Marie-Hélène Masse, Marie-Claude Battista, Mary Elizabeth Wilcox, Ruxandra Pinto, Nicole Marinoff, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Marc-André Leclair, Hector Quiroz Martinez, Brian Grondin-Beaudoin, Yannick Poulin, Élaine Carbonneau, Andrew J E Seely, Irene Watpool, Rebecca Porteous, Michaël Chassé, Martine Lebrasseur, François Lauzier, Alexis F Turgeon, David Bellemare, Sangeeta Mehta, Emmanuel Charbonney, Émilie Belley-Côté, Édouard Botton, Dian Cohen, François Lamontagne, Neill K J Adhikari
INTRODUCTION: Vasodilatory hypotension is common among intensive care unit (ICU) patients; vasopressors are considered standard of care. However, optimal mean arterial pressure (MAP) targets for vasopressor titration are unknown. The objective of the Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65) trial is to ascertain the effect of permissive hypotension (vasopressor titration to achieve MAP 60-65 mm Hg) versus usual care on biomarkers of organ injury in hypotensive patients aged ≥65 years...
November 14, 2020: BMJ Open