Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Marie-Claude Battista, Deborah J Cook, Gordon H Guyatt, Daren K Heyland, Salmaan Kanji, Ruxandra Pinto, Andrew G Day, Dian Cohen, Djillali Annane, Shay McGuinness, Rachael Parke, Anitra Carr, Yaseen Arabi, Bharath Kumar Tirupakuzhi Vijayaraghavan, Frédérick D'Aragon, Élaine Carbonneau, David Maslove, Miranda Hunt, Bram Rochwerg, Tina Millen, Michaël Chassé, Martine Lebrasseur, Patrick Archambault, Estel Deblois, Christine Drouin, François Lellouche, Patricia Lizotte, Irene Watpool, Rebecca Porteous, France Clarke, Nicole Marinoff, Émilie Belley-Côté, Brigitte Bolduc, Scott Walker, John Iazzetta, Neill K J Adhikari, François Lamontagne
BACKGROUND: Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis. METHODS: LOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800)...
January 8, 2020: Trials