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Late Puberty

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https://www.readbyqxmd.com/read/29125519/advanced-skeletal-maturity-in-children-and-adolescents-with-myelomeningocele
#1
Ronald Roiz, Nicole M Mueske, Alexander Van Speybroeck, Deirdre D Ryan, Vicente Gilsanz, Tishya A L Wren
PURPOSE: Atypical skeletal development is common in youth with myelomeningocele (MM), though the underlying reasons have not been fully elucidated. This study assessed skeletal maturity in children and adolescents with MM and examined the effects of sex, age, sexual development, ethnicity, anthropometrics and shunt status. METHODS: Forty-three males and 35 females with MM, 6-16 years old, underwent hand radiographs for bone age determination. The difference between bone age and chronological age was evaluated using Wilcoxon sign rank tests...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29121256/malignant-testicular-germ-cell-tumors-in-postpubertal-individuals-with-androgen-insensitivity-prevalence-pathology-and-relevance-of-single-nucleotide-polymorphism-based-susceptibility-profiling
#2
M Cools, K P Wolffenbuttel, R Hersmus, B B Mendonca, J Kaprová, S L S Drop, H Stoop, A J M Gillis, J W Oosterhuis, E M F Costa, S Domenice, M Y Nishi, L Wunsch, C A Quigley, G T'Sjoen, L H J Looijenga
STUDY QUESTION: What is the prevalence of malignant testicular germ cell tumors (TGCT) and its precursors, (pre-) germ cell neoplasia in situ (GCNIS), in late teenagers and adults who have androgen insensitivity syndrome (AIS) and the impact of an individual's genetic susceptibility to development of TGCT? SUMMARY ANSWER: No GCNIS or TGCT was diagnosed, but pre-GCNIS was identified in 14 and 10% of complete and partial AIS patients, respectively, and was associated with a higher genetic susceptibility score (GSS), with special attention for KITLG (rs995030) and ATFZIP (rs2900333)...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29118987/massive-adrenal-incidentalomas-and-late-diagnosis-of-congenital-adrenal-hyperplasia-in-prostate-cancer
#3
Xin Feng, Gregory Kline
In a 61-year-old Caucasian male with prostate cancer, leuprolide and bicalutamide failed to suppress the androgens. He presented to endocrinology with persistently normal testosterone and incidental massive (up to 18 cm) bilateral adrenal myelolipomas on CT scan. Blood test did not reveal metanephrine excess. The patient was noted to have short stature (151 cm) and primary infertility. Elementary school photographs demonstrated precocious puberty. Physical examination revealed palpable abdominal (adrenal) masses...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29112888/age-of-pubertal-onset-and-2nd-to-4th-digit-ratios-preliminary-findings
#4
Diane C Gooding, Blake H Chambers
BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The aim of this study was to evaluate the possible relation between digit ratio and age of pubertal onset. METHODS: Participants were 321 men and 202 women aged between 18 and 28 at the time of assessment who self-reported their onset of puberty (i.e., age at first conscious ejaculation or menarche). Participants' right and left digit lengths were measured from hand scans...
November 4, 2017: Early Human Development
https://www.readbyqxmd.com/read/29108060/effect-of-dried-distiller-s-grains-plus-solubles-in-postpartum-diets-of-beef-cows-on-reproductive-performance-of-dam-and-heifer-progeny
#5
E G Taylor, R P Lemenager, V Fellner, K R Stewart
Forty-eight primiparous and multiparous cows were fed a silage-based total mixed ration (TMR; CON), a TMR with 2.5 kg/d DM dried distiller's grains plus solubles (DDGS; MID), or a TMR with 4.7 kg/d DM DDGS (HIGH) from 8.5 ± 4 to 116 ± 4 d postpartum (DPP). All diets were formulated to be isocaloric for a postpartum ADG targeted at 0.22 kg, whereas CP exceeded requirements in both diets containing DDGS. Blood samples were collected from dams at 7- and 21-d intervals for progesterone concentration (resumption of cyclicity) and plasma urea nitrogen, respectively...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29101351/programmed-cell-senescence-in-skeleton-during-late-puberty
#6
Changjun Li, Yu Chai, Lei Wang, Bo Gao, Hao Chen, Peisong Gao, Feng-Quan Zhou, Xianghang Luo, Janet L Crane, Bin Yu, Xu Cao, Mei Wan
Mesenchymal stem/progenitor cells (MSPCs) undergo rapid self-renewal and differentiation, contributing to fast skeletal growth during childhood and puberty. It remains unclear whether these cells change their properties during late puberty to young adulthood, when bone growth and accrual decelerate. Here we show that MSPCs in primary spongiosa of long bone in mice at late puberty undergo normal programmed senescence, characterized by loss of nestin expression. MSPC senescence is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste homolog 2 (Ezh2) and its trimethylation of histone H3 on Lysine 27 (H3K27me3) mark...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098175/inhibiting-production-of-new-brain-cells-during-puberty-or-adulthood-blunts-the-hormonally-induced-surge-of-luteinizing-hormone-in-female-rats
#7
Margaret A Mohr, Lydia L DonCarlos, Cheryl L Sisk
New cells are added during both puberty and adulthood to hypothalamic regions that govern reproduction, homeostasis, and social behaviors, yet the functions of these late-born cells remain elusive. Here, we pharmacologically inhibited cell proliferation in ventricular zones during puberty or in adulthood and determined subsequent effects on the hormone-induced surge of luteinizing hormone (LH) in female rats. Initial neuroanatomical analyses focused on verifying incorporation, activation, and pharmacological inhibition of pubertally or adult born cells in the anteroventral periventricular nucleus (AVPV) of the hypothalamus because of the essential role of the AVPV in triggering the preovulatory LH surge in females...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29072404/knowledge-and-perceptions-of-common-breast-cancer-risk-factors-in-northern-saudi-arabia
#8
Ali Ghannam Alrashidi, Hussain Gadelkarim Ahmed, Kalaf Jaze Kalaf Alshammeri, Sami Awejan Alrashedi, Bassam Ahmed ALmutlaq, Fayez Nashi Motlaq Alshammari, Abdulaziz Abdulrahman Hamad Alshudayyid, Abdulrahman Ayed Jazza Alshammari, Fahad Mohammed Samran Anazi, Wasmiah Marzouq Alshammari, Hamdan Sulaiman Ayed Alshammari, Eid Fahad Habeeb Alshammari
Background: Breast cancer is the second leading cause of cancer death in women around the world. The degree of adoption of a preventive lifestyle offers valuable information for planning appropriate intervention programs for improving women’s health. The objective of the present study was to assess the levels of breast cancer related knowledge among a Northern Saudi population. Methodology: In this cross sectional study, data were obtained from 566 Saudi volunteers living in the city of Hail, the Kingdom of Saudi Arabia (KSA)...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29031946/spermatozoa-dna-methylation-patterns-differ-due-to-peripubertal-age-in-bulls
#9
Simon Lambert, Patrick Blondin, Christian Vigneault, Rémi Labrecque, Isabelle Dufort, Marc-André Sirard
In the dairy industry, using semen as soon as the bull is mature enough to produce it is advantageous for breeding purposes. Mammalian spermatogenesis is a hormone-dependent developmental program in which a complex cascade of events must take place to ensure that germ cells reach the proper stage of development at the proper time. Conventional indicators of semen quality such as sperm cell motility and viability usually improve as bulls mature, meeting quality criteria satisfactorily at around 16 months. Using semen before that age may affect embryo viability, but other changes occurring during the peripubertal period should be considered...
October 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/29025205/diurnal-variation-of-gonadotropin-levels-in-girls-with-early-stages-of-puberty
#10
Yu Sun Kang, Dong-Yoon Yoo, In Hyuk Chung, Eun-Gyong Yoo
PURPOSE: Pubertal gonadotropin secretion shows circadian pattern and the luteinizing hormone (LH) levels tend to rise in later stages of puberty in girls. We studied the usefulness of basal LH in the evaluation of central precocious puberty with emphasis on the influence of sampling time. METHODS: Medical records of 334 girls that underwent gonadotropin-releasing hormone stimulation test (GnRHST) were reviewed. Auxological and laboratory data were compared between those with early morning (EM, before 10 AM) and late morning/afternoon (LM/A, after 10 AM) basal samples...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28992028/genomics-symposium-using-genomic-approaches-to-uncover-sources-of-variation-in-age-at-puberty-and-reproductive-longevity-in-sows
#11
H R Wijesena, C A Lents, J-J Riethoven, M D Trenhaile-Grannemann, J F Thorson, B N Keel, P S Miller, M L Spangler, S D Kachman, D C Ciobanu
Genetic variants associated with traits such as age at puberty and litter size could provide insight into the underlying genetic sources of variation impacting sow reproductive longevity and productivity. Genomewide characterization and gene expression profiling were used using gilts from the University of Nebraska-Lincoln swine resource population ( = 1,644) to identify genetic variants associated with age at puberty and litter size traits. From all reproductive traits studied, the largest fraction of phenotypic variation explained by the Porcine SNP60 BeadArray was for age at puberty (27...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28989027/hyperglycemic-condition-during-puberty-increases-collagen-fibers-deposition-in-the-prostatic-stroma-and-reduces-mmp-2-activity
#12
Sérgio Alexandre Alcantara Dos Santos, Elaine Manoela Porto Amorim, Larissa Mayume Ribeiro, Jaqueline Carvalho Rinaldi, Flávia Karina Delella, Luis Antonio Justulin, Sérgio Luis Felisbino
Puberty is an important period for the growth and maturation of the male reproductive system, and is also a critical window for endocrine or environmental interference. The physiological levels of circulating insulin and hyperglycemic control are important factors for a normal prostate growth. Hyperglycemia during puberty is reported to retard the growth of the prostate gland, with remarkable effects on the epithelial compartment. Here, we investigated the impact of hyperglycemia along with a simultaneous or late insulin replacement on the ventral prostate growth in rats during puberty, paying special attention to the deposition of collagen fibers and activities of gelatinase, matrix metalloproteinase-2 (MMP-2), and -9 (MMP-9)...
December 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28961710/the-age-variable-in-childhood-concussion-management-a-systematic-review
#13
Rosemarie Scolaro Moser, Gavin A Davis, Philip Schatz
Background: Sports-related concussion in young children has become a significant international public health issue. This paper reviews the research literature in an effort to shed light on the question, "At what age should young children be managed differently than adults or older adolescents?" Method: A systematic review, registered with PROSPERO and using PRISMA guidelines, was conducted rendering 37 sports concussion original research studies that examined age as a variable (5-18 years), and which met specific inclusion/exclusion criteria...
August 31, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28951134/implications-of-pubertal-timing-for-romantic-relationship-quality-among-heterosexual-and-sexual-minority-young-adults
#14
Bianka M Reese, Sarah L Trinh, Carolyn T Halpern
PURPOSE: Relative to on-time or late-maturing peers, girls who begin puberty early typically begin romantic and sexual experiences earlier; however, advanced pubertal status does not necessarily coincide with commensurate interpersonal skills necessary for healthy romantic relationships. Research is limited on the long-term implications of early puberty for relationship quality, and virtually nothing is known about the social implications of early timing for sexual minority females. METHODS: Using linear regression, we examine longitudinal associations between two measures of girls' pubertal timing (self-perceived timing and menarcheal age) and romantic relationship quality in young adulthood, stratified by sexual orientation, among 5,568 females in waves I and IV of the National Longitudinal Study of Adolescent to Adult Health...
September 23, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28931963/-when-you-re-a-baby-you-don-t-have-puberty-understanding-of-puberty-and-human-reproduction-in-late-childhood-and-early-adolescence
#15
Lisa B Hurwitz, Alexis R Lauricella, Brianna Hightower, Iris Sroka, Teresa K Woodruff, Ellen Wartella
Basic knowledge of human reproduction can help youth prepare for puberty and make later classes focused on advanced reproductive health topics manageable. With the intention of potentially informing the creation of learning materials, we conducted a needs assessment among children ages 7 to 12 in our suburban Chicago community to ascertain their current understanding of, and beliefs and misconceptions about, human reproduction, and to determine their needs for additional reproductive health education. We held qualitative focus group interviews with local children...
August 2017: Journal of Early Adolescence
https://www.readbyqxmd.com/read/28926843/the-genetic-basis-of-delayed-puberty
#16
S R Howard, Leo Dunkel
<br>The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Some insights into the genetic mutations that lead to familial DP have come from sequencing genes known to cause GnRH deficiency, most recently via next generation sequencing, and others from large-scale genome wide association studies in the general population...
September 18, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28924487/a-novel-stop-mutation-p-gln22-of-dax1-nr0b1-results-in-late-onset-x-linked-adrenal-hypoplasia-congenita
#17
Judith Gerards, Michael M Ritter, Elke Kaminsky, Andreas Gal, Wolfgang Hoeppner, Marcus Quinkler
DAX1 (NR0B1) is an orphan nuclear receptor, which plays an important role in development and function of the adrenal glands and gonads. Mutations in DAX1 cause X-linked adrenal hypoplasia congenita (X-linked AHC), which is characterized by adrenal insufficiency (AI) and hypogonadotropic hypogonadism (HHG). Affected boys present with adrenal failure usually in childhood and, later in life, with delayed puberty. However, patients with a late-onset form of X-linked AHC have also been described in the past years...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28919976/impacts-of-prenatal-nutrition-on-animal-production-and-performance-a-focus-on-growth-and-metabolic-and-endocrine-function-in-sheep
#18
REVIEW
Prabhat Khanal, Mette Olaf Nielsen
The concept of foetal programming (FP) originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been evaluated in various animal models to gain further insights into the mechanisms underlying the foetal origins of health and disease in humans. In FP research, the sheep has been quite extensively used as a model for humans. In this paper we will review findings mainly from our Copenhagen sheep model, on the implications of late gestation malnutrition for growth, development, and metabolic and endocrine functions later in life, and discuss how these implications may depend on the diet fed to the animal in early postnatal life...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28882815/childhood-tolerance-of-severe-influenza-a-mortality-analysis-in-mice
#19
Freeman Suber, Lester Kobzik
During the 1918 influenza pandemic, children experienced substantially lower mortality than adults, a striking but unexplained finding. Whether this was due to enhanced resistance (reduced virus load) or better tolerance (reduced impact of infection) has not been defined. We found that prepubertal mice infected with H1N1 influenza virus also showed greater survival than infected pubertal mice, despite similar virus loads. Transcriptome profiling of infected lungs identified estrogen as a regulator of susceptibility in both sexes, and also linked better survival to late expression of IL-1beta...
September 7, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28873088/identifying-genetic-variants-that-affect-viability-in-large-cohorts
#20
Hakhamanesh Mostafavi, Tomaz Berisa, Felix R Day, John R B Perry, Molly Przeworski, Joseph K Pickrell
A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of genetic variants, currently influence viability. The approach consists in testing whether the frequency of an allele varies across ages, accounting for variation in ancestry. We applied it to the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort and to the parents of participants in the UK Biobank...
September 2017: PLoS Biology
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