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https://www.readbyqxmd.com/read/29348645/a-global-perspective-on-the-trophic-geography-of-sharks
#1
Christopher S Bird, Ana Veríssimo, Sarah Magozzi, Kátya G Abrantes, Alex Aguilar, Hassan Al-Reasi, Adam Barnett, Dana M Bethea, Gérard Biais, Asuncion Borrell, Marc Bouchoucha, Mariah Boyle, Edward J Brooks, Juerg Brunnschweiler, Paco Bustamante, Aaron Carlisle, Diana Catarino, Stéphane Caut, Yves Cherel, Tiphaine Chouvelon, Diana Churchill, Javier Ciancio, Julien Claes, Ana Colaço, Dean L Courtney, Pierre Cresson, Ryan Daly, Leigh de Necker, Tetsuya Endo, Ivone Figueiredo, Ashley J Frisch, Joan Holst Hansen, Michael Heithaus, Nigel E Hussey, Johannes Iitembu, Francis Juanes, Michael J Kinney, Jeremy J Kiszka, Sebastian A Klarian, Dorothée Kopp, Robert Leaf, Yunkai Li, Anne Lorrain, Daniel J Madigan, Aleksandra Maljković, Luis Malpica-Cruz, Philip Matich, Mark G Meekan, Frédéric Ménard, Gui M Menezes, Samantha E M Munroe, Michael C Newman, Yannis P Papastamatiou, Heidi Pethybridge, Jeffrey D Plumlee, Carlos Polo-Silva, Katie Quaeck-Davies, Vincent Raoult, Jonathan Reum, Yassir Eden Torres-Rojas, David S Shiffman, Oliver N Shipley, Conrad W Speed, Michelle D Staudinger, Amy K Teffer, Alexander Tilley, Maria Valls, Jeremy J Vaudo, Tak-Cheung Wai, R J David Wells, Alex S J Wyatt, Andrew Yool, Clive N Trueman
Sharks are a diverse group of mobile predators that forage across varied spatial scales and have the potential to influence food web dynamics. The ecological consequences of recent declines in shark biomass may extend across broader geographic ranges if shark taxa display common behavioural traits. By tracking the original site of photosynthetic fixation of carbon atoms that were ultimately assimilated into muscle tissues of 5,394 sharks from 114 species, we identify globally consistent biogeographic traits in trophic interactions between sharks found in different habitats...
January 18, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29348559/plk1-protects-against-sepsis-induced-intestinal-barrier-dysfunction
#2
Yingya Cao, Qun Chen, Zhen Wang, Tao Yu, Jingyi Wu, Xiaogan Jiang, Xiaoju Jin, Weihua Lu
Sepsis and sepsis-associated intestinal barrier dysfunction are common in intensive care units, with high mortality. The aim of this study is to investigate whether Polo-like kinase 1 (PLK1) ameliorates sepsis-induced intestinal barrier dysfunction in the intestinal epithelium. The mouse intestinal barrier was disrupted after Lipopolysaccharide (LPS) injection due to intestinal epithelial cell apoptosis and proliferation inhibition, accompanied by decreased PLK1. In HT-29 intestinal epithelial cells, LPS stimulation induced cell apoptosis and inhibited cell proliferation...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343133/central-nervous-system-malformation-associated-with-methamphetamine-abuse-during-pregnancy
#3
Silvia Maya-Enero, Júlia Candel-Pau, Mónica Rebollo-Polo, Santiago Candela-Cantó, Rafael de la Torre, María Ángeles López-Vílchez
INTRODUCTION: Prenatal methamphetamine exposure is related to prematurity, fetal growth restriction, neurobehavioral effects and long-term motor and cognitive sequelae. PATIENT PRESENTATION: We report the case of a newborn from a Filipina with no prenatal care with a complex brain malformation. Methamphetamine was identified in maternal and neonatal urine and in maternal hair, raising our suspicion of methamphetamine as a cause of this malformation. DISCUSSION: Methamphetamine abuse is a growing problem worldwide...
January 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29340480/bone-repair-access-of-boneceramic%C3%A2-in-5-mm-defects-study-on-rat-calvaria
#4
André Luis da Silva Fabris, Leonardo Perez Faverani, Pedro Henrique Silva Gomes-Ferreira, Tárik Ocon Braga Polo, Joel Ferreira Santiago-Júnior, Roberta Okamoto
OBJECTIVE: The aim of this study was to evaluate the osteoconductive potential of BoneCeramic™ on bone healing in rat calvaria 5-mm defects. MATERIAL AND METHODS: A 5-mm calvaria bone defect was induced in three groups and the defect was not filled with biomaterial [Clot Group (CG)], autogenous bone (AG), or Bone Ceramic Group (BCG). Animals were euthanized after 14 or 28 days and the bone tissue within the central area of the bone defect was evaluated. Results were compared using ANOVA and Tukey test (p<0...
January 15, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29340047/inhibition-of-polo-like-kinase-4-plk4-a-new-therapeutic-option-for-rhabdoid-tumors-and-pediatric-medulloblastoma
#5
Simone Treiger Sredni, Anders W Bailey, Amreena Suri, Rintaro Hashizume, Xingyao He, Nundia Louis, Tufan Gokirmak, David R Piper, Daniel M Watterson, Tadanori Tomita
Rhabdoid tumors (RT) are highly aggressive and vastly unresponsive embryonal tumors. They are the most common malignant CNS tumors in infants below 6 months of age. Medulloblastomas (MB) are embryonal tumors that arise in the cerebellum and are the most frequent pediatric malignant brain tumors. Despite the advances in recent years, especially for the most favorable molecular subtypes of MB, the prognosis of patients with embryonal tumors remains modest with treatment related toxicity dreadfully high. Therefore, new targeted therapies are needed...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339720/plumbagin-inhibits-the-proliferation-and-survival-of-esophageal-cancer-cells-by-blocking-stat3-plk1-akt-signaling
#6
Ying-Ya Cao, Jing Yu, Ting-Ting Liu, Kai-Xia Yang, Li-Yan Yang, Qun Chen, Feng Shi, Jia-Jie Hao, Yan Cai, Ming-Rong Wang, Wei-Hua Lu, Yu Zhang
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent manner in vitro. The drug also effectively inhibited the viability of primary ESCC cells from fresh biopsy specimens. Furthermore, plumbagin-induced mitotic arrest and massive apoptosis in ESCC cells...
January 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29339188/the-enhancement-of-siplk1-penetration-across-bbb-and-its-anti-glioblastoma-activity-in-vivo-by-magnet-and-transferrin-co-modified-nanoparticle
#7
Dao-Zhou Liu, Ying Cheng, Rong-Qiao Cai, Wen-Wen Wang, Han Cui, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou
In order to enhance the penetration of small interference RNA against the polo-like kinase I (siPLK1) across BBB to treat glioblastoma (GBM), transferrin (Tf) modified magnetic nanoparticle (Tf-PEG-PLL/MNP@siPLK1) was prepared. The in vitro experiments indicated that Tf-PEG-PLL/MNP@siPLK1 enhanced the cellular uptake of siPLK1, which resulted in an increase of gene silencing effect and cytotoxicity of Tf-PEG-PLL/MNP@siPLK1 on U87 cells. Besides, Tf-PEG-PLL/MNP@siPLK1 significantly inhibited the growth of U87 glioblastoma spheroids and markedly increased the BBB penetration efficiency of siPLK1 with the application of external magnetic field in in-vitro BBB model...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29338934/systematic-review-of-the-safety-and-effectiveness-of-peripheral-neurostimulation-of-the-sphenopalatine-ganglion-for-the-treatment-of-refractory-chronic-cluster-headache
#8
L M Sánchez-Gómez, M Polo-deSantos, A Pinel-González, C Oreja-Guevara, S Luengo-Matos
INTRODUCTION: This study aimed to assess the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion (SPG) in the treatment of refractory chronic cluster headache. DEVELOPMENT: Various medical databases were used to perform a systematic review of the scientific literature. The search for articles continued until 31 October 2016, and included clinical trials, systematic reviews and/or meta-analyses, health technology assessment reports, and clinical practice guidelines that included measurements of efficiency/effectiveness or adverse effects associated with the treatment...
January 12, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29336340/-training-program-on-medical-urology-future-perspectives
#9
Javier Gil Moradillo, Fernando Cabrera Meiras, Manuel Alonso Isa, Alba Lara Isla, Juan Justo Quintas, Esther García Rojo, Daniel González Padilla, Borja García Gómez, José Medina Polo, Javier Romero Otero
Urology is defined as the medical-surgical specialty that includes the study, diagnosis and treatment of medical conditions of the urinary system. It is well specified by the National Commission of Specialties that we must know the medical pathology that concerns us. However, on occasions, resident training focuses on the surgical field and oncological pathology, which, although one of the main pillars of the specialty, is usually to the detriment of training in medical and functional pathology. We conducted a survey of residents in the fourth year of Urology in Spain, where we asked about the quality of training in Andrology and Functional Urology...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29331044/journey-of-oocyte-from-metaphase-i-to-metaphase-ii-stage-in-mammals
#10
Alka Sharma, Meenakshi Tiwari, Anumegha Gupta, Ashutosh N Pandey, Pramod K Yadav, Shail K Chaube
In mammals, journey from metaphase-I (M-I) to metaphase-II (M-II) is important since oocyte extrude first polar body (PB-I) and gets converted into haploid gamete. The molecular and cellular changes associated with meiotic cell cycle progression from M-I to M-II stage and extrusion of PB-I remain ill understood. Several factors drive oocyte meiosis from M-I to M-II stage. The mitogen-activated protein kinase3/1 (MAPK3/1), signal molecules and Rho family GTPases act through various pathways to drive cell cycle progression from M-I to M-II stage...
January 13, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29330283/centriole-overduplication-is-the-predominant-mechanism-leading-to-centrosome-amplification-in-melanoma
#11
Ryan A Denu, Maria Shabbir, Minakshi Nihal, Chandra K Singh, B Jack Longley, Mark E Burkard, Nihal Ahmad
Centrosome amplification (CA) is common in cancer and can arise by centriole overduplication or by cell doubling events, including the failure of cell division and cell-cell fusion. To assess the relative contributions of these two mechanisms, the number of centrosomes with mature/mother centrioles was examined by immunofluorescence in a tissue microarray (TMA) of human melanomas and benign nevi (n=79 and 17, respectively). The centrosomal protein 170 (CEP170) was used to identify centrosomes with mature centrioles; this is expected to be present in most centrosomes with cell doubling, but on fewer centrosomes with overduplication...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29329658/novel-compounds-with-potent-cdk9-inhibitory-activity-for-the-treatment-of-myeloma
#12
Zsófia Czudor, Mária Balogh, Péter Bánhegyi, Sándor Boros, Nóra Breza, Judit Dobos, Márk Fábián, Zoltán Horváth, Eszter Illyés, Péter Markó, Anna Sipos, Csaba Szántai-Kis, Bálint Szokol, László Őrfi
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226)...
January 2, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29323557/neuropsychological-assessment-of-412-hiv-infected-individuals-in-s%C3%A3-o-paulo-brazil
#13
Maria Rita Polo Gascón, José Ernesto Vidal, Yolanda Marques Mazzaro, Jerusa Smid, Rosa Maria Nascimento Marcusso, Claudio Garcia Capitão, Elizeu Macedo Coutinho, Glaucia Rosana Guerra Benute, Mara Cristina Souza De Lucia, Augusto César Penalva de Oliveira
HIV-associated neurocognitive disorders (HAND) remain frequent even among individuals receiving combined antiretroviral therapy (cART). In addition, HAND may adversely affect the quality of life and adherence to cART. There is scarce epidemiological information about HAND in Latin America. This cross-sectional study recruited HIV-infected patients from a tertiary teaching institution in São Paulo, Brazil, between May 2013 and February 2015. The patients were adults with at least 4 years of education and patients with current neurological or psychiatric diseases were excluded...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29318485/removal-of-imidazolium-and-pyridinium-based-ionic-liquids-by-fenton-oxidation
#14
Esther Gomez-Herrero, Montserrat Tobajas, Alicia Polo, Juan J Rodriguez, Angel F Mohedano
The oxidation of imidazolium (1-hexyl-3-methylimidazolium chloride, HmimCl) and pyridinium (1-butyl-4-methylpyridinium chloride, BmpyrCl) ionic liquids (ILs) by Fenton's reagent has been studied. Complete conversion was achieved for both ILs using the stoichiometric H2O2 dose at 70 °C, reaching final TOC conversion values around 45 and 55% for HmimCl and BmpyrCl, respectively. The decrease in hydrogen peroxide dose to substoichiometric concentrations (20-80% stoichiometric dose) caused a decrease in TOC conversion and COD removal and the appearance of hydroxylated oxidation by-products...
January 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29317121/redefining-minimally-invasive-glaucoma-surgery-minimally-penetrating-glaucoma-surgery
#15
J García-Feijóo, J M Larrosa, J M Martínez-de-la-Casa, V Polo, L P Julvez
No abstract text is available yet for this article.
January 6, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29315962/multiple-dicer1-related-tumors-in-a-child-with-a-large-interstitial-14q32-deletion
#16
Leanne de Kock, Dominique Geoffrion, Barbara Rivera, Rabea Wagener, Nelly Sabbaghian, Susanne Bens, Benjamin Ellezam, Dorothée Bouron-Dal Soglio, Jessica Ordóñez, Stephanie Sacharow, Jose Fernando Polo Nieto, R Paul Guillerman, Gordan M Vujanic, John R Priest, Reiner Siebert, William D Foulkes
Germ-line interstitial deletions involving the 14q32 chromosomal region, resulting in 14q32 deletion syndrome, are rare. DICER1 is a recently described cancer-predisposition gene located at 14q32.13. We report the case of a male child with an approximately 5.8 Mbp 14q32.13q32.2 germ-line deletion, which included the full DICER1 locus. We reviewed available clinical and pathological material, and conducted genetic analyses. In addition to having congenital dysmorphic features, the child developed multiple DICER1 syndrome-related tumors before age 5 years: a pediatric cystic nephroma (pCN), a ciliary body medulloepithelioma (CBME), and a small lung cyst (consistent with occult pleuropulmonary blastoma Type I/Ir cysts seen in DICER1 mutation carriers)...
January 9, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29297767/-wealthy-gay-couples-buying-babies-produced-in-india-by-poor-womb-women-audience-interpretations-of-transnational-surrogacy-in-tv-news
#17
Rafael Ventura, Xosé Ramón Rodríguez-Polo, Carles Roca-Cuberes
Surrogacy is beginning to generate public debate and the way the media approach it may have negative effects on social attitudes towards gay parenting. The news media play a key role in informing society, especially about topics such as surrogacy, of which most audiences have no direct experience. The aim of our research is to explore opinion formation of surrogacy and gay parenting by analysing the audience interpretation of a TV news story in Spain. To do this we conducted four focus groups that were analyzed using a qualitative content analysis based on the discourse produced by the participants...
January 3, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29296234/the-pyrazolyl-urea-gege3-inhibits-tumor-angiogenesis-and-reveals-dystrophia-myotonica-protein-kinase-dmpk-1-as-a-novel-angiogenesis-target
#18
Elda Meta, Beat A Imhof, Patricia Ropraz, Richard J Fish, Chiara Brullo, Olga Bruno, Adama Sidibé
The limitation of targeting VEGF/VEGFR2 signalling to stop angiogenesis in cancer therapy has been blamed on re-activation of alternative receptor tyrosine kinases by compensatory angiogenic factors. Targeting MAPK and PI3K signaling pathways in endothelial cells may be an alternative or complementary approach. Herein we aimed to evaluate the antitumor and antiangiogenic potential of a novel pyrazolyl-urea kinase inhibitor, GeGe3, and to identify its kinase targets. We found GeGe3 to inhibit the proliferation of HUVEC and endothelial tube formation...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288948/design-synthesis-and-biological-evaluation-of-polo-like-kinase-1-eukaryotic-elongation-factor-2-kinase-plk1-eef2k-dual-inhibitors-for-regulating-breast-cancer-cells-apoptosis-and-autophagy
#19
Zhaoping Pan, Yujuan Chen, Jingyan Liu, Qinglin Jiang, Shengyong Yang, Li Guo, Gu He
Both PLK1 and EEF2K are serine⁄threonine kinases that play important roles in the proliferation and programmed cell death of various types of cancer. They are highly expressed in breast cancer tissues. Based on the multiple-complexes generated pharmacophore models of PLK1 and homology models of EEF2K, the integrated virtual screening is performed to discover novel PLK1/EEF2K dual inhibitors. The top ten hit compounds are selected and tested in vitro, and five of them display PLK1 and EEF2K inhibition in vitro...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29277255/validation-and-application-of-a-multiresidue-method-based-on-liquid-chromatography-tandem-mass-spectrometry-for-evaluating-the-plant-uptake-of-74-microcontaminants-in-crops-irrigated-with-treated-municipal-wastewater
#20
A B Martínez-Piernas, M I Polo-López, P Fernández-Ibáñez, A Agüera
Reuse of treated wastewater for agricultural purposes can mitigate water stress in some regions where the lack of water is an extended problem. However, the environmental long-term consequences of this practice are still unknown. It is demonstrated that using reclaimed water for irrigation lead to accumulation and translocation of some microcontaminants (MCs) in soil and crops. However, so far, only a small group of contaminants has been investigated. This study aims to develop and validate a simple and efficient multiresidue method based on QuEChERs (Quick, Easy, Cheap, Effective and Rugged) extraction coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS)...
December 15, 2017: Journal of Chromatography. A
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