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Sergio Montserrat-de la Paz, Beatriz Bermudez, Sergio Lopez, Maria C Naranjo, Yolanda Romero, Maria J Bando-Hidalgo, Rocio Abia, Francisco Jg Muriana
Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pretreatment of M-CSF macrophages with autologous postprandial TRLs induced the down-regulation of HCA2 gene and up-regulation of genes encoding COX1 and COX2 enzymes in a fatty acid-dependent manner. These effects were paralleled by a higher PGD2 production with postprandial TRL-SFAs...
September 28, 2016: Journal of Nutritional Biochemistry
Marja-Riitta Taskinen, Jan Borén
ApoC-III was discovered almost 50 years ago, but for many years, it did not attract much attention. However, as epidemiological and Mendelian randomization studies have associated apoC-III with low levels of triglycerides and decreased incidence of cardiovascular disease (CVD), it has emerged as a novel and potentially powerful therapeutic approach to managing dyslipidemia and CVD risk. The atherogenicity of apoC-III has been attributed to both direct lipoprotein lipase-mediated mechanisms and indirect mechanisms, such as promoting secretion of triglyceride-rich lipoproteins (TRLs), provoking proinflammatory responses in vascular cells and impairing LPL-independent hepatic clearance of TRL remnants...
October 2016: Current Atherosclerosis Reports
C Zilker, D Kozlova, V Sokolova, H Yan, M Epple, K Überla, V Temchura
Induction of an appropriate type of humoral immune response during vaccination is essential for protection against viral and bacterial infections. We recently observed that biodegradable calcium phosphate (CaP) nanoparticles coated with proteins efficiently targeted and activated naïve antigen-specific B-cells in vitro. We now compared different administration routes for CaP-nanoparticles and demonstrated that intramuscular immunization with such CaP-nanoparticles induced stronger immune responses than immunization with monovalent antigen...
September 1, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Richa Chandra, Birgit Mellis, Kyana Garza, Samee A Hameed, James M Jurica, Ana V Hernandez, Mia N Nguyen, Chandra K Mittal
BACKGROUND: Remnant lipoproteins (RLP) are a metabolically derived subpopulation of triglyceride-rich lipoproteins (TRL) in human blood that are involved in the metabolism of dietary fats or triglycerides. RLP, the smaller and denser variants of TRL particles, are strongly correlated with cardiovascular disease (CVD) and were listed as an emerging atherogenic risk factor by the AHA in 2001. METHODS: Varying analytical techniques used in clinical studies in the size determination of RLP contribute to conflicting hypotheses in regard to whether larger or smaller RLP particles contribute to CVD progression, though multiple pathways may exist...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Yu-Cai Liu, He Zhu, Shailendra Shakya, Jun-Wen Wu
Polyphyllin I (PPI), a natural steroidal saponin originated from rihzome of Paris polyphylla, is recognized as one of potential anticancer candidates. Previous pharmacokinetics study showed that the oral bioavailability of PPI was very low, which suggested that certain amount of PPI might be metabolized in vivo. However, up to date, information regarding the final metabolic fates of PPI was very limited. In this study, metabolites of PPI and their pharmacokinetics in rats were investigated using UPLC-QTOF-MS/MS and LC-TQ-MS/MS...
August 23, 2016: Biomedical Chromatography: BMC
Hiroshi Ueda, Kazunori Kadota, Masaaki Imono, Takuya Ito, Ayaka Kunita, Yuichi Tozuka
In this study, we investigated the formation of a co-amorphous system of tranilast (TRL) and diphenhydramine hydrochloride (DPH), which are drugs used for treating allergies and inflammation. The crystallization from undercooled melts of the drugs and drug mixtures was evaluated by thermal analysis. Both drugs in the amorphous state underwent crystallization on heating, although the mixture remained in the amorphous state, indicating the formation of a co-amorphous system. The physicochemical properties of co-amorphous TRL-DPH prepared by the melting-cooling process were studied...
August 15, 2016: Journal of Pharmaceutical Sciences
Y Cho, K H Kim, H I Yoon, G E Kim, Y B Kim
BACKGROUND: To evaluate response to radiation and clinical outcome of uterine cervical cancer patients with tumor-related leukocytosis (TRL) at initial diagnosis and during definitive radiotherapy. PATIENTS AND METHODS: We retrospectively analyzed 2456 patients with stage IA-IVA uterine cervical cancer who received definitive radiotherapy with (37.4%) or without (62.6%) platinum-based chemotherapy between 1986 and 2012. TRL was defined as two or more occurrences of leukocytosis over 9000/μl at the time of diagnosis and during the course of treatment...
August 8, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
A Madej, B Pietrzak, N Mazanowska, T Songin, B Kociszewska-Najman, A Cyganek, Z Jabiry-Zieniewicz, M Wielgos
BACKGROUND: Pregnancies in transplant recipients involve risks for both grafts and the fetus, and need to be carefully managed. Hypertension is the most frequent complications in pregnant transplant recipients, especially in renal transplant recipients. Strict control of blood pressure is essential for a favorable obstetric outcome and long-term graft survival. The aim of the study was to evaluate the influence of hypertension on obstetric outcome and graft function in pregnant renal transplant recipients (RTR) or liver transplant recipients (LTR) in comparison with healthy pregnant women...
June 2016: Transplantation Proceedings
Yihui Hu, Wenjing Guo, Yubin Ding, Hanjun Cheng, Hui Wei
The detection of heparin (Hep) and its contaminant oversulfated chondroitin sulfate (OSCS) is of great importance in clinics but remains challenging. Here, we report a sensitive and selective time-resolved luminescence (TRL) biosensing system for Hep by modulating the photoluminescence of Tb(3+) with guanine-rich ssDNA and Hep-specific AG73 peptide (RKRLQVQLSIRT). With the developed system, Hep including both unfractionated Hep (UFH) and the low molecular weight Hep (LMWH) has been successfully detected with a satisfactory detection limit...
December 15, 2016: Biosensors & Bioelectronics
Sumeet A Khetarpal, Arman Qamar, John S Millar, Daniel J Rader
Triglyceride-rich lipoproteins (TRLs) are causal contributors to the risk of developing coronary artery disease (CAD). Apolipoprotein C-III (apoC-III) is a component of TRLs that elevates plasma triglycerides (TGs) through delaying the lipolysis of TGs and the catabolism of TRL remnants. Recent human genetics approaches have shown that heterozygous loss-of-function mutations in APOC3, the gene encoding apoC-III, lower plasma TGs and protect from CAD. This observation has spawned new interest in therapeutic efforts to target apoC-III...
September 2016: Current Atherosclerosis Reports
Esther M Ooi, Dick C Chan, Leanne Hodson, Martin Adiels, Jan Boren, Fredrik Karpe, Barbara A Fielding, Gerald F Watts, P Hugh R Barrett
BACKGROUND: Experimental data suggest that apolipoprotein (apo) C-II and C-III regulate triglyceride-rich lipoprotein (TRL) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRLs with apoC-II and apoC-III concentrations and kinetics in women. MATERIAL AND METHODS: The kinetics of plasma apoC-II, apoC-III and very low-density lipoprotein (VLDL) apoB-100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modelling in 60 women with wide-ranging body mass index (19·5-32·9 kg/m(2) )...
August 2016: European Journal of Clinical Investigation
M Carmen Naranjo, Indara Garcia, Beatriz Bermudez, Sergio Lopez, Magdalena P Cardelo, Rocio Abia, Francisco Jg Muriana, Sergio Montserrat-de la Paz
SCOPE: Postprandial state is directly linked with chronic diseases. We hypothesized that dietary fats may have acute effects on health status by modulating osteoclast differentiation and activation in a fatty acid-dependent manner. METHODS AND RESULTS: In healthy subjects, a fat-enriched meal increased plasma levels of the RANKL/OPG ratio (SFAs > MUFAs = PUFAs) in the postprandial state. Postprandial TRL-SFAs enhanced TRAP activity and the expression of osteoclast marker genes (TRAP, OSCAR, RANK, and CATHK) while downregulated the expression of OPG gene in human monocyte-derived osteoclasts...
June 24, 2016: Molecular Nutrition & Food Research
Peili Mao, Yujuan Zhang, Banghua Cao, Longmei Guo, Hongbo Shao, Zhenyu Cao, Qiankun Jiang, Xuan Wang
Robinia pseudoacacia is the main arbor species in the coastal saline-alkali area of the Yellow River Delta. Because most studies focus on the aboveground parts, detailed information regarding root functioning under salinity is scare. Root traits of seedlings of R. pseudoacacia including morphological, physiological and growth properties under four salinity levels (CK, 1‰, 3‰ and 5‰ NaCl) were studied by the pot experiments to better understand their functions and relationships with the shoots. The results showed that seedling biomass decreased by the reduction of root, stem and leaf biomass with the increase of salinity levels...
October 15, 2016: Science of the Total Environment
Pan Yuan, Guang-Da Ding, Hong-Mei Cai, Ke-Mo Jin, Martin Roger Broadley, Fang-Sen Xu, Lei Shi
BACKGROUND AND AIMS: An important adaptation of plants to phosphorus (P) deficiency is to alter root system architecture (RSA) to increase P acquisition from the soil, but soil-based observations of RSA are technically challenging, especially in mature plants. The aim of this study was to investigate the root development and RSA of oilseed rape (Brassica napus L.) under low and high soil P conditions during an entire growth cycle. METHODS: A new large Brassica-rhizotron system (approx...
August 2016: Annals of Botany
Limin Xu, Mengqi Xie, Jianbin Huang, Yun Yan
In situ characterization of the structure of reversible coordination polymers remains a challenge because of their dynamic and concentration-responsive nature. It is especially difficult to determine these structures in their self-assemblies where their degree of polymerization responds to the local concentration. In this paper, we report on the structure of reversible lanthanide coordination polymers in electrostatic assemblies using time-resolved luminescence (TRL) measurement. The reversible coordinating system is composed of the bifunctional ligand 1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane (L2EO4) and europium ion Eu(3+)...
June 14, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Peter P Toth
Approximately 25% of US adults are estimated to have hypertriglyceridemia (triglyceride [TG] level ≥150 mg/dL [≥1.7 mmol/L]). Elevated TG levels are associated with increased cardiovascular disease (CVD) risk, and severe hypertriglyceridemia (TG levels ≥500 mg/dL [≥5.6 mmol/L]) is a well-established risk factor for acute pancreatitis. Plasma TG levels correspond to the sum of the TG content in TG-rich lipoproteins (TRLs; ie, very low-density lipoproteins plus chylomicrons) and their remnants. There remains some uncertainty regarding the direct causal role of TRLs in the progression of atherosclerosis and CVD, with cardiovascular outcome studies of TG-lowering agents, to date, having produced inconsistent results...
2016: Vascular Health and Risk Management
D Sinning, D M Leistner, U Landmesser
Disorders of lipid metabolism play a major role in the development and progression of coronary artery disease. Dyslipidemia therefore plays a central role in therapeutic approaches for prevention and treatment of cardiovascular events associated with coronary artery disease. Epidemiological studies have shown an association between various lipid metabolism parameters, the risk of developing coronary artery disease and progression of a pre-existing disease. In particular, increased levels of low-density lipoprotein cholesterol (LDL-C), reduced levels of HDL cholesterol (HDL-C), as well as high levels of triglycerides and increased lipoprotein(a) [Lp(a)] levels can be taken into account when assessing the risk stratification of patients for primary prevention of coronary artery disease...
June 2016: Herz
Diego Lucero, Graciela I López, Susana Gorzalczany, Mariano Duarte, Esteban González Ballerga, Juan Sordá, Laura Schreier, Valeria Zago
UNLABELLED: Our aim was to analyze the effect of circulating triglyceride rich lipoprotein (TRL) on endothelial function in metabolic syndrome (MetS). METHODS: We studied 40 patients with MetS (ATPIII), divided into those presenting normal endothelial function (n=19) and those with endothelial dysfunction (n=21) by means of the evaluation of pulse wave velocity, before and after brachial artery ischemia. In fasting serum we measured lipid and lipoprotein profile, insulin and glucose (HOMA-IR)...
August 2016: Clinical Biochemistry
Changting Xiao, Satya Dash, Cecilia Morgantini, Gary F Lewis
OBJECTIVE: Increased production of intestinal triglyceride-rich lipoproteins (TRLs) contributes to dyslipidemia and increased risk of atherosclerotic cardiovascular disease in insulin resistance and type 2 diabetes. We have previously demonstrated that enteral glucose enhances lipid-stimulated intestinal lipoprotein particle secretion. Here, we assessed whether glucose delivered systemically by intravenous infusion also enhances intestinal lipoprotein particle secretion in humans. APPROACH AND RESULTS: On 2 occasions, 4 to 6 weeks apart and in random order, 10 healthy men received a constant 15-hour intravenous infusion of either 20% glucose to induce hyperglycemia or normal saline as control...
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
N V Dorogova, A S Khrushcheva, E V Fedorova, A A Ogienko, E M Baricheva
The GAGA protein of drosophila is a factor involved in epigenetic transcription regulation of a large gene group controlling developmental processes. In this paper, the role of GAGA factor in germ cell migration is demonstrated as well as its effect on the gonad development in drosophila embryogenesis. Mutations in the Trl gene, encoding GAGA factor, prematurely induces the active migration program and relocation of the primordial cells inward the embryo before the beginning of gastrulation. The germ cells that prematurely separated from the main group migrate ectopically, lose orientation, and stay out of gonad development...
January 2016: Ontogenez
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