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Thyroid imaging

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https://www.readbyqxmd.com/read/28927107/comparison-of-the-effectiveness-of-ultrasound-elastography-with-that-of-conventional-ultrasound-for-differential-diagnosis-of-thyroid-lesions-with-suspicious-ultrasound-features
#1
Jinru Yang, Yan Song, Wei Wei, Litao Ruan, Hong Ai
Ultrasound elastography (USE) has been used for quantitative imaging since the early 1990s. The aim of the present study was to compare the effectiveness of USE with that of conventional ultrasound in the differential diagnosis of benign vs. malignant thyroid nodules. USE was performed on 150 thyroid nodules in 123 patients. USE demonstrated a lower grade of elasticity (grade I/II) in 86% of benign nodules and a decreased strain ratio (2.30±1.01) compared with malignant nodules. USE of malignant nodules exhibited a higher grade of elasticity (grade III/IV) in 90% of nodules and an increased strain ratio (6...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925594/pharyngoesophageal-diverticula-simulating-thyroid-nodules-an-unusual-occurrence-with-unique-features
#2
Karen K Nauschuetz, Lorna L Ogden, Cherry E Starling, Mohammad J Saleh, Allan C Golding, S Thomas Traweek
Pharyngoesophageal diverticula (PED) of the Zenker's and Killian-Jamieson types arise in close proximity to the thyroid gland, and may rarely be confused with a thyroid nodule on ultrasonography. In this brief report, we detail the cytologic, clinical, and radiologic findings of three PED that were thought to be thyroid nodules, and were subjected to fine-needle aspiration (FNA). The patients were females with an age range of 51-64 years. All three patients had multiple thyroid nodules, and two patients reported symptoms attributable to the diverticulum...
September 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28921623/one-step-synthesis-of-18-f-cabozantinib-for-use-in-positron-emission-tomography-imaging-of-c-met
#3
Vegard Torp Lien, Jo Klaveness, Dag Erlend Olberg
Cabozantinib is an FDA approved kinase inhibitor for the treatment of medullary thyroid cancer and advanced renal cell carcinoma, which exerts its therapeutic effect by inhibiting, among others, the tyrosine kinase c-Met. Non-invasive imaging techniques are becoming increasingly important clinically to ensure drug efficacy, staging, monitoring and patient stratification. PET isotope labelled tyrosine kinase inhibitors have, for the same reason, potential as PET tracers for imaging of various cancers. Based on cabozantinib, we synthesized the novel boronic acid pinacol ester 4 as a labelling precursor, where the boronic ester moiety replaces the fluorine native to this kinase inhibitor...
September 18, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#4
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28919625/van-wyk-and-grumbach-syndrome-an-unusual-presentation-of-hypothyroism
#5
P K Chanda, M Kamrul-Hasan, M Abu-Bakar, M Rahman, M A Kader, M A Hossain, N I Siddiqui
An 18 years-old-girl presented one and half years back with the complaints of short stature, retarded growth, and menorrhagia with sudden severe lower abdominal pain; was diagnosed as bilateral ovarian cysts and underwent bilateral ovarian cystectomy. Later on she was incidentally diagnosed as a case of hypothyroidism when she had been experiencing slowly enlarging left lower abdominal mass with dull ache for the 5 month and then was transferred to the department of Endocrinology for further evaluation. Detailed work up revealed her short stature with obesity, delayed bone age and other features of hypothyroidism which was confirmed by thyroid function testing...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28916508/development-of-a-whole-slide-imaging-system-on-smartphones-and-evaluation-with-frozen-section-samples
#6
Hong Yu, Feng Gao, Liren Jiang, Shuoxin Ma
BACKGROUND: The aim was to develop scalable Whole Slide Imaging (sWSI), a WSI system based on mainstream smartphones coupled with regular optical microscopes. This ultra-low-cost solution should offer diagnostic-ready imaging quality on par with standalone scanners, supporting both oil and dry objective lenses of different magnifications, and reasonably high throughput. These performance metrics should be evaluated by expert pathologists and match those of high-end scanners. OBJECTIVE: The aim was to develop scalable Whole Slide Imaging (sWSI), a whole slide imaging system based on smartphones coupled with optical microscopes...
September 15, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28912438/malignancy-risk-stratification-of-thyroid-nodules-comparisons-of-four-ultrasound-thyroid-imaging-reporting-and-data-systems-in-surgically-resected-nodules
#7
Ying Wang, Kai-Rong Lei, Ya-Ping He, Xiao-Long Li, Wei-Wei Ren, Chong-Ke Zhao, Xiao-Wan Bo, Dan Wang, Cheng-Yu Sun, Hui-Xiong Xu
To compare the efficiency of four different ultrasound (US) Thyroid Imaging Reporting and Data Systems (TI-RADS) in malignancy risk stratification in surgically resected thyroid nodules (TNs). The study included 547 benign TNs and 464 malignant TNs. US images of the TNs were retrospectively reviewed and categorized according to the TI-RADSs published by Horvath E et al. (TI-RADS H), Park et al. (TI-RADS P), Kwak et al. (TI-RADS K) and Russ et al. (TI-RADS R). The diagnostic performances for the four TI-RADSs were then compared...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911729/chemotherapy-and-tyrosine-kinase-inhibitors-for-medullary-thyroid-cancer
#8
REVIEW
Julien Hadoux, Martin Schlumberger
Medullary thyroid cancer (MTC) represents 3% of all clinical thyroid cancers and arises from thyroid C cells that produce calcitonin. Locally advanced or metastatic MTC requires a careful work-up including measurement of serum calcitonin and carcinoembryonic antigen, determination of their doubling time and comprehensive imaging to determine the extent of the disease, its aggressiveness, and the need for treatment. Cytotoxic chemotherapy can control tumor burden in some patients with response rates of around 20% in old series...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#9
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28910894/-diagnostic-values-of-braf-v600e-mutation-analysis-and-bethesda-system-for-reporting-thyroid-cytopathology-in-thyroid-nodules-with-tirads-4-and-5
#10
Y Han, B W Zhao, S Y Li, J G Lyu, J D Shou, H S Xu, H Y Lou, L L Xu, L Gao, S X Xu, J Zhu
Objective: To evaluate the diagnostic efficacies of BRAF(V600E) testing and Bethesda system for reporting thyroid cytopathology (BSRTC) in thyroid nodules with thyroid imaging reporting and data system (TIRADS) category 4 and 5. Methods: A total of 187 thyroid nodules in 187 patients underwent the examinations of ultrasound-guided fine needle aspiration cytology (FNAC) and BRAF(V600E) mutation were analyzed retrospectively. Receive operating characteristic (ROC) curve was used to investigate the diagnostic values of both methods and the clinical application of BRAF(V600E) combined with BSRTC was evaluated...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28905143/the-value-of-quantitative-shear-wave-elastography-in-differentiating-the-cervical-lymph-nodes-in-patients-with-thyroid-nodules
#11
Jun You, Juan Chen, Feixiang Xiang, Yue Song, Simai Khamis, Chengfa Lu, Qing Lv, Yanrong Zhang, Mingxing Xie
PURPOSE: This study aimed at evaluating the diagnostic performance of quantitative shear wave elastography (SWE) in differentiating metastatic cervical lymph nodes from benign nodes in patients with thyroid nodules. METHODS: One hundred and forty-one cervical lymph nodes from 39 patients with thyroid nodules that were diagnosed as papillary thyroid cancer had been imaged with SWE. The shear elasticity modulus, which indicates the stiffness of the lymph nodes, was measured in terms of maximum shear elasticity modulus (maxSM), minimum shear elasticity modulus (minSM), mean shear elasticity modulus (meanSM), and standard deviation (SD) of the shear elasticity modulus...
September 13, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28902733/131i-whole-body-scan-incidental-uptake-due-to-spermatocele
#12
Domenico Albano, Federica Motta, Carla Baronchelli, Silvia Lucchini, Francesco Bertagna
A 46-year-old man with papillary thyroid cancer post total thyroidectomy was referred for post radioiodine (I) whole-body scan. Whole-body images revealed intense I uptake in the bed thyroid and a focal abnormal uptake in the testicular area. Subsequent SPECT/CT demonstrated that the focal uptake corresponded to the left epididymis, and the pathology report revealed a spermatocele with no immunohistochemical features for thyroid tissue. Many cases of unexpected radioiodine uptake have been reported, and spermatocele could be counted for another possibility of incidental I uptake despite an unclear mechanism...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28902384/-multiple-endocrine-neoplasia
#13
Ludwig Schaaf, Friedhelm Raue
Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. The clinical expression of the different tumors can vary within and between families, with a good genotype-phenotype correlation in MEN2...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28902009/risk-vessels-of-retropharyngeal-hematoma-during-stellate-ganglion-block
#14
Kazunori Hirota, Kazuhiko Hirata, Shiho Shibata, Kenji Shigematsu, Kazuo Higa, Ken Yamaura
BACKGROUND AND OBJECTIVE: Bleeding into the retropharyngeal space is a potential complication in stellate ganglion block (SGB). Retropharyngeal hematoma formation is considered to be due to damage of small arteries in the region, although only scanty details of the region are available. The aim of this study was to map the risk blood vessels in the retropharyngeal space to avoid accidental damage during SGB. METHODS: Contrast-enhanced 3-dimensional computed tomography images performed on 80 patients were reanalyzed retrospectively to construct detailed map of cervical blood vessels that are prone to damage and bleeding during SGB...
September 9, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#15
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28893408/inflammatory-myopathy-associated-with-antimitochondrial-antibodies-a-distinct-phenotype-with-cardiac-involvement
#16
Jemima Albayda, Aamna Khan, Livia Casciola-Rosen, Andrea M Corse, Julie J Paik, Lisa Christopher-Stine
OBJECTIVE: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with antimitochondrial antibodies. We sought to review all cases of antimitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset. METHODS: We identified 7 patients with confirmed antimitochondrial antibodies who presented as an inflammatory myopathy...
June 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28891406/clinical-practice-guideline-evaluation-of-the-neck-mass-in-adults
#17
Melissa A Pynnonen, M Boyd Gillespie, Benjamin Roman, Richard M Rosenfeld, David E Tunkel, Laura Bontempo, Itzhak Brook, Davoren Ann Chick, Maria Colandrea, Sandra A Finestone, Jason C Fowler, Christopher C Griffith, Zeb Henson, Corinna Levine, Vikas Mehta, Andrew Salama, Joseph Scharpf, Deborah R Shatzkes, Wendy B Stern, Jay S Youngerman, Maureen D Corrigan
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms. Malignant neoplasms far exceed any other etiology of adult neck mass. Importantly, an asymptomatic neck mass may be the initial or only clinically apparent manifestation of head and neck cancer, such as squamous cell carcinoma (HNSCC), lymphoma, thyroid, or salivary gland cancer. Evidence suggests that a neck mass in the adult patient should be considered malignant until proven otherwise...
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28887401/proposal-of-a-structured-reporting-system-for-prostate-specific-membrane-antigen-psma-targeted-pet-imaging-psma-rads-version-1-0
#18
Steven Rowe, Kenneth Pienta, Martin G Pomper, Michael Gorin
As medical imaging has grown progressively more complicated and sub-specialized in recent decades, a number of standardized reporting systems have been proposed for a variety of imaging modalities and conditions. These include reporting and data systems for imaging of the breast (BI-RADS) (1), prostate (PI-RADS) (2), lung (LUNG-RADS) (3), liver (LI-RADS) (4), and thyroid (TI-RADS) (5). While these systems differ extensively in their details, each provides a standardized framework for conveying findings and recommendations to clinicians...
September 8, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28886900/clinical-and-imaging-differences-between-neonates-and-children-with-pyriform-sinus-fistula-which-is-preferred-for-diagnosis-computed-tomography-or-barium-esophagography
#19
Jing Pan, Yan Zou, Le Li, Tian-You Yang, Ji-Liang Yang, Chao Hu
PURPOSE: Pyriform sinus fistula (PSF) is very rare. It is difficult to make an accurate diagnosis preoperatively. The aim of this study is to summarize the characteristics of clinical and radiologic presentations in neonates and children with PSF and to assess which examination is more helpful for diagnosis. METHODS: A retrospective review was performed in 29 patients with PSF at a single center from January 2013 to September 2016. The clinical presentation, computed tomography (CT) scan/magnetic resonance imaging (MRI), and barium esophagogram were evaluated between neonates and children...
August 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28885368/successful-management-of-octreotide-insensitive-thyrotropin-secreting-pituitary-adenoma-with-bromocriptine-and-surgery-a-case-report-and-literature-review
#20
REVIEW
Chengxian Yang, Huanwen Wu, Jing Wang, Mingming Hu, Xiaoping Xing, Xinjie Bao, Renzhi Wang
RATIONALE: Case reports concerning the value of dopamine agonists in the treatment of patients with thyrotropin-secreting pituitary adenoma (TSHoma) are limited. Herein, we present a rare case of octreotide-insensitive TSHoma responding to bromocriptine therapy. PATIENT CONCERNS: A 45-year-old Chinese man was admitted to Peking Union Medical College Hospital with marked clinical manifestations of hyperthyroidism. DIAGNOSES: Thyroid function tests demonstrated elevated concentrations of free thyroid hormones in the presence of normal thyrotropin...
September 2017: Medicine (Baltimore)
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