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Liver trasplant

Gabriele A Vassallo, Claudia Tarli, Maria M Rando, Carolina Mosoni, Antonio Mirijello, Adwoa Agyei-Nkansah, Mariangela Antonelli, Luisa Sestito, Germano Perotti, Daniela Di Giuda, Salvatore Agnes, Antonio Grieco, Antonio Gasbarrini, Giovanni Addolorato
Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis...
December 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
Mario Vilatobá, Miguel Ángel Mercado, Alan Gabriel Contreras-Saldivar, Rafael Paulino Leal-Villalpando, Jorge Zamudio-Bautista, Ignacio García-Juárez, Armando Gamboa-Domínguez
Orthotopic liver transplantation (OLT) is the treatment of choice for end stage liver disease. Many studies show an inverse relationship between the number of procedures and operative mortality. The objective of the study is to show the results of our center and determine if it can have comparable results to high volumen centers. This is a retrospective study which analyzed the information of patients with OLT at our institution from 1985 to December 31, 2012. Depending on date of transplantation, the study was divided into three stages...
2017: Gaceta Médica de México
Sanjay K Yadav, Sanjiv Saigal, Narendra S Choudhary, Sujit Saha, Navin Kumar, Arvinder S Soin
Cytomegalovirus (CMV) infection is the most common viral infection in liver transplant recipients, affecting post-transplant patients and graft survival. Recent advances in diagnosis and management of CMV have led to marked reduction in incidence, severity, and its associated morbidity and mortality. CMV DNA assay is the most commonly used laboratory parameter to diagnose and monitor CMV infection. Current evidence suggests that both pre-emptive and universal prophylaxis approaches are equally justified in liver transplant recipients...
June 2017: Journal of Clinical and Experimental Hepatology
M A Gentil, C González-Corvillo, M Perelló, S Zarraga, C Jiménez-Martín, L R Lauzurica, A Alonso, A Franco, D Hernández-Marrero, A Sánchez-Fructuoso
Hepatitis C (HC) is a very relevant negative prognosis factor for graft and transplant recipient survival. New direct-acting antivirals (DAAs) allow us to solve this problem in an effective way. It is crucial to understand their real impact in our daily practice. We analyzed treatment results with DAA, free of interferon, in kidney transplant recipients (KTRs) from 15 Spanish hospitals (Grupo Español de Actualización en Trasplante), regarding effectiveness, tolerance, and impact on immunosuppression, renal function-proteinuria, and diabetes...
November 2016: Transplantation Proceedings
Ramon Antônio Oliveira, Ruth Natália Teresa Turrini, Vanessa de Brito Poveda
OBJECTIVE: to investigate the evidence available in the literature on non-adherence to immunosuppressive therapy among patients undergoing liver transplantation. METHOD: integrative literature review, including research whose sample consisted of patients aged over 18 years undergoing liver transplantation. It excluded those containing patients undergoing multiple organ transplants. For the selection of articles, Medline / Pubmed, CINAHL, LILACS, Scopus and Embase were searched...
August 29, 2016: Revista Latino-americana de Enfermagem
Massimo Venturini, Claudio Sallemi, Caterina Colantoni, Giulia Agostini, Gianpaolo Balzano, Antonio Esposito, Antonio Secchi, Francesco De Cobelli, Massimo Falconi, Lorenzo Piemonti, Paola Maffi, Alessandro Del Maschio
OBJECTIVE: Islet allotransplantation is a less invasive alternative to surgical pancreas transplantation for Type 1 diabetes, while percutaneous intraportal islet autotransplantation (PIPIAT) is usually performed after pancreatic surgery to prevent diabetes. Our aim was to assess the feasibility, radiological aspects, complications and clinical outcome of PIPIAT following pancreatic surgery for not only chronic pancreatitis but also benign and malignant nodules. METHODS: From 2008 to 2012, 41 patients were enrolled for PIPIAT 12-48 h after pancreatic surgery (extended pancreatic surgery for chronic pancreatitis and benign/malignant neoplasms)...
August 2016: British Journal of Radiology
Alejandro Forner, María Reig, María Varela, Marta Burrel, Jaime Feliu, Javier Briceño, Javier Sastre, Luis Martí-Bonmati, Josep María Llovet, José Ignacio Bilbao, Bruno Sangro, Fernando Pardo, Carmen Ayuso, Concepció Bru, Josep Tabernero, Jordi Bruix
Hepatocellular carcinoma is the most common primary malignancy of the liver and one of the most frequent causes of death in patients with liver cirrhosis. Simultaneously with the recognition of the clinical relevance of this neoplasm, in recent years there have been important developments in the diagnosis, staging and treatment of HCC. Consequently, the Asociación Española para el Estudio del Hígado has driven the need to update clinical practice guidelines, continuing to invite all the societies involved in the diagnosis and treatment of this disease to participate in the drafting and approval of the document (Sociedad Española de Trasplante Hepático, Sociedad Española de Radiología Médica, Sociedad Española de Radiología Vascular e Intervencionista y Sociedad Española de Oncología Médica)...
June 3, 2016: Medicina Clínica
P Mellado, I Benítez, F Sánchez-Carrillo, A León, J M Álamo, M A Gómez
OBJECTIVE: To determine the management of haemostasis and transfusion practice in the field of liver transplantation in Spain. METHODS: A questionnaire was developed for physicians in anaesthesiology of all centres performing liver transplantation in Spain. The information required made reference to the 12 months prior to its distribution, from January 1 to December 31, 2011. RESULTS: Data were collected from 24 centres in which liver transplantation is performed in Spain...
February 2016: Revista Española de Anestesiología y Reanimación
Fernando Pardo, José Antonio Pons, Javier Briceño
With the aim to promote the elaboration of consensus documents on state of the art topics in liver transplantation with multidisciplinary management, the Spanish Society for Liver Transplantation (SETH) organized the V Consensus Meeting with the participation of experts from all the Spanish liver transplant programs. In this edition, the following topics were revised, and we present the summary: 1. High-risk receptors; 2. Immunosuppression scenarios; and 3. Management of the patient with hepatocarcinoma in the waiting list...
December 2015: Gastroenterología y Hepatología
Fernando Pardo, José Antonio Pons, Javier Briceño
With the aim to promote the elaboration of consensus documents on state of the art topics in liver transplantation with multidisciplinary management, the Spanish Society for Liver Transplantation (SETH) organized the V Consensus Meeting with the participation of experts from all the Spanish liver transplant programs. In this edition, the following topics were revised, and we present the summary: 1. High-risk receptors; 2. Immunosuppression scenarios; and 3. Management of the patient with hepatocarcinoma in the waiting list...
December 2015: Cirugía Española
Mizuki Ninomiya, Ken Shirabe, Marcelo E Facciuto, Myron E Schwartz, Sander S Florman, Tomoharu Yoshizumi, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Yoshihiko Maehara
BACKGROUND: Living donor liver transplantation (LDLT) is an important treatment option for unresectable hepatocellular carcinoma (HCC), but whether recurrence and survival in LDLT differ from those in deceased donor liver transplantation (DDLT) remains controversial. STUDY DESIGN: A retrospective analysis was performed between patients with HCC who underwent LDLT in a Japanese institute (n = 133) and those who underwent DDLT in a United States institute (n = 362)...
March 2015: Journal of the American College of Surgeons
Valentín Cuervas-Mons, Gloria de la Rosa, Fernando Pardo, Fernando San Juan, Andrés Valdivieso
BACKGROUND AND OBJECTIVE: Liver transplantation (LT) is a proven effective treatment of severe liver disease. The aim of this paper is to analyze the results of LT in Spain during the period 1984-2012. PATIENTS AND METHOD: We analyze the results of the database of Spanish Liver Transplant Registry. RESULTS: A total of 20,288 transplants were performed in 18,568 patients. The median age of the donor and recipient increased during the analysis period: 25 years (95% confidence interval [95% CI] 18-40) and 47 years (95% CI 34-55), respectively, in the period 1984-1994 compared to 59 years (95% CI 33-65; P<...
April 20, 2015: Medicina Clínica
Carlos Vallejo, Montserrat Batlle, Lourdes Vázquez, Carlos Solano, Antonia Sampol, Rafael Duarte, Dolores Hernández, Javier López, Montserrat Rovira, Santiago Jiménez, David Valcárcel, Vicente Belloch, Mónica Jiménez, Isidro Jarque
This is the first prospective study of deferasirox in adult allogeneic hematopoietic stem cell transplant recipients with transfusional iron overload in hematologic malignancies. Patients at least six months post transplant were treated with deferasirox at a starting dose of 10 mg/kg/day for 52 weeks or until serum ferritin was less than 400 ng/mL on two consecutive occasions. Thirty patients were enrolled and 22 completed the study. A significant reduction from baseline in median serum ferritin and in liver iron concentration at 52 weeks was observed in the overall population: from 1440 to 755...
October 2014: Haematologica
Manuel Abradelo, Constantino Fondevila
The disbalance between the number of candidates to liver transplant and the number of liver grafts leads to waiting list mortality. Two potential ways of increasing the number of liver grafts are split liver transplantation and the transplantation of grafts from non-heart beating donors. Both of them were discussed in a consensus meeting of the Spanish Society of Liver Transplantation in October 2012. This paper outlines the conclusions of that meeting.
March 2014: Cirugía Española
Laura Lladó, Javier Bustamante
No abstract text is available yet for this article.
February 2014: Gastroenterología y Hepatología
Emilio Ramos Rubio, Jorge Ortiz de Urbina, Julio Santoyo Santoyo, Evaristo Varo Pérez
No abstract text is available yet for this article.
November 2, 2013: Medicina Clínica
Josep M Campistol, Valentín Cuervas-Mons, Nicolás Manito, Luis Almenar, Manuel Arias, Fernando Casafont, Domingo Del Castillo, María G Crespo-Leiro, Juan F Delgado, J Ignacio Herrero, Paloma Jara, José M Morales, Mercedes Navarro, Federico Oppenheimer, Martín Prieto, Luis A Pulpón, Antoni Rimola, Antonio Román, Daniel Serón, Piedad Ussetti
Solid-organ transplant recipients are at increased risk of developing cancer compared with the general population. Tumours can arise de novo, as a recurrence of a preexisting malignancy, or from the donated organ. The ATOS (Aula sobre Trasplantes de Órganos Sólidos; the Solid-Organ Transplantation Working Group) group, integrated by Spanish transplant experts, meets annually to discuss current advances in the field. In 2011, the 11th edition covered a range of new topics on cancer and transplantation. In this review we have highlighted the new concepts and best practices for managing cancer in the pre-transplant and post-transplant settings that were presented at the ATOS meeting...
October 2012: Transplantation Reviews
M A Varona, A Soriano, A Aguirre-Jaime, M A Barrera, M L Medina, N Bañon, S Mendez, E Lopez, J Portero, D Dominguez, A Gonzalez
Liver transplantation, the best option for many end-stage liver diseases, is indicated in more candidates than the donor availability. In this situation, this demanding treatment must achieve excellence, accessibility and patient satisfaction to be ethical, scientific, and efficient. The current consensus of quality measurements promoted by the Sociedad Española de Trasplante Hepático (SETH) seeks to depict criteria, indicators, and standards for liver transplantation in Spain. According to this recommendation, the Canary Islands liver program has studied its experience...
July 2012: Transplantation Proceedings
Yukio Ando
Familial amyloidotic polyneuropathy (FAP) is a hereditary intractable disease induced by mutated transthyretin (TTR). Since TTR is predominantly synthesized by liver, liver transplantation has been performed to halt the clinical symptoms of FAP in the worldwide. It has been well documented that liver transplantation could halt the progression of FAP manifestations. However, the surgery could not prevent ocular symptoms and in some cases, cardiopathy and neuroparthy progressed even after liver trasplantation...
November 2011: Rinshō Shinkeigaku, Clinical Neurology
Pablo Gámez, Vicente Díaz-Hellín, Carmen Marrón, Jose Carlos Meneses, Alicia de Pablo, Jose Luis Martín de Nicolás
The number of lung transplantations that are performed in Spain continues to grow, with 235 transplant recipients 2010. Non-heart-beating donations have contributed to this upward progression. Our Lung Transplant Unit began its activity in October 2008 and during these last three years 97% of the transplant interventions performed have been successful. In order to increase the number of donations, we have developed a non-heart-beating donor program as part of the existing organs program in our hospital. In doing so, the development of a multi-organic preservation method (lung, liver and kidney), which we call «Bithermia Preservation», was necessary...
September 2012: Archivos de Bronconeumología
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