keyword
MENU ▼
Read by QxMD icon Read
search

TRL

keyword
https://www.readbyqxmd.com/read/28218439/the-effects-of-exogenous-fatty-acids-and-niacin-on-human-monocyte-macrophage-plasticity
#1
Sergio Montserrat-de la Paz, Dolores Rodriguez, Magdalena P Cardelo, Maria C Naranjo, Beatriz Bermudez, Rocio Abia, Francisco J G Muriana, Sergio Lopez
SCOPE: Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages. METHODS AND RESULTS: We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28195668/towards-monodisperse-star-shaped-ladder-type-conjugated-systems-design-synthesis-stabilized-blue-electroluminescence-and-amplified-spontaneous-emission
#2
Wen-Yong Lai, Yi Jiang, Mei Fang, Si-Ju Chang, Jin-Jin Huang, Shuang-Quan Chu, Shan-Ming Hu, Cheng-Fang Liu, Wei Huang
A novel series of monodisperse star-shaped ladder-type oligo(p-phenylene)s, named as TrL-n (n = 1-3), have been explored. Their thermal and electrochemical properties, fluorescence transients, photoluminescence quantum yields, density functional theory calculations, electroluminescence (EL) and amplified spontaneous emission (ASE) properties have been systematically investigated to unravel the molecular design on optoelectronic properties. The resulting materials showed excellent structural perfection free of chemical defects, exhibiting great thermal stability (Td: 404-418°C and Tg:147-184°C) and amorphous glassy morphologies...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28183448/c-reactive-protein-levels-are-inversely-correlated-with-the-apolipoprotein-b-48-containing-triglyceride-rich-lipoprotein-production-rate-in-insulin-resistant-men
#3
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean-Charles Hogue, Myriam Leclerc, Marie-Ève Labonté, Johanne Marin, Benoît Lamarche, Patrick Couture
: The pro-inflammatory state and elevated plasma levels of post-prandial triglycerides (TG) are associated with increased cardiovascular disease risk. Recent studies suggested that the increase in the production rate of post-prandial lipoproteins observed in patients with insulin resistance (IR) may be caused, at least in part, by the dysregulation of intestinal insulin sensitivity triggered by inflammation. OBJECTIVE: The objective of the present study was to evaluate the association between IR, plasma C-reactive protein (CRP) levels and the kinetics of TG-rich lipoprotein (TRL) containing apolipoprotein (apo) B-48 in a large sample of insulin sensitive (IS) and IR men...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28058687/the-reasons-of-trithorax-like-expression-disturbance-in-trl-3609-allele-of-drosophila-melanogaster
#4
D A Karagodin, N V Battulina, T I Merkulova, E M Baricheva
The regulatory region of the Trl gene was analyzed using the mutation Trl (3609) , resulting from the insertion of the P-element into the promoter region of the gene as well as mutations obtained on its basis. It is shown that two last transcription start sites, which are most often used in vitro in S2 cells, are almost not used in vivo. Experimental data indicate that transcription terminators in transposons play an important role in the decrease in the transcription level of the recipient gene.
November 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27829633/a-label-free-time-resolved-luminescent-platform-for-sensitive-endonuclease-v-detection-based-on-exonuclease-iii-regulated-dna-tb-3-luminescence
#5
Huaijun Nie, Huifen Huang, Wang Li, Tao Yang
Endonuclease V (EndoV) plays the important role of nucleotide excision repair (NER) in the maintenance of genomic stability. Highly sensitive detection of EndoV was achieved through an oligonucleotides sensitizing Tb(3+) luminescent technique. We found that although both guanine-rich (G-rich) single-stranded DNA and dGMP could enhance the time-resolved luminescence of Tb(3+), their efficiencies of enhancement were considerably different. Employing such interesting phenomenon, a label-free and time-resolved luminescent strategy for the sensitive detection of EndoV activity was developed based on DNA-enhanced time-resolved luminescence (TRL) of Tb(3+)...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27798489/the-future-of-n-3-polyunsaturated-fatty-acid-therapy
#6
Michael H Davidson, Lane B Benes
PURPOSE OF REVIEW: This article focuses on the potential role by which a complex mixture of omega-3 fatty acids (OM3-FAs) may beneficially modify cardiovascular risk by modifying the cholesterol composition of atherogenic lipoproteins. This hypothesis is being tested in the STRENGTH trial, which is enrolling 13 000 patients on statins at high cardiovascular risk with hypertriglyceridemia and low HDL cholesterol (HDL-C) treated with an OM3-carboxylic acid. RECENT FINDINGS: Complex mixtures of OM3-FAs containing predominately eicosapentanoic acid and docosahexanoic acid in combination with statins lowers non-HDL by reducing triglyceride-rich lipoprotein cholesterol (TRL-C) while shifting small LDL cholesterol (LDL-C) to large LDL-C...
December 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27793802/a-sequence-upstream-of-canonical-pdz-binding-motif-within-cftr-cooh-terminus-enhances-nherf1-interaction
#7
Neeraj Sharma, Jessica LaRusch, Patrick R Sosnay, Laura B Gottschalk, Andrea P Lopez, Matthew J Pellicore, Taylor Evans, Emily Davis, Melis Atalar, Chan-Hyun Na, Gedge D Rosson, Deborah Belchis, Michal Milewski, Akhilesh Pandey, Garry R Cutting
The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1). In this study, we explored whether COOH-terminal sequences in CFTR beyond the PDZ-binding motif influence its interaction with NHERF1. NHERF1 displayed minimal self-association in blot overlays (NHERF1, Kd = 1,382 ± 61...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27741434/exogenous-fatty-acids-and-niacin-on-acute-prostaglandin-d2-production-in-human-myeloid-cells
#8
Sergio Montserrat-de la Paz, Beatriz Bermudez, Sergio Lopez, Maria C Naranjo, Yolanda Romero, Maria J Bando-Hidalgo, Rocio Abia, Francisco J G Muriana
Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pretreatment of M-CSF macrophages with autologous postprandial TRLs induced the down-regulation of HCA2 gene and up-regulation of genes encoding COX1 and COX2 enzymes in a fatty acid-dependent manner. These effects were paralleled by a higher PGD2 production with postprandial TRL-SFAs...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27613744/why-is-apolipoprotein-ciii-emerging-as-a-novel-therapeutic-target-to-reduce-the-burden-of-cardiovascular-disease
#9
REVIEW
Marja-Riitta Taskinen, Jan Borén
ApoC-III was discovered almost 50 years ago, but for many years, it did not attract much attention. However, as epidemiological and Mendelian randomization studies have associated apoC-III with low levels of triglycerides and decreased incidence of cardiovascular disease (CVD), it has emerged as a novel and potentially powerful therapeutic approach to managing dyslipidemia and CVD risk. The atherogenicity of apoC-III has been attributed to both direct lipoprotein lipase-mediated mechanisms and indirect mechanisms, such as promoting secretion of triglyceride-rich lipoproteins (TRLs), provoking proinflammatory responses in vascular cells and impairing LPL-independent hepatic clearance of TRL remnants...
October 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27593489/nanoparticle-based-b-cell-targeting-vaccines-tailoring-of-humoral-immune-responses-by-functionalization-with-different-tlr-ligands
#10
Claudia Zilker, Diana Kozlova, Viktoriya Sokolova, Huimin Yan, Matthias Epple, Klaus Überla, Vladimir Temchura
Induction of an appropriate type of humoral immune response during vaccination is essential for protection against viral and bacterial infections. We recently observed that biodegradable calcium phosphate (CaP) nanoparticles coated with proteins efficiently targeted and activated naïve antigen-specific B-cells in vitro. We now compared different administration routes for CaP-nanoparticles and demonstrated that intramuscular immunization with such CaP-nanoparticles induced stronger immune responses than immunization with monovalent antigen...
September 2, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27553856/remnant-lipoprotein-size-distribution-profiling-via-dynamic-light-scattering-analysis
#11
Richa Chandra, Birgit Mellis, Kyana Garza, Samee A Hameed, James M Jurica, Ana V Hernandez, Mia N Nguyen, Chandra K Mittal
BACKGROUND: Remnant lipoproteins (RLP) are a metabolically derived subpopulation of triglyceride-rich lipoproteins (TRL) in human blood that are involved in the metabolism of dietary fats or triglycerides. RLP, the smaller and denser variants of TRL particles, are strongly correlated with cardiovascular disease (CVD) and were listed as an emerging atherogenic risk factor by the AHA in 2001. METHODS: Varying analytical techniques used in clinical studies in the size determination of RLP contribute to conflicting hypotheses in regard to whether larger or smaller RLP particles contribute to CVD progression, though multiple pathways may exist...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27552088/metabolic-profile-and-pharmacokinetics-of-polyphyllin-i-an-anticancer-candidate-in-rats-by-uplc-qtof-ms-ms-and-lc-tq-ms-ms
#12
Yu-Cai Liu, He Zhu, Shailendra Shakya, Jun-Wen Wu
Polyphyllin I (PPI), a natural steroidal saponin originating from rihzome of Paris polyphylla, is a potential anticancer candidate. Previous pharmacokinetics study showed that the oral bioavailability of PPI was very low, which suggested that certain amount of PPI might be metabolized in vivo. However, to date, information regarding the final metabolic fates of PPI is very limited. In this study, metabolites of PPI and their pharmacokinetics in rats were investigated using UPLC-QTOF-MS/MS and LC-TQ-MS/MS. A total of seven putative metabolites, including six phase I and one phase II metabolites, were detected and identified with three exact structures by comparison with authentic standards for the first time...
August 23, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27539557/co-amorphous-formation-induced-by-combination-of-tranilast-and-diphenhydramine-hydrochloride
#13
Hiroshi Ueda, Kazunori Kadota, Masaaki Imono, Takuya Ito, Ayaka Kunita, Yuichi Tozuka
In this study, we investigated the formation of a co-amorphous system of tranilast (TRL) and diphenhydramine hydrochloride (DPH), which are drugs used for treating allergies and inflammation. The crystallization from undercooled melts of the drugs and drug mixtures was evaluated by thermal analysis. Both drugs in the amorphous state underwent crystallization on heating, although the mixture remained in the amorphous state, indicating the formation of a co-amorphous system. The physicochemical properties of co-amorphous TRL-DPH prepared by the melting-cooling process were studied...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27502717/tumor-related-leukocytosis-is-associated-with-poor-radiation-response-and-clinical-outcome-in-uterine-cervical-cancer-patients
#14
Y Cho, K H Kim, H I Yoon, G E Kim, Y B Kim
BACKGROUND: To evaluate response to radiation and clinical outcome of uterine cervical cancer patients with tumor-related leukocytosis (TRL) at initial diagnosis and during definitive radiotherapy. PATIENTS AND METHODS: We retrospectively analyzed 2456 patients with stage IA-IVA uterine cervical cancer who received definitive radiotherapy with (37.4%) or without (62.6%) platinum-based chemotherapy between 1986 and 2012. TRL was defined as two or more occurrences of leukocytosis over 9000/μl at the time of diagnosis and during the course of treatment...
August 8, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27496481/hypertension-in-pregnant-renal-and-liver-transplant-recipients
#15
A Madej, B Pietrzak, N Mazanowska, T Songin, B Kociszewska-Najman, A Cyganek, Z Jabiry-Zieniewicz, M Wielgos
BACKGROUND: Pregnancies in transplant recipients involve risks for both grafts and the fetus, and need to be carefully managed. Hypertension is the most frequent complications in pregnant transplant recipients, especially in renal transplant recipients. Strict control of blood pressure is essential for a favorable obstetric outcome and long-term graft survival. The aim of the study was to evaluate the influence of hypertension on obstetric outcome and graft function in pregnant renal transplant recipients (RTR) or liver transplant recipients (LTR) in comparison with healthy pregnant women...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27494809/modulating-luminescence-of-tb-3-with-biomolecules-for-sensing-heparin-and-its-contaminant-oscs
#16
Yihui Hu, Wenjing Guo, Yubin Ding, Hanjun Cheng, Hui Wei
The detection of heparin (Hep) and its contaminant oversulfated chondroitin sulfate (OSCS) is of great importance in clinics but remains challenging. Here, we report a sensitive and selective time-resolved luminescence (TRL) biosensing system for Hep by modulating the photoluminescence of Tb(3+) with guanine-rich ssDNA and Hep-specific AG73 peptide (RKRLQVQLSIRT). With the developed system, Hep including both unfractionated Hep (UFH) and the low molecular weight Hep (LMWH) has been successfully detected with a satisfactory detection limit...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27443326/targeting-apoc-iii-to-reduce-coronary-disease-risk
#17
REVIEW
Sumeet A Khetarpal, Arman Qamar, John S Millar, Daniel J Rader
Triglyceride-rich lipoproteins (TRLs) are causal contributors to the risk of developing coronary artery disease (CAD). Apolipoprotein C-III (apoC-III) is a component of TRLs that elevates plasma triglycerides (TGs) through delaying the lipolysis of TGs and the catabolism of TRL remnants. Recent human genetics approaches have shown that heterozygous loss-of-function mutations in APOC3, the gene encoding apoC-III, lower plasma TGs and protect from CAD. This observation has spawned new interest in therapeutic efforts to target apoC-III...
September 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27378472/triglyceride-rich-lipoprotein-metabolism-in-women-roles-of-apoc-ii-and-apoc-iii
#18
Esther M Ooi, Dick C Chan, Leanne Hodson, Martin Adiels, Jan Boren, Fredrik Karpe, Barbara A Fielding, Gerald F Watts, P Hugh R Barrett
BACKGROUND: Experimental data suggest that apolipoprotein (apo) C-II and C-III regulate triglyceride-rich lipoprotein (TRL) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRLs with apoC-II and apoC-III concentrations and kinetics in women. MATERIAL AND METHODS: The kinetics of plasma apoC-II, apoC-III and very low-density lipoprotein (VLDL) apoB-100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modelling in 60 women with wide-ranging body mass index (19·5-32·9 kg/m(2) )...
August 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27339288/acute-effects-of-dietary-fatty-acids-on-osteclastogenesis-via-rankl-rank-opg-system
#19
M Carmen Naranjo, Indara Garcia, Beatriz Bermudez, Sergio Lopez, Magdalena P Cardelo, Rocio Abia, Francisco J G Muriana, Sergio Montserrat-de la Paz
SCOPE: Postprandial state is directly linked with chronic diseases. We hypothesized that dietary fats may have acute effects on health status by modulating osteoclast differentiation and activation in a fatty acid-dependent manner. METHODS AND RESULTS: In healthy subjects, a fat-enriched meal increased plasma levels of the RANKL (receptor activator of nuclear factor κB ligand)/OPG (osteoprotegerin) ratio (SFAs > MUFAs = PUFAs) in the postprandial state. Postprandial TRL-SFAs enhanced tartrate-resistant acid phosphatase (TRAP) activity and the expression of osteoclast marker genes (TRAP, OSCAR, RANK, and CATHK) while downregulated the expression of OPG gene in human monocyte-derived osteoclasts...
June 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27289394/effects-of-salt-stress-on-eco-physiological-characteristics-in-robinia-pseudoacacia-based-on-salt-soil-rhizosphere
#20
Peili Mao, Yujuan Zhang, Banghua Cao, Longmei Guo, Hongbo Shao, Zhenyu Cao, Qiankun Jiang, Xuan Wang
Robinia pseudoacacia is the main arbor species in the coastal saline-alkali area of the Yellow River Delta. Because most studies focus on the aboveground parts, detailed information regarding root functioning under salinity is scare. Root traits of seedlings of R. pseudoacacia including morphological, physiological and growth properties under four salinity levels (CK, 1‰, 3‰ and 5‰ NaCl) were studied by the pot experiments to better understand their functions and relationships with the shoots. The results showed that seedling biomass decreased by the reduction of root, stem and leaf biomass with the increase of salinity levels...
October 15, 2016: Science of the Total Environment
keyword
keyword
85301
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"