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https://www.readbyqxmd.com/read/29752277/the-highly-metastatic-nature-of-uterine-cervical-endometrial-cancer-displaying-tumor-related-leukocytosis-clinical-and-preclinical-investigations
#1
Tomoyuki Sasano, Seiji Mabuchi, Katsumi Kozasa, Hiromasa Kuroda, Mahiru Kawano, Ryoko Takahashi, Naoko Komura, Eriko Yokoi, Yuri Matsumoto, Kae Hashimoto, Kenjiro Sawada, Eiichi Morii, Tadashi Kimura
PURPOSE: The aim of this study was to investigate the metastatic potential of uterine cervical and endometrial cancer displaying tumor-related leukocytosis (TRL). EXPERIMENTAL DESIGN: Clinical data on uterine cervical (N=732) and endometrial cancer (N=900) were collected, and the metastatic potential of TRL-positive cancer was evaluated in univariate and multivariate analyses. Tumor and blood samples obtained from cervical cancer patients, cervical cancer cell lines, and a mouse model of cervical cancer were employed to examine the mechanisms underlying the highly metastatic nature of TRL-positive cancer, focusing on tumor-derived granulocyte-colony stimulating factor (G-CSF) and the myeloid-derived suppressor cells (MDSC)-mediated premetastatic niche...
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29719224/nanosims-analysis-of-intravascular-lipolysis-and-lipid-movement-across-capillaries-and-into-cardiomyocytes
#2
Cuiwen He, Thomas A Weston, Rachel S Jung, Patrick Heizer, Mikael Larsson, Xuchen Hu, Christopher M Allan, Peter Tontonoz, Karen Reue, Anne P Beigneux, Michael Ploug, Andrea Holme, Matthew Kilburn, Paul Guagliardo, David A Ford, Loren G Fong, Stephen G Young, Haibo Jiang
The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital tissues, but our understanding of TRL metabolism is limited, in part because TRL processing and lipid movement have never been visualized. To investigate the movement of TRL-derived lipids in the heart, mice were given an injection of [2 H]triglyceride-enriched TRLs, and the movement of 2 H-labeled lipids across capillaries and into cardiomyocytes was examined by NanoSIMS. TRL processing and lipid movement in tissues were extremely rapid...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29698057/differential-associations-between-plasma-concentrations-of-insulin-and-glucose-and-intestinal-expression-of-key-genes-involved-in-chylomicron-metabolism
#3
Jean-Philippe Drouin-Chartier, Andre J Tremblay, Valéry Lemelin, Benoit Lamarche, Patrick Couture
The mechanisms underlying the oversecretion of apolipoprotein (apo) B-48-containing triglyceride-rich lipoproteins (TRL) in insulin-resistance (IR) states in humans remain to be fully understood. The objective of this study was to evaluate the association between the plasma levels of insulin and glucose and the intestinal expression of key genes involved in chylomicron metabolism in a large sample of nondiabetic men displaying various degrees of IR. Duodenal biopsies were obtained by gastroduodenoscopy in 127 men free of intestinal disease...
April 26, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29695248/use-of-the-self-organising-map-network-somnet-as-a-decision-support-system-for-regional-mental-health-planning
#4
Younjin Chung, Luis Salvador-Carulla, José A Salinas-Pérez, Jose J Uriarte-Uriarte, Alvaro Iruin-Sanz, Carlos R García-Alonso
BACKGROUND: Decision-making in mental health systems should be supported by the evidence-informed knowledge transfer of data. Since mental health systems are inherently complex, involving interactions between its structures, processes and outcomes, decision support systems (DSS) need to be developed using advanced computational methods and visual tools to allow full system analysis, whilst incorporating domain experts in the analysis process. In this study, we use a DSS model developed for interactive data mining and domain expert collaboration in the analysis of complex mental health systems to improve system knowledge and evidence-informed policy planning...
April 25, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29678154/genomic-regions-responsible-for-seminal-and-crown-root-lengths-identified-by-2d-3d-root-system-image-analysis
#5
Yusaku Uga, Ithipong Assaranurak, Yuka Kitomi, Brandon G Larson, Eric J Craft, Jon E Shaff, Susan R McCouch, Leon V Kochian
BACKGROUND: Genetic improvement of root system architecture is a promising approach for improved uptake of water and mineral nutrients distributed unevenly in the soil. To identify genomic regions associated with the length of different root types in rice, we quantified root system architecture in a set of 26 chromosome segment substitution lines derived from a cross between lowland indica rice, IR64, and upland tropical japonica rice, Kinandang Patong, (IK-CSSLs), using 2D & 3D root phenotyping platforms...
April 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29665987/beyond-ldl-what-role-for-pcsk9-in-triglyceride-rich-lipoprotein-metabolism
#6
REVIEW
Wieneke Dijk, Cédric Le May, Bertrand Cariou
Elevated plasma triglyceride (TG) levels are an independent risk factor for cardiovascular disease (CVD). Proprotein convertase subtilisin-kexin 9 (PCSK9) - a protein therapeutically targeted to lower plasma cholesterol levels - might regulate plasma TG-rich lipoprotein (TRL) levels. We provide a timely and critical review of the current evidence for a role of PCSK9 in TRL metabolism by assessing the impact of PCSK9 gene variants, by reviewing recent clinical data with PCSK9 inhibitors, and by describing the potential mechanisms by which PCSK9 might regulate TRL metabolism...
April 14, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29627378/brown-adipose-tissue-derived-angptl4-controls-glucose-and-lipid-metabolism-and-regulates-thermogenesis
#7
Abhishek K Singh, Binod Aryal, Balkrishna Chaube, Noemi Rotllan, Luis Varela, Tamas L Horvath, Yajaira Suárez, Carlos Fernández-Hernando
OBJECTIVES: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA), which are burned to generate heat. LPL activity is regulated by angiopoietin-like 4 (ANGPTL4), a secretory protein produced in adipose tissues (AT), liver, kidney, and muscle. While the role of ANGPTL4 in regulating lipoprotein metabolism is well established, the specific contribution of BAT derived ANGPTL4 in controlling lipid and glucose homeostasis is not well understood...
March 29, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29621263/wide-scan-imaging-with-swept-source-optical-coherent-tomography-for-glaucoma-diagnosis
#8
Eun Hee Hong, Yong Un Shin, Min Ho Kang, Heeyoon Cho, Mincheol Seong
PURPOSE: To determine glaucoma-discriminating abilities of macular and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements of wide scan (12X9mm) using swept-source optical coherence tomography (SS-OCT) compared to measurements of standard macula and disc scans (6 X 6 mm). METHODS: This retrospective chart review study included 60 glaucomatous and 62 healthy eyes of total 122 subjects who visited a glaucoma clinic and were examined with wide, standard macula, and standard disc scans of SS-OCT (DRI-OCT-1 Atlantis; Topcon Inc...
2018: PloS One
https://www.readbyqxmd.com/read/29618599/triglyceride-rich-lipoprotein-cholesterol-and-risk-of-cardiovascular-events-among-patients-receiving-statin-therapy-in-the-treating-to-new-targets-tnt-trial
#9
Antonio J Vallejo-Vaz, Rana Fayyad, S Matthijs Boekholdt, G Kees Hovingh, John J Kastelein, Shari Melamed, Philip Barter, David D Waters, Kausik K Ray
Background -Mendelian randomization data suggest genetic determinants of lifetime higher triglyceride-rich lipoprotein-cholesterol (TRL-C) are causally related to cardiovascular disease and therefore a potential therapeutic target. The relevance of TRL-C among patients receiving statins is unknown. We assessed the relationship between TRL-C and cardiovascular risk, and whether this risk was modifiable among patients receiving statins in the TNT trial. Methods -Patients with coronary heart disease [CHD] and LDL-C 130-250mg/dL entered an 8-week run-in phase with atorvastatin 10mg/day (ATV10)...
April 4, 2018: Circulation
https://www.readbyqxmd.com/read/29576536/%C3%AE-secretase-inhibition-lowers-plasma-triglyceride-rich-lipoproteins-by-stabilizing-the-ldl-receptor
#10
KyeongJin Kim, Ira J Goldberg, Mark J Graham, Meenakshi Sundaram, Enrico Bertaggia, Samuel X Lee, Li Qiang, Rebecca A Haeusler, Daniel Metzger, Pierre Chambon, Zemin Yao, Henry N Ginsberg, Utpal B Pajvani
Excess plasma triglycerides (TGs) are a key component of obesity-induced metabolic syndrome. We have shown that γ-secretase inhibitor (GSI) treatment improves glucose tolerance due to inhibition of hepatic Notch signaling but found additional Notch-independent reduction of plasma TG-rich lipoproteins (TRLs) in GSI-treated, as well as hepatocyte-specific, γ-secretase knockout (L-Ncst) mice, which suggested a primary effect on hepatocyte TRL uptake. Indeed, we found increased VLDL and LDL particle uptake in L-Ncst hepatocytes and Ncst-deficient hepatoma cells, in part through reduced γ-secretase-mediated low-density lipoprotein receptor (LDLR) cleavage and degradation...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29547399/apolipoprotein-c-iii-in-triglyceride-rich-lipoprotein-metabolism
#11
Bastian Ramms, Philip L S M Gordts
PURPOSE OF REVIEW: Apolipoprotein (apo) C-III is a key player in triglyceride-rich lipoprotein metabolism and strongly associated with elevated plasma triglyceride levels. Several new studies added important insights on apoC-III and its physiological function confirming its promise as a valid therapeutic target. RECENT FINDINGS: APOC3 is expressed in liver and intestine and regulates triglyceride-rich lipoprotein (TRL) catabolism and anabolism. The transcriptional regulation in both organs requires different regulatory elements...
June 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29546830/the-role-of-modified-lipoproteins-in-vascular-function-a-duet-between-monocytes-and-the-endothelium
#12
Johan G Schnitzler, Geesje M Dallinga-Thie, Jeffrey Kroon
Over the last century, many studies have demonstrated that low-density lipoprotein (LDL) is a key risk factor of cardiovascular diseases (CVD) related to atherosclerosis. Thus, for these CVD patients, LDL lowering agents are commonly used in the clinic to reduce the risk for CVD. LDL, upon modification, will develop distinct inflammatory and pro-atherogenic potential, leading to impaired endothelial behavior and subsequent increased foam cell formation. LDL can also directly affect circulating monocyte composition, rendering them in a more favorable position to migrate and accumulate in the subendothelial space...
March 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29544086/new-medications-targeting-triglyceride-rich-lipoproteins-can-inhibition-of-angptl3-or-apoc-iii-reduce-the-residual-cardiovascular-risk
#13
REVIEW
Vesa M Olkkonen, Juha Sinisalo, Matti Jauhiainen
Remarkably good results have been achieved in the treatment of atherosclerotic cardiovascular diseases (CVD) by using statin, ezetimibe, antihypertensive, antithrombotic, and PCSK9 inhibitor therapies and their proper combinations. However, despite this success, the remaining CVD risk is still high. To target this residual risk and to treat patients who are statin-intolerant or have an exceptionally high CVD risk for instance due to familial hypercholesterolemia (FH), new therapies are intensively sought. One pathway of drug development is targeting the circulating triglyceride-rich lipoproteins (TRL) and their lipolytic remnants, which, according to the current view, confer a major CVD risk...
March 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29537647/differential-effects-of-estrogen-and-progestin-on-apolipoprotein-b100-and-b48-kinetics-in-postmenopausal-women
#14
Stefania Lamon-Fava, Margaret R Diffenderfer, P Hugh R Barrett, Wing Yee Wan, Borbala Postfai, Chorthip Nartsupha, Gregory G Dolnikowski, Ernst J Schaefer
The distinct effects of the estrogen and progestin components of hormonal therapy on the metabolism of apolipoprotein (apo) B-containing lipoproteins have not been studied. We enrolled eight healthy postmenopausal women in a placebo-controlled, randomized, double-blind crossover study. Each subject received placebo, conjugated equine estrogen (CEE, 0.625 mg/day) and CEE plus medroxyprogesterone acetate (MPA, 2.5 mg/day) for 8 weeks in a randomized order, with a 4-week washout between phases. Main outcomes were the fractional catabolic rate (FCR) and production rate (PR) of apo B100 in triglyceride-rich lipoproteins (TRL), intermediate-density lipoproteins (IDL) and low -density lipoprotein (LDL) and of apo B48 in TRL...
February 2018: Lipids
https://www.readbyqxmd.com/read/29454173/photo-assisted-electrochemical-abatement-of-trifluralin-using-a-cathode-containing-a-c-60-carbon-nanotubes-composite
#15
Aliyeh Hasanzadeh, Alireza Khataee, Mahmoud Zarei, Sang Woo Joo
This work reports the potential application of modified gas-diffusion electrode (GDE) with C60 -CNT composite, as a stable and efficient cathode material for degradation of trifluralin (TRL) pesticide by photo-assisted electrochemical (PE) process. C60 -CNT composite was prepared and characterized. Subsequently, a novel C60 -CNT composite modified GDE cathode was developed and the electrochemical and physical characteristics of the modified GDEs were studied. C60 -CNT composite/GDE showed great efficiencies for electro-generating H2 O2 , owing to huge surface area and high conductivity...
May 2018: Chemosphere
https://www.readbyqxmd.com/read/29449313/impaired-thermogenesis-and-sharp-increases-in-plasma-triglyceride-levels-in-gpihbp1-deficient-mice-during-cold-exposure
#16
Mikael Larsson, Christopher M Allan, Patrick J Heizer, Yiping Tu, Norma P Sandoval, Rachel S Jung, Rosemary L Walzem, Anne P Beigneux, Stephen G Young, Loren G Fong
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1 -/- mice, LPL remains stranded in the subendothelial spaces, causing hypertriglyceridemia, but how Gpihbp1 -/- mice respond to metabolic stress (e.g., cold exposure) has never been studied. In wild-type mice, cold exposure increases LPL-mediated processing of triglyceride-rich lipoproteins (TRLs) in brown adipose tissue (BAT), providing fuel for thermogenesis and leading to lower plasma triglyceride levels...
April 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29432213/regulation-of-intestinal-lipid-and-lipoprotein-metabolism-by-the-proglucagon-derived-peptides-glucagon-like-peptide-1-and-glucagon-like-peptide-2
#17
Erin E Mulvihill
PURPOSE OF REVIEW: The intestine is highly efficient at absorbing and packaging dietary lipids onto the structural protein apoB48 for distribution throughout the body. Here, we summarize recent advances into understanding the physiological and pharmacological actions of the proglucagon-derived peptides: glucagon like peptide 1 (GLP-1) and glucagon like peptide 2 (GLP-2) on intestinal lipoprotein secretion. RECENT FINDINGS: Several recent studies have elucidated mechanisms underlying the paradoxical effects of GLP-1 and GLP-2 on intestinal production of triglyceride-rich lipoproteins (TRLs)...
April 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29394647/-severe-therapy-related-pancytopenia-caused-by-uft-and-lv-in-a-patient-with-ascending-colon-cancer
#18
Takahiro Akiyama, Jun Yasutomi, Kimihiko Kusashio, Masanari Matsumoto, Takeshi Suzuki, Ayako Iida, Namiko Imamura, Arihito Yoshizumi, Rina Harano, Ikuo Udagawa, Masayuki Ohtsuka
We report a case of a 79-year-old man who developed severe therapy-related pancytopenia from tegafur uracil(UFT)and Leucovorin(LV)as adjuvant chemotherapy for ascending colon cancer. Laparoscopic right hemicolectomy resection was performed for the ascending colon cancer. Pathohistological analysis revealed that the ascending colon tumor was moderately differentiated tubular adenocarcinoma(T3, N1, M0, and Stage III a). Postoperative adjuvant chemotherapy with UFT and LV was administered. After 2 courses of chemotherapies, severe thrombocytopenia(Grade 4)and neutropenia(Grade 4)were noted...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29381796/substitution-of-dietary-%C3%AF-6-polyunsaturated-fatty-acids-for-saturated-fatty-acids-decreases-ldl-apolipoprotein-b-100-production-rate-in-men-with-dyslipidemia-associated-with-insulin-resistance-a-randomized-controlled-trial
#19
Jean-Philippe Drouin-Chartier, André J Tremblay, Marie-Claude Lépine, Valéry Lemelin, Benoît Lamarche, Patrick Couture
Background: The substitution of omega (ω)-6 (n-6) polyunsaturated fatty acids (PUFAs) for saturated fatty acids (SFAs) is advocated in cardiovascular disease prevention. The impact of this substitution on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains unknown. Objective: In men with dyslipidemia and IR, we evaluated the impact of substituting ω-6 PUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo) B-containing lipoproteins and on the intestinal expression of key genes involved in lipoprotein metabolism...
January 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29342252/triglyceride-rich-lipoprotein-cholesterol-trl-c-the-ugly-stepsister-of-ldl-c
#20
Michael H Davidson
No abstract text is available yet for this article.
February 14, 2018: European Heart Journal
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