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Late Puberty

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https://www.readbyqxmd.com/read/27866050/boucher-neuh%C3%A3-user-syndrome-a-rare-cause-of-inherited-hypogonadotropic-hypogonadism-a-case-of-two-adult-siblings-with-two-novel-mutations-in-pnpla6
#1
Jakob H Langdahl, Anja L Frederiksen, Nina Nguyen, Klaus Brusgaard, Claus B Juhl
Boucher Neuhäuser Syndrome (BNS) is a rare clinical syndrome with autosomal recessive inheritance defined by early-onset ataxia, hypogonadism and chorioretinal dystrophy. We present two siblings diagnosed with BNS in late adult life identified with compound heterozygous state of two novel PNPLA6 mutations. Five healthy siblings were non- or heterozygous carriers of the mutations. The cases, which presented with ataxia in childhood and hypogonadotropic hypogonadism (HH), were diagnosed at age 17 and 25, respectively, when examined for delayed puberty...
November 16, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27862168/late-onset-bulky-naevocytoma-of-the-perineum-masquerading-as-a-malignant-melanoma
#2
J W Huh, J Yoo, M S Kim, K H Choi, M S Jue, H J Park
Bulky naevocytoma of the perineum is a very rare variant of giant congenital melanocytic naevus (GCMN). It presents as a bulky naevocytic tumour in the perineal region with characteristic histological findings, such as extensive areas with a neural appearance called 'lames foliacees', formation of a pseudofollicular structure and extension of naevus cells between collagen bundles in a row called 'Indian-file' pattern. We report a case of late-onset bulky naevocytoma of the perineum in a 13-year-old girl. The patient presented with two bulky, pedunculated, heavily pigmented masses in the vulvar area that developed in a pre-existing GCMN lesion, which began around puberty and caused severe gait disturbance...
November 15, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27777908/body-image-and-depression-in-girls-with-idiopathic-precocious-puberty-treated-with-gonadotropin-releasing-hormone-analogue
#3
Min-Seon Choi, Eun-Young Kim
PURPOSE: Precocious puberty (PP) is associated with psychological and behavioral problems. This study aimed to evaluate the perception of body image and depression in girls with PP receiving gonadotropin-releasing hormone (GnRH) analogue therapy. METHODS: From March to August 2013, 82 girls with PP receiving GnRH analogue therapy were enrolled. Height, weight, body mass index, and stages of pubertal development were assessed. Participants completed a series of questionnaires on their body image perception and pubertal self-assessment...
September 2016: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27769633/urine-bisphenol-a-and-pubertal-development-in-boys
#4
Ziliang Wang, Dekun Li, Maohua Miao, Hong Liang, Jianping Chen, Zhijun Zhou, Chunhua Wu, Wei Yuan
BACKGROUND: Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. Animal studies suggest that BPA may perturb pubertal development in males, although studies in humans are limited. OBJECTIVE: This study investigated the association between BPA exposure and pubertal onset and progression among school-aged boys in Shanghai, China. METHODS: A total of 671 boys aged 9-18 years from three schools (one elementary, one middle, and one high school) in Shanghai were enrolled in a cross-sectional study...
January 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27743688/puberty-ovarian-cycle-pregnancy-and-postpartum-ovulation-in-captive-sichuan-golden-monkeys-rhinopithecus-roxellana-based-on-changes-in-urinary-and-fecal-gonadal-steroid-metabolites
#5
Muren, Satoshi Kusuda, Osamu Doi, Hitomi Naito, Hisashi Hashikawa
The purpose of this study was to evaluate the reproductive status and clarify the reproductive physiology of captive Sichuan golden monkeys. The concentrations of urinary estradiol-3-glucuronide (E2G) and pregnanediol-glucuronide (PdG) or fecal estradiol-17β (E2) and PdG in two females, and fecal testosterone concentrations in a male, were measured continuously using enzyme immunoassays. On the basis of these hormone profiles, the follicular phase, luteal phase, and ovarian cycle were calculated to be 14.7 ± 4...
September 8, 2016: Theriogenology
https://www.readbyqxmd.com/read/27662834/age-at-menarche-in-korean-adolescents-trends-and-influencing-factors
#6
Mee-Hwa Lee, Shin Hye Kim, Minkyung Oh, Kuk-Wha Lee, Mi-Jung Park
BACKGROUND: An increased incidence of central precocious puberty has been recently reported in South Korea, which suggests an ongoing downward trend in pubertal development in the Korean population. We aimed to verify the trend in age at menarche in young Korean women during the last decade and associated factors. METHODS: We analyzed a population-based sample of 3409 Korean girls, aged 10-18 years, using data from the Korean National Health and Nutrition Examination Surveys (KNHANES) II (2001), III (2005), IV (2007-2009), and V (2010 and 2011)...
2016: Reproductive Health
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#7
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27611179/testicular-function-during-puberty-and-young-adulthood-in-patients-with-klinefelter-s-syndrome-with-and-without-spermatozoa-in-seminal-fluid
#8
J Rohayem, E Nieschlag, M Zitzmann, S Kliesch
Patients with Klinefelter's syndrome experience progressive testicular degeneration resulting in impaired endocrine function and azoospermia. What proportion of adolescents develop testosterone deficiency during puberty and how many have spermatozoa in their semen is unclear to date. We aimed to investigate testicular function during puberty and young adulthood in patients with Klinefelter's syndrome and to assess testosterone effects in target tissues. The clinical data of 281 patients with non-mosaic Klinefelter's syndrome aged 10-25 years without previous testosterone replacement were reviewed...
September 9, 2016: Andrology
https://www.readbyqxmd.com/read/27603898/ethnic-and-sex-differences-in-adiponectin-from-childhood-to-adulthood
#9
R Ohman-Hanson, M Cree-Green, M M Kelsey, D H Bessesen, T A Sharp, L Pyle, R I Pereira, K J Nadeau
CONTEXT: Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic vs. Non-Hispanic White (NHW) populations. Adiponectin has a known role in IR and therefore understanding ethnic and sex-specific behavior of adiponectin across the lifespan is of clinical significance. OBJECTIVE: To compare ethnic and sex differences in adiponectin, independent of BMI, across the lifespan and relationship to IR. DESIGN: cross-sectional Setting: primary care, referral center Patients: 187 NHW, 117 H participants (8-57 years) without diabetes...
September 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27600751/longitudinal-effects-of-self-report-pubertal-timing-and-menarcheal-age-on-adolescent-psychological-and-behavioral-outcomes-in-female-youths-from-northern-taiwan
#10
Chih-Ting Lee, Meng-Che Tsai, Chung-Ying Lin, Carol Strong
BACKGROUND: Early puberty is linked to adverse developmental outcomes in adolescents in Western societies. However, little is known about this relationship in an East Asian context. In addition, whether the impact of subjective pubertal timing (PT) and menarcheal age (MA) on adolescent psychosocial development persists into early adulthood remains unclear and is worthy of investigation. METHODS: A subset of data was retrieved from the Taiwan Youth Project, which recruited and followed a longitudinal cohort of 7(th)- and 9(th)-grade female Taiwanese students from 2000 to 2007...
July 26, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27579804/the-effect-of-age-on-elbow-range-of-motion-in-pitchers
#11
Yu-Lin Wang, Hsiao-Yun Chang, Shih-Chung Cheng, Chiang Liu
BACKGROUND: Alteration of elbow range of motion (ROM) has been observed in baseball pitchers. This study aims to compare dominant elbow ROM between early-puberty, late-puberty, and young-adult pitchers. METHODS: We recruited 62 pitchers, consisting of 17 early-puberty (mean age 13.1 years old), 22 late-puberty (mean age 17.7 years old), and 23 young-adult players (mean age 19.4 years old). Dominant elbow ROMs was measured. One-way ANOVA was used to compare the differences in elbow ROM variables between 3 groups...
May 14, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/27573126/hidradenitis-suppurativa-and-the-association-with-hematological-malignancies-a-review-of-2-cases
#12
Bahman Sotoodian, Mariam Abbas, Alain Brassard
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting skin sites with a high density of apocrine glands. HS commonly presents after puberty, with most patients diagnosed in the second decade of their life. Several studies have investigated smoking, obesity, hypertension, diabetes, and dyslipidemia as possible underlying risk factors for HS. However, we encountered 2 patients with a long-standing history of untreated leukemia who developed late-onset HS...
August 29, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27564696/pattern-of-menarche-age-normal-early-and-late-and-its-relationship-with-some-demographic-characteristics-in-girls-and-their-parents
#13
Naeimeh Tayebi, Zahra Yazdznpanahi, Shahrzad Yektatalab, Marzieh Akbarzadeh, Najaf Zare
BACKGROUND: Menarche age is an indicator of a girl's puberty besides the clinical assessment of detecting deviations. This study aimed to search the pattern of menarche age (normal, early and late) and its relationship with some demographic characteristics in girls and their parents. METHODS: This cross-sectional study was done on girls aged between 9 and 18 years old in Shiraz city. About 2000 students were selected through cluster sampling. Data collection was done by applying a demographic information form...
August 26, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27564649/estrogen-stimulation-of-kiss1-expression-in-the-medial-amygdala-involves-estrogen-receptor-%C3%AE-but-not-estrogen-receptor-%C3%AE
#14
Shannon B Z Stephens, Navdeep Chahal, Nagambika Munaganuru, Ruby A Parra, Alexander S Kauffman
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Neurons synthesizing kisspeptin are predominantly located in the hypothalamic anteroventral periventricular (AVPV) and arcuate nuclei, but smaller kisspeptin neuronal populations also reside in extrahypothalamic brain regions, such as the medial amygdala (MeA). In adult rodents, estradiol (E2) increases Kiss1 expression in the MeA, as in the AVPV. However, unlike AVPV and arcuate nuclei kisspeptin neurons, little else is currently known about the development, regulation, and function of MeA Kiss1 neurons...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27559224/adolescent-to-parent-violence-in-adoptive-families
#15
Julie Selwyn, Sarah Meakings
Adolescent-to-parent violence (APV) has received little attention in the social work literature, although it is known to be a factor in families whose children are at risk of entry to care. The behaviour patterns that characterise APV include coercive control, domination and intimidation. Crucially, parental behaviours are compromised by fear of violence. This article discusses the unexpected findings from two recent adoption studies of previously looked after children in England and Wales. The studies exposed the prevalence of APV in the lives of families who had experienced an adoption disruption and those who were finding parenting very challenging...
July 2016: British Journal of Social Work
https://www.readbyqxmd.com/read/27537980/delayed-sleep-phase-disorder-in-a-swedish-cohort-of-adolescents-and-young-adults-prevalence-and-associated-factors
#16
Katarina Danielsson, Agneta Markström, Jan-Erik Broman, Lars von Knorring, Markus Jansson-Fröjmark
A delayed sleep-wake and circadian rhythm often occurs during puberty. While some individuals only develop a delayed sleep phase (DSP), others will fulfill the criteria for the diagnosis of delayed sleep phase disorder (DSPD). All previous studies have however not separated DSP from DSPD, and, as a result, the prevalence and associated factors are largely unknown for the two conditions individually. We estimated the prevalence of DSP and DSPD in a Swedish cohort of adolescents and young adults. We also investigated associated factors in the two conditions relative to each other and individuals with no DSP...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27507005/pubertal-status-pre-meal-drink-composition-and-later-meal-timing-interact-in-determining-children-s-appetite-and-food-intake
#17
Barkha P Patel, Jill K Hamilton, Shirley Vien, Scott G Thomas, G Harvey Anderson
Puberty is a period of development that alters energy intake patterns. However, few studies have examined appetite and food intake (FI) regulation during development of puberty in children and adolescents. Therefore, the objective was to measure the effect of pubertal status on FI and subjective appetite after pre-meal glucose and whey protein drinks in 9- to 14-year-old boys and girls. In a within-subject, randomized, repeated-measures design, children (21 pre-early pubertal, 15 mid-late pubertal) received equally sweetened drinks containing Sucralose (control), glucose, or whey protein (0...
September 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27454175/maternal-age-of-menarche-and-blood-pressure-in-adolescence-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#18
Tsz Chun Lai, Gabriel Matthew Leung, C Mary Schooling
BACKGROUND: Age of puberty has declined substantially in developed settings and is now declining in the rest of the world with economic development. Early age of puberty is associated with non-communicable diseases in adulthood, and may be a long-term driver of population health with effects over generations. In a non-Western setting, we examined the association of maternal age of menarche with blood pressure in late childhood/adolescence. METHODS: We used generalised estimating equations to estimate the adjusted association of maternal age of menarche with age-, sex- and height-adjusted blood pressure z-score from 10 to 16 years in Hong Kong's population-representative birth cohort, "Children of 1997" (n = 8327)...
2016: PloS One
https://www.readbyqxmd.com/read/27403258/dna-fragmentation-and-oxidative-stress-compromise-sperm-motility-and-survival-in-late-pregnancy-exposure-to-omega-9-fatty-acid-in-rats
#19
Oyelowo Oluwakemi, Adegoke Olufeyisipe
OBJECTIVES: The aim of this study was to evaluate the oxidative status and DNA integrity in testes of wistar rat offspring exposed to omega-9 monounsaturated (MUFA) at different times of late organogenesis. MATERIALS AND METHODS: Sixty female rats were divided into six groups of 10 animals. The first group served as control and received the drug vehicle, olive oil (1 ml/kg/day). The second, third, fourth, fifth and sixth group received 1000 mg/kg of oleic acid on gestation day 15 (D15), 16 (D16), 17 (D17), 18 (D18) and 19 (D19), respectively...
May 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27321445/pubertal-development-shapes-perception-of-complex-facial-expressions
#20
Natalie V Motta-Mena, K Suzanne Scherf
We previously hypothesized that pubertal development shapes the emergence of new components of face processing (Scherf et al., 2012; Garcia & Scherf, 2015). Here, we evaluate this hypothesis by investigating emerging perceptual sensitivity to complex versus basic facial expressions across pubertal development. We tested pre-pubescent children (6-8 years), age- and sex-matched adolescents in early and later stages of pubertal development (11-14 years), and sexually mature adults (18-24 years). Using a perceptual staircase procedure, participants made visual discriminations of both socially complex expressions (sexual interest, contempt) that are arguably relevant to emerging peer-oriented relationships of adolescence, and basic (happy, anger) expressions that are important even in early infancy...
June 19, 2016: Developmental Science
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