 50uCi (1.85 MBq) (131)I capsules before administration to thyroid patients. Methods: - 10 sets each of 25uCi (0.925 MBq) and 50uCi (1.85 MBq) (131)I capsules received from Board Of Radiation and Isotope Technology, Department Of Atomic Energy, India (BRIT, DAE) have been counted individually using thyroid uptake probe for 10 seconds following institutional protocol and also by keeping individual capsule of a set with 8cm gap between each of them ...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29126111/second-radioiodine-treatment-limited-benefit-for-differentiated-thyroid-cancer-with-loforegional-persistent-disease
#15
Dania Hirsch, Alexander Gorshtein, Eyal Robenshtok, Hiba Masri-Iraqi, Amit Akirov, Hadar Duskin Bitan, Ilan Shimon, Carlos Benbassat
Purpose: Radioactive iodine (RAI) treatment is often indicated after total thyroidectomy in differentiated thyroid cancer (DTC). However, its role in biochemical or loco-regional persistent DTC is unclear. We aimed to investigate the impact of a second RAI treatment in patients with incomplete response to initial treatment and no evidence of distant metastases. Methods: Patients who underwent at least two RAI treatments over a 20-year period at a tertiary hospital were identified...
November 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122718/near-infrared-autofluorescence-image-guided-parathyroid-gland-mapping-in-thyroidectomy
#16
Sung Won Kim, Hyoung Shin Lee, Yeh-Chan Ahn, Chan Woo Park, Seok Won Jeon, Chang Hoi Kim, Jae Beom Ko, Chulho Oak, Yikeun Kim, Kang Dae Lee
BACKGROUND: Studies to date have shown that near-infrared autofluorescence imaging (NIR) can detect the parathyroid gland during thyroidectomy. However, there are no reports that NIR imaging can identify the parathyroid gland when covered with fibrofatty tissue before identification by a surgeon's naked eye. In this study, we investigated the feasibility of parathyroid gland mapping to facilitate early identification of the parathyroid gland during thyroidectomy. STUDY DESIGN: Seventy parathyroid glands from 38 patients who underwent thyroidectomy for papillary thyroid cancer were included in this prospective study...
November 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29120064/size-and-ultrasound-features-affecting-results-of-ultrasound-guided-fine-needle-aspiration-of-thyroid-nodules
#17
YiJie Dong, MinJing Mao, WeiWei Zhan, JianQiao Zhou, Wei Zhou, JieJie Yao, YunYun Hu, Yan Wang, TingJun Ye
OBJECTIVES: Our goal was to assess the diagnostic efficacy of ultrasound (US)-guided fine-needle aspiration (FNA) of thyroid nodules according to size and US features. METHODS: A retrospective correlation was made with 1745 whole thyroidectomy and hemithyroidectomy specimens with preoperative US-guided FNA results. All cases were divided into 5 groups according to nodule size (≤5, 5.1-10, 10.1-15, 15.1-20, and >20 mm). For target nodules, static images and cine clips of conventional US and color Doppler were obtained...
November 9, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29118474/cytological-evaluation-of-thyroid-lesions-by-nuclear-morphology-and-nuclear-morphometry
#18
R Yashaswini, T N Suresh, A Sagayaraj
Introduction: Fine needle aspiration (FNA) of the thyroid gland is an effective diagnostic method. The Bethesda system for reporting thyroid cytopathology classifies them into six categories and gives implied risk for malignancy and management protocol in each category. Though the system gives specific criteria, diagnostic dilemma still exists. Using nuclear morphometry, we can quantify the number of parameters, such as those related to nuclear size and shape. The evaluation of nuclear morphometry is not well established in thyroid cytology...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29116052/quantitative-performance-evaluation-of-sup-124-sup-i-pet-mri-lesion-dosimetry-in-differentiated-thyroid-cancer
#19
Roel Wierts, Walter Jentzen, Harald H Quick, Hendrik J Wisselink, Ivo N A Pooters, Joachim E Wildberger, Ken Herrmann, Gerrit J Kemerink, Walter H Backes, Felix M Mottaghy
The aim was to investigate the quantitative performance of 124I PET/MRI for pre-therapy lesion dosimetry in differentiated thyroid cancer. Phantom measurements were performed on a PET/MRI system (Biograph mMR, Siemens Healthcare) using 124I and 18F. The PET calibration factor and the influence of radiofrequency coil attenuation were determined using a cylindrical phantom homogeneously filled with radioactivity. The calibration factor was 1.00 ± 0.02 for 18F and 0.88 ± 0.02 for 124I. Near the radiofrequency surface coil an underestimation of less than 5% in radioactivity concentration was observed...
November 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29115061/carcinoma-showing-thymus-like-elements-report-of-a-case-with-egfr-t790m-mutation
#20
Madhu Rajeshwari, Varsha Singh, Aruna Nambirajan, Asit Ranjan Mridha, Deepali Jain
Carcinoma showing thymus-like differentiation of the thyroid (CASTLE) is a rare tumor involving the thyroid and perithyroidal soft tissues. It shares morphological, immunohistochemical and molecular similarities with thymic carcinomas. Due to its relatively better prognosis, it needs differentiation from other primary and metastatic tumors of this region. A 40-year-old lady presented with a gradually progressive anterior neck swelling for one year. Imaging showed bulky right and left lobes of thyroid along with a solid soft tissue mass in the pretracheal region...
November 8, 2017: Diagnostic Cytopathology
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