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Late Menarche

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https://www.readbyqxmd.com/read/28610407/lack-of-hpv-in-benign-and-malignant-epithelial-ovarian-tumors-in-iran
#1
Farah Farzaneh, Seyed Alireza Nadji, Donya Khosravi, Maryam Sadat Hosseini, Mohammad Hashemi Bahremani, Mohammad Chehrazi, Ghazal Bagheri, Afsaneh Sigaroodi, Zahra Haghighatian
Background: Ovarian epithelial tumors one of the most common gynecological neoplasms; we here evaluated the presence of HPV in benign and malignant examples. Methods: In this cross-sectional study the records of 105 patients with epithelial ovarian tumors (benign and malignant) referred to Imam Hossein University Hospital from 2012 to 2015 were evaluated along with assessment of the presence of the HPV infection using PCR. Results: Among 105 patients, comprising 26 (24.8%) with malignant and 79 (75.2%) with benign lesions, the factors found to impact on malignancy were age at diagnosis, age at first pregnancy, number of pregnancies and hormonal status...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28603694/estrogen-effects-on-the-mammary-gland-in-early-and-late-life-and-breast-cancer-risk
#2
REVIEW
Genevieve Victoria Dall, Kara Louise Britt
A woman has an increased risk of breast cancer if her lifelong estrogen exposure is increased due to an early menarche, a late menopause, and/or an absence of childbearing. For decades, it was presumed that the number of years of exposure drove the increased risk, however, recent epidemiological data have shown that early life exposure (young menarche) has a more significant effect on cancer risk than late menopause. Thus, rather than the overall exposure it seems that the timing of hormone exposure plays a major role in defining breast cancer risk...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28581683/the-effect-of-early-pregnancy-on-the-formation-of-obstetric-fistula
#3
Andrew Browning, Frederick Mbise, Phil Foden
OBJECTIVE: To assess the effect of early pregnancy on obstetric fistula. METHODS: A prospective observational study was conducted among patients with obstetric fistula caused by a long obstructed labor who presented at Selian Lutheran Hospital, Tanzania, or Kitovu Hospital, Uganda, between January 1, 2015, and January 31, 2016. Demographic and clinical variables were evaluated. RESULTS: Among 270 patients, 162 (60.0%) experienced their first pregnancy up to 2 years after menarche (early group) and 108 (40...
June 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28520646/relationship-between-pubertal-timing-and-chronic-nonspecific-pain-in-adolescent-girls-the-young-hunt3-study-2006-2008
#4
Barbro Kløven, Gry B Hoftun, Pål R Romundstad, Marite Rygg
The aim of this study was to examine a possible relationship between early puberty and chronic nonspecific pain in 13- to 18-year-old girls. All adolescents in Nord-Trøndelag County, Norway, were invited to participate in the Young-HUNT3 study (2006-2008). Of the invited girls, 81% answered the questionnaire and of these 3982 were 13 to 18 years of age. Menarche and perceived physical maturation were used as exposure measures. Early menarche was defined as <12 years, normal menarche as ≥12 and <14 years, and late menarche as ≥14 years...
May 16, 2017: Pain
https://www.readbyqxmd.com/read/28495176/pubertal-timing-and-cardiometabolic-markers-at-age-16-years
#5
Nina E Berentzen, Alet H Wijga, Lenie van Rossem, Dirkje S Postma, Ulrike Gehring, Henriëtte A Smit
OBJECTIVE: To examine the association between pubertal timing and cardiometabolic markers among adolescents. STUDY DESIGN: We used data from Dutch adolescents participating in a birth cohort study. The study population for the current study consisted of 799 adolescents of whom data were available for at least 1 of the exposure variables (pubertal timing and/or age at menarche) and any of the cardiometabolic markers (waist circumference, cholesterol, blood pressure [BP], glycated hemoglobin) measured at age 16 years...
May 8, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28486542/association-between-menarche-and-iron-deficiency-in-non-anemic-young-women
#6
Deepa L Sekhar, Laura E Murray-Kolb, Allen R Kunselman, Carol S Weisman, Ian M Paul
BACKGROUND: The prevalence of iron deficiency (ID) among non-pregnant, reproductive-age US women significantly exceeds rates among males. In clinical practice ID screening relies on hemoglobin, a late-stage indicator of ID. As a single, low-cost laboratory test to diagnose ID before anemia develops is lacking, the study objective was to improve ID screening by identifying risk factors among non-anemic, iron-deficient reproductive age women. METHODS: Cross-sectional data were from the National Health and Nutrition Examination Survey (NHANES) 2003-2010...
2017: PloS One
https://www.readbyqxmd.com/read/28395581/a-case-control-study-of-rheumatoid-arthritis-revealed-abdominal-obesity-and-environmental-risk-factor-interactions-in-northern-china
#7
Lingyu Fu, Jianming Zhang, Lei Jin, Yao Zhang, Saisai Cui, Meng Chen
BACKGROUND: The aim of this study was to evaluate new and previously hypothesized environmental risk factors and their interaction with rheumatoid arthritis (RA). METHODS: Four hundred patients recently diagnosed with RA and 400 controls frequency-matched by gender and birth year using Propensity Score Matching (PSM) were selected from northern China. Investigation was performed using self-reported data from interviewer-administered surveys. Associations between exposure variables and risk of RA were evaluated using multifactor non-conditional logistic regression...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28366409/demographic-lifestyle-and-other-factors-in-relation-to-antim%C3%A3-llerian-hormone-levels-in-mostly-late-premenopausal-women
#8
MULTICENTER STUDY
Seungyoun Jung, Naomi Allen, Alan A Arslan, Laura Baglietto, Louise A Brinton, Brian L Egleston, Roni Falk, Renée T Fortner, Kathy J Helzlsouer, Annika Idahl, Rudolph Kaaks, Eva Lundin, Melissa Merritt, Charlotte Onland-Moret, Sabina Rinaldi, María-José Sánchez, Sabina Sieri, Helena Schock, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Ruth C Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley Tworoger, Kala Visvanathan, Vittorio Krogh, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F Dorgan
OBJECTIVE: To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 671 premenopausal women not known to have cancer. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28362019/non-genetic-risk-factors-for-early-and-late-age-at-menarche-in-eastern-ukrainian-females
#9
Anna Yermachenko, Iryna Mogilevkina, Vitaliy G Gurianov, Olena Getsko, Volodymyr Dvornyk
BACKGROUND: Age at menarche is a reproductive trait, which is largely influenced by environmental factors. Each population has a set of lifestyle factors that may shift age at menarche in different direction. Populations of Eastern Slavs, particularly Ukrainians, are underrepresented in studies of reproductive health. The objective of the present research was to determine important non-genetic risk factors, which may contribute to menarcheal onset in Eastern Ukrainians. METHODS: In total 620 females aged 17-25 years participated in the cross-sectional survey...
April 1, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28350418/hymen-imperforatus-%C3%A3-r-en-diagnos-som-ofta-missas-risk-f%C3%A3-r-l%C3%A3-ngdragna-symtom-om-adekvat-unders%C3%A3-kning-inte-genomf%C3%A3-rs
#10
Martin Salö, Anna Börjesson
Imperforate hymen - an often missed diagnosis Imperforate hymen is the most common congenital malformation in the female reproduction system that give rise to obstructive symptoms. If the diagnosis is not made in the newborn girl, symptoms often first arise at menarche. The diagnosis is easy to make but has to be suspected. This case reports describes the typical clinical picture of a late diagnosed imperforate hymen. As shown in this case and from a review of the literature, these girls often have symptoms for a long time before the diagnosis is made...
March 23, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28338576/genetic-polymorphism-of-nucks1-is-associated-with-the-susceptibility-of-adolescent-idiopathic-scoliosis
#11
Leilei Xu, Chao Xia, Weixiang Sun, Xiaodong Qin, Yong Qiu, Zezhang Zhu
STUDY DESIGN: A genetic association study. OBJECTIVE: To investigate whether NUCKS1 is a susceptible gene of adolescent idiopathic scoliosis (AIS) in Chinese population and to further narrate its association with the clinical phenotypes. SUMMARY OF BACKGROUND DATA: AIS is characterized by late onset of menarche and disturbed growth rhythm. Previous studies showed that NUCKS1 is associated with age at menarche and pubertal height growth. METHODS: SNP rs951366 of NUCKS1 was genotyped in 972 patients and 1454 healthy controls...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28293690/bone-mineral-density-among-korean-females-aged-20-50%C3%A2-years-influence-of-age-at-menarche-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#12
H K Chang, D-G Chang, J-P Myong, J-H Kim, S-J Lee, Y S Lee, H-N Lee, K H Lee, D C Park, C J Kim, S Y Hur, J S Park, T C Park
To evaluate a possible correlation between bone mineral density (BMD) and age at menarche, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey IV-V (KNHANES IV-V). Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20-50 years. INTRODUCTION: To investigate any correlation between bone mineral density (BMD) and age at menarche in Korean females using data from the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-V; 2008-2011)...
March 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28264686/reproductive-risk-factors-associated-with-breast-cancer-in-women-in-bangui-a-case-control-study
#13
Augustin Balekouzou, Ping Yin, Christian Maucler Pamatika, Cavin Epie Bekolo, Sylvain Wilfrid Nambei, Marceline Djeintote, Komlan Kota, Christian Diamont Mossoro-Kpinde, Chang Shu, Minghui Yin, Zhen Fu, Tingting Qing, Mingming Yan, Jianyuan Zhang, Shaojun Chen, Hongyu Li, Zhongyu Xu, Boniface Koffi
BACKGROUND: Breast cancer (breast Ca) is recognised as a major public health problem in the world. Data on reproductive factors associated with breast Ca in the Central African Republic (CAR) is very limited. This study aimed to identify reproductive variables as risk factors for breast Ca in CAR women. METHODS: A case-control study was conducted among 174 cases of breast Ca confirmed at the Pathology Unit of the National Laboratory in Bangui between 2003 and 2015 and 348 age-matched controls...
March 6, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28182101/periductal-mastitis-an-inflammatory-disease-related-to-bacterial-infection-and-consequent-immune-responses
#14
Lu Liu, Fei Zhou, Pin Wang, Lixiang Yu, Zhongbing Ma, Yuyang Li, Dezong Gao, Qiang Zhang, Liang Li, Zhigang Yu
Periductal mastitis (PDM) is a prolonged inflammatory disease, but the cause of PDM is poorly understood. In the present case control study, 87 PDM and 87 healthy controls were enrolled and the results were evaluated to identify the significant risk factors for PDM. To investigate the roles of bacterial infection and critical cytokines expression, 16S rRNA gene sequencing and bacterial culturing were conducted. We also measured the levels of interferon-γ, interleukin-12A, and interleukin-17A by semiquantitative immunohistochemistry method...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28142040/bmi-reproductive-factors-and-breast-cancer-molecular-subtypes-a-case-control-study-and-meta-analysis
#15
Hui Li, Xuezheng Sun, Erline Miller, Qiong Wang, Ping Tao, Li Liu, Ying Zhao, Mengjie Wang, Yana Qi, Jiayuan Li
BACKGROUND: The effects of body mass index (BMI) and reproductive factors may vary among breast cancer molecular subtypes, evidence of which is lacking in East Asia. METHODS: From 2002 to 2010, 1256 breast cancer patients and 1416 healthy women were recruited. Anthropometric and reproductive factors were collected from medical charts. Breast cancer subtype was defined by ER, PR, and HER2 status. Polytomous logistic regression was used to evaluate associations between risk factors and breast cancer subtypes, with subgroup analysis by menopausal status...
April 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28118209/menstrual-and-reproductive-factors-in-the-risk-of-thyroid-cancer-in-japanese-women-the-japan-public-health-center-based-prospective-study
#16
Sangah Shin, Norie Sawada, Eiko Saito, Taiki Yamaji, Motoki Iwasaki, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
The aim of this study was to evaluate the associations between menstrual and reproductive factors and thyroid cancer risk among Japanese women. A total 54 776 women aged 40-69 years completed a self-administered questionnaire, which included menstrual and reproductive history. During 1990-2012, 187 newly diagnosed cases of thyroid cancer were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) for menstrual and reproductive factors and incidence of thyroid cancer were estimated using Cox proportional hazards regression...
January 21, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28086982/reproductive-factors-and-the-risk-of-triple-negative-breast-cancer-in-white-women-and-african-american-women-a-pooled-analysis
#17
Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Jill A McDonald, Michael S Simon, Suzanne G Folger, Jane Sullivan-Halley, Dennis M Deapen, Michael F Press, Leslie Bernstein
BACKGROUND: Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whether all of these are risk factors for triple-negative breast cancer (TNBC). METHODS: We evaluated the associations of these reproductive factors with TNBC, in 2658 patients with breast cancer (including 554 with TNBC) and 2448 controls aged 20-64 years, who participated in one of the three population-based case-control studies: the Women's Contraceptive and Reproductive Experiences Study, the Women's Breast Carcinoma in situ Study, or the Women's Learning the Influence of Family and Environment Study...
January 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27996108/effect-of-reproductive-history-and-exogenous-hormone-use-on-cognitive-function-in-mid-and-late-life
#18
Roksana Karim, Ha Dang, Victor W Henderson, Howard N Hodis, Jan St John, Roberta D Brinton, Wendy J Mack
OBJECTIVES: To investigate the association between reproductive history indicators of hormonal exposure, including reproductive period, pregnancy, and use of hormonal contraceptives, and mid- and late-life cognition in postmenopausal women. DESIGN: Analysis of baseline data from two randomized clinical trials: the Women's Isoflavone Soy Health and the Early vs Late Intervention Trial of Estradiol. SETTING: University academic research center...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27919437/fertile-lifespan-characteristics-and-all-cause-and-cause-specific-mortality-among-postmenopausal-women-the-rotterdam-study
#19
Loes Jaspers, Maryam Kavousi, Nicole S Erler, Albert Hofman, Joop S E Laven, Oscar H Franco
OBJECTIVE: To characterize the relation between established and previously unexplored characteristics of the fertile life with all-cause and cause-specific mortality. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 4,076 postmenopausal women. INTERVENTION(S): Women's fertile lifespan (age at menarche to menopause), number of children, maternal age at first and last child, maternal lifespan (interval between maternal age at first and last child), postmaternal fertile lifespan (interval between age at last child and menopause), lifetime cumulative number of menstrual cycles, and unopposed cumulative endogenous estrogen (E) exposure...
February 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27880720/the-impact-of-reproductive-life-on-breast-cancer-risk-in-women-with-family-history-or-brca-mutation
#20
Angela Toss, Giovanni Grandi, Angelo Cagnacci, Luigi Marcheselli, Silvia Pavesi, Elisabetta De Matteis, Elisabetta Razzaboni, Chiara Tomasello, Stefano Cascinu, Laura Cortesi
Reproductive history and exogenous hormonal exposures are acknowledged risk factors for breast cancer in the general population. In women at increased breast cancer risk for genetic predisposition or positive family history, data regarding these risk factors are limited or conflicting, and recommendations for these categories are unclear. We evaluated the characteristics of reproductive life in 2522 women at increased genetic or familial breast cancer risk attending our Family Cancer Center. Breast cancers in BRCA mutation carriers were more likely to be hormone receptor negative, diagnosed at 35 years or before and multiple during the lifetime than tumors in women at increased familial risk, while the distribution of invasive cancers and HER2 positive tumors was similar in the different risk groups...
February 7, 2017: Oncotarget
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