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Late Menarche

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https://www.readbyqxmd.com/read/29699536/prevalence-and-associated-factors-of-dysmenorrhea-among-secondary-and-preparatory-school-students-in-debremarkos-town-north-west-ethiopia
#1
Abebaw Abeje Muluneh, Tewodros Seyuom Nigussie, Kahsay Zenebe Gebreslasie, Kiber Temesgen Anteneh, Zemenu Yohannes Kassa
BACKGROUND: Dysmenorrhea is one of the most common gynecologic disorders and a frequently observed cause of anxiety and discomfort among female adolescents. Its prevalence varies between 16% and 91% in women of reproductive age. Its population statistics are too scant in Ethiopia. This study was aimed to determine the prevalence and associated factors of dysmenorrhea among secondary and preparatory school students in Debremarkos town, 2016. METHODS: Institutional based cross-sectional study was employed from Sept...
April 24, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29682210/age-at-menarche-and-risks-of-gestational-diabetes-mellitus-a-meta-analysis-of-prospective-studies
#2
Ya Xiao, Ruixue Chen, Minghao Chen, Anling Luo, Dayi Chen, Qiuer Liang, Yunfei Cai, Liguo Chen, Xiaoshan Zhao
Background: Accumulating evidence suggests that early menarche is associated with adult obesity, which in turn may increase the risk of insulin resistance and hyperglycemia. However, the relation of menarcheal age with gestational diabetes mellitus (GDM) remains inconsistent across studies. The objective of this meta-analysis was to evaluate the association between age at menarche and GDM risk. Materials and Methods: We searched Medline (PubMed), Embase, Web of Knowledge and the Cochrane library through the end of May 2017...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29673014/association-of-primary-dysmenorrhea-with-anthropometrical-and-socio-economic-factors-in-polish-university-students
#3
Martyna Zurawiecka, Iwona Wronka
AIMS: To examine the prevalence and factors correlated with primary dysmenorrhea in young female subjects. METHODS: Cross-sectional research was conducted among 1305 female university students aged 19-25 years. The following measurements were taken: height, body mass, waist circumference, hip circumference, the length of index and ring finger. A questionnaire was used to obtain information on menstrual pains, the characteristics of the menstrual cycles (regularity, duration), the number of the days of menstrual bleeding, age at menarche, overall health and socio-economic status of the subjects...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29668705/age-at-natural-menopause-and-associated-factors-in-adult-women-findings-from-the-china-kadoorie-biobank-study-in-zhejiang-rural-area
#4
Meng Wang, Wei-Wei Gong, Ru-Ying Hu, Hao Wang, Yu Guo, Zheng Bian, Jun Lv, Zheng-Ming Chen, Li-Ming Li, Min Yu
OBJECTIVES: To investigate the factors associated with age at natural menopause in a large population of Chinese adult women. METHODS: This cross-sectional study was part of the baseline survey of China Kadoorie Biobank in Zhejiang Province. A total of 17,076 postmenopausal women were included in the present study. Relevant data of socio-demographic, lifestyle, dietary and reproductive characteristics were collected. Multinomial logistic regression models were used to examine the associated factors of age at natural menopause with adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were reported...
2018: PloS One
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#5
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29558518/risk-factors-for-type-2-diabetes-mellitus-an-exposure-wide-umbrella-review-of-meta-analyses
#6
Vanesa Bellou, Lazaros Belbasis, Ioanna Tzoulaki, Evangelos Evangelou
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed. METHODS: We searched PubMed to capture all meta-analyses and Mendelian randomization studies for risk factors of T2DM. For each association, we estimated the summary effect size, its 95% confidence and prediction interval, and the I2 metric...
2018: PloS One
https://www.readbyqxmd.com/read/29547736/the-presence-of-kras-ppp2r1a-and-arid1a-mutations-in-101-chinese-samples-with-ovarian-endometriosis
#7
Yang Zou, Jiang-Yan Zhou, Jiu-Bai Guo, Li-Qun Wang, Yong Luo, Zi-Yu Zhang, Fa-Ying Liu, Jun Tan, Feng Wang, Ou-Ping Huang
Endometriosis is a potential premalignant disorder. The underlying molecular aberrations, however, are not fully understood. A recent exome sequencing study found that 25% (10/39) of deep infiltrating endometriosis harbored cancer driver gene mutations. However, it is unclear whether these mutations also exist in ovarian endometriosis. Here, a total of 101 ovarian endometriosis samples were analyzed for the presence of these gene mutations, including KRAS, PPP2R1A, PIK3CA and ARID1A. In addition, 6 other cancer-associated genes (BRAF, NRAS, HRAS, ERK1, ERK2 and PTEN) were also analyzed...
March 9, 2018: Mutation Research
https://www.readbyqxmd.com/read/29531580/histopathological-pattern-and-age-distribution-of-malignant-ovarian-tumor-among-sudanese-ladies
#8
Sumeya A Kheiri, Abdelillah Kunna, Ali Yousif Babiker, Sultan A Alsuhaibani, Rami Yousif Ahmed, Mohamed Alkhatim Alsammani
INTRODUCTION: Ovarian cancer is the cause of a high case-fatality ratio, and most of the cases are diagnosed in late stages. OBJECTIVES: To determine the histopathological types, age distribution, and ovarian tumour stages among diagnosed with ovarian cancer at Al - Amal Tower a multi-referral polyclinic of Radiology & Isotope Center Khartoum (RICK), Sudan. METHODS: All histopathology reports patients' case from January to June 2015 were reviewed...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29499227/low-digit-ratio-2d-4d-and-late-pubertal-onset-indicate-prenatal-hyperandrogenziation-in-alcohol-binge-drinking
#9
Bernd Lenz, Polyxeni Bouna-Pyrrou, Christiane Mühle, Johannes Kornhuber
BACKGROUND: Alcohol binge drinking behavior is an important public health issue. Causal rodent and human associational studies show that reinforcement of prenatal androgen signaling increases alcohol consumption in adulthood. However, the effects of prenatal androgen exposure on adult binge drinking patterns have not been investigated yet. METHOD: We analyzed data from 2225 participants of an online survey (conducted 06-07/2016) to evaluate biomarkers for prenatal androgen exposure (second-to-fourth finger length ratio [2D:4D], age at spermarche or menarche as hallmark for pubertal onset) in binge drinking (≥1 episode of 15+, 10+, and/or 5+ standard drinks of ~13 g of alcohol within 2 h during the 24 month- and 2 week-recall periods)...
February 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29489847/reproductive-period-endogenous-estrogen-exposure-and-dementia-incidence-among-women-in-latin-america-and-china-a-10-66-population-based-cohort-study
#10
Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Kia-Chong Chua, Michael E Dewey, Zhaorui Liu, Rosie Mayston, Adolfo Valhuerdi
BACKGROUND: Exposure to endogenous estrogen may protect against dementia, but evidence remains equivocal. Such effects may be assessed more precisely in settings where exogenous estrogen administration is rare. We aimed to determine whether reproductive period (menarche to menopause), and other indicators of endogenous estrogen exposure are inversely associated with dementia incidence. METHODS: Population-based cohort studies of women aged 65 years and over in urban sites in Cuba, Dominican Republic, Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China...
2018: PloS One
https://www.readbyqxmd.com/read/29475798/-pubertal-growth-of-1-453-healthy-children-according-to-age-at-pubertal-growth-spurt-onset-the-barcelona-longitudinal-growth-study
#11
Antonio Carrascosa, Diego Yeste, Antonio Moreno-Galdó, Miquel Gussinyé, Ángel Ferrández, María Clemente, Mónica Fernández-Cancio
INTRODUCTION: Pubertal growth pattern differs according to age at pubertal growth spurt onset which occurs over a five years period (girls: 8-13 years, boys: 10-15 years). The need for more than one pubertal reference pattern has been proposed. We aimed to obtain five 1-year-age-interval pubertal patterns. SUBJECTS AND METHODS: Longitudinal (6 years of age-adult height) growth study of 1,453 healthy children to evaluate height-for-age, growth velocity-for-age and weight-for-age values...
February 20, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29472893/late-onset-puberty-induction-by-transdermal-estrogen-in-turner-syndrome-girls-a-longitudinal-study
#12
Aneta Monika Gawlik, Magdalena Hankus, Kamila Szeliga, Aleksandra Antosz, Tomasz Gawlik, Kamil Soltysik, Agnieszka Drosdzol-Cop, Krzysztof Wilk, Grzegorz Kudela, Tomasz Koszutski, Ewa Malecka-Tendera
Objective: Estrogen replacement therapy (ERT) for Turner syndrome (TS) is a widely discussed topic; however, the optimal model of ERT for patients with delayed diagnosis and/or initiation of therapy is still unclear, mainly due to insufficient data. We present the results of a prospective observational single-center study in which the efficacy of late-onset puberty induction by one-regimen transdermal ERT in TS girls was evaluated. Methods: The analysis encompassed 49 TS girls (63...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29404275/oncogenic-viruses-and-breast-cancer-mouse-mammary-tumor-virus-mmtv-bovine-leukemia-virus-blv-human-papilloma-virus-hpv-and-epstein-barr-virus-ebv
#13
REVIEW
James S Lawson, Brian Salmons, Wendy K Glenn
Background: Although the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown. The development of substantial recent evidence indicates that a handful of viruses may have a role in breast cancer. These viruses are mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma viruses (HPVs), and Epstein-Barr virus (EBV-also known as human herpes virus type 4)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29373907/knowledge-and-practices-related-to-screening-for-breast-cancer-among-women-in-delhi-india
#14
Neha Dahiya, Saurav Basu, Megha Chandra Singh, Suneela Garg, Rajesh Kumar, Charu Kohli
Background: Breast cancer is a major public health problem globally. The ongoing epidemiological, socio-cultural and demographic transition by accentuating the associated risk factors has disproportionately increased the incidence of breast cancer cases and resulting mortality in developing countries like India. Early diagnosis with rapid initiation of treatment reduces breast cancer mortality. Therefore awareness of breast cancer risk and a willingness to undergo screening are essential. The objective of the present study was to assess the knowledge and practices relating to screening for breast cancer among women in Delhi...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29300925/progesterone-mediated-inhibition-of-the-gnrh-pulse-generator-differential-sensitivity-as-a-function-of-sleep-status
#15
Su Hee Kim, Jessica A Lundgren, Ruchi Bhabhra, Jessicah S Collins, James T Patrie, Christine M Burt Solorzano, John C Marshall, Christopher R McCartney
Context: During normal, early puberty, luteinizing hormone (LH) pulse frequency is low while awake but increases during sleep. Mechanisms underlying such changes are unclear, but a small study in early pubertal girls suggested that differential wake-sleep sensitivity to progesterone negative feedback plays a role. Objective: To test the hypothesis that progesterone acutely reduces waking LH pulse frequency more than sleep-associated pulse frequency in late pubertal girls...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29214820/weight-management-behaviors-among-mexican-american-youth-cross-sectional-variation-by-timing-of-growth-and-maturation
#16
Jennifer L Gay, Eva V Monsma, Katie Darby Hein
PURPOSE: To assess the association between growth and maturation with weight management behaviors (WMBs) among Mexican American youth. DESIGN: A cross-sectional design was used to measure timing of growth and maturation as well as WMBs. SAMPLE: Students were recruited through physical education classes in south Texas schools. The sample included 623 participants (52.3% female; 49.8% with weight ≥85th percentile) in grades 4 through 12. Students in middle school were purposely oversampled to examine questions around timing of growth and maturation...
February 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#17
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
January 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29112888/age-of-pubertal-onset-and-2nd-to-4th-digit-ratios-preliminary-findings
#18
Diane C Gooding, Blake H Chambers
BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The aim of this study was to evaluate the possible relation between digit ratio and age of pubertal onset. METHODS: Participants were 321 men and 202 women aged between 18 and 28 at the time of assessment who self-reported their onset of puberty (i.e., age at first conscious ejaculation or menarche). Participants' right and left digit lengths were measured from hand scans...
January 2018: Early Human Development
https://www.readbyqxmd.com/read/29112597/association-of-age-at-menarche-with-obesity-and-hypertension-among-southwestern-chinese-women-a-new-finding
#19
Gang Liu, Yuan Yang, Wei Huang, Nan Zhang, Fan Zhang, Ge Li, Han Lei
OBJECTIVES: The purpose of this study was to assess the association of the age at menarche with obesity and hypertension among southwestern Chinese women. METHODS: Participants in a cross-sectional study were required to recall and complete a standard self-reporting questionnaire, including age at menarche and lifestyle habits. Cardiovascular risk factors were obtained from the questionnaire or a physical examination. The main outcomes were obesity and hypertension...
November 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28970852/clinicopathologic-characteristics-of-pregnancy-associated-breast-cancer-results-of-analysis-of-a-nationwide-breast-cancer-registry-database
#20
Yun Gyoung Kim, Ye Won Jeon, Byung Kyun Ko, Guiyun Sohn, Eun-Kyu Kim, Byung-In Moon, Hyun Jo Youn, Hyun-Ah Kim
PURPOSE: This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC). METHODS: A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ , invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child...
September 2017: Journal of Breast Cancer
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