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https://www.readbyqxmd.com/read/29792731/apr3-modulates-oxidative-stress-and-mitochondrial-function-in-arpe-19-cells
#1
Yuan Li, Xuan Zou, Jing Gao, Ke Cao, Zhihui Feng, Jiankang Liu
Impairment of retinal pigment epithelial (RPE) cells is considered a key contributor to the development of age-related macular degeneration. Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells. However, the function of APR3 remains poorly understood. In the present study, we found that APR3 could interact with nuclear factor (erythroid-derived 2)-like 2, which is a regulator of phase II enzymes, and that knockdown of APR3 promoted nuclear factor (erythroid-derived 2)-like 2 nuclear translocation and activated expression of phase II enzymes, which was accompanied by improved redox status and mitochondrial activity...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29789262/eccentric-cycling-emphasising-a-low-cardiopulmonary-demand-increases-leg-strength-equivalent-to-workload-matched-concentric-cycling-in-middle-age-sedentary-males
#2
Michael C Lewis, Gregory E Peoples, Herbert Groeller, Marc A Brown
OBJECTIVES: This study determined if eccentric endurance cycling, eliciting a low cardiovascular demand, could stimulate muscle strength adaptations in sedentary middle-aged males. DESIGN: Twenty-four middle-aged sedentary males were allocated to concentric (CON) or matched workload eccentric (ECC) cycling (60% peak concentric workload) according to their maximal voluntary isometric quadriceps strength. METHODS: Seventeen participants [42...
May 15, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29787793/chlorogenic-acid-ameliorates-alcohol-induced-liver-injuries-through-scavenging-reactive-oxygen-species
#3
Hyunjin Kim, Jeong Hoon Pan, Sung Hwan Kim, Jin Hyup Lee, Jeen-Woo Park
The key role of oxidative stress in alcoholic liver disease (ALD) has been established by the large body of evidence from previous studies. Excessive consumption of ethanol induces the production of a variety of reactive oxygen species (ROS) in the liver, such as superoxide, H2 O2 , and hydroxyl radical. These products activate oxidant-sensitive signaling cascades and modulators of apoptosis. Because ROS accumulation is closely related to ALD, a number of studies have investigated the benefits of antioxidants...
May 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29787743/persistence-of-central-venous-oxygen-desaturation-during-early-sepsis-is-associated-with-higher-mortality-a-retrospective-analysis-of-the-albios-trial
#4
Alessandro Protti, Serge Masson, Roberto Latini, Roberto Fumagalli, Marilena Romero, Carla Pessina, Giovanni Pasetti, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Pietro Caironi
BACKGROUND: Relevance of low (<70%) central venous oxygen saturation (ScvO2 ) during early sepsis has been recently questioned by three negative trials (ProCESS, ARISE and ProMISe) on early goal-directed therapy (EGDT). However, subjects included in those trials had ScvO2 at enrolment as high as 71±13%, 73±11% and 70±12%. Herein we assessed the association between ScvO2 <70% at six hours and 90-day mortality in subjects enrolled in the ALBIOS trial, focusing on those with initial ScvO2 <70%...
May 19, 2018: Chest
https://www.readbyqxmd.com/read/29787609/an-investigation-of-cerebral-oxygen-utilization-blood-flow-and-cognition-in-healthy-aging
#5
Sarah J Catchlove, Helen Macpherson, Matthew E Hughes, Yufen Chen, Todd B Parrish, Andrew Pipingas
BACKGROUND: Understanding how vascular and metabolic factors impact on cognitive function is essential to develop efficient therapies to prevent and treat cognitive losses in older age. Cerebral metabolic rate of oxygen (CMRO2), cerebral blood flow (CBF) and venous oxygenation (Yv) comprise key physiologic processes that maintain optimum functioning of neural activity. Changes to these parameters across the lifespan may precede neurodegeneration and contribute to age-related cognitive decline...
2018: PloS One
https://www.readbyqxmd.com/read/29785255/feasibility-of-high-intensity-training-in-asthma
#6
L L Toennesen, E D Soerensen, M Hostrup, C Porsbjerg, J Bangsbo, V Backer
Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2 max)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29784452/regulation-of-the-oxidative-balance-with-coenzyme-q10-sensitizes-human-glioblastoma-cells-to-radiation-and-temozolomide
#7
Javier Frontiñán-Rubio, Raquel María Santiago-Mora, Consuelo María Nieva-Velasco, Gustavo Ferrín, Alicia Martínez-González, María Victoria Gómez, María Moreno, Julia Ariza, Eva Lozano, Jacinto Arjona-Gutiérrez, Antonio Gil-Agudo, Manuel De la Mata, Milica Pesic, Juan Ramón Peinado, José M Villalba, Luis Pérez-Romasanta, Víctor M Pérez-García, Francisco J Alcaín, Mario Durán-Prado
OBJECTIVES: To investigate how the modulation of the oxidative balance affects cytotoxic therapies in glioblastoma, in vitro. MATERIAL AND METHODS: Human glioblastoma U251 and T98 cells and normal astrocytes C8D1A were loaded with coenzyme Q10 (CoQ). Mitochondrial superoxide ion (O2 - ) and H2 O2 were measured by fluorescence microscopy. OXPHOS performance was assessed in U251 cells with an oxytherm Clark-type electrode. Radio- and chemotherapy cytotoxicity was assessed by immunostaining of γH2AX (24 h), annexin V and nuclei morphology, at short (72 h) and long (15 d) time...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29783783/the-microencapsulation-of-maqui-aristotelia-chilensis-mol-stuntz-juice-by-spray-drying-and-freeze-drying-produces-powders-with-similar-anthocyanin-stability-and-bioaccessibility
#8
Carolina Fredes, Camila Becerra, Javier Parada, Paz Robert
The microencapsulation of maqui juice by spray-drying and freeze-drying was studied as a strategy to protect anthocyanins in new food formulations in order to improve the anthocyanin retention before consumption and the bioaccessibility. It is well known that the encapsulation method affects both the shape and size of powders, being assumed that undefined forms of freeze-drying powders might affect their stability due to the high permeability to oxygen. The objective of this study was to compare the microencapsulation of maqui juice by spray-drying and freeze-drying, evaluating the stability of specific anthocyanins in yogurt and after in vitro digestion...
May 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29783116/modelling-environment-contamination-with-heavy-metals-in-flathead-grey-mullet-mugil-cephalus-and-upper-sediments-from-north-african-coasts-of-the-mediterranean-sea
#9
Naouel Ouali, Bourhane-Eddine Belabed, Haroun Chenchouni
Heavy metals are a serious hazard for aquatic ecosystems and human health. They negatively affect aquatic life functioning through accumulation resulting physiological/growth disturbances in aquatic lifeforms. This survey focused on the assessment of heavy metal pollution in the Gulf of Annaba (northeastern Algeria), the largest and most diversified industrial hub in Africa, using a multi-compartment approach (water-sediment-biota). The study aims to characterize the spatiotemporal variation of trace metal (TM) contamination and its effects on the growth of the Flathead grey mullet (Mugil cephalus)...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29781952/optimizing-temperature-and-oxygen-supports-long-term-culture-of-human-islets
#10
Hirotake Komatsu, Jeffrey Rawson, Leonard Medrano, Colin A Cook, Alyssa Barriga, Nelson Gonzalez, Mayra Salgado, Keiko Omori, Fouad Kandeel, Yu-Chong Tai, Yoko Mullen
BACKGROUND: Islet transplantation is a promising treatment for type-1 diabetes; however, donor shortage is a concern. Even when a pancreas is available, low islet yield limits the success of transplantation. Islet culture enables pooling of multiple low-yield isolations into an effective islet mass, but isolated islets rapidly deteriorate under conventional culture conditions. Oxygen depletion in the islet core, which leads to central necrosis and volume loss, is one of the major reasons for this deterioration...
May 16, 2018: Transplantation
https://www.readbyqxmd.com/read/29781941/cardiopulmonary-demand-of-16-kg-kettlebell-snatches-in-simulated-girevoy-sport
#11
Margaux Chan, Martin J MacInnis, Sarah Koch, Kristin E MacLeod, Keith R Lohse, Maria E Gallo, A William Sheel, Michael S Koehle
Chan, M, MacInnis, MJ, Koch, S, MacLeod, KE, Lohse, KR, Gallo, ME, Sheel, AW, and Koehle, MS. Cardiopulmonary demand of 16-kg kettlebell snatches in simulated Girevoy Sport. J Strength Cond Res XX(X): 000-000, 2018-Kettlebell lifting has become popular both as a strength and conditioning training tool and as a sport in and of itself: Girevoy Sport (GS). Although several kettlebell multimovement protocols have been analyzed, little research has attempted to quantify the aerobic stimulus of the individual events in GS, which could better inform kettlebell-related exercise prescription...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781608/characterization-of-the-il-electrode-interfacial-relaxation-processes-under-potential-polarization-for-ionic-liquid-amperometric-gas-sensor-method-development
#12
Lu Lin, Peng Zhao, Andrew J Mason, Xiangqun Zeng
Electrochemical amperometric sensors require a constant or varying potential at the working electrode that drives redox reactions of the analyte for detection. The interfacial redox reaction(s) can result in the formation of new chemical products that could change the initial condition of the electrode/electrolyte interface. If the products are not inert and/or cannot be removed from the system or if the initial condition of the electrode/electrolyte interface cannot be restored, the sensor signal baseline would consequently drift which is problematic for the continuous and real-time sensors...
May 21, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29781276/light-induced-hypoxia-triggered-living-nanocarriers-for-synergistic-cancer-therapy
#13
Wenliang Wang, Lin Lin, Xiaojing Ma, Bo Wang, Sanrong Liu, Xinxin Yan, Shengran Li, Huayu Tian, Xifei Yu
Living drug delivery system has been proposed as new concept materials since it is able to communicate with biological system, sense subtle changes of body microenvironment caused by disease and then make rapid response to cure in early stage of disease. Herein, taking full advantage of the tumor hypoxia physiology and successive effects of photodynamic therapy (PDT), we designed a new living delivery system via combining the PDT and hypoxia-responsive chemotherapy, abbreviated as Ce6-PEG-Azo-PCL. Then, according to the facts that oxygen can be converted into reactive oxygen species during irradiation of the photosensitizer, tumor cells could be killed after the poly(ethylene glycol) (PEG) conjugated photosensitizer chlorine e6 were irradiated at tumor site...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781122/protective-effects-of-endothelial-progenitor-cell-derived-extracellular-mitochondria-in-brain-endothelium
#14
Kazuhide Hayakawa, Su Jing Chan, Emiri T Mandeville, Ji Hyun Park, Morgan Bruzzese, Joan Montaner, Ken Arai, Anna Rosell, Eng H Lo
Endothelial progenitor cells (EPCs) have been pursued as a potential cellular therapy for stroke and central nervous system injury. However, their underlying mechanisms remain to be fully defined. Recent experimental studies suggest that mitochondria may be released and transferred between cells. In this proof-of-concept study, we asked whether beneficial effects of EPCs may partly involve a mitochondrial phenomenon as well. First, EPC-derived conditioned medium was collected and divided into supernatant and particle fractions after centrifugation...
May 21, 2018: Stem Cells
https://www.readbyqxmd.com/read/29778165/simultaneous-pyridine-biodegradation-and-nitrogen-removal-in-an-aerobic-granular-system
#15
Xiaodong Liu, Shijing Wu, Dejin Zhang, Jinyou Shen, Weiqing Han, Xiuyun Sun, Jiansheng Li, Lianjun Wang
Simultaneous pyridine biodegradation and nitrogen removal were successfully achieved in a sequencing batch reactor (SBR) based on aerobic granules. In a typical SBR cycle, nitritation occurred obviously after the majority of pyridine was removed, while denitrification occurred at early stage of the cycle when oxygen consumption was aggravated. The effect of several key operation parameters, i.e., air flow rate, influent NH4 + -N concentration, influent pH and pyridine concentration, on nitritation, pyridine degradation and total nitrogen (TN) removal, was systematically investigated...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777430/the-artificial-humic-substance-hs1500-does-not-inhibit-photosynthesis-of-the-green-alga-desmodesmus-armatus-in-vivo-but-interacts-with-the-photosynthetic-apparatus-of-isolated-spinach-thylakoids-in-vitro
#16
Matthias Gilbert, Hanno Bährs, Christian E W Steinberg, Christian Wilhelm
Humic substances (HSs) can influence the growth and composition of freshwater phytoplankton assemblage. Since HSs contain many phenolic and quinonic moieties and cause growth reductions in eco-physiological field experiments, HSs are considered photosystem II herbicides. To test this specific mode of action in vivo and in vitro, respectively, we used intact cells of the green alga Desmodesmus armatus, as well as thylakoids isolated from spinach (Spinacia oleracea) as a model system for the green algal chloroplast...
May 18, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29777261/mitochondrial-quality-control-in-amd-does-mitophagy-play-a-pivotal-role
#17
REVIEW
Juha M T Hyttinen, Johanna Viiri, Kai Kaarniranta, Janusz Błasiak
Age-related macular degeneration (AMD) is the predominant cause of visual loss in old people in the developed world, whose incidence is increasing. This disease is caused by the decrease in macular function, due to the degeneration of retinal pigment epithelium (RPE) cells. The aged retina is characterised by increased levels of reactive oxygen species (ROS), impaired autophagy, and DNA damage that are linked to AMD pathogenesis. Mitophagy, a mitochondria-specific type of autophagy, is an essential part of mitochondrial quality control, the collective mechanism responsible for this organelle's homeostasis...
May 18, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29776810/congenital-heart-disease-in-adults-assessmentof-functional-capacity-using-cardiopulmonary-exercise-testing
#18
Sílvia Aguiar Rosa, Ana Agapito, Rui M Soares, Lídia Sousa, José Alberto Oliveira, Ana Abreu, Ana Sofia Silva, Sandra Alves, Helena Aidos, Fátima F Pinto, Rui Cruz Ferreira
AIM: The aim of the study was to compare functional capacity in different types of congenital heart disease (CHD), as assessed by cardiopulmonary exercise testing (CPET). METHODS: A retrospective analysis was performed of adult patients with CHD who had undergone CPET in a single tertiary center. Diagnoses were divided into repaired tetralogy of Fallot, transposition of the great arteries (TGA) after Senning or Mustard procedures or congenitally corrected TGA, complex defects, shunts, left heart valve disease and right ventricular outflow tract obstruction...
May 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29775797/functional-screening-of-selective-mitochondrial-inhibitors-of-plasmodium
#19
Maria G Gomez-Lorenzo, Ane Rodríguez-Alejandre, Sonia Moliner-Cubel, María Martínez-Hoyos, Noemí Bahamontes-Rosa, Rubén Gonzalez Del Rio, Carolina Ródenas, Jesús de la Fuente, Jose Luis Lavandera, Jose F García-Bustos, Alfonso Mendoza-Losana
Phenotypic screening has produced most of the new chemical entities currently in clinical development for malaria, plus many lead compounds active against Plasmodium falciparum asexual stages. However, lack of knowledge about the mode of action of these compounds delays and may even hamper their future development. Identifying the mode of action of the inhibitors greatly helps to prioritise compounds for further development as novel antimalarials. Here we describe a whole-cell method to detect inhibitors of the mitochondrial electron transport chain, using oxygen consumption as high throughput readout in 384-well plate format...
May 9, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29774606/nitrogen-doped-cop-electrocatalysts-for-coupled-hydrogen-evolution-and-sulfur-generation-with-low-energy-consumption
#20
Qingwen Zhou, Zihan Shen, Chao Zhu, Jiachen Li, Zhiyuan Ding, Peng Wang, Feng Pan, Zhiyong Zhang, Haixia Ma, Shuangyin Wang, Huigang Zhang
Hydrogen production is the key step for the future hydrogen economy. As a promising H2 production route, electrolysis of water suffers from high overpotentials and high energy consumption. This study proposes an N-doped CoP as the novel and effective electrocatalyst for hydrogen evolution reaction (HER) and constructs a coupled system for simultaneous hydrogen and sulfur production. Nitrogen doping lowers the d-band of CoP and weakens the H adsorption on the surface of CoP because of the strong electronegativity of nitrogen as compared to phosphorus...
May 17, 2018: Advanced Materials
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