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https://www.readbyqxmd.com/read/28929498/dog-skin-parasite-load-tlr-2-il-10-and-tnf-%C3%AE-expression-and-infectiousness
#1
Dandara Camila Morais Pereira-Fonseca, Fernanda Muller de Oliveira-Rovai, Lílian Aparecida Colebrusco Rodas, Carolina Aparecida Carlin Beloti, Rafaela Beatriz Pintor Torrecilha, Píer Kenji Rauschkolb Katsuda Ito, Saulo Vinícius Avanço, Rafael Silva Cipriano, Yuri Tani Utsunomiya, Roberto Mitsuyoshi Hiramoto, Leontides Calvo-Bado, Orin Courtenay, Gisele Fabrino Machado, Valéria Marçal Felix de Lima, Cáris Maroni Nunes
Visceral leishmaniosis is a zoonotic disease that is transmitted by Lutzomyia longipalpis sandflies. Dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. Type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α). In contrast, Type 2 immunity is predominantly humoral, associated with progression of the disease, and mediated by anti-inflammatory cytokines such as interleukin 10 (IL-10)...
September 20, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28893538/indispensable-role-of-lipoprotein-bound-apoe-in-adipogenesis-and-endocytosis-induced-by-postprandial-trl
#2
Mingyu Zhang, Yanhong Li, Xuehong Wei, Feng Tian, Fan Ouyang, Shuiping Zhao, Ling Liu
Diet-associated obesity is coexisted with postprandial hypertriglyceridemia that indicates increased number of triglyceride-rich lipoproteins (TRL). This study aimed to investigate the effect of postprandial TRL-bound apolipoprotein E (ApoE) on adipogenesis and potential mechanisms. 3T3-L1 cells were cultured with (i) human TRL (h-TRL) with or without insulin, or (ii) TRL from wild type mice (WT-TRL) or ApoE knock-out mice (EKO-TRL) and insulin. The differentiating adipocytes were incubated with different kinds of TRL labeled by red fluorescence and confocal microscopy was performed...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28825717/a-human-apoc3-missense-variant-and-monoclonal-antibody-accelerate-apoc-iii-clearance-and-lower-triglyceride-rich-lipoprotein-levels
#3
Sumeet A Khetarpal, Xuemei Zeng, John S Millar, Cecilia Vitali, Amritha Varshini Hanasoge Somasundara, Paolo Zanoni, James A Landro, Nicole Barucci, William J Zavadoski, Zhiyuan Sun, Hans de Haard, Ildikó V Toth, Gina M Peloso, Pradeep Natarajan, Marina Cuchel, Sissel Lund-Katz, Michael C Phillips, Alan R Tall, Sekar Kathiresan, Paul DaSilva-Jardine, Nathan A Yates, Daniel J Rader
Recent large-scale genetic sequencing efforts have identified rare coding variants in genes in the triglyceride-rich lipoprotein (TRL) clearance pathway that are protective against coronary heart disease (CHD), independently of LDL cholesterol (LDL-C) levels. Insight into the mechanisms of protection of these variants may facilitate the development of new therapies for lowering TRL levels. The gene APOC3 encodes apoC-III, a critical inhibitor of triglyceride (TG) lipolysis and remnant TRL clearance. Here we report a detailed interrogation of the mechanism of TRL lowering by the APOC3 Ala43Thr (A43T) variant, the only missense (rather than protein-truncating) variant in APOC3 reported to be TG lowering and protective against CHD...
September 2017: Nature Medicine
https://www.readbyqxmd.com/read/28801256/new-innovative-ecosystems-in-france-to-develop-the-bioeconomy
#4
REVIEW
Thierry Stadler, Jean-Marie Chauvet
The cluster's policy initiated in France in 2005 was a formidable opportunity to boost innovation in the bioeconomy and to develop innovation platforms allowing industrial demonstration and feasibility at technology readiness level (TRL) from 5 to 9. The IAR Cluster (Industries and Agro-Resources), based in the Hauts-de-France and Grand Est regions is completely dedicated to the bioeconomy. IAR's work has contributed to build a complete innovation ecosystem on bioeconomy by opening up relationships between actors along the full value chain...
August 8, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28751575/effects-of-intranasal-insulin-on-triglyceride-rich-lipoprotein-particle-production-in-healthy-men
#5
RANDOMIZED CONTROLLED TRIAL
Changting Xiao, Satya Dash, Priska Stahel, Gary F Lewis
OBJECTIVE: Insulin administered directly into the brain acutely suppresses hepatic glucose production and triglyceride-rich lipoprotein (TRL) secretion in rodents. In addition, intranasally administered insulin, which selectively raises cerebrospinal fluid insulin concentration, suppresses hepatic glucose production in humans; however, its effect on TRL secretion in humans has not previously been examined. In this study, we examined whether intranasal insulin, administered at a dose that has previously been shown to suppress hepatic glucose production, modulates TRL particle secretion by the liver and intestine in humans...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28719051/the-binding-mechanism-between-azoles-and-fgcyp51b-sterol-14%C3%AE-demethylase-of-fusarium-graminearum
#6
Hengwei Qian, Meilin Duan, Xiaomei Sun, Mengyu Chi, Ying Zhao, Wenxing Liang, Juan Du, Jinguang Huang, Baodu Li
BACKGROUND: Fusarium graminearum is the main pathogen of Fusarium Head Blight (FHB), a worldwide plant disease and one of the major wheat diseases in China. The control of the FHB is mainly dependent on the application of DMIs fungicides. Fungal sterol 14α-demethylase enzymes (CYP51) are the main target for DMIs fungicides. In order to investigate the binding mechanism between azoles and CYP51B in F.graminearum, the molecular modeling study and biological evaluation were performed. RESULTS: Firstly, the homology model based on the crystal structure of Aspergillus fumigatus was built...
July 18, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28676122/genome-wide-search-for-zelda-like-chromatin-signatures-identifies-gaf-as-a-pioneer-factor-in-early-fly-development
#7
Arbel Moshe, Tommy Kaplan
BACKGROUND: The protein Zelda was shown to play a key role in early Drosophila development, binding thousands of promoters and enhancers prior to maternal-to-zygotic transition (MZT), and marking them for transcriptional activation. Recently, we showed that Zelda acts through specific chromatin patterns of histone modifications to mark developmental enhancers and active promoters. Intriguingly, some Zelda sites still maintain these chromatin patterns in Drosophila embryos lacking maternal Zelda protein...
July 4, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28662934/high-triglycerides-and-low-high-density-lipoprotein-cholesterol-lipid-profile-in-rheumatoid-arthritis-a-potential-link-among-inflammation-oxidative-status-and-dysfunctional-high-density-lipoprotein
#8
Javier Rodríguez-Carrio, Mercedes Alperi-López, Patricia López, Raquel López-Mejías, Sara Alonso-Castro, Francisco Abal, Francisco J Ballina-García, Miguel Á González-Gay, Ana Suárez
BACKGROUND: The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. OBJECTIVES: Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TG(high)HDL(low)) in RA...
June 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502507/impact-of-bariatric-surgery-on-apolipoprotein-c-iii-levels-and-lipoprotein-distribution-in-obese-human-subjects
#9
Marie Maraninchi, Nadège Padilla, Sophie Béliard, Bruno Berthet, Juan-Patricio Nogueira, Jeanine Dupont-Roussel, Julien Mancini, Audrey Bégu-Le Corroller, Noémie Dubois, Rachel Grangeot, Catherine Mattei, Marion Monclar, Anastasia Calabrese, Carole Guérin, Charles Desmarchelier, Alain Nicolay, Changting Xiao, Patrick Borel, Gary F Lewis, René Valéro
BACKGROUND: Elevated apolipoprotein C-III (apoC-III) has been postulated to contribute to the atherogenic dyslipidemia seen in obesity and insulin-resistant states, mainly by impairing plasma triglyceride-rich lipoprotein (TRL) metabolism. Bariatric surgery is associated with improvements of several obesity-associated metabolic abnormalities, including a reduction in plasma triglycerides (TGs) and an increase in plasma high-density lipoprotein cholesterol (HDL-C). OBJECTIVES: We investigated the specific effect of bariatric surgery on apoC-III concentrations in plasma, non-HDL, and HDL fractions in relation to lipid profile parameters evolution...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28486852/the-relationship-between-migraine-and-lipid-sub-fractions-among-individuals-without-cardiovascular-disease-a-cross-sectional-evaluation-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#10
Alessandra C Goulart, Paulo A Lotufo, Itamar S Santos, Márcio S Bittencourt, Raul D Santos, Michael J Blaha, Steven Jones, Peter P Toth, Krishnaji Kulkarni, Isabela M Benseñor
Introduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] were determined by vertical auto profile (VAP)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28392500/metabolism-and-proteomics-of-large-and-small-dense-ldl-in-combined-hyperlipidemia-effects-of-rosuvastatin
#11
Nuntakorn Thongtang, Margaret R Diffenderfer, Esther M M Ooi, P Hugh R Barrett, Scott M Turner, Ngoc-Anh Le, W Virgil Brown, Ernst J Schaefer
Small dense LDL (sdLDL) has been reported to be more atherogenic than large buoyant LDL (lbLDL). We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin 40 mg/day. ApoB-100 kinetics in triglyceride-rich lipoproteins (TRLs), lbLDL (density [d] = 1.019-1.044 g/ml), and sdLDL (d = 1.044-1.063 g/ml) were determined in the fed state by using stable isotope tracers, mass spectrometry, and compartmental modeling. Compared with placebo, rosuvastatin decreased LDL cholesterol and apoB-100 levels in TRL, lbLDL, and sdLDL by significantly increasing the fractional catabolic rate of apoB-100 (TRL, +45%; lbLDL, +131%; and sdLDL, +97%), without a change in production...
July 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28391908/apob-lipoproteins-and-dysfunctional-white-adipose-tissue-relation-to-risk-factors-for-type-2-diabetes-in-humans
#12
Valérie Lamantia, Simon Bissonnette, Hanny Wassef, Yannick Cyr, Alexis Baass, Robert Dufour, Rémi Rabasa-Lhoret, May Faraj
BACKGROUND: Elevated plasma apoB is an independent predictor of T2D; however, underlying mechanisms remain unclear. Chronic reduction in white adipose tissue (WAT) function promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL induce their dysfunction (decreased hydrolysis and storage of triglyceride-rich lipoproteins [TRL]). OBJECTIVE: To examine the hypothesis that the association of plasma apoB with T2D risk factors, hypertriglyceridemia (hyperTG), insulin resistance (IR), and hyperinsulinemia, was dependent on WAT dysfunction...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28368338/electronic-noses-for-composites-surface-contamination-detection-in-aerospace-industry
#13
Saverio De Vito, Maria Lucia Miglietta, Ettore Massera, Grazia Fattoruso, Fabrizio Formisano, Tiziana Polichetti, Maria Salvato, Brigida Alfano, Elena Esposito, Girolamo Di Francia
The full exploitation of Composite Fiber Reinforced Polymers (CFRP) in so-called green aircrafts design is still limited by the lack of adequate quality assurance procedures for checking the adhesive bonding assembly, especially in load-critical primary structures. In this respect, contamination of the CFRP panel surface is of significant concern since it may severely affect the bonding and the mechanical properties of the joint. During the last years, the authors have developed and tested an electronic nose as a non-destructive tool for pre-bonding surface inspection for contaminants detection, identification and quantification...
April 2, 2017: Sensors
https://www.readbyqxmd.com/read/28365681/bone-marrow-derived-mononuclear-cell-therapy-accelerates-renal-ischemia-reperfusion-injury-recovery-by-modulating-inflammatory-antioxidant-and-apoptotic-related-molecules
#14
Felipe Mateus Ornellas, Débora Santos Ornellas, Sabrina Vargas Martini, Raquel Carvalho Castiglione, Grasiella Maria Ventura, Patrícia R Rocco, Bianca Gutfilen, Sergio A de Souza, Christina Maeda Takiya, Marcelo Marcos Morales
BACKGROUND/AIMS: We investigated the regenerative capacity of intravenous administration of bone marrow-derived mononuclear cells (BMMCs) in a rat model of bilateral renal ischemia/reperfusion (IR) injury and the involvement of inflammatory anti-inflammatory and other biological markers in this process. METHODS: Rats were subjected to 1h bilateral renal pedicle clamping. BMMCs were injected i.v 1h after reperfusion and tracked by 99mTc and GFP+ BMMCs. Twenty-four hours after reperfusion, renal function and histological changes were evaluated...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28356429/enrichment-of-triglyceride-rich-lipoproteins-with-apolipoprotein-c-i-is-positively-associated-with-their-delayed-plasma-clearance-independently-of-other-transferable-apolipoproteins-in-postmenopausal-overweight-and-obese-women
#15
Hanny Wassef, Simon Bissonnette, Robert Dufour, Jean Davignon, May Faraj
Background: The role of plasma apolipoprotein (apo) C-I in cardiometabolic risk in humans is unclear. However, in vitro studies showed a dual role for apoC-I, both protective and harmful, depending on the carrier lipoprotein.Objective: We tested the hypothesis that triglyceride (TG)-rich lipoprotein (TRL) apoC-I, not total or HDL apoC-I, is associated with delayed postprandial plasma clearance of TRLs, independently of apoC-II, apoC-III, and apoE.Methods: This cross-sectional study examines the plasma clearance of a (13)C-triolein-labeled high-fat meal (68% fat energy) in 20 postmenopausal overweight and obese women [body mass index (in kg/m(2)) ≥27; aged 45-74 y] as the increment change in area under the 6-h postprandial curves (iAUC6h) of TRL parameters...
May 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28327288/atrophin-controls-developmental-signaling-pathways-via-interactions-with-trithorax-like
#16
Kelvin Yeung, Ann Boija, Edvin Karlsson, Per-Henrik Holmqvist, Yonit Tsatskis, Ilaria Nisoli, Damian Yap, Alireza Lorzadeh, Michelle Moksa, Martin Hirst, Samuel Aparicio, Manolis Fanto, Per Stenberg, Mattias Mannervik, Helen McNeill
Mutations in human Atrophin1, a transcriptional corepressor, cause dentatorubral-pallidoluysian atrophy, a neurodegenerative disease. Drosophila Atrophin (Atro) mutants display many phenotypes, including neurodegeneration, segmentation, patterning and planar polarity defects. Despite Atro's critical role in development and disease, relatively little is known about Atro's binding partners and downstream targets. We present the first genomic analysis of Atro using ChIP-seq against endogenous Atro. ChIP-seq identified 1300 potential direct targets of Atro including engrailed, and components of the Dpp and Notch signaling pathways...
March 22, 2017: ELife
https://www.readbyqxmd.com/read/28315714/cadmium-induced-malignant-transformation-of-rat-liver-cells-potential-key-role-and-regulatory-mechanism-of-altered-apolipoprotein-e-expression-in-enhanced-invasiveness
#17
Masayo Suzuki, Shuso Takeda, Noriko Teraoka-Nishitani, Akane Yamagata, Takahiro Tanaka, Marika Sasaki, Natsuki Yasuda, Makiko Oda, Tatsuji Okano, Kazuhiro Yamahira, Yuta Nakamura, Takanobu Kobayashi, Katsuhito Kino, Hiroshi Miyazawa, Michael P Waalkes, Masufumi Takiguchi
Cadmium is a transition metal that is classified as human carcinogen by the International Agency for Research on Cancer (IARC) with multiple target sites. Many studies using various model systems provide evidence of cadmium-induced malignancy formation in vivo or malignant cell transformation in vitro. Nonetheless, further studies are needed to completely understand the mechanisms of cadmium carcinogenicity. Our prior studies have utilized a rat liver epithelial cell line (TRL 1215) as a model for cadmium-induced malignant transformation...
May 1, 2017: Toxicology
https://www.readbyqxmd.com/read/28302272/relation-of-fasting-triglyceride-rich-lipoprotein-cholesterol-to-coronary-artery-calcium-score-from-the-elsa-brasil-study
#18
Marcio S Bittencourt, Raul D Santos, Henrique Staniak, Rodolfo Sharovsky, Rao Kondapally, Antonio J Vallejo-Vaz, Kausik K Ray, Isabela Bensenor, Paulo Lotufo
Although low-density lipoprotein cholesterol (LDL-C) is widely accepted as the principal lipid fraction associated with atherosclerosis, emerging evidence suggests a causal relation between lifelong elevations in triglyceride-rich lipoprotein cholesterol (TRL-C) and cardiovascular disease (CVD) in genetic studies. To provide further evidence for the potential relevance of TRL-C and atherosclerosis, we have evaluated the relation between TRL-C and coronary artery calcium (CAC) score. We included 3,845 subjects (49...
May 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28276521/a-randomized-trial-and-novel-spr-technique-identifies-altered-lipoprotein-ldl-receptor-binding-as-a-mechanism-underlying-elevated-ldl-cholesterol-in-apoe4s
#19
M V Calabuig-Navarro, K G Jackson, C F Kemp, D S Leake, C M Walden, J A Lovegrove, A M Minihane
At a population level APOE4 carriers (~25% Caucasians) are at higher risk of cardiovascular diseases. The penetrance of genotype is however variable and influenced by dietary fat composition, with the APOE4 allele associated with greater LDL-cholesterol elevation in response to saturated fatty acids (SFA). The etiology of this greater responsiveness is unknown. Here a novel surface plasmon resonance technique (SPR) is developed and used, along with hepatocyte (with the liver being the main organ modulating lipoprotein metabolism and plasma lipid levels) uptake studies to establish the impact of dietary fatty acid composition on, lipoprotein-LDL receptor (LDLR) binding, and hepatocyte uptake, according to APOE genotype status...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218439/the-effects-of-exogenous-fatty-acids-and-niacin-on-human-monocyte-macrophage-plasticity
#20
Sergio Montserrat-de la Paz, Dolores Rodriguez, Magdalena P Cardelo, Maria C Naranjo, Beatriz Bermudez, Rocio Abia, Francisco J G Muriana, Sergio Lopez
SCOPE: Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages. METHODS AND RESULTS: We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
August 2017: Molecular Nutrition & Food Research
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